health

Summary

Summary: The state of the organism when it functions optimally without evidence of disease.

Top Publications

  1. ncbi Gut microbiota composition correlates with diet and health in the elderly
    Marcus J Claesson
    Department of Microbiology, University College Cork, Ireland
    Nature 488:178-84. 2012
  2. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
  3. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
  4. ncbi Gut microbiota in health and disease
    Inna Sekirov
    Michael Smith Laboratories, Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Rev 90:859-904. 2010
  5. pmc Too much sitting: the population health science of sedentary behavior
    Neville Owen
    The University of Queensland, School of Population Health, Cancer Prevention Research Centre, Brisbane, Australia
    Exerc Sport Sci Rev 38:105-13. 2010
  6. ncbi Mesenchymal stem cells in health and disease
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Nat Rev Immunol 8:726-36. 2008
  7. pmc The gut microbiota shapes intestinal immune responses during health and disease
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Immunol 9:313-23. 2009
  8. pmc Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    Julie A Mattison
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
    Nature 489:318-21. 2012
  9. ncbi Inflammasomes in health and disease
    Till Strowig
    Department of Immunobiology, Yale University, Connecticut 06520, USA
    Nature 481:278-86. 2012
  10. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008

Detail Information

Publications249 found, 100 shown here

  1. ncbi Gut microbiota composition correlates with diet and health in the elderly
    Marcus J Claesson
    Department of Microbiology, University College Cork, Ireland
    Nature 488:178-84. 2012
    ..Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
  2. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
    ..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review...
  3. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related ..
  4. ncbi Gut microbiota in health and disease
    Inna Sekirov
    Michael Smith Laboratories, Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Rev 90:859-904. 2010
    ..Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease...
  5. pmc Too much sitting: the population health science of sedentary behavior
    Neville Owen
    The University of Queensland, School of Population Health, Cancer Prevention Research Centre, Brisbane, Australia
    Exerc Sport Sci Rev 38:105-13. 2010
    Even when adults meet physical activity guidelines, sitting for prolonged periods can compromise metabolic health. Television (TV) time and objective measurement studies show deleterious associations, and breaking up sedentary time is ..
  6. ncbi Mesenchymal stem cells in health and disease
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Nat Rev Immunol 8:726-36. 2008
    ..This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches...
  7. pmc The gut microbiota shapes intestinal immune responses during health and disease
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Immunol 9:313-23. 2009
    ..This raises the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms...
  8. pmc Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    Julie A Mattison
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
    Nature 489:318-21. 2012
    ..Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies...
  9. ncbi Inflammasomes in health and disease
    Till Strowig
    Department of Immunobiology, Yale University, Connecticut 06520, USA
    Nature 481:278-86. 2012
    ..We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases...
  10. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  11. ncbi Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
    Am J Clin Nutr 92:1189-96. 2010
    The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes.
  12. ncbi Glutathione metabolism and its implications for health
    Guoyao Wu
    Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    J Nutr 134:489-92. 2004
    ..New knowledge of the nutritional regulation of GSH metabolism is critical for the development of effective strategies to improve health and to treat these diseases.
  13. ncbi Climate change and human health: present and future risks
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, The Australian National University, Canberra 0200, Australia
    Lancet 367:859-69. 2006
    ..5 degrees C is partly attributable to such anthropogenic emissions. Climate change will affect human health in many ways-mostly adversely...
  14. ncbi Understanding the role of gut microbiome-host metabolic signal disruption in health and disease
    Elaine Holmes
    Department of Surgery and Cancer, Imperial College London, London, UK
    Trends Microbiol 19:349-59. 2011
    There is growing awareness of the importance of the gut microbiome in health and disease, and recognition that the microbe to host metabolic signalling is crucial to understanding the mechanistic basis of their interaction...
  15. ncbi Macrophage polarization and plasticity in health and disease
    Subhra K Biswas
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR Biopolis, 04 Immunos, 8A Biomedical Grove, Singapore
    Immunol Res 53:11-24. 2012
    ..Thus, understanding the functional diversity of these cells in health and disease as well as the mechanisms that control these events would be crucial for designing strategies for ..
  16. pmc Protein S-nitrosylation in health and disease: a current perspective
    Matthew W Foster
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Trends Mol Med 15:391-404. 2009
    ....
  17. ncbi Silver nanoparticle applications and human health
    Maqusood Ahamed
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    Clin Chim Acta 411:1841-8. 2010
    ..This paper summarizes and critically assesses the current studies focusing on adverse effects of Ag NPs on human health.
  18. ncbi Absorption and metabolism of polyphenols in the gut and impact on health
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Biomed Pharmacother 56:276-82. 2002
    ..Their study will be essential to better assess the health effects of dietary polyphenols...
  19. ncbi A clockwork web: circadian timing in brain and periphery, in health and disease
    Michael H Hastings
    Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Neurosci 4:649-61. 2003
  20. ncbi Regulation of matrix metalloproteinase activity in health and disease
    Elin Hadler-Olsen
    Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Norway
    FEBS J 278:28-45. 2011
    ..Knowledge about regulation of MMP activity is essential for understanding various physiological processes and pathogenesis of diseases, as well as for the development of new MMP targeting drugs...
  21. pmc Chemokines in health and disease
    Dayanidhi Raman
    Department of Cancer Biology, Vanderbilt University, School of Medicine, USA
    Exp Cell Res 317:575-89. 2011
    ..This article reviews the role of chemokines and their receptors in normal and disease processes and the potential for using chemokine antagonists for appropriate targeted therapy...
