comorbidity

Summary

Summary: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.

Top Publications

  1. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
  2. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
  3. ncbi Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
    Hude Quan
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Med Care 43:1130-9. 2005
  4. ncbi The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    JAMA 289:3095-105. 2003
  5. ncbi Comorbidity measures for use with administrative data
    A Elixhauser
    MEDTAP International, Inc, Bethesda, MD 20814, USA
    Med Care 36:8-27. 1998
  6. ncbi Depression, chronic diseases, and decrements in health: results from the World Health Surveys
    Saba Moussavi
    Department of Measurement and Health Information Systems, World Health Organization, Geneva, Switzerland
    Lancet 370:851-8. 2007
  7. ncbi Aging with multimorbidity: a systematic review of the literature
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm University, Sweden
    Ageing Res Rev 10:430-9. 2011
  8. ncbi Systemic manifestations and comorbidities of COPD
    P J Barnes
    National Heart and Lung Institute, Imperial College, London, UK
    Eur Respir J 33:1165-85. 2009
  9. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  10. pmc A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology
    Martin Fortin
    Department of Family Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Ann Fam Med 10:142-51. 2012

Detail Information

Publications288 found, 100 shown here

  1. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
    ..Little is known about lifetime prevalence or age of onset of DSM-IV disorders...
  2. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    ..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
  3. ncbi Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
    Hude Quan
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Med Care 43:1130-9. 2005
    ..Recognizing this, we conducted a multistep process to develop ICD-10 coding algorithms to define Charlson and Elixhauser comorbidities in administrative data and assess the performance of the resulting algorithms...
  4. ncbi The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    JAMA 289:3095-105. 2003
    ..Uncertainties exist about prevalence and correlates of major depressive disorder (MDD)...
  5. ncbi Comorbidity measures for use with administrative data
    A Elixhauser
    MEDTAP International, Inc, Bethesda, MD 20814, USA
    Med Care 36:8-27. 1998
    This study attempts to develop a comprehensive set of comorbidity measures for use with large administrative inpatient datasets.
  6. ncbi Depression, chronic diseases, and decrements in health: results from the World Health Surveys
    Saba Moussavi
    Department of Measurement and Health Information Systems, World Health Organization, Geneva, Switzerland
    Lancet 370:851-8. 2007
    ..Depression is often comorbid with other chronic diseases and can worsen their associated health outcomes. Few studies have explored the effect of depression, alone or as a comorbidity, on overall health status.
  7. ncbi Aging with multimorbidity: a systematic review of the literature
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm University, Sweden
    Ageing Res Rev 10:430-9. 2011
    ..New insights in this field can lead to the identification of preventive strategies and better treatment of multimorbid patients...
  8. ncbi Systemic manifestations and comorbidities of COPD
    P J Barnes
    National Heart and Lung Institute, Imperial College, London, UK
    Eur Respir J 33:1165-85. 2009
    ..Another approach is the reversal of corticosteroid resistance, for example with effective antioxidants. More research is needed on COPD comorbidities and their treatment...
  9. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  10. pmc A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology
    Martin Fortin
    Department of Family Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Ann Fam Med 10:142-51. 2012
    ..We sought to identify and compare studies reporting the prevalence of multimorbidity and to suggest methodologic aspects to be considered in the conduct of such studies...
  11. ncbi Bariatric surgery: a systematic review and meta-analysis
    Henry Buchwald
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 292:1724-37. 2004
    ..About 5% of the US population is morbidly obese. This disease remains largely refractory to diet and drug therapy, but generally responds well to bariatric surgery...
  12. pmc The predictive value of ICD-10 diagnostic coding used to assess Charlson comorbidity index conditions in the population-based Danish National Registry of Patients
    Sandra K Thygesen
    Department of Clinical Epidemiology, The Institute of Clinical Medicine, Aarhus University Hospital, Denmark
    BMC Med Res Methodol 11:83. 2011
    The Charlson comorbidity index is often used to control for confounding in research based on medical databases. There are few studies of the accuracy of the codes obtained from these databases...
  13. ncbi Prevalence, expenditures, and complications of multiple chronic conditions in the elderly
    Jennifer L Wolff
    Department of Health Policy and Management, The Johns Hopkins University Bloomberg School of Public Health, 624 N Broadway, Room 304, Baltimore, MD 21205, USA
    Arch Intern Med 162:2269-76. 2002
    ..The prevalence, health care expenditures, and hospitalization experiences are important considerations among elderly populations with multiple chronic conditions...
  14. pmc Defining comorbidity: implications for understanding health and health services
    Jose M Valderas
    National Institute for Health Research School for Primary Care Research, The University of Manchester, Manchester, United Kingdom
    Ann Fam Med 7:357-63. 2009
    b>Comorbidity is associated with worse health outcomes, more complex clinical management, and increased health care costs...
  15. pmc The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:716-23. 2006
    ..Despite growing interest in adult attention deficit hyperactivity disorder (ADHD), little is known about its prevalence or correlates...
  16. pmc Depression and type 2 diabetes over the lifespan: a meta-analysis
    Briana Mezuk
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 31:2383-90. 2008
    ..This systematic review examines the bi-directional prospective relationships between depression and type 2 diabetes...
  17. pmc Prevalence of multimorbidity among adults seen in family practice
    Martin Fortin
    Department of Family Medicine, Sherbrooke University, Quebec, Canada
    Ann Fam Med 3:223-8. 2005
    ....
  18. pmc Multimorbidity and comorbidity in the Dutch population - data from general practices
    Sandra H van Oostrom
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven 3720 BA, The Netherlands
    BMC Public Health 12:715. 2012
    ..The objective of this study was to present an overview of the prevalence of multimorbidity and comorbidity of chronic diseases in the Dutch population and to explore disease clustering and common comorbidities.
  19. ncbi Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection
    Kurt Kroenke
    Regenstrief Institute for Health Care and Indiana University, Indianapolis, Indiana 46202, USA
    Ann Intern Med 146:317-25. 2007
    ..Anxiety, although as common as depression, has received less attention and is often undetected and undertreated...
