drug contamination

Summary

Summary: The presence of organisms, or any foreign material that makes a drug preparation impure.

Top Publications

  1. ncbi Isolation and characterization of contaminants in recalled unfractionated heparin and low-molecular-weight heparin
    Christian Viskov
    Sanofi Aventis, 13 quai Jules Guesde, Vitry sur Seine, France
    Clin Appl Thromb Hemost 15:395-401. 2009
  2. ncbi DNA barcode identification of black cohosh herbal dietary supplements
    David A Baker
    Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    J AOAC Int 95:1023-34. 2012
  3. ncbi Quality of herbal medicines: challenges and solutions
    Junhua Zhang
    State Key laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    Complement Ther Med 20:100-6. 2012
  4. pmc An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumab
    Roger A Goldberg
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 153:204-208.e1. 2012
  5. ncbi Purity control of some Chinese crude herbal drugs marketed in Italy
    G Mazzanti
    Department of Human Physiology and Pharmacology, University La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Food Chem Toxicol 46:3043-7. 2008
  6. pmc A case of septicaemic anthrax in an intravenous drug user
    Arfon G M T Powell
    Department of Surgical Gastroenterology, Gartnavel General Hospital, Glasgow, UK
    BMC Infect Dis 11:21. 2011
  7. ncbi Adverse effects of herbal drugs in dermatology
    E Ernst
    Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, 25 Victoria Park Road, Exeter EX2 4NT, UK
    Br J Dermatol 143:923-9. 2000
  8. pmc Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines
    Eric S J Harris
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Sci Total Environ 409:4297-305. 2011
  9. pmc Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
    Marco Guerrini
    Istituto di Ricerche Chimiche e Biochimiche G Ronzoni, Città Studi, via Giuseppe, Colombo 81, 20133 Milan, Italy
    Nat Biotechnol 26:669-75. 2008
  10. pmc Lessons learned from the contamination of heparin
    Haiying Liu
    Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Prod Rep 26:313-21. 2009

Research Grants

Detail Information

Publications244 found, 100 shown here

  1. ncbi Isolation and characterization of contaminants in recalled unfractionated heparin and low-molecular-weight heparin
    Christian Viskov
    Sanofi Aventis, 13 quai Jules Guesde, Vitry sur Seine, France
    Clin Appl Thromb Hemost 15:395-401. 2009
    ..The process involved in the production of enoxaparin does not significantly degrade OSCS...
  2. ncbi DNA barcode identification of black cohosh herbal dietary supplements
    David A Baker
    Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    J AOAC Int 95:1023-34. 2012
    ..cimicifuga, A. dahurica, and A. simplex). Manufacturers should routinely test plant material using a reliable assay to ensure accurate labeling...
  3. ncbi Quality of herbal medicines: challenges and solutions
    Junhua Zhang
    State Key laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    Complement Ther Med 20:100-6. 2012
    ..Through the use of modern analytical methods and pharmaceutical techniques, previously unsolved internal issues have become solvable. Standard herbal products can be manufactured from the standard herbal extracts...
  4. pmc An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumab
    Roger A Goldberg
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 153:204-208.e1. 2012
    ..To report a series of patients with Streptococcus endophthalmitis after injection with intravitreal bevacizumab prepared by the same compounding pharmacy...
  5. ncbi Purity control of some Chinese crude herbal drugs marketed in Italy
    G Mazzanti
    Department of Human Physiology and Pharmacology, University La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Food Chem Toxicol 46:3043-7. 2008
    ..Our results, even if obtained from a small number of herbal drugs, show some purity issues and underline the importance of the quality control, particularly for this kind of products whose therapeutic value is not always demonstrated...
  6. pmc A case of septicaemic anthrax in an intravenous drug user
    Arfon G M T Powell
    Department of Surgical Gastroenterology, Gartnavel General Hospital, Glasgow, UK
    BMC Infect Dis 11:21. 2011
    ..In 2008, there were 574 drug related deaths in Scotland, of which 336 were associated with heroin and or morphine. We report a rare case of septicaemic anthrax caused by injecting heroin contaminated with anthrax in Scotland...
  7. ncbi Adverse effects of herbal drugs in dermatology
    E Ernst
    Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, 25 Victoria Park Road, Exeter EX2 4NT, UK
    Br J Dermatol 143:923-9. 2000
    ..It is concluded that adverse effects of herbal medicines are an important albeit neglected subject in dermatology, which deserves further systematic investigation...
  8. pmc Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines
    Eric S J Harris
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Sci Total Environ 409:4297-305. 2011
    ....
  9. pmc Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
    Marco Guerrini
    Istituto di Ricerche Chimiche e Biochimiche G Ronzoni, Città Studi, via Giuseppe, Colombo 81, 20133 Milan, Italy
    Nat Biotechnol 26:669-75. 2008
    ..Our analysis suggests effective screening methods that can be used to determine whether or not heparin lots contain the contaminant reported here...
  10. pmc Lessons learned from the contamination of heparin
    Haiying Liu
    Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Prod Rep 26:313-21. 2009
    ..Effective assays, which can detect both known and unknown contaminants, are required to monitor the quality of heparin. Safer and better-regulated processes are needed for heparin production...
  11. ncbi Effect of Ca2+ on the 1H NMR chemical shift of the methyl signal of oversulphated chondroitin sulphate, a contaminant in heparin
    Ian McEwen
    Medical Products Agency, Box 26, SE 75103 Uppsala, Sweden
    J Pharm Biomed Anal 49:816-9. 2009
    ..This Ca2+ effect can be used for OSCS identification as well as to facilitate quantification...
