animal care committees


Summary: Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).

Top Publications

  1. ncbi Field studies and the IACUC: protocol review, oversight, and occupational health and safety considerations
    Kathy Laber
    Medical University of South Carolina, Charleston, SC 29425, USA
    Lab Anim (NY) 36:27-33. 2007
  2. ncbi New CEO, new IACUC? A word from OLAW and USDA
    Patricia Brown
    Office of Laboratory Animal Welfare, OER, OD, NIH, HHS, USA
    Lab Anim (NY) 36:16. 2007
  3. ncbi Grants proposals and animal use protocols: is the IACUC playing by the rules? Instant replay' required
    H Edwin Kennah
    Occupational and Environmental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lab Anim (NY) 35:16-7. 2006
  4. ncbi Tackling investigator noncompliance: Stop and investigate
    Anthony McMickle
    Arkansas State University Biosciences Institute, Jonesboro, AR, USA
    Lab Anim (NY) 35:17. 2006
  5. ncbi Report knocks agriculture department's protection of research animals
    Jeffrey Brainard
    Chron High Educ 52:A27. 2005
  6. ncbi Adoption complications: USDA pain categories do not apply
    Eva B Ryden
    Research Animal Facility, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Lab Anim (NY) 34:19-20. 2005
  7. ncbi Training for best practices for agricultural programs
    Wendy J Underwood
    Eli Lily and Company, Lilly Corporate Center, 98 a1105 DC 0417, Indianapolis, IN 46285, USA
    Lab Anim (NY) 34:29-32. 2005
  8. ncbi Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinion
    Jerald Silverman
    Department of Animal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Contemp Top Lab Anim Sci 44:34-6. 2005
  9. ncbi Training the trainee: the institution's responsibility to the often forgotten
    Joseph N Benoit
    The University of North Dakota Graduate School, Grand Forks, ND 58202, USA
    Lab Anim (NY) 34:46-50. 2005
  10. ncbi Is the IACUC interfering with study design? Freedom without accountability
    James R Owiny
    Department of Comparative Medicine, Johns Hopkins University, Baltimore, MD, USA
    Lab Anim (NY) 34:18-9. 2005

Research Grants

Detail Information

Publications223 found, 100 shown here

  1. ncbi Field studies and the IACUC: protocol review, oversight, and occupational health and safety considerations
    Kathy Laber
    Medical University of South Carolina, Charleston, SC 29425, USA
    Lab Anim (NY) 36:27-33. 2007
    ..The authors explore many of these challenges, including the special protocol considerations and idiosyncratic occupational health and safety concerns characteristic of field-study reviews...
  2. ncbi New CEO, new IACUC? A word from OLAW and USDA
    Patricia Brown
    Office of Laboratory Animal Welfare, OER, OD, NIH, HHS, USA
    Lab Anim (NY) 36:16. 2007
  3. ncbi Grants proposals and animal use protocols: is the IACUC playing by the rules? Instant replay' required
    H Edwin Kennah
    Occupational and Environmental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lab Anim (NY) 35:16-7. 2006
  4. ncbi Tackling investigator noncompliance: Stop and investigate
    Anthony McMickle
    Arkansas State University Biosciences Institute, Jonesboro, AR, USA
    Lab Anim (NY) 35:17. 2006
  5. ncbi Report knocks agriculture department's protection of research animals
    Jeffrey Brainard
    Chron High Educ 52:A27. 2005
  6. ncbi Adoption complications: USDA pain categories do not apply
    Eva B Ryden
    Research Animal Facility, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Lab Anim (NY) 34:19-20. 2005
  7. ncbi Training for best practices for agricultural programs
    Wendy J Underwood
    Eli Lily and Company, Lilly Corporate Center, 98 a1105 DC 0417, Indianapolis, IN 46285, USA
    Lab Anim (NY) 34:29-32. 2005
    ..The author provides guidance for the development of appropriate training programs for organizations that use agricultural animals in research...
  8. ncbi Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinion
    Jerald Silverman
    Department of Animal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Contemp Top Lab Anim Sci 44:34-6. 2005
    ..We present a rationale for including decerebrate animals in USDA category D. We also provide a general review of decerebration and suggestions for institutional animal care and use committees having to evaluate decerebration protocols...
  9. ncbi Training the trainee: the institution's responsibility to the often forgotten
    Joseph N Benoit
    The University of North Dakota Graduate School, Grand Forks, ND 58202, USA
    Lab Anim (NY) 34:46-50. 2005
    ..The authors draw attention to a common problem facing universities and suggest ways to close the gap in training...
  10. ncbi Is the IACUC interfering with study design? Freedom without accountability
    James R Owiny
    Department of Comparative Medicine, Johns Hopkins University, Baltimore, MD, USA
    Lab Anim (NY) 34:18-9. 2005
  11. ncbi When the IACUC and AV don't agree, who wins?: Listen to the AV
    Karen Cadle
    Bioanalytical Systems Inc, West Lafayette, IN, USA
    Lab Anim (NY) 34:24. 2005
  12. ncbi When the IACUC and AV don't agree, who wins?: Make the AV part of the plan
    Tonja M Henze
    Laboratory Animal Facilities, University of Illinois, Urbana, IL, USA
    Lab Anim (NY) 34:24. 2005
  13. ncbi When the IACUC and AV don't agree, who wins?: Veterinary variability
    Todd A Jackson
    Bristol Myers Squibb s Pharmaceutical Research Institute, Evansville, IN, USA
    Lab Anim (NY) 34:23-4. 2005
  14. ncbi Enrichment and nonhuman primates: "first, do no harm"
    Randall J Nelson
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    ILAR J 46:171-7. 2005
    ..These discussions follow the central premise that enrichment should benefit all involved and "First, do no harm."..