  22. ncbi Brain corticosteroid receptor balance in health and disease
    E R de Kloet
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, University of Leiden, The Netherlands
    Endocr Rev 19:269-301. 1998
    ..7. The set points of HPA regulation and MR/GR balance are genetically programmed, but can be reset by early life experiences involving mother-infant interaction. 8. (ABSTRACT TRUNCATED)..
  23. ncbi Dietary phenolics: chemistry, bioavailability and effects on health
    Alan Crozier
    Graham Kerr Building, Division of Ecology and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Nat Prod Rep 26:1001-43. 2009
    ..In addition, the intracellular concentrations required to affect cell signalling pathways are considerably lower than those required to impact on antioxidant capacity. The mechanisms underlying these processes are discussed...
  24. ncbi The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease
    M Fardilha
    Centre for Cell Biology, University of Aveiro, Aveiro, Portugal
    Curr Med Chem 17:3996-4017. 2010
    ..Further, it compiles 129 PP1-PIP relevant physiological interactions that are well documented in the literature. Finally, the use of PIPs as therapeutic targets will be addressed...
  25. ncbi Bacteria, colonic fermentation, and gastrointestinal health
    George T Macfarlane
    University of Dundee, Ninewells Hospital Medical School, Microbiology and Gut Biology Group, Dundee DD1 9SY, United Kingdom
    J AOAC Int 95:50-60. 2012
    ..However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel...
  26. pmc High adherence is necessary to realize health gains from water quality interventions
    Joe Brown
    Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e36735. 2012
    Safe drinking water is critical for health. Household water treatment (HWT) has been recommended for improving access to potable water where existing sources are unsafe...
  27. ncbi Regulation of caspases in the nervous system implications for functions in health and disease
    Carol M Troy
    Department of Pathology and Cell Biology, Taub Center for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, USA
    Prog Mol Biol Transl Sci 99:265-305. 2011
    ..activity pathways, the current tools for examining caspases, and functions of caspases in the nervous system in health and in disease...
  28. ncbi Essential fatty acids in health and chronic disease
    A P Simopoulos
    Center for Genetics, Nutrition and Health, Washington, DC 20009
    Am J Clin Nutr 70:560S-569S. 1999
    ..alpha-linolenic acid, found in green leafy vegetables, flaxseed, rapeseed, and walnuts, desaturates and elongates in the human body to EPA and DHA and by itself may have beneficial effects in health and in the control of chronic diseases.
  29. ncbi Selenium in human health and disease
    Susan J Fairweather-Tait
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, United Kingdom
    Antioxid Redox Signal 14:1337-83. 2011
    ..The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility,..
  30. pmc Zinc homeostasis and signaling in health and diseases: Zinc signaling
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
    J Biol Inorg Chem 16:1123-34. 2011
    ..trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory dysfunctions...
  31. pmc The meaning and the measure of health literacy
    David W Baker
    Division of General Internal Medicine and the Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Gen Intern Med 21:878-83. 2006
  32. pmc Assessment of heat-related health impacts in Brisbane, Australia: comparison of different heatwave definitions
    Shilu Tong
    School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    PLoS ONE 5:e12155. 2010
    ..We investigated the relationship between heatwaves and health outcomes using ten different heatwave definitions in Brisbane, Australia.
  33. pmc Health-related knowledge and preferences in low socio-economic kindergarteners
    Dan Nemet
    Child Health and Sports Center, Pediatric Department, Meir Medical Center, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Israel
    Int J Behav Nutr Phys Act 9:1. 2012
    ..The aim of the present study was to determine physical activity (PA) and nutrition knowledge and preferences in low socio-economic status kindergarten children...
  34. pmc Health: perception versus observation
    Amartya Sen
    BMJ 324:860-1. 2002
  35. ncbi Implications of gene copy-number variation in health and diseases
    Suhani H Almal
    Department of Cellular and Molecular Medicine, BV Patel Pharmaceutical Education and Research Development Centre, Thaltej Gandhinagar Highway, Ahmedabad, India
    J Hum Genet 57:6-13. 2012
    ..The large structural variations (>3 Mb) have been known for past 20 years, however, their link to health and disease remain ill-defined...
  36. ncbi Early nutrition programming of long-term health
    Berthold Koletzko
    Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Proc Nutr Soc 71:371-8. 2012
    ..and many other investigators demonstrates that early nutrition and lifestyle have long-term effects on later health and the risk of common non-communicable diseases (known as 'developmental programming')...
  37. ncbi Programmed necrosis from molecules to health and disease
    Lorenzo Galluzzi
    INSERM, Villejuif, France
    Int Rev Cell Mol Biol 289:1-35. 2011
    ..We then provide evidence suggesting that necroptosis represents an ancient and evolutionarily conserved cell death modality that may be targeted for drug development...
  38. ncbi Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology
    Volker Brinkmann
    Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH 4002 Basel, Switzerland
    Pharmacol Ther 115:84-105. 2007
    ..This review provides an overview on S1P activities and S1P receptor function in health and disease, and summarizes the clinical experience with FTY720 in transplantation and multiple sclerosis.
  39. ncbi Epigenetic mechanisms linking early nutrition to long term health
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Best Pract Res Clin Endocrinol Metab 26:667-76. 2012
    ..This review will focus on how nutritional cues in early life can alter the epigenome, producing different phenotypes and altered disease susceptibilities...
