point of care systems


Summary: Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.

Top Publications

  1. ncbi Reliability of point-of-care testing of INR in acute stroke
    Theresa L Green
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm C1101A, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada
    Can J Neurol Sci 35:348-51. 2008
  2. ncbi Evaluation of a rapid bedside toxicology screen in patients suspected of drug toxicity
    Christian Tomaszewski
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    J Emerg Med 28:389-94. 2005
  3. ncbi Dysphagia bedside screening for acute-stroke patients: the Gugging Swallowing Screen
    Michaela Trapl
    Center of Clinical Neurosciences, Danube University, Krems, and the Department of Neurology, Landesklinikum Donauregion, Maria Gugging, Austria
    Stroke 38:2948-52. 2007
  4. pmc Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis
    G J Geersing
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMJ 339:b2990. 2009
  5. ncbi Point-of-care testing for patients with diabetes, hyperlipidaemia or coagulation disorders in the general practice setting: a systematic review
    Angela Gialamas
    Discipline of General Practice, The University of Adelaide, Adelaide, South Australia
    Fam Pract 27:17-24. 2010
  6. ncbi Finding and applying evidence during clinical rounds: the "evidence cart"
    D L Sackett
    Nuffield Department of Clinical Medicine, University of Oxford, England
    JAMA 280:1336-8. 1998
  7. ncbi Ultrasound diagnosis of occult pneumothorax
    Daniel A Lichtenstein
    Medical Intensive Care Unit, Hopital Ambroise Pare, Boulogne Paris Ouest, France
    Crit Care Med 33:1231-8. 2005
  8. ncbi Does point-of-care testing lead to the same or better adherence to medication? A randomised controlled trial: the PoCT in General Practice Trial
    Angela Gialamas
    Discipline of General Practice, University of Adelaide, Adelaide, SA, Australia
    Med J Aust 191:487-91. 2009
  9. pmc Evaluation of "point of care" devices in the measurement of low blood glucose in neonatal practice
    H T Ho
    Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong SAR, China
    Arch Dis Child Fetal Neonatal Ed 89:F356-9. 2004
  10. ncbi Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices
    Michael T Ganter
    Department of Anesthesia and Perioperative Care, University of CA San Francisco, San Francisco, California, USA
    Anesth Analg 106:1366-75. 2008

Research Grants

Detail Information

Publications205 found, 100 shown here

  1. ncbi Reliability of point-of-care testing of INR in acute stroke
    Theresa L Green
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm C1101A, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada
    Can J Neurol Sci 35:348-51. 2008
    ..The objective of this study was to evaluate the reliability, validity, and impact on clinical decision-making of a POCT device for INR testing in the setting of acute ischemic stroke (AIS)...
  2. ncbi Evaluation of a rapid bedside toxicology screen in patients suspected of drug toxicity
    Christian Tomaszewski
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    J Emerg Med 28:389-94. 2005
    ..Further testing will be required to verify the efficacy of the test in populations with a higher prevalence of phencyclidine and amphetamine abuse...
  3. ncbi Dysphagia bedside screening for acute-stroke patients: the Gugging Swallowing Screen
    Michaela Trapl
    Center of Clinical Neurosciences, Danube University, Krems, and the Department of Neurology, Landesklinikum Donauregion, Maria Gugging, Austria
    Stroke 38:2948-52. 2007
    ..The Gugging Swallowing Screen (GUSS) aims at reducing the risk of aspiration during the test to a minimum; it assesses the severity of aspiration risk and recommends a special diet accordingly...
  4. pmc Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis
    G J Geersing
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMJ 339:b2990. 2009
    ..To review the evidence on the diagnostic accuracy of the currently available point of care D-dimer tests for excluding venous thromboembolism...
  5. ncbi Point-of-care testing for patients with diabetes, hyperlipidaemia or coagulation disorders in the general practice setting: a systematic review
    Angela Gialamas
    Discipline of General Practice, The University of Adelaide, Adelaide, South Australia
    Fam Pract 27:17-24. 2010
    ..Point-of-care testing (PoCT) is increasingly being used in the general practice setting and has the potential to provide improved health outcomes for patients...
  6. ncbi Finding and applying evidence during clinical rounds: the "evidence cart"
    D L Sackett
    Nuffield Department of Clinical Medicine, University of Oxford, England
    JAMA 280:1336-8. 1998
    ..Physicians need easy access to evidence for clinical decisions while they care for patients but, to our knowledge, no investigators have assessed use of evidence during rounds with house staff...
  7. ncbi Ultrasound diagnosis of occult pneumothorax
    Daniel A Lichtenstein
    Medical Intensive Care Unit, Hopital Ambroise Pare, Boulogne Paris Ouest, France
    Crit Care Med 33:1231-8. 2005
    ..Pneumothorax can be missed by bedside radiography, and computed tomography is the current alternative. We asked whether lung ultrasound could be of any help in this situation...
  8. ncbi Does point-of-care testing lead to the same or better adherence to medication? A randomised controlled trial: the PoCT in General Practice Trial
    Angela Gialamas
    Discipline of General Practice, University of Adelaide, Adelaide, SA, Australia
    Med J Aust 191:487-91. 2009
    ..To compare the clinical effectiveness of point-of-care testing (PoCT) with that of pathology laboratory testing, as measured by patients' adherence to medication...
  9. pmc Evaluation of "point of care" devices in the measurement of low blood glucose in neonatal practice
    H T Ho
    Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong SAR, China
    Arch Dis Child Fetal Neonatal Ed 89:F356-9. 2004
    ..Low blood glucose in newborns is difficult to detect clinically. Hence a reliable "point of care" device (glucometer) for early detection and treatment of low glucose is needed...
  10. ncbi Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices
    Michael T Ganter
    Department of Anesthesia and Perioperative Care, University of CA San Francisco, San Francisco, California, USA
    Anesth Analg 106:1366-75. 2008
    ..To ensure optimal accuracy and performance, standardized procedures for blood sampling and handling, strict quality controls and trained personnel are required...
  11. ncbi Hand-held thoracic sonography for detecting post-traumatic pneumothoraces: the Extended Focused Assessment with Sonography for Trauma (EFAST)
    A W Kirkpatrick
    Department of Critical Care Medicine, Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 57:288-95. 2004
    ..However, the diagnostic utility of hand-held US has not been previously evaluated in this role...
