endemic diseases

Summary

Summary: The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)

Top Publications

  1. pmc Clinical algorithms for malaria diagnosis lack utility among people of different age groups
    Tabitha W Mwangi
    Kenya Medical Research Institute, CGMRC Wellcome Trust Collaborative Program, Kilifi, Kenya
    Trop Med Int Health 10:530-6. 2005
  2. pmc A world malaria map: Plasmodium falciparum endemicity in 2007
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome TrustCollaborative Programme, Nairobi, Kenya
    PLoS Med 6:e1000048. 2009
  3. ncbi Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 200:1509-17. 2009
  4. pmc Estimating the global clinical burden of Plasmodium falciparum malaria in 2007
    Simon I Hay
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 7:e1000290. 2010
  5. ncbi Leishmaniasis and poverty
    Jorge Alvar
    Communicable Diseases, Neglected Tropical Diseases Control, World Health Organization, 20 Ave Appia, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 22:552-7. 2006
  6. pmc Continued decline of malaria in The Gambia with implications for elimination
    Serign J Ceesay
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS ONE 5:e12242. 2010
  7. ncbi Household risk factors for malaria among children in the Ethiopian highlands
    T A Ghebreyesus
    Tigray Health Bureau, Mekelle, Ethiopia
    Trans R Soc Trop Med Hyg 94:17-21. 2000
  8. pmc Ranking of elimination feasibility between malaria-endemic countries
    Andrew J Tatem
    Department of Geography, University of Florida, Gainesville, FL 32610, USA edu
    Lancet 376:1579-91. 2010
  9. pmc The global distribution and population at risk of malaria: past, present, and future
    Simon I Hay
    TALA Research Group, Department of Zoology, University of Oxford, Oxford, UK
    Lancet Infect Dis 4:327-36. 2004
  10. ncbi Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda
    Heidi Hopkins
    University of California, San Francisco, San Francisco, California, USA
    J Infect Dis 197:510-8. 2008

Detail Information

Publications265 found, 100 shown here

  1. pmc Clinical algorithms for malaria diagnosis lack utility among people of different age groups
    Tabitha W Mwangi
    Kenya Medical Research Institute, CGMRC Wellcome Trust Collaborative Program, Kilifi, Kenya
    Trop Med Int Health 10:530-6. 2005
    ....
  2. pmc A world malaria map: Plasmodium falciparum endemicity in 2007
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome TrustCollaborative Programme, Nairobi, Kenya
    PLoS Med 6:e1000048. 2009
    ..It is exactly 40 y since the last global map of malaria endemicity was published. This paper describes the generation of a new world map of Plasmodium falciparum malaria endemicity for the year 2007...
  3. ncbi Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 200:1509-17. 2009
    ..Quantifying these submicroscopic infections is therefore key to understanding transmission dynamics and successfully reducing parasite transmission...
  4. pmc Estimating the global clinical burden of Plasmodium falciparum malaria in 2007
    Simon I Hay
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 7:e1000290. 2010
    ....
  5. ncbi Leishmaniasis and poverty
    Jorge Alvar
    Communicable Diseases, Neglected Tropical Diseases Control, World Health Organization, 20 Ave Appia, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 22:552-7. 2006
    ..Public investment in treatment and control would decrease the leishmaniasis disease burden and help to alleviate poverty...
  6. pmc Continued decline of malaria in The Gambia with implications for elimination
    Serign J Ceesay
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS ONE 5:e12242. 2010
    ..Scale up of interventions has since increased with support from the Global Fund and other donors...
  7. ncbi Household risk factors for malaria among children in the Ethiopian highlands
    T A Ghebreyesus
    Tigray Health Bureau, Mekelle, Ethiopia
    Trans R Soc Trop Med Hyg 94:17-21. 2000
    ....
  8. pmc Ranking of elimination feasibility between malaria-endemic countries
    Andrew J Tatem
    Department of Geography, University of Florida, Gainesville, FL 32610, USA edu
    Lancet 376:1579-91. 2010
    ....
  9. pmc The global distribution and population at risk of malaria: past, present, and future
    Simon I Hay
    TALA Research Group, Department of Zoology, University of Oxford, Oxford, UK
    Lancet Infect Dis 4:327-36. 2004
    ....
  10. ncbi Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda
    Heidi Hopkins
    University of California, San Francisco, San Francisco, California, USA
    J Infect Dis 197:510-8. 2008
    ..In Africa, fever is often treated presumptively as malaria, resulting in misdiagnosis and the overuse of antimalarial drugs. Rapid diagnostic tests (RDTs) for malaria may allow improved fever management...
  11. pmc Measuring malaria endemicity from intense to interrupted transmission
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome Trust Collaborative Programme, Nairobi, Kenya
    Lancet Infect Dis 8:369-78. 2008
    ..These considerations are also important to an international community that has recently been challenged to revaluate the prospects for malaria eradication...
  12. pmc Equity and adequacy of international donor assistance for global malaria control: an analysis of populations at risk and external funding commitments
    Robert W Snow
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute, Nairobi, Kenya
    Lancet 376:1409-16. 2010
    ..We aimed to identify the unmet financial needs that would be biologically and economically equitable and would increase the chances of reaching worldwide malaria-control ambitions...
  13. pmc Schistosomiasis control in China: the impact of a 10-year World Bank Loan Project (1992-2001)
    Chen Xianyi
    Department of Diseases Control, Ministry of Health, Beijing, China
    Bull World Health Organ 83:43-8. 2005
    ..One province, Zhejiang, had already fulfilled the criteria for elimination of schistosomiasis by 1995. The project was therefore a success and has provided China with a sound basis for further control...
