- Gut microbiota composition correlates with diet and health in the elderly
Marcus J Claesson
Department of Microbiology, University College Cork, Ireland
Nature 488:178-84. 2012
..Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
- Nitric oxide and peroxynitrite in health and disease
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Physiol Rev 87:315-424. 2007
..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review...
- Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A Baur
Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 444:337-42. 2006
..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related ..
- Gut microbiota in health and disease
Michael Smith Laboratories, Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada
Physiol Rev 90:859-904. 2010
..Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease...
- Too much sitting: the population health science of sedentary behavior
The University of Queensland, School of Population Health, Cancer Prevention Research Centre, Brisbane, Australia
Exerc Sport Sci Rev 38:105-13. 2010
Even when adults meet physical activity guidelines, sitting for prolonged periods can compromise metabolic health. Television (TV) time and objective measurement studies show deleterious associations, and breaking up sedentary time is ..
- Mesenchymal stem cells in health and disease
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
Nat Rev Immunol 8:726-36. 2008
..This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches...
- The gut microbiota shapes intestinal immune responses during health and disease
June L Round
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Nat Rev Immunol 9:313-23. 2009
..This raises the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms...
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Julie A Mattison
Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
Nature 489:318-21. 2012
..Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies...
- Inflammasomes in health and disease
Department of Immunobiology, Yale University, Connecticut 06520, USA
Nature 481:278-86. 2012
..We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases...
- Effect of in utero and early-life conditions on adult health and disease
Peter D Gluckman
Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
N Engl J Med 359:61-73. 2008
- Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
Am J Clin Nutr 92:1189-96. 2010
The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes.
- Glutathione metabolism and its implications for health
Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
J Nutr 134:489-92. 2004
..New knowledge of the nutritional regulation of GSH metabolism is critical for the development of effective strategies to improve health and to treat these diseases.
- Climate change and human health: present and future risks
Anthony J McMichael
National Centre for Epidemiology and Population Health, The Australian National University, Canberra 0200, Australia
Lancet 367:859-69. 2006
..5 degrees C is partly attributable to such anthropogenic emissions. Climate change will affect human health in many ways-mostly adversely...
- Understanding the role of gut microbiome-host metabolic signal disruption in health and disease
Department of Surgery and Cancer, Imperial College London, London, UK
Trends Microbiol 19:349-59. 2011
There is growing awareness of the importance of the gut microbiome in health and disease, and recognition that the microbe to host metabolic signalling is crucial to understanding the mechanistic basis of their interaction...
- Macrophage polarization and plasticity in health and disease
Subhra K Biswas
Singapore Immunology Network, Agency for Science, Technology and Research A STAR Biopolis, 04 Immunos, 8A Biomedical Grove, Singapore
Immunol Res 53:11-24. 2012
..Thus, understanding the functional diversity of these cells in health and disease as well as the mechanisms that control these events would be crucial for designing strategies for ..
- Protein S-nitrosylation in health and disease: a current perspective
Matthew W Foster
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Trends Mol Med 15:391-404. 2009
- Silver nanoparticle applications and human health
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
Clin Chim Acta 411:1841-8. 2010
..This paper summarizes and critically assesses the current studies focusing on adverse effects of Ag NPs on human health.
- Absorption and metabolism of polyphenols in the gut and impact on health
Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
Biomed Pharmacother 56:276-82. 2002
..Their study will be essential to better assess the health effects of dietary polyphenols...
- A clockwork web: circadian timing in brain and periphery, in health and disease
Michael H Hastings
Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Rev Neurosci 4:649-61. 2003
- Regulation of matrix metalloproteinase activity in health and disease
Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Norway
FEBS J 278:28-45. 2011
..Knowledge about regulation of MMP activity is essential for understanding various physiological processes and pathogenesis of diseases, as well as for the development of new MMP targeting drugs...
- Chemokines in health and disease
Department of Cancer Biology, Vanderbilt University, School of Medicine, USA
Exp Cell Res 317:575-89. 2011
..This article reviews the role of chemokines and their receptors in normal and disease processes and the potential for using chemokine antagonists for appropriate targeted therapy...
- Brain corticosteroid receptor balance in health and disease
E R de Kloet
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, University of Leiden, The Netherlands
Endocr Rev 19:269-301. 1998
..7. The set points of HPA regulation and MR/GR balance are genetically programmed, but can be reset by early life experiences involving mother-infant interaction. 8. (ABSTRACT TRUNCATED)..