  15. ncbi The role of a clinical veterinarian in a safety assessment testing facility
    Denise Fillman-Holliday
    Department of Laboratory Animal Science at GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA 19406, USA
    Lab Anim (NY) 34:35-8. 2005
  16. ncbi Electronic (mis)communication in IACUC procedures. A word from OLAW and USDA
    Carol Wigglesworth
    Office of Laboratory Animal Welfare, OER, OD, National Institutes of Health, HHS, Bethesda, MD 20892, USA
    Lab Anim (NY) 34:19. 2005
  17. ncbi Protocol audits for post-approval monitoring of animal use protocols
    Jamie F Smelser
    Animal Welfare Program, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, USA
    Lab Anim (NY) 34:23-7. 2005
    ..This program, as well as the protocol audit form they provide, can be used by institutions to initiate, enhance, or evaluate post-approval monitoring programs...
  18. ncbi Grants proposals and animal use protocols: is the IACUC playing by the rules? Modular doesn't apply
    Michele Cunneen
    The AWEN Group Inc, Waltham, MA, USA
    Lab Anim (NY) 35:17-8. 2006
  19. ncbi Grants proposals and animal use protocols: is the IACUC playing by the rules? Don't ignore the proposal
    Michael D Mann
    Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
    Lab Anim (NY) 35:17. 2006
  20. ncbi Grants proposals and animal use protocols: is the IACUC playing by the rules? A word from OLAW
    Carol Wigglesworth
    Office of Laboratory Animal Welfare, OER, OD, NIH, HHS
    Lab Anim (NY) 35:18. 2006
  21. ncbi Training strategies for IACUC members and the institutional official
    M E Greene
    Michigan State University, IACUC Office A620 E Fee Hall, East Lansing, MI 48824, USA
    ILAR J 48:131-42. 2007
    ..For both the IO and the IACUC, understanding and acceptance of their authority and responsibilities are significant factors in establishing and maintaining a quality animal care and use program...
  22. ncbi Establishing a culture of care, conscience, and responsibility: addressing the improvement of scientific discovery and animal welfare through science-based performance standards
    H J Klein
    Department of Laboratory Animal Resources, Merck Research Laboratories, Rahway, NJ, USA
    ILAR J 48:3-11. 2007
  23. ncbi Tackling investigator noncompliance: a word from OLAW and USDA
    Patricia Brown
    Lab Anim (NY) 35:18. 2006
  24. ncbi Tackling investigator noncompliance: Decide now
    Todd A Jackson
    Veterinary Sciences, Bristol Myers Squibb, Pharmaceutical Research Institute, Evansville, IN, USA
    Lab Anim (NY) 35:16. 2006
  25. ncbi Tackling investigator noncompliance: Cooperation counts
    Marc Breedlove
    Michigan State University, East Lansing, MI, USA
    Lab Anim (NY) 35:16-7. 2006
  26. ncbi Preparation of animals for use in the laboratory: issues and challenges for the Institutional Animal Care and Use Committee (IACUC)
    Steven A Schapiro
    Department of Comparative Medicine, Michale E Keeling Center for Comparative Medicine and Research of The University of Texas M D Anderson Cancer Center, Bastrop, TX, USA
    ILAR J 47:370-5. 2006
    ..As empirical data are produced that affect additional aspects of animal care and use, it is important for these committees to be able to evaluate and, when appropriate, stimulate the implementation of improved procedures and strategies...
  27. ncbi Report of the Working Group on Animal Distress in the Laboratory
    Marilyn Brown
    Charles River Laboratories Foundation, 251 Ballardvale Street, Wilmington, MA 01887, USA
    Lab Anim (NY) 35:26-30. 2006
  28. ncbi Making sense of multiple protocols and grant applications. Room for improvement
    Lara A Weaver
    Division of Teaching and Research Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA
    Lab Anim (NY) 35:16-7. 2006
  29. ncbi Making sense of multiple protocols and grant applications. Failure of compliance by confusion?
    Valerie Parkison
    Tufts NEMC, Boston, MA, USA
    Lab Anim (NY) 35:15-6. 2006
  30. doi Collaborative studies and animal reuse: one study, two institutions
    Betsy L Bashaw
    Animal Resources Facility, Albany Medical College, Albany, NY, USA
    Lab Anim (NY) 37:61-2. 2008
  31. doi Collaborative studies and animal reuse: a word from OLAW and USDA
    Patricia Brown
    Lab Anim (NY) 37:63. 2008
  32. ncbi Management of unanticipated outcomes in transgenic mouse facilities
    Stacy Pritt
    Covance Research Products, Inc, Denver, PA 17517, USA
    Lab Anim (NY) 35:27-30. 2006
  33. ncbi Conference wet lab: is an IACUC needed? Response to protocol review scenario: convene a committee
    Tamara Goodman-Kuhel
    University of Cincinnati, OH, USA
    Lab Anim (NY) 35:16. 2006
  34. ncbi Conference wet lab: is an IACUC needed? Response to protocol review scenario: satellite situation
    Amy J Funk
    St Jude Children s Research Hospital, Memphis, TN, USA
    Lab Anim (NY) 35:16-7. 2006
  35. ncbi Whistleblower woes: focus on the issue
    Michele Courtney
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA, USA
    Lab Anim (NY) 35:16. 2006
  36. ncbi Minimizing harm in agricultural animal experiments in New Zealand
    M C Morris
    Environmental Studies, School of Earth Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    J Agric Environ Ethics 16:421-37. 2003
    ..Many of these experiments had questionable short-term applications, had an application restricted to agricultural production or economic growth, or could have been modified to prevent or reduce suffering...