  14. ncbi Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
    ..To develop an evidenced-based reassessment of schistosomiasis-related disability, we did a systematic review of data on disability-associated outcomes for all forms of schistosomiasis...
  15. pmc Use of over-the-counter malaria medicines in children and adults in three districts in Kenya: implications for private medicine retailer interventions
    Timothy O Abuya
    Kenya Medical Research Institute Wellcome Trust Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Malar J 6:57. 2007
    ..Data on adult use of over-the-counter (OTC) medicines is limited. This study aimed to assess childhood and adult patterns of OTC medicine use to inform national medicine retailer programmes in Kenya and other similar settings...
  16. ncbi Impact of malaria control on childhood anaemia in Africa -- a quantitative review
    Eline L Korenromp
    World Health Organization, Roll Back Malaria, Geneva, Switzerland
    Trop Med Int Health 9:1050-65. 2004
    ..To review the impact of malaria control on haemoglobin (Hb) distributions and anaemia prevalences in children under 5 in malaria-endemic Africa...
  17. ncbi The epidemiology of visceral leishmaniasis and asymptomatic leishmanial infection in a highly endemic Bangladeshi village
    Caryn Bern
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 76:909-14. 2007
    ..The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease...
  18. ncbi A canine purgation study and risk factor analysis for echinococcosis in a high endemic region of the Tibetan plateau
    Christine M Budke
    Institute for Parasitology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Vet Parasitol 127:43-49. 2005
    ..Male dogs were more likely to be infected with Echinococcus spp. than female dogs (P<0.05) and dogs allowed to roam were more likely to be infected with E. multilocularis (P<0.05)...
  19. pmc Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine
    Jianping Song
    Research Centre for Qinghao, Guangzhou University of Chinese Medicine, Guangzhou, PR China
    Malar J 9:57. 2010
    ..Using an artemisinin-based combination therapy (ACT) that kills parasites quickly, a strategy was designed to eliminate the source of transmission by mass treatment of human populations in malaria-endemic areas Cambodia...
  20. pmc Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children
    Enmoore Lin
    PNG Institute of Medical Research, Madang, Papua New Guinea
    PLoS ONE 5:e9047. 2010
    ..vivax than to P. falciparum challenge. There is however little prospective data on the comparative risk of infection and disease from both species in young children living in co-endemic areas...
  21. ncbi Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar, India
    S P Singh
    Kala azar Medical Research Center, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Trop Med Int Health 11:899-905. 2006
    ..Survey results were compared with official reports of the disease to assess the extent of underreporting by the Government health system...
  22. pmc Spatial co-distribution of neglected tropical diseases in the east African great lakes region: revisiting the justification for integrated control
    Archie C A Clements
    School of Population Health, University of Queensland, Herston, QLD, Australia
    Trop Med Int Health 15:198-207. 2010
    ....
  23. ncbi Trachoma: global magnitude of a preventable cause of blindness
    S P Mariotti
    Chronic Disease and Health Promotion Department, Prevention of Blindness and Deafness, World Health Organization, Geneva, Switzerland
    Br J Ophthalmol 93:563-8. 2009
    ..6 million were severely visually impaired or blind as a result of trachoma: this study provides an updated estimate of the global prevalence of trachoma based on the most recent information available...
  24. pmc Coupling between annual and ENSO timescales in the malaria-climate association in Colombia
    G Poveda
    Postgrado en Aprovechamiento de Recursos Hidráulicos, Universidad Nacional de Colombia, Medellin, Colombia
    Environ Health Perspect 109:489-93. 2001
    ....
  25. ncbi Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial
    Jean Loup Lemesre
    Institut de Recherche pour le Developpement, UR 008 Pathogénie des Trypanosomatidae, Equipe 1, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Vaccine 25:4223-34. 2007
    ..The LiESAp-MDP vaccine induced a significant, long-lasting and strong protective effect against canine visceral leishmaniasis in the field...
  26. ncbi Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya
    A M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106 4983, USA
    Trans R Soc Trop Med Hyg 97:513-4. 2003
    ..Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands...
  27. pmc Prevalence of tick borne encephalitis virus in tick nymphs in relation to climatic factors on the southern coast of Norway
    Ashild Andreassen
    Division of Infectious Disease Control, Department of Virology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway
    Parasit Vectors 5:177. 2012
    ..The objectives of this study were to estimate the TBEV prevalence in Ixodes ricinus from seven locations and to assess the relationship between the TBEV prevalence and site-specific climatic variables...
  28. ncbi Laboratory tests performed on Leishmania seroreactive dogs euthanized by the leishmaniasis control program
    D A Silva
    Pós graduação Stricto sensu, Instituto de Pesquisa Clínica Evandro Chagas IPEC, Fundação Oswaldo Cruz FIOCRUZ, Brazil
    Vet Parasitol 179:257-61. 2011
    ..The findings indicate that the visceral leishmaniasis control program needs to be adjusted in order to avoid non-infected dogs from being removed or permit that dogs infected with L. chagasi to remain undetected in endemic areas...
  29. pmc Mapping hypoendemic, seasonal malaria in rural Bandarban, Bangladesh: a prospective surveillance
    Wasif A Khan
    ICDDR, B International Centre for Diarrhoeal Disease Research, Clinical Sciences Division
    Malar J 10:124. 2011
    ....
