Genomes and Genes
formal social control
Summary: Control which is exerted by the more stable organizations of society, such as established institutions and the law. They are ordinarily embodied in definite codes, usually written.
Publications921 found, 100 shown here
- Tobacco industry direct marketing after the Master Settlement AgreementM Jane Lewis
University of Medicine and Dentistry of New Jersey, School of Public Health, New Brunswick, New Jersey, USA
Health Promot Pract 5:75S-83S. 2004..This article suggests that a first step in countering these practices is to increase awareness and understanding of them, followed by development of strategies to address them and to limit or eliminate their use in tobacco marketing...
- Youth access interventions do not affect youth smokingCaroline M Fichtenberg
Center for Tobacco Control Research and Education, Institute for Health Policy Studies, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 0130, USA
Pediatrics 109:1088-92. 2002..To determine the effectiveness of laws restricting youth access to cigarettes on prevalence of smoking among teens...
- Compliance with a minimum-age law of 18 for the purchase of tobacco--the case of SwedenMona Sundh
Public Health, Karlstad University, SE 651 88 Karlstad, Sweden
Health Educ Res 21:378-85. 2006..The study also indicates great potential for local efforts to induce more retailers to comply with the law...
- Tobacco, commercial speech, and libertarian values: the end of the line for restrictions on advertising?Ronald Bayer
Program in the History and Ethics of Public Health and Medicine, Division of Sociomedical Sciences, Mailman School of Public Health, Columbia University, 600 W 168th Street, New York, NY 10032, USA
Am J Public Health 92:356-9. 2002..In so doing, the court underscored the enduring tension between the libertarian and social welfare dimensions of contemporary democracy and placed into relief the divisions within the American liberal tradition...
- The Master Settlement Agreement and African Americans: opinions about the allocation of resourcesGary King
Pennsylvania State University, University Park, Pennsylvania, USA
Health Promot Pract 5:135S-142S. 2004..S. society...
- Corporate speech and the Constitution: the deregulation of tobacco advertisingLawrence O Gostin
Center for Law and the Public s Health, Georgetown University Law Center, 600 New Jersey Avenue NW, Washington, DC 20001, USA
Am J Public Health 92:352-5. 2002....
- Counteracting cigarette advertisingAlan B Morrison
Stanford Law School, 559 Nathan Way, Room 215, Stanford, CA 94305, USA
JAMA 287:3001-3. 2002
- Expressive freedom and tobacco advertising: a Canadian perspectiveChristopher P Manfredi
Department of Political Science, McGill University, 855 Sherbrooke Street, Montreal, Quebec, Canada H31 2T7
Am J Public Health 92:360-2. 2002..While the Canadian government could have used the decision to justify withdrawing from further confrontations with powerful commercial interests, it chose instead to enact new tobacco control legislation in 1997...
- Tobacco advertising in the United States: a proposal for a constitutionally acceptable form of regulationRonald Bayer
Mailman School of Public Health, Columbia University, 722 W 168th St, Ninth Floor, New York, NY 10032, USA
JAMA 287:2990-5. 2002..However, this would be a battle worth engaging, because it might have an impact on tobacco-related morbidity and mortality in the United States...
- Tobacco advertising and freedom of speechRichard J Bonnie
JAMA 288:1587; author reply 1587-8. 2002
- Tobacco advertising and freedom of speechTerence A Gerace
JAMA 288:1586; author reply 1587-8. 2002
- Will the master settlement agreement achieve a lasting legacy?Cheryl G Healton
American Legacy Foundation, Washington, DC, USA
Health Promot Pract 5:12S-17S. 2004..The inextricable link between Legacy, state tobacco control, and the politics of tobacco are discussed...