  20. ncbi Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance
    Cynthia M Boyd
    Division of Geriatric Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 294:716-24. 2005
    ..Clinical practice guidelines (CPGs) have been developed to improve the quality of health care for many chronic conditions. Pay-for-performance initiatives assess physician adherence to interventions that may reflect CPG recommendations...
  21. ncbi Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    Douglas S Keith
    Division of Nephrology and Hypertension, Oregon Health and Science University, USA
    Arch Intern Med 164:659-63. 2004
    ..The purpose of this study was to understand the natural history of chronic kidney disease with regard to progression to renal replacement therapy (transplant or dialysis) and death in a representative patient population...
  22. ncbi The prevalence of multimorbidity in primary care and its effect on health care utilization and cost
    Liam G Glynn
    Department of General Practice, National University of Ireland, Galway, Ireland
    Fam Pract 28:516-23. 2011
    ..Multimorbidity is common among the heterogeneous primary care population, but little data exist on its association with health care utilization or cost...
  23. ncbi Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    Linda P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 59:255-63. 2004
    Three terms are commonly used interchangeably to identify vulnerable older adults: comorbidity, or multiple chronic conditions, frailty, and disability...
  24. ncbi Depression and pain comorbidity: a literature review
    Matthew J Bair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Arch Intern Med 163:2433-45. 2003
    ..together, we conducted a literature review to determine the prevalence of both conditions and the effects of comorbidity on diagnosis, clinical outcomes, and treatment...
  25. ncbi Smoking and mental illness: A population-based prevalence study
    K Lasser
    Department of Medicine, Cambridge Hospital, Macht Bldg, 1493 Cambridge St, Cambridge, MA 02139, USA
    JAMA 284:2606-10. 2000
    ..However, recent population-based, nationally representative data are lacking...
  26. ncbi Causes and consequences of comorbidity: a review
    R Gijsen
    National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    J Clin Epidemiol 54:661-74. 2001
    ..search was carried out to identify and summarize the existing information on causes and consequences of comorbidity of chronic somatic diseases. A selection of 82 articles met our inclusion criteria...
  27. ncbi The ESSENCE in child psychiatry: Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations
    Christopher Gillberg
    Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, University of Goteborg, Sweden
    Res Dev Disabil 31:1543-51. 2010
    ..disorder, and autism spectrum disorder--and sharing of symptoms across disorders (sometimes referred to as comorbidity) is the rule rather than the exception in child psychiatry and developmental medicine...
  28. pmc Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study
    Chris Salisbury
    Department of Community Medicine, University of Bristol, UK
    Br J Gen Pract 61:e12-21. 2011
    ..In developed countries, primary health care increasingly involves the care of patients with multiple chronic conditions, referred to as multimorbidity...
  29. ncbi Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:629-40. 2005
    ..Dramatic changes have occurred in mental health treatments during the past decade. Data on recent treatment patterns are needed to estimate the unmet need for services...
  30. pmc Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany
    Hendrik van den Bussche
    Department of Primary Medical Care, Center of Psychosocial Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Public Health 11:101. 2011
    ..This is the first comprehensive study addressing multimorbidity on the basis of German claims data. The main research question was to find out which chronic diseases and disease combinations are specific to multimorbidity in the elderly...
  31. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  32. ncbi The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 167:1357-63. 2010
    ..Population-based studies of the heritability of other neuropsychiatric disorders and comorbidities among them have also been sparse. The authors sought to address both of these issues...
  33. pmc The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication
    James I Hudson
    Department of Psychiatry, Harvard Medical School and Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 61:348-58. 2007
    ..Little population-based data exist on the prevalence or correlates of eating disorders...
  34. ncbi Comorbidity profiles among patients with ankylosing spondylitis: a nationwide population-based study
    Jiunn Horng Kang
    Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan
    Ann Rheum Dis 69:1165-8. 2010
    ..This study aimed to analyse the prevalence and risk of medical comorbidities in patients with AS compared with the general population...
  35. pmc Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions
    Ingmar Schafer
    Department of Primary Medical Care, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 5:e15941. 2010
    ..The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity.
  36. ncbi Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Circulation 110:738-43. 2004
    ..Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely...
  37. ncbi Evidence suggesting that a chronic disease self-management program can improve health status while reducing hospitalization: a randomized trial
    K R Lorig
    Stanford University School of Medicine, California, USA
    Med Care 37:5-14. 1999
    ..It also explored the differential effectiveness of the intervention for subjects with specific diseases and comorbidities...
  38. ncbi Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data
    S Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 154:854-64. 2001
    b>Comorbidity is an important confounder in epidemiologic studies. The authors compared the predictive performance of comorbidity scores for use in epidemiologic research with administrative databases...
  39. pmc Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs
    Christine Vogeli
    Institute for Health Policy in the Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Gen Intern Med 22:391-5. 2007
    ....
  40. ncbi The association of depression and anxiety with medical symptom burden in patients with chronic medical illness
    Wayne Katon
    Department of Psychiatry, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Gen Hosp Psychiatry 29:147-55. 2007
    Primary care patients with anxiety and depression often describe multiple physical symptoms, but no systematic review has studied the effect of anxiety and depressive comorbidity in patients with chronic medical illnesses.
  41. pmc Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden
    Alessandra Marengoni
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Am J Public Health 98:1198-200. 2008
    ..Multimorbidity is the most common clinical picture of the elderly and may be increased by unhealthy behaviors linked to education...
  42. ncbi The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Int J Methods Psychiatr Res 13:93-121. 2004
    ..Elaborate CD-ROM-based training materials are available to teach interviewers how to administer the interview as well as to teach supervisors how to monitor the quality of data collection...
  43. ncbi Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis
    Jurgen Barth
    Department of Rehabilitation Psychology, Institute of Psychology, University of Freiburg, Germany
    Psychosom Med 66:802-13. 2004
    ..The relative risk in meta-analytic aggregation is 1.64 (confidence interval [CI], 1.29-2.08) for any CHD event. However, the adverse impact of depression on CHD patients has not yet been the subject of a meta-analysis...
  44. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
    ..Forty percent had inadequate management of their pain. Interesting differences between countries were observed, possibly reflecting differences in cultural background and local traditions in managing chronic pain...