  30. pmc Population, behavioural and environmental drivers of malaria prevalence in the Democratic Republic of Congo
    Jane P Messina
    Department of Geography, University of North Carolina, Chapel Hill, NC, USA
    Malar J 10:161. 2011
    ..It is important to discern these patterns as well as the drivers which may underlie them in order for effective prevention measures to be carried out...
  31. ncbi Environmental sanitary interventions for preventing active trachoma
    Mansur Rabiu
    Prevention of Blindness Union, Riyadh, Saudi Arabia
    Cochrane Database Syst Rev 2:CD004003. 2012
    ..One of the major strategies advocated for the control of the disease is the application of various environmental sanitary measures to such communities...
  32. pmc Local transmission of imported endemic syphilis, Canada, 2011
    Sergio Fanella
    University of Manitoba, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 18:1002-4. 2012
    ..Improved molecular tools and global clinical awareness are needed to recognize cases of endemic syphilis imported to areas where it is not normally seen...
  33. ncbi Loiasis
    M Boussinesq
    Institut de recherche pour le developpement IRD, UR024, département Sociétés et Santé, 213 rue La Fayette, 75480 Paris cedex 10, France
    Ann Trop Med Parasitol 100:715-31. 2006
    ..New diagnostic tools have also been developed in the last decade, and various protocols are now available for the risk-free treatment of loiasis cases...
  34. pmc Effect of control strategies on prevalence, incidence and re-infection of clonorchiasis in endemic areas of China
    Min Ho Choi
    Department of Parasitology and Tropical Medicine and Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
    PLoS Negl Trop Dis 4:e601. 2010
    ..A pilot clonorchiasis control project was implemented to evaluate the efficacies of various chemotherapy strategies on prevalence, incidence and re-infection in Heilongjiang Province, China...
  35. ncbi The risk of chikungunya fever in a dengue-endemic area
    Eduardo Massad
    School of Medicine, University of Sao Paulo, LIM 01 HCFMUSP, Sao Paulo, Brazil
    J Travel Med 15:147-55. 2008
    ..In addition, traveling to these areas is popular, making the potential risk of infections transmitted by the bite of infected Aedes mosquitoes very high...
  36. ncbi Long-term asymptomatic carriage of Plasmodium falciparum protects from malaria attacks: a prospective study among Senegalese children
    Sylvia Males
    Institut de Recherche pour Développement, UR010, Dakar, Senegal
    Clin Infect Dis 46:516-22. 2008
    ....
  37. ncbi Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors
    Erik R Dubberke
    Washington University School of Medicine, St Louis, Missouri, USA
    Clin Infect Dis 45:1543-9. 2007
    ..The purpose of this study was to determine risk factors for endemic CDAD, including CDAD pressure, a modified version of colonization pressure...
  38. pmc Tickborne encephalitis in naturally exposed monkey (Macaca sylvanus)
    Jochen Süss
    Friedrich Loeffler Institute, Jena, Germany
    Emerg Infect Dis 13:905-7. 2007
    ..TBE virus was present in the brain and could be identified as closely related to the European subtype, strain Neudoerfl...
  39. ncbi The endemic treponematoses
    Georg Michael Antal
    Department of Medicine, University of Washington, Seattle, 98195, USA
    Microbes Infect 4:83-94. 2002
    ..The endemic treponematoses have not yet been eliminated and are currently thought to affect at least 2.5 million persons. Renewed action towards the elimination of these diseases should be undertaken...
  40. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  41. ncbi Immune interactions in malaria co-infections with other endemic infectious diseases: implications for the development of improved disease interventions
    Marita Troye-Blomberg
    Department of Immunology, Wenner Gren Institute, Stockholm University, Svante Arrheniusväg 16, SE 106 91 Stockholm, Sweden
    Microbes Infect 10:948-52. 2008
    ....
  42. ncbi Transmission control for schistosomiasis - why it matters now
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Trends Parasitol 22:575-82. 2006
    ..The next generation of schistosomiasis control can be optimized using new monitoring tools and effective transmission containment...
  43. pmc Epidemiology of schistosomiasis in the People's Republic of China, 2004
    Xiao Nong Zhou
    National Institute of Parasitic Diseases, Shanghai, People s Republic of China
    Emerg Infect Dis 13:1470-6. 2007
    ..This indicates a reduction of 16.1% compared with a nationwide survey conducted in 1995. However, human infection rates increased by 3.9% in settings where transmission is ongoing...
  44. ncbi Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance
    S A Tishkoff
    Department of Biology, Biology Psychology Building, University of Maryland, College Park, MD 20742, USA
    Science 293:455-62. 2001
    ..These results support the hypothesis that malaria has had a major impact on humans only since the introduction of agriculture within the past 10,000 years and provide a striking example of the signature of selection on the human genome...
  45. pmc Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe
    Nicholas Midzi
    National Institute of Health Research, Causeway Harare, Zimbabwe
    BMC Infect Dis 11:169. 2011
    ..This study sought to assess KAP of grade 3 children in relation to schistosomiasis, STHs and malaria in order to establish an effective school based health education for disease transmission control...
  46. pmc Tick infestation on roe deer in relation to geographic and remotely sensed climatic variables in a tick-borne encephalitis endemic area
    G Carpi
    Centre for Alpine Ecology, Viote del Monte Bondone, Trento, Italy
    Epidemiol Infect 136:1416-24. 2008
    ..The surveillance of tick infestation on roe deer, combined with remotely sensed climatic data, could therefore be used as an inexpensive early risk assessment tool of favourable conditions for TBE emergence and persistence in humans...
  47. ncbi A new format of the CATT test for the detection of human African Trypanosomiasis, designed for use in peripheral health facilities
    E Hasker
    Department of Public Health, Epidemiology and Disease Control Unit, Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 15:263-7. 2010
    ....