  12. ncbi Diagnostic accuracy of a bedside D-dimer assay and alveolar dead-space measurement for rapid exclusion of pulmonary embolism: a multicenter study
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2816, USA
    JAMA 285:761-8. 2001
    ..A previous study suggested that the combination of a normal D-dimer assay and normal alveolar dead-space fraction is a highly sensitive screening test for pulmonary embolism (PE)...
  13. ncbi Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center
    Annick Galetto-Lacour
    Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
    Pediatrics 112:1054-60. 2003
    ..To assess the value of bedside tests for predicting the occurrence of severe bacterial infections (SBIs) in children with fever without source...
  14. ncbi Bench to bedside: electrophysiologic and clinical principles of noninvasive hemodynamic monitoring using impedance cardiography
    Richard L Summers
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson 39216, USA
    Acad Emerg Med 10:669-80. 2003
  15. ncbi Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery
    Rajendra H Mehta
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 114:2208-16; quiz 2208. 2006
    ..Estimation of an individual patient's risk for postoperative dialysis can support informed clinical decision making and patient counseling...
  16. ncbi Safely ruling out deep venous thrombosis in primary care
    Harry R Buller
    Academic Medical Center, Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Ann Intern Med 150:229-35. 2009
    ..Up to 90% of patients referred for ultrasonography with suspected deep venous thrombosis (DVT) of the leg do not have the disease...
  17. ncbi Effectiveness of point-of-care testing for therapeutic control of chronic conditions: results from the PoCT in General Practice Trial
    Tanya K Bubner
    Discipline of General Practice, University of Adelaide, Adelaide, SA
    Med J Aust 190:624-6. 2009
    ..To compare the clinical effectiveness of point-of-care testing (PoCT) and that of pathology laboratory testing, as measured by therapeutic control in chronic conditions...
  18. ncbi Quantitative assessment of pleural effusion in critically ill patients by means of ultrasonography
    Philippe Vignon
    Medical Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    Crit Care Med 33:1757-63. 2005
    ..To assess the ability of ultrasonography to identify the presence and assess the volume of pleural effusion in the intensive care unit setting...
  19. ncbi Point of care testing in the emergency department
    Gregory J Fermann
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Emerg Med 22:393-404. 2002
    ..Patient care issues must be weighed against the cost of implementing POC testing and supporting the infrastructure needed to maintain this technology in the ED...
  20. pmc An evaluation of five bedside information products using a user-centered, task-oriented approach
    Rose Campbell
    Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Med Libr Assoc 94:435-41, e206-7. 2006
    ..The paper compares several bedside information tools using user-centered, task-oriented measures to assist those making or supporting purchasing decisions...
  21. ncbi Point-of-care versus central laboratory coagulation testing during haemorrhagic surgery. A multicenter study
    Pierre Toulon
    CHU, hopital de Cimiez, Service d Hematologie Biologique, 4 avenue de la Reine Victoria, BP 1179, F 06003 Nice Cedex 1, France
    Thromb Haemost 101:394-401. 2009
    ..These results suggest that, in providing a rapid answer, POC-based monitoring of PT (in percentage) using the CoaguChek device could be validly used in patients undergoing haemorrhagic surgical procedures...
  22. ncbi Answering questions at the point of care: do residents practice EBM or manage information sources?
    Gary McCord
    Department of Family Medicine, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Acad Med 82:298-303. 2007
  23. ncbi Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery
    L Shore-Lesserson
    Department of Anesthesiology, Mount Sinai Medical Center, New York, New York 10029, USA
    Anesth Analg 88:312-9. 1999
    ..These data support the use of TEG in an algorithm to guide transfusion therapy in complex cardiac surgery...
  24. ncbi Near-patient testing of potassium levels using arterial blood gas analysers: can we trust these results?
    R J P José
    Department of Intensive Care Medicine, Broomfield Hospital, Court Road, Broomfield CM1 7ET, UK
    Emerg Med J 25:510-3. 2008
    ..At times there is uncertainty whether clinical decisions can be based on the potassium result obtained from arterial blood gas (ABG) analysers or if laboratory values should be awaited...
  25. pmc Impact of surgeon-performed ultrasound on diagnosis of abdominal pain
    A Lindelius
    Karolinska Institutet, Department of Clinical Science and Education, Sodersjukhuset, Stockholm, Sweden
    Emerg Med J 25:486-91. 2008
    ..A randomised study was performed to evaluate the diagnostic accuracy of surgeon-performed ultrasound in the emergency department for patients presenting with abdominal pain...
  26. ncbi Focused ultrasound training for clinicians
    Suzanne Le P Langlois
    Department of Medical Imaging, The Townsville Hospital, Douglas, Queensland, Australia
    Crit Care Med 35:S138-43. 2007
    ..Training and supervision in rural, remote, and austere environments provides added challenges...
  27. ncbi Goal-directed abdominal ultrasonography: impact on real-time decision making in the emergency department
    David Bassler
    Department of Emergency Medicine, Alameda County Medical Center, Highland Hospital, Oakland, California 94602, USA
    J Emerg Med 24:375-8. 2003
    ..Bedside ultrasonography in the ED has an important impact on real-time decision-making, particularly in terms of the certainty of diagnosis...
  28. pmc Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial
    Jochen W L Cals
    Maastricht University, Care and Public Health Research Institute, Department of General Practice, Maastricht, The Netherlands
    BMC Fam Pract 8:15. 2007
    ..The aim of this paper is to describe the design and methods of a study to assess two interventions for improving LRTI management in general practice...
  29. ncbi Lung ultrasound in acute respiratory distress syndrome and acute lung injury
    Charlotte Arbelot
    Surgical Intensive Care Unit, Department of Anesthesiology and Critical Care, Assistance Publique Hopitaux de Paris, University of Paris 6 Pierre et Marie Curie, Paris, France
    Curr Opin Crit Care 14:70-4. 2008
    ..Lung ultrasound at the bedside can provide accurate information on lung status in critically ill patients with acute respiratory distress syndrome...
  30. ncbi Improved infrared spectrophotometer for point-of-care patient 13C-urea breath testing in the primary care setting
    Antone R Opekun
    Baylor College of Medicine, Department of Medicine, Family and Community Medicine, 6550 Fannin Street SM 1122, Houston, TX 77030 2399, USA
    Clin Biochem 38:731-4. 2005
    ..The 13C-urea breath test provides non-invasive testing for Helicobacter pylori infection with the possibility of analysis at the point of care. Point of care tests require accurate and efficient desktop instrumentation...