  40. ncbi Nanomaterials in the construction industry: a review of their applications and environmental health and safety considerations
    Jaesang Lee
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    ACS Nano 4:3580-90. 2010
    ..responsible nanotechnology in construction, it is important to consider the lifecycle impacts of MNMs on the health of construction workers and dwellers, as well as unintended environmental effects at all stages of manufacturing, ..
  41. pmc Plant polyphenols as dietary antioxidants in human health and disease
    Kanti Bhooshan Pandey
    Department of Biochemistry, University of Allahabad, Allahabad, India
    Oxid Med Cell Longev 2:270-8. 2009
    ..In the last decade, there has been much interest in the potential health benefits of dietary plant polyphenols as antioxidant...
  42. pmc Developing a new perspective to study the health of survivors of Sichuan earthquakes in China: a study on the effect of post-earthquake rescue policies on survivors' health-related quality of life
    Ying Liang
    Department of Social Work and Social Policy, School of Social and Behavioral Sciences, Nanjing University, Nanjing 210023, People s Republic of China
    Health Res Policy Syst 11:41. 2013
    ..Therefore, this study develops a new perspective to study the health of earthquake survivors, based on the effect of post-earthquake rescue policies on health-related quality of life (..
  43. ncbi Too much sitting--a health hazard
    David W Dunstan
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes Res Clin Pract 97:368-76. 2012
    ..involves very low energy expenditure, such as television viewing and desk-bound work) is adversely associated with health outcomes, including cardio-metabolic risk biomarkers, type 2 diabetes and premature mortality...
  44. ncbi The role of nutrition on epigenetic modifications and their implications on health
    Josep C Jimenez-Chillaron
    Fundació Sant Joan de Déu, Paediatric Hospital Sant Joan de Deu, Spain
    Biochimie 94:2242-63. 2012
    Nutrition plays a key role in many aspects of health and dietary imbalances are major determinants of chronic diseases including cardiovascular disease, obesity, diabetes and cancer...
  45. pmc Tackling the wider social determinants of health and health inequalities: evidence from systematic reviews
    C Bambra
    Department of Geography, Wolfson Research Institute, Durham University Queen s Campus, Stockton on Tees TS17 6BH, UK
    J Epidemiol Community Health 64:284-91. 2010
    There is increasing pressure to tackle the wider social determinants of health through the implementation of appropriate interventions...
  46. pmc Insights from past millennia into climatic impacts on human health and survival
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, Australian National University, Canberra ACT 0200, Australia
    Proc Natl Acad Sci U S A 109:4730-7. 2012
    Climate change poses threats to human health, safety, and survival via weather extremes and climatic impacts on food yields, fresh water, infectious diseases, conflict, and displacement...
  47. pmc The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease
    E Mogilyansky
    Computational Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Death Differ 20:1603-14. 2013
    ..and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding ..
  48. pmc Defining research to improve health systems
    Jan H F Remme
    UNICEF UNDP World Bank World Health Organization Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
    PLoS Med 7:e1001000. 2010
    Robert Terry and colleagues present working definitions of operational research, implementation research, and health systems research within the context of research to strengthen health systems.
  49. ncbi Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
    J N Crawley
    Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
    Brain Res 835:18-26. 1999
    ..Preliminary observations evaluate general health and neurological reflexes. Sensory abilities and motor functions are extensively quantitated...
  50. ncbi Limiting the impact of light pollution on human health, environment and stellar visibility
    Fabio Falchi
    Istituto di Scienza e Tecnologia dell Inquinamento Luminoso, Via Roma 13, I 36106 Thiene, Italy
    J Environ Manage 92:2714-22. 2011
    ..Here we propose a new way to limit the effects of this residual light pollution on wildlife, human health and stellar visibility...
  51. ncbi An ecological and evolutionary perspective on human-microbe mutualism and disease
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    Nature 449:811-8. 2007
    ..fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease...
  52. ncbi Relevance, essentiality and toxicity of trace elements in human health
    Cesar G Fraga
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Mol Aspects Med 26:235-44. 2005
    ..In humans Mn, Fe, Cu, Zn, and Se accomplish decisive functions to maintain human health. Deficiency in any of these TE leads to undesirable pathological conditions that can be prevented or reversed by ..
  53. ncbi Does positive affect influence health?
    Sarah D Pressman
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychol Bull 131:925-71. 2005
    This review highlights consistent patterns in the literature associating positive affect (PA) and physical health. However, it also raises serious conceptual and methodological reservations...
  54. pmc Identification and characterization of microRNAs in Clonorchis sinensis of human health significance
    Min Jun Xu
    Department of Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, PR China
    BMC Genomics 11:521. 2010
    ..sinensis residing chronically in the biliary tract, we developed an integrative approach combining deep sequencing and bioinformatic predictions with stem-loop real-time PCR analysis...
  55. ncbi Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster
    Kyu Sun Lee
    Aging Research Center, Korean Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Rejuvenation Res 13:561-70. 2010
    ....
  56. ncbi Fusobacterium nucleatum in periodontal health and disease
    Benoit Signat
    Department of Oral Biology, Faculty of Dental Surgery, University Paul Sabatier, Toulouse, France
    Curr Issues Mol Biol 13:25-36. 2011
    ..Antimicrobial peptides are important contributors to maintaining the balance between health and disease in this complex environment...
  57. ncbi Environmental epigenomics in human health and disease
    Dana C Dolinoy
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Mol Mutagen 49:4-8. 2008
    ....