  48. ncbi Immunogenetic control of antibody responsiveness in a malaria endemic area
    Danielle Carpenter
    Institute of Integrative and Comparative Biology, University of Leeds, Leeds, England
    Hum Immunol 68:165-9. 2007
    ..There was a significant association between the IL1RN alleles and total IgE. Weak evidence for association was present between polymorphisms in the IL10 promoter region and both anti-P falciparum IgE and IgG4 antibodies...
  49. pmc Short-lived IFN-γ effector responses, but long-lived IL-10 memory responses, to malaria in an area of low malaria endemicity
    Jiraprapa Wipasa
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    PLoS Pathog 7:e1001281. 2011
    ..The observations have clear implications for understanding the immunoepidemiology of naturally acquired malaria infections and for malaria vaccine development...
  50. ncbi Seasonality in human salmonellosis: assessment of human activities and chicken contamination as driving factors
    André Ravel
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Saint Hyacinthe, QC, Canada
    Foodborne Pathog Dis 7:785-94. 2010
    ..Attending a barbeque or gardening during the hotter months of the year should be further assessed for their risk...
  51. ncbi Premunition in Plasmodium falciparum infection: insights from the epidemiology of multiple infections
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Trans R Soc Trop Med Hyg 93:59-64. 1999
    ..This has important implications for our understanding of immunity against P. falciparum, its ecological niche, and the epidemiological impact of interventions against it...
  52. ncbi Three Gorges Dam and its impact on the potential transmission of schistosomiasis in regions along the Yangtze River
    Huai Min Zhu
    Department of Etiologic Biology, Second Military Medical University, Shanghai 200433, China
    Ecohealth 5:137-48. 2008
    ....
  53. pmc The burden of cholera in the slums of Kolkata, India: data from a prospective, community based study
    D Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Arch Dis Child 90:1175-81. 2005
    ....
  54. pmc Defining the relationship between Plasmodium falciparum parasite rate and clinical disease: statistical models for disease burden estimation
    Anand P Patil
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Malar J 8:186. 2009
    ..This relationship can help provide an informed basis to define malaria burdens in areas where health statistics are inadequate...
  55. ncbi Comparative evaluation of parasitology and serological tests in the diagnosis of visceral leishmaniasis in India: a phase III diagnostic accuracy study
    S Sundar
    Infectious Diseases Research Laboratory, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Trop Med Int Health 12:284-9. 2007
    ..986). Although DAT-FD and rK-39 strip test were highly sensitive with excellent specificity, the ease of use of the latter makes it most suitable for the diagnosis of VL in the field conditions...
  56. pmc From re-emergence to hyperendemicity: the natural history of the dengue epidemic in Brazil
    Isabel Rodriguez-Barraquer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 5:e935. 2011
    ..While previously the majority of DHF cases occurred among adults, in 2007 53% of cases occurred in children under 15 years old. The reasons for this shift have not been determined...
  57. pmc How much remains undetected? Probability of molecular detection of human Plasmodia in the field
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e19010. 2011
    ..falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI)...
  58. ncbi Control of Taenia solium
    Armando E Gonzalez
    Facultad de Medicina Veterinaria, UNMSM Apartado 03 5013, Lima, Peru
    Acta Trop 87:103-9. 2003
    ..In order to ensure sustainability, any given control strategy towards elimination/eradication of porcine cysticercosis should incorporate economic incentives...
  59. pmc Prevalence of clonorchiasis in southern endemic areas of Korea in 2006
    Shin Hyeong Cho
    Department of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul 122 701, Korea
    Korean J Parasitol 46:133-7. 2008
    ..7% was male. The present findings suggest that clonorchiasis is still highly prevalent among inhabitants in the riverside areas of southern Korea, and it is necessary to implement a systematic control program in the endemic areas...
  60. ncbi Prevalence of tick-borne encephalitis virus in Ixodes ricinus ticks in Finland
    X Han
    Haartman Institute, University of Helsinki, Finland
    J Med Virol 64:21-8. 2001
    ..TBE virus RNA positive ticks were not found in I. ricinus panels consisting of 130 pools (726 ticks) from Helsinki city parks or 41 pools (197 ticks) from Võrmsi Island in Estonia...
  61. pmc Spatial and temporal variation in malaria transmission in a low endemicity area in northern Tanzania
    M J A M Oesterholt
    Joint Malaria Programme, Moshi, Tanzania
    Malar J 5:98. 2006
    ..In this study, data on meteorological, demographic, entomological and parasitological data over the course of a year was collected to describe malaria epidemiology in a single village of low transmission intensity...
  62. ncbi Economic costs of endemic non-filarial elephantiasis in Wolaita Zone, Ethiopia
    Fasil Tekola
    Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 11:1136-44. 2006
    ..It is a major public health problem in countries in tropical Africa, Central America and North India...
  63. ncbi Epidemiological and control aspects of schistosomiasis in Brazilian endemic areas
    J R Coura
    Departamento de Medicina Tropical, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21045 900 Rio de Janeiro, RJ, Brazil
    Mem Inst Oswaldo Cruz 99:13-9. 2004
    ....
  64. pmc Micro-geographic risk factors for malarial infection
    Ward P Myers
    Infectious Disease, Children s Hospital Boston, Boston, USA
    Malar J 8:27. 2009
    ..This study was designed to evaluate whether geographic parameters are associated with malarial infection in the East Sepik province of Papua New Guinea (PNG), a remote area where malaria is a major cause of morbidity and mortality...