  45. ncbi Size and burden of mental disorders in Europe--a critical review and appraisal of 27 studies
    Hans Ulrich Wittchen
    Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 15:357-76. 2005
    ..Taking into account the considerable degree of comorbidity (about one third had more than one disorder), the most frequent disorders are anxiety disorders, depressive, ..
  46. ncbi Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    Giorgio Bedogni
    Centro Studi Fegato, Area Science Park, Basovizza, and Department of BBCM, University of Trieste, Italy
    Hepatology 42:44-52. 2005
    ..In conclusion, NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome...
  47. ncbi Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    ....
  48. ncbi Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS)
    F Jacobi
    Institute of Clinical Psychology and Psychotherapy, Unit Epidemiology and Service Research, Technical University of Dresden, Germany
    Psychol Med 34:597-611. 2004
    ..This paper reports results from its Mental Health Supplement (GHS-MHS) on 4-week 12-month, and selected lifetime prevalence of a broad range of DSM-IV mental disorders, their co-morbidity and correlates in the community...
  49. ncbi Validation of diagnostic codes within medical services claims
    Machelle Wilchesky
    Department of Epidemiology and Biostatistics, McGill University, Morrice House, 1140 Pine Avenue West, Montreal, QCH3A 1A3, Canada
    J Clin Epidemiol 57:131-41. 2004
    ..and specificity of medical services claims diagnoses for surveillance of 14 drug disease contraindications used in drug utilization review, the Charlson comorbidity index and the Johns Hopkins Adjusted Care Group Case-Mix profile (ADGs).
  50. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  51. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
    ..We report the development and evaluation of GFR-estimating equations using serum cystatin C alone and serum cystatin C, serum creatinine, or both with demographic variables...
  52. ncbi Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Am Acad Child Adolesc Psychiatry 47:921-9. 2008
    ..We identify the rates and type of psychiatric comorbidity associated with ASDs and explore the associations with variables identified as risk factors for child ..
  53. ncbi Complex chronic comorbidities of COPD
    L M Fabbri
    Dept of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Eur Respir J 31:204-12. 2008
    ..g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity...
  54. pmc 25 year trends in first time hospitalisation for acute myocardial infarction, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity: a Danish nationwide cohort study
    Morten Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    BMJ 344:e356. 2012
    To examine 25 year trends in first time hospitalisation for acute myocardial infarction in Denmark, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity.
  55. ncbi Mortality in COPD: Role of comorbidities
    D D Sin
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Respir J 28:1245-57. 2006
    ..e. inflammation), and the tools used to predict chronic obstructive pulmonary disease mortality...
  56. ncbi Prevalence of depressive symptoms in patients with chronic obstructive pulmonary disease: a systematic review, meta-analysis and meta-regression
    Melvyn W B Zhang
    Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Gen Hosp Psychiatry 33:217-23. 2011
    ....
  57. ncbi Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 22:147-58. 2008
    ..More generally, HIV care and treatment services represent an important venue to identify and manage individuals with common mental disorders in resource-limited settings...
  58. ncbi Systemic manifestations of COPD
    Yvonne Nussbaumer-Ochsner
    Department of Pulmonology, Leiden University Medical Center, C3 P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Chest 139:165-73. 2011
    ..The treatment of COPD is no longer focused exclusively on inhaled therapy but is taking on a multidimensional approach, especially because the treatment of the comorbidities might positively affect the course of COPD itself...
  59. pmc Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication--Adolescent Supplement (NCS-A)
    Kathleen Ries Merikangas
    Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 49:980-9. 2010
    To present estimates of the lifetime prevalence of DSM-IV mental disorders with and without severe impairment, their comorbidity across broad classes of disorder, and their sociodemographic correlates.
  60. ncbi Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis
    Joost P van Melle
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, P O Box 30 001, 9700 RB, The Netherlands
    Psychosom Med 66:814-22. 2004
    ..To assess the association of depression following myocardial infarction (MI) and cardiovascular prognosis...
  61. pmc Prevalence estimates of multimorbidity: a comparative study of two sources
    Martin Fortin
    Department of Family Medicine, Sherbrooke University, Sherbrooke, Quebec, Canada
    BMC Health Serv Res 10:111. 2010
    ..The objective of this study was to compare prevalence estimates of multimorbidity derived from two sources and to examine the impact of the number of diagnoses considered in the measurement of multimorbidity...
  62. ncbi Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)
    Kirkwood F Adams
    Division of Cardiology, University of North Carolina, Chapel Hill, NC, USA
    Am Heart J 149:209-16. 2005
    ..Most available data on these patients are limited by patient selection criteria and study design of clinical trials and single-center studies...
  63. pmc The growing burden of chronic disease in America
    Gerard Anderson
    Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Public Health Rep 119:263-70. 2004
  64. ncbi Risk factors for depression among elderly community subjects: a systematic review and meta-analysis
    Martin G Cole
    Department of Psychiatry, St Mary s Hospital and McGill University, Quebeck, Canada
    Am J Psychiatry 160:1147-56. 2003
    ..The goal of this study was to determine risk factors for depression among elderly community subjects...
  65. ncbi The impact of comorbid chronic conditions on diabetes care
    John D Piette
    Center for Practice Management and Outcomes Research, VA Ann Arbor Health Care System, P O Box 130170, Ann Arbor, MI 48113 0170, USA
    Diabetes Care 29:725-31. 2006
  66. pmc Multimorbidity's many challenges
    Martin Fortin
    BMJ 334:1016-7. 2007
  67. ncbi Prevalence and patterns of multimorbidity in Australia
    Helena C Britt
    Family Medicine Research Centre, School of Public Health, University of Sydney, Sydney, NSW, Australia
    Med J Aust 189:72-7. 2008
    ..To estimate the prevalence and patterns of multimorbidity in a sample of patients attending general practice, in the population who attended general practice in 2005, and in the Australian population...
  68. ncbi Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV
    B Williams
    Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, UK
    J Hum Hypertens 18:139-85. 2004
  69. ncbi Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project
    Jordi Alonso
    Health Services Research Unit, Institut Municipal d Investigacio Medica IMIM IMAS, Barcelona, Spain
    Qual Life Res 13:283-98. 2004
    ..Few studies and no international comparisons have examined the impact of multiple chronic conditions on populations using a comprehensive health-related quality of life (HRQL) questionnaire...