- Dietary phenolics: chemistry, bioavailability and effects on health
Graham Kerr Building, Division of Ecology and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
Nat Prod Rep 26:1001-43. 2009
..In addition, the intracellular concentrations required to affect cell signalling pathways are considerably lower than those required to impact on antioxidant capacity. The mechanisms underlying these processes are discussed...
- The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease
Centre for Cell Biology, University of Aveiro, Aveiro, Portugal
Curr Med Chem 17:3996-4017. 2010
..Further, it compiles 129 PP1-PIP relevant physiological interactions that are well documented in the literature. Finally, the use of PIPs as therapeutic targets will be addressed...
- Bacteria, colonic fermentation, and gastrointestinal health
George T Macfarlane
University of Dundee, Ninewells Hospital Medical School, Microbiology and Gut Biology Group, Dundee DD1 9SY, United Kingdom
J AOAC Int 95:50-60. 2012
..However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel...
- High adherence is necessary to realize health gains from water quality interventions
Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 7:e36735. 2012
Safe drinking water is critical for health. Household water treatment (HWT) has been recommended for improving access to potable water where existing sources are unsafe...
- Regulation of caspases in the nervous system implications for functions in health and disease
Carol M Troy
Department of Pathology and Cell Biology, Taub Center for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, USA
Prog Mol Biol Transl Sci 99:265-305. 2011
..activity pathways, the current tools for examining caspases, and functions of caspases in the nervous system in health and in disease...
- Essential fatty acids in health and chronic disease
A P Simopoulos
Center for Genetics, Nutrition and Health, Washington, DC 20009
Am J Clin Nutr 70:560S-569S. 1999
..alpha-linolenic acid, found in green leafy vegetables, flaxseed, rapeseed, and walnuts, desaturates and elongates in the human body to EPA and DHA and by itself may have beneficial effects in health and in the control of chronic diseases.
- Selenium in human health and disease
Susan J Fairweather-Tait
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, United Kingdom
Antioxid Redox Signal 14:1337-83. 2011
..The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility,..
- Zinc homeostasis and signaling in health and diseases: Zinc signaling
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
J Biol Inorg Chem 16:1123-34. 2011
..trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory dysfunctions...
- The meaning and the measure of health literacy
David W Baker
Division of General Internal Medicine and the Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
J Gen Intern Med 21:878-83. 2006
- Assessment of heat-related health impacts in Brisbane, Australia: comparison of different heatwave definitions
School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
PLoS ONE 5:e12155. 2010
..We investigated the relationship between heatwaves and health outcomes using ten different heatwave definitions in Brisbane, Australia.
- Health-related knowledge and preferences in low socio-economic kindergarteners
Child Health and Sports Center, Pediatric Department, Meir Medical Center, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Israel
Int J Behav Nutr Phys Act 9:1. 2012
..The aim of the present study was to determine physical activity (PA) and nutrition knowledge and preferences in low socio-economic status kindergarten children...
- Health: perception versus observation
BMJ 324:860-1. 2002
- Implications of gene copy-number variation in health and diseases
Suhani H Almal
Department of Cellular and Molecular Medicine, BV Patel Pharmaceutical Education and Research Development Centre, Thaltej Gandhinagar Highway, Ahmedabad, India
J Hum Genet 57:6-13. 2012
..The large structural variations (>3 Mb) have been known for past 20 years, however, their link to health and disease remain ill-defined...
- Early nutrition programming of long-term health
Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany
Proc Nutr Soc 71:371-8. 2012
..and many other investigators demonstrates that early nutrition and lifestyle have long-term effects on later health and the risk of common non-communicable diseases (known as 'developmental programming')...
- Programmed necrosis from molecules to health and disease
INSERM, Villejuif, France
Int Rev Cell Mol Biol 289:1-35. 2011
..We then provide evidence suggesting that necroptosis represents an ancient and evolutionarily conserved cell death modality that may be targeted for drug development...
- Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology
Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH 4002 Basel, Switzerland
Pharmacol Ther 115:84-105. 2007
..This review provides an overview on S1P activities and S1P receptor function in health and disease, and summarizes the clinical experience with FTY720 in transplantation and multiple sclerosis.