  65. pmc Identification of Mycobacterium ulcerans in the environment from regions in Southeast Australia in which it is endemic with sequence capture-PCR
    T Stinear
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Appl Environ Microbiol 66:3206-13. 2000
    ..ulcerans may be transmitted from a point environmental source and demonstrate the utility of magnetic bead sequence capture-PCR for identification of nonculturable microbial pathogens in the environment...
  66. ncbi Short communication: Negative spatial association between lymphatic filariasis and malaria in West Africa
    Louise A Kelly-Hope
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 11:129-35. 2006
    ..To determine the relationship between human lymphatic filariasis, caused by Wuchereria bancrofti, and falciparum malaria, which are co-endemic throughout West Africa...
  67. pmc Respondent-driven sampling on the Thailand-Cambodia border. I. Can malaria cases be contained in mobile migrant workers?
    Amnat Khamsiriwatchara
    Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Bangkok, Thailand
    Malar J 10:120. 2011
    ..In order to limit the spread of malarial drug resistance, the malaria prevention and control programme will need to devise strategies to reach cross-border and mobile migrant populations...
  68. ncbi Echinococcosis in China, a review of the epidemiology of Echinococcus spp
    Zhenghuan Wang
    School of Life Science, East China Normal University, 200062 Shanghai, China
    Ecohealth 5:115-26. 2008
    ..In addition, human activities and their potential influence on the transmission of echinococcosis are also discussed...
  69. pmc Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population
    Simon Metenou
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:916-24. 2009
    ....
  70. ncbi Complexity of the msp2 locus and the severity of childhood malaria, in south-western Nigeria
    O K Amodu
    Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
    Ann Trop Med Parasitol 102:95-102. 2008
    ..It therefore appears that msp2 genotypes are associated with asymptomatic carriage and that children with mono-infections are more likely to develop severe malaria than children with polyinfection...
  71. pmc Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds PO Box 43640 00100, Nairobi, Kenya
    Malar J 8:4. 2009
    ....
  72. ncbi Diagnosis of Mycobacterium ulcerans infection (Buruli ulcer) at a treatment centre in Ghana: a retrospective analysis of laboratory results of clinically diagnosed cases
    Ernestina Mensah-Quainoo
    Ghana Health Service, Ministry of Health, Tema, Ghana
    Trop Med Int Health 13:191-8. 2008
    ..However, being retrospective, this study did not permit sensitivity and negative predictive value analysis...
  73. ncbi Comparison of a polymerase chain reaction and the Kato-Katz technique for diagnosing infection with Schistosoma mansoni
    Luis A Pontes
    Laboratory of Clinical Research, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    Am J Trop Med Hyg 68:652-6. 2003
    ..The efficacy of cure with praziquantel was 87.8% in three parasitologic stool examinations and 75.6% in one PCR survey. These results demonstrate that the PCR assay might be a valuable alternative for diagnosing Schistosoma infections...
  74. ncbi Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 314:1603-6. 2006
    ..Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa...
  75. ncbi Spatial variation of malaria incidence in young children from a geographically homogeneous area with high endemicity
    Benno Kreuels
    Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 197:85-93. 2008
    ..Detailed knowledge of spatial variation of malaria epidemiology and associated risk factors is important for planning and evaluating malaria-control measures...
  76. ncbi Mass treatment and the effect on the load of Chlamydia trachomatis infection in a trachoma-hyperendemic community
    Emily S West
    Dana Center for Preventive Ophthalmology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 46:83-7. 2005
    ..Trachoma remains a leading cause of blindness. Determining the most effective antibiotic treatment strategy is essential for the success of country-based trachoma control programs...
  77. pmc The epidemiology of malaria in adults in a rural area of southern Mozambique
    Alfredo Mayor
    Center for International Health, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Malar J 6:3. 2007
    ..The present study was undertaken to investigate the clinical, parasitological and haematological status of adults exposed to malaria, and to characterize parasites in these individuals who progressively acquire protective immunity...
  78. ncbi Epidemiology and clinical manifestations of Leishmania donovani infection in two villages in an endemic area in eastern Sudan
    E A G Khalil
    Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    Trop Med Int Health 7:35-44. 2002
    ....
  79. pmc Optimal mix of screening and contact tracing for endemic diseases
    Benjamin Armbruster
    Department of Management Science and Engineering, Stanford University, Stanford, CA 94305 4026, USA
    Math Biosci 209:386-402. 2007
    ..Third, these qualitative results hold when we consider unchanged or changed prevalence, and short-term or long-term costs...
  80. ncbi Epidemiology and distribution of tick-borne encephalitis
    Gerhard Dobler
    Department of Microbiology of the German Armed Forces, Neuherbergstr 11, 80937, Munich, Germany
    Wien Med Wochenschr 162:230-8. 2012
    ..Therefore, TBE should be included in the differential diagnosis for all central nervous system diseases inside or outside endemic areas...
  81. pmc Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, P O Box 8045, Kampala, Uganda
    Malar J 7:221. 2008
    ..An assessment of the accuracy of Malaria Pf immuno-chromatographic test (ICT) and description of persistent antigenicity of HRP2 RDTs was undertaken in a hyperendemic area of Uganda...
  82. ncbi The elimination of the onchocerciasis vector from the island of Bioko as a result of larviciding by the WHO African Programme for Onchocerciasis Control
    S Traore
    African Programme for Onchocerciasis Control WHO APOC, 01 BP 549 Ouagadougou 01, Burkina Faso
    Acta Trop 111:211-8. 2009
    ..This led to the successful elimination of the vector. The last biting S. damnosum s.l. was caught in March 2005 and none have been found since then for more than 3 years...