- Commentary: the Master Settlement Agreement in historic contextJohn Seffrin
American Cancer Society, National Home Office, Atlanta, Georgia, USA
Health Promot Pract 5:18S-20S. 2004
- Cochrane column: commentary: interventions for preventing tobacco sales to minorsDerek Yach
Global Public Health, Yale School of Public Health, USA
Int J Epidemiol 35:32. 2006
- Cigarette acquisition and proof of age among US high school students who smokeS Everett Jones
Division of Adolescent and School Health, National Center for Chronic Disease Prevention and Health Promotion NCCDPHP, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30341, USA
Tob Control 11:20-5. 2002..To determine how US high school students who are under 18 years of age and who smoke obtain their cigarettes and whether they are asked for proof of age...
- The effect of enforcement of the Master Settlement Agreement on youth exposure to print advertisingAlan Lieberman
California Attorney General s Tobacco Litigation and Enforcement Section, Sacramento, California, USA
Health Promot Pract 5:66S-74S. 2004....
- After the Master Settlement Agreement: trends in the American tobacco retail environment from 1999 to 2002Erin Ruel
Center for Demography of Health and Aging, University of Wisconsin Madison, USA
Health Promot Pract 5:99S-110S. 2004..Tobacco promotions in stores increased between 2001 and 2002. Stores in the south and rural areas tended to have the lowest prices and highest prevalence of promotions and advertising, suggesting a need for tobacco control intervention...
- [Social responsibility argument for the tobacco industry in Brazil]Tania Cavalcante
División del Control del Tabaquismo y otros factores de riesgo, Instituto Nacional del Cancer, Secretaria de Salud, Brasil
Salud Publica Mex 48:S173-82. 2006....
- Emerging technological approaches for controlling the hard core DUI offender in the U.SRobert B Voas
Pacific Institute for Research and Evaluation, Calverton, Maryland, USA
Traffic Inj Prev 5:309-16. 2004..Although those technologies offer considerable promise, they have not yet been evaluated in programs for impaired driving offenders. Eight issues related to the probability of rapid implementation of the new technologies are discussed...
- Is restricting tobacco sales the answer to adolescent smoking?M Staff
Public Health Unit, Northern Sydney Health, Sydney, Australia
Prev Med 37:529-33. 2003..There was no reduction in adolescent smoking with active enforcement of tobacco access laws despite an apparent increase in students who reported never to have smoked...
- [Cigarette smuggling: a wide scope phenomenon only there to serve the interests of big tobacco manufacturers]Louis Gauvin
Coalition Québecoise pour le Contróle du Tubac, Montreal, QC
Promot Educ . 2005....
- Tobacco compliance check in Hong KongMing yue Kan
Committee on Youth Smoking Prevention, Wan Chai, Hong Kong
Nicotine Tob Res 10:337-40. 2008..Periodic tobacco compliance checks should be adopted in Hong Kong to exert pressure on law enforcement bodies and tobacco retailers...
- A qualitative study of post-settlement influences on State tobacco control fundingJoy Austin-Lane
Department of Preventive Medicine and Biometrics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Health Promot Pract 5:46S-56S. 2004..A conceptual diagram is presented of all factors clustered into three categories. Further research is planned to quantify these factors and assess their explanatory value..
- An analysis of tobacco industry marketing to lesbian, gay, bisexual, and transgender (LGBT) populations: strategies for mainstream tobacco control and preventionPerry Stevens
Strategic Initiatives for the Tobacco Technical Assistance Consortium, Rollins School of Public Health, Emory University, Atlanta, Geaorgia, USA
Health Promot Pract 5:129S-134S. 2004..Reducing LGBT smoking rates is a public health challenge that will require exceeding the sense of validation tobacco advertising has created in LGBT communities...
- The 1998 Master Settlement Agreement: a public health opportunity realized--or lost?Dearell Niemeyer
Tobacco Technical Assistance Consortium, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Health Promot Pract 5:21S-32S. 2004..Moreover, tobacco companies have continued aggressive marketing efforts to reach youth...
- Identifying and responding to technical assistance and training needs in tobacco prevention and controlAmber Hardy Thornton
American Legacy Foundation, Washington, DC, USA
Health Promot Pract 5:159S-166S. 2004..Training and technical assistance can be the solution to sustaining impetus in the movement...