- Epigenetic mechanisms linking early nutrition to long term health
Karen A Lillycrop
Centre for Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
Best Pract Res Clin Endocrinol Metab 26:667-76. 2012
..This review will focus on how nutritional cues in early life can alter the epigenome, producing different phenotypes and altered disease susceptibilities...
- Nanomaterials in the construction industry: a review of their applications and environmental health and safety considerations
Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
ACS Nano 4:3580-90. 2010
..responsible nanotechnology in construction, it is important to consider the lifecycle impacts of MNMs on the health of construction workers and dwellers, as well as unintended environmental effects at all stages of manufacturing, ..
- Plant polyphenols as dietary antioxidants in human health and disease
Kanti Bhooshan Pandey
Department of Biochemistry, University of Allahabad, Allahabad, India
Oxid Med Cell Longev 2:270-8. 2009
..In the last decade, there has been much interest in the potential health benefits of dietary plant polyphenols as antioxidant...
- Developing a new perspective to study the health of survivors of Sichuan earthquakes in China: a study on the effect of post-earthquake rescue policies on survivors' health-related quality of life
Department of Social Work and Social Policy, School of Social and Behavioral Sciences, Nanjing University, Nanjing 210023, People s Republic of China
Health Res Policy Syst 11:41. 2013
..Therefore, this study develops a new perspective to study the health of earthquake survivors, based on the effect of post-earthquake rescue policies on health-related quality of life (..
- Too much sitting--a health hazard
David W Dunstan
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Diabetes Res Clin Pract 97:368-76. 2012
..involves very low energy expenditure, such as television viewing and desk-bound work) is adversely associated with health outcomes, including cardio-metabolic risk biomarkers, type 2 diabetes and premature mortality...
- The role of nutrition on epigenetic modifications and their implications on health
Josep C Jimenez-Chillaron
Fundació Sant Joan de Déu, Paediatric Hospital Sant Joan de Deu, Spain
Biochimie 94:2242-63. 2012
Nutrition plays a key role in many aspects of health and dietary imbalances are major determinants of chronic diseases including cardiovascular disease, obesity, diabetes and cancer...
- Tackling the wider social determinants of health and health inequalities: evidence from systematic reviews
Department of Geography, Wolfson Research Institute, Durham University Queen s Campus, Stockton on Tees TS17 6BH, UK
J Epidemiol Community Health 64:284-91. 2010
There is increasing pressure to tackle the wider social determinants of health through the implementation of appropriate interventions...
- Insights from past millennia into climatic impacts on human health and survival
Anthony J McMichael
National Centre for Epidemiology and Population Health, Australian National University, Canberra ACT 0200, Australia
Proc Natl Acad Sci U S A 109:4730-7. 2012
Climate change poses threats to human health, safety, and survival via weather extremes and climatic impacts on food yields, fresh water, infectious diseases, conflict, and displacement...
- The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease
Computational Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cell Death Differ 20:1603-14. 2013
..and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding ..
- Defining research to improve health systems
Jan H F Remme
UNICEF UNDP World Bank World Health Organization Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
PLoS Med 7:e1001000. 2010
Robert Terry and colleagues present working definitions of operational research, implementation research, and health systems research within the context of research to strengthen health systems.
- Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
J N Crawley
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
Brain Res 835:18-26. 1999
..Preliminary observations evaluate general health and neurological reflexes. Sensory abilities and motor functions are extensively quantitated...
- Limiting the impact of light pollution on human health, environment and stellar visibility
Istituto di Scienza e Tecnologia dell Inquinamento Luminoso, Via Roma 13, I 36106 Thiene, Italy
J Environ Manage 92:2714-22. 2011
..Here we propose a new way to limit the effects of this residual light pollution on wildlife, human health and stellar visibility...
- An ecological and evolutionary perspective on human-microbe mutualism and disease
Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
Nature 449:811-8. 2007
..fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease...
- Relevance, essentiality and toxicity of trace elements in human health
Cesar G Fraga
Department of Nutrition, University of California, Davis, CA 95616, USA
Mol Aspects Med 26:235-44. 2005
..In humans Mn, Fe, Cu, Zn, and Se accomplish decisive functions to maintain human health. Deficiency in any of these TE leads to undesirable pathological conditions that can be prevented or reversed by ..
- Does positive affect influence health?
Sarah D Pressman
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Psychol Bull 131:925-71. 2005
This review highlights consistent patterns in the literature associating positive affect (PA) and physical health. However, it also raises serious conceptual and methodological reservations...
