risk assessment

Summary

Summary: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Top Publications

  1. ncbi Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
  2. pmc A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    Stephen S Lim
    Institute for Health Metrics and Evaluation, Seattle, WA 98121, USA
    Lancet 380:2224-60. 2012
  3. doi General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
  4. pmc Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, 801 Massachusetts Ave, Boston, MA 02118, USA
    Stat Med 30:11-21. 2011
  5. ncbi Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
    B F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 285:2864-70. 2001
  6. doi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
  7. ncbi 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension
    Judith A Whitworth
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Hypertens 21:1983-92. 2003
  8. pmc Assessing the performance of prediction models: a framework for traditional and novel measures
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Epidemiology 21:128-38. 2010
  9. ncbi The diabetes risk score: a practical tool to predict type 2 diabetes risk
    Jaana Lindström
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:725-31. 2003
  10. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010

Detail Information

Publications357 found, 100 shown here

  1. ncbi Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
    ..We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers...
  2. pmc A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    Stephen S Lim
    Institute for Health Metrics and Evaluation, Seattle, WA 98121, USA
    Lancet 380:2224-60. 2012
    ..No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time.
  3. doi General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
    ..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
  4. pmc Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, 801 Massachusetts Ave, Boston, MA 02118, USA
    Stat Med 30:11-21. 2011
    ..We recommend that researchers clearly define and justify the choices they make when choosing NRI for their application...
  5. ncbi Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
    B F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 285:2864-70. 2001
    ..Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions...
  6. doi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
    ..Thus, many potential risk factors have not been included...
  7. ncbi 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension
    Judith A Whitworth
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Hypertens 21:1983-92. 2003
    ....
  8. pmc Assessing the performance of prediction models: a framework for traditional and novel measures
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Epidemiology 21:128-38. 2010
    ..Other measures of performance may be warranted in specific applications, such as reclassification metrics to gain insight into the value of adding a novel predictor to an established model...
  9. ncbi The diabetes risk score: a practical tool to predict type 2 diabetes risk
    Jaana Lindström
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:725-31. 2003
    ..Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes Risk Score...
  10. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  11. pmc Neonicotinoids in bees: a review on concentrations, side-effects and risk assessment
    Tjeerd Blacquière
    Plant Research International, Wageningen University and Research, Wageningen, The Netherlands
    Ecotoxicology 21:973-92. 2012
    ..for sublethal effects, and (3) the usefulness for the evaluation of neonicotinoids of an already existing risk assessment scheme for systemic compounds...
  12. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
    ..Concern exists regarding whether these functions can be generalized to other populations...
  13. doi The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    Salvatore Mottillo
    Jewish General Hospital McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1113-32. 2010
    ....
  14. pmc Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    M R Law
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 338:b1665. 2009
    ..To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment...
  15. doi A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    Ron Pisters
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:1093-100. 2010
    ..We aimed to develop a practical risk score to estimate the 1-year risk for major bleeding (intracranial, hospitalization, hemoglobin decrease > 2 g/L, and/or transfusion) in a cohort of real-world patients with AF...
  16. pmc Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    JAMA 308:788-95. 2012
    ....
  17. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
    ..Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention...
  18. ncbi Predictors of hospital mortality in the global registry of acute coronary events
    Christopher B Granger
    Division of Cardiology, University Medical Center, Durham, NC, USA
    Arch Intern Med 163:2345-53. 2003
    ..Management of acute coronary syndromes (ACS) should be guided by an estimate of patient risk...
  19. ncbi The use of fractional polynomials to model continuous risk variables in epidemiology
    P Royston
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
    Int J Epidemiol 28:964-74. 1999
    ..The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved...
  20. ncbi Use and misuse of the receiver operating characteristic curve in risk prediction
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circulation 115:928-35. 2007
    ..As novel risk factors are discovered, sole reliance on the c statistic to evaluate their utility as risk predictors thus seems ill-advised...
  21. pmc Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis
    F G R Fowkes
    JAMA 300:197-208. 2008
    ..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
  22. doi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  23. ncbi The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    E M Antman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 284:835-42. 2000
    ..Patients with unstable angina/non-ST-segment elevation myocardial infarction (MI) (UA/NSTEMI) present with a wide spectrum of risk for death and cardiac ischemic events...
  24. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  25. ncbi Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    Mary Claire King
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 302:643-6. 2003
    ..Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset...