  70. pmc Measures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guide
    Alyson L Huntley
    Academic Unit of Primary Health Care, School of Social and Community Medicine, Bristol University, Bristol, England
    Ann Fam Med 10:134-41. 2012
    ....
  71. pmc Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis
    Bethany B Barone
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    JAMA 300:2754-64. 2008
    ..Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear...
  72. ncbi An improved comorbidity index for outcome analyses among dialysis patients
    Jiannong Liu
    United States Renal Data System Coordinating Center, 914 South 8th Street, Minneapolis, MN 55404, USA
    Kidney Int 77:141-51. 2010
    ..among patients with end-stage renal disease, indexes measuring them have been widely used to describe the comorbidity burden and to predict outcomes as well as adjust for their roles as confounders...
  73. ncbi The disease burden associated with overweight and obesity
    A Must
    Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    JAMA 282:1523-9. 1999
    ..Overweight and obesity are increasing dramatically in the United States and most likely contribute substantially to the burden of chronic health conditions...
  74. pmc Descriptions of barriers to self-care by persons with comorbid chronic diseases
    Elizabeth A Bayliss
    Department of Family Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Fam Med 1:15-21. 2003
    ..Successful management of chronic conditions depends on adequate self-care. However, little is known about the self-care strategies of patients with comorbid chronic conditions...
  75. ncbi New ICD-10 version of the Charlson comorbidity index predicted in-hospital mortality
    Vijaya Sundararajan
    Victorian Department of Human Services, Level 18, 120 Spencer Street, Melbourne, 3000 Victoria, Australia
    J Clin Epidemiol 57:1288-94. 2004
    The ICD-9-CM adaptation of the Charlson comorbidity score has been a valuable resource for health services researchers...
  76. pmc Diabetes treatment patterns and goal achievement in primary diabetes care (DiaRegis) - study protocol and patient characteristics at baseline
    Peter Bramlage
    Institute for Cardiovascular Pharmacology and Epidemiology, Mahlow, Germany
    Cardiovasc Diabetol 9:53. 2010
    ..Data from clinical practice with respect to this patient group are however scarce. Therefore we set up a registry in primary care documenting the course and outcomes of this patient group...
  77. pmc Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide risk
    Maurizio Pompili
    Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, 1035 Via di Grottarossa, Rome 00189, Italy
    J Headache Pain 10:283-90. 2009
    ..The increase in self-efficacy and mental health associated with pharmaceutical care may be instrumental in improving the long-term pharmacotherapy of patients with migraine and headache...
  78. ncbi Prevalence of morbidity and multimorbidity in elderly male populations and their impact on 10-year all-cause mortality: The FINE study (Finland, Italy, Netherlands, Elderly)
    A Menotti
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Epidemiol 54:680-6. 2001
    ..In these elderly men prevalent morbidity and comorbidity was relatively common and it explained a large proportion of excess in all-cause mortality in 10 years of ..
  79. pmc Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication
    Jules Angst
    Department of Psychiatry, Zurich University Psychiatric Hospital, Zurich, Switzerland
    Am J Psychiatry 167:1194-201. 2010
    ..The authors examined the prevalence and clinical correlates of major depressive disorder with subthreshold bipolarity compared with pure major depressive disorder in the National Comorbidity Survey Replication (NCS-R).
  80. pmc Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study
    Arti Hurria
    City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA 91010, USA
    J Clin Oncol 29:3457-65. 2011
    ..The goals of this study are to identify risk factors for chemotherapy toxicity in older adults and develop a risk stratification schema for chemotherapy toxicity...
  81. ncbi Patterns of comorbidities in newly diagnosed COPD and asthma in primary care
    Joan B Soriano
    Worldwide Epidemiology and Global Clinical Safety and Pharmacovigilance, GlaxoSithKline R and D, Upper Providence, PA, USA
    Chest 128:2099-107. 2005
    ..We aimed to quantify baseline rates of comorbidities in COPD and asthma patients and to compare the risks to the general population...
  82. ncbi Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria
    C R Soldatos
    Sleep Research Unit, Department of Psychiatry, Athens University Medical School, Athens, Greece
    J Psychosom Res 48:555-60. 2000
    ..To describe and validate the Athens Insomnia Scale (AIS)...
  83. ncbi Predicting the outcome of total knee arthroplasty
    Elizabeth A Lingard
    Brigham and Women s Hospital, 75 FrancisStreet, Boston, MA 02115, USA
    J Bone Joint Surg Am 86:2179-86. 2004
    ..This paper examines the preoperative predictors of pain and functional outcome at one and two years following total knee arthroplasty...
  84. ncbi Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA)
    Femke Lamers
    Department of Psychiatry EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Psychiatry 72:341-8. 2011
    b>Comorbidity of depressive and anxiety disorders is common and has been shown to be a consistent predictor of chronicity. Comorbidity patterns among specific depressive and anxiety disorders have not been extensively reported...
  85. ncbi Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status
    Dina Zekry
    Geneva University, Rehabilitation and Geriatrics Department, 3, chemin du Pont Bochet, CH 1226, Thonex, Switzerland
    Age Ageing 37:83-9. 2008
    ..demented patients have been reported to be healthier than other old people of the same age...
  86. ncbi Epidemiology of viral hepatitis and HIV co-infection
    Miriam J Alter
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Mailstop D 66, Atlanta, GA 30333, USA
    J Hepatol 44:S6-9. 2006
    ....
  87. pmc Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders
    Jennifer Greif Green
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 67:113-23. 2010
    ..Because CAs are highly clustered, this approach results in overestimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models...
  88. pmc The impact of cellular networks on disease comorbidity
    Juyong Park
    Department of Physics, Biology, and Computer Science, Center for Complex Network Research, Northeastern University, Boston, MA 02115, USA
    Mol Syst Biol 5:262. 2009
    ..interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects...