  83. ncbi Longitudinal seroepidemiologic study of visceral leishmaniasis in hyperendemic regions of Bihar, India
    Kamlesh Gidwani
    Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Am J Trop Med Hyg 80:345-6. 2009
    ..However, there was no significant difference in disease conversion among children (5-15 years of age) and adults (> 15 years of age). Seropositivity among asymptomatic persons is not a predictor for development of VL...
  84. ncbi Infectivity of Plasmodium falciparum gametocytes in patients attending rural health centres in western Kenya
    L C Gouagna
    International Centre of Insect Physiology and Ecology ICIPE, P O Box 30772, Nairobi, Kenya
    East Afr Med J 80:627-34. 2003
    ..In this study, the potential of recruiting volunteers and acquiring infectious blood for experimental infections from rural health centers in malaria endemic area was examined through routine patient diagnosis...
  85. ncbi Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distribution
    Angel G Guevara
    Laboratory of Clinical Investigation, Community Services Vozandes, Quito, Ecuador
    Am J Trop Med Hyg 68:222-7. 2003
    ..The data demonstrate that pool screen PCR is an efficient way to monitor transmission in areas subject to control, and to certify an area as free of O. volvulus transmission...
  86. ncbi Visceral leishmaniasis in southeastern Nepal: a cross-sectional survey on Leishmania donovani infection and its risk factors
    Karl Schenkel
    Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 11:1792-9. 2006
    ..To document the frequency of Leishmania donovani infection at community level in a highly endemic region in southeastern Nepal, and to assess socioeconomic and environmental risk factors...
  87. pmc Epidemiological and clinical changes in American tegumentary leishmaniasis in an area of Leishmania (Viannia) braziliensis transmission over a 20-year period
    Lara Jirmanus
    Servico de Imunologia, Complexo Hospitalar Universitário Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
    Am J Trop Med Hyg 86:426-33. 2012
    ..ATL is on the rise in Bahia, with a 10-year periodicity and evolving changes in epidemiology and manifestations of disease...
  88. pmc Usefulness of the rK39-immunochromatographic test, direct agglutination test, and leishmanin skin test for detecting asymptomatic Leishmania infection in children in a new visceral leishmaniasis focus in Amhara State, Ethiopia
    Endalamaw Gadisa
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Am J Trop Med Hyg 86:792-8. 2012
    ..1% (61 of 605). We conclude that the best option to detect asymptomatic infection in this new visceral leishmaniasis-endemic focus is the combined use of the direct agglutination test and the leishmanin skin test...
  89. ncbi Risk factors for canine leishmaniasis in an endemic Mediterranean region
    Sofia Cortes
    Unidade de Leishmanioses, Instituto de Higiene e Medicina Tropical, Rua da Junqueira, 100, 1346 008 Lisboa, Portugal
    Vet Parasitol 189:189-96. 2012
    ..The future of CanL prevention and control rely on an integrated approach involving veterinarians, dog owners and health authorities in order to reduce the canine infection risk and consequently, the human zoonotic visceral leishmaniasis...
  90. doi Rinderpest. Driven to extinction
    Dennis Normile
    Science 319:1606-9. 2008
  91. ncbi A major transition in malaria treatment: the adoption and deployment of artemisinin-based combination therapies
    Andrea Bosman
    World Health Organization, Avenue Appia 20, Geneva, Switzerland
    Am J Trop Med Hyg 77:193-7. 2007
    ..Artemisinins as monotherapies are widely available in the private sector of 47 endemic countries, and their consumption will, if unabated, promote resistance to artemisinins and compromise the effectiveness of ACTs...
  92. pmc Neglected and endemic zoonoses
    Ian Maudlin
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    Philos Trans R Soc Lond B Biol Sci 364:2777-87. 2009
    ..The development of cheap and effective vaccines is no guarantee that these endemic diseases will be eliminated in the near future...
  93. pmc Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis
    Michael K Mwaniki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Box 230, Kilifi, Kenya
    Malar J 9:313. 2010
    ..Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described...
  94. ncbi Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasis
    Francis Anto
    Navrongo Health Research Centre, Navrongo, Ghana
    Trop Med Int Health 16:1112-9. 2011
    ....
  95. pmc Performance of an enzyme-linked immunosorbent assay for detection of Clonorchis sinensis infestation in high- and low-risk groups
    Young Jin Kim
    Department of Laboratory Medicine, School of Medicine, Pusan National University, Busan, South Korea
    J Clin Microbiol 48:2365-7. 2010
    ..9979). The C. sinensis ELISA may be more useful than the intradermal test; however, because of its low specificity, it may not be used independently for the diagnosis of C. sinensis infestation or a prevalence survey in a high-risk group...
  96. ncbi Analysis on value of household contact survey in case detection of leprosy at a low endemic situation in China
    Jianping Shen
    Department of Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, PR China, 210042
    Indian J Dermatol Venereol Leprol 75:152-6. 2009
    ..Leprosy is at a low endemic situation in China, the value of house contact survey in case detection of leprosy becoming a dispute...
  97. pmc Attributable outcomes of endemic Clostridium difficile-associated disease in nonsurgical patients
    Erik R Dubberke
    Washington University School of Medicine, St Louis, Missouri, USA
    Emerg Infect Dis 14:1031-8. 2008
    ..Even in a nonoutbreak setting, CDAD had a statistically significant negative impact on patient illness and death, and the impact of CDAD persisted beyond hospital discharge...