  58. ncbi The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease
    Nathan Karin
    Department of Immunology, Bruce Rappaport Faculty of Medicine and Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, 1 Efron St, Haifa 31096, Israel
    J Leukoc Biol 88:463-73. 2010
    ..The current review explores the different biological properties of CXCL12 and discusses the implications of CXCL12-based therapies for autoimmunity and cancer diseases...
  59. ncbi Riboflavin (vitamin B-2) and health
    Hilary J Powers
    Centre for Human Nutrition, The University of Sheffield, United Kingdom
    Am J Clin Nutr 77:1352-60. 2003
    ..This article reviews current evidence that diets low in riboflavin present specific health risks...
  60. pmc Antioxidants prevent health-promoting effects of physical exercise in humans
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Proc Natl Acad Sci U S A 106:8665-70. 2009
    ..Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown...
  61. pmc Probiotic bacteria induce a 'glow of health'
    Tatiana Levkovich
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e53867. 2013
    Radiant skin and hair are universally recognized as indications of good health. However, this 'glow of health' display remains poorly understood...
  62. ncbi Vegetarian diets, low-meat diets and health: a review
    Claire T McEvoy
    Centre for Public Health, Queen s University Belfast, Institute of Clinical Science B, Belfast, UK
    Public Health Nutr 15:2287-94. 2012
    To review the epidemiological evidence for vegetarian diets, low-meat dietary patterns and their association with health status in adults.
  63. ncbi Mediterranean diet and health
    Francesco Sofi
    Department of Clinical and Experimental Medicine, University of Florence, Italy
    Biofactors 39:335-42. 2013
    ..To date, all the major scientific associations as well as the World Health Organization and the nonscientific organizations place an ever-increasing emphasis on the role of diet in ..
  64. pmc Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey
    Yoel Lubell
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e17439. 2011
    ..However, data on these key parameters are lacking and assumptions are frequently made based on expert opinion. Widely diverse opinions can lead to conflicting outcomes in models they inform...
  65. ncbi Glucocorticoids and the regulation of memory in health and disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Front Neuroendocrinol 30:358-70. 2009
    ..In this context, we review data suggesting that the administration of glucocorticoids might ameliorate chronic anxiety by reducing retrieval of aversive memories and enhancing fear extinction...
  66. pmc Relationship between vitamin D, parathyroid hormone, and bone health
    A J Sai
    Bone Metabolism Unit, Department of Medicine, Creighton University Medical Center, 601 North 30 Street, Suite 6718, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E436-46. 2011
    There is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health.
  67. ncbi Autophagy: a lysosomal degradation pathway with a central role in health and disease
    Eeva Liisa Eskelinen
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, PO Box 56, FIN 00014 Helsinki, Finland
    Biochim Biophys Acta 1793:664-73. 2009
    ..autophagy has been shown to possess important housekeeping and quality control functions that contribute to health and longevity...
  68. pmc AMPK and the biochemistry of exercise: implications for human health and disease
    Erik A Richter
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, August Krogh Building, 13 Universitetsparken, 2100 Copenhagen, Denmark
    Biochem J 418:261-75. 2009
    ..We also discuss the potential role of AMPK activation in mediating the prevention and treatment by exercise of specific disorders associated with the metabolic syndrome, including Type 2 diabetes and Alzheimer's disease...
  69. pmc Dynamics of human adipose lipid turnover in health and metabolic disease
    Peter Arner
    Department of Medicine, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    Nature 478:110-3. 2011
    ..Little is known, however, about adipose lipid turnover in humans in health and pathology...
  70. ncbi Green space, health inequality and pregnancy
    Payam Dadvand
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Int 40:110-5. 2012
    Green spaces have been suggested to improve physical and mental health and well-being by increasing physical activity, reducing air pollution, noise, and ambient temperature, increasing social contacts and relieving psychophysiological ..
  71. pmc Ecological perspectives in health research
    Lindsay McLaren
    Centre for Health and Policy Studies, G230, Health Sciences Centre, University of Calgary, 3330 Hospital Dr NW, Calgary AB, Canada
    J Epidemiol Community Health 59:6-14. 2005
    An ecological perspective on health emphasises both individual and contextual systems and the interdependent relations between the two. Origins of this approach have emanated from multiple disciplines over the past century or more...
  72. pmc The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Mol Aspects Med 29:361-8. 2008
    Vitamin D, the sunshine vitamin, is important for childhood bone health. Over the past two decades, it is now recognized that vitamin D not only is important for calcium metabolism and maintenance of bone health throughout life, but also ..
  73. ncbi Choline and betaine in health and disease
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Inherit Metab Dis 34:3-15. 2011
    ..Thus, choline and betaine showed opposite relations with key components of metabolic syndrome, suggesting a disruption of mitochondrial choline oxidation to betaine as part of the mitochondrial dysfunction in metabolic syndrome...
  74. ncbi Cyanobacterial toxins: risk management for health protection
    Geoffrey A Codd
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicol Appl Pharmacol 203:264-72. 2005
    ..occurrence and properties of cyanobacterial toxins, with reference to the recognition and management of the human health risks which they may present...
  75. pmc Change in chronic disability from 1982 to 2004/2005 as measured by long-term changes in function and health in the U.S. elderly population
    Kenneth G Manton
    Center for Demographic Studies, Duke University, Durham, NC 27708 0408, USA
    Proc Natl Acad Sci U S A 103:18374-9. 2006
    Changes in the health and functioning of the Medicare-enrolled population aged 65+ are tracked by using the 1982-2004/2005 National Long-Term Care Surveys...
  76. ncbi Calcium pumps in health and disease
    Marisa Brini
    Department of Biochemistry, University of Padova, Padova, Italy
    Physiol Rev 89:1341-78. 2009
    ..They do not bring cells to immediate death but seriously compromise their normal functioning...
  77. pmc Life cycle of connexins in health and disease
    Dale W Laird
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochem J 394:527-43. 2006
    ..This review will assess the current understanding of wild-type and selected disease-linked mutant connexin transport through the secretory pathway, gap-junction assembly at the cell surface, internalization and degradation...
  78. ncbi Myofibroblasts. I. Paracrine cells important in health and disease
    D W Powell
    University of Texas Medical Branch at Galveston, Departments of Internal Medicine, Physiology, and Biophysics and Pathology, Galveston, Texas 77555, USA
    Am J Physiol 277:C1-9. 1999
    ..Because of their ubiquitous presence in all tissues, myofibroblasts play important roles in various organ diseases and perhaps in multisystem diseases as well...
  79. ncbi Linking health and health-related information to the ICF: a systematic review of the literature from 2001 to 2008
    Nora Fayed
    School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada
    Disabil Rehabil 33:1941-51. 2011
    In 1976, the World Health Organization (WHO) estimated worldwide disability prevalence at 10%; recent evidence suggests the prevalence is even higher...
  80. ncbi Cell death in health and disease
    Richard A Lockshin
    Department of Biological Sciences, St John s University, Queens, NY 11439, USA
    J Cell Mol Med 11:1214-24. 2007
    ..In the future, the challenge will be more to understand the challenge to the cell from a more global standpoint, including many more aspects of metabolism, and work toward alleviating or provoking the challenge in a targeted fashion...
  81. ncbi Nutrigenomics: exploiting systems biology in the nutrition and health arenas
    Ben van Ommen
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Nutrition 20:4-8. 2004
  82. ncbi Mannose phosphorylation in health and disease
    Katrin Kollmann
    Department of Biochemistry, Children s Hospital, University Medical Center Hamburg Eppendorf, Research Campus, Martinistrasse 52, 20246 Hamburg, Germany
    Eur J Cell Biol 89:117-23. 2010
    ....
  83. pmc Molecular biology of K(ATP) channels and implications for health and disease
    Alejandro Akrouh
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    IUBMB Life 61:971-8. 2009
    ..Continuing studies of channel physiology and pathology will bring new insights to the molecular basis of K(ATP) channel function, leading to a better understanding of the role that K(ATP) channels play in both health and disease.
  84. ncbi The role of polyphenolic antioxidants in health, disease, and aging
    Mark E Obrenovich
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Rejuvenation Res 13:631-43. 2010
    ..On the other hand, questions still remain as to whether some antioxidants could be potentially harmful to health, because an increase in glycation-mediated protein damage (carbonyl stress) has been reported in some cases...
  85. ncbi Simultaneously mitigating near-term climate change and improving human health and food security
    Drew Shindell
    NASA Goddard Institute for Space Studies and Columbia Earth Institute, Columbia University, New York, NY 10025, USA
    Science 335:183-9. 2012
    ..The selected controls target different sources and influence climate on shorter time scales than those of carbon dioxide-reduction measures. Implementing both substantially reduces the risks of crossing the 2°C threshold...
  86. ncbi mTOR Signalling in Health and Disease
    Christopher G Proud
    School of Biological Sciences, Life Sciences Building, University of Southampton, Southampton SO17 1BJ, UK
    Biochem Soc Trans 39:431-6. 2011
    ....
  87. ncbi Diet induced epigenetic changes and their implications for health
    J A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Acta Physiol (Oxf) 202:103-18. 2011
    Dietary exposures can have consequences for health years or decades later and this raises questions about the mechanisms through which such exposures are 'remembered' and how they result in altered disease risk...
  88. ncbi Politics and health outcomes
    Vicente Navarro
    Johns Hopkins University, USA
    Lancet 368:1033-7. 2006
    The aim of this study was to examine the complex interactions between political traditions, policies, and public health outcomes, and to find out whether different political traditions have been associated with systematic patterns in ..
  89. ncbi Race and sex effects on the association between muscle strength, soft tissue, and bone mineral density in healthy elders: the Health, Aging, and Body Composition Study
    D R Taaffe
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
    J Bone Miner Res 16:1343-52. 2001
    ..and whole body bone mineral density (BMD) in a cohort of 2,619 well-functioning older adults participating in the Health, Aging, and Body Composition (Health ABC) Study with complete measures...
  90. pmc Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007
    Ali Montazeri
    Iranian Institute for Health Sciences Research, Tehran, Iran
    J Exp Clin Cancer Res 27:32. 2008
    ..Quality of life in patients with breast cancer is an important outcome. This paper presents an extensive overview on the topic ranging from descriptive findings to clinical trials...
  91. ncbi Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
    Melanie Auffan
    Center for the Environmental Implications of NanoTechnology CEINT, Duke University, 121 Hudson Hall, Durham, North Carolina 27707, USA
    Nat Nanotechnol 4:634-41. 2009
    ..criterion in any definition of nanoparticles when making decisions about their regulation for environmental, health and safety reasons...
  92. ncbi Money, schooling, and health: Mechanisms and causal evidence
    Ichiro Kawachi
    Department of Society, Human Development and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 1186:56-68. 2010
    An association between higher educational attainment and better health status has been repeatedly reported in the literature. Similarly, thousands of studies have found a relationship between higher income and better health...