  89. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  90. ncbi The development of a comorbidity index with physical function as the outcome
    Dianne L Groll
    Department of Surgery, Queen s University, Kingston, Ontario, Canada
    J Clin Epidemiol 58:595-602. 2005
    ..The objective of this study was to develop a self-administered Functional Comorbidity Index with physical function as the outcome.
  91. ncbi Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients
    Suellen M Curkendall
    Cerner Health Insights, Vienna, VA 22182, USA
    Ann Epidemiol 16:63-70. 2006
    ..To measure prevalence, incidence, and mortality of cardiovascular outcomes among persons with chronic obstructive pulmonary disease (COPD) and to assess the extent these outcomes differ from persons without COPD...
  92. ncbi Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999
    Robert N Foley
    United States Renal Data System Coordinating Center, 914 South 8th Street, Suite D 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:489-95. 2005
    ..On an absolute basis, however, the high death rates of patients with CKD may reflect accelerated rates of atherosclerotic vascular disease and congestive heart failure...
  93. ncbi Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care
    Johanna R Feary
    Division of Epidemiology and Public Health, University of Nottingham, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Thorax 65:956-62. 2010
    ..A study was undertaken to quantify the burden of comorbidity and to determine the risk of first acute arteriovascular events among individuals with COPD.
  94. ncbi Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers
    D C Buse
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Neurol Neurosurg Psychiatry 81:428-32. 2010
    ..To characterise and compare the sociodemographic profiles and the frequency of common comorbidities for adults with chronic migraine (CM) and episodic migraine (EM) in a large population-based sample...
  95. ncbi Comorbidity and functional status are independent in older cancer patients
    M Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer and Research Institute, University of South Florida, Tampa 33612, USA
    J Clin Oncol 16:1582-7. 1998
    b>Comorbidity is a frequent and often therapeutically limiting problem in older cancer patients. However, to date, there is no standard measure of the comorbidity burden available for these patients...
  96. ncbi Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study
    Henrik Watz
    Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Am J Respir Crit Care Med 177:743-51. 2008
    ..Physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD). COPD has a systemic component that includes significant extrapulmonary effects that may contribute to its severity in individual patients...
  97. pmc Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication
    M K Nock
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Mol Psychiatry 15:868-76. 2010
    ..which disorders that are uniquely associated with suicidal behavior because of high levels of psychiatric comorbidity. We examined the unique associations between individual disorders and subsequent suicidal behavior (suicide ..
  98. pmc Threads and yarns: weaving the tapestry of comorbidity
    Barbara Starfield
    Ann Fam Med 4:101-3. 2006
  99. pmc A dynamic network approach for the study of human phenotypes
    César A Hidalgo
    Center for International Development and Harvard Kennedy School, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 5:e1000353. 2009
    ..The dataset introduced here, released concurrently with this publication, represents the largest relational phenotypic resource publicly available to the research community...
  100. ncbi The impact of comorbidity on surgical outcomes in laparoscopy-assisted distal gastrectomy: a retrospective analysis of multicenter results
    Wook Kim
    Department of Surgery, The Catholic University of Korea, Holy Family Hospital, Gyeonggi Do, Korea
    Ann Surg 248:793-9. 2008
    ..The purpose of this study was to evaluate the impact of comorbidities on the surgical outcomes in laparoscopy-assisted distal gastrectomy (LADG)...
  101. ncbi Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?
    Stephen C L Gough
    Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    J Psychopharmacol 19:47-55. 2005
    ..This article reviews the genetic basis to schizophrenia and type 2 diabetes and discusses the potential for shared loci between both conditions...

Research Grants79

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..of the most interesting cellular signaling pathways involved in the development of obesity and obesity-related comorbidity has been the endocannabinoid (eCB) system...
  3. Signaling Mechanisms in Alcohol Drinking Behaviors
    Subhash C Pandey; Fiscal Year: 2013
    ..However, the epigenetic and signaling mechanisms that may be involved in the comorbidity of anxiety and alcoholism remain unclear...
  4. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    ..from the bedside to the bench with the explicit intent to distinguish and target the mechanisms of secondary comorbidity from those attributable to the primary neuromuscular impairment...
  5. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..For example, central to the clinical problem of PTSD, which has a ~90% comorbidity with major depressive disorder in patients who had early life stress, is the inability of these patients to ..
  6. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Cystic fibrosis related diabetes (CFRD) is the most common comorbidity in Cystic Fibrosis (CF) and it is associated with increased mortality and rapid decline in lung function...
  7. PTSD Hyperarousal Symptoms Treated with Physiological Stress Management
    WALTON THOMPSON ROTH; Fiscal Year: 2011
    ..Attempts to relieve anxiety with alcohol or other substances may be the reason for the high comorbidity between PTSD and alcohol and substance abuse in US combat veterans, although in some studies, substance abuse ..
  8. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..The factors of focus are pain, sleep and depression, rarely considered as a triad of comorbidity. My short-term goal for the duration of this 12-month Career Development Award is to build a substantial ..
  9. Diet, Insulin, Dopamine, and Reward.
    Margaret E Rice; Fiscal Year: 2013
    ..The increasing prevalence of insulin resistance and obesity and the high comorbidity of disordered eating and substance abuse indicate that understanding the connections among diet, insulin, DA ..
  10. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..community at large, MCI is a unstable and heterogeneous entity, particularly in individuals with significant comorbidity. For the concept to be clinically useful, it must have better predictive value for different outcomes...
  11. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..Advancement of knowledge in this area will likely contribute to the development of effective therapy and the improvement of quality of life in those patients who suffer from both epilepsy and depression. ..
  12. Sex Differences in Myocardial Ischemia Triggered by Emotional Factors after MI
    Viola Vaccarino; Fiscal Year: 2010
    ..Reasons for these differences are unknown;they are not explained by traditional CHD risk factors, other comorbidity or treatments, and occur despite the fact that women have less coronary atherosclerosis and more preserved ..
  13. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..of visceral hypersensitivity and the emerging recognition that functional abdominal pain can involve comorbidity of gut hypersensitivity with other pain syndromes elsewhere in the body (e.g...
  14. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    ..and prevention by a) contributing to a literature base that suggests PTSD has a primary causal role in PTSD/AD comorbidity because PTSD is the source of the aversive emotion/arousal which, when dampened by alcohol use, provides the ..