- Identification and characterization of microRNAs in Clonorchis sinensis of human health significance
Min Jun Xu
Department of Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, PR China
BMC Genomics 11:521. 2010
..sinensis residing chronically in the biliary tract, we developed an integrative approach combining deep sequencing and bioinformatic predictions with stem-loop real-time PCR analysis...
- Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster
Kyu Sun Lee
Aging Research Center, Korean Research Institute of Bioscience and Biotechnology, Daejeon, Korea
Rejuvenation Res 13:561-70. 2010
- Fusobacterium nucleatum in periodontal health and disease
Department of Oral Biology, Faculty of Dental Surgery, University Paul Sabatier, Toulouse, France
Curr Issues Mol Biol 13:25-36. 2011
..Antimicrobial peptides are important contributors to maintaining the balance between health and disease in this complex environment...
- Environmental epigenomics in human health and disease
Dana C Dolinoy
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Environ Mol Mutagen 49:4-8. 2008
- The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease
Department of Immunology, Bruce Rappaport Faculty of Medicine and Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, 1 Efron St, Haifa 31096, Israel
J Leukoc Biol 88:463-73. 2010
..The current review explores the different biological properties of CXCL12 and discusses the implications of CXCL12-based therapies for autoimmunity and cancer diseases...
- Riboflavin (vitamin B-2) and health
Hilary J Powers
Centre for Human Nutrition, The University of Sheffield, United Kingdom
Am J Clin Nutr 77:1352-60. 2003
..This article reviews current evidence that diets low in riboflavin present specific health risks...
- Antioxidants prevent health-promoting effects of physical exercise in humans
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
Proc Natl Acad Sci U S A 106:8665-70. 2009
..Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown...
- Probiotic bacteria induce a 'glow of health'
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 8:e53867. 2013
Radiant skin and hair are universally recognized as indications of good health. However, this 'glow of health' display remains poorly understood...
- Vegetarian diets, low-meat diets and health: a review
Claire T McEvoy
Centre for Public Health, Queen s University Belfast, Institute of Clinical Science B, Belfast, UK
Public Health Nutr 15:2287-94. 2012
To review the epidemiological evidence for vegetarian diets, low-meat dietary patterns and their association with health status in adults.
- Mediterranean diet and health
Department of Clinical and Experimental Medicine, University of Florence, Italy
Biofactors 39:335-42. 2013
..To date, all the major scientific associations as well as the World Health Organization and the nonscientific organizations place an ever-increasing emphasis on the role of diet in ..
- Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 6:e17439. 2011
..However, data on these key parameters are lacking and assumptions are frequently made based on expert opinion. Widely diverse opinions can lead to conflicting outcomes in models they inform...
- Glucocorticoids and the regulation of memory in health and disease
Dominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Front Neuroendocrinol 30:358-70. 2009
..In this context, we review data suggesting that the administration of glucocorticoids might ameliorate chronic anxiety by reducing retrieval of aversive memories and enhancing fear extinction...
- Relationship between vitamin D, parathyroid hormone, and bone health
A J Sai
Bone Metabolism Unit, Department of Medicine, Creighton University Medical Center, 601 North 30 Street, Suite 6718, Omaha, Nebraska 68131, USA
J Clin Endocrinol Metab 96:E436-46. 2011
There is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health.
- Autophagy: a lysosomal degradation pathway with a central role in health and disease
Eeva Liisa Eskelinen
Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, PO Box 56, FIN 00014 Helsinki, Finland
Biochim Biophys Acta 1793:664-73. 2009
..autophagy has been shown to possess important housekeeping and quality control functions that contribute to health and longevity...
- AMPK and the biochemistry of exercise: implications for human health and disease
Erik A Richter
Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, August Krogh Building, 13 Universitetsparken, 2100 Copenhagen, Denmark
Biochem J 418:261-75. 2009
..We also discuss the potential role of AMPK activation in mediating the prevention and treatment by exercise of specific disorders associated with the metabolic syndrome, including Type 2 diabetes and Alzheimer's disease...
- Dynamics of human adipose lipid turnover in health and metabolic disease
Department of Medicine, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
Nature 478:110-3. 2011
..Little is known, however, about adipose lipid turnover in humans in health and pathology...
- Green space, health inequality and pregnancy
Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
Environ Int 40:110-5. 2012
Green spaces have been suggested to improve physical and mental health and well-being by increasing physical activity, reducing air pollution, noise, and ambient temperature, increasing social contacts and relieving psychophysiological ..