  93. ncbi Developmental plasticity and human health
    Patrick Bateson
    Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, UK
    Nature 430:419-21. 2004
    ..however, rapid improvements in nutrition and other environmental conditions may have damaging effects on the health of those people whose parents and grandparents lived in impoverished conditions...
  94. ncbi Personality and the perception of health and happiness
    C Robert Cloninger
    Dept of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    J Affect Disord 128:24-32. 2011
    b>Health is a state of physical, mental, and social well-being...
  95. ncbi Disintegrins in health and disease
    Mary Ann McLane
    Department of Medical Technology, University of Delaware, 305G Willard Hall Education Building, Newark, DE 19716, USA
    Front Biosci 13:6617-37. 2008
    ..This review will summarize disintegrin investigations since 2003...
  96. ncbi The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
    S Papa
    The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Cell Death Differ 13:712-29. 2006
    ..Indeed, further delineating the mechanisms by which NF-kappaB promotes cell survival might hold the key to developing new highly effective therapies for treatment of widespread human diseases...
  97. ncbi Nitric oxide in health and disease of the respiratory system
    Fabio L M Ricciardolo
    Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Physiol Rev 84:731-65. 2004
    ....
  98. pmc Keratins in health and cancer: more than mere epithelial cell markers
    V Karantza
    Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Oncogene 30:127-38. 2011
    ....
  99. pmc Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states
    Amani Batarseh
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20057, USA
    Mol Cell Endocrinol 327:1-12. 2010
    ..The results described here provide evidence that the PKCepsilon-ERK1/2-AP-1/STAT3 signal transduction pathway is the primary regulator of Tspo gene expression in normal and pathological tissues expressing high levels of TSPO...
  100. ncbi OMICS-driven biomarker discovery in nutrition and health
    Martin Kussmann
    BioAnalytical Science Department, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    J Biotechnol 124:758-87. 2006
    ..nutrition research has dealt with providing nutrients to nourish populations, it nowadays focuses on improving health of individuals through diet...
  101. pmc Dietary factors, hormesis and health
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Ageing Res Rev 7:43-8. 2008
    The impact of dietary factors on health and longevity is increasingly appreciated. The most prominent dietary factor that affects the risk of many different chronic diseases is energy intake -- excessive calorie intake increases the risk...

Research Grants62

  1. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Juvenile dermatomyositis (JDM) is an autoimmune disease of children, in which there is damage to the ..
  2. Functional Analysis of the Embryonic Epigenome in a Non-rodent Model
    Mark E Westhusin; Fiscal Year: 2013
    ..From the standpoint of human reproductive health and human disease, understanding the factors and mechanisms which control epigenetic reprogramming during early ..
  3. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ....
  4. PPAR-gamma Signaling in Normal Pilosebaceous Units and in Scarring Alopecia
    Pratima Karnik; Fiscal Year: 2013
    ..PHS 398/2590 (Rev. 11/07) Page Continuation Format Page ..
  5. Factors affecting ice formation in cells and their relevance to cryopreservation
    Peter Mazur; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: The ability to preserve cells at very low temperatures has important implications and applications in ..
  6. Integration of Genomics & Transcriptomics in Normal Twins & Major Depression
    Patrick F Sullivan; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The work proposed here will create/preserve 21 American jobs...
  7. Just-In-Time Methods For Understanding Near-misses, Injuries &Risk Factors
    Nancy M Daraiseh; Fiscal Year: 2013
    ..with occupational diseases and injuries and adds to scientific knowledge by examining a population whose health and safety is seldom investigated...
  8. Genetic Interaction Between the pRB and Warts Tumor Suppressor Pathways
    Brandon Nicolay; Fiscal Year: 2010
    ..Thus, the outcome of this study could demonstrate that targeted inhibition of activator E2Fs could prove to be a productive anticancer therapy. ..
  9. Understanding Providers Stigmatization of SMI Among Veterans
    JAN GREER SULLIVAN; Fiscal Year: 2013
    ..A key group who have influence not only in the lives but also in the treatment of persons with SMI are mental health and primary care providers...
  10. Epigenetic Regulation of Mitochondiral Complex II
    Gerald S Shadel; Fiscal Year: 2010
    ..Understanding the molecular basis of imprinting in PGL may provide general insights on how differential expression of a single defective gene can lead to disease or normalcy. ..
  11. Factors affecting ice formation in cells and their relevance to cryopreservation
    Peter Mazur; Fiscal Year: 2013
    ..Another possibility is that their efficacy depends more on the degree to which they osmotically dehydrate the cells prior to initiating cooling to -1960C, We propose to test that hypothesis in a quantitative manner. ..
  12. Vaginal Tactile Imager for Pelvic Floor Biomechanical Assessment
    Vladimir Egorov; Fiscal Year: 2013
    ..The VTI commercialization will follow the FDA approval. The completion of proposed project promises to gain scientific knowledge, provide new technical capability and improve clinical practice in gynecology. ..
  13. Promoting Asthma Self-Care in Urban African American Teens
    BARBARA F VELSO; Fiscal Year: 2010
    ..Asthma is responsible for 14 million lost school days and $14 billion in health care and lost productivity costs...
  14. Pluripotent Stem Cells in Development and Disease
    Gerald Schatten; Fiscal Year: 2010
    ..abstract_text> ..
  15. Characterization of human hematopoietic and endodermal progenitors derived from i
    Gustavo Mostoslavsky; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Cystic fibrosis and alpha-1 antitrypsin deficiency-related emphysema are the two most common inherited ..
  16. A complex systems approach to bronchoconstriction in Asthma
    Tilo Winkler; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Asthma is a disease of multiple origins that is becoming increasingly common and affects more than 300 ..
  17. Flexible Statistical Methods for Biomedical Data
    Marie Davidian; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): An ongoing challenge in health sciences research is the development of statistical models used to study relationships between subject characteristics and interventions and disease onset, recurrence, ..
  18. Breast Cancer Detection Using Electrical Impedance Measurements
    Eugene Demidenko; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE The goal of this project is to develop a computer-aided system to detect abnormalities in breasts, ..
  19. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..The PI is at U CO Health Sciences; the second center is the Movement Disorders Unit at Columbia Presbyterian Medical Center in NY (Stanley ..
  20. Problems in testing gene-by-enviornment interaction in behavior genetic designs
    Benjamin B Lahey; Fiscal Year: 2010
    ..Significance: Genes rarely influence health and mental health in isolation...
  21. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  22. Novel assay for functional capacities of pluripotent stem cells
    ROGER ARNOLD PEDERSEN; Fiscal Year: 2013
    ..A similr approach will be used to determine the impact of key environmental toxicants, specifically C6H6 and MeHg, which are developmental toxicants for the blood and nervous systems, respectively. ..
  23. Prenatal Alcohol Exposure Dysregulates Fetal Iron Homeostasis
    Shane M Huebner; Fiscal Year: 2013
    ..abstract_text> ..
  24. Access to Care of Medicare and Medicaid Enrollees
    Marlene Niefeld; Fiscal Year: 2003
    ..Despite the provision of health insurance to low-income seniors, access to health care problems persist...
  25. Heme Oxygenase 2005 -- the 4th International Conference
    FRITZ BACH; Fiscal Year: 2005
    ..It prevents certain responses of the body, like inflammation, from becoming too strong and becoming destructive. The parts of the system will likely be useful to treat a wide variety of human disorders. ..
  26. Clinicians' Judgments of the Need for Psychological Treatment
    Nancy S Kim; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Expert and novice mental health clinicians have previously been shown to demonstrate an understanding-normality effect (Meehl, 1973), wherein having a plausible explanation for a client's bizarre ..
  27. HISTOMETRIC ANALYSIS OF PREMALIGNANT ENDOMETRIAL LESIONS
    Francisco Garcia; Fiscal Year: 2003
    ..abstract_text> ..
  28. Child-Initiated Communicative Interactions and Autism Intervention
    Robert L Koegel; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The Center for Disease Control has declared autism as an epidemic affecting 1 in 150 children, and is ..
  29. Software &Hardware Inference Engines for Automated Determination of Primary Cell
    Garry P Nolan; Fiscal Year: 2011
    ..We will contrast this database with the immune system changes that occur in cancer tumour infiltrating cells using two cancer systems. ..
  30. Innovative Analytic Methods of Person-Centered Data and Adaptive Designs for Alco
    JOHN M O apos QUIGLEY; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE (provided by applicant): In this grant proposal we will propose and apply several innovative models to ..
  31. OXIDATIVE DAMAGE AND IRON REQUIREMENTS OF THE BLASTOCYST
    COLE MANES; Fiscal Year: 1991
    ..Hormonally-induced superovulation will be employed as necessary to provide sufficient numbers of experimental and control embryos for statistical evaluation of the culture conditions tested...
  32. ABNORMALITIES IN CALVES FROM EMBRYO TRANSFER
    George Seidel; Fiscal Year: 1980
    ..Such information is essential for making informed decisions concerning experimental or clinical application of superovulation and transfer of human embryos and for predicting the consequences of using fertility drugs...
  33. Kangaroo Care to Blunt Pain in Premature Infants
    Susan Ludington; Fiscal Year: 2004
    ..If the normality assumption is violated, an appropriate transformation will be used before applying the T-test. ..
  34. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
    ..on mechanisms involvedin regulating oocyte normalcy and embryo developmental competence and pregnancy success when insulin-resistance, obesity, diabetes, and/or PCOS compromise women's health and fertility.
  35. LOW-DOSE ASA AND PREVENTION OF PREGNANCY HYPERTENSION
    John Hauth; Fiscal Year: 1991
    ..We will also quantify umbilical venous and arterial levels of salicylate TXB, 6-keto-PGH, and markers of the fetal hypothalamic- pituitary-adrenal axis. ..
  36. DNA DAMAGE IN MOUSE TUMORS EVAL BY IR SPECTROSCOPY
    DONALD MALINS; Fiscal Year: 2002
    ..Third, we shall evaluate how two chemotherapeutic drugs with different modes of action affect detectable DNA lesions, using the FT-IR technology, and attempt to correlate this with their activity in tumor formation. ..
  37. Disease Surveillance in Real Time: Geotemporal Methods
    Kenneth Mandl; Fiscal Year: 2009
    DESCRIPTION (provided by applicant):Real time data collection and analysis would substantially strengthen public health surveillance at both regional and national levels...
  38. CIND: Risk Factors for Conversion to Dementia
    Frederick W Unverzagt; Fiscal Year: 2010
    ..A random sample of 2000 patients aged 65 and older from the Wishard Health System primary care database will be evaluated and diagnosed...
  39. STUDIES ON MAMMALIAN OOCYTES (AND SPERMATOCYTES)
    GEORGIANA JAGIELLO; Fiscal Year: 1993
    ..The feasibility of the such studies has been demonstrated in a preliminary study with male Mesocricetus auratus...
  40. OVARIAN FUNCTION IN MARES CHRONICALLY TREATED WITH PZP
    Jay Kirkpatrick; Fiscal Year: 1992
    ..The use of urinary steroid metabolites to monitor ovarian function will preclude the need to capture or handle horses...
  41. ARACHIDONIC ACID METABOLITES AND UTERINE CONTRACTIONS
    W Chan; Fiscal Year: 1991
    ..The mechanism of action of PG on OT receptor and gap junction formations will be pursued. In vivo and in vitro rat models will be utilized to determine whether PG exerts its effects directly or indirectly via its luteolytic action...
  42. Human Microbiome Research and the Social Fabric
    Rosamond Rhodes; Fiscal Year: 2009
    ..Our project will bring together an interdisciplinary team of 27 health professionals, scientists, and scholars from the humanities and social sciences to explore key issues through an ..
  43. An open-source software for Bayesian neuroimaging data analysis
    Rong Chen; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This project centers on enhancing an open source Bayesian data mining tool to analyze neuroimaging data...
  44. Mixed-Effects ZIP Models--Mental Health Service Research
    Robert Gibbons; Fiscal Year: 2004
    The study of mental health service utilization is compromised by the lack of adequate statistical methods...
  45. FIBROBLASTIC HETEROGENEITY IN OROFACIAL SCARRING
    Charles Bertolami; Fiscal Year: 1993
    ....
  46. Children Dependent on Technology--Family and School Care
    Roberta Rehm; Fiscal Year: 2001
    ..education services and constant care and observation while at school to keep them safe and provide for their health and developmental needs...
  47. Expression Analysis to Study Disease Pathogenesis
    Mark Geraci; Fiscal Year: 2005
    ..Specific Aim 3 is designed to provide NHLBI researchers with a user-friendly, powerful Internet-based analysis tool. This tool will be specific for the needs of researchers in heart, lung, blood and sleep-related fields. ..
  48. SUBSAMPLING METHODS FOR SPATIAL AND LONGITUDINAL DATA
    Michael Sherman; Fiscal Year: 2000
    ..g., prevalence of disease. ..
  49. CRYOPRESERVATION OF EJACULATED AND EPIDIDYMAL SPERM
    Alan Trounson; Fiscal Year: 2001
    ..abstract_text> ..
  50. IMPACT OF MENTAL ILLNESS ON THE FAMILY
    JOHN CLAUSEN; Fiscal Year: 1980
    ..The time span covered permits inferences as to how major changes in community mental health facilities have influenced the meaning and consequences of the patient's illness for his or her family...
  51. Depression & Adherence in Head and Neck Cancer
    Eileen Shinn; Fiscal Year: 2005
    ..Pain, fatigue, and social support will be tested as mediators of the intervention's potential effect on depression levels. ..
  52. STATISTICAL METHODS FOR MAPPING MULTIVARIATE PHENOTYPES
    Saurabh Ghosh; Fiscal Year: 2007
    ..abstract_text> ..
  53. Longitudinal Comorbidity: Modeling Symptom, Syndrome, and Impairment Change
    SONYA STERBA; Fiscal Year: 2009
    ..Third, the proposed integrative model will be applied to provide the first simultaneous test of both etiological theories of successive comorbidity across the transition to adolescence, to our knowledge. ..
  54. Decision Rules for Multiple Endpoints in Clinical Trials
    AJIT TAMHANE; Fiscal Year: 2007
    ..The primary public health benefit of the proposed research is that it will facilitate correct statistical evaluation of multiple endpoints ..
  55. ANALYSIS OF EARNING INEQUALITY AND EARNINGS MOBILITY
    DOUGLAS GALE; Fiscal Year: 2002
    ..e., the level of annual consumption they can maintain given their life cycle income path) has changed. ..
  56. Regulating invasion in pancreatic tumorigenesis
    Douglas Hanahan; Fiscal Year: 2009
    ..Aim 3. Assess roles of IFG1R and EGFR-family signaling of the invasive switch in pancreatic ductal adenocarcinoma using a mouse model that recapitulates the human disease's lesional progression and oncogenic events. ..
  57. NORMAL IMAGE RECOGNITION TECHNICS FOR DIGITAL MAMMOGRAMS
    John Heine; Fiscal Year: 2000
    ....
  58. Prevention of Adolescent Driving Under the Influence
    DAVID MACKINNON; Fiscal Year: 2003
    ..In addition, more common statistical methods will be used to extract the maximum information from these data The findings in one project site will be cross-validated in the other site. ..
  59. Analysis Software to Characterize Myocardial Mechanics
    RICARDO ACTIS; Fiscal Year: 2004
    ....
  60. ESTIMATION & TEST OF MARKER ASSOCIATION IN FAMILY DATA
    Varghese George; Fiscal Year: 1992
    ..Extensions to different types of ascertainments will be developed. The methods will be applied to analyse pedigree data obtained from various ongoing studies in order to be sure that the methods are relevant to real data...
  61. STRESS EFFECTS ON PREGNANCY AND FETAL NORMALCY
    GAIL RIEGLE; Fiscal Year: 1980
    ..In addition, we are measuring the effect of sex steroids and stress on hypothalamic neurotransmitters which are believed to regulate the secretion of hypothalamic hormones which regulate pituitary function. ..
  62. TOPICS IN BIOSTATISTICS
    James Koziol; Fiscal Year: 1993
    ....