  15. Mental Stress and Myocardial Ischemia after MI: Sex Differences and Mechanisms
    Viola Vaccarino; Fiscal Year: 2013
    ..The reasons for these differences are unknown;they are not explained by traditional risk factors, comorbidity or treatments, and occur despite that women have less coronary atherosclerosis than men...
  16. Longitudinal Studies of Autism Spectrum Disorders: 2 to 23
    Catherine Lord; Fiscal Year: 2012
    ..Study 2 will focus more specifically on psychiatric comorbidity and mood disorders in ASD, as well as the relationship between coping resources, comorbidity and quality of ..
  17. Modulated Imaging in Comprehensive Assessment of Diabetic Foot Ulcer Development
    Amaan Mazhar; Fiscal Year: 2012
    ..Foot ulceration continues to be a major comorbidity of diabetes and afflicts as many as 15 to 25% of subjects with type 1 and 2 during their lifetime...
  18. Developmental Genetic Epidemiology of Smoking
    Hermine H Maes; Fiscal Year: 2013
    ..by applicant): This project aims to increase our understanding of the etiology, development, heterogeneity and comorbidity of smoking by examining both individual and contextual influences...
  19. Gene-Environment Interplay in the Comorbidity of PTSD and Disordered Eating
    Karen S Mitchell; Fiscal Year: 2013
    ..The proposed training plan of my K01 application, The Interplay of Genetic and Environmental Factors in the Comorbidity of PTSD and Disordered Eating, would greatly enhance my predoctoral training in psychology, behavioral genetics,..
  20. Cancer Care among Medicare HIV patients
    Sumedha Chhatre; Fiscal Year: 2011
    ..A control group of Medicare patients, free of any cancer, matched by age, gender, ethnicity and comorbidity will be obtained from the Medicare 5% sample from SEER...
  21. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..This aim will characterize the effects of estradiol on visceral and somatic sensitivity in the comorbidity model and test the hypothesis that the visceral hypersensitivity induced by the comorbid conditions is ..
  22. AIDS, Immune Activation and Mental Health
    Robert Dantzer; Fiscal Year: 2010
    ..The mechanisms underlying the high comorbidity between HIV-1 infection and psychiatric disorders are still elusive...
  23. Genetics of Bone Structure and Metabolism
    Michael C Mahaney; Fiscal Year: 2013
    ..In older persons, osteoporotic fracture is associated with substantial comorbidity and mortality...
  24. Neural mechanisms underlying abnormal food reward processing in depressed women
    LAURA MCGRATH HOLSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The comorbidity between major depressive disorder (MDD) and obesity appears especially strong in and perhaps limited to females, even controlling for demographic variables, as evidenced by ..
  25. Neuroimaging mechanisms of overlap between alcoholism and bipolar disorder
    JAMES JOSEPH PRISCIANDARO; Fiscal Year: 2013
    ..impulsivity (response inhibition), and reward sensitivity (sensitivity to alcohol cues) as contributors to comorbidity between BD and alcohol dependence (AD) using 1H-MRS and fMRI in individuals with co-occurring AD and euthymic ..
  26. Impact of Sleep in the Restoring Insulin Secretion (RISE) Study
    Babak Mokhlesi; Fiscal Year: 2013
    ..In fact, the prevalence of OSA in patients with T2DM ranges between 58 to 86% making it the most common comorbidity in T2DM. It has been estimated that the prevalence of OSA is also very high in prediabetes...
  27. Cortactin and Spine Dysfunction in Fragile X
    RONALD ROBERT SEESE; Fiscal Year: 2013
    ..In models of many autism-associated disorders and conditions with comorbidity for autism, such Fragile X, Rett, and Angelman Syndromes, there are significant abnormalities in dendritic ..
  28. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Susan J Zieman; Fiscal Year: 2012
    ..cohort studies have sufficient numbers of participants, duration, stored specimens, measures of comorbidity, and confirmed outcomes to comprehensively examine these pathways in older adults...
  29. VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ..of the agents, as well as effect modification by age, gender, baseline nutrient levels, baseline medical comorbidity, latitude, and physical activity...
  30. Risk of death among veterans with depression
    Kara Zivin; Fiscal Year: 2013
    ..with death, as well as the impact of potential confounding factors, including medical and psychiatric comorbidity, health behaviors, and sociodemographic characteristics...
  31. The Role of Leptin in Inflammation-driven Bone Loss
    Urszula T Iwaniec; Fiscal Year: 2013
    ..is hypothesized that leptin, by exacerbating pathogenic proinflammatory immune responses, acts as an important comorbidity factor to amplify inflammation-driven bone loss...
  32. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ....
  33. Empirical eating disorder classification and validation using prospective studies
    Nadia Micali; Fiscal Year: 2013
    ..gt;two times per week). We will use comorbidity and outcome (weight gain and weight status, comorbid depression, anxiety, substance and alcohol use, and ..
  34. Cognitive Impairment and Self-management in Adults with Heart Failure
    Joel W Hughes; Fiscal Year: 2013
    ..relationships altered when adjusting for medical, demographics, and psychosocial factors (illness severity, comorbidity, physical, sensory and sleep impairments, previous HF hospitalization;age, gender, ethnicity, SES, education, ..
  35. EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICS
    Mary N Haan; Fiscal Year: 2013
    ..AIM 3.0: Comorbidity is cumulative over time and is simultaneously associated with the multiple outcomes of greater cognitive and ..
  36. Comprehensive vs. Assisted Management of Mood and Pain Symptoms (CAMMPS) Trial
    Kurt Kroenke; Fiscal Year: 2013
    ..Innovation. CAMMPS provides an integrated approach to PAD symptom comorbidity rather than fragmented care of single symptoms;coordinated symptom management in partnership with both primary ..
  37. Epidemiology of Suicidal Behavior in Racially/Ethnically Diverse Older Americans
    AMY LYNN BYERS; Fiscal Year: 2013
    ..The aims will be addressed by studying three nationally representative aggregated data sets: 1) the National Comorbidity Survey Replication (NCS-R), a probability sample of the general U.S...
  38. Acute Coronary Syndrome Outcomes for Medicare Patients
    SALLY STEARNS; Fiscal Year: 2009
    ..over the study period (2002-2006) in Medicare patients presenting with ACS;2) Determine the influence of age, comorbidity presence, race, gender, and geographic location on the selection of mechanical revascularization strategy (PCIS ..
  39. SOCIODEMOGRAPHIC REGULATION OF CV FUNCTION AND STRUCTURE
    Frank A Treiber; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cardiovascular disease (CVD), type 2 diabetes (T2D) and their comorbidity pose important health challenges for the United States in the coming decades...
  40. Health Promotion and Fitness for Younger and Older Adults With SMI
    Stephen J Bartels; Fiscal Year: 2012
    ..illness (SMI) have a 20 percent reduced life expectancy and disproportionately greater prevalence of medical comorbidity associated with high rates of obesity, sedentary lifestyle, and poor dietary and health behaviors...
  41. Challenging and Expanding Paradigms of Aging with HIV
    KERI NICOLE ALTHOFF; Fiscal Year: 2013
    ..risk of comorbidities in HIV-infected and similar -uninfected individuals in the US in clinical care, by age at comorbidity diagnosis...
  42. Accelerated Biological Aging in Schizophrenia
    Gregory A Light; Fiscal Year: 2013
    ..It also is associated with higher medical comorbidity and a 20- to 25-year shorter life span than the general population...
  43. In utero antidepressant exposures and risk for autism
    Roy H Perlis; Fiscal Year: 2013
    ..pharmacovigilance studies, using tools developed by the investigators for characterizing depression severity/comorbidity and course to better match cases and controls...
  44. Glycation as a Mechanism Promoting Cancer Disparity
    DAVID PAUL TURNER; Fiscal Year: 2013
    ..these confounding factors but to analyze racial specific factors promoting disparity in diabetes, cancer and comorbidity for the two diseases...
  45. Improving PTSD Service Delivery for Veterans with Severe Mental Illness
    Anouk L Grubaugh; Fiscal Year: 2013
    ..This is a considerable issue because trauma, PTSD, and psychiatric comorbidity are particularly common among Veterans and such comorbidity clearly exacerbates the overall course and severity ..
  46. A Novel Computational Framework for Individualized Clinical Decision-Making
    Nancy Lan Guo; Fiscal Year: 2013
    ..3, a prognostic categorization scheme will be designed by combining clinical, pathological, demographic, and comorbidity factors using large patient population data retrieved from SEER (Surveillance, Epidemiology, and End Results) ..
  47. Development &Malleability from Childhood to Adulthood
    Nicholas S Ialongo; Fiscal Year: 2013
    ..To use genotypes from blood or buccal/salivary samples to model genetic influences on the onset, course and comorbidity of psychiatric symptoms and disorders and substance use, abuse, and dependence through youth and family ..
  48. Treatment of Functional Impairment in Heart Failure Patients with Depression
    Kenneth E Freedland; Fiscal Year: 2012
    ..non-study antidepressants, severity of depression, severity and chronicity of heart failure, medical comorbidity, use of HF specialty care, and participation in cardiac rehabilitation...
  49. Conduct Disorder &Depression in Girls: Precursors, Development and Comorbidity
    Rolf Loeber; Fiscal Year: 2012
    ..will elucidate precursors to CD and MDD in adolescence, their sub-syndromal phenotypes, common patterns of comorbidity, and risk, promotive and protective factors associated with transitions from precursor, to sub-syndrome, to ..
  50. Population-Based Assessment of Cancer Trial Generalizability in the Elderly
    Elizabeth B Lamont; Fiscal Year: 2012
    ..g., demographics, comorbidity) and providers (e.g., board certification, years in practice)...
  51. Parkinson Disease Disparities and Outcomes
    Allison Wright Willis; Fiscal Year: 2013
    ..The candidate will derive and validate a PD-specific comorbidity index (PDCI)...
  52. Health Risk Behavior in Late Childhood: Impact of Longitudinal Randomized Trial
    STEPHANIE contact JONES; Fiscal Year: 2010
    ..as for girls and boys;and (4) conduct three additional exploratory sets of analyses to (a) examine issues of comorbidity among the four domains using dynamic, continuous latent class modeling, (b) explore the impact of two important ..
  53. Trajectory of Adverse events and Analgesia with Opioids in older adults - TAANGO
    Richard A Deyo; Fiscal Year: 2013
    ..For most of these, the prevalence, time course, and causal role of opioids (as opposed to chronic pain or comorbidity) remain unclear...
  54. Promoting Physical Activity in Older Adults with Comorbidity
    ELIZABETH ANN SCHLENK; Fiscal Year: 2013
    ....
  55. Refining Borderline Personality Disorder Using Flexible Latent Variable Modeling
    MICHAEL NELSON HALLQUIST; Fiscal Year: 2011
    ..This proposed research will be conducted using two major epidemiological datasets (the National Comorbidity Survey Replication and the National Epidemiologic Survey on Alcohol and Related Conditions) and a large sample ..
  56. Personality-Epidemiologic Research on Inequalities in Longevity
    Benjamin P Chapman; Fiscal Year: 2013
    ..personality phenotype, both alone and in conjunction with standard chronic disease components of the Charlson Comorbidity Index, a popular prognostic model for mortality...
  57. Trajectories of Substance Use and Comorbid Mental Illness
    Magdalena Cerda; Fiscal Year: 2013
    ..of psychopathology, and of the factors - from the community to the individual level - that drive patterns of comorbidity. My long-term career goal is to develop the training and experience needed to execute a research agenda that ..
  58. An RCT of CBT-Telephone for Late-Life GAD
    Gretchen A Brenes; Fiscal Year: 2013
    ..baseline anxiety severity, baseline depressive disorders, baseline psychotropic medication use), medical comorbidity, and therapist assignment. Maintenance of response will be assessed over 6 months...
  59. Novel Associations of Anxiety, Depression and Telomeres across Mid- and Late-Life
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ..addressing whether any identified telomere-mental health associations are explained, in part, by medical comorbidity. In summary, this study will conduct hypothesis testing of an innovative clinical translational model in which ..