- Ecological perspectives in health research
Centre for Health and Policy Studies, G230, Health Sciences Centre, University of Calgary, 3330 Hospital Dr NW, Calgary AB, Canada
J Epidemiol Community Health 59:6-14. 2005
An ecological perspective on health emphasises both individual and contextual systems and the interdependent relations between the two. Origins of this approach have emanated from multiple disciplines over the past century or more...
- The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action
Michael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
Mol Aspects Med 29:361-8. 2008
Vitamin D, the sunshine vitamin, is important for childhood bone health. Over the past two decades, it is now recognized that vitamin D not only is important for calcium metabolism and maintenance of bone health throughout life, but also ..
- Choline and betaine in health and disease
Per Magne Ueland
Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
J Inherit Metab Dis 34:3-15. 2011
..Thus, choline and betaine showed opposite relations with key components of metabolic syndrome, suggesting a disruption of mitochondrial choline oxidation to betaine as part of the mitochondrial dysfunction in metabolic syndrome...
- Cyanobacterial toxins: risk management for health protection
Geoffrey A Codd
Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
Toxicol Appl Pharmacol 203:264-72. 2005
..occurrence and properties of cyanobacterial toxins, with reference to the recognition and management of the human health risks which they may present...
- Change in chronic disability from 1982 to 2004/2005 as measured by long-term changes in function and health in the U.S. elderly population
Kenneth G Manton
Center for Demographic Studies, Duke University, Durham, NC 27708 0408, USA
Proc Natl Acad Sci U S A 103:18374-9. 2006
Changes in the health and functioning of the Medicare-enrolled population aged 65+ are tracked by using the 1982-2004/2005 National Long-Term Care Surveys...
- Calcium pumps in health and disease
Department of Biochemistry, University of Padova, Padova, Italy
Physiol Rev 89:1341-78. 2009
..They do not bring cells to immediate death but seriously compromise their normal functioning...
- Life cycle of connexins in health and disease
Dale W Laird
Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
Biochem J 394:527-43. 2006
..This review will assess the current understanding of wild-type and selected disease-linked mutant connexin transport through the secretory pathway, gap-junction assembly at the cell surface, internalization and degradation...
- Myofibroblasts. I. Paracrine cells important in health and disease
D W Powell
University of Texas Medical Branch at Galveston, Departments of Internal Medicine, Physiology, and Biophysics and Pathology, Galveston, Texas 77555, USA
Am J Physiol 277:C1-9. 1999
..Because of their ubiquitous presence in all tissues, myofibroblasts play important roles in various organ diseases and perhaps in multisystem diseases as well...
- Linking health and health-related information to the ICF: a systematic review of the literature from 2001 to 2008
School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada
Disabil Rehabil 33:1941-51. 2011
In 1976, the World Health Organization (WHO) estimated worldwide disability prevalence at 10%; recent evidence suggests the prevalence is even higher...
- Cell death in health and disease
Richard A Lockshin
Department of Biological Sciences, St John s University, Queens, NY 11439, USA
J Cell Mol Med 11:1214-24. 2007
..In the future, the challenge will be more to understand the challenge to the cell from a more global standpoint, including many more aspects of metabolism, and work toward alleviating or provoking the challenge in a targeted fashion...
- Nutrigenomics: exploiting systems biology in the nutrition and health arenas
Ben van Ommen
TNO Nutrition and Food Research, Zeist, The Netherlands
Nutrition 20:4-8. 2004
- Mannose phosphorylation in health and disease
Department of Biochemistry, Children s Hospital, University Medical Center Hamburg Eppendorf, Research Campus, Martinistrasse 52, 20246 Hamburg, Germany
Eur J Cell Biol 89:117-23. 2010
- Molecular biology of K(ATP) channels and implications for health and disease
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
IUBMB Life 61:971-8. 2009
..Continuing studies of channel physiology and pathology will bring new insights to the molecular basis of K(ATP) channel function, leading to a better understanding of the role that K(ATP) channels play in both health and disease.
- The role of polyphenolic antioxidants in health, disease, and aging
Mark E Obrenovich
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Rejuvenation Res 13:631-43. 2010
..On the other hand, questions still remain as to whether some antioxidants could be potentially harmful to health, because an increase in glycation-mediated protein damage (carbonyl stress) has been reported in some cases...