  12. ncbi Analysis of crude heparin by (1)H NMR, capillary electrophoresis, and strong-anion-exchange-HPLC for contamination by over sulfated chondroitin sulfate
    David A Keire
    Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market St, Saint Louis, MO 63101, USA
    J Pharm Biomed Anal 51:921-6. 2010
    ..5M NaCl solution. This SAX-HPLC approach gave a weight percent LOD of 0.02% and a LOQ of 0.07% and had better performance characteristics than that of the protocol used for APIs...
  13. ncbi Lethal outbreak of infection with Clostridium novyi type A and other spore-forming organisms in Scottish injecting drug users
    Christopher C McGuigan
    Greater Glasgow NHS Board, Scotland
    J Med Microbiol 51:971-7. 2002
    ..The findings are consistent with an infection resulting from injection into soft tissue of acidified heroin contaminated with spore-forming bacteria. Toxin production led to a severe local reaction and, in many, multi-system failure...
  14. ncbi Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961
    Rochelle Cutrone
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois, USA
    Cancer Res 65:10273-9. 2005
    ..Moreover, our results indicate possible geographic differences in SV40 exposure and offer a possible explanation for the different percentage of SV40-positive tumors detected in some laboratories...
  15. pmc Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
    ....
  16. ncbi Lack of herbal supplement characterization in published randomized controlled trials
    Peter M Wolsko
    Kaiser Permanente Medical Group, Denver, CO 80020, USA
    Am J Med 118:1087-93. 2005
    ..We assessed the extent to which recently published randomized controlled trials of herbal supplements characterized and verified the content of the supplement under study...
  17. pmc Manslaughter by fake artesunate in Asia--will Africa be next?
    Paul N Newton
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    PLoS Med 3:e197. 2006
  18. pmc Oversulfated chondroitin sulfate interaction with heparin-binding proteins: new insights into adverse reactions from contaminated heparins
    Boyangzi Li
    Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Biochem Pharmacol 78:292-300. 2009
    ..In contrast to heparin, oversulfated chondroitin sulfate tightly binds factor XIIa suggesting a biochemical mechanism for the factor XIIa-based enhancement of vasoactive bradykinin production...
  19. ncbi Inhibition of Taq polymerase as a method for screening heparin for oversulfated contaminants
    Cecilia Tami
    Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drugs Evaluation and Research, Food and Drug Administration, Rockville Pike, Bethesda, MD 20892, USA
    Biomaterials 29:4808-14. 2008
    ..This method requires less than 100 miliUnits (mU) of heparin as starting material, therefore avoiding the need to lyophilize and concentrate samples, and has a limit of detection of <1 ng for all oversulfated GAGs tested...
  20. ncbi Epoetin-associated pure red cell aplasia in patients with chronic kidney disease: solving the mystery
    Katia Boven
    Service d Hematologie Biologique, Hopital Hotel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris cedex 4, France
    Nephrol Dial Transplant 20:iii33-40. 2005
    ..In conclusion, these data strongly suggest that leachates were the critical contributory factor in the increased incidence of antibody-mediated PRCA attributed to EPREX/ERYPO...
  21. pmc Analysis of particulate contaminations of infusion solutions in a pediatric intensive care unit
    Thomas Jack
    Department of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany
    Intensive Care Med 36:707-11. 2010
    ....
  22. ncbi DNA barcodes for discriminating the medicinal plant Scutellaria baicalensis (Lamiaceae) and its adulterants
    Xiaorong Guo
    Institute of Ecology and Geobotany, School of Life Sciences, Yunnan University, Kunming 650091, P R China
    Biol Pharm Bull 34:1198-203. 2011
    ..The DNA barcoding technique could be applied to the quality control of "Huang Qin"-based medicinal preparations and to the management of medicinal herb trade in the markets...
  23. ncbi Rapid identification of sibutramine in dietary supplements using a stepwise approach
    D Csupor
    Department of Pharmacognosy, University of Szeged, Szeged, Hungary
    Pharmazie 68:15-8. 2013
    ..The multistep method proposed by the authors allows the quick identification of sibutramine in counterfeit samples in laboratories with different instrumentation...
  24. pmc Strategies for the assessment of protein aggregates in pharmaceutical biotech product development
    John den Engelsman
    Biological and Sterile Product Development, MSD, Oss, The Netherlands
    Pharm Res 28:920-33. 2011
    ..Moreover, we elaborate on why these methods should be used during product development and make recommendations to the biotech community with regard to strategies for their application during the development of protein therapeutics...
  25. ncbi Molecular authentication of the ethnomedicinal plant Sabia parviflora and its adulterants by DNA barcoding technique
    Xue Yi Sui
    Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P R China
    Planta Med 77:492-6. 2011
    ..Our results suggest that the three candidate barcodes can be used for the identification of S. parviflora and to distinguish it from common substitutes or adulterants...
  26. ncbi Particulate matter contamination of intravenous antibiotics aggravates loss of functional capillary density in postischemic striated muscle
    Hans Anton Lehr
    Institute of Pathology, University of Mainz, Germany
    Am J Respir Crit Care Med 165:514-20. 2002
    ..e., after trauma, major surgery, or sepsis) and thus predispose to complications such as acute respiratory distress syndrome or multiple organ failure...
  27. ncbi Substandard medicines in resource-poor settings: a problem that can no longer be ignored
    J M Caudron
    Medecins Sans Frontieres, Geneva, Switzerland, and AEDES Fondation, Brussels, Belgium
    Trop Med Int Health 13:1062-72. 2008
    ..Governments in rich countries should not tolerate the export of substandard pharmaceutical products to poor countries, while developing country governments should improve their ability to detect substandard medicines...
  28. pmc In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial
    Thomas Jack
    Department of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Intensive Care Med 38:1008-16. 2012
    ..Particulate contamination due to infusion therapy carries a potential health risk for intensive care patients...
  29. ncbi Protein isolated from biopharmaceutical formulations cannot be used for comparative studies: Follow-up to "a case study using Epoetin Alfa from Epogen and EPREX"
    G A Heavner
    Centocor R and D, 145 King of Prussia Road, Radnor, PA 19087, USA
    J Pharm Sci 96:3214-25. 2007
    ....
  30. ncbi Infantile lead poisoning from an Asian tongue powder: a case report & subsequent public health inquiry
    Alan D Woolf
    Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Clin Toxicol (Phila) 46:841-4. 2008
    ..Lead poisoning from novel environmental sources continues to present a challenge to clinicians who treat infants and children...
  31. ncbi Adulterants in illicit drugs: a review of empirical evidence
    Claire Cole
    Liverpool John Moores University, Centre for Public Health, Liverpool, United Kingdom
    Drug Test Anal 3:89-96. 2011
    ..As part of that strategy, analyses performed for adulterants needs to be encouraged, which are considerably limited in number and scope at the moment...
  32. ncbi Presence of infectious RD-114 virus in a proportion of canine parvovirus isolates
    Rokusuke Yoshikawa
    Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Vet Med Sci 74:347-50. 2012
    ..We also found that RD-114 virus was stable physically and is capable of retaining its infectivity for a long period at -80°C...
  33. ncbi Influence of the glass packing on the contamination of pharmaceutical products by aluminium. Part III: Interaction container-chemicals during the heating for sterilisation
    Denise Bohrer
    Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, Brasil
    J Trace Elem Med Biol 17:107-15. 2003
    ..Experiments with complexing agents for Al allowed to conclude that the higher the stability constant of the complex, the higher the Al release from the container material...
  34. ncbi Metals in herbal drugs from Himalayan region
    Yogesh B Pakade
    Hill Area Tea Science Division, Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research CSIR, Palampur 176061, India
    Bull Environ Contam Toxicol 86:133-6. 2011
    ..The studied toxic elements were present in the herbal drugs (0.2-8.34 mg/kg As, 0.11-0.48 mg/kg Cd, 2.5-6.0 mg/kg Pb). Zinc was found in the range 7-32 mg/kg and all the samples were free from mercury contamination...
  35. ncbi Interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions
    Annabelle P Villalobos
    Biotech Development, Global Biological Supply Chain, 100 Route 202 South, Raritan, New Jersey 08869, USA
    Pharm Res 22:1186-94. 2005
    ..The purpose of this work was to repeat previously published studies in a more controlled manner and to define the precise nature of the interactions between polysorbate 80 and erythropoietin...
  36. ncbi Comparative evaluation of in vitro and in vivo assays for the detection of reticuloendotheliosis virus as a contaminant in a live virus vaccine of poultry
    A M Fadly
    USDA Agricultural Research Service, East Lansing, MI 48823, USA
    Avian Dis 41:695-701. 1997
    ....
  37. ncbi Meeting report on protein particles and immunogenicity of therapeutic proteins: filling in the gaps in risk evaluation and mitigation
    John Carpenter
    University of Colorado, Boulder, CO, USA
    Biologicals 38:602-11. 2010
    ....
  38. doi Iatrogenic Creutzfeldt-Jakob disease 22 years after human growth hormone therapy: clinical and radiological features
    M Furtner
    J Neurol Neurosurg Psychiatry 79:229-31. 2008
  39. ncbi Impact of illegal trade on the quality of epoetin alfa in Thailand
    Fotis Fotiou
    Global Pharmaceutical Supply Group, Johnson and Johnson, Horsham, Pennsylvania, USA
    Clin Ther 31:336-46. 2009
    ..An investigation of anti-erythropoietin antibody-mediated pure red cell aplasia in Thailand found evidence of drug smuggling, which may have serious safety implications...
  40. ncbi Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition
    Emmanuelle Advenier
    Service de Pharmacie, Hopital Necker Enfants Malades, Pharmacie Centrale des Hôpitaux de Paris, 149 rue de Sevres, 75015 Paris, France
    J Pediatr Gastroenterol Nutr 36:448-53. 2003
    ..The aim of the present study is to determine the aluminum contamination of parenteral nutrition solutions and their components, and to assess the aluminum status of children on long-term parenteral nutrition...
  41. ncbi Influence of the glass packing on the contamination of pharmaceutical products by aluminium. Part II: amino acids for parenteral nutrition
    D Bohrer
    Departamento de Quimica, Universidade Federal de Santa Maria, RS, Brazil
    J Trace Elem Med Biol 15:103-8. 2001
    ..The resuLts demonstrated that the contamination is an ongoing process due to the presence of aluminium in glass combined with the affinity of some amino acids for this element...
  42. pmc Candidate cell substrates, vaccine production, and transmissible spongiform encephalopathies
    Pedro Piccardo
    University of Edinburgh, Easter Bush, UK
    Emerg Infect Dis 17:2262-9. 2011
    ..In contrast, animals inoculated with cells exposed to the BSE agent remained asymptomatic. All cell lines we studied resisted infection with 3 TSE agents, including the BSE agent...
  43. ncbi An investigation into the microflora of heroin
    J McLauchlin
    Central Public Health Laboratory, Communicable Disease Surveillance Centre, London
    J Med Microbiol 51:1001-8. 2002
    ..subtilis alone and in one sample B. pumilus alone. C. botulinum and C. novyi were not isolated from any of the heroin samples. Recommendations for the optimal examination of the microflora of heroin are given...
  44. ncbi Determination of impurities in heparin by capillary electrophoresis using high molarity phosphate buffers
    Todd Wielgos
    Baxter Healthcare Corporation, Round Lake, IL 60073, USA
    J Pharm Biomed Anal 49:319-26. 2009
    ..A high speed, high resolution version of the method was developed using 600mM lithium phosphate, pH 2.8 in a 21.5cm x 25microm i.d. capillary which provided limits of detection for OSCS that were below 0.1%...
  45. pmc Outbreak of adverse reactions associated with contaminated heparin
    David B Blossom
    Epidemic Intelligence Service Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 359:2674-84. 2008
    ..Preliminary findings suggested that heparin was a possible cause of the reactions...
  46. ncbi Authentication of the family Polygonaceae in Chinese pharmacopoeia by DNA barcoding technique
    Jingyuan Song
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, 151 Malianwa North Road, Haidian District, Beijing 100193, PR China
    J Ethnopharmacol 124:434-9. 2009
    ..Medicinal plants belonging to the family Polygonaceae in Chinese pharmacopoeia possess important medicinal efficacy in traditional Chinese medicines...
  47. ncbi Herbal remedies
    Peter A G M De Smet
    Scientific Institute Dutch Pharmacists, The Hague, The Netherlands
    N Engl J Med 347:2046-56. 2002
  48. ncbi Lead in pharmaceutical products and dietary supplements
    John F Kauffman
    U S Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St, St Louis, MO 63101, USA
    Regul Toxicol Pharmacol 48:128-34. 2007
    ..Uniform lead limits that reflect current manufacturing capabilities are needed to insure the lowest achievable exposure to lead from these products...
  49. ncbi Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis
    Govert W Somsen
    Department of Biomedical Analysis, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    J Chromatogr A 1216:4107-12. 2009
    ..The CE method is shown to be repeatable and linear (R(2)>0.99) for OSCS, heparin and DS. CE analyses of OSCS-contaminated heparin samples and different heparin standards further demonstrate the utility of the method...
  50. ncbi Low incidence of SV40-like sequences in ependymal tumours
    F J Reuther
    Department of Pathology, University Hospitals of Ulm, Ulm, Germany
    J Pathol 195:580-5. 2001
    ..These differences may reflect different degrees of exposure to SV40-contaminated polio vaccine...
  51. ncbi Screening of heparin API by near infrared reflectance and Raman spectroscopy
    John A Spencer
    Division of Pharmaceutical Analysis, Food and Drug Administration, Center for Drug Evaluation and Research, St Louis, Missouri 63101, USA
    J Pharm Sci 98:3540-7. 2009
    ..These technologies are meant for screening purposes and not meant to replace either of the methods (capillary electrophoresis and NMR) currently required by USP and FDA...
  52. ncbi Combined quantitative (1)H and (13)C nuclear magnetic resonance spectroscopy for characterization of heparin preparations
    M Guerrini
    G Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy
    Semin Thromb Hemost 27:473-82. 2001
    ..Contaminants arising from industrial preparation processes are also detectable...
  53. ncbi Complications of traditional Chinese/herbal medicines (TCM)--a guide for perplexed oncologists and other cancer caregivers
    Joanne Chiu
    Division of Hematology Oncology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Pokfulam, Hong Kong
    Support Care Cancer 17:231-40. 2009
    ..If unrecognized, these problems may be misattributed to conventional treatment toxicity or disease progression, and remedial action may be inappropriate or delayed...
  54. ncbi Particulate and microbial contamination in in-use admixed parenteral nutrition solutions
    Shigeharu Oie
    Department of Pharmacy, Yamaguchi University Hospital, 1 1 1 Minamikogushi, Ube 755 8505, Japan
    Biol Pharm Bull 28:2268-70. 2005
    ..01). On the other hand, none of the 199 samples showed bacteria or fungi/5 ml residual solution. Measures against particulate contamination of admixed parenteral nutrition solutions are necessary...
  55. ncbi Human and animal vaccine contaminations
    Paul Pierre Pastoret
    Publications Department, World Organisation for Animal Health, 12, rue de Prony, 75017 Paris, France
    Biologicals 38:332-4. 2010
    ....
  56. ncbi Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE
    Zhenqing Zhang
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    J Pharm Sci 98:4017-26. 2009
    ..5-10%. Most of these heparinoids were stable to nitrous acid treatment suggesting its utility for evaluating impurities and contaminants in heparin API...
  57. ncbi A sensitive ELISA for the detection of bovine crude heparin in porcine heparin
    A Levieux
    INRA, Station de Recherches sur la Viande, Immunochimie, Theix, , France
    J Immunoassay Immunochem 22:323-36. 2001
    ..Taking into account the variability of the background obtained for 10 crude and 9 pure porcine heparins from known origin, the detection level was 5 ppm. Ovine and caprine crude heparins cross-reacted slightly (6-17 ppm)...
  58. pmc Bradykinin forming capacity of oversulfated chondroitin sulfate contaminated heparin in vitro
    Albert Adam
    Faculty of Pharmacy, Universite de Montreal, 2900, Boulevard E Montpetit, Montreal, QC H3T 1J4, Canada
    Biomaterials 31:5741-8. 2010
    ....
  59. ncbi Structure elucidation and biological activity of the oversulfated chondroitin sulfate contaminant in Baxter heparin
    Jeff McKee
    Baxter Healthcare, 25212 W Illinois Rt 120, WG2 1S, Round Lake, IL 60073, USA
    J Clin Pharmacol 50:1159-70. 2010
    ..These data provide insight into the etiology of the adverse events, particularly refractory hypotension, observed in patients who were exposed to heparin contaminated with OSCS...
  60. ncbi Toxic heavy metals and undeclared drugs in Asian herbal medicines
    Edzard Ernst
    Dept of Complementary Medicine, School of Sport and Health Sciences, University of Exeter, UK
    Trends Pharmacol Sci 23:136-9. 2002
    ..However, the majority of the data is anecdotal and insufficient to define prevalence figures. Ways ought to be found to maximize consumer safety...
  61. ncbi The tainted heparin story: an update
    Marco Guerrini
    Institute for Chemical and Biochemical Research, NMR Centre, Milan 20133, Italy
    Thromb Haemost 102:907-11. 2009
    ..As such, these techniques are powerful tools for the analysis and assessment of heparin preparations...
  62. ncbi Botanical medicines--the need for new regulations
    Donald M Marcus
    Baylor College of Medicine Houston, TX 77030, USA
    N Engl J Med 347:2073-6. 2002
  63. ncbi Analysis of heparin sodium by SAX/HPLC for contaminants and impurities
    Michael L Trehy
    Food and Drug Administration, Division of Pharmaceutical Analysis, Saint Louis, MO 63101, USA
    J Pharm Biomed Anal 49:670-3. 2009
    ..1% and 0.8%, respectively. This manuscript is not a policy document and is not intended to replace either of the methods (capillary electrophoresis and NMR) currently required by the FDA...
  64. ncbi Molecular and infectivity studies of porcine circovirus in vaccines
    Shasta D McClenahan
    Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA CBER, Bethesda, MD 20892 4555, United States
    Vaccine 29:4745-53. 2011
    ..In these vaccines, molecular characterization of PCV nucleic acids was useful for predicting the results of cell culture assays...
  65. ncbi Identification of a simple and sensitive microplate method for the detection of oversulfated chondroitin sulfate in heparin products
    Shawn Bairstow
    Technology Resources, Baxter Healthcare, 25212 W Illinois Rt 120, Round Lake, IL 60073, USA
    Anal Biochem 388:317-21. 2009
    ..1%, well below the NOEL. This kit may provide a useful method to test heparin products for contamination with oversulfated GAG derivatives...
  66. ncbi Endogenous retroviruses as potential hazards for vaccines
    Takayuki Miyazawa
    Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Biologicals 38:371-6. 2010
    ....
  67. ncbi Composition of OSCS-contaminated heparin occurring in 2008 in batches on the German market
    Tanja Beyer
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Eur J Pharm Sci 40:297-304. 2010
    ..0. The presented analysis of a representative set of heparin samples proves the suitability of 1H NMR spectroscopy for the quality control of heparin of both glycosaminoglycans and residual solvents...
  68. ncbi Improved impurity fingerprinting of heparin by high resolution (1)H NMR spectroscopy
    Peter Bigler
    University of Berne, Department of Chemistry and Biochemistry, Laboratory for NMR Spectroscopy, Bern, Switzerland
    J Pharm Biomed Anal 49:1060-4. 2009
    ....
  69. ncbi Methamphetamine impurity profiling using a 0.32 mm i.d. nonpolar capillary column
    Hiroyuki Inoue
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa shi, Chiba 277 0882, Japan
    Forensic Sci Int 135:42-7. 2003
    ..The results indicate that the present method would be useful for methamphetamine impurity profiling...
  70. ncbi Heparins: process-related physico-chemical and compositional characteristics, fingerprints and impurities
    Lino Liverani
    R and D Laboratories, Opocrin SpA, Corlo di Formigine Modena, Italy
    Thromb Haemost 102:846-53. 2009
    ....
  71. ncbi Lead-induced peripheral neuropathy following Ayurvedic medication
    Surjit Singh
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Sci 63:408-10. 2009
    ..He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal. The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning...
  72. pmc Orthogonal analytical approaches to detect potential contaminants in heparin
    Marco Guerrini
    Istituto di Richerche Chimiche e Biochimiche G Ronzoni, via Giuseppe Colombo 81, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16956-61. 2009
    ..We show that given the complexity of heparin samples, and the requirement to ensure their purity and safety, use of orthogonal analytical techniques is effective at detecting an array of potential contaminants that could be present...
  73. ncbi Contamination of infectious RD-114 virus in vaccines produced using non-feline cell lines
    Rokusuke Yoshikawa
    Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Biologicals 39:33-7. 2011
    ..To exclude RD-114 virus from live attenuated vaccines, we must pay attention to the contamination of seed viruses with RD-114 virus in addition to avoiding feline cell lines producing RD-114 virus when manufacturing vaccines...
  74. pmc Identification and characterization of avian retroviruses in chicken embryo-derived yellow fever vaccines: investigation of transmission to vaccine recipients
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 77:1105-11. 2003
    ..The absence of evidence of infection with ALV-E or EAV in 43 YF vaccine recipients suggests low risks for transmission of these viruses, further supporting the safety of these vaccines...
  75. ncbi Chinese proprietary medicine in Singapore: regulatory control of toxic heavy metals and undeclared drugs
    H L Koh
    Department of Pharmacy, National University of Singapore
    Drug Saf 23:351-62. 2000
    ....
  76. ncbi Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, 6120 Executive Blvd, EPS 8010 Rockville, MD 20892, USA
    Expert Rev Vaccines 4:197-206. 2005
    ....
  77. ncbi Characterisation of Ag1, the major species-specific contaminant of bovine crude heparin, and its identification as an aprotinin/heparin complex
    Vincent Rivera
    INRA, Station de Recherches sur la Viande, Immunochimie, Theix, 63122 Saint Genes Champanelle, France
    J Pharm Biomed Anal 29:443-58. 2002
    ....
  78. pmc Case report: potential arsenic toxicosis secondary to herbal kelp supplement
    Eric Amster
    School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Environ Health Perspect 115:606-8. 2007
    ..Medicinal use of dietary herbal supplements can cause inadvertent arsenic toxicosis...
  79. ncbi Particulate and microbial contamination in in-use admixed intravenous infusions
    Katsuhiro Yorioka
    Department of Pharmacy, Saiseikai Yamaguchi University Hospital, Japan
    Biol Pharm Bull 29:2321-3. 2006
    ..No microbial contamination was observed in any of the residual solutions of 5 types of admixture...
  80. ncbi Phage passage after extended processing in small-virus-retentive filters
    Scott Lute
    Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA
    Biotechnol Appl Biochem 47:141-51. 2007
    ..Validation of filter performance with phages such as pp7 or PhiX-174 as models for small mammalian viruses represents an attractive alternative to the current practice...
  81. ncbi A multistate outbreak of Serratia marcescens bloodstream infection associated with contaminated intravenous magnesium sulfate from a compounding pharmacy
    Rebecca H Sunenshine
    Centers for Disease Control and Prevention, Arizona Dept of Health Services, 150 N 18th Ave, Ste 150, Phoenix, AZ 85007, USA
    Clin Infect Dis 45:527-33. 2007
    ..An investigation was initiated to determine whether there was a common underlying cause...
  82. pmc A collaborative epidemiological investigation into the criminal fake artesunate trade in South East Asia
    Paul N Newton
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    PLoS Med 5:e32. 2008
    ....
  83. doi Trying times at the FDA--the challenge of ensuring the safety of imported pharmaceuticals
    Stuart O Schweitzer
    Department of Health Services at the UCLA School of Public Health, Los Angeles, USA
    N Engl J Med 358:1773-7. 2008
  84. doi Playing "kick the FDA"--risk-free to players but hazardous to public health
    Alastair J J Wood
    Symphony Capital, New York, USA
    N Engl J Med 358:1774-5. 2008
  85. ncbi Hepatitis C virus infections from a contaminated radiopharmaceutical used in myocardial perfusion studies
    Priti R Patel
    Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 296:2005-11. 2006
    ..Hepatitis C virus (HCV) transmission has not been reported previously in the setting of nuclear imaging studies...
  86. ncbi Outbreak of Serratia marcescens infections following injection of betamethasone compounded at a community pharmacy
    Rachel Civen
    Los Angles County Department of Health Services, Acute Communicable Disease Control Program, Los Angeles, CA 90012, USA
    Clin Infect Dis 43:831-7. 2006
    ..In June 2001, following the report of 4 patients with Serratia marcescens meningitis who received epidural injections of betamethasone compounded at a community pharmacy, we initiated an outbreak investigation...
  87. ncbi Impact of United States Pharmacopeia chapter 797: results of a national survey
    Timothy A Candy
    The Ohio State University OSU, USA
    Am J Health Syst Pharm 63:1336-43. 2006
    ..The initial response of the pharmacy profession to United States Pharmacopeia (USP) chapter 797 and the current state of hospital pharmacy practice as it relates to implementing this chapter were studied...
  88. ncbi Use of bacteriophages as surrogates for mammalian viruses
    M McAlister
    Scientific and Laboratory Services SLS, Pall Corporation, Port Washington, NY 11050, USA
    Dev Biol (Basel) 118:89-98. 2004
    ..We propose that well-characterised bacteriophage, such as PP7 and PR772 can be used as models for mammalian viruses if the virus removal mechanism is based on size exclusion...
  89. ncbi Real time quantitative PCR as a method to evaluate xenotropic murine leukemia virus removal during pharmaceutical protein purification
    Liming Shi
    Process Sciences, Genentech, Inc, 1 DNA Way, South San Francisco, CA, USA
    Biotechnol Bioeng 87:884-96. 2004
    ..Its availability should greatly facilitate and reduce the cost of viral clearance evaluations for new biologic product development...
  90. ncbi USP chapter 797: establishing a practice standard for compounding sterile preparations in pharmacy
    Eric S Kastango
    Clinical IQ, LLC, Florham Park, NJ 07932, USA
    Am J Health Syst Pharm 61:1928-38. 2004
  91. ncbi Quality and stability of TB medicines: let the buyer beware!
    Richard Laing
    Int J Tuberc Lung Dis 8:1043-4. 2004
  92. ncbi Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Natl Cancer Inst 95:532-9. 2003
    ..To clarify whether SV40 infection increases risk of these cancers or of cancers arising in children, we examined cancer incidence in three Danish birth cohorts...
  93. ncbi Pharmacopoeial quality of drugs supplied by Nigerian pharmacies
    R B Taylor
    School of Pharmacy, The Robert Gordon University, Schoolhill, AB10 1FR, Aberdeen, UK
    Lancet 357:1933-6. 2001
    ..Substandard drugs sold in the pharmacies of less-developed countries could contribute to global microbial resistance and therapeutic failure of infectious diseases...
  94. ncbi Acanthamoeba keratitis and contact lens disinfecting solutions
    K Tzanetou
    Microbiology Laboratory, General Hospital of Athens G Gennimatas, Athens, Greece
    Ophthalmologica 220:238-41. 2006
    ..To report cases of culture-proved Acanthamoeba keratitis in Greece over a 10-year period and to evaluate the effectiveness of the commonly used commercial contact lens disinfecting systems in clinical cases of Acanthamoeba keratitis...
  95. pmc Pseudomonas putida septicemia in a special care nursery due to contaminated flush solutions prepared in a hospital pharmacy
    Joseph F Perz
    Centers for Disease Control and Prevention, Office of Workforce and Career Development, Epidemic Intelligence Service, Atlanta, Georgia 30333, USA
    J Clin Microbiol 43:5316-8. 2005
    ..These findings highlight the need for compliance with current standards of aseptic technique and quality assurance during the preparation of compounded sterile products...
  96. ncbi Effect of storage temperatures and time on the efficacy of multipurpose solutions for contact lenses
    Polly Leung
    Biomedical Science Section, School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
    Ophthalmic Physiol Opt 24:218-24. 2004
    ..To determine the effect of storage time and temperature on the efficacy of four multipurpose solutions for soft contact lenses...
  97. ncbi Lack of serologic evidence for prevalent simian virus 40 infection in humans
    Joseph J Carter
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 95:1522-30. 2003
    ..To test this hypothesis, we screened human sera for antibodies to SV40 using direct and competitive enzyme-linked immunosorbent assays (ELISAs)...
  98. pmc Murder by fake drugs
    Paul N Newton
    BMJ 324:800-1. 2002
  99. ncbi Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state
    Melissa R Held
    Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA
    Pediatrics 118:e212-5. 2006
    ..Proper quality controls at a local and national level are important for ensuring safe delivery of compounded medications to patients in all settings, including those outside health care facilities...
  100. ncbi Is there an association between SV40 contaminated polio vaccine and lymphoproliferative disorders? An age-period-cohort analysis on Norwegian data from 1953 to 1997
    Guri Olsen Thu
    The Cancer Registry of Norway Institute of Population based Cancer Research, Montebello, Oslo, Norway
    Int J Cancer 118:2035-9. 2006
    ..Thus, our data do not support the hypothesis of an association between the vaccine and any subgroup of lymphoproliferative diseases...
  101. ncbi Absence of SV40 in Austrian tumors correlates with low incidence of mesotheliomas
    Andreas Leithner
    Department of Orthopedic Surgery, Karl Franzens University, Graz, Austria
    Cancer Biol Ther 1:375-9. 2002
    ..Our findings support the notion that: 1) polio vaccination is the main source for SV40 in human populations, 2) Austria was not exposed to SV40, and 3) its absence correlates with the low incidence of mesotheliomas in Austria...

Research Grants46

  1. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY G SAKHRANI; Fiscal Year: 2013
    ..The proposed TriboGlide(R) system will be the first silicone-free system for glass prefilled syringes that overcomes the problems of lubricant migration and drug contamination.
  2. Validation of LC-MS/MS analyses of animal tissue and feed matrices for toxicants
    CYNTHIA LYNN GASKILL; Fiscal Year: 2013
    ..safety of human and animal health by investigating potential adverse events involving animal feed or animal drug contamination or adulteration...
  3. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY SAKHRANI; Fiscal Year: 2009
    ..The proposed TriboGlide system will be the first silicone oil-free system for glass prefilled syringes that overcomes the problems of lubricant migration and drug contamination.
  4. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
    ..abstract_text> ..
  5. The Bioavilaibility of Folate in Humans
    Richard van Breemen; Fiscal Year: 2004
    ..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..
  6. HPLC time-of-flight mass spectrometer for accurate mass measurements
    Richard van Breemen; Fiscal Year: 2007
    ..to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs [unreadable] [unreadable] [unreadable]..
  7. Mechanisms of prostate cancer prevention by lycopene
    Richard van Breemen; Fiscal Year: 2007
    ..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. [unreadable] [unreadable] [unreadable]..
  8. 2D-HPLC-Tandem Mass Spectrometer for Proteomics
    Richard van Breemen; Fiscal Year: 2005
    ..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
  9. Microglial Cell Activation by Thrombin in Stroke
    Jonathan Weinstein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  11. SV40 Pathogenesis of Human Infections
    JANET BUTEL; Fiscal Year: 2008
    ..This new information will allow better understanding of the biology of SV40 human infections and may provide insights into the mechanisms of SV40 involvement in human malignancies. [unreadable] [unreadable]..
  12. Plasmodium Falciparum Metal Metabolism
    David Sullivan; Fiscal Year: 2009
    ..Plasmodium parasitism provides a comparison of "simple" erythrocyte cell to more complex infected cell. ..
  13. Case CFAR Meeting: HIV Pathogenesis
    Michael Lederman; Fiscal Year: 2006
    ..Presentation sessions will be Cellular Restrictions Factors; Latency; Protection from HIV Infection; Immune Pathogenesis; and Vaccines. ..
  14. Impact of Drug Policy Reform on the HIV Risk Environment among IDUs in Tijuana
    Steffanie A Strathdee; Fiscal Year: 2010
    ....
  15. N-acetylcysteine pharmacokinetics--hemodialysis patients
    Richard Ward; Fiscal Year: 2006
    ..abstract_text> ..
  16. Club Drugs/Resource Inequity/Health Risk in Urban Youth
    Jean Schensul; Fiscal Year: 2005
    ..The study promises to produce new analytic and theoretical insights into the diffusion of new drugs into already saturated urban youth drug markets and the consequences of their use. ..
  17. Topical Immune modulatory strategies to prevent HIV transmission
    Michael Lederman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Direct Enantiomer Separation in Immunoaffinity Systems
    Oliver Hofstetter; Fiscal Year: 2003
    ..Chromatographic parameters will be optimized in order to adjust separation conditions to the strength of interaction between antibody and analyte. ..
  19. BUILDING PREVENTIVE GROUP NORMS IN URBAN MIDDLE SCHOOLS
    Jean Schensul; Fiscal Year: 2003
    ..Years 4 and 5 will be utilized to collect the final outcome assessment data, to analyze and triangulate data and to finalize curriculum and publications. ..
  20. EFFECTS OF PARTNER VIOLENCE VICTIMIZATION IN DRUG USE
    Merrill Singer; Fiscal Year: 2002
    ....
  21. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  22. Hamster Model for AIDS Lymphomas
    JANET BUTEL; Fiscal Year: 2003
    ..In addition, this project may provide new insights into lymphomagenesis in general and may lead to the development of new diagnostic and therapeutic approaches to this malignancy. ..
  23. SYRINGE ACCESS AND HIV RISK
    Merrill Singer; Fiscal Year: 2002
    ..g., high or low availability of sterile syringes) and actual risk factors (e.g., frequency of infected syringes in circulation). ..
  24. AIDS RISK IN OLDER URBAN ADULT SENIOR HOUSING RESIDENTS
    Jean Schensul; Fiscal Year: 2002
    ..abstract_text> ..
  25. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  26. DETERMINING/UNDERSTANDING BARRIERS TO ADULT IMMUNIZATION
    Richard Zimmerman; Fiscal Year: 2001
    ..This project will furnish relevant, up-to-date to enhance policy planning, practice management and medical education. ..
  27. Immune Mechanisms and HIV Disease Pathogenesis
    Michael Lederman; Fiscal Year: 2004
    ..The proposal's specific request is for support to increase participation in the Conference by female and/or minority researchers and students. ..
  28. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  29. MDMA and STD/HIV Risk among Hidden Networks of Ecstasy-using Young Adults
    Jean Schensul; Fiscal Year: 2009
    ....
  30. PATHWAYS TO HIGH RISK DRUG ABUSE AMONG URBAN YOUTH
    Jean Schensul; Fiscal Year: 2001
    ....
  31. The Medical Consequences of Different Types of Heroin
    Daniel Ciccarone; Fiscal Year: 2008
    ..e., soft tissue infection, HIV and heroin related overdose. [unreadable] [unreadable] [unreadable] [unreadable]..
  32. ENHANCING MUCOSAL IMMUNE RESPONSES BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 2005
    ..The availability of microencapsulated virus provides a unique opportunity to understand the relationship between APC and protective mucosal immune responses. ..
  33. MINORITY YOUTH ACTION RESEARCH TRAINING INSTITUTE
    Jean Schensul; Fiscal Year: 2002
    ....
  34. 2007 Case CFAR Annual Spring Conference
    Michael Lederman; Fiscal Year: 2007
    ..The Case CFAR is proactive in its efforts to ensure inclusion of minority and female researchers in[unreadable] all aspects of Conference planning and attendance. ..
  35. CONFERENCE ON HIV PATHOGENESIS
    Michael Lederman; Fiscal Year: 2005
    ....
  36. Alcohol, Risky Behavior and HIV Prevention in Mumbai, India
    Jean Schensul; Fiscal Year: 2007
    ....
  37. Statistical Methods to Study the Epidemiology of HIV & Other Disease
    Nicholas P Jewell; Fiscal Year: 2010
    ....
  38. Statistical Techniques for Complex Environmental Epidemiological Studies
    Nicholas P Jewell; Fiscal Year: 2010
    ....
  39. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  40. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  41. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  42. Mechanism of in-vitro aging
    LYSLE LEWIS; Fiscal Year: 2007
    ..The proposed research will enhance our understanding of events that occur as a consequence of shortened chromosomes and factors that affect the rate of shortening. [unreadable] [unreadable] [unreadable]..
  43. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  44. Reduce Transmission Risks & Improve HCV Treatment Access
    Steffanie Strathdee; Fiscal Year: 2004
    ....
  45. BALTIMORE NEEDLE EXCHANGE PROGRAM EVALUATION
    Steffanie Strathdee; Fiscal Year: 2004
    ..In meeting the above specific aims, the proposed study will have an important impact on policies surrounding NEP in the United States and elsewhere. ..