  98. ncbi Crimean-Congo haemorrhagic fever in Eurasia
    Hakan Leblebicioglu
    Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University Medical School, Samsun, Turkey
    Int J Antimicrob Agents 36:S43-6. 2010
    ..The disease is widely distributed in Africa, Europe and Asia, and has become a serious threat to public health in Eurasia. The intention of this review is to summarize the current status of CCHF in Eurasia...
  99. ncbi Evaluation of the 1992-1999 World Bank Schistosomiasis Control Project in China
    W Zhang
    Department of Community Medicine, The University of Hong Kong, 7 Sassoon Road, Hong Kong
    Acta Trop 85:303-13. 2003
    ..However, the achievement of snail control was not so ideal, which calls for rectification for a more applicable and practical strategy of snail control in China...
  100. ncbi Epidemiology and morbidity of Schistosoma mansoni infection in a fishing community along Lake Albert in Uganda
    N B Kabatereine
    Vector Control Division, Ministry of Health, P O Box 1661, Kampala, Uganda
    Trans R Soc Trop Med Hyg 98:711-8. 2004
    ..These observations call for immediate intervention and can help in planning long-term strategies for sustainable morbidity control...
  101. ncbi Plasmodium lactate dehydrogenase assay to detect malarial parasites
    Sonia Malik
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Natl Med J India 17:237-9. 2004
    ..This study was designed to assess the sensitivity and specificity of pLDH assays in detecting and differentiating between various malarial species compared with microscopy...

Research Grants65

  1. Contextual Determinants of HIV/STI Sexual Transmission
    Caroline Fichtenberg; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  2. Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve
    John H Connor; Fiscal Year: 2013
    ..by applicant): Hemorrhagic fever viruses such as Ebola, Marburg and Lassa are responsible for current endemic diseases in Africa and are classified as Category A biothreats by the CDC because of the high fatality that can be ..
  3. RESEARCH TRAINING IN INFECTIOUS DISEASES
    Jack T Stapleton; Fiscal Year: 2013
    ..of humans RELEVANCE: Human suffering due to infectious diseases is widespread, both due to the constant endemic diseases and emerging infectious diseases that can reach epidemic proportions...
  4. PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS-INHIBITOR DESIGN
    Vern Schramm; Fiscal Year: 2003
    ..are expected to protect against the exotoxins and thus ameliorate the damage caused in these childhood and endemic diseases. Transition state structure is determined by measuring kinetic isotope effects with NAD+ substrate labeled in ..
  5. Effect of Parasitic Infection of HIV Diseaes in Malawi
    Mina Hosseinipour; Fiscal Year: 2006
    ..is slowly being introduced, basic medical care remains beyond the reach of most and preventable illnesses and endemic diseases continue to take their toll...
  6. PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    Amira Roess; Fiscal Year: 2005
    ..Continued study and surveillance of the newest epidemics along with endemic diseases, like TB and the flu, are essential to prevent unnecessary suffering and loss of life...
  7. HIV ANTIGEN DISPLAY USING RECOMBINANT FLOATING VESICLES
    Elizabeth Stuart; Fiscal Year: 2001
    ..and associated generation of multiple antibiotic resistance among pathogens, in addition to recalcitrant endemic diseases such as malaria, all indicate that innovative approaches to vaccine development are needed...
  8. Recombinant archaeal organelles of SIV and HIV antigens
    Elizabeth Stuart; Fiscal Year: 2002
    ..tuberculosis, and recalcitrant endemic diseases such as malaria, all indicate innovative approaches to vaccine development are needed...
  9. Latino Eye Health: A Communication Strategy for Diabetes
    Sheila West; Fiscal Year: 2007
    ..Improvements in eye care seeking behaviors should help in avoiding visual loss from diabetic retinopathy and macula edema, the leading causes of visual loss in the working age Latino population. [unreadable] [unreadable]..
  10. Cataract: Health Disparity for Older African-Americans
    Sheila West; Fiscal Year: 2006
    ..These data will advance the goal of reducing health disparity in visual disability from cataract among older African Americans. ..
  11. TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASIS
    Sheila West; Fiscal Year: 2005
    ..abstract_text> ..
  12. Who drives safely? Visual/cognitive predictors in Elders
    Sheila West; Fiscal Year: 2008
    ..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
  13. Yearly Mass Treatment C. Trachomatis: When Can We Stop?
    Sheila West; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTS
    Sheila West; Fiscal Year: 2002
    ..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
  15. AMD AND RISK FACTORS IN A HISPANIC POPULATION
    Sheila West; Fiscal Year: 2003
    ..Such data will advance our understanding of the magnitude of AMD in this ethnic group, and the way in which risk factors relate to AMD in different populations. ..
  16. HUMAN POPULATION GROWTH IMPACT ON S. HAEMATOBIUM
    Charles King; Fiscal Year: 2005
    ....
  17. VACCINE TRIALS USING INDIVIDUAL AND ECOLOGICAL UNITS
    JAMES KOOPMAN; Fiscal Year: 2002
    ..They will also provide insight regarding how different biological effects of vaccines generate different population effects of vaccine programs. ..
  18. URINARY SCHISTOSOMIASIS: INFECTION AND DISEASE
    Charles King; Fiscal Year: 2004
    ..This information, combined with epidemiological modeling of control strategies, will allow accelerated synthesis of the next generation of control programs. ..
  19. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  20. LIVE, ATTENUATED, RECOMBINANT VACCINE - WEST NILE VIRUS
    Thomas Monath; Fiscal Year: 2002
    ..abstract_text> ..
  21. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ....
