critical pathways


Summary: Schedules of medical and nursing procedures, including diagnostic tests, medications, and consultations designed to effect an efficient, coordinated program of treatment. (From Mosby's Medical, Nursing & Allied Health Dictionary, 4th ed)

Top Publications

  1. ncbi In-hospital care pathways for stroke: a Cochrane systematic review
    Joseph Kwan
    Department of Medicine for the Elderly, Princess Margaret Hospital, Wiltshire, UK
    Stroke 34:587-8. 2003
  2. ncbi Case management "within the walls": a glimpse into the future
    Linda Yamamoto
    Scripps Mercy Hospital, San Diego, CA 92103, USA
    Crit Care Nurs Q 28:162-78. 2005
  3. pmc Effects of clinical pathways in the joint replacement: a meta-analysis
    A Barbieri
    Department of Clinical and Experimental Medicine, University of Eastern Piedmont A, Avogadro, Novara, Italy
    BMC Med 7:32. 2009
  4. ncbi Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs
    Thomas Rotter
    Department of Public Health, Dresden Medical School, University of Dresden, Dresden, Germany, D 01307
    Cochrane Database Syst Rev 3:CD006632. 2010
  5. pmc Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer
    Wenjuan Mo
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    PLoS ONE 8:e56592. 2013
  6. ncbi Do multidisciplinary integrated care pathways improve interprofessional collaboration?
    Anita Atwal
    Brunel University, Uxbridge, Middlesex, UK
    Scand J Caring Sci 16:360-7. 2002
  7. ncbi The enhanced recovery after surgery (ERAS) pathway for patients undergoing colorectal surgery: an update of meta-analysis of randomized controlled trials
    Liang Lv
    Department of General Surgery, Affiliated Hospital, Qingdao University Medical College, Jiangsu Road 16, Qingdao, 266003, China
    Int J Colorectal Dis 27:1549-54. 2012
  8. ncbi Impact of a pediatric asthma clinical pathway on hospital cost and length of stay
    A Wazeka
    Department of Pediatrics, New York Presbyterian Hospital and Joan and Sanford Weill Medical College, Cornell University, New York, New York 10021, USA
    Pediatr Pulmonol 32:211-6. 2001
  9. ncbi Shortened length of stay and hospital cost reduction with implementation of an accelerated clinical care pathway after elective colon resection
    Antonia E Stephen
    Department of Surgery, Massachusetts General Hospital, Boston 02114, USA
    Surgery 133:277-82. 2003
  10. ncbi What determines length of stay after total hip and knee arthroplasty? A nationwide study in Denmark
    Henrik Husted
    Department of Orthopaedics, Hvidovre Hospital, 2650, Hvidovre, Denmark
    Arch Orthop Trauma Surg 130:263-8. 2010

Detail Information

Publications270 found, 100 shown here

  1. ncbi In-hospital care pathways for stroke: a Cochrane systematic review
    Joseph Kwan
    Department of Medicine for the Elderly, Princess Margaret Hospital, Wiltshire, UK
    Stroke 34:587-8. 2003
  2. ncbi Case management "within the walls": a glimpse into the future
    Linda Yamamoto
    Scripps Mercy Hospital, San Diego, CA 92103, USA
    Crit Care Nurs Q 28:162-78. 2005
    ..This article presents the nurse case manager's involvement with a patient in the critical care unit who sustained an aneurysmal subarachnoid hemorrhage. A glimpse into the future will be viewed...
  3. pmc Effects of clinical pathways in the joint replacement: a meta-analysis
    A Barbieri
    Department of Clinical and Experimental Medicine, University of Eastern Piedmont A, Avogadro, Novara, Italy
    BMC Med 7:32. 2009
  4. ncbi Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs
    Thomas Rotter
    Department of Public Health, Dresden Medical School, University of Dresden, Dresden, Germany, D 01307
    Cochrane Database Syst Rev 3:CD006632. 2010
    ..AUTHORS' CONCLUSIONS: Clinical pathways are associated with reduced in-hospital complications and improved documentation without negatively impacting on length of stay and hospital costs...
  5. pmc Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer
    Wenjuan Mo
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    PLoS ONE 8:e56592. 2013
    ..Our study gives certain clues on miRNAs mediated AR signalling to cell viability by influencing critical pathways, especially by breaking through androgen's growth restriction effect on normal prostate tissue.
  6. ncbi Do multidisciplinary integrated care pathways improve interprofessional collaboration?
    Anita Atwal
    Brunel University, Uxbridge, Middlesex, UK
    Scand J Caring Sci 16:360-7. 2002
    ..Furthermore, key factors in discharge delays appeared to be organizational rather than professional...
  7. ncbi The enhanced recovery after surgery (ERAS) pathway for patients undergoing colorectal surgery: an update of meta-analysis of randomized controlled trials
    Liang Lv
    Department of General Surgery, Affiliated Hospital, Qingdao University Medical College, Jiangsu Road 16, Qingdao, 266003, China
    Int J Colorectal Dis 27:1549-54. 2012
    ..This study aimed to produce a comprehensive, up-to-date meta-analysis exploring the safety and efficacy of enhanced recovery programs after colorectal resection...
  8. ncbi Impact of a pediatric asthma clinical pathway on hospital cost and length of stay
    A Wazeka
    Department of Pediatrics, New York Presbyterian Hospital and Joan and Sanford Weill Medical College, Cornell University, New York, New York 10021, USA
    Pediatr Pulmonol 32:211-6. 2001
    ..02%. The implementation of a pediatric asthma clinical pathway, directed by specialists, resulted in significantly decreased length of stay and overall cost, without an increased rate of readmission...
  9. ncbi Shortened length of stay and hospital cost reduction with implementation of an accelerated clinical care pathway after elective colon resection
    Antonia E Stephen
    Department of Surgery, Massachusetts General Hospital, Boston 02114, USA
    Surgery 133:277-82. 2003
    ..The average hospital stay after colonic resection is 5 to 10 days. This study describes a clinical pathway for colon resections and examines patient outcome before and after institution of the pathway...
  10. ncbi What determines length of stay after total hip and knee arthroplasty? A nationwide study in Denmark
    Henrik Husted
    Department of Orthopaedics, Hvidovre Hospital, 2650, Hvidovre, Denmark
    Arch Orthop Trauma Surg 130:263-8. 2010
  11. pmc A systematic review and meta-analysis of the effects of clinical pathways on length of stay, hospital costs and patient outcomes
    Thomas Rotter
    Department of Public Health, Dresden Medical School, University of Dresden, Dresden, Germany
    BMC Health Serv Res 8:265. 2008
    ..To provide a framework for local healthcare organisations considering the effectiveness of clinical pathways as a patient management strategy...
  12. ncbi A neurological care pathway for meeting the palliative care needs of people with life-limiting neurological conditions
    Janice Barbara Brown
    School of Health Sciences, University of Southampton, Highfield
    Int J Palliat Nurs 15:120-7. 2009
  13. pmc An emergency clinical pathway for stroke patients--results of a cluster randomised trial (isrctn41456865)
    Assunta De Luca
    Public Health Agency of the Latium Region, Rome, Italy
    BMC Health Serv Res 9:14. 2009
    ..Emergency Clinical Pathways (ECP) for stroke have never been tested in randomized controlled trials (RCTs)...