  37. ncbi Dealing with IACUC dysfunction
    James G Christenson
    Lab Anim (NY) 33:13. 2004
  38. ncbi Clinical blood draws: when do they require IACUC approval?
    Stacy Pritt
    Animal Resources Facility, Joslin Diabetes Center, Boston, MA, USA
    Lab Anim (NY) 33:17-21. 2004
  39. ncbi Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations
    Penny Hawkins
    Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK
    Lab Anim 36:378-95. 2002 2002). The present paper and the full report, including its recommendations, are intended to provide a source of information, discussion topics and ideas for all establishments that need to monitor animal well-being...
  40. ncbi Reporting noncompliance in the animal facility
    Vicki Koch
    Lab Anim (NY) 32:27. 2003
  41. ncbi A tool for semiannual review of the institutional animal care and use program
    Holly I McEntee
    Research Animal Resources Center, University of Wisconsin Madison, 1710 University Avenue, Madison, WI 53726, USA
    Lab Anim (NY) 36:36-40. 2007
    ..The authors present a worksheet that they developed and successfully implemented at their institution, aimed at inspiring an efficient and fruitful discussion of animal care and use...
  42. ncbi Programs for invasive research in North American zoos and aquariums
    Karen L Goodrowe
    Point Defiance Zoo and Aquarium, Tacoma, WA, USA
    ILAR J 44:317-23. 2003
    ..A more standardized approach among zoological institutions for examining and approving research projects that are supported by zoo-based conservation programs would greatly facilitate the wildlife research efforts of North American zoos...
  43. ncbi The refining influence of ethics committees on animal experimentation in Sweden
    Joakim Hagelin
    Department of Physiology, Division of Comparative Medicine, Uppsala University, Box 572, SE 751 23 Uppsala, Sweden
    Lab Anim 37:10-8. 2003
    ..In order to have maximal influence on the refinement of scientific protocols it is important that the scientists in the committees are continuously updated on developments in laboratory animal science...
  44. ncbi Knowledge about animal suffering is too rarely used
    Andrew N Rowan
    Nature 417:587. 2002
  45. ncbi Best practices for animal care committees and animal use oversight
    W Ron DeHaven
    Animal Care Division, US Department of Agriculture s Animal Plant Health Inspection Service, USA
    ILAR J 43:S59-62. 2002
    ..These animal care committees (ACCs) are part of an institutional animal welfare team that includes the institutional administration, ..
  46. ncbi Should IACUCs review scientific merit of animal research projects?
    Michael D Mann
    IACUC, Nebraska Medical Center, Omaha, 68198 7830, USA
    Lab Anim (NY) 33:26-31. 2004
    ..The authors examine this issue, discuss the pros and cons, suggest how IACUCs can go about reviewing protocols for scientific merit, and question what effect recent changes in regulations will have on this issue...
  47. ncbi Retiring to a chimp paradise
    Bridget M Kuehn
    J Am Vet Med Assoc 222:565-6. 2003
  48. ncbi Opportunistic research and sampling combined with fisheries and wildlife management actions or crisis response
    David A Jessup
    California Department of Fish and Game, Santa Cruz, CA, USA
    ILAR J 44:277-85. 2003
    ..Several unique limitations of sample collection situation are described. It is recommended that IACUCs have mechanisms in place to facilitate good research in all of these circumstances...
  49. ncbi Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model
    Mahmoud A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
    Mycoses 52:35-43. 2009
    ..Evaluation of the 1%, 5% and 10% TNS in clinical trials for the treatment of dermatophytosis and onychomycosis is warranted...
  50. ncbi Public attitudes in New Zealand towards the use of animals for research, testing and teaching purposes
    V M Williams
    Animal Welfare Group, Biosecurity New Zealand, PO Box 2526, Wellington, New Zealand
    N Z Vet J 55:61-8. 2007
  51. pmc Factors influencing the effectiveness of research ethics committees
    C A Schuppli
    Animal Welfare Program, University of British Columbia, 2357 Main Hall, Vancouver, British Columbia, V6T 1Z4, Canada
    J Med Ethics 33:294-301. 2007
    ..These results, together with results from the literature on research ethics committees, suggested potential ways to improve the effectiveness of research ethics committees...
  52. ncbi Comparative studies on the topical administration of mucopolysaccharide and heparin ointments in nonhuman primates
    Debra A Hoppensteadt
    Department of Pathology, Loyola University Chicago, Chicago, Illinois, USA
    Clin Appl Thromb Hemost 16:13-20. 2010
    ..In conclusion, MPS showed a stronger release of TFPI than heparin that was not associated with a strong anticoagulant effect. Moreover, MPS downregulated TAFI, resulting in an enhanced fibrinolytic effect...
  53. pmc Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model
    Wei Yang
    Minimally Invasive Tumor Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Hyperthermia 27:527-38. 2011
    ..To investigate the effect of heat shock protein (HSP) modulation on tumour coagulation by combining radiofrequency (RF) ablation with adjuvant liposomal quercetin and/or doxorubicin in a rat tumour model...
  54. pmc Impact of supra-physiologic retinoids on ovalbumin-sensitized f344 lung tissue and reversal of related pathology by citral - biomed 2011
    Ibrahim O Farah
    University of Mississippi Medical Center, Jackson, Mississippi
    Biomed Sci Instrum 47:195-200. 2011
    ..These findings warrants further investigation as to the actual role of these interactions in relation to chronic lung disease and the possibility of reversing retinoid-mediated pathologies in the Fisher rat model...
  55. ncbi Real-time quantitation of renal ischemia using targeted microbubbles: in-vivo measurement of P-selectin expression
    Sero Andonian
    Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    J Endourol 23:373-8. 2009
    ..The goal of this project was to use targeted microbubbles outfitted with anti-P-selectin antibodies to quantitate for the first time the microvascular reperfusion injury and regional blood flow in the kidney during IRI...
  56. ncbi Different views on ethics: how animal ethics is situated in a committee culture
    M Ideland
    Malmo University, Sweden
    J Med Ethics 35:258-61. 2009
    ..But committee traditions and priorities of interpretation as well are important to the decisions. The author discusses how "ethics" becomes situated and what implications this may have for committees' decisions...
  57. ncbi Pilot studies of pressure-immobilization bandages for rattlesnake envenomations
    William Joel Meggs
    Department of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Clin Toxicol (Phila) 48:61-3. 2010
    ..Pilot studies were performed to determine the time of onset of toxicity and efficacy of pressure-immobilizations bandages in a porcine model of rattlesnake envenomation...
  58. ncbi Probiotic acidified formula in an animal model reduces pulmonary and gastric bacterial load
    Cristiano Boneti
    Division of Pediatric Surgery, Department of Surgery, Arkansas Children Hospital, Little Rock, AR 72202, USA
    J Pediatr Surg 44:530-3. 2009
  59. pmc NOTES: issues and technical details with introduction of NOTES into a small general surgery residency program
    Michael S Kavic
    St Elizabeth Health Center, NEOUCOM for HMHP, Department of Surgery, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44501 1790, USA
    JSLS 12:37-45. 2008
    ..The Institutional Animal Care and Use Committee (IACUC) of Northeastern Ohio Universities College of Medicine and Pharmacy (NEOUCOM/COP) approved this study...
  60. ncbi Effects of interleukin-6 ablation on fracture healing in mice
    Aaron Wallace
    Penn State Hershey Medical Center, Hershey, Pennsylvania, USA
    J Orthop Res 29:1437-42. 2011
    ..110). The absence of IL-6 during early fracture healing significantly reduced osteoclastogenesis and impaired callus strength. By 6 weeks, most histological and biomechanical parameters were similar to fractures in wild-type bone...
  61. ncbi 108 a critical-size craniofacial bone defect model in the yorkshire pig
    A J Maki
    University of Illinois, Urbana
    Reprod Fertil Dev 23:159. 2011
    ..This porcine model will allow for the rapid development and testing of new approaches for the repair of damaged bone, which is especially prevalent in the craniofacial area...
  62. ncbi Survey of environmental enhancement programs for laboratory primates
    Kate C Baker
    Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Am J Primatol 69:377-94. 2007
    ..The data from this survey may be useful for anticipating future program evaluations, establishing more effective internal evaluations, and assessing program progress and resource allocation...
  63. ncbi Expanding the three Rs to meet new challenges in humane animal experimentation
    Catherine A Schuppli
    Animal Welfare Program, Faculty of Agricultural Sciences and W Maurice Young Centre for Applied Ethics, University of British Columbia, 227 6356 Agriculture Road, Vancouver, BC V6T 1Z2, Canada
    Altern Lab Anim 32:525-32. 2004
    ..The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research...
  64. ncbi Neuromuscular effects of stun device discharges
    Daniel J Valentino
    Cook Country Trauma Unit, Chicago, Illinois, USA
    J Surg Res 143:78-87. 2007
    ..To examine this type of electrical injury, we hypothesized that EMI discharges will induce acute or delayed cardiac arrhythmia and neuromuscular injury in an animal model...
  65. pmc Data and animal management software for large-scale phenotype screening
    Keith A Ching
    Genomics Institute, Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Mamm Genome 17:288-97. 2006
    ..MouseTRACS is available under an open source license at
  66. ncbi Introducing ethical evaluation of the use of animals in experiments in the Near East
    Serdar Izmirli
    Department of History of Veterinary Medicine and Deontology, Selcuk University, Konya, Turkey
    Altern Lab Anim 38:331-6. 2010
    ..The recent establishment of animal ethical review in the Near East could benefit from experiences in Western countries, in their evolution toward high standards of experimental animal ethics...
  67. ncbi Hindlimb unloading rodent model: technical aspects
    Emily R Morey-Holton
    Life Sciences Division, NASA Ames Research Center, Moffett Field, California 94035 1000, USA
    J Appl Physiol (1985) 92:1367-77. 2002
    ..Over 800 references, related to the hindlimb unloading model, can be accessed via the electronic version of this article...
  68. ncbi Immunologic parameters during NOTES compared with laparoscopy in a randomized blinded porcine trial
    Juliane Bingener
    Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Surg Endosc 23:178-81. 2009
    ..We hypothesized that there would be no difference between cytokine levels during NOTES or laparoscopic peritoneoscopy...
  69. ncbi Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healing
    Theresa A Freeman
    Department of Orthopedic Surgery, Thomas Jefferson University, Curtis Building, Suite 501, 1015 Walnut Street, Philadelphia, Pennsylvania 19107 5099, USA
    J Orthop Res 27:673-9. 2009
    ..Results of the study indicate that at sites of bone turnover, this multithresholding analytical technique can be used to provide quantitative information on bone formation, as well as resorption...
  70. ncbi Laboratory guidelines for animal care
    Marcelo Couto
    UCLA School of Medicine DLAM, Los Angeles, CA, USA
    Methods Mol Biol 770:579-99. 2011
    ..Guidance is provided regarding the appropriate handling of regulatory noncompliances...
  71. ncbi Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury
    Robert H Garman
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 28:947-59. 2011
    ..Strikingly, silver staining revealed otherwise undetected abnormalities, and therefore represents a recommended outcome measure in future studies of blast TBI...
  72. ncbi Taser X26 discharges in swine: ventricular rhythm capture is dependent on discharge vector
    Daniel J Valentino
    Cook County Trauma Unit, John Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    J Trauma 65:1478-85; discussion 1485-7. 2008
    ..We hypothesized that most transcardiac discharge vectors would capture ventricular rhythm, but that other vectors, not traversing the heart, would fail to capture the ventricular rhythm...
  73. ncbi Effect of cage enrichment on the daily use of running wheels by Syrian hamsters
    Stéphan G Reebs
    Departement de Biologie, Universite de Moncton, Moncton, NB, Canada
    Chronobiol Int 20:9-20. 2003
    Institutional animal care committees may one day require for the welfare of captive hamsters more floor space and the introduction of tunnels and toys...
  74. ncbi [Global harmonization in the care and use of laboratory animals for the space life science research]
    K Katahira
    Experimental Animal Center, Fukushima Medical University, Fukushima, Japan
    Biol Sci Space 15:30-4. 2001
    ..Even if researchers have protocols of the space science in Japan, the animal experiment should be carried out under the global harmonized conditions in accordance with NIH policies and NASA guides...
  75. ncbi Management of rodent viral disease outbreaks: one institutions (r)evolution
    Abigail L Smith
    Department of Pathobiology, University Laboratory Animal Resources, University of Pennsylvania, 3800 Spruce Street, Suite 177E OVQ, Philadelphia, PA 19104, USA
    ILAR J 51:127-37. 2010
    ..This evolution required not only support from the highest levels of leadership in the university and its school of medicine but also a huge outlay of financial resources...
  76. pmc Determination of sample sizes for demonstrating efficacy of radiation countermeasures
    Ralph L Kodell
    Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biometrics 66:239-48. 2010
  77. ncbi Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research: report of a Working Group of the NC3Rs
    Mark J Prescott
    National Centre for the Replacement, Refinement and Reduction of Animals in Research NC3Rs, 20 Park Crescent, London, UK
    J Neurosci Methods 193:167-88. 2010
    ..The report provides a framework for refinement that can be tailored to meet local requirements. It also identifies data gaps and areas for future research and sets out the Working Group's recommendations on contemporary best practice...
  78. ncbi Establishing procedures for institutional oversight of stem cell research
    Patricia Zettler
    Stanford Law School, Stanford, CA, USA
    Acad Med 82:6-10. 2007
    ..The SCRO neither replaces nor duplicates review by the IRB and institutional animal care and use committees. Other AHCs can draw on the UCSF experience when developing their own policies and procedures for stem cell research oversight...
  79. ncbi The survival and function of baboon red blood cells, platelets, and plasma proteins: a review of the experience from 1972 to 2002 at the Naval Blood Research Laboratory, Boston, Massachusetts
    C Robert Valeri
    Naval Blood Research Laboratory, Boston, Massachusetts 02360, USA
    Transfusion 46:1S-42S. 2006
  80. ncbi Invertebrate models for biomedical research, testing, and education
    Susan E Wilson-Sanders
    University Animal Care, University of Arizona, Tucson, AZ 85724 5092, USA
    ILAR J 52:126-52. 2011
    ..The models reviewed can serve as references for scientists, researchers, veterinarians, institutional animal care and use committees (IACUCs), and others interested in alternatives to vertebrate animals...
  81. ncbi Metastatic human colonic carcinoma: molecular imaging with pretargeted SPECT and PET in a mouse model
    Robert M Sharkey
    Center for Molecular Medicine and Immunology, Garden State Cancer Center, 520 Belleville Ave, Belleville, NJ 07109, USA
    Radiology 246:497-507. 2008
    ..To prospectively determine if a bispecific monoclonal antibody (MoAb) pretargeting method with a radiolabeled hapten peptide can depict small (<0.3 mm in diameter) microdisseminated human colon cancer colonies in the lungs of nude mice...
  82. ncbi A renewed look at laboratory rodent housing and management
    Janet C Gonder
    Garber Consulting LLC, Pinehurst, NC, USA
    ILAR J 48:29-36. 2007
    ..This new information is provided to aid IACUCs and facility managers in making decisions regarding the housing and care of laboratory rodents...
  83. ncbi IACUC Challenges in Invertebrate Research
    Chris Harvey-Clark
    Animal Care Centre, University of British Columbia, Vancouver, Canada
    ILAR J 52:213-20. 2011
  84. ncbi Inhibition of C5 or absence of C6 protects from sepsis mortality
    Jon A Buras
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Immunobiology 209:629-35. 2004
    ..Inhibition of the complement MAC does not increase bacterial load or mortality, therefore, the use of anti-C5 therapy may be beneficial rather than detrimental in sepsis...
  85. ncbi Computed tomographic validation of the porcine model for thoracic scoliosis
    Ashish Patel
    Department of Orthopaedics, NYU Hospital for Joint Diseases, New York, NY 10010, USA
    Spine (Phila Pa 1976) 35:18-25. 2010
    ..Computed Tomographic Analysis of the Porcine Scoliosis Model...
  86. ncbi Degenerative changes following spinal fixation in a small animal model
    Gregory D Cramer
    Department of Research, National University of Health Sciences, 200 E Roosevelt Road, Lombard, IL 60148, USA
    J Manipulative Physiol Ther 27:141-54. 2004
    ..The objective of this study was to evaluate changes of the lumbar vertebral column following fixation...
  87. ncbi Novel endoscopic application of a new flexible-fiber CO2 laser for esophageal mucosal ablation in a porcine model
    S Anandasabapathy
    Division of Gastroenterology, M D Anderson Cancer Center, Houston, Texas, USA
    Endoscopy 41:138-42. 2009
    ..The aim of the current study was to evaluate the performance, efficacy, and safety of a novel, photonic band-gap CO (2) laser configured for esophageal mucosal ablation...
  88. ncbi Apoptotic cells, autoantibodies, and the role of HMGB1 in the subcellular localization of an autoantigen
    Amy N Sanford
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Autoimmun 25:264-71. 2005
    ..This is the first description of an inflammatory stimulus altering the immunologic availability of a potential autoantigen...
  89. ncbi Multimedia article: Transvaginal laparoscopic cholecystectomy: laparoscopically assisted
    Marc Bessler
    Department of Surgery, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, Suite 620, New York, NY 10032, USA
    Surg Endosc 22:1715-6. 2008
    ..Total operative time ranged between 110 and 155 min. Based on our experience in the porcine model, we believe that a transvaginal endoscopic cholecystectomy is feasible in humans...
  90. pmc A comprehensive laboratory animal facility pandemic response plan
    Gordon S Roble
    Tri Institutional Training Program in Laboratory Animal Medicine and Science, New York, New York, USA
    J Am Assoc Lab Anim Sci 49:623-32. 2010
    ..Elements of this plan were put into practice after escalation of the pandemic alerts due to influenza A (H1N1) in April 2009...
  91. ncbi Assessing the search for and implementation of the Three Rs: a survey among scientists
    Marlies Leenaars
    Radboud University Nijmegen Medical Centre, Central Animal Laboratory, Nijmegen, The Netherlands
    Altern Lab Anim 37:297-303. 2009
  92. ncbi Effects of hydroxyapatite on titanium foam as a bone ingrowth surface in acetabular shells: a canine study
    William M Mihalko
    University of Tennessee, InMotion Orthopaedic Research Center, Campbell Clinic Orthopaedics, Memphis, TN 38017, USA
    J Long Term Eff Med Implants 20:35-42. 2010
    ..The results prove not only that titanium foam is a viable ingrowth surface but also that PA coating can enhance the time to bony incorporation...
  93. ncbi The AALAS Learning Library and its effectiveness as a tool for technician training
    Jan Parker-Thornburg
    M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Houston, TX, USA
    Lab Anim (NY) 38:195-201. 2009
    ..They also correlated ALL usage with pass rates in technician certification exams. Results suggest that the ALL is a highly effective method of training, particularly for technician certification...
  94. ncbi A guide to defining and implementing protocols for the welfare assessment of laboratory animals: eleventh report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement
    P Hawkins
    Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex RH13 9RS, UK
    Lab Anim 45:1-13. 2011
    ..A longer version of this document, with further background information and extra topics including training and information sharing, is available on the Laboratory Animals website...
  95. ncbi A new high frequency microultrasound system with applications in cardiovascular research
    F Stuart Foster
    Sunnybrook Health Sci Ctr, Univ of Toronto, 2075 Bayview Ave, and VisualSonics Inc, 3080 Yonge St, Toronto, Canada
    J Acoust Soc Am 125:2712. 2009
    ..All experiments with animals were done under a protocol approved by the Sunnybrook or VisualSonics Animal Care Committees. [The author declares a significant financial interest in VisualSonics Inc.].
  96. pmc Animal models of substance abuse and addiction: implications for science, animal welfare, and society
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
    Comp Med 60:177-88. 2010
  97. ncbi A porcine model for progressive thoracic scoliosis
    Frank Schwab
    New York University Hospital for Joint Diseases, New York, NY, USA
    Spine (Phila Pa 1976) 34:E397-404. 2009
    ..An IACUC-approved study to create a scoliotic deformity representative of adolescent idiopathic scoliosis...
  98. ncbi [Animal experiment ethics committee of Showa University]
    Norimitsu Kurata
    Nihon Yakurigaku Zasshi 129:24-30. 2007
  99. ncbi Postop monitoring: on the record? Compromise is in order
    David M Kurtz
    Experimental Pathology Laboratories, Inc, US Environmental Protection Agency, Research Triangle Park, NC, USA
    Lab Anim (NY) 34:15-6. 2005
  100. doi Response to protocol review scenario: SOPs for hypothermia
    Ann Marie Dinkel
    Delaware Technical and Community College, Georgetown, DE, USA
    Lab Anim (NY) 37:106. 2008
  101. ncbi Questioning IACUC composition: is SOCRATES' reasoning correct? Every IACUC can improve
    Lida Anestidou
    Center for Clinical and Research Ethics, Vanderbilt University Medical Center, Nashville, TN, USA
    Lab Anim (NY) 34:19-20. 2005

Research Grants62

  1. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
  2. Improving Air Quality for Laboratory Animal Research
    Sharron S Quisenberry; Fiscal Year: 2010
    ..A Project Liaison Officer will assist with communications and coordination among the key scientists and other Key Personnel. ..
  3. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Project Description Page 6 ..
  4. Restoration of Fecal Continence in Aging IAS
    Khalil N Bitar; Fiscal Year: 2012
    ..Project Description Page 6 ..
  5. Transcriptional Regulation of Retinal Development
    Mengqing Xiang; Fiscal Year: 2012
    ..The proposed studies together are expected to provide important insights into the genetic regulatory networks involved in retinal cell diversification and differentiation. Project Description Page 6 ..
  6. Renovations of the Animal Care Facility
    AWADH AMIR BINHAZIM; Fiscal Year: 2010
    ..This 32% increase in the number of research protocols in the ACF taxes the limited resources of the ACF, and the improvements described in this application are designed to accommodate the needs of Meharry investigators more fully. ..
  7. Anesthesiology &Perioperative Medicine Research Training
    Tonya M Palermo; Fiscal Year: 2013
    ..With the aging population, developing physician scientists capable of tackling scientific questions in this important arena of medicine should make care of surgery, trauma, and intensive care patients safer...
  8. Caliper Life Sciences IVIS Lumina II imaging system
    Brad T Cookson; Fiscal Year: 2012
    ..Thus, important diagnostic and potentially therapeutic information about important problems such as cancer, infection and autoimmune diseases will be provided from the studies in this application. ..
  9. Jefferson Alumni Hall Modernization of Cage Sanitation Facility
    Judith S Daviau; Fiscal Year: 2013
    ..The procurement and installation of this equipment will result in increased personnel efficiency, less down time, significant operational savings and decreased negative environmental impact. ..
  10. Remediation of Word Processing and Short-Term Memory Deficits in Aphasia
    Nadine Martin; Fiscal Year: 2009
    ..The efficacy of the treatment will be examined with probes of acquisition and maintenance in a multiple baseline across multiple stimuli design, and with comparisons of pre- and post-test ..
  11. Translational Research and Laboratory Animal Medicine Education for Veterinarians
    Diane J Gaertner; Fiscal Year: 2013
  12. Cagewash Renovation for Safety &Long-Term Research Support at The Salk Institute
    JON DAVID REUTER; Fiscal Year: 2013
    ..Funds will allow us to reallocate recharge resources to continue refurbishing older units and maintain IACUC compliance and AAALAC accreditation standards. ..
    Nancy K Mello; Fiscal Year: 2011
    Michael W Mulholland; Fiscal Year: 2013
    ..It houses on average 10,000 mice, 400 hamsters, and 8 rabbits. The facility is inspected annually by USDA, and bi-annually by UCSF/IACUC. ..
  15. Urethral Catheter to Measure Distributed Occlusive Pressures and Sphincter EMG
    Rajesh Rajamani; Fiscal Year: 2013
    ..The research team for the project includes engineering experts in sensor design and fabrication, surgeons in urology and a professor in urology who has co-founded leading urologic device companies. ..
    Patrick M Gaffney; Fiscal Year: 2011
    ..abstract_text> ..
  17. Treating EAE disease with Fc-Dimers
    David M Mosser; Fiscal Year: 2013
    ..The goal of these studies is to demonstrate (for the first time) that a therapeutic directed at reprogramming macrophages has the potential to treat autoimmune diseases. ..
  18. Development of Bimanual Coordination of Early Childhood
    KAREN E BRAKKE; Fiscal Year: 2010
    ..Additionally, it will provide research-training opportunities for several students who are under-represented minority women. Project Description Page 6 ..
  19. Movable Equipment for DDB Animal Facility
    MARVIN MICHAEL SWINDLE; Fiscal Year: 2010
    ..Maintaining an SPF environment and remaining in compliance with current and future standards of laboratory animal care and use demand the highest achievable standards of disinfection, decontamination and occupational safety. ..
  20. Animal Resource Improvement at the University of Notre Dame
    Mark A Suckow; Fiscal Year: 2012
    ..Further, the proposed upgrade will address animal health issues and optimize our ability to provide continuous monitoring of, and response for, environmental parameters key to a successful research enterprise. ..
  21. Parvin Building Animal Resources Center Improvement Plan
    Richard W Ermel; Fiscal Year: 2013
    ..5M) active and 122 ($35.3M) pending projects involving animal model research, and will help to ensure COH/BRI continues its remarkable history of innovation and achievements in science and medical care. ..
  22. Developing an Office of Sponsored Projects for Presbyterian College
    Sarah M Sweitzer; Fiscal Year: 2013
    FRANCES E SHARPLES; Fiscal Year: 2010
    ..5. To widely disseminate information on laboratory animal care and use by providing a publication at low cost to all members of the international and US biomedical communities. ..
  24. Training Clinical Veterinarians in Nonhuman Primate Clinical Medicine
    Janice D Wagner; Fiscal Year: 2010
    ..D. Anderson Cancer Research Center at Bastrop (for experience with chimpanzees and neotropical primates) are also included. ..
  25. Investigators and IACUCs: integrity in animal research
    Charles W Lidz; Fiscal Year: 2011
    ..The proposed research is a first step in a research path that can produce policy and administrative recommendations that will facilitate effective and efficient functioning of IACUCs and thus animal research. ..
    DAVID A DUBNAU; Fiscal Year: 2013
    ..b. If yes, identify countries: Germany 5.c. Optional Explanation: Collaboration with Dr. Berenike Maier 6. * Project Summary/Abstract 2297-summary.pdf Mime Type: application/pdf 7. * ..