- Simultaneously mitigating near-term climate change and improving human health and food security
NASA Goddard Institute for Space Studies and Columbia Earth Institute, Columbia University, New York, NY 10025, USA
Science 335:183-9. 2012
..The selected controls target different sources and influence climate on shorter time scales than those of carbon dioxide-reduction measures. Implementing both substantially reduces the risks of crossing the 2°C threshold...
- mTOR Signalling in Health and Disease
Christopher G Proud
School of Biological Sciences, Life Sciences Building, University of Southampton, Southampton SO17 1BJ, UK
Biochem Soc Trans 39:431-6. 2011
- Diet induced epigenetic changes and their implications for health
J A McKay
Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Acta Physiol (Oxf) 202:103-18. 2011
Dietary exposures can have consequences for health years or decades later and this raises questions about the mechanisms through which such exposures are 'remembered' and how they result in altered disease risk...
- Politics and health outcomes
Johns Hopkins University, USA
Lancet 368:1033-7. 2006
The aim of this study was to examine the complex interactions between political traditions, policies, and public health outcomes, and to find out whether different political traditions have been associated with systematic patterns in ..
- Race and sex effects on the association between muscle strength, soft tissue, and bone mineral density in healthy elders: the Health, Aging, and Body Composition Study
D R Taaffe
Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
J Bone Miner Res 16:1343-52. 2001
..and whole body bone mineral density (BMD) in a cohort of 2,619 well-functioning older adults participating in the Health, Aging, and Body Composition (Health ABC) Study with complete measures...
- Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007
Iranian Institute for Health Sciences Research, Tehran, Iran
J Exp Clin Cancer Res 27:32. 2008
..Quality of life in patients with breast cancer is an important outcome. This paper presents an extensive overview on the topic ranging from descriptive findings to clinical trials...
- Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
Center for the Environmental Implications of NanoTechnology CEINT, Duke University, 121 Hudson Hall, Durham, North Carolina 27707, USA
Nat Nanotechnol 4:634-41. 2009
..criterion in any definition of nanoparticles when making decisions about their regulation for environmental, health and safety reasons...
- Money, schooling, and health: Mechanisms and causal evidence
Department of Society, Human Development and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
Ann N Y Acad Sci 1186:56-68. 2010
An association between higher educational attainment and better health status has been repeatedly reported in the literature. Similarly, thousands of studies have found a relationship between higher income and better health...
- Developmental plasticity and human health
Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, UK
Nature 430:419-21. 2004
..however, rapid improvements in nutrition and other environmental conditions may have damaging effects on the health of those people whose parents and grandparents lived in impoverished conditions...
- Personality and the perception of health and happiness
C Robert Cloninger
Dept of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
J Affect Disord 128:24-32. 2011
b>Health is a state of physical, mental, and social well-being...
- Disintegrins in health and disease
Mary Ann McLane
Department of Medical Technology, University of Delaware, 305G Willard Hall Education Building, Newark, DE 19716, USA
Front Biosci 13:6617-37. 2008
..This review will summarize disintegrin investigations since 2003...
- The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
The Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
Cell Death Differ 13:712-29. 2006
..Indeed, further delineating the mechanisms by which NF-kappaB promotes cell survival might hold the key to developing new highly effective therapies for treatment of widespread human diseases...
- Nitric oxide in health and disease of the respiratory system
Fabio L M Ricciardolo
Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
Physiol Rev 84:731-65. 2004
- Keratins in health and cancer: more than mere epithelial cell markers
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
Oncogene 30:127-38. 2011
- Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states
Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20057, USA
Mol Cell Endocrinol 327:1-12. 2010
..The results described here provide evidence that the PKCepsilon-ERK1/2-AP-1/STAT3 signal transduction pathway is the primary regulator of Tspo gene expression in normal and pathological tissues expressing high levels of TSPO...
- OMICS-driven biomarker discovery in nutrition and health
BioAnalytical Science Department, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
J Biotechnol 124:758-87. 2006
..nutrition research has dealt with providing nutrients to nourish populations, it nowadays focuses on improving health of individuals through diet...
- Dietary factors, hormesis and health
Mark P Mattson
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
Ageing Res Rev 7:43-8. 2008
The impact of dietary factors on health and longevity is increasingly appreciated. The most prominent dietary factor that affects the risk of many different chronic diseases is energy intake -- excessive calorie intake increases the risk...