  14. ncbi Effect of a clinical pathway to reduce hospitalizations in nursing home residents with pneumonia: a randomized controlled trial
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 295:2503-10. 2006
    ..Nursing home residents with pneumonia are frequently hospitalized. Such transfers may be associated with multiple hazards of hospitalization as well as economic costs...
  15. ncbi Care pathways lead to better teamwork: results of a systematic review
    Svin Deneckere
    Public Health School, Faculty of Medicine, KU Leuven, Belgium
    Soc Sci Med 75:264-8. 2012
    ..To achieve this, each care pathway requires a clearly defined team approach customized to the individual teams' needs...
  16. ncbi Early administration of systemic corticosteroids reduces hospital admission rates for children with moderate and severe asthma exacerbation
    Sanjit K Bhogal
    Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Ann Emerg Med 60:84-91.e3. 2012
    ..We examine the effect of early (within 60 minutes [SD 15 minutes] of triage) versus delayed (>75 minutes) administration of systemic corticosteroids on health outcomes...
  17. ncbi Expectations about and impact of the Liverpool Care Pathway for the dying patient in an Italian hospital
    Silvia Di Leo
    Regional Palliative Care Network National Cancer Research Institute, Largo R Benzi 10, 16132 Genoa, Italy
    Palliat Med 25:293-303. 2011
    ..LCP-I implementation may improve both knowledge about physical symptom management and professional awareness of the problems related to emotional and informative support in end-of-life care...
  18. ncbi Nurses' views on using the Liverpool care pathway in an acute hospital setting
    Tina O'Hara
    Cambridge University Hospitals NHS Trust
    Int J Palliat Nurs 17:239-44. 2011
    ..Exploring the effect of the LCP on patient care may provide valuable data that may inform how the LCP is integrated into practice in the future...
  19. ncbi Audit of the care of the dying in a network of hospitals and institutions in Queensland
    J R Hardy
    Mater Health Services, South Brisbane, Queensland, Australia
    Intern Med J 37:315-9. 2007
    ..g. acute hospitals and residential age-care facilities) by defining goals of best care, providing guidelines to provide that care and documenting outcome...
  20. ncbi Optimal clinical pathway for the patient with type B acute aortic dissection
    Tetsuya Niino
    Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
    Circ J 73:264-8. 2009
    ..The diameter of the aorta had not enlarged in either group 1 month later. Conclusions The clinical pathway of treatment for uncomplicated type B AAD was safer and better for preventing early complications and cost benefit...
  21. ncbi Effectiveness of a clinical pathway for the emergency treatment of patients with inborn errors of metabolism
    Dina J Zand
    Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Children s National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA
    Pediatrics 122:1191-5. 2008
    ..The goal was to measure the effectiveness of a clinical pathway for the emergency department care of patients with inborn errors of metabolism...
  22. ncbi Improving end-of-life care: development and pilot-test of a clinical pathway
    Marilyn Bookbinder
    Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, New York 10003, USA
    J Pain Symptom Manage 29:529-43. 2005
    ..Further study of this systems-oriented approach to change is warranted and should include direct assessment of patient and family outcomes, as well as measures of process...
  23. ncbi Reduced in-hospital mortality for heart failure with clinical pathways: the results of a cluster randomised controlled trial
    M Panella
    Department of Clinical and Experimental Medicine, Section of Public Health, Faculty of Medicine, University of Eastern Piedmont Amedeo Avogadro, 28100 Novara, Italy
    Qual Saf Health Care 18:369-73. 2009
  24. ncbi The benefits of using clinical pathways for managing acute paediatric illness in an emergency department
    G J Browne
    Department of Emergency Medicine, The Children s Hospital at Westmead, Royal Alexandra Hospital for Children, NSW, Australia
    J Qual Clin Pract 21:50-5. 2001
    ..Clinical pathways in this emergency department allowed rapid stabilisation of children, reducing admission rate, with a shortened length of hospital stay and few patients re-presenting after discharge and were well accepted by parents...
  25. ncbi 23-hour-stay laparoscopic colectomy
    B F Levy
    Department of Surgery, Minimal Access Therapy Training Unit, Post Graduate Medical School, University of Surrey, Guildford, Surrey, United Kingdom
    Dis Colon Rectum 52:1239-43. 2009
    ..The purpose of this study was to assess the acceptability and safety of a 23-hour-stay protocol developed for patients undergoing laparoscopic colectomy...
  26. ncbi Do pathways lead to better organized care processes?
    Kris Vanhaecht
    Center for Health Services and Nursing Research, Catholic University Leuven, Leuven, Belgium
    J Eval Clin Pract 15:782-8. 2009
  27. ncbi Key interventions and outcomes in joint arthroplasty clinical pathways: a systematic review
    Pieter Van Herck
    Centre for Health Services and Nursing Research, Catholic University Leuven, Kapucijnenvoer 35 4th floor, 3000 Leuven, Belgium
    J Eval Clin Pract 16:39-49. 2010 is aimed at three research questions: (1) What are the key interventions used in joint arthroplasty clinical pathways? (2) Which outcome measures are used? (3) What are the effects of a joint arthroplasty clinical pathway?..
  28. ncbi Feasibility and economic impact of a clinical pathway for pap test utilization in Gynecologic Oncology practice
    Antonio Santillan
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gynecol Oncol 109:388-93. 2008
    ..S. healthcare system of implementing a clinical pathway for Pap test utilization in screening and surveillance of gynecologic cancers in a university-based gynecologic oncology practice...
  29. ncbi A prospective, randomized, controlled trial of an emergency department-based atrial fibrillation treatment strategy with low-molecular-weight heparin
    Michael H Kim
    Division of Cardiology, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Ann Emerg Med 40:187-92. 2002
    ..We assess an alternative accelerated clinical pathway approach to the management of patients with newly diagnosed or new-onset atrial fibrillation (AF)...
  30. ncbi How do nurses, midwives and health visitors contribute to protocol-based care? A synthesis of the UK literature
    Irene Ilott
    Knowledge Translation Project Lead, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
    Int J Nurs Stud 47:770-80. 2010
    ..Documents such as protocols, clinical guidelines and care pathways underpin evidence-based practice throughout the world...
  31. ncbi Care pathways for acute stroke care and stroke rehabilitation: from theory to evidence
    Joseph Kwan
    Elderly Care Research Unit, University of Southampton, UK
    J Clin Neurosci 14:189-200. 2007
    ..Future developments, including electronic care pathways, patient pathways, and pre-hospital care pathways for hyperacute stroke, will be discussed...
  32. ncbi Quality toolbox: clinical pathways can improve core measure scores
    Jack D McCue
    University of California, San Francisco, CA, USA
    J Healthc Qual 31:43-50. 2009
    ..67.8%, p < .001). Scores for all 10 ACM components for CP-managed patients were better than Maryland state averages. Improvements were stable over a 3-year period of time...