  60. TRAINING IN THE EPIDEMIOLOGY OF AGING
    Anne B Newman; Fiscal Year: 2013
    ..skills with emphasis on longitudinal and survival analysis, evaluation of heterogeneity and confounding by comorbidity and polypharmacy, assessment of functional health outcomes, and clinical trial methodology in older populations...
  61. Amyloid-RAGE Signaling in Bone Remodeling
    Wen Cheng Xiong; Fiscal Year: 2013
    ..Increasing evidence from clinical and epidemiological studies supports a degree of comorbidity of both disorders...
  62. Technology to Assess Vulnerable Older Adults with Cancer and Their Caregivers
    Arti Hurria; Fiscal Year: 2013
    ..assessment covers factors that predict morbidity and mortality in older adults, including functional status, comorbidity, cognition, psychological state nutritional status, and social support...
  63. PHARMACOLOGY OF ANTICANCER DRUGS IN ADVANCED AGE
    HEINZ LENZ; Fiscal Year: 2003
    ..among patients aged 70 years and older; (c) the feasibility of using standardized self-report measures of comorbidity and functional status in the context of multicenter clinical trials for elderly patients with cancer; (d) at a ..
  64. DISCREPANCIES BETWEEN PATIENT AND PUBLIC UTILITY RATINGS
    Peter Ubel; Fiscal Year: 2004
    ..The measures for all studies include utilities, quality of life, comorbidity, and demographic characteristics...
  65. Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD
    Amit Etkin; Fiscal Year: 2012
    ..The difficulties associated with treatment of PTSD are further compounded by comorbidity with mild traumatic brain injury (mTBI), which is the "signature injury" of the conflicts in Afghanistan and ..
  66. GERIATRIC COMORBIDITY: HOSPITAL COURSE AND COST
    JAMES STRAIN; Fiscal Year: 1991
    The principal aim of ST Award is to describe the impact of coexistent medic l and psychiatric disorders - comorbidity - on geriatric inpatients' length o hospital stay and cost...
  67. Reducing Ethnic and Racial Bias in Screening for Psychiatric Disorders in Adolesc
    Margarita Alegria; Fiscal Year: 2010
    ..This project provides the opportunity to support the analysis and dissemination of data from the National Comorbidity Survey Adolescent Supplement (NCS-A), the most comprehensive national data available to study screening and ..
  68. CBT Treatment of Panic Disorder in Comorbid Alcoholics
    MATT KUSHNER; Fiscal Year: 2003
    ..an increased risk of alcohol use disorder among those suffering with the anxiety syndrome, panic disorder "comorbidity"...
  69. DEVELOPMENT AND VALIDATION OF A HEAD AND NECK CANCER COM
    Jay Piccirillo; Fiscal Year: 2000
    ..The specific aims of this project are: 1. To assess the validity of the Head and Neck Cancer Comorbidity Index (HNCCI), an anatomic site-specific comorbidity index developed by the Investigators from the study of ..
  70. COMORBIDITY AND TREATMENT PATHS FOR INDIAN ADOLESCENTS
    Douglas Novins; Fiscal Year: 1999
    ..The comorbidity of psychiatric disorders and substance abuse among American Indian adolescents is a serious problem...
  71. An Integrative Psychobiological Investigation of Comorbid Depression and Anxiety
    IAN GOTLIB; Fiscal Year: 2009
    ..In recent years it has become increasingly apparent that depression and anxiety are highly comorbid. The comorbidity of Major Depressive Disorder (MDD) and Social Anxiety Disorder (SAD) is particularly pernicious: compared to ..
  72. Chronic Cocaine Exposure & HIV-1 Tat: Dysregulation of the Medical Prefrontal Cor
    Xiu Ti Hu; Fiscal Year: 2010
    ..behaviors, as well as of addiction, the mechanisms underlying its dysregulation in the cocaine abuse-HIV/AIDS comorbidity have not been examined...
  73. Clinical Significance of Blood Pressure in the very old
    Shiva Satish; Fiscal Year: 2002
    ..It has been argued that this observed L-shaped relationship is due to underlying comorbidity leading to both lower blood pressure and increased mortality...
  74. Comorbidity, Costs and Outcomes in Dialysis Patients
    Srinivasan Beddhu; Fiscal Year: 2002
    ..has increased to 60 years and prevalence of comorbid conditions such as diabetes has increased, increasing comorbidity may profoundly impact on morbidity, mortality and costs in the dialysis population...
  75. 2/2-Preventing Eating Disorders and Reducing Comorbidity
    DENISE ELLA WILFLEY; Fiscal Year: 2010
    ..If effective, the enhanced intervention provides an easy and inexpensive method to reduce EDs and ED comorbidity in college-age women PUBLIC HEALTH RELEVANCE: Eating disorders are common and disabling problems among college-..
  76. 1/2-Preventing Eating Disorders and Reducing Comorbidity
    CBARR BARR TAYLOR; Fiscal Year: 2010
    ..If effective, the enhanced intervention provides an easy and inexpensive method to reduce EDs and ED comorbidity in college-age women PUBLIC HEALTH RELEVANCE: Eating disorders are common and disabling problems among college-..
  77. Mental Comorbidity and Chronic Illness in the National Medicaid System
    Benjamin Druss; Fiscal Year: 2009
    ..However, little is known about the impact of mental comorbidity on quality of care for chronic conditions within the Medicaid system, how that association varies across ..
  78. Comorbid Anxiety Disorders in Adolescents with Asthma
    Wayne Katon; Fiscal Year: 2006
    ..adolescents with panic disorder and asthma to those with asthma alone in order to measure the impact of panic comorbidity on the personal, familial and societal impacts of asthma such as symptom burden, functional status, quality of ..
  79. Child Psychopathology, Adversity & Developing Drug Abuse
    BETH MOLNAR; Fiscal Year: 2004
    b>Comorbidity of addictive and mental disorders has been shown to be pervasive, with more than half (54%) of those aged 15-54 in the National Comorbidity Survey who had one diagnosable disorder having at least one co-occurring disorder...