  31. ncbi Performance evaluation of a new compact hematology analyzer, the Sysmex pocH-100i
    C Briggs
    Department of Haematology, University College London Hospital, London, United Kingdom
    Lab Hematol 9:225-33. 2003
    ..Results for neutrophils (r2 = 0.996), lymphocytes (r2 = 0.999), and the "mixed" population of cells (r2 = 0.611) indicated the pocH-100i analyzer would be highly suitable for low-volume laboratories and near-patient services...
  32. ncbi Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients
    Jeffrey A Kline
    Director, Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    Chest 129:1417-23. 2006
  33. ncbi Is perioperative point-of-care prothrombin time testing accurate compared to the standard laboratory test?
    Natalie Urwyler
    University Department of Anesthesiology and Pain Therapy, University Hospital of Bern, Bern, Switzerland
    Thromb Haemost 102:779-86. 2009
    ..These findings suggest that PoC testing will be useful for monitoring intraoperative prothrombin time when coagulopathy is suspected. It could lead to a more rational use of expensive and limited blood bank resources...
  34. ncbi Quality assessment of CoaguChek point-of-care prothrombin time monitors: comparison of the European community-approved procedure and conventional external quality assessment
    Leon Poller
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Clin Chem 52:1843-7. 2006
  35. pmc Bedside diagnostic laparoscopy in the intensive care unit: a 13-year experience
    Eduardo J Jaramillo
    Texas Endosurgery Institute, San Antonio, Texas 78222, USA
    JSLS 10:155-9. 2006
    ..One option in the diagnosis of these difficult patients is bedside laparoscopy, as it avoids patient transport, is very accurate, and maintains ICU monitoring...
  36. ncbi Performance evaluation of the CoaguChek S system
    Winfried Plesch
    Haematologica 87:557-9. 2002
  37. ncbi Clinical experiences with a new semi-quantitative solid phase immunoassay for rapid measurement of procalcitonin
    M Meisner
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller Universitat Jena, Germany
    Clin Chem Lab Med 38:989-95. 2000
    ..However, for the follow-up of PCT concentrations and routine daily measurements, the quantitative luminometric assay should be preferred, when available...
  38. ncbi Usefulness of a hand-held ultrasound device for bedside examination of left ventricular function
    Bruce J Kimura
    Department of Cardiology, Scripps Mercy Medical Center, San Diego, California, USA
    Am J Cardiol 90:1038-9. 2002
  39. pmc Pilot study of a point-of-use decision support tool for cancer clinical trials eligibility
    P P Breitfeld
    Regenstrief Institute, Indiana University School of Medicine, Indianapolis 46202 2859, USA
    J Am Med Inform Assoc 6:466-77. 1999
    ..This decision support tool and the decision framework on which it is based could be used for multiple trials and different cancer sites...
  40. pmc Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients
    Anouk M Corstjens
    Department of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands
    Crit Care 10:R135. 2006
    ..The study was performed as a single-centre, prospective, observational study in a 12-bed medical ICU of a university hospital...
  41. ncbi Field evaluation of the performance and testing costs of a rapid point-of-care test for syphilis in a red-light district of Manaus, Brazil
    A S Benzaken
    Fundação Alfredo da Matta, Manaus, Brazil
    Sex Transm Infect 84:297-302. 2008
    ..To assess the performance, usefulness and cost of a rapid treponemal antibody assay (VisiTect Syphilis) to detect syphilis in high risk populations...
  42. pmc Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis
    D Mabey
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:v13-6. 2006
    ..To evaluate prospectively four rapid, point-of-care serological tests for syphilis in prenatal or high risk populations in four countries...
  43. ncbi The status of bedside ultrasonography training in emergency medicine residency programs
    Francis L Counselman
    Department of Emergency Medicine, Eastern Virginia Medical School, Norfolk 23507, USA
    Acad Emerg Med 10:37-42. 2003
    ..Program training content is currently driven by the recently published "Model of the Clinical Practice of Emergency Medicine," which includes BU as a necessary skill...
  44. pmc Do clinicians use online evidence to support patient care? A study of 55,000 clinicians
    Johanna I Westbrook
    Centre for Health Informatics, Level 2, Samuels Building, University of New South Wales, Kensington, 2052, Australia
    J Am Med Inform Assoc 11:113-20. 2004
  45. pmc Design and implementation of GRIP: a computerized glucose control system at a surgical intensive care unit
    Mathijs Vogelzang
    Department of Surgery, Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Med Inform Decis Mak 5:38. 2005
    ..Current nurse-driven protocols are paper-based and, therefore, rely on simple rules. For safety and efficiency a computer decision support system that employs complex logic may be superior to paper protocols...
  46. ncbi Pre-hospital detection of acute myocardial infarction with ultra-rapid human fatty acid-binding protein (H-FABP) immunoassay
    Patrick Ecollan
    SAMU, Pitie Salpetriere University Hospital, Paris, France
    Int J Cardiol 119:349-54. 2007
    ..To evaluate the diagnostic performance of a portable semi-quantitative whole blood immunoassay measuring soluble human fatty acid-binding protein [H-FABP] (CardioDetect) for the pre-hospital detection of myocardial infarction (MI)...
  47. ncbi Clinical evaluation of point-of-care-testing of heart-type fatty acid-binding protein (H-FABP) for the diagnosis of acute myocardial infarction
    Takao Tanaka
    Osaka Medical College, Takatsuki, Osaka, Japan
    J Immunoassay Immunochem 27:225-38. 2006
    ..3%, while it was 100% with cardiac troponin T. The POCT of H-FABP is thought to be practical for the detection of cardiac damage and effective for the diagnosis of AMI in superacute phase within 3 hours and/or 6 hours...
  48. pmc Randomised controlled trial of near-patient testing for glycated haemoglobin in people with type 2 diabetes mellitus
    Kamlesh Khunti
    Division of General Practice and Primary Health Care, Department of Health Sciences, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW
    Br J Gen Pract 56:511-7. 2006
    ..Tight glycaemic control in people with type 2 diabetes can lead to a reduction in microvascular and possibly macrovascular complications. The use of near-patient (rapid) testing offers a potential method to improve glycaemic control...
  49. ncbi Malaria rapid diagnostic tests in tropical climates: the need for a cool chain
    Pernille Jorgensen
    World Health Organization Regional Office for the Western Pacific, Manila, The Philippines
    Am J Trop Med Hyg 74:750-4. 2006
    ..These results emphasize the need for good logistical planning during the introduction of point-of-care tests in tropical countries and the importance of considering the stability of diagnostic tests during procurement...
  50. ncbi Validation of an insulin infusion nomogram for intensive glucose control in critically ill patients
    Clarence Chant
    Perioperative and Critical Care Services, Department of Pharmacy, St Michael s Hospital, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharmacotherapy 25:352-9. 2005
    ..To evaluate the effectiveness, safety, and associated patient outcomes of a simplified, nurse-directed insulin nomogram designed to achieve intensive blood glucose level control (target range 90-144 mg/dl)...
  51. ncbi Physician-performed point-of-care echocardiography using a laptop platform compared with physical examination in the cardiovascular patient
    K T Spencer
    Department of Cardiology, University of Chicago, Illinois 60637, USA
    J Am Coll Cardiol 37:2013-8. 2001
    ..The purpose of this study was to compare the results of physical examinations (PEs) performed by board-certified cardiologists with the results of point-of-care (POC) echocardiography in a group of patients with cardiovascular disease...
  52. ncbi Chest ultrasound for "Dummies"
    Peter Doelken
    Chest 123:332-3. 2003
  53. ncbi Comparison of the Simplify D-dimer assay performed at the bedside with a laboratory-based quantitative D-dimer assay for the diagnosis of pulmonary embolism in a low prevalence emergency department population
    M S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, North Carolina 28323 2861, USA
    Emerg Med J 25:70-5. 2008
    ..The immunofiltration D-dimer assay could allow point-of-care testing for pulmonary embolism (PE). A study was undertaken to compare a clinician-performed qualitative D-dimer assay with the automated quantitative D-dimer test...
  54. ncbi Use of a computer-based reminder to improve sedative-hypnotic prescribing in older hospitalized patients
    Joseph V Agostini
    Clinical Epidemiology Research Center, VA Connecticut Healthcare Center, West Haven, CT 06516, USA
    J Am Geriatr Soc 55:43-8. 2007
    ..To develop a feasible, inexpensive, point-of-care computerized reminder to improve sedative-hypnotic prescribing in hospitalized older people...
  55. pmc Testing for sexually transmitted infections: a brave new world?
    R W Peeling
    Sex Transm Infect 82:425-30. 2006
  56. ncbi Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery
    M S Avidan
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Br J Anaesth 92:178-86. 2004
  57. ncbi Rapid assessment of cardiac anatomy and function with a new hand-carried ultrasound device (OptiGo): a comparison with standard echocardiography
    M Rugolotto
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305-5233, USA
    Eur J Echocardiogr 2:262-9. 2001
  58. ncbi [Bedside thrombelastography. Cost reduction in cardiac surgery]
    G J Spalding
    Herzchirurgie, Herzzentrum Brandenburg, Ladeburger Strasse 17, 16321 Bernau bei Berlin
    Anaesthesist 56:765-71. 2007
    ..We analyzed the bedside coagulation test (ROTEM) in order to verify clot forming quality and to find a cost-effective treatment algorithm...
  59. ncbi Oxygen effects on glucose meter measurements with glucose dehydrogenase- and oxidase-based test strips for point-of-care testing
    Z Tang
    Point-of-Care Testing Center for Teaching and Research, University of California, Davis, CA, USA
    Crit Care Med 29:1062-70. 2001
  60. pmc Using wireless handheld computers to seek information at the point of care: an evaluation by clinicians
    Susan E Hauser
    Lister Hill National Center for Biomedical Communications, National Library of Information, 8600 Rockville Pike, Bethesda, MD 20894, USA
    J Am Med Inform Assoc 14:807-15. 2007
    ..To evaluate: (1) the effectiveness of wireless handheld computers for online information retrieval in clinical settings; (2) the role of MEDLINE in answering clinical questions raised at the point of care...
  61. pmc Clinical team functioning and IT innovation: a study of the diffusion of a point-of-care online evidence system
    A Sophie Gosling
    Centre for Health Informatics, Faculty of Medicine, University of New South Wales, Sydney, Australia
    J Am Med Inform Assoc 10:244-51. 2003
    ..To examine the relationships between clinical team characteristics and the adoption of the online evidence system...
  62. pmc Innovations in technology for critical care medicine
    Martin Chapman
    University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Crit Care 8:74-6. 2004
    ..The monitoring section discusses recent claims of improved efficiency with telemedicine for intensive care units...
  63. ncbi Accurate and precise isotope dilution mass spectrometry method for determining glucose in whole blood
    U Hannestad
    Department of Clinical Chemistry, University Hospital, Linkoping, Sweden
    Clin Chem 43:794-800. 1997
    ..For all samples the HemoCue analyzer results had a mean bias of +2.0% compared with the ID GC-MS results...
  64. ncbi Bedside functional imaging of the premature infant brain during passive motor activation
    S R Hintz
    Biomedical Optics Group, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Hansen Physics Laboratory, Palo Alto, California, USA
    J Perinat Med 29:335-43. 2001
    ..Imaging methods, which use near-infrared light allow for non-invasive measurements by taking advantage of the fact that hemoglobin is a strong absorber at these wavelengths...
  65. ncbi Pilot study of the accuracy of bedside glucometry in the intensive care unit
    J G Ray
    Division of Critical Care, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 29:2205-7. 2001
  66. ncbi Utility and diagnostic accuracy of hand-carried ultrasound for emergency room evaluation of chest pain
    Shaul Atar
    Department of Cardiology, Ha Emek Medical Center, Afula, Israel
    Am J Cardiol 94:408-9. 2004
  67. ncbi How useful is hand-carried bedside echocardiography in critically ill patients?
    G M Goodkin
    Noninvasive Cardiology Laboratory, New York University School of Medicine, New York 10016, USA
    J Am Coll Cardiol 37:2019-22. 2001
    ..The study compared a hand-carried echocardiography (HC) device with standard echocardiography (SE) in critically ill patients...
  68. ncbi Neurointensive care unit system for continuous electrophysiological monitoring with remote web-based review
    Andre J W van der Kouwe
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    IEEE Trans Inf Technol Biomed 7:130-40. 2003
    ..We demonstrate its application in a few diverse neurological intensive care cases and a case in the interventional neuroradiology suite...
  69. ncbi Reliability of point-of-care hematocrit, blood gas, electrolyte, lactate and glucose measurement during cardiopulmonary bypass
    J Steinfelder-Visscher
    Department of Extra Corporeal Circulation, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Perfusion 21:33-7. 2006
    ..In this prospective clinical study, the analytical performance of the GEM Premier 3000 was compared with the Ciba Corning 865 analyser for blood gas/electrolytes/metabolites, and for hematocrit with the Sysmex XE 2100 instrument...
  70. ncbi Seroprotection against tetanus in patients attending an emergency department in Belgium and evaluation of a bedside immunotest
    Muriel Stubbe
    Department of Emergency Medicine, Erasme University Hospital, Brussels, Belgium
    Eur J Emerg Med 14:14-24. 2007
    ..In most emergency departments, tetanus prophylaxis currently relies on vaccination history. Bedside evaluation of tetanus immunity may improve this process...
  71. ncbi The Massey Bedside Swallowing Screen
    Regina Massey
    Mount Carmel College of Nursing, Epilepsy Center Mount Carmel West Neurology Center of Columbus, USA
    J Neurosci Nurs 34:252-3, 257-60. 2002
    ..Sensitivity and specificity were calculated as 100%. The chi-square test showed that use of the Massey Bedside Swallowing Screen might provide nurses with a useful tool for assessing swallowing function of patients with a stroke...
  72. ncbi Are the Duke criteria really useful for the early bedside diagnosis of infective endocarditis? Results of a prospective multicenter trial
    Enrico Cecchi
    Cardiology Department, Maria Vittoria Hospital, Turin, Italy
    Ital Heart J 6:41-8. 2005
  73. ncbi Accuracy of the CoaguChek XS for point-of-care international normalized ratio (INR) measurement in children requiring warfarin
    Mary E Bauman
    Stollery Children s Hospital, University of Alberta, Edmonton, AB, Canada
    Thromb Haemost 99:1097-103. 2008
    ..11 (-0.20; 0.42) and 0.13 (-0.22; 0.48) at the two time points, respectively. In conclusion, the CoaguChek XS meter appraisal generates an accurate and precise INR measure in children when compared to laboratory INR test results...
  74. ncbi The quick-read C-reactive protein test for the prediction of bacterial gastroenteritis in the pediatric emergency department
    Nufar Marcus
    Unit of Emergency Medicine, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Pediatr Emerg Care 23:634-7. 2007
    ..To determine the clinical usefulness of the bedside Quick-Read (QR) C-reactive protein (CRP) test for predicting bacterial gastroenteritis in the pediatric emergency department...
  75. ncbi Triage patients with suspected pulmonary embolism in the emergency department using a portable ultrasound device
    Nicolas Mansencal
    Department of Cardiology, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, UFR de médecine Paris Île de France Ouest, Faculté de Versailles Saint Quentin en Yvelines, Boulogne, France
    Echocardiography 25:451-6. 2008
  76. ncbi Accuracy of bedside glucometry in critically ill patients: influence of clinical characteristics and perfusion index
    Arnaud Desachy
    Medical Surgical Intensive Care Unit, Centre Hospitalier General, Angouleme, France
    Mayo Clin Proc 83:400-5. 2008
    ..To determine the accuracy of bedside glucose strip assay on capillary blood and on whole blood and to identify factors predictive of discrepancies with the laboratory method...
  77. ncbi Anticoagulation monitoring part 1: warfarin and parenteral direct thrombin inhibitors
    Sarah A Spinler
    Cardiovascular Division, Department of Medicine, Philadelphia College of Pharmacy, University of Pennsylvania, Philadelphia, PA 19104 4495, USA
    Ann Pharmacother 39:1049-55. 2005
    ..To review the availability, mechanisms, limitations, and clinical application of point-of-care (POC) devices used in the management of warfarin and parenteral direct thrombin inhibitors...
  78. ncbi Comparison of ACT point-of-care measurements: repeatability and agreement
    Y P J Bosch
    Department of Extra Corporeal Circulation, University Hospital Maastricht, Maastricht, The Netherlands
    Perfusion 21:27-31. 2006
  79. ncbi A novel method for insertion of post-pyloric feeding tubes at the bedside without endoscopic or fluoroscopic assistance: a prospective study
    Cornelis Slagt
    Department of Anaesthesiology, General Hospital De Heel, Zaans Medical Center, P O Box 210, 1500 EE Zaandam, The Netherlands
    Intensive Care Med 30:103-7. 2004
    ..To assess a novel method, adapted from already published literature, for bedside placement of nasojejunal feeding tubes using erythromycin, air insufflation of the stomach and continuous ECG guidance...
  80. ncbi Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study
    Fernando Suarez-Sipmann
    Intensive Care Unit, Fundacion Jimenez Diaz Capio, Avenida de los Reyes Catolicos 2, 28010 Madrid, Spain
    Crit Care Med 35:214-21. 2007
    ..We tested whether the continuous monitoring of dynamic compliance could become a useful bedside tool for detecting the beginning of collapse of a fully recruited lung...
  81. ncbi European Concerted Action on Anticoagulation (ECAA): multicentre international sensitivity index calibration of two types of point-of-care prothrombin time monitor systems
    L Poller
    ECAA Central Facility, School of Biological Sciences, The University of Manchester, Manchester, UK
    Br J Haematol 116:844-50. 2002
    ..In these circumstances, the modified WHO-type ISI calibration appeared to be satisfactory for the POCT whole-blood monitors...
  82. ncbi How accurate are currently used methods of determining glycemia in critically ill patients, and do they affect their clinical course?
    G Chrousos
    Crit Care Med 33:2849-51. 2005
  83. ncbi Point-of-care test identifies diabetic ketoacidosis at triage
    Rosanne Naunheim
    Department of Emergency Medicine, Washington University, St Louis, MO, USA
    Acad Emerg Med 13:683-5. 2006
  84. ncbi Precision and accuracy of the bedside examination in detecting an ejection fraction of less than 40% following acute myocardial infarction
    D Massel
    Department of Medicine, University of Western Ontario, London, Ontario
    Can J Cardiol 20:411-6. 2004
    ..Left ventricular function is the most important determinant of prognosis following myocardial infarction...
  85. ncbi Bedside tests of B-type natriuretic peptide in the diagnosis of left ventricular diastolic dysfunction in hypertensive patients
    Tiemin Wei
    Department of Cardiology, Lishui City Central Hospital, Zhejiang Province, PR China
    Eur J Heart Fail 7:75-9. 2005
    ..To investigate the value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction in patients with hypertension...
  86. ncbi Measuring statistical agreement between four point of care (POC) lactate meters and a laboratory blood analyzer in cats
    Mark J Acierno
    Department of Veterinary Clinical Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70810, USA
    J Feline Med Surg 10:110-4. 2008
    ..Other commercially available POC meters produced acceptable agreement...
  87. ncbi Handheld, portable ultrasound in the neonatal intensive care nursery: a new, inexpensive tool for the rapid diagnosis of common neonatal problems
    Vladimir Burdjalov
    Department of Pediatrics, Division of Neonatology, SUNY Stony Brook, Stony Brook, NY 11794 8111, USA
    J Perinatol 22:478-83. 2002
    ..This paper illustrates some of the capabilities of this simplified device, and the value of having continuous on-site ultrasound availability in the NICU...
  88. ncbi [Pruritometer 1: Portable measuring system for quantifying scratching as an objective measure of cholestatic pruritus]
    H Stein
    Biomed Tech (Berl) 41:248-52. 1996
    ..Pruritometer 2, which will enable scratch frequency and intensity distribution over time to be determined, is presently being developed...
  89. ncbi Minimum numbers of fresh whole blood and plasma samples from patients and healthy subjects for ISI calibration of CoaguChek and RapidPointCoag monitors
    Leon Poller
    European Concerted Action on Anticoagulation, Central Facility, School of Biological Sciences, University of Manchester, England
    Am J Clin Pathol 117:892-9. 2002
  90. ncbi Goal-directed ultrasound in the detection of long-bone fractures
    Thomas H Marshburn
    Medical Operations, Office of Space Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    J Trauma 57:329-32. 2004
    ..New portable ultrasound (US) systems are capable of detecting fractures in the remote setting. However, the accuracy of ultrasound by physicians with minimal ultrasound training is unknown...
  91. ncbi Point of care blood ketone testing of diabetic patients in the emergency department
    Firat Bektas
    Department of Emergency Medicine, School of Medicine, University of Akdeniz, Antalya, Turkey
    Endocr Res 30:395-402. 2004
    ..This device can be used as a reliable diagnostic test to detect emergency metabolic problems in diabetic patients, such as diabetic ketosis or ketoacidosis...
  92. ncbi Real-time B-mode ultrasound in the ED saves time in the diagnosis of deep vein thrombosis (DVT)
    Daniel Theodoro
    Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York, USA
    Am J Emerg Med 22:197-200. 2004
    ..0001). EPs and ISs had excellent agreement (kappa = 0.9). Compression ultrasound performed by EPs resulted in a significant decreased time to disposition. Agreement with ISs was excellent...
  93. ncbi Accuracy of capillary whole blood international normalized ratio on the CoaguChek S, CoaguChek XS, and i-STAT 1 point-of-care analyzers
    Brad S Karon
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Clin Pathol 130:88-92. 2008
    ..5 INR units from the reference method. Median bias between CoaguChek S capillary whole blood and laboratory plasma INRs changed over time, demonstrating the need for ongoing quality assurance measures for POC INR programs...
  94. ncbi ABSCESS: applied bedside sonography for convenient evaluation of superficial soft tissue infections
    Benjamin T Squire
    Department of Emergency Medicine, University of California, Irvine, Orange, CA 92868, USA
    Acad Emerg Med 12:601-6. 2005
    ..Soft tissue infections are a common presenting complaint in the emergency department (ED). The authors sought to determine the utility of ED bedside ultrasonography (US) in detecting subcutaneous abscesses...
  95. ncbi Bedside diagnosis of coronary artery disease: a systematic review
    Andrea Akita Chun
    Department of General Internal Medicine, University of Washington, Harborview Medical Center, Seattle 98104 2499, USA
    Am J Med 117:334-43. 2004
    ..To assess the accuracy of bedside findings for diagnosing coronary artery disease and acute myocardial infarction...
  96. ncbi Community screening for left ventricular hypertrophy in patients with hypertension using hand-held echocardiography
    Roxy Senior
    Department of Cardiovascular Medicine, Northwick Park Hospital, Watford Rd, Harrow, Middlesex, HAI 3UJ United Kingdom
    J Am Soc Echocardiogr 17:56-61. 2004
    ..Thus, hand-held echocardiography devices accurately assessed LVH and may be used for community-based screening for LVH in targeted patients with hypertension...
  97. ncbi Point-of-care urinary pneumococcal antigen test in the emergency department for community acquired pneumonia
    C Weatherall
    Department of Microbiology and Infectious Diseases, Concord Repatriation General Hospital, Sydney, Australia
    Emerg Med J 25:144-8. 2008
    ..A study was undertaken to assess whether PNAG testing can be reliably performed and interpreted by staff in an adult emergency department and whether rapid results influence initial treatment decisions...
  98. ncbi Evaluation of Binax NOW RSV as an acute point-of-care screening test in a paediatric accident and emergency unit
    P L Mackie
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN
    Commun Dis Public Health 7:328-30. 2004
    ..The simplicity of Binax NOW RSV should not detract from training staff and maintaining consistent vigilance on quality control...
  99. ncbi Focused assessment with sonography for trauma patients by clinicians: Initial experience and results
    John Vassiliadis
    Department of Emergency Medicine, Division of Surgery, Westmead Hospital, Westmead, New South Wales, Australia
    Emerg Med (Fremantle) 15:42-8. 2003
    ..To describe the establishment of a service to provide bedside focused assessment sonography in trauma and to evaluate the service to date...
  100. ncbi B-type natriuretic peptide rapid assay: a diagnostic test for heart failure
    Irma B Ancheta
    University of Phoenix, Jacksonville, FL 32218, USA
    Dimens Crit Care Nurs 25:149-54; quiz 155-6. 2006
    ..This article focuses on the description of the diagnostic performance of the BNP rapid assay, its clinical dimensions, and its implications to nursing practice and collaborative practice models...
  101. ncbi Diagnostic accuracy of the Triage D-dimer test for exclusion of venous thromboembolism in outpatients
    Timothy Ghys
    Department of Hematology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Thromb Res 121:735-41. 2008
    ..We evaluated the diagnostic performance of the Triage D-dimer test, a new fast quantitative point-of-care whole blood D-dimer assay and compared it with the Vidas D-dimer assay...

Research Grants70

  1. Technology to Improve Medication Safety in Nursing Homes
    Jill Scott Cawiezell; Fiscal Year: 2004
    ARIEH KARGER; Fiscal Year: 2001
  3. Electric-Field Assisted Isothermal On-Chip Amplification of DNA
    Dalibor Hodko; Fiscal Year: 2006
    ..Potential applications are envisioned in portable and/or point of care systems for detection of pathogens, infectious diseases and/or biological agents and emerging pathogens...
  4. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..abstract_text> ..
  5. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2008
    ..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
  6. Physician Training Program in Neonatal Biology
    John Widness; Fiscal Year: 2007
    ..With NIH support beyond that which the investigators currently enjoy, the investigators will be able to significantly enhance the research training experiences they offer their postdoctoral physician trainees in neonatal medicine. ..
  7. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
  8. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  9. Parent Initiated Prevention Program
    Dimitri Christakis; Fiscal Year: 2005
    ..3) To improve parental perceptions of the quality of care provided.H3: Compared to controls, PIPP parents will report higher scores on selected Consumer Assessment of Health Plans (CAHPS) items. ..
  10. p12CDK2-AP1 in Cell Cycle Control & Oral Carcinogenesis
    David Wong; Fiscal Year: 2006
    ..abstract_text> ..
  11. Insular AD Pathology and Autonomic Function
    Donald Royall; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. Usability Testing of a CDSS for Tobacco Use Treatment
    THEODORE MARCY; Fiscal Year: 2005
    ..The effectiveness of the developed through this process would be assessed in a subsequent research proposal using a randomized controlled trial design. ..
  13. Oral-Based Diagnostics
    Daniel Malamud; Fiscal Year: 2006
    ..This conference will focus on advances and new technologies in the oral diagnostics field and their utility for detection of health status. [unreadable] [unreadable] [unreadable]..
  14. Creighton Health Services Research Development Project
    Kimberly Galt; Fiscal Year: 2007
    ..Funding of this BRIC will facilitate the capacity needed to advance the Creighton University's health services research mission in a more rapid and sustainable fashion. [unreadable] [unreadable] [unreadable] [unreadable]..
  15. CPP Management Information Feedback and Nursing
    Catherine Kirkness; Fiscal Year: 2007
    ..abstract_text> ..
  16. NIH Task Force on Childhood Motor Disorders
    Terence Sanger; Fiscal Year: 2006
    ..The ultimate objective is to improve the functional abilities and societal participation of children with motor disorders. ..
  17. Palliative Oxygen for the Relief of Breathlessness
    Amy Abernethy; Fiscal Year: 2007
    ..The results will also advance a long-standing international debate about the role of palliative oxygen for intractable dyspnea and it's funding. [unreadable] [unreadable] [unreadable]..
  18. Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's Syndrome
    David T Wong; Fiscal Year: 2010
  19. Towards Mega-Throughput, Label-free Genomics and Proteomics: Revolutionizing Micr
    Aydogan Ozcan; Fiscal Year: 2009
  20. Computer Decision Aid for ADHD Management (CDAAM)
    Aaron E Carroll; Fiscal Year: 2010
    ..We will assess the quality of ADHD services at baseline and again at 12 months post implementation. These methods will allow a thorough description of the intervention's role in the process of ADHD management. ..
  21. Improving Heart Failure Risk Stratification in the ED
    Alan B Storrow; Fiscal Year: 2010
    ..In collaboration with outcomes and effectiveness researchers, we plan to conduct further studies to test the efficacy of our risk model. ..
    Joseph Wang; Fiscal Year: 2008
    ..The perturbance of such fluxes by surface binding events will be used to explore novel approaches to biosensing at liquid-polymer interfaces. ..
  23. Medication Reconciliation: A Team Approach
    Jeffrey Greenwald; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Mobile Tool for Adolescent Diabetes Management
    Aaron Carroll; Fiscal Year: 2008
    ..This research request will form the foundation of an R01 proposal to rigorously study the tool's impact on adolescent diabetes management ..
  25. Gastric Tube Placement in Young Children
    Marsha Ellett; Fiscal Year: 2008
    ..Results from this study will increase the safety of using gastric tubes in young children. ..
  26. Reducing Harm to Patients from Diagnostic Errors
    ETA BERNER; Fiscal Year: 2007
    ..To leverage AHRQ funding, additional support will be provided by registration fees, vendors, non-profit organizations and in-kind logistic support from the Society for Medical Decision Making. [unreadable] [unreadable] [unreadable]..
  27. Creation and demonstration of a palliative care research cooperative group
    Jean S Kutner; Fiscal Year: 2010
  28. VAS-COG 2007
    Donald Royall; Fiscal Year: 2007
    ..Many vascular cognitive disorders are preventable and potentially reversible. VAS-COG will provide a forum in which information on these important conditions can be exchanged and disseminated. [unreadable] [unreadable] [unreadable]..
  29. Physician Adherence to Tobacco Use Treatment Guidelines
    THEODORE MARCY; Fiscal Year: 2005
    ..The candidate's work will be under the sponsorship of Dr. Brian Flynn of the Office of Health Promotion Research at the University of Vermont. ..
  30. Anti-HIV Activity of Lung SRCR (gp-340) in Saliva
    Daniel Malamud; Fiscal Year: 2005
    ..abstract_text> ..
    Christine Haller; Fiscal Year: 2004
    ..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
  32. A Microfluidic Diffusion Immunoassay
    Paul Yager; Fiscal Year: 2004
    ..abstract_text> ..
    Wilson Smart; Fiscal Year: 2004
    ..abstract_text> ..
  34. Childhood Motor Impairment and Assisted Communication
    Terence Sanger; Fiscal Year: 2004
  35. Research Infrastructure Improvement for The UCLA SOD
    David Wong; Fiscal Year: 2003
    ..abstract_text> ..
  36. Online MRI Positioning and Real-Time Motion Correction
    Andre van der Kouwe; Fiscal Year: 2004
    ..The technology will be evaluated in a group of healthy volunteers. ..
  37. UCLA Collaborative Oral Fluid Diagnostic Research Center
    David Wong; Fiscal Year: 2005
    ..The translational applications and opportunities are enormous. Significant institutional commitments and corporate sponsorships are in place, fulfilling the research, training, as well as technology transfer missions of NIDCR. ..
    L Newby; Fiscal Year: 2003
  39. A Microfluidic Diffusion Immunoassay
    Paul Yager; Fiscal Year: 2002
    ..abstract_text> ..
    Gregory Jay; Fiscal Year: 2003
    ..This principal goal of this investigation is to develop new immunological probes and with these identify the concentration of lubricin in synovial fluid extracted from healthy and arthritic human joints. ..
  41. Arm Kinematics in Hyperkinetic Cerebral Palsy
    Terence Sanger; Fiscal Year: 2005
    ..Hlatky will guide the design and implementation of clinical trials and outcome measure validation. The proposal includes coursework in cellular and molecular neurobiology and in the design of clinical research studies. ..
  42. Point Detection of Pathogens in Oral Samples via UPT
    Daniel Malamud; Fiscal Year: 2005
    ..We now present a plan to combine these separate analyses into a single system that can be used on-site to analyze up to 200 target analytes. ..
    Daniel Malamud; Fiscal Year: 2001
    ..3. To determine the mechanism by which salivary proteins inhibit HIV infectivity using in vitro models of oral infection. 4. To define the significance of anti-HIV proteins in saliva obtained from HIV-seropositive donors. ..
  44. Aptamer Chips for Clinical Monitoring of Target Proteins
    Wilson Smart; Fiscal Year: 2002
  45. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  46. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Genomics and Proteomics of Oral Precancer Progression
    David Wong; Fiscal Year: 2009
    ..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
  48. Internet Based Patient-Centered Asthma Management System
    Dimitri Christakis; Fiscal Year: 2009
    ..Children in AsthmaNet families will be more likely to report using written care plans. Aim 4: to decrease the number of symptom days for children with asthma H4. Children in AsthmaNet families will experience fewer symptom days. ..
  49. Dyspraxia and Autonomic Control in Very Early AD
    Donald Royall; Fiscal Year: 2004
    ..Some dementia treatments are known to reduce HRV, and possibly mortality as well. Alternatively, some psychotropics may increase arrhythmia-related mortality, possibly via a central mechanism. ..
  50. Expression Profiling in Canine Models of Human Disease
    Gordon Tomaselli; Fiscal Year: 2005
    ..As expression profile data is generated, it will be incorporated into a web-based database of canine gene expression profiles. ..
  51. Chronic Kidney Disease Morbidity, Mortality & Predictors
    Stephen Derose; Fiscal Year: 2005
    ..Researchers may use this information to generate hypotheses and plan studies that include subjects with CKD. ..
  52. Breast Cancer Multi-dimensional Diffuse Optical Imaging
    Bruce Tromberg; Fiscal Year: 2007
    ..g. hormone replacement therapy (HRT) and neoadjuvant chemotherapy). ..
  53. Nanoliter Lab-on-a-chip for Protein Crystallization
    Vamsee Pamula; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. Rapid parallel salivary immunoassays on a disposable
    Paul Yager; Fiscal Year: 2005
    ..Finally, a versatile combined system will be designed and tested that will allow monitoring of samples by the two methods simultaneously. ..
  55. Neural control of abnormal movement
    Terence Sanger; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  56. Creating Digital Partnerships for Health
    Alwyn Cohall; Fiscal Year: 2008
    ..Additionally, Digital Partners will assist the HHPC and its community advisory board in developing, implementing, evaluating and disseminating research findings. ..
    Helaine Resnick; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  58. Rapid Detection of Mycobacterium tuberculosis
    Susan Dorman; Fiscal Year: 2007
    ..unreadable] [unreadable] Relevance: Results of these studies will improve our understanding of the laboratory performance and clinical benefit of this test, and lead to improved detection and treatment of TB. [unreadable] [unreadable]..
  59. Reducing the Disproportionate Burden of Orofacial Injury
    Vivek Shetty; Fiscal Year: 2007
    ..abstract_text> ..
  60. Mycobacterium tuberculosis cell wall virulence factors
    Susan Dorman; Fiscal Year: 2004
    ..Finally, new information from the proposed self-contained pilot studies will serve as the foundation for future comprehensive dissection of macrophage response pathways affected by specific cell wall components. ..
  61. Lab-on-a-chip for multiplexed newborn screening of lysosomal storage disorders
    Vamsee Pamula; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. Towards drugs that prevent resistance to the HIV OI, TB
    David Alland; Fiscal Year: 2006
    ..if embB306 mutations affect biosynthesis of LAM, capped LAM, arabinogalactan (AG) or other cell wall components in the presence and absence of EMB. ..
  63. Building a New Model for Diagnosis of ED Dizzy Patients
    David Newman Toker; Fiscal Year: 2007
    ..This research project and the research paradigms derived from it will form the nucleus of a career devoted to research in medical decision-making, causes of diagnostic errors, and methods to preventthem. ..
    David Alland; Fiscal Year: 2005
    ..4) To identify and validate an informative set of SNPs for worldwide evolutionary and epidemiological analyses. ..
  65. Nanoliter Lab-on-a-Chip for Rapid Parallel Immunoassays
    Vamsee Pamula; Fiscal Year: 2006
    ..Our eventual goal is to develop a nanoliter, rapid, fully automated, hand-held point-of-analysis/point-of-care analyzer that integrates clinical chemistry, molecular diagnostics, and immunoassays. [unreadable] [unreadable] [unreadable]..
    David Alland; Fiscal Year: 2004
    ..Studies of these sequence variations in clinical strains will be used to determine the associations between specific mutations and the phenotypes of infectivity and virulence. ..
  67. Detection of Select Agents in Single-Well Assays
    David Alland; Fiscal Year: 2007
    ..3. To develop PCR assays that utilize "color-triplet coding" to uniquely label as many as 56 different species-specific molecular beacons. ..
  68. Sample Processing Cartridges for Rapid PCR TB Detection
    David Alland; Fiscal Year: 2008
    ..The system will then be retested using a large number of clinical sputum specimens. Finally, we will develop complete documentation on the assay including production, and development reports. [unreadable] [unreadable] [unreadable]..