  26. ncbi Tutorial in biostatistics: competing risks and multi-state models
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Stat Med 26:2389-430. 2007
    ..Examples of analysis with standard software are shown...
  27. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  28. pmc Exposure measurement error in time-series studies of air pollution: concepts and consequences
    S L Zeger
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 108:419-26. 2000
    ..Finally, we summarize open questions regarding measurement error and suggest the kind of additional data necessary to address them...
  29. doi Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    William H Geerts
    Thromboembolism Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Chest 133:381S-453S. 2008
    ..We recommend that, on admission to the ICU, all patients be assessed for their risk of VTE, and that most receive thromboprophylaxis (Grade 1A)...
  30. ncbi Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
    Alberto Papi
    Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1114-21. 2006
    ..Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial...
  31. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  32. pmc Effect of direct-to-consumer genomewide profiling to assess disease risk
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Translational Science Institute, and Scripps Health, La Jolla, CA 92037, USA
    N Engl J Med 364:524-34. 2011
    ..We examined the psychological, behavioral, and clinical effects of risk scanning with the Navigenics Health Compass, a commercially available test of uncertain clinical validity and utility...
  33. ncbi From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1664-72. 2003
    ..3) A quantitative method for cumulative risk assessment of vulnerable patients needs to be developed that may include variables based on plaque, blood, and ..
  34. pmc Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study
    Julia Hippisley-Cox
    Tower Building, University Park, Nottingham NG2 7RD
    BMJ 335:136. 2007
    ..To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN)...
  35. doi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
    ..Therefore, measures should be put in place to reduce exposure to a minimum, and the tolerably daily intake should be set in accordance with recent findings...
  36. doi Polygenes, risk prediction, and targeted prevention of breast cancer
    Paul D P Pharoah
    Department of Oncology, University of Cambridge, United Kingdom
    N Engl J Med 358:2796-803. 2008
    ..New developments in the search for susceptibility alleles in complex disorders provide support for the possibility of a polygenic approach to the prevention and treatment of common diseases...
  37. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  38. ncbi Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study
    Jing Liu
    Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
    JAMA 291:2591-9. 2004
    ..Recalibration of Framingham functions could permit various regions of the world to adapt Framingham tools to local populations...
  39. ncbi Increasing prevalence of the metabolic syndrome among u.s. Adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 27:2444-9. 2004
    ..The prevalence of the metabolic syndrome is high among U.S. adults. Our purpose was to determine whether the prevalence of this syndrome has changed since 1988-1994...
  40. pmc Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women
    Wei Zheng
    Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 102:972-81. 2010
    ..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer ..
  41. ncbi Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    N Engl J Med 356:2457-71. 2007
    ..Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been determined...
  42. ncbi Diabetes mellitus and risk of colorectal cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 97:1679-87. 2005
    ..To resolve these inconsistencies, we conducted a meta-analysis of published data on the association between diabetes and the incidence and mortality of colorectal cancer...
  43. ncbi TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudy
    D A Morrow
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 102:2031-7. 2000
    ..Complex multivariable models identify independent predictors and quantify their relative contribution to mortality risk but are too cumbersome to be readily applied in clinical practice...
  44. doi Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Daniel E Singer
    Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 133:546S-592S. 2008
    ..However, in patients without contraindications to anticoagulation, we suggest beginning IV heparin or LMWH at presentation (Grade 2C)...
  45. ncbi Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
    ..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations...
  46. pmc Carotid-wall intima-media thickness and cardiovascular events
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    N Engl J Med 365:213-21. 2011
    ..Intima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events...
  47. pmc Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 339:b4229. 2009
    ..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
  48. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    ..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
  49. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  50. pmc Insulin resistance increases the occurrence of new cardiovascular events in patients with manifest arterial disease without known diabetes. the SMART study
    Sandra N Verhagen
    Department of Vascular Medicine, University Medical Centre Utrecht, The Netherlands
    Cardiovasc Diabetol 10:100. 2011
    ....
  51. pmc Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Natl Cancer Inst 103:1252-63. 2011
    ..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
  52. ncbi Gender differences in the metabolic syndrome and their role for cardiovascular disease
    V Regitz-Zagrosek
    Center for Gender in Medicine and Cardiovascular Disease in Women, Charite and Deutsches Herzzentrum Berlin, Germany
    Clin Res Cardiol 95:136-47. 2006
    ....