  27. Live Cell Imaging Confocal Microscope System
    Jeffrey Shawn Goodwin; Fiscal Year: 2010
  28. Signaling in Tissue Injury and Repair
    Robert Diegelmann; Fiscal Year: 2009
    ..The Program Director has made concerted efforts and will continue to strive to attract underrepresented minorities to apply to this unique training program. ..
  29. Human Subjects Research Enhancement Program
    Stephen Slogoff; Fiscal Year: 2002
    ..Two computers, a laptop and a video camera are the only requirements for this enhancement. ..
  30. Prolonged Analgesia in Rodents
    James Johnson; Fiscal Year: 2007
    ..If this formulation is successful, it could be used for other laboratory animals with appropriate dose adjustment. [unreadable] [unreadable] [unreadable]..
  31. Primate Veterinarian Training at the WaNPRC
    Charlotte Hotchkiss; Fiscal Year: 2009
    ..abstract_text> ..
  32. A Broadly Accessible Virtual Reading Tutor
    RONALD COLE; Fiscal Year: 2009
    ..In addition, using speech recognition technology to measure the ..
  33. Development and Improvement of an Animal Resource Core
    Dale Bredesen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    TIMOTHY POOLE; Fiscal Year: 1992
    ..2. Resurfacing of Cage Wash Area Floors-Due to the heavy and harsh use of this area, the floor surface has deteriorated to such an extent that efficient cleaning and sanitation is difficult...
    Roberta Reed; Fiscal Year: 1991
    ..With the completion of the proposed alterations and renovations to the farm facility, the entire animal facility and program would be accreditable by AAALAC...
    Jack Taylor; Fiscal Year: 1991
    ..The Animal Resources program and its facilities should adequately support, now and in the future, the biomedical research of the University and its contributions to the health and well-being of mankind...
    Sandor Shapiro; Fiscal Year: 1999
    ..In addition, resources of the Cardeza Foundation library and conference room, medical illustration unit, clinical laboratory, and administrative facilities and personnel will be available for support of this training grant. ..
  38. Improving Institutional Animal Resources at MUSC
    MARVIN SWINDLE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
    Joseph Wagner; Fiscal Year: 1991
    ..Completion of this project will enable the UM to proceed with AAALAC accreditation...
  40. Fixed Equipment for DDB Animal Resource
    MARVIN SWINDLE; Fiscal Year: 2009
    ..The requested equipment will provide protection against the spread of complicating rodent diseases in the facilities. ..
    Christian Abee; Fiscal Year: 1991
    ..Completion of this phase of the university's plan will also allow us to seek university-wide AAALAC accreditation...
    JERRY STINNER; Fiscal Year: 1993
    ..Achievement of AAALAC-accreditation will be facilitated if we upgrade our new facility with the equipment requested...
  43. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
    GENE SCALARONE; Fiscal Year: 1992
    ..This proposal is for a single modern cage washing system to fully complement recent renovations and provide automated cage washing at a level of quality consistent with AAALAC standards...
    David Bernstein; Fiscal Year: 1992
    ..Alterations and renovations include electric, plumbing and exhaust...
    ALEXANDER LUCAS; Fiscal Year: 1990
    ..These modifications to the CHORI ARF will promote good animal husbandry practices and thus improve animal health and facilities management...
    Seymour Lieberman; Fiscal Year: 1990
    ..Now in it's third year, projections indicate that financial assistance from outside sources will be needed to complete planned facility renovations...
    MACK SCOTT; Fiscal Year: 1990
    ..The improvement proposed in this application will benefit all users of ACF and insure that the facility complies with federal regulations...
    MARVIN SWINDLE; Fiscal Year: 2003
    RONALD MARKLE; Fiscal Year: 1990
    ..With acquisition of the same, thorough, consistent cleaning and sterilization of animal cages and ancillary items can be met in a fashion that maximizes animal health, personnel safety and efficiency...
    William Morton; Fiscal Year: 2003
    Kristien Mortelmans; Fiscal Year: 2000
    Leland Hartwell; Fiscal Year: 2004
    Ann Henderson; Fiscal Year: 2004
    ..Further, it will allow us to maintain our outstanding record in mentoring underserved populations in science. ..
    Lee Cera; Fiscal Year: 2003
    ..It will also permit the complete initiation of barrier policies and limit mixing of clean and contaminated cages and racks. This faculty as well as members of the IACUC participated in the development of these plans. ..
    Norman Paradise; Fiscal Year: 1992
    ..The new ARC, together with the equipment requested in this proposal, will promote significant improvements in animal use and care and substantially enhance The University of Akron's biomedical research programs...
    Mark Batshaw; Fiscal Year: 2002
    ..abstract_text> ..
    CHARLES RAFLO; Fiscal Year: 1993
    ..The computer will also be used for the computerized animal accounting system (GCS) and protocol data base. These changes will significantly enhance the animal care and use program at the University of Houston...
    Louis De Tolla; Fiscal Year: 1991
    ..With NIH grant support we can rectify current inadequacies and begin to meet the needs of an increasing animal census...
    LAURETTA GERRITY; Fiscal Year: 2003
    Andrew Lackner; Fiscal Year: 2003
    ..The enhanced facility will also provide support space for the training programs for both veterinary residents in nonhuman primate medicine and in support of IACUC mandated personnel training. ..
    MALCOLM BLAIR; Fiscal Year: 2000