- Supporting and sustaining the tobacco control movementPaul Florin
University of Rhode Island, USA
Health Promot Pract 5:157S-158S. 2004
- More money more motivation? Master Settlement Agreement and tobacco control funding in communities of colorMakani Themba-Nixon
Praxis Project PATH, Washington, DC, USA
Health Promot Pract 5:113S-128S. 2004..Findings supported our hypothesis that there were few dedicated resources at the state level for tobacco control and prevention in communities of color...
- Advocating for dollars: unanticipated lessons in allocating Master Settlement Agreement fundsPhillip Wilbur
American Heart Association, Washington, DC, USA
Health Promot Pract 5:33S-34S. 2004
- Tobacco control in IndiaRiti Shimkhada
Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA
Bull World Health Organ 81:48-52. 2003..The Indian Government must also introduce policies to raise taxes, control smuggling, close advertising loopholes, and create adequate provisions for the enforcement of tobacco control laws...
- [War on Drugs or War against Health? The pitfalls for public health of Puerto Rican drug policy]Salvador Santiago-Negrón
Universidad Carlos Albizu, San Juan, Puerto Rico
P R Health Sci J 22:49-59. 2003..It also presents those principles that should sustain pragmatic drug policy to address problematic drug use from a health and social perspective...
- Underreporting of justifiable homicides committed by police officers in the United States, 1976-1998Colin Loftin
Violence Research Group, School of Criminal Justice, University at Albany, State University of New York, 12222, USA
Am J Public Health 93:1117-21. 2003..This study assessed the consistency of estimates of the number of justifiable homicides committed by US police officers and identified sources of underreporting...
- An example of international drug politics--the development and distribution of substance prevention programs directed at adolescentsJohn Lilja
Department of Biochemistry and Pharmacy, Abo Akademi University, Turku, Finland
Subst Use Misuse 42:317-42. 2007..A social competence framework might be used as both a goal and as a theoretical base to achieve a better understanding of the processes by which substance use prevention programs reach their effects...
- Youth targeting by tobacco manufacturers since the Master Settlement AgreementPaul J Chung
Department of Pediatrics, University of Chicago, USA
Health Aff (Millwood) 21:254-63. 2002..Banning all magazine advertising of cigarettes may be necessary to eliminate youth targeting in magazines...
- The shifting terrain of tobacco advertising since the Master Settlement AgreementTess B Cruz
Institute for Prevention Research, Keck School of Medicine, University of Southern California, Alhambra, California, USA
Health Promot Pract 5:64S-65S. 2004
- Exploring the rise in American pharmaceutical pricesAmitoi Marwaha
Medical College of Wisconsin, USA
Pharos Alpha Omega Alpha Honor Med Soc 65:11-5. 2002
- The Canadians are killing usRobert A Struble
Pharos Alpha Omega Alpha Honor Med Soc 65:58-9. 2002
- Criminal law, policing policy, and HIV risk in female street sex workers and injection drug usersKim M Blankenship
Department of Epidemiology and Public Health, Center for Interdisciplinary Research on AIDS, Yale University, USA
J Law Med Ethics 30:548-59. 2002
- American pharmaceutical pricesPeter Alagona
Pharos Alpha Omega Alpha Honor Med Soc 65:58. 2002
- The public health approach to motor vehicles, tobacco, and alcohol, with applications to firearms policyD Hemenway
Harvard Injury Control Research Center, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
J Public Health Policy 22:381-402. 2001..The endeavor to reduce gun violence is part of the general and continuing public health struggle to reduce harms caused by consumer products...
- From Asilomar to industrial biotechnology: risks, reductionism and regulationSheldon Krimsky
Department of Urban and Environmental Policy and Planning, Tufts University, Medford, MA 02155, USA
Sci Cult (Lond) 14:309-23. 2005
- Reflections on public bioethics: a view from the trenchesLeon R Kass
University of Chicago, IL, USA
Kennedy Inst Ethics J 15:221-50. 2005....