  53. pmc Atherosclerosis
    A J Lusis
    Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA
    Nature 407:233-41. 2000
    ..It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis...
  54. pmc A cohort study of traffic-related air pollution impacts on birth outcomes
    Michael Brauer
    School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
    Environ Health Perspect 116:680-6. 2008
    ..Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts...
  55. ncbi The use of receiver operating characteristic curves in biomedical informatics
    Thomas A Lasko
    Decision Systems Group, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biomed Inform 38:404-15. 2005
    ..In this article, we review the basic concepts of ROC analysis, illustrate their use with sample calculations, make recommendations drawn from the literature, and list readily available software...
  56. ncbi A physiological profile approach to falls risk assessment and prevention
    Stephen R Lord
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, New South Wales, 2031, Australia
    Phys Ther 83:237-52. 2003
    The purpose of this perspective article is to describe the use of a physiological profile approach to falls risk assessment and prevention that has been developed by the Falls and Balance Research Group of the Prince of Wales Medical ..
  57. doi Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment
    Gerald T Ankley
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 29:730-41. 2010
    ..a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment. The practical utility of AOPs for ecological risk assessment of chemicals is illustrated using five case ..
  58. pmc Adherence to Mediterranean diet and health status: meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    BMJ 337:a1344. 2008
    ..To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting...
  59. pmc 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations
    Jacques Genest
    McGill University Health Centre, Montreal, Canada
    Can J Cardiol 25:567-79. 2009
    ..The present article represents the 2009 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult...
  60. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
    ..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
  61. doi Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
    J Intern Med 267:89-105. 2010
    ..Even without being able to perform a quantitative risk assessment for ENMs, due to the lack of sufficient data on exposure, biokinetics and organ toxicity, until we know ..
  62. pmc Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies
    A Antoniou
    Cancer Research U K Genetic Epidemiology Unit, Department of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 72:1117-30. 2003
    ..The variation in risk by age at diagnosis of index case is consistent with the effects of other genes modifying cancer risk in carriers...
  63. pmc Pharmaceuticals and personal care products in the environment: what are the big questions?
    Alistair B A Boxall
    Environment Department, University of York, Heslington, York, United Kingdom
    Environ Health Perspect 120:1221-9. 2012
    ..Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment...
  64. pmc Novel and conventional biomarkers for prediction of incident cardiovascular events in the community
    Olle Melander
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
    JAMA 302:49-57. 2009
    Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment.
  65. pmc Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
    Carl Elis Boström
    Swedish Environmental Protection Agency, Stockholm, Sweden
    Environ Health Perspect 110:451-88. 2002
    ..Additional source-specific indicators are benzo[ghi]perylene for gasoline vehicles, retene for wood combustion, and dibenzothiophene and benzonaphthothiophene for sulfur-containing fuels...
  66. pmc Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reporting
    Gary S Collins
    Centre for Statistics in Medicine, University of Oxford, Wolfson College Annexe, Oxford, OX2 6UD, UK
    BMC Med 9:103. 2011
    ....
  67. doi EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high-risk patients in general practice: cross-sectional survey in 12 European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Eur J Cardiovasc Prev Rehabil 17:530-40. 2010
    ..To determine whether the 2003 Joint European Societies' guidelines on cardiovascular disease prevention in people at high cardiovascular risk have been followed in general practice...
  68. pmc The association between glucometabolic disturbances, traditional cardiovascular risk factors and self-rated health by age and gender: a cross-sectional analysis within the Malmö Preventive Project
    Margret Leosdottir
    Department of Cardiology, Skane University Hospital, and Heart Health Group Department of Clinical Sciences, Lund University, Malmo, Sweden
    Cardiovasc Diabetol 10:118. 2011
    ..Whether this age-related reduction applies to CVD risk factors, and whether it is limited to established diabetes mellitus (DM) or also applies to pre-diabetic conditions are not well known...
  69. pmc Cardiometabolic risk variables in overweight and obese children: a worldwide comparison
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:106. 2011
    ..The results of our review present a fair estimation of the true differences between cardiometabolic risk profiles among pediatric cohorts worldwide, based on available literature...
  70. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  71. ncbi Cancer statistics, 2007
    Ahmedin Jemal
    Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 57:43-66. 2007
    ..Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population...
  72. ncbi Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
    ..This paper describes the pilot evaluation of the CAARMS...
  73. doi Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascula
    James H Stein
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
  74. pmc Life course epidemiology
    D Kuh
    Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, University College London and Royal Free Medical School, Gower Street Campus, 1 19 Torrington Place, London WC1E 6BT, U K
    J Epidemiol Community Health 57:778-83. 2003
  75. ncbi Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
    ..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
  76. ncbi Meta-analysis of the relationship between risk perception and health behavior: the example of vaccination
    Noel T Brewer
    Department of Health Behavior and Health Education, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Health Psychol 26:136-45. 2007
    ..Risk perceptions are central to many health behavior theories. However, the relationship between risk perceptions and behavior, muddied by instances of inappropriate assessment and analysis, often looks weak...
  77. ncbi Validation of a modified Early Warning Score in medical admissions
    C P Subbe
    Department of Medicine, Wrexham Maelor Hospital, Wrexham, UK
    QJM 94:521-6. 2001
    ..A clinical pathway could be created, using nurse practitioners and/or critical care physicians, to respond to high scores and intervene with appropriate changes in clinical management...
  78. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  79. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
    ..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment.
  80. pmc Low diagnostic yield of elective coronary angiography
    Manesh R Patel
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    N Engl J Med 362:886-95. 2010
    Guidelines for triaging patients for cardiac catheterization recommend a risk assessment and noninvasive testing...
  81. ncbi European system for cardiac operative risk evaluation (EuroSCORE)
    S A Nashef
    Papworth Hospital, Cambridge, UK
    Eur J Cardiothorac Surg 16:9-13. 1999
    ..To construct a scoring system for the prediction of early mortality in cardiac surgical patients in Europe on the basis of objective risk factors...
  82. pmc Interactions between chemical and climate stressors: a role for mechanistic toxicology in assessing climate change risks
    Michael J Hooper
    U S Geological Survey, Columbia Environmental Research Center, Columbia, MO, USA
    Environ Toxicol Chem 32:32-48. 2013
    ....
  83. pmc Sedentary behaviors increase risk of cardiovascular disease mortality in men
    Tatiana Y Warren
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Med Sci Sports Exerc 42:879-85. 2010
    ..The purpose of this study was to examine the relationship between two sedentary behaviors (riding in a car and watching TV) and cardiovascular disease (CVD) mortality in men in the Aerobics Center Longitudinal Study...
  84. doi Public health importance of triggers of myocardial infarction: a comparative risk assessment
    Tim S Nawrot
    Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
    Lancet 377:732-40. 2011
    ..However, the importance and relevance of each trigger are uncertain. We compared triggers of myocardial infarction at an individual and population level...
  85. ncbi Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 16:393-401. 2007
    ..We sought to replicate in THIN well-established associations from the medical literature and to compare results from the GPRD practices to the non-GPRD practices within THIN...
  86. ncbi Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research and the Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 297:611-9. 2007
    ..Despite improved understanding of atherothrombosis, cardiovascular prediction algorithms for women have largely relied on traditional risk factors...
  87. ncbi Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, England
    Arch Intern Med 165:2644-50. 2005
    ..We sought to compare metabolic syndrome (MetS) with the Framingham Risk Score (FRS) as predictors of coronary heart disease (CHD), stroke, and type 2 diabetes mellitus (DM2) in middle-aged men...
  88. ncbi Risk assessment for vitamin D
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC 20036 5114, USA
    Am J Clin Nutr 85:6-18. 2007
    The objective of this review was to apply the risk assessment methodology used by the Food and Nutrition Board (FNB) to derive a revised safe Tolerable Upper Intake Level (UL) for vitamin D...
  89. ncbi Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  90. ncbi 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
    George Davey Smith
    University of Bristol, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Int J Epidemiol 32:1-22. 2003
    ....
  91. ncbi Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
    Rod Jackson
    Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Lancet 365:434-41. 2005
    ..An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors...
  92. pmc From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes
    Zhi Wei
    Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
    PLoS Genet 5:e1000678. 2009
    ..machine-learning approaches with a large ensemble of markers may improve the performance of disease risk assessment. We applied a Support Vector Machine (SVM) algorithm on a GWAS dataset generated on the Affymetrix genotyping ..
  93. pmc The risks of malaria infection in Kenya in 2009
    Abdisalan M Noor
    Centre for Geographic Medicine, KEMRI University of Oxford, Kenyatta National Hospital Grounds, Nairobi, Kenya
    BMC Infect Dis 9:180. 2009
    ..Here we present a new map of malaria risk for Kenya in 2009...
  94. doi Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, Zaragoza, Spain
    Am J Gastroenterol 104:1633-41. 2009
    ....
  95. doi Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004
    Heli Ghandehari
    Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, CA 92697, USA
    Am Heart J 156:112-9. 2008
    ..We evaluated the proportion of US adults with and without these conditions at (and distance to) recommended levels of LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), HDL-C, and triglycerides...
  96. pmc Glycated hemoglobin and associated risk factors in older adults
    Raul A Martins
    Faculty of Sport Sciences and Physical Education, University of Coimbra, Estádio Universitário, Pavilhão 3, 3040 156 Coimbra, Portugal
    Cardiovasc Diabetol 11:13. 2012
    ..Age is associated with several risk factors as increased body fat and abdominal fat, deterioration of the lipid profile, diabetes, raising in inflammatory activity, or decreased functional fitness...
  97. doi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
  98. ncbi International variations in hip fracture probabilities: implications for risk assessment
    John A Kanis
    WHO Collaborating Center for Metabolic Bone Diseases, University of Sheffield Medical School, United Kingdom
    J Bone Miner Res 17:1237-44. 2002
    ..The categorization of hip fracture probabilities can be used to adjust intervention thresholds based on age, sex, and relative risk from a reference population such as Sweden...
  99. ncbi Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States
    Paul Muntner
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
    J Am Soc Nephrol 13:745-53. 2002
    ..This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates...
  100. pmc Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment
    Yan Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Environ Health Perspect 118:818-24. 2010
    ..Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a known human liver carcinogen...
  101. pmc A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
    Samuli Ripatti
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland mm fi
    Lancet 376:1393-400. 2010
    ..We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design...

Research Grants75

  1. Infant Screening and Diagnosis of Duchenne Muscular Dys*
    Paul Fernhoff; Fiscal Year: 2007
    ..These data points will be tracked throughout the project. ..
  2. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..We will then estimate the cost-savings associated with more rational BAT use to test the hypothesis that PRISM will improve the cost-effectiveness of PCI. ..
  3. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ....
  4. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..Public Health Relevance: This research has potential to influence health policy and practices that may directly translate to improved nutritional and health outcomes for premature VLBW infants. ..
  5. The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
    Kruti Acharya; Fiscal Year: 2012
    ..The results of the proposed research will be used to develop an R01 application examining the lifetime risks and benefits of carrying a genetic diagnosis for these conditions. ..
  6. Feasibility, Efficacy, and Mechanisms of Surgical vs Medical Diabetes Treatment
    David R Flum; Fiscal Year: 2012
    ..abstract_text> ..
  7. The Physiologic Assessment of Exercise Capacity in Pediatric Sickle Cell Anemia
    ROBERT IE LIEM; Fiscal Year: 2013
    ....
  8. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2011
    ..Relevance to public health: This study will examine in HD patients the role of protein intake in malnutrition and cardiovascular disease, two of the most important problems in these patients. ..
  9. Toward personalized diabetes care: Understanding hypoglycemia in older adults
    KASIA JOANNA LIPSKA; Fiscal Year: 2013
    ..abstract_text> ..
  10. Safety and Effectiveness Evaluations for Diabetes
    DONALD READ MILLER; Fiscal Year: 2013
    ..abstract_text> ..
  11. The Comparative Effectiveness of Single versus Dual Chamber Cardioverter Defibril
    Pamela N Peterson; Fiscal Year: 2013
    ....
  12. 2012 Oceans and Human Health Gordon Research Conference and Gordon Research Semi
    Darrell Jay Grimes; Fiscal Year: 2012
    ....
  13. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2010
    ..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..
  14. HAART to Prevent HIV Transmission to Infants In Botswana
    Roger L Shapiro; Fiscal Year: 2010
    ..The Botswana government has given explicit support for this protocol to occur in four existing Botswana-Harvard AIDS Institute Partnership (BHP) locations to help guide future policy decisions. ..
  15. Comparative effectiveness of ECG screening in children with Attention Deficit Hyp
    Laurel K Leslie; Fiscal Year: 2010
    ..In this application, we propose to apply three up-to-date methodologies - evidence-based synthesis, decision analysis, and preference elicitation - to address this pressing clinical and public policy issue. ..
  16. Population-Based Assessment of Cancer Trial Generalizability in the Elderly
    Elizabeth B Lamont; Fiscal Year: 2012
    ....
  17. Diabetes and Aging in a Multi-Ethnic Population
    Andrew John Karter; Fiscal Year: 2013
    ..abstract_text> ..
  18. 2/3-Improving Metabolic Parameters of Antipsychotic Child Treatment
    Linmarie Sikich; Fiscal Year: 2012
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
  19. 1/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)
    Mark A Riddle; Fiscal Year: 2012
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
  20. 3/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)
    Christoph U Correll; Fiscal Year: 2012
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
  21. Chronic Moderate Sleep Restriction in Older Long and Older Average Sleepers
    Shawn D Youngstedt; Fiscal Year: 2013
    ..Follow-up assessments will be conducted for 12 months. The proposed clinical trial will provide the most comprehensive Phase 1 assessment of risks and benefits of chronic moderate TIB restriction ever conducted. ..
  22. Atlases to Report and Correlate Radiotherapy Dose Distributions with Outcomes
    Andrew Jackson; Fiscal Year: 2013
    ..This should permit the safe delivery of higher biologically effective doses to tumors, resulting in improved local control. ..
  23. Prolonged Clopidogrel Use After Drug-Eluting and Bare-Metal Coronary Stenting
    Scott Kinlay; Fiscal Year: 2013
    ..These data may also inform future randomized trials to address the value of prolonged clopidogrel therapy. ..
  24. Use and Outcomes of Radiation Therapy for Medicare Patients with Common Cancers
    Cary P Gross; Fiscal Year: 2012
    ....
  25. Risks of Warfarin for Elders with Atrial Fibrillation
    Margaret C Fang; Fiscal Year: 2010
    ..Together, these projects will provide practical experience and form the basis for future studies that seek to improve the safety and use of anticoagulants in the oldest patients with atrial fibrillation. ..
  26. Optimizing Patient-Oriented Outcomes for Chronic Hepatitis C
    Mai Tuyet Pho; Fiscal Year: 2013
    ..abstract_text> ..
  27. Drinking Patterns and Post MI Prognosis in Women
    Murray A Mittleman; Fiscal Year: 2010
    ..We will also evaluate current trends in drinking behavior among women in the US who have coronary heart disease or are at high risk of developing it. ..
  28. Communicating Genetic Test Results by Telephone: A Randomized Trial
    Angela R Bradbury; Fiscal Year: 2013
    ..Given the rising number of available genetic tests, this research has the potential to impact a significant and growing community of patients and their providers seeking genetic risk information to improve their health. ..
  29. The relationship between pets and multiple child health indicators
    ANNE M GADOMSKI; Fiscal Year: 2013
    ..This study will also produce an intervention prototype for primary care providers to use to guide parents in a discussion of the risks and benefits of routine dog ownership for their children. ..
  30. Pesticide Use & Breast Cancer Risk in Large Cohort of Female Agriculture Workers
    LAWRENCE STUART ENGEL; Fiscal Year: 2010
    ..The proposed study will help address these important gaps in our knowledge and help to inform the debate among policy makers and individuals concerning the risks and benefits of these chemicals. ..
  31. Endocannabinoid Signaling During Early Pregnancy
    Sudhansu K Dey; Fiscal Year: 2012
    ..abstract_text> ..
  32. Optimizing HIV Pre-Exposure Prophylaxis through Shared Decision Making
    DOUGLAS SCOTT KRAKOWER; Fiscal Year: 2013
    ..The research is significant because it is expected to fundamentally alter clinical decision making for PrEP and other biomedical prevention strategies. ..
  33. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  34. Interaction of Estrogen and Serotonin in Modulating Brain Activation in Menopause
    C Neill Epperson; Fiscal Year: 2010
    ..This application is both novel and timely as results from this study are likely to provide information critical to the on-going discussion regarding the risks and benefits of ET use in menopausal women. ..
  35. A Multicultural, Multilingual HPV Vaccine Education DVD for Diverse Populations
    Armando Valdez; Fiscal Year: 2010
    ....
  36. Methyl Mercury Effect on Adolescent Development Renewal
    Philip W Davidson; Fiscal Year: 2013
    ..The study should also clarify the risks and benefits of fish consumption in relation to neurocognitive and cardiac morbidity that may not become clinically manifest until later in adulthood. ..
  37. Parent Communication of BRCA1/2 Test Results to Children
    KENNETH TERCYAK; Fiscal Year: 2009
    ..Findings generated in this area offer a new paradigm within which to view and understand the psychosocial outcomes of predictive testing among tested parents and their nontested children. ..
  38. Developing and Validating a Veterans Affairs Cardiac Risk Score
    Rodney A Hayward; Fiscal Year: 2013
    ....
  39. Modifiable Disparities in Treatment for Rheumatoid Arthritis
    DANIEL HAL SOLOMON; Fiscal Year: 2012
    ..abstract_text> ..
  40. Cognition In Older Breast Cancer Survivors: Treatment Exposure, APOE, &Smoking
    Arti Hurria; Fiscal Year: 2013
    ....
  41. HPV Vaccine Education Intervention for Medically Underserved High-risk Population
    Armando Valdez; Fiscal Year: 2013
    ..It also leverages our extensive experience with complex, multicultural, multilingual studies to effectively manage the challenges of this multi-audience health literacy study. ..
  42. Does depression affect quality of decisions to participate in clinical trials?
    Yan Leykin; Fiscal Year: 2013
    ..Results of this investigation will provide data needed to determine the appropriate level and types of protection and safeguards for depressed individuals enrolling in research. ..
  43. Comparative Effectiveness of Localized Prostate Cancer Treatments (Pilot Study)
    Austin B Frakt; Fiscal Year: 2013
    ..Independent variables will include age, co-morbidities, county-level demographics (education, income, provider density), facility quality and VAMC fixed effects. ..
  44. Advancing HIV Research in Pregnancy;ethics and engagement
    Anne Drapkin Lyerly; Fiscal Year: 2013
    ....
  45. The effects of randomized, low-dose hormone therapy on mammographic density in KE
    Rulla M Tamimi; Fiscal Year: 2013
    ....
  46. PREDICTORS OF SPONTANEOUS CEREBRAL AVM HEMORRHAGE
    Helen Kim; Fiscal Year: 2013
    ..Taken together, there is a pressing need to improve risk assessment. Aim 1 will demonstrate that Silent Intralesional Microhemorrhage (SIM) is a novel risk factor for bAVM ..
  47. PACTTE-Partnership for Anemia: Clinical and Translational Trials in the Elderly
    Harvey Jay Cohen; Fiscal Year: 2012
    ..This Unexplained anemia in the elderly (UAA) can be clinically defined and also shows increased mortality. As the risks or benefits of treatment are completely unknown, UAE is ideally suited for interventional trials. ..
  48. Vascular Risk Factors and Dementia in the Oldest-Old
    Maria M Corrada; Fiscal Year: 2013
    ....
  49. HBV HIV Coinfection Research Network
    Richard Keith Sterling; Fiscal Year: 2013
    ..We will assess the long term renal and bone effects of TDF-based therapy in the HBV-HIV cohort. Collectively, this study will fulfill many of the key priorities outlined in the NIH Action Plan fo Liver Disease for HBV-HIV coinfection. ..
  50. Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
    DANIEL EDWIN SINGER; Fiscal Year: 2010
    ....
  51. Comparative Effectiveness of Treatment Options for Asymptomatic Carotid Disease
    Steven D Pizer; Fiscal Year: 2013
    ..Using a unique national sample of veterans and instrumental variables analysis we will examine the causal relationship between treatment approach and risk-adjusted health outcomes. ..
  52. Research Training: Complementary &Integrative Medicine
    Gloria Y Yeh; Fiscal Year: 2013
    ....
  53. Age, functional status, and survival benefit from kidney transplantation
    Peter Philip Reese; Fiscal Year: 2013
    ....
  54. Ethical issues in Dementia Research involving Surrogates and Study Partners
    BETTY E BLACK; Fiscal Year: 2013
    ....
  55. Alcohol Use and Relationship Distress in Married Couples
    Lindsey Rodriguez; Fiscal Year: 2013
    ..Finally, the award will aid in the ethical, methodological, and substantive training of a promising new researcher to address the need for important, innovative research in the domain of drinking and marriage. ..
  56. Assessing Attitudes and Experiences of Early Adopters of Personalized Genomics
    Barbara A Bernhardt; Fiscal Year: 2010
    ..to determine the clinical utility of personalized medicine by offering participants a personalized genomic risk assessment for a variety of diseases and collecting data on health outcomes...
  57. Alcohol Epidemiological Data System (AEDS)
    Hsiao ye Yi; Fiscal Year: 2011
    ..The focus of the AEDS contract is secondary data analysis of survey data and collection of secondary survey data for use in scientific reports. ..
  58. How and Where Methylphenidate Exerts Effect in Adolescent and Adult Brains
    Nachum Dafny; Fiscal Year: 2013
    ..These data are essential to understand how Ritalin affect the brain and will be beneficial to the ADHD patient and psychostimulant drug abusers in general. ..
  59. Adolescent Bariatrics: Controlled Longitudinal Study of Psychosocial Development
    MARGARET H ZELLER; Fiscal Year: 2012
    ..Hence, the innovative aims and research design of the proposed study will significantly enhance the scientific contribution of the Teen-LABS. ..
  60. Alcohol Epidemiological Data System (AEDS)
    Hsiao ye Yi; Fiscal Year: 2009
    ..The focus of the AEDS contract is secondary data analysis of survey data and collection of secondary survey data for use in scientific reports...
  61. Alcohol Epidemiological Data System (AEDS)
    Hsiao ye Yi; Fiscal Year: 2012
    ..The focus of the AEDS contract is secondary data analysis of survey data and collection of secondary survey data for use in scientific reports. ..
  62. Alcohol, Estrogen Replacement Therapy (ERT) and Cognition in Menopausal Women
    Laura Tivis; Fiscal Year: 2009
    ..Long- term benefits include an increased understanding of the associations between alcohol consumption and overall health (including cognition), and the influences of specific health-related behaviors. ..
  63. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2003
    ..BUDGET NOTE: NEI Staff should evaluate the requested budget in light of their experience with the budget needs of reading centers in other clinical trials. ADMINISTRATIVE NOTE: Awards, if made, are limited to 5 years. ..
  64. ETHICS COURSE SCIENTIST-PARTICIPANT PARTNERSHIPS
    Celia Fisher; Fiscal Year: 2000
    ....
  65. ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTION
    Annlia Paganini Hill; Fiscal Year: 1991
    ..Extension of these models for use with disease rates and exposure variables that vary continuously with age or time (the proportional hazards model of Cox) will also be used...
  66. EFFICACY AND SAFETY OF NARCOTICS FOR PEDIATRIC SEDATION
    Paul Moore; Fiscal Year: 1990
    ..The use of multiple behavioral assessment scales and multiple physiologic measures will permit a simultaneous evaluation of the sensitivity and reliability available methodologies for determining clinical safety and efficacy...
  67. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..Information from these analyses will be used in linear programming to predict how the described changes in nutrient content of milk due to heating would affect the overall dietary needs of the child and the associated costs. ..
  68. PRESCRIPTION PATTERNS & PRACT FOR POSTMEMOPAUSAL THERAPY
    JENNIFER MIGLIONICO; Fiscal Year: 2000
    ..abstract_text> ..
  69. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  70. MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITS
    Thomas Giles; Fiscal Year: 2001
    ..The exacerbation or prevention of EIH will be related to drug effects on the cell-signaling pathway. This research can define the cell-signaling pathway in EIH and provide new and novel approaches to treating EIH. ..
  71. TAMOXIFEN--RISK OF MI, STROKE AND VENOUS THROMBOEMBOLISM
    Leslie Bernstein; Fiscal Year: 2001
    ....
  72. Shared Decision-making in Surgery to Improve Patient Safety and Reduce Liability
    KAREN BARBARA DOMINO; Fiscal Year: 2010
    ..These results will be useful to health systems in making decisions regarding implementation of shared decision-making. ..
  73. Ethical Issues in Living Donor Transplantation
    Lainie Ross; Fiscal Year: 2009
    ..Part VI provides a methodological consideration of the numerous policy recommendations and revisions that are offered throughout the book to promote the ethical participation of living persons as organ sources. ..
  74. Cardiovascular Risk Factors and Lifestyle Modification in Breast Cancer Survivors
    Wendy Chen; Fiscal Year: 2009
    ....
  75. End-of-Life Research Ethics: Concerns, Approaches, and Impact
    Susan Hickman; Fiscal Year: 2009
    ....