  22. Plainning malaria training in Zambia
    Thomas Eisele; Fiscal Year: 2009
    ..Tailoring a sustainable program using appropriate technology and a framework of collaboration in support of PMI activities will greatly increase the likelihood of controlling, and perhaps eventually eliminating, malaria in Zambia. ..
  23. TRAINING GRANT IN DERMATOLOGICAL RESEARCH
    Luis Diaz; Fiscal Year: 2006
    ..This competitive grant application requests funding to support the training at the UNC Dermatology Department of the next generation of dermatological investigators. ..
  24. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  25. GROWTH OF B MALAYI IN MURINE MODELS--ROLE OF NK CELLS
    THIRUCHANDURAI RAJAN; Fiscal Year: 2001
    ..Identification of the molecule(s) involved in the interaction could help us formulate a rationale approach to immunoprophylaxis, as well as pharmacology of lymphatic filarial parasites. ..
  26. Utility of rapid diagnostic tests for malaria
    Heidi Hopkins; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. Molecular epidemiology of drug resistant malaria
    MIRIAM LAUFER; Fiscal Year: 2008
    ..abstract_text> ..
  28. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  29. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2007
    ..1 Description, ..
  30. GLUCONEOGENESIS AND GLYCOGENOLYSIS--ROLE OF REGULATION
    Alan Cherrington; Fiscal Year: 2007
    ..The answers obtained by the proposed studies should enhance our understanding of the control of glucose production and pancreatic function in vivo. ..
  31. Exploratory Center for Vaccinology Research (RMI)
    Walter Orenstein; Fiscal Year: 2007
    ..abstract_text> ..
  32. REGULATION OF NET HEPATIC GLUCOSE UPTAKE IN VIVO
    Alan Cherrington; Fiscal Year: 2009
    ..abstract_text> ..
  33. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  34. A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versus
    MIRIAM LAUFER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  37. Antiangiogenic Therapy for AIDS-Associated Lymphomas
    Rosemary Rochford; Fiscal Year: 2008
    ..PROJECT NARRATIVE: The goal of the proposed research is to develop a preclinical model to test new chemotherapies for AIDS-associated lymphomas. [unreadable] [unreadable] [unreadable]..
  38. Malaria: Immunity and Diversity in Low Transmission
    OraLee H Branch; Fiscal Year: 2010
    ..This study will provide this breakthrough and give a model for the increasing emergence of malaria into new geographic regions. ..
  39. A community-level RCT of expedited partner treatment for gonorrhea and chlamydia
    Matthew R Golden; Fiscal Year: 2010
    ..abstract_text> ..
  40. Evolution of Disease: Current patterns and future trends
    Matthew Keeling; Fiscal Year: 2006
    ..The types of trade-offs and constraints seen in the experimental systems can then be used to formulated more biologically mechanistic and more accurate computer models of disease evolution in higher organisms. ..
  41. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
    ..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
  42. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..abstract_text> ..
  43. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  44. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2004
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  45. THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTS
    Loren Miller; Fiscal Year: 2004
    ....
  46. AGING AND IMMUNITY IN TUBERCULOSIS
    Ian Orme; Fiscal Year: 2002
    ....
  47. GENOME EVOLUTION AND THE INSERTION/DELETION SPECTRUM
    Daniel Hartl; Fiscal Year: 2002
    ..Analysis of the limited data presently available for these pseudogenes yields inconclusive, and possibly inconsistent, results. ..
  48. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  49. Socioecological Impacts on Schistosomiasis Risk in Kenya
    Mark Wilson; Fiscal Year: 2005
    ..Our long-term goal is to produce information that can be used to direct control initiatives that will be effectively tailored to local socioeconomic and environmental dynamics. ..
  50. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
  51. The Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne Marrazzo; Fiscal Year: 2006
    ..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
  52. The effect of mixed Plasmodium infections on morbidity
    Ivo Mueller; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. Gastroenteritis and Extreme Weather Events in Elderly
    Elena Naumova; Fiscal Year: 2006
    ..abstract_text> ..
  54. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  55. NEUROTROPIC CYTOMEGALOVIRUS DURING IMMUNOSUPPRESSION
    JON REUTER; Fiscal Year: 2006
    ..abstract_text> ..
  56. Role of non-tuberculous mycobacteria in lung disease
    Jason Stout; Fiscal Year: 2006
    ..Our findings will also assist clinicians in predicting which patients with NTM isolated from the respiratory tract will have NTM pulmonary disease. ..
  57. Regulating I. scapularis and the Role of Entomopathogenic Fungi
    Thomas Daniels; Fiscal Year: 2008
    ..scapularis in lab studies. Long- term health benefits might also accrue with the reduction in pesticide use those results from the availability of an effective biocontrol agent. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Vaccine induced resistance against E. granulosus in dogs
    Wenbao Zhang; Fiscal Year: 2007
    ..granulosus infection by vaccination with the recombinant proteins. We will test humoral and cellular responses generated during vaccination to determine possible correlations of the immune parameters with protection. ..
  59. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. The Effects of HAART on Cancer Incidence in AIDS Cases
    Susan Scheer; Fiscal Year: 2004
    ..Given the respective strengths of the AIDS and cancer registries, we are uniquely situated to perform these investigations. ..
  61. TRYPANOSOMA CRUZI: PATHOGENESIS OF INFECTION
    Herbert Tanowitz; Fiscal Year: 2005
    ..cruzi infection on the activation of NF-KappaB and the outcome of ROS inhibitors in vivo. These studies will delineate the mechanisms by which T. cruzi causes vasculopathy leading to cardiomyopathy. ..