  33. ncbi Reducing clinical variations with clinical pathways: do pathways work?
    M Panella
    Department of Medical Sciences, Section of Public Health, University of Eastern Piedmont A Avogadro, Novara, Italy
    Int J Qual Health Care 15:509-21. 2003
    ..To test clinical pathways in a variety of Italian health care organizations in 2000-2002 to measure performance in decreasing process and outcome variations...
  34. ncbi Standardize to excellence: improving the quality and safety of care with clinical pathways
    Paul Kurtin
    Rady Children s Hospital San Diego, 3020 Children s Way, MC 5064, San Diego, CA 92123, USA
    Pediatr Clin North Am 56:893-904. 2009
    ..Involving house staff enriches the scholarly components of pathway development while actively engaging them in the science and practice of quality improvement...
  35. pmc A cluster randomised trial to assess the impact of clinical pathways on AMI management in rural Australian emergency departments
    Leigh D Kinsman
    School of Rural Health, Monash University, Vic, Australia
    BMC Health Serv Res 9:83. 2009
  36. ncbi Effectiveness of clinical pathways for total knee and total hip arthroplasty: literature review
    Stephen Kim
    Robert B Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Boston University School of Public Health, Boston, Massachusetts, USA
    J Arthroplasty 18:69-74. 2003
    ..However, interpretation of these studies is complicated by substantial methodological limitations, particularly the use of historical controls and failure to account for length of stay in rehabilitation facilities...
  37. ncbi Clinical pathway for fractured neck of femur: a prospective, controlled study
    P F Choong
    Department of Orthopaedics, St Vincent s Hospital, Melbourne, Vic
    Med J Aust 172:423-6. 2000
    ..To assess outcomes of using a clinical pathway for managing patients with fractured neck of femur...
  38. ncbi A decade on: has the use of integrated care pathways made a difference in Lanarkshire?
    P Kent
    Change and Innovation Department, NHS Lanarkshire, UK
    J Nurs Manag 14:508-20. 2006
    ..2) This provides an update of integrated care pathway development in a changing environment within NHS Lanarkshire and examines some of the key factors for success...
  39. ncbi Staff perceptions of end-of-life care following implementation of the liverpool care pathway for the dying patient in the acute care setting: a New Zealand perspective
    Jean B Clark
    MidCentral Health, Palmerston North, New Zealand
    J Palliat Med 15:468-73. 2012
    ..We report on the post-implementation findings of a mixed methodology (survey and focus group [FG] forums) study into staff perceptions of EOL care following the pilot implementation of the LCP into two acute wards...
  40. pmc A clinical pathway to accelerate recovery after colonic resection
    L Basse
    Department of Surgical Gastroenterology and Anesthesiology, Hvidovre University Hospital, Denmark
    Ann Surg 232:51-7. 2000
    ..To investigate the feasibility of a 48-hour postoperative stay program after colonic resection...
  41. pmc Understanding implementation processes of clinical pathways and clinical practice guidelines in pediatric contexts: a study protocol
    Shannon D Scott
    Faculty of Nursing, University of Alberta, Edmonton, AB, Canada
    Implement Sci 6:133. 2011
    ..This study focuses on improving health outcomes for common paediatric acute health concerns by evaluating strategies that improve KT and reduce clinical practice variation...
  42. ncbi A clinical pathway in a post-anaesthesia care unit to reduce length of stay, mortality and unplanned intensive care unit admission
    Alain S Eichenberger
    Division of Anaesthesiology, Department of Anaesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, Geneva, Switzerland
    Eur J Anaesthesiol 28:859-66. 2011
    ..The immediate post-operative period is critical with regard to post-operative outcomes...
  43. ncbi Inpatient asthma clinical pathways for the pediatric patient: an integrative review of the literature
    Nancy Cantey Banasiak
    Yale University School of Nursing, New Haven, CT, USA
    Pediatr Nurs 30:447-50. 2004
    ..The purpose of this paper was to conduct an integrative literature review of studies using an inpatient clinical pathway for the management of pediatric asthma...
  44. ncbi Analysis of factors affecting operating time, postoperative complications, and length of stay for total knee arthroplasty: nationwide web-based survey
    Hideo Yasunaga
    Department of Health Management and Policy, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Orthop Sci 14:10-6. 2009
    ..This study aimed to clarify the impact of various factors on the operating time, postoperative complications, and length of stay (LOS) after total knee arthroplasty (TKA)...
  45. doi Reliable implementation of clinical pathways: what will it take-that is the question
    Jeffrey M Simmons
    J Pediatr 152:303-4. 2008
  46. ncbi Clinical pathway care improves outcomes among patients hospitalized for community-acquired pneumonia
    Loran D Hauck
    Adventist Health System, Orlando, FL, USA
    Ann Epidemiol 14:669-75. 2004
    ..To examine the impact of a unique evidence-based clinical pathway on six outcomes of care in patients hospitalized for community-acquired pneumonia (CAP)...
  47. ncbi Lean thinking: can it improve the outcome of fracture neck of femur patients in a district general hospital?
    T A Yousri
    Department of Trauma and Orthopaedics, The Heart of England Foundation Trust, Good Hope Hospital, Birmingham, UK
    Injury 42:1234-7. 2011
    ..Future prospective studies are, however, needed to reconfirm these results and to evaluate the components that are most critical to the success of the implemented framework...
  48. ncbi Which factors are important for the successful development and implementation of clinical pathways? A qualitative study
    Manuela De Allegri
    Department of Surgery, University Medical Centre Mannheim, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    BMJ Qual Saf 20:203-8. 2011
    ..Evidence underpinning successful development and implementation is sparse...
  49. ncbi Effects of introducing an integrated care pathway in an acute stroke unit
    Joseph Kwan
    Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Age Ageing 33:362-7. 2004
    ..We sought to evaluate the effects of introducing an integrated care pathway for acute stroke...
  50. ncbi Hospital discharge of respiratory-technology-dependent children: role of a dedicated respiratory care discharge coordinator
    Donna K Tearl
    Department of Respiratory Care Services, Alfred I duPont Hospital for Children, 1600 Rockland Road, PO Box 269, Wilmington, DE 19899, USA
    Respir Care 51:744-9. 2006
    ..A process using multiple respiratory therapists (RTs) to achieve this may not be efficient...
  51. ncbi The Liverpool Care Pathway in intensive care: an exploratory study of doctor and nurse perceptions
    Ruth Walker
    University of North Staffordshire, NHS Trust, United Kingdom
    Int J Palliat Nurs 16:267-73. 2010
    ..Education and adequate support was identified as being pivotal to the successful implementation of any type of LCP...
  52. ncbi Monitoring the care of lung cancer patients: linking audit and care pathways
    E Kaltenthaler
    School of Health and Related Research, University of Sheffield, UK
    J Eval Clin Pract 7:13-20. 2001
    ..The flexibility of this methodology allows it to be adapted readily to a variety of clinical situations and conditions...
  53. ncbi The role of a nurse case manager in implementing a critical pathway for infrainguinal bypass surgery
    M D Walsh
    University of Colorado Health Sciences Center, Denver, USA
    Jt Comm J Qual Improv 27:230-8. 2001
    ..CONCLUSIONS: Intervention by a nurse case manager facilitated implementation of a critical pathway for patients undergoing infrainguinal bypass surgery, especially by preventing patient deviations due to intrainstitutional factors...
  54. ncbi [The perioperative charge equivalence of radical prostatectomy with 1-year follow up since the diagnosis of prostate cancer]
    Shunichi Namiki
    Department of Urology, Tohoku University Graduate School of Medicine
    Hinyokika Kiyo 50:71-5. 2004
    ..By standardizing preoperative and postoperative management for patients undergoing radical prostatectomy, significant savings can be achieved toward shorter hospital stays and lower hospital costs...
  55. ncbi Pathway management in ambulatory wound care: defining local standards for quality improvement and interprofessional care
    Peter Hensen
    Department of Dermatology, University of Muenster, Von Esmarch Strasse 58, D 48149 Muenster, Germany
    Int Wound J 2:104-11. 2005
    ..Variances must be merely written down in detail. After 1 year in clinical practice, we state that the use of a clinical pathway for chronic wound management is an effective method of improving clinical processes and patient outcomes...
  56. ncbi Step by step development of clinical care pathways for older cancer patients: necessary or desirable?
    Maruscha de Vries
    Comprehensive Cancer Centre South, P O Box 231, 5600 AE Eindhoven, The Netherlands
    Eur J Cancer 43:2170-8. 2007
    ..This paper gives an overview of common problems in older cancer patients and addresses communication barriers through the development of clinical care pathways in geriatric oncology...
  57. ncbi Introducing an integrated care pathway for the last days of life
    Sally Mirando
    Herefordshire Primary Care Trust, Ross Community Hospital, Ross on Wye, UK
    Palliat Med 19:33-9. 2005
    ..Strikingly, a large number of patients dying from nonmalignant disease were cared for via the pathway, which was not expected...
  58. pmc Sustainability of healthcare improvement: what can we learn from learning theory?
    Einar Hovlid
    Institute of Social Science, Sogn og Fjordane University College, Postbox 133, 6851, Sogndal, Norway
    BMC Health Serv Res 12:235. 2012
    ..To identify factors contributing to sustainability of improvements, we use learning theory to explore a case that had displayed sustained improvement...
  59. ncbi A new approach to systematization of the management of paper-based clinical pathways
    Shunji Wakamiya
    Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    Comput Methods Programs Biomed 82:169-76. 2006
  60. ncbi An ontology-based hierarchical semantic modeling approach to clinical pathway workflows
    Yan Ye
    Department of Industrial Engineering and Logistics Management, Shanghai Jiao Tong University, Min Hang District, 200240 Shanghai, China
    Comput Biol Med 39:722-32. 2009
    ..An illustrative example about a clinical pathway for cesarean section shows the applicability of the proposed methodology in enabling structured semantic descriptions of any real clinical pathway...
  61. ncbi Design and impact of an intraoperative pathway: a new operating room model for team-based practice
    Bernard T Lee
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Coll Surg 207:865-73. 2008
    ..We describe development of an intraoperative pathway for deep inferior epigastric perforator (DIEP) flap breast reconstruction and its impact on various outcomes...
  62. ncbi Implications of decreasing surgical lengths of stay
    N Board
    Prince of Wales Hospital, Randwick
    Aust Health Rev 23:62-76. 2000
    ..Average costs per separation were at least $239 (herniorrhaphy) and $265 (laparoscopic cholecystectomy) lower for those on the DOSA pathway with domiciliary post acute care...
  63. ncbi Use of the proportion of patients dying on an End of Life Pathway as a quality marker: considerations for interpretation
    Edwin J Pugh
    Palliative Care, University of Teesside, Middlesbrough, UK
    Palliat Med 24:544-7. 2010
    ..This should be considered particularly when presenting the results to the public and to healthcare stakeholders or when making comparisons between provider organizations...
  64. ncbi [Evidence based guidelines and clinical pathways: complementation or contradiction?]
    M Lelgemann
    Ärztliches Zentrum für Qualität in der Medizin, Gemeinsame Einrichtung der Bundesärztekammer und der Kassenärztlichen Bundesvereinigung, Berlin
    Internist (Berl) 47:690, 692-7. 2006
    ..The article highlights methodological requirements in guideline and pathway development and gives prospects on how both tools can be used together...
  65. ncbi Effects of counseling and implementation of clinical pathway on diabetic patients hospitalized with hypoglycemia
    P Kampan
    Section of Medicine, Taksin Hospital, Bangkok, Thailand
    J Med Assoc Thai 89:619-25. 2006
    ..A prospective randomized controlled study was conducted to examine the effects of counseling and implementation of clinical pathway on type 2 diabetic patients hospitalized with hypoglycemia...
  66. ncbi An integrated care pathway for the last two days of life: Wales-wide benchmarking in palliative care
    Andrew Fowell
    North West Wales NHS Trust, Palliative Care Department, Bodfan, Eryri Hospital, Caernarfon, Wales
    Int J Palliat Nurs 8:566-73. 2002
    ..The same problems were experienced across acute, hospice, specialist inpatient units and community care. Closing the audit cycle involves incorporating the information from the variance analysis into clinical practice...
  67. ncbi Does the organization of care processes affect outcomes in patients undergoing total joint replacement?
    Kris Vanhaecht
    Center for Health Services and Nursing Research, School of Public Health, Faculty of Medicine, Catholic University Leuven, Kapucijnenvoer 35, 4th Floor, Leuven B 3000, Belgium
    J Eval Clin Pract 16:121-8. 2010
    ..Although evidence is available on the effect of pathways in total joint replacement, their impact with the organization of the care process has not been studied previously...
  68. ncbi The effects of the critical pathway for inguinal hernia repair
    Hye jin Joh
    The Catholic University of Korea College of Nursing, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
    Yonsei Med J 44:81-8. 2003
  69. ncbi Impact of IT-supported clinical pathways on medical staff satisfaction. A prospective longitudinal cohort study
    Jochen Schuld
    Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital of the Saarland, 66421 Homburg Saar, Germany
    Int J Med Inform 80:151-6. 2011
    ..Herein, we describe the effect of this new concept on medical staff satisfaction...
  70. pmc Qualitative evaluation of a local coronary heart disease treatment pathway: practical implications and theoretical framework
    Lena Kramer
    Department of General Practice Family Medicine, University of Marburg, Karl von Frisch Straße 4, 35043, Marburg, Germany
    BMC Fam Pract 13:36. 2012
  71. ncbi The implementation of an end-of-life integrated care pathway in a Chinese population
    S H Lo
    Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong
    Int J Palliat Nurs 15:384-8. 2009
    ..The acceptance of using the ECP as a standard clinical practice takes time and education. Appropriate template design and supervision are the keys to success...
  72. ncbi Role of scientific societies in implementation of stroke guidelines and clinical pathways promotion
    L Provinciali
    Department of Neurological Sciences, Ospedali Riuniti, Ancona, Italy
    Neurol Sci 27:S284-6. 2006
  73. ncbi The mastectomy clinical pathway: what has it achieved?
    U Santoso
    Division of General Surgery, National University Hospital, 5 Lower Kent Ridge Road, Kent Ridge Wing, Level 5, Singapore 119074
    Ann Acad Med Singapore 31:440-5. 2002
    ..The aim of this study was to prospectively assess the effect of the mastectomy pathway at the National University Hospital, Singapore over a 7-month period...
  74. ncbi Nurses' perceptions of the Liverpool Care Pathway for the dying patient in the acute hospital setting
    Barbara A Jack
    Edge Hill College School of Health Studies, University Hospital Aintree, Longmore Lane, Liverpool, L9 7AL, UK
    Int J Palliat Nurs 9:375-81. 2003
    ..The results suggest that the nurses have generally found that the LCP had a positive impact on patients, their families and also on nurses and doctors. This article will explore these benefits, as well as potential barriers to its use...
  75. ncbi Critical pathways: the role of pharmacy today and tomorrow
    Paul P Dobesh
    American College of Clinical Pharmacy, Kansas City, MO 64111, USA
    Pharmacotherapy 26:1358-68. 2006
  76. ncbi Enhancing hospital nurses' knowledge of palliative care: a network nurse programme
    Barbara A Jack
    Edge Hill College Faculty of Health, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Int J Palliat Nurs 10:502-6. 2004
    ..Support and networking opportunities were also identified. This article discusses the programme, the evaluation findings and makes suggestions for further research...
  77. ncbi A randomized controlled trial of an asthma clinical pathway for children in general practice
    E A Mitchell
    Department of Paediatrics, University of Auckland, New Zealand
    Acta Paediatr 94:226-33. 2005
    ..To evaluate the effect of the implementation of an asthma clinical pathway on asthma in children in general practice...
  78. ncbi The effect of the Liverpool Care Pathway for the dying: a multi-centre study
    Laetitia Veerbeek
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Palliat Med 22:145-51. 2008
    ..LCP use contributes to the quality of documentation and symptom control...
  79. pmc A cluster randomized controlled trial of a clinical pathway for hospital treatment of heart failure: study design and population
    Massimiliano Panella
    Department of Clinical and Experimental Medicine, University of Eastern Piedmont A, Avogadro, Novara, Italy
    BMC Health Serv Res 7:179. 2007
    ..The primary objective of the trial was to evaluate the effectiveness of the implementation of clinical pathways for hospital treatment of heart failure in Italian hospitals...
  80. ncbi Pathways to the diagnosis of colorectal cancer: an observational study in three UK cities
    Jacqueline Barrett
    Academic Unit of Primary Health Care, Department of Community Based Medicine, University of Bristol, The Grange, 1 Woodland Road, Bristol BS8 1AU, UK
    Fam Pract 23:15-9. 2006
    ..The route that has received most investment in the UK National Health Service is the 2-week clinic, but the proportions of patients taking this and other routes to diagnosis are largely unknown...
  81. pmc A cluster randomized trial to assess the impact of clinical pathways for patients with stroke: rationale and design of the Clinical Pathways for Effective and Appropriate Care Study [NCT00673491]
    Massimiliano Panella
    Department of Clinical and Experimental Medicine, University of Eastern Piedmont A, Avogadro, Novara, Italy
    BMC Health Serv Res 8:223. 2008
    ..The purpose of this study is to determine whether clinical pathways could improve the quality of the care provided to the patients affected by stroke in hospital and through the continuum of the care...
  82. ncbi The relationship between short-term mortality and quality of care for hip fracture: a meta-analysis of clinical pathways for hip fracture
    Mark D Neuman
    Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 57:2046-54. 2009
    ..To assess the association between use of clinical pathways for hip fracture and changes in the rates of five inpatient complications and short-term mortality...
  83. ncbi An evaluation of the impact of the ventilator care bundle
    Eddie Crunden
    Critical Care, Intensive Care Unit, East Surrey Hospital, Redhill, Surrey, UK
    Nurs Crit Care 10:242-6. 2005
    ..Since the introduction of the ventilator care bundle, length of ventilation and ICU LOS have reduced significantly...
  84. ncbi Effectiveness of a clinical pathway for inpatient asthma management
    K B Johnson
    Division of General Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3144, USA
    Pediatrics 106:1006-12. 2000
    ..Clinical pathways for asthma are tools that have the potential to improve compliance with nationally recognized management guidelines, but their effect on patient outcomes has not been documented...
  85. ncbi Toward improved implementation of evidence-based clinical algorithms: clinical practice guidelines, clinical decision rules, and clinical pathways
    Gary M Gaddis
    St Luke s Hospital of Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, MO, USA
    Acad Emerg Med 14:1015-22. 2007
    ..Consensus was reached that the majority of research efforts to evaluate means to improve KT need to be centered on the factors that show promise to enhance "getting the evidence used," focused especially on organizational factors...
  86. pmc What is a clinical pathway? Development of a definition to inform the debate
    Leigh Kinsman
    School of Rural Health, Monash University, Bendigo, Victoria, Australia
    BMC Med 8:31. 2010
    ..This paper describes efforts made by a team of Cochrane Review authors to develop criteria to assist in the objective identification of clinical pathway studies from the literature...
  87. ncbi An evidence-based clinical pathway for bronchiolitis safely reduces antibiotic overuse
    Stephen D Wilson
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Am J Med Qual 17:195-9. 2002
    ..Overall, the study suggests that implementation of a clinical pathway may be an effective means to change physician practice and reduce the unnecessary use of antibiotics, while maintaining or improving other aspects of quality of care...
  88. ncbi Prospective, randomized, controlled trial between a pathway of controlled rehabilitation with early ambulation and diet and traditional postoperative care after laparotomy and intestinal resection
    Conor P Delaney
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    Dis Colon Rectum 46:851-9. 2003
    ..Although several protocols have been reported to reduce postoperative stay, no Level I evidence exists for their use in routine clinical practice...
  89. pmc Facilitators and barriers to implementing clinical care pathways
    Sara Evans-Lacko
    Health Service and Population Research Department, Institute of Psychiatry, King s College London, De Crespigny Park, London SE58AF, UK
    BMC Health Serv Res 10:182. 2010
  90. ncbi Clinical effectiveness of an integrated care pathway for infants with bronchiolitis
    Sue Peter
    Princess Margaret Hospital, Perth, Western Australia
    Paediatr Nurs 16:30-5. 2004
  91. ncbi Effectiveness of a croup clinical pathway in the management of children with croup presenting to an emergency department
    R Chin
    Department of Emergency Medicine, The Children s Hospital at Westmead, Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia
    J Paediatr Child Health 38:382-7. 2002
    ..The aim of this study was to evaluate the safety and effectiveness of a clinical pathway for croup in an emergency department (ED)...
  92. ncbi Facilitating recovery: evidence for organized stroke care
    Lalit Kalra
    Department of Stroke Medicine, King s College London School of Medicine, London, UK
    J Rehabil Med 39:97-102. 2007
    ..Finally, some key challenges have been identified for stroke units in improving rehabilitation outcomes over the next decade and for healthcare planners in investing adequately in organized stroke services...
  93. ncbi The role of clinical uncertainty in treatment decisions for diabetic patients with uncontrolled blood pressure
    Eve A Kerr
    Center for Clinical Management Research, Veterans Affairs Ann Arbor Healthcare System and the University of Michigan Department of Internal Medicine, Ann Arbor, Michigan 48113 0170, USA
    Ann Intern Med 148:717-27. 2008
    ..Factors underlying failure to intensify therapy in response to elevated blood pressure have not been systematically studied...
  94. ncbi Development of a clinical pathway for total knee arthroplasty and the effect on length of stay and in-hospital functional outcome
    Kris Vanhaecht
    Centre for Health Services and Nursing Research, Faculty of Medicine, Catholic University Leuven, Belgium
    Acta Orthop Belg 71:439-44. 2005
    ..This pathway significantly decreased length of stay by 33% without negatively affecting functional outcomes during hospitalisation. In further research also the long-term effects have to be studied...
  95. ncbi Re-mapping client journeys and professional identities: a review of the literature on clinical pathways
    Billie Hunter
    School of Health Science, Swansea University, Singleton Park, Swansea SA2 8PP, UK
    Int J Nurs Stud 45:608-25. 2008
    ..To explore the growing use of clinical pathways by nurses and midwives, their impact on client care, and the potential consequences of widespread pathway utilisation for the professional identity and knowledge base of nursing and midwifery...
  96. ncbi Critical pathways: effectiveness in achieving patient outcomes
    C L Ireson
    University of Kentucky Hospital, Lexington, USA
    J Nurs Adm 27:16-23. 1997 differs from previous critical pathway trials in that an objective measure of quality was used and the critical pathways were not introduced concurrently with a case management delivery model...
  97. ncbi Critical pathways for postoperative care after simple congenital heart surgery
    M B Price
    Primary Childrens Medical Center, Salt Lake City, UT, USA
    Am J Manag Care 5:185-92. 1999
    To evaluate the clinical, financial, and parent/patient satisfaction impact of critical pathways on the postoperative care of pediatric cardiothoracic patients with simple congenital heart lesions.
  98. ncbi Development and validation of a care process self-evaluation tool
    Kris Vanhaecht
    Centre for Health Services and Nursing Research, School of Public Health, Catholic University Leuven, Leuven, Belgium
    Health Serv Manage Res 20:189-202. 2007
    ..The CPSET can be used in the audit and accreditation of care processes and will help managers and clinicians to understand better how care processes are organized...
  99. ncbi Care pathways: a legal sword or shield?
    Richard Griffith
    School of Health Science, Swansea University
    Br J Community Nurs 12:374-7. 2007
    ..In this article Richard Griffith considers the legal implications of care pathways...
  100. pmc Critical pathway effectiveness: assessing the impact of patient, hospital care, and pathway characteristics using qualitative comparative analysis
    Sydney M Dy
    Maryland Community Hospice, Room 609, 624N Broadway, Baltimore, MD 21205, USA
    Health Serv Res 40:499-516. 2005
    ..To qualitatively describe patient, hospital care, and critical pathway characteristics that may be associated with pathway effectiveness in reducing length of stay...
  101. ncbi Success of clinical pathways for total joint arthroplasty in a community hospital
    Frank L Walter
    Department of Orthopaedics, Wayne State University, Warren, MI, USA
    Clin Orthop Relat Res 457:133-7. 2007
    ..We recommend clinical pathways for patients having total joint arthroplasties to reduce length of stay, facilitate effective resource use, and preserve quality of care without compromising patient satisfaction or safety...

Research Grants70

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..Liver-based metabolic disease can result from mutations in genes in these critical pathways. Transgenic or knock-out mouse models have been created for many of these diseases, but they do not always ..
  2. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010 life is through epigenetic effects on somatic cells, leading to activation or silencing of key genes in critical pathways. DNA methylation, one type of epigenetic change, may play an important role in disease causation by altering ..
  3. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    Project Summary Our goal is to understand the potential independent and combined contributions of several critical pathways for human development to risks of orofacial clefts...
  4. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..into the role of ES in male fertility and a better understanding of the mechanisms by which defects in these critical pathways lead to infertility...
  5. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ..studies we found that both RANKL and MIP-1d were capable of stimulating NF-?B and PLC?2 signaling, two critical pathways for OCL formation, while other important pathways in OCL formation were unaffected by MIP-1d...
  6. The role of plasmacytoid dendritic cells in corneal immunity
    Pedram Hamrah; Fiscal Year: 2013
    ..Identifying specific functions of pDC in HSK and understanding the critical pathways of pDC and T cell migration in the cornea may provide new molecular targets for pharmacological intervention ..
  7. The Role of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal Dys
    Ula V Jurkunas; Fiscal Year: 2013
    ..stress causes molecular and cellular damage in susceptible human corneal endothelial cells and which critical pathways specifically lead to progressive endothelial cell apoptosis and degeneration...
  8. Aging Oxidative Stress and Microglia
    Paula C Bickford; Fiscal Year: 2013
    ..This will inform us as to critical pathways to target for the development of new interventions to improve cognitive aging.
  9. control of Inflammation by regulatory T cells and BCL6
    Alexander L Dent; Fiscal Year: 2012
    ..The transcriptional repressor, BCL6, regulates several critical pathways of the immune system and acts as an oncogene in B cells...
  10. Inhibition of Histone Deacetylase in Myeloproliferative Neoplasms
    Golam Mohi; Fiscal Year: 2012
    ..Therefore, identifying additional therapies targeting JAK2V617F or MPLW515L or critical pathways downstream of JAK2V617F/MPLW515L would be beneficial for the treatment of MPNs...
  11. Genetic regulation of racial differences in platelet reactivity
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013
    ..The goals of this application are to characterize 1) the critical pathways and proteins responsible for these racial differences in platelet function, and 2 the molecular genetic ..
  12. Biological Response to Air Quality Change in Beijing pre-, mid- and post-Olympics
    Lina Mu; Fiscal Year: 2013 investigate the acute biological response to changes in human exposure to PM and to better understand the critical pathways through which PM operates in these diseases...
  13. Regulation of yeast cellular aging through chromatin and novel pathways
    Weiwei Dang; Fiscal Year: 2013
    ..difficult to explorer more pro-lifespan regulators, like Sir2, because disruption of many genes that impair critical pathways naturally result in shorter lifespan and they may not be directly involved in aging regulation...
  14. Syk and associated proteins in breast cancer
    Robert L Geahlen; Fiscal Year: 2011
    ..the malignant phenotype of breast cancer cells is of considerable importance to our understanding of the critical pathways involved in growth control in breast epithelial cells and to the identification of possible, novel ..
  15. Optimizing Therapeutic Revascularization by Endothelial Cell Transplantation
    W Mark Saltzman; Fiscal Year: 2013
    ..In Aim 1, we seek to improve EC function by identifying and engaging critical pathways mediated by Bcl-2...
  16. Generation and validation of a comprehensive human disease mutant ORF resource
    Luke J Whitesell; Fiscal Year: 2010
    ..The never before achievable insights will dramatically improve the translation of current genetic knowledge to actual improvements in treatment and outcome for patients. ..
    Frank D Gilliland; Fiscal Year: 2013
    ..the genes and exposures related to lung function and asthma, the common susceptibility factors and critical pathways underlying these pathological processes are not well understood...
  18. Role of a Novel Homeobox Transcription Factor (HLX) in Acute Myeloid Leukemia
    Ulrich G Steidl; Fiscal Year: 2013
    ..of HLX inhibition in primary human AML cells and a genetic mouse model of AML, and identify functionally critical pathways which mediate the leukemia-inhibitory effect of HLX downregulation...
  19. Genes, Air Pollution, Oxidant Stress, Inflammation and Children's Resp
    Frank D Gilliland; Fiscal Year: 2011
    ..and lung function, more research is needed to understand the role of genetics in susceptibility and identify critical pathways and vulnerable populations for interventions...
  20. A Study of Trends in Obesity Progression among Complex Patients
    Ming Tai Seale; Fiscal Year: 2010
    ..Results of the study can inform current local and national quality improvement measures and treatment guidelines for managing patients with this common and costly constellation of priority conditions. ..
  21. SOX9 in prostate cancer development and progression
    Xin Yuan; Fiscal Year: 2012
    ..hedgehog (Hh), and androgen signaling pathways, suggesting SOX9 may be an important mediator of these critical pathways for prostate development and homeostasis, and for PCa growth and progression...
  22. Comparative functional genomics for lung cancer gene discovery
    ..The overall goal of our work is to begin to define critical pathways that are required for genotype-specific oncogenesis...
  23. Differential Impact of Resveratrol and Resveratrol Mimetics Upon Aging Bone
    Bruce R Troen; Fiscal Year: 2013
    ..Hypothesis and Specific Aims: We hypothesize that SyRMs inhibit critical pathways of osteoclast formation and function involving c-Src phosphorylation, Rho GTPase activation, and NFATc1 ..
    Frank G Oppenheim; Fiscal Year: 2012
    ..Integration of the results from both proteomic and genetics approaches will allow us to identify the critical pathways of the histatin killing mechanism...
  25. Exploring Kabuki Syndrome as a Treatable Cause of Intellectual Disability
    Hans Tomas Bjornsson; Fiscal Year: 2013
    ..the hypothesis that the gene families found to be down-regulated in these two diseases cluster in several critical pathways shared by the two disorders...
  26. wnt Signaling in Liver Development and Disease
    Wolfram Goessling; Fiscal Year: 2009
    Liver disease is a common cause for morbidity and mortality in the U.S., and understanding the critical pathways during liver development is essential for our knowledge of normal liver function and disease...
  27. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..transcriptional activator that stimulates HTLV-1 viral gene expression and contributes to deregulation of critical pathways in the infected cell...
  28. Development of an activity based probe family for metallo aminopeptidases
    Doron Greenbaum; Fiscal Year: 2010
    ..Peptidases participate in several critical pathways during the life cycle of P...
    DAVID CY BEEBE; Fiscal Year: 2013
    ..This method will be used to inactivate critical pathways known to function in other adult stem cells...
    John F DiPersio; Fiscal Year: 2013
    ..We propose to use G-CSF plus AMD3100 as well as other novel small molecule inhibitors of three critical pathways associated with homing of AML blasts to the bone marrow thus rendering these cells more sensitive to ..
  31. Arterial Dysfunction: Basic and Clinical Mechanisms
    Thomas Michel; Fiscal Year: 2013
    ..of pathophysiological mechanisms of endothelial cell metabolism and oxidative stress that modify critical pathways in endothelial cells leading to arterial dysfunction...
  32. Calcium Regulation in Osteoclasts
    Leonidas Tsiokas; Fiscal Year: 2013
    ..Our studies will lead to further understanding of critical pathways in the regulation of osteoclast development and function, which is needed to identify and develop new ..
  33. Cancer Proteome Center at Washington Univ, Univ of North Carolina
    ROBERT REID TOWNSEND; Fiscal Year: 2013
    ..The causes of many cancers are somatic mutations in critical pathways that serve organ growth and metabolism...
  34. Trk Expression and Inhibition in Human Neuroblastomas
    Garrett M Brodeur; Fiscal Year: 2012
    ..responses;and analyze gene expression patterns induced by ligand activation of TrkA or TrkB to identify critical pathways that contribute to favorable and unfavorable behaviors, respectively...
  35. Role of Chromatin and ATP-dependent Remodeling on DNA DSB Processing
    NICHOLAS LEONARD ADKINS; Fiscal Year: 2012
    ..Repair of DNA through homologous recombination is one of the critical pathways in the maintenance of genomic integrity which has been shown to influence several pathological human ..
    MARIE HANIGAN; Fiscal Year: 2009
    ..of GGT are observed in the serum of patients with HCC indicates that GGT may be a reporter of changes in critical pathways that provide the tumor cell with a selective growth advantage during tumor formation or progression...
  37. Nucleosides and TREM2 Mediate Inflammation-Induced Bone Loss
    George Pan; Fiscal Year: 2010
    ..interrupting cytokines does not completely arrest the bone erosion implying the existence of other critical pathways for bone resorption...
  38. Premature Aging, Vascular Disease and Endothelial Mechanotransduction
    WILLIAM JAMES ADAMS; Fiscal Year: 2012
    ..into the pathogenesis of atherosclerosis, premature aging syndromes may offer an opportunity to expose new critical pathways involved in atherogenesis...
  39. Hsp90 Regulates EphA2 Signaling and Cell Migration in Glioblastoma
    Jennifer S Isaacs; Fiscal Year: 2012
    ..Collectively, these studies will shed light on critical pathways involved in GBM cell migration and will potentially lead to rational molecular-targeted therapeutic ..
  40. Mechanisms of B Cell-Dependent Transplantation Tolerance
    James F Markmann; Fiscal Year: 2011
    ..lines deficient in TIM-1 and TIM-4 expression to probe the possibility that TIM-1 and its ligand TIM-4 mark critical pathways in Breg-mediated tolerance...
  41. EGR-1: Regulator of apoptosis and inflammation in COPD
    Augustine M Choi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Our approach in elucidating critical pathways involved in the pathogenesis of human COPD has been to identify candidate genes from a comprehensive study of regulated genes in human lung tissues of ..
  42. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..The overall goal of this proposal is to examine critical pathways resulting in dysregulation of airway fibroblast growth and matrix expression throughout the lung that lead ..
  43. Chemical Probes and Chaperone-Accelerated Turnover of Tau
    Jason E Gestwicki; Fiscal Year: 2013
    ..The long-term goal of this work is to find new ways of treating AD and other tauopathies by understanding the critical pathways that control tau turnover.
  44. Biology and Therapy of High Risk Neuroblastoma
    ROBERT CHARLES SEEGER; Fiscal Year: 2013
    ..patients with refractory or recurrent disease will result from new combinatorial therapies that target critical pathways of tumor and host cells that promote neuroblastoma growth and survival in primary and metastatic sites...
  45. Exploiting Biological Networks to Improve Clinical Treatment of Ovarian Cancer
    Andrew K Godwin; Fiscal Year: 2013 single agents will not work in this disease and thus second site lethality screens will help identify critical pathways to target in combination with novel biologics...
  46. Bioinformatics and Population Genetics to Identify Rheumatoid Arthritis Genes
    Soumya Raychaudhuri; Fiscal Year: 2012
    ..identification of these genes has implications for (1) the rapid identification and diagnosis of RA, (2) recognizing critical pathways in the pathogenesis of the disease, and (3) defining future pharmaceutical targets.
  47. Translational Research of Negative Emotions and Acute Endothelial Dysfunction
    Daichi Shimbo; Fiscal Year: 2013
    ..Examination of these critical pathways will help determine whether endothelial dysfunction is a biological mechanism linking the experience of core ..
  48. Epithelial-mesenchymal Transition in the Pathogenesis of Pulmonary Fibrosis
    William E Lawson; Fiscal Year: 2010
    ..Defining the role of EMT in the lung and delineating critical pathways involved in this cellular plasticity could lead to novel therapeutic strategies to limit disease progression ..
  49. (IND 102,133) Inhibition of Aurora Kinase A as Treatment For Melanoma
    Jeffrey A Sosman; Fiscal Year: 2013
    ..success of therapy targeted at specific signaling pathways in other cancers, has intensified the search for critical pathways in melanoma , with potential targets already identified...
  50. Causal Estimates of Neighborhood Poverty on Health and Mortality
    D Phuong Do; Fiscal Year: 2010
    ..Adjusting for these factors eliminate possible critical pathways through which neighborhoods affect health, likely yielding overly conservative estimates of neighborhood ..
  51. Regulation of hematopoietic stem cell maintenance and survival by NKAP
    Virginia Smith Shapiro; Fiscal Year: 2013
    ..of genes downstream of NKAP that are required for HSC maintenance and survival Specific Aim 3: Defining the critical pathways regulated by NKAP in HSCs through identification of the protein-protein domains and associations required ..
  52. Novel Role of Ref-1 in Pancreatic Cancer Etiology and Progression
    Mark R Kelley; Fiscal Year: 2013
    ..The long-term goal of this work is to understand the critical pathways for survival and metastasis of pancreatic ductal adenocarcinoma (PDAC) and develop a therapy that improves ..
  53. Modulation of Endothelial Cell Function by the Shear Stress-Responsive miR-155
    Charles D Searles; Fiscal Year: 2013
    ..We will test the influence of miR- 155 on these critical pathways by experimentally manipulating expression of miR-155, its target gene, or members of the pathway that are ..
  54. Genomics of Lupus
    JOHN BARKER HARLEY; Fiscal Year: 2013
    ..developed ability to scan the entire genome provides an unprecedented opportunity for novel discovery of critical pathways in disease pathogenesis...
  55. Developmental neurotoxicity pathways for high throughput testing by metabolomics
    Thomas Hartung; Fiscal Year: 2012
    ..genomics approaches, a systems toxicology approach shall be applied now, in order to identify and validate critical pathways of toxicity (PoT)...
  56. The human B cell toll-like receptor 4 complex
    Lisa M Ganley-Leal; Fiscal Year: 2013
    ..The data generated in this proposal will have direct clinical relevance by identifying critical pathways for the development of improved treatments that change the course of disease...
  57. Characterization of an animal model of chronic infection and disease
    Linda F van Dyk; Fiscal Year: 2010
    ..will set the stage for future studies to define the genetic and environmental risks for these tumors, the viral and host contributors to tumor progression, and the critical pathways that could be disrupted for successful therapies.
  58. Methadone and HIV drug interactions
    Evan D Kharasch; Fiscal Year: 2012 methadone pharmacodynamics and clinical effects, and the influence of antiretrovirals on those critical pathways. A concerted clinical and translational approach to these aims will be pursued...
  59. Hemodynamics and Vascular Wall Biology Determine Arteriovenous Fistula Maturation
    Prabir Roy-Chaudhury; Fiscal Year: 2013
    ..vascular wall properties with the AVF outcomes should lead to novel predictors of AVF maturation, elucidate critical pathways to AVF failure, and point towards innovative therapies supporting successful maturation by targeting these ..
  60. Structural biology of oncogenic receptor tyrosine kinases
    Xiaolin He; Fiscal Year: 2010
    ..Growth factors signaling through the cell-surface receptor tyrosine kinases (RTKs) represent one of the most critical pathways in the cellular and inter-cellular regulation of vertebrate biological systems...
  61. Mechanisms of Fetal Myocardial and Coronary Growth Synchrony
    SONNET SKY JONKER; Fiscal Year: 2013
    ..Molecular and enzyme assays will be called upon to determine how critical pathways are regulating fetal coronary growth...
  62. Autophagy regulation of RSV-induced pulmonary disease
    Nicholas W Lukacs; Fiscal Year: 2013
    ..these investigations will be able to thoroughly characterize the mechanistic changes associated with these critical pathways. Thus, these studies will explore several novel and topical pathways that can not only further define the ..
    Thomas Scholz; Fiscal Year: 2001
    ..The malate/aspartate (mal/asp) and alpha- glycerophosphate (alpha-GP) shuttles, critical pathways for oxidation of cytosolic NADH in the neonatal heart, decline significantly after birth...
  64. Tool to Define the Antiproliferative Effects of Agmatine
    Joseph Satriano; Fiscal Year: 2006 of antiproliferative responses elicited by agmatine would allow us to define, target and exploit critical pathways by molecular or pharmacologic approaches...
    Caroline Zeiss; Fiscal Year: 2007 that despite differing genetic etiologies, mechanisms of neuronal degeneration converge upon common critical pathways. Identification of such pathways would advance understanding of neuronal homeostasis and is a prerequisite ..
  66. Immune Dysregulation in Allergic Asthma
    Mary Lipscomb; Fiscal Year: 2006
    ..Collectively, the four projects will identify mechanisms involved in critical pathways that lead to asthmatic lung inflammation and bronchial remodeling with the goal of identifying possible ..
    ALBERT BALDWIN JR; Fiscal Year: 2003
    ..These experiments will provide new insight into mechanisms whereby TNFalpha initiates and controls critical pathways involved in mediating inflammatory, proliferative and apoptotic functions.
  68. Hedgehog pathway in periosteum-mediated repair and regeneration
    Xinping Zhang; Fiscal Year: 2010
    ..The long-term goal of our project is to identify critical pathways and mechanisms for bone repair and reconstruction...
    JASON YUAN; Fiscal Year: 1999
    ..channels in HPV by using patch clamp techniques and fluorescent imaging microscopy in order to identify the critical pathways leading to HPV...
  70. Collaborative Study of Genetics of Dizygotic Twinning
    Grant Montgomery; Fiscal Year: 2006
    ..genes that make substantial contributions to variation in natural dizygotic (DZ) twinning to understand critical pathways controlling female fertility...