- State policies and nurses with substance use disordersMary R Haack
College of Nursing, Rutgers, State University of New Jersey, Newark, NJ, USA
J Nurs Scholarsh 34:89-94. 2002..To investigate the effects of two state regulatory policies on nurses with substance use disorders (SUD) on relapse rates and retention in the nursing workforce...
- Political attitudes vary with physiological traitsDouglas R Oxley
Department of Political Science, University of Nebraska Lincoln, Lincoln, NE 68588, USA
Science 321:1667-70. 2008....
- Reducing high-risk drinking by young Americans south of the border: the impact of a partial ban on sales of alcoholRobert B Voas
Pacific Institute for Research and Evaluation, Calverton, Maryland 20705, USA
J Stud Alcohol 63:286-92. 2002..Determine the effect of a partial sales ban on cross border drinking in Mexico...
- Effect of news coverage on the prevalence of drunk-driving behavior: evidence from a longitudinal studyItzhak Yanovitzky
Department of Communication, School of Communication Information and Library Studies, Rutgers University, New Brunswick, New Jersey 08091 1071, USA
J Stud Alcohol 63:342-51. 2002..To examine the proposition that antidrunk driving messages in the news media contributed indirectly to the decline in drunk driving over the past two decades through their impact on related policy making processes...
- A partial ban on sales to reduce high-risk drinking South of the border: seven years laterRobert B Voas
Pacific Institute for Research and Evaluation, 11710 Beltsville Drive, Suite 125, Calverton, Maryland 20705 3102, USA
J Stud Alcohol 67:746-53. 2006..The present study's objective was to determine the long-term (7-year) effect of the earlier-closing bar policy on cross-border drinking in Mexico...
- The future of tobacco regulation: a response to a proposal for fundamental institutional changeJonathan Liberman
VicHealth Centre for Tobacco Control, The Cancer Council Victoria, 100 Drummond Street, Carlton 3053, Victoria, Australia
Tob Control 15:333-8. 2006..We should be wary of allowing the understandable allure of new or radical approaches to distract us from this reality...
- Tobacco control in KoreaKiljun Park
College of Law, Yonsei University, Seoul, Korea
Med Law 23:759-80. 2004..It would be most proper to ratify the FCTC and abolish the Tobacco Business Act. Also, revision of the National Health Promotion Act is necessary to secure the enforcement and implementation of FCTC in Korea...
- [Tobacco control in South Africa]Corné van Walbeek
Ecole d Economie Université du Cap, Afrique du Sud
Promot Educ . 2005..The legislation clarifies and explains that the rights of non-smokers to clean air supersede the right of smokers to smoke. Smokers typically refrain from smoking where smoking is not allowed...
- Consequences of marketing exceptions in the Master Settlement Agreement: exposure of youth to adult-only tobacco promotionsKaren Bogen
Center for Survey Research, University of Massachusetts, Boston, MA 02125, USA
Nicotine Tob Res 8:467-71. 2006..In light of the large body of evidence that exposure to tobacco advertising and promotion increases tobacco use among youth, our findings demonstrate the need to close the "adult-only" loophole...
- Population receptivity to tobacco advertising/promotions and exposure to anti-tobacco media: effect of Master Settlement Agreement in California: 1992-2002Elizabeth A Gilpin
Department of Family and Preventive Medicine Moores Cancer Center, San Diego, California, USA
Health Promot Pract 5:91S-98S. 2004..These trends indicate less receptivity to tobacco advertising and promotions following the MSA but leave room for additional restrictions to further reduce receptivity...
- Nanny boo-boosJohn Leo
US News World Rep 134:12. 2003
- State and federal compliance with the Synar Amendment: federal fiscal year 1998J R DiFranza
Department of Family Medicine and Community Health, 55 Lake Ave, University of Massachusetts Medical School, Worcester, MA 01655, USA
Arch Pediatr Adolesc Med 155:572-8. 2001..This failure can be attributed to inadequate resources devoted to enforcement and reliance on merchant education in lieu of bona fide law enforcement...
- State tobacco excise taxes and adolescent smoking behaviors in the United StatesCarey Conley Thomson
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
J Public Health Manag Pract 10:490-6. 2004..These results support the inclusion of tobacco taxes in state tobacco control programs...
- Alcohol-impaired driving and its consequences in the United States: the past 25 yearsAllan F Williams
J Safety Res 37:123-38. 2006..Progress in dealing with the alcohol-impaired driving problem in the United States during the past 25 years is addressed...
- School smoking bans: do they help/do they harm?Christiane C Poulin
Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada
Drug Alcohol Rev 26:615-24. 2007..The purpose of the present study was to examine the association between school smoking bans and smoking initiation as a health outcome as well as academic achievement as an educational outcome, taking into account socio-economic status...
- School smoking bansRaoul A Walsh
Drug Alcohol Rev 27:570-1. 2008
- Aggressive crime, alcohol and drug use, and concentrated poverty in 24 U.S. urban areasAvelardo Valdez
Graduate School of Social Work, University of Houston, Houston, Texas 77204 4013, USA
Am J Drug Alcohol Abuse 33:595-603. 2007..Our findings tend to counter the cultural theorists who argue for an indigenous culture of violence in inner-city ghettos and barrios...
- Review of what youth programs do to increase the connectedness of youth with adultsJean B Grossman
Woodrow Wilson School, Princeton University, Princeton, New Jersey 08544, USA
J Adolesc Health 39:788-99. 2006..By connectedness, we mean primarily the attachment youth have to the adults in the programs...
- Images in public healthRobert Sember
Am J Public Health 93:1626-9. 2003
- Overlapping and complementary oxidative stress defense mechanisms in nontypeable Haemophilus influenzaeAlistair Harrison
The Center for Microbial Pathogenesis at the Research Institute at Nationwide Children s Hospital and the Center for Microbial Interface Biology and Department of Pediatrics, The Ohio State University, Ohio, USA
J Bacteriol 197:277-85. 2015..These mechanisms will be important for successful colonization and infection by this opportunistic human pathogen. ..
- Ctenopharyngodon idella IRF2 plays an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genesMeihui Gu
Department of Bioscience, College of Life Science, Nanchang University, Nanchang 330031, China
Dev Comp Immunol 49:103-12. 2015..1-IRF2 and pcDNA3.1-IRF1) were transiently co-transfected with pGL3-IFN or pGL3-CiPKZ into CIK cells, respectively. The results revealed that CiIRF2 plays an antagonistic role to CiIRF1 in transcriptional regulation of IFN and ISG genes...
- Core promoter short tandem repeats as evolutionary switch codes for primate speciationMina Ohadi
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Am J Primatol 77:34-43. 2015..We provide evidence of core promoter STRs as evolutionary switch codes for primate speciation, and the first instance of identity-by-descent for those motifs at the interspecies level...
- Genetic, molecular and clinical determinants for the involvement of aldosterone and its receptors in major depressionHarald Murck
Covance Inc, Princeton, N J, USA
Nephron Physiol 128:17-25. 2014....
- Combined experimental and bioinformatics analysis for the prediction and identification of VHR/DUSP3 nuclear targets related to DNA damage and repairFábio Luís Forti
Laboratory of Signalling in Biomolecular Systems, Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Av Prof Lineu Prestes, 748 Bl 09i, Sl 922, CEP 05508 900 Cidade Universitária, Sao Paulo SP, Brazil
Integr Biol (Camb) 7:73-89. 2015....
- Lipocalin-2 promotes m1 macrophages polarization in a mouse cardiac ischaemia-reperfusion injury modelL Cheng
Department of Gynaecology and Obstetrics, Xiangyan Central Hospital, Hubei University of Arts and Science, Xiangyang, China
Scand J Immunol 81:31-8. 2015..In conclusion, Lcn2 promotes M1 polarization, and Lcn2 neