Genomes and Genes
Summary: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Publications272 found, 100 shown here
- Neighborhood-based differences in physical activity: an environment scale evaluationBrian E Saelens
Division of Psychology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 3015, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Am J Public Health 93:1552-8. 2003..This study evaluated a neighborhood environment survey and compared the physical activity and weight status of the residents in 2 neighborhoods...
- Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trialsJohn J Aponte
Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
Lancet 374:1533-42. 2009Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.
- Built environment correlates of walking: a reviewBrian E Saelens
Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA, USA
Med Sci Sports Exerc 40:S550-66. 2008..This article reviews evidence on the built environment correlates with walking...
- Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort studyHenry Krum
Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia
Lancet 373:1275-81. 2009..sympathetic denervation in patients with resistant hypertension (ie, systolic blood pressure >/=160 mm Hg on three or more antihypertensive medications, including a diuretic) to assess safety and blood-pressure reduction effectiveness.
- Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancerCharles L Vogel
University of Miami School of Medicine, Comprehensive Cancer Research Group Inc, and Columbia Cancer Research Network of Florida, Miami, FL, USA
J Clin Oncol 20:719-26. 2002To evaluate the efficacy and safety of first-line, single-agent trastuzumab in women with HER2-overexpressing metastatic breast cancer.
- Variation in the safety of induced pluripotent stem cell linesKyoko Miura
Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
Nat Biotechnol 27:743-5. 2009..In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells...
- Dietary flavonoids: bioavailability, metabolic effects, and safetyJulie A Ross
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Annu Rev Nutr 22:19-34. 2002..Because there are many biological activities attributed to the flavonoids, some of which could be beneficial or detrimental depending on specific circumstances, further studies in both the laboratory and with populations are warranted...
- Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disordersMaria Ester Bernardo
Department of Pediatric Hematology Oncology, IRCCS Bambino Gesù Children s Hospital, Rome, Italy
Ann N Y Acad Sci 1266:107-17. 2012..Experimental studies in animal models and phase I/II clinical trials on the use of MSCs for the treatment of IBDs and other inflammatory/degenerative conditions are reviewed...
- Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trialDipika Sur
National Institute of Cholera and Enteric Diseases, Kolkata, India
Lancet 374:1694-702. 2009..To expand the use of this vaccine, it was modified to comply with WHO standards. We assessed the efficacy and safety of this modified vaccine in a population with endemic cholera.
- Relationship between the physical environment and physical activity in older adults: a systematic reviewJelle Van Cauwenberg
Department of Human Biometry and Biomechanics, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
Health Place 17:458-69. 2011..More studies in different contexts utilizing longitudinal designs, standardized, reliable and validated PA and environmental measurements and investigating possible moderating effects are definitely warranted...
- Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine in women aged 24-45 years: a randomised, double-blind trialNubia Munoz
National Institute of Cancer, Bogota, Colombia
Lancet 373:1949-57. 2009..We tested the safety, immunogenicity, and efficacy of the quadrivalent HPV (types 6, 11, 16, 18) L1 virus-like-particle vaccine in ..
- Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexateM Schiff
Denver Arthritis Clinic, 200 Spruce Street 100, Denver, CO 80230, USA
Ann Rheum Dis 67:1096-103. 2008This double-blind trial evaluated the efficacy and safety of abatacept or infliximab vs placebo...
- A smartphone-based driver safety monitoring system using data fusionBoon Giin Lee
Department of Electronic Engineering, Pukyong National University, Busan 608 737, Korea
Sensors (Basel) 12:17536-52. 2012This paper proposes a method for monitoring driver safety levels using a data fusion approach based on several discrete data types: eye features, bio-signal variation, in-vehicle temperature, and vehicle speed...
- Nanomaterials in the construction industry: a review of their applications and environmental health and safety considerationsJaesang Lee
Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
ACS Nano 4:3580-90. 2010....
- Evolution, safety, and highly pathogenic influenza virusesMarc Lipsitch
Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Science 336:1529-31. 2012..Thus, we propose that future experiments with virulent pathogens whose accidental or deliberate release could lead to extensive spread in human populations should be limited by explicit risk-benefit considerations...
- Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent formClaudia M Witt
Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
Forsch Komplementmed 16:91-7. 2009To evaluate the safety of acupuncture in a large number of patients receiving conventional health care and, based on these results, to develop a new medical consent form for acupuncture.
- Neighborhood disorder, perceived safety, and readiness to encourage use of local playgroundsRebecca Miles
Department of Urban and Regional Planning, Florida State University, Tallahassee, Florida 32306 2280, USA
Am J Prev Med 34:275-81. 2008..the neighborhood physical environment and adults' readiness to encourage children's use of local playgrounds, and the extent to which perceived safety acts as a mediator, can inform efforts to increase children's physical activity.
- Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug developmentW S Redfern
Safety Assessment UK, AstraZeneca R and D Alderley Park, Macclesfield, Cheshire, UK
Cardiovasc Res 58:32-45. 2003..To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use...
- Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South AfricaTony Hawkridge
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
J Infect Dis 198:544-52. 2008..One leading booster vaccine, MVA85A (where "MVA" denotes "modified vaccinia virus Ankara"), has shown promising safety and immunogenicity in human trials performed in the United Kingdom...
- Patient involvement in patient safety: what factors influence patient participation and engagement?Rachel E Davis
Clinical Safety Research Unit, Department of Bio Surgery and Surgical Technology, QEQM, St Mary s Hospital, London, UK
Health Expect 10:259-67. 2007Patients can play an important role in improving patient safety by becoming actively involved in their health care. However, there is a paucity of empirical data on the extent to which patients take on such a role...
- The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trialWilliam A Marston
University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7212, USA
Diabetes Care 26:1701-5. 2003..To determine if a human fibroblast-derived dermal substitute could promote the healing of diabetic foot ulcers...
- Perceived environmental correlates of physical activity for leisure and transportation in Curitiba, BrazilDiana C Parra
Prevention Research Center in St Louis, George Warren Brown School of Social Work, Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA
Prev Med 52:234-8. 2011..Physical activity (PA) has consistently been associated with perceived environmental characteristics...
- Efficacy and safety of automatic remote monitoring for implantable cardioverter-defibrillator follow-up: the Lumos-T Safely Reduces Routine Office Device Follow-up (TRUST) trialNiraj Varma
Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Circulation 122:325-32. 2010....
- The built environment, neighborhood crime and constrained physical activity: an exploration of inconsistent findingsSarah Foster
School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
Prev Med 47:241-51. 2008Personal safety is commonly cited in qualitative research as a barrier to local walking, yet the relationship between safety and constrained physical activity has received mixed support in quantitative studies...
- Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safetyShawna L Lemke
Monsanto Company, St Louis, MO 63167, USA
Am J Clin Nutr 92:766-75. 2010..The benefits of omega-3 (n-3) long-chain polyunsaturated fatty acids to heart health are well established. Stearidonic acid (SDA, 18:4n-3) may contribute to these benefits...
- A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 yearsRichard D Antrobus
The Jenner Institute, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e48322. 2012..We assessed the safety and immunogenicity of MVA-NP+M1, a viral-vectored influenza vaccine designed to boost memory T cell responses, in ..
- Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancerMark A Socinski
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
J Thorac Oncol 5:354-60. 2010....
- Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect levelR Vieth
Mount Sinai Hospital, Toronto, Ontario, Canada
Am J Clin Nutr 73:288-94. 2001..The Food and Nutrition Board of the National Academy of Sciences states that 95 microg vitamin D/d is the lowest observed adverse effect level (LOAEL)...
- Benefits of Water Safety Plans: microbiology, compliance, and public healthMaría J Gunnarsdóttir
Faculty of Civil and Environmental Engineering, University of Iceland, Hjardarhaga 2 6, 107 Reykjavik, Iceland
Environ Sci Technol 46:7782-9. 2012The Water Safety Plan (WSP) methodology, which aims to enhance safety of drinking water supplies, has been recommended by the World Health Organization since 2004. WSPs are now used worldwide and are legally required in several countries...
- Perceived crime and traffic safety is related to physical activity among adults in NigeriaAdewale L Oyeyemi
Department of Physiotherapy, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria
BMC Public Health 12:294. 2012Neighborhood safety is inconsistently related to physical activity, but is seldom studied in developing countries. This study examined associations between perceived neighborhood safety and physical activity among Nigerian adults.
- Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adultsFrances H Priddy
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Clin Infect Dis 46:1769-81. 2008The safety and immunogenicity of the MRK adenovirus type 5 human immunodeficiency virus type 1 clade B gag/pol/nef vaccine, a replication-incompetent adenovirus type 5-vectored vaccine designed to elicit cell-mediated immunity against ..
- Physician attitudes towards pharmacological cognitive enhancement: safety concerns are paramountOpeyemi C Banjo
National Core for Neuroethics, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 5:e14322. 2010..as to the reasons they answered as they did, the most prominent concerns physicians expressed were issues of safety that were not offset by the benefit afforded the individual, even in the face of explicit safety claims...
- The relation between neighborhood built environment and walking activity among older adultsCorey L Nagel
School of Nursing, Oregon Health and Science University, Portland, OR, USA
Am J Epidemiol 168:461-8. 2008..These findings suggest that built environment may not play a significant role in whether older adults walk, but, among those who do walk, it is associated with increased levels of activity...
- Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studiesAjay J Kirtane
The Cardiovascular Research Foundation, Columbia University Medical Center, 111 E 59th Street, New York, NY 10022, USA
Circulation 119:3198-206. 2009The safety and efficacy of drug-eluting stents (DES) among more generalized "real-world" patients than those enrolled in pivotal randomized controlled trials (RCTs) are controversial...
- Safety and efficacy of adjunctive balloon remodeling during endovascular treatment of intracranial aneurysms: a literature reviewM Shapiro
Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 29:1777-81. 2008..Nevertheless, there exists concern that adjunctive use of balloon assistance may lead to increased adverse events during aneurysm coiling...
- Long-term safety of loteprednol etabonate 0.2% in the treatment of seasonal and perennial allergic conjunctivitisHaroon Ilyas
Department of Ophthalmology, University of South Florida College of Medicine, Tampa, FL 33613, USA
Eye Contact Lens 30:10-3. 2004To determine the long-term safety of the topical steroid, loteprednol etabonate 0.2%, in the treatment of seasonal and perennial allergic conjunctivitis.
- Fitness of human enteric pathogens on plants and implications for food safetyMaria T Brandl
Produce Safety and Microbiology Research Unit, Agricultural Research Services, U S Department of Agriculture, Albany, California 94710, USA
Annu Rev Phytopathol 44:367-92. 2006....
- Safety issues and prospects for future generations of PPAR modulatorsAnne Rubenstrunk
GENFIT, F 59006 Loos, France
Biochim Biophys Acta 1771:1065-81. 2007..However, despite the proven benefits of targeting PPARs, safety concerns have recently led to late stage development failures of various PPAR agonists including novel specific ..
- Safety in numbers: more walkers and bicyclists, safer walking and bicyclingP L Jacobsen
Public Health Consultant, 4730 Monterey Way, Sacramento, CA 95822, USA
Inj Prev 9:205-9. 2003..However, three published analyses of collision rates at specific intersections found a non-linear relationship, such that collisions rates declined with increases in the numbers of people walking or bicycling...
- Teamwork and patient safety in dynamic domains of healthcare: a review of the literatureT Manser
ETH Zurich, Center for Organizational and Occupational Sciences, Zurich, Switzerland
Acta Anaesthesiol Scand 53:143-51. 2009..research on teamwork in highly dynamic domains of healthcare such as operating rooms, intensive care, emergency medicine, or trauma and resuscitation teams with a focus on aspects relevant to the quality and safety of patient care.
- Exploring associations between physical activity and perceived and objective measures of the built environmentAileen P McGinn
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Urban Health 84:162-84. 2007....
- Seeking safety and empathy: adolescent health seeking behavior during pregnancy and early motherhood in central UgandaLynn Atuyambe
Department of Community Health and Behavioral Sciences, Makerere University School of Public Health, Kampala, Uganda
J Adolesc 32:781-96. 2009..This will in long-term have an impact on the reduction of morbidity and mortality among adolescent mothers and their newborns...
- Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterialsFernando Torres Andón
Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Acc Chem Res 46:733-42. 2013..An improved understanding of the complexities of the nanomaterial-induced perturbation of different cell death pathways may allow for a better prediction of the consequences of human exposure...
- Patient involvement in patient safety: Protocol for developing an intervention using patient reports of organisational safety and patient incident reportingJane K Ward
Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Duckworth Lane, Bradford, BD9 6RJ, UK
BMC Health Serv Res 11:130. 2011Patients have the potential to provide a rich source of information on both organisational aspects of safety and patient safety incidents...
- Aesthetic amenities and safety hazards associated with walking and bicycling for transportation in New York CityGina S Lovasi
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA
Ann Behav Med 45:S76-85. 2013..One strategy to address health problems related to insufficient physical activity is to examine modifiable neighborhood characteristics associated with active transportation...
- Meta-analysis of the efficacy and safety of adalimumab, etanercept, and infliximab for the treatment of rheumatoid arthritisAstrid Wiens
Pharmacy Practice Research Group, Pharmacy Department, Federal University of Parana, Curitiba, Parana, Brazil
Pharmacotherapy 30:339-53. 2010To evaluate the efficacy and safety of using the anti-tumor necrosis factor-alpha (anti-TNF-alpha) drugs adalimumab, etanercept, and infliximab for the treatment of rheumatoid arthritis.
- Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributesTravis T Wager
558 Eastern Point Road, Groton, CT, USA
ACS Chem Neurosci 1:420-34. 2010..distribution, metabolism, and elimination) attributes, primary pharmacology binding efficiencies, and in vitro safety data for these two sets of compounds...
- Safety of divalproex sodium in migraine prophylaxis: an open-label, long-term study. Long-term Safety of Depakote in Headache Prophylaxis Study GroupS D Silberstein
Jefferson Headache Center, Thomas Jefferson University, 111 South 11th Street, Suite 81309, Philadelphia, PA 19107, USA
Headache 39:633-43. 1999..of long-term divalproex therapy for epilepsy is well established, but little is known about the tolerability or safety of divalproex in long-term migraine prophylaxis...
- Students' perceptions of patient safety during the transition from undergraduate to postgraduate training: an activity theory analysisJeantine M de Feijter
Department of Educational Development and Research, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Adv Health Sci Educ Theory Pract 16:347-58. 2011..medical error can cause harm to patients has raised the attention of the health care community towards patient safety and influenced how and what medical students learn about it...
- Smart roadside system for driver assistance and safety warnings: framework and applicationsJeong Ah Jang
Vehicle Ship IT Convergence Research Department, ETRI, Electronics and Telecommunications Research Institute, 161 Gajeong dong, Yuseong Gu, Daejeon 305 350, Korea
Sensors (Basel) 11:7420-36. 2011..This paper introduces a smart roadside system that utilizes various sensors for driver assistance and traffic safety warnings...
- Safety criteria for transcranial direct current stimulation (tDCS) in humansMichael A Nitsche
Clin Neurophysiol 114:2220-2; author reply 2222-3. 2003
- Physical activity among elderly people in a city population: the influence of neighbourhood level violence and self perceived safetyFredrik N Piro
Institute of General Practice and Community Medicine, PO Box 1130 Blindern, N 0317 Oslo, Norway
J Epidemiol Community Health 60:626-32. 2006..To study the associations between neighbourhood level violence/fear of violence and physical activity among elderly people, accounting for somatic health...
- Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomised trialMarian J E Mourits
Department of Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands
Lancet Oncol 11:763-71. 2010..This study investigated the complication rate of TLH versus TAH in women with early-stage endometrial cancer...
- Critical factors for active transportation to school among low-income and minority students. Evidence from the 2001 National Household Travel SurveyNoreen C McDonald
Department of City and Regional Planning, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3140, USA
Am J Prev Med 34:341-4. 2008..g., Safe Routes to School and the CDC's KidsWalk programs). However, little research has looked at differences in behavior across racial/ethnic and income groups...
- Testing metal-oxide nanomaterials for human safetyRobert Landsiedel
BASF SE 67056 Ludwigshafen, Germany
Adv Mater 22:2601-27. 2010..Enhanced understanding of biophysical properties and cellular effects results in improved testing strategies and enables the selection and production of safe materials...
- Immunogenicity, reactogenicity, and safety of a seven-valent pneumococcal conjugate vaccine (PCV7) concurrently administered with a fully liquid DTPa-IPV-HBV-Hib combination vaccine in healthy infantsC Olivier
Hôpital L Mourier, Colombes, France
Vaccine 26:3142-52. 2008To evaluate the immunogenicity, safety and reactogenicity of a seven-valent pneumococcal conjugate vaccine (PCV7) when given concomitantly with a fully liquid DTaP-IPV-HBV-Hib combination vaccine.
- A study of the lagged relationships among safety climate, safety motivation, safety behavior, and accidents at the individual and group levelsAndrew Neal
ARC Key Centre for Human Factors and Applied Cognitive Psychology, School of Psychology, University of Queensland, Brisbane, QLD, Australia
J Appl Psychol 91:946-53. 2006The authors measured perceptions of safety climate, motivation, and behavior at 2 time points and linked them to prior and subsequent levels of accidents over a 5-year period...
- Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: a systematic reviewL Varela-Lema
Galician Agency for Health Technology Assessment, Department of Health, Galician Regional Authority, University of Santiago de Compostela, Santiago de Compostela, Spain
Eur Respir J 33:1156-64. 2009The aim of the present systematic review was to assess the effectiveness and safety of real time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with suspected or known bronchopulmonary carcinoma, ..
- A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogsJean Steffan
Novartis Animal Health, Basel, Switzerland
Vet Dermatol 17:3-16. 2006..Treatment duration varied from 2 weeks to 6 months. For safety analysis, data were available from 660 dogs...
- Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetesMarkolf Hanefeld
Zentrum für Klinische Studien, GWT, Technische Universitat Dresden, Dresden, Germany
Cardiovasc Diabetol 6:20. 2007..The efficacy, safety and tolerability of the alpha-glucosidase inhibitor acarbose have been well-established in a wide range of patient ..
- Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitisJean Steffan
Novartis Animal Health, CH4002 Basel, Switzerland
J Am Vet Med Assoc 226:1855-63. 2005To determine efficacy and safety of cyclosporine in the treatment of atopic dermatitis among dogs in North America.
- Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomasHoward A Burris
The Sarah Cannon Research Institute, 250 25th Avenue N, Suite 110, Nashville, TN 37203, USA
J Clin Oncol 23:5305-13. 2005This study (EGF10004) assessed the safety/tolerability, pharmacokinetics, and clinical activity of daily oral dosing with lapatinib (GW572016) in patients with ErbB1-expressing and/or ErbB2-overexpressing advanced-stage refractory solid ..
- Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetesKenji Nonaka
Banyu Pharmaceutical Co Ltd, Tokyo, Japan
Diabetes Res Clin Pract 79:291-8. 2008..01) different relative to the placebo group (-0.7 kg). In this study, once-daily sitagliptin 100mg for 12 weeks improved fasting and postprandial glycemic control and was generally well tolerated in Japanese patients with type 2 diabetes...
- Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic imagesD W Kitzman
Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
Am J Cardiol 86:669-74. 2000..This study examines the safety and efficacy of perflutren, a novel ultrasound contrast agent, for LV cavity opacification and endocardial border ..
- Irradiation as a safety procedure in tissue bankingAnna Dziedzic-Goclawska
National Centre of Tissue and Cell Banking, ul Chalubinskiego 5, 02 004, Warsaw, Poland
Cell Tissue Bank 6:201-19. 2005....
- Microbiological safety of drinking waterU Szewzyk
Technical University Berlin, Microbial Ecology Group, Secr OE 5, Berlin, 10587 Germany
Annu Rev Microbiol 54:81-127. 2000..Results of epidemiological studies together with ecological data are the basis for effective resource protection, water treatment, and risk assessment...
- Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteinsKathryn H Schmitz
Division of Clinical Epidemiology University of Pennsylvania 423 Guardian Drive, 9th Floor Blockley Drive, Philadelphia, PA 19072 215 898 0901
Cancer Epidemiol Biomarkers Prev 14:1672-80. 2005This randomized controlled trial assessed the safety and effects of twice-weekly weight training among recent breast cancer survivors. Outcomes included body size and biomarkers hypothesized to link exercise and breast cancer risk.
- Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspectsMichael A Nitsche
Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gotingen, Germany
Suppl Clin Neurophysiol 56:255-76. 2003
- Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging studyH Buller
Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
J Thromb Haemost 6:1313-8. 2008..We conducted a dose-ranging study in patients with deep vein thrombosis...
- Hymenoptera ultra-rush venom immunotherapy (210 min): a safety study and risk factorsJ Birnbaum
UPRES EA 3287, Service de pneumo allergologie, Hopital Sainte Marguerite, Marseille, France
Clin Exp Allergy 33:58-64. 2003....
- A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressedChristiane S Hartog
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
Anesth Analg 112:635-45. 2011..There are safety concerns with regard to coagulopathy, renal failure, pruritus, tissue storage, and mortality...
- Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeksStanley B Cohen
Radiant Research, Dallas, Texas 75235, USA
Arthritis Rheum 54:2793-806. 2006To determine the efficacy and safety of treatment with rituximab plus methotrexate (MTX) in patients with active rheumatoid arthritis (RA) who had an inadequate response to anti-tumor necrosis factor (anti-TNF) therapies and to explore ..
- Using FDA reports to inform a classification for health information technology safety problemsFarah Magrabi
Centre for Health Informatics, Australian Institute for Health Innovation, University of New South Wales, Sydney, Australia
J Am Med Inform Assoc 19:45-53. 2012..To expand an emerging classification for problems with health information technology (HIT) using reports submitted to the US Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database...
- Active commuting to school: Associations with environment and parental concernsJacqueline Kerr
Department of Psychology, San Diego State University, San Diego, CA 92103, USA
Med Sci Sports Exerc 38:787-94. 2006....
- Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III studyDavid A Bluemke
Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Radiology 237:89-98. 2005To assess prospectively the efficacy and safety of postcontrast magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) compared with that of precontrast MR imaging in patients who ..
- Towards a definition of inorganic nanoparticles from an environmental, health and safety perspectiveMelanie Auffan
Center for the Environmental Implications of NanoTechnology CEINT, Duke University, 121 Hudson Hall, Durham, North Carolina 27707, USA
Nat Nanotechnol 4:634-41. 2009..in any definition of nanoparticles when making decisions about their regulation for environmental, health and safety reasons...
- Neighborhood environmental factors correlated with walking near home: Using SPACESTerri J Pikora
School of Population Health, The University of Western Australia, Perth, Western Australia, Australia
Med Sci Sports Exerc 38:708-14. 2006..We examined correlations between physical environmental factors and self-reported walking for recreation and transport near home...
- Plant-produced idiotype vaccines for the treatment of non-Hodgkin's lymphoma: safety and immunogenicity in a phase I clinical studyA A McCormick
Large Scale Biology Corporation, 3333 Vaca Valley Parkway, Vacaville, CA 95688, USA
Proc Natl Acad Sci U S A 105:10131-6. 2008..follicular B cell lymphoma and the results of administering these vaccines to lymphoma patients in a phase I safety and immunogenicity clinical trial...
- Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West AfricaRoger H Brookes
Bacterial Diseases Programme, Tuberculosis Division, Medical Research Council Laboratories, Fajara, Banjul, The Gambia
PLoS ONE 3:e2921. 2008..We assessed the safety and immunogenicity of this new vaccine in West African volunteers.
- Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primatesIgor S Lukashevich
Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
Vaccine 26:5246-54. 2008..that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.
- Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back painBernd Lange
Global Development, Grunenthal GmbH, D 52078 Aachen, Germany
Adv Ther 27:381-99. 2010....
- From fear to safety and back: reversal of fear in the human brainDaniela Schiller
Psychology Department, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 28:11517-25. 2008..To date, research on fear modulation has focused mainly on the shift from fear to safety by using paradigms such as extinction, resulting in a reduction of fear...
- Safety of influenza vaccination during pregnancyPranita D Tamma
Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Obstet Gynecol 201:547-52. 2009..In this article, we review the evidentiary basis for the recommendation of vaccination of all women who will be pregnant during the influenza season and safety data of influenza vaccination during pregnancy.
- A phase II, open-label, randomized study to assess the efficacy and safety of AZD6244 (ARRY-142886) versus pemetrexed in patients with non-small cell lung cancer who have failed one or two prior chemotherapeutic regimensJohn D Hainsworth
Sarah Cannon Research Institute, Nashville, TN 37203, USA
J Thorac Oncol 5:1630-6. 2010AZD6244 (ARRY-142886) is a potent, selective MEK inhibitor. This study aimed to evaluate the efficacy and safety of AZD6244 versus pemetrexed as second- or third-line treatment in patients with advanced non-small cell lung cancer (NSCLC).
- Antidepressants and suicide risk: how did specific information in FDA safety warnings affect treatment patterns?Susan H Busch
Yale School of Public Health, P O Box 208034, Suite 300, New Haven, CT 06520 8034, USA
Psychiatr Serv 61:11-6. 2010From June 2003 through October 2004, the U.S. Food and Drug Administration (FDA) released five safety warnings related to antidepressant use and the increased risk of suicidality for children...
- Feeder layer- and animal product-free culture of neonatal foreskin keratinocytes: improved performance, usability, quality and safetyPeter De Corte
Skin and Keratinocyte Bank, Laboratory for Molecular and Cellular Technology, Burn Wound Centre, Queen Astrid Military Hospital, Bruynstraat 1, 1120 Brussels, Belgium
Cell Tissue Bank 13:175-89. 2012..These optimisations have significantly increased the performance, usability, quality and safety of our allografts. This paper describes, in detail, our current cryopreserved allograft production process.
- Combined oral prolonged-release oxycodone and naloxone in opioid-induced bowel dysfunction: review of efficacy and safety data in the treatment of patients experiencing chronic painKatri Elina Clemens
University of Bonn, Malteser Hospital Bonn Rhein Sieg, Centre for Palliative Medicine, Department of Science and Research, Von Hompesch Str 1, D 53123 Bonn, Germany
Expert Opin Pharmacother 11:297-310. 2010..The combination of the strong opioid oxycodone and the opioid antagonist naloxone has the potential to prevent opioid-induced bowel dysfunction (OIBD) while maintaining analgesic efficacy...
- Efficacy and safety of treatment with incobotulinum toxin A (botulinum neurotoxin type A free from complexing proteins; NT 201) in post-stroke upper limb spasticityPetr Kanovsky
Department of Neurology, Palacky University Medical School University Hospital, IP Pavlova 6, CZ 775 20 Olomouc, Czech Republic
J Rehabil Med 43:486-92. 2011To investigate the efficacy and safety of repeated treatment with incobotulinum toxin A (botulinum neurotoxin type A free from complexing proteins; NT 201) in post-stroke upper limb spasticity.
- The safety and efficacy of travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solutionHoward S Barnebey
University of Washington, Ophthalmology, Specialty Eye Care Center, Seattle, 98004, USA
Am J Ophthalmol 140:1-7. 2005To compare the safety and intraocular pressure (IOP)-lowering efficacy of travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solution (Trav/Tim) to its components travoprost 0...
- Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Marja Hedman
A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
Circulation 107:2677-83. 2003..However, only limited data are available about local VEGF gene transfer given during angioplasty (PTCA) and stenting...
- Neighborhood safety, socioeconomic status, and physical activity in older adultsReginald D Tucker-Seeley
Department of Society, Human Development and Health, Harvard School of Public Health, Boston, Massachusetts, USA
Am J Prev Med 37:207-13. 2009..Yet, the moderating influence of various measures of SES on the association between perceived neighborhood safety and leisure-time physical activity (LTPA) among older adults remains unknown.
- Assessment of postlicensure safety of rotavirus vaccines, with emphasis on intussusceptionJulie E Bines
Department of Paediatrics, University of Melbourne, Melbourne, Australia
J Infect Dis 200:S282-90. 2009..In response to a recommendation of the World Health Organization Global Advisory Committee for Vaccine Safety, a standardized approach to the postmarketing surveillance of rotavirus vaccine safety has been developed...
- Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 studyMichael Nauck
Diabeteszentrum Bad Lauterberg, Harz, Germany
Diabetes Care 32:84-90. 2009The efficacy and safety of adding liraglutide (a glucagon-like peptide-1 receptor agonist) to metformin were compared with addition of placebo or glimepiride to metformin in subjects previously treated with oral antidiabetes (OAD) therapy.
- Physical activity levels according to physical and social environmental factors in a sample of adults living in South BrazilTales C Amorim
Post Graduate Program in Epidemiology, Federal University of Pelotas, Brazil
J Phys Act Health 7:S204-12. 2010..To evaluate the association between the physical and social environment and physical activity (leisure-time and transport-related) in a population-based sample of adults...
- Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy: a report by the American Academy of OphthalmologyAlan Sugar
Ophthalmic Technology Assessment Committee 2000 2001 Refractive Surgery Panel
Ophthalmology 109:175-87. 2002This document describes laser in situ keratomileusis (LASIK) for myopia and astigmatism and examines the evidence to answer key questions about the efficacy and safety of the procedure.
- Safety and tolerability of frovatriptan in the acute treatment of migraine and prevention of menstrual migraine: Results of a new analysis of data from five previously published studiesE Anne MacGregor
The City of London Migraine Clinic, London, United Kingdom
Gend Med 7:88-108. 2010..Triptans are a recommended first-line treatment for moderate to severe migraine...
- Playing it safe: the influence of neighbourhood safety on children's physical activity. A reviewAlison Carver
Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Vic, Australia
Health Place 14:217-27. 2008..Many studies have identified lack of neighbourhood safety as a potential barrier to children's physical activity...
- Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trialD D Rhoads
Department of Psychiatry, University of Minnesota, Minneapolis, USA
J Wound Care 18:237-8, 240-3. 2009This phase 1 trial set out to examine the safety of a bacteriophage-based preparation for difficult-to-treat wounds.
- Does simulation improve patient safety? Self-efficacy, competence, operational performance, and patient safetyAkira Nishisaki
Division of Critical Care, Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Anesthesiol Clin 25:225-36. 2007Simulation training is an essential educational strategy for health care systems to improve patient safety. The strength of simulation training is its suitability for multidisciplinary team training...
- A strategy for describing the biosphere at candidate sites for repositories of nuclear waste: linking ecosystem and landscape modelingTobias Lindborg
Swedish Nuclear Fuel and Waste Management Co, Stockholm
Ambio 35:418-24. 2006..paper, we present a strategy to integrate site-specific ecosystem data into spatially explicit models needed for safety assessment studies and the environmental impact assessment...
- Ionophores: their use as ruminant growth promotants and impact on food safetyT R Callaway
Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center, 2881 F and B Rd, Agricultural Research Service, USDA, College Station, TX 77845, USA
Curr Issues Intest Microbiol 4:43-51. 2003..Therefore it appears that ionophores will continue to play a significant role in improving the efficiency of animal production in the future...
- Public Health Model to Promote Safe Elderly DrivingSherrilene Classen; Fiscal Year: 2006DESCRIPTION (provided by applicant): Older driver safety is a complex phenomenon that extends beyond the person level to multiple systems (e.g., regulatory, policy-making, societal and health care)...
- Activity Space Environments, Behaviors, and Body Weight Status in Urban AdultsShannon Zenk; Fiscal Year: 2009....
- Pharmacotherapy for Minor DepressionRobert Howland; Fiscal Year: 2004..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
- Inflammatory and Infectious Burden and Risk of StrokeMitchell Elkind; Fiscal Year: 2008..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
- Understanding Change in Physical Activity PostpartumKELLY EVENSON; Fiscal Year: 2009..This proposal directly addresses the need to better understand multi-level factors involved in physical activity behavior change, RFA #CA-04-009 "Mechanisms of Physical Activity Behavior Change". ..
- Spousal communication and cancer prevention behaviorKELLY EVENSON; Fiscal Year: 2006..The long-term goal of this research is to develop better interventions which help prevent cancer, and other chronic health conditions, by involving spouses in preventive behavior change programs. [unreadable] [unreadable]..
- BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUNDDouglas Miller; Fiscal Year: 2009..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
- Alcohol in Aviation and Motor CarriersGuohua Li; Fiscal Year: 2010..are to better understand the role of alcohol in aviation and motor carrier accidents and to improve transportation safety. The specific aims are: (1) to determine the point prevalence rates of alcohol violations among safety-sensitive ..
- Inflammation and Infection as Risk Factors in StrokeMitchell Elkind; Fiscal Year: 2006..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
- Proactive Risk Assessment of Primary Care of the ElderlyBen Tzion Karsh; Fiscal Year: 2007..This complexity makes primary care likely to have a high prevalence of safety hazards...
- The Value of CPOE in Pediatric Inpatient Units and Its Impact on Safety and WorkBen Tzion Karsh; Fiscal Year: 2008..available CPOE systems have realized benefits; with some centers reporting potentially worsened patient safety. One potentially significant aspect of CPOE implementation and use, which may ultimately determine the true ..
- ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPYDouglas Miller; Fiscal Year: 2003..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
- Bar Coding Technology and Patient and Employee SafetyBen Tzion Karsh; Fiscal Year: 2006..human factors engineering systems principles represents a significant step in health care technology and patient safety research for at least four reasons...
- BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUNDDouglas Miller; Fiscal Year: 2001..contrast agents (DUCA), which consist of suspensions of stabilized gas-bodies, presents the most pressing safety issues in medical ultrasound...
- Levels of Inflammatory Markers in Treatment of StrokeMitchell Elkind; Fiscal Year: 2008..abstract_text> ..
- Violence Against Home Health and Hospice WorkersCarri Casteel; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Atherogenic Effects of Ambient PM In Susceptible AnimalsAndre Nel; Fiscal Year: 2007..These mice will be exposed to CAPs as discussed in Aims 1 and 2, and select endpoints used to demonstrate the effect on atherosclerotic inflammation and apoptosis. ..
- Psychiatric Emergency Room Care: Staff PerspectivesAlisa Lincoln; Fiscal Year: 2007..abstract_text> ..
- Moderating Social Norms Interventions: Field ExperimentMark Johnson; Fiscal Year: 2009..This research will help identify factors that might improve the efficacy of social norms interventions. ..
- Bloodborne Pathogen Risk in Home Healthcare WorkersRobyn Gershon; Fiscal Year: 2007..c) organizational variables (availability and adequacy of resources, including the availability of safety devices and other control measures; safety climate, safety training, medical surveillance programs, etc...
- Predictors of Adolescent Girls Physical ActivityKIRSTEN DAVISON; Fiscal Year: 2007..Such information is essential to designing effective prevention programs that promote recommended levels of physical activity during adolescence. [unreadable] [unreadable]..
- African American Men Prostate & Colorectal Cancer BeliefThomas Arcury; Fiscal Year: 2007..A preliminary framework of the intervention strategy for this R01 application will be developed and evaluated as part of this project. [unreadable] [unreadable]..
- Telomere-Mediated Protective Responses in SkinBarbara Gilchrest; Fiscal Year: 2007..The studies will also explore the possible therapeutic potential of T-oligos that comparably induce these responses in the absence of actual DNA damage or telomere disruption. ..
- VANDERBILT ADULT AIDS CLINICAL TRIALS UNITDavid Haas; Fiscal Year: 2006..The proposed ACTU will not only enroll patients into ACTG clinical trials, but will provide the ACTG the ability to address important questions concerning AIDS treatment and pathogenesis. ..
- DyNADS: A Dynamic Network Analysis Decision Support Tool for Nurse ManagersJoyce A Verran; Fiscal Year: 2010..unit's current performance, and (b) predict the impact of potential unit innovations to improve targeted safety and quality outcomes...
- Ethnic Variation in CAM Use and Health Self Management among Rural Older AdultsThomas Arcury; Fiscal Year: 2009....
- Innovative HCW Training: Infectious Disease RiskRobyn Gershon; Fiscal Year: 2002..While, safety training programs are acknowledged as an important part of an overall risk management strategy, there are however, ..
- Evaluation of Atomoxetine for Cocaine Dependence: A Pilot TrialSharon Walsh; Fiscal Year: 2008..A broad array of measures, including measures of drug use, safety, mood, psychosocial functioning, and medication compliance (including riboflavin testing and pill counts) and ..
- Evaluation of Novel Treatments for Stimulant DependenceSharon Walsh; Fiscal Year: 2008..a novel agent, aripiprazole, for the treatment of cocaine dependence while simultaneously providing the requisite safety data needed to launch an outpatient clinical trial and exploring the potential efficacy of this agent for smoking ..
- Determining the Merit of Self-Rated Health for Risk PredictionKaren Desalvo; Fiscal Year: 2008..Karen DeSalvo to launch a successful, independent career in applied health services research focusing on interventions to improve the health of disadvantaged populations. [unreadable] [unreadable] [unreadable] [unreadable]..
- Psychosocial Influences on Systemic LupusCAROL GRECO; Fiscal Year: 2008..abstract_text> ..
- Modifying the School Environment to Reduce Violence: Suggestions from StudentsSARAH LINDSTROM JOHNSON; Fiscal Year: 2008..Hopefully, this knowledge will assist schools in identifying aspects of their school environment to modify in order to reduce the likelihood of violence. [unreadable] [unreadable] [unreadable]..
- CNS Viral Dynamics and Cellular Immunity During AIDSDavid Haas; Fiscal Year: 2009..Characterizing these relationships will expand our knowledge regarding key events that lead to AIDS dementia, and may suggest novel approaches to other immunologic or viral-mediated diseases that affect the brain. ..
- IMPACT OF INTIMATE ASSAULT ARREST ON BATTERED WOMENS SAFETY AND SERVICE NEEDSMELISSA DICHTER; Fiscal Year: 2007..The empirical literature has yet to identify the impact that being arrested has on a battered woman's safety and service needs; such knowledge is crucial for informing prevention and intervention effort to reduce women'..
- ASTHMA CLINICAL RESEARCH NETWORK (ACRN)Stephen Peters; Fiscal Year: 2007....
- School Environmental Exposures and Measures of the Asthmatic Disease ProcessELANOR SIDMAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- MELANOMA CONTROL FOR SIBLING OF MELANOMA PATIENTSBarbara Gilchrest; Fiscal Year: 2001....
- Emotional Mechanisms /Blood-Injection-Injury PhobiaOlubunmi Olatunji; Fiscal Year: 2004..This research will provide an important contribution to the understanding of the emotions that mediate BII phobia, thus potentially providing a foundation for incorporating effective treatment strategies. ..
- Brief Child Safety Interventions in Emergency DepartmentAndrea Gielen; Fiscal Year: 2004..We propose to evaluate a theoretically driven and innovative brief intervention for child safety delivered in the Pediatric Emergency Department (PED) of the Johns Hopkins Hospital, which serves a high risk, ..
- Casa A Campo: Pesticide Safety for Farmworkers' FamiliesThomas Arcury; Fiscal Year: 2004....
- Telomere homolog oligonucleotides for cancer therapyBarbara Gilchrest; Fiscal Year: 2004..extend our previous in vitro data, to select an optimal T-oligo for clinical testing, to perform dosing ranging (safety) studies in mice, and then to characterize the therapeutic effects of T-oligos in mouse models of human melanoma ..
- Evaluation of California Initiatives to Reduce Violence*Corinne Peek Asa; Fiscal Year: 2004..The first initiative was Cal/OSHA's 1993 release of "Guidelines for Security and Safety of Health Care and Community Service Workers...
- Violence,PTSD Symptoms & Substance UseTAMI SULLIVAN; Fiscal Year: 2004..Data collection will be cross-sectional. ..
- Epidemiologic Methods: Resistant Nosocomial InfectionsMarc Lipsitch; Fiscal Year: 2004..This will in turn lead to better practices to reduce the incidence of ARNI. ..
- A New Measure of Nursing Home Care QualityMarilyn Rantz; Fiscal Year: 2003..abstract_text> ..
- MAKING HEAT STRESS ASSESSMENT RELEVANT AGAINThomas Bernard; Fiscal Year: 2002..In the third year, the emphasis will be on high heat exposures that result in limited work times. This last year will be the test of the heat exchange model and the source of data for the empirical exposure limits. ..
- PHYSICIAN INTERVENTION TO IMPROVE DIABETES CAREPATRICK O CONNOR; Fiscal Year: 2002..The study will have substantial impact on clinical practice and policy whether the results are positive or negative. If successful, the interventions will be easily disseminated to other primary care practice settings. ..
- Prevalence of HIV/STDs among Incarcerated JuvenilesAngela Robertson; Fiscal Year: 2002..Grant funds will be used to provide STD screening, STD treatment referral, and HIV testing and counseling to juveniles in detention. ..
- CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANSStephen Peters; Fiscal Year: 2001....
- NIOSH SURVEILLANCE RESEARCH METHODOLOGYDavid Parker; Fiscal Year: 2001..Data analysis will consist of three parts: (1) Descriptive statistics; (2) Timeliness; and (3) Computation of incidence rates by industry. ..
- FEAR AND THE ANXIETY DISORDERS: BRAIN AND BEHAVIORPeter Lang; Fiscal Year: 2001..and furthermore, to evaluate memorial, cognitive style, and temperament differences among anxiety disorders, to sharpen differential diagnosis and assess the significance of depressive co-morbidity. ..
- COSTS AND BENEFITS OF ALCOHOL SERVICES & INTERVENTIONSMichael French; Fiscal Year: 2005..S. as well as abroad, the proposed study holds important potential to assist researchers, policymakers, and program directors with economic evaluation guidelines and "real world" applications. ..
- BAC Test Refusals: Are Impaired Driving Laws Threatened?Tara Kelley Baker; Fiscal Year: 2006..The results of the study will be useful to state policymakers who face federal legislation that provides incentives for states to increase the severity of the penalties for refusal. [unreadable] [unreadable]..
- Evaluating Child Safety Product Dissemination and Educa*Andrea Gielen; Fiscal Year: 2005..abstract not provided ..
- Proteomics of DEP-induced Oxidative StressAndre Nel; Fiscal Year: 2006..They will also use a display of protein carbonyls to identity oxidatively modified proteins in the BAL fluid. ..
- Culture and Mobility Device Use in Older AdultsLinda Resnik; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- 23rd - 27th Annual National Neurotrauma SymposiumW Dietrich; Fiscal Year: 2005..In addition, there are two sessions for open communications as well as a panel discussions led by Women in Neurotrauma Research. Specific information regarding the organization of future meetings is also discussed. ..
- Innovative MRI Research TechnologyPAUL BOTTOMLEY; Fiscal Year: 2005..The work will be implemented at 1 .5T and will directly and positively benefit 21 other funded research grants at this institution, with broad potential benefit to noninvasive imaging in a wide range of patients and diseases. ..
- A Dynamic Model of Supervision and Injury Among ChildrenRobert Cole; Fiscal Year: 2006..abstract not provided ..
- SODIUM IMAGING IN ISCHEMIC HEART DISEASEPAUL BOTTOMLEY; Fiscal Year: 2002..The availability of thousands of clinical MRI scanners offers a great opportunity for advancing 23Na MRI as a tool for assessing sodium pump function in human heart disease. ..
- Border Girls: AOD Use, Abuse, and VictimizationTara Kelley Baker; Fiscal Year: 2009..abstract_text> ..
- Certified Safe Farm Evaluating Health Insurance ClaimsKelley Donham; Fiscal Year: 2006Agriculture is one of the most hazardous industries in the US. A recent systematic review of farm safety interventions found little evidence of the interventions being effective...
- Evaluating Impact of a Resource Center for Drug UsersALEXANDER KRAL; Fiscal Year: 2005..Qualitative interviews will also be conducted with clients (N=30) and staff (N=6), to gain a richer contextual understanding of the impacts of the MNRC. ..
- Estrogen and Mechanisms of Cardiomyocyte ProtectionRichard Karas; Fiscal Year: 2009....
- MR Studies of Myocardial Creatine Kinase MetabolismPAUL BOTTOMLEY; Fiscal Year: 2007....
- Correlates of Sexual Risk for HIV/STI Among Women Who Use MethamphetamineALEXANDER KRAL; Fiscal Year: 2008..The proposed study addresses an understudied and important public health issue: MA use among women. [unreadable] [unreadable] [unreadable]..
- Qualitative Exploration of Low-Frequency Heroin Injectors Not in Drug TreatmentALEXANDER KRAL; Fiscal Year: 2009..An in-depth assessment of low-FHI can inform treatment approaches and expand our knowledge base regarding variations in heroin use among urban poor populations. ..
- An Automated System to Monitor Medical Device SafetyFrederic Resnic; Fiscal Year: 2009Post-market safety surveillance of medical devices is a complex task compounded by rapid dissemination of new medical technology, lack of standards in data collection, and inadequate passive adverse event reporting mechanisms...
- Gastric Tube Placement in Young ChildrenMarsha Ellett; Fiscal Year: 2008..Tube placement in children is especially understudied. Increasing the safety of NG/OG feeding in this population requires knowledge development in three areas---predicting the insertion ..
- Patient Oriented Research in Pediatric NutritionNancy Krebs; Fiscal Year: 2008..abstract_text> ..
- Social Ecology of Urban Adolescent Substance Abuse: A Multiple Domain ApproachMichael Mason; Fiscal Year: 2008..Integrated individual, social network and geographical data can serve as a model to direct the development of future innovative substance abuse preventive interventions for urban youth. [unreadable] [unreadable] [unreadable]..
- THERAPEUTIC POTENTIAL OF KAPPA-OPIOIDS AGAINST COCAINESharon Walsh; Fiscal Year: 2002..A series of four controlled laboratory studies are proposed that will systematically evaluate the safety and efficacy of two kappa agonists in humans when given alone and in combination with cocaine...
- GIS, ALCOHOL MARKETING, AND ALCOHOL-RELATED OUTCOMESDeborah Cohen; Fiscal Year: 2006..Because alcohol marketing is already regulated, if certain marketing techniques are disproportionately associated with alcohol consumption and alcohol-related mortality, the findings can be used to inform public policy. ..
- Factors in Drug DependenceSharon Walsh; Fiscal Year: 2005..abstract_text> ..
- ALCOHOL OUTLETS, BROKEN WINDOWS, GONORRHEA AND HIV RISKDeborah Cohen; Fiscal Year: 2003..The findings will inform future HIV prevention interventions and provide guidance to CBOs as to whether control of alcohol outlets and neighborhood development may enhance the prevention of HIV transmission. ..
- Acu/Moxa for Peripheral Neuropathy in Pts with HIVJOYCE ANASTASI; Fiscal Year: 2007..The effects of symptom reduction on quality of life will also be examined. In addition, this application originates from an institution with a NIH Center for AIDS Research (CFAR) and a supportive community network. ..
- Predicting Driver Safety in Parkinson's DiseaseErgun Uc; Fiscal Year: 2007..We propose to expand the available knowledge of driving safety in PD by testing a set of hypotheses in experiments that will assess (1) motor function using standardized ..
- Energy Absorbing Transit Safe Wheelchair CasterLINDA VANROOSMALEN; Fiscal Year: 2004..Upon successful completion of Phase I, FrogLegs will pursue Phase II STTR funding to further develop the transit safe caster-fork assembly for daily use on a variety of wheelchairs. ..
- ACTION - A CHF Trial Investigating Outcomes of ExerciseSteven Keteyian; Fiscal Year: 2007The primary aim of the ACTION Trial is to determine the long-term safety and effectiveness of exercise training for New York Heart Association Classes II-IV congestive heart failure patients in addition to standard of care versus a ..
- Genetic Predictors of Outcome in Acute MIMarc Sabatine; Fiscal Year: 2005..Genomic control will be employed to detect and control for population stratification. Interaction terms will be incorporated into regression models to explore gene-environment and pharmacogenomic interactions. ..
- Early Diagnosis of Neonatal CandidiasisDaniel Benjamin; Fiscal Year: 2008..abstract_text> ..
- Antidepressant Use and SuicideSusan Busch; Fiscal Year: 2009..The significance of this project lies in its potential to help clinicians and policymakers assess and manage competing risk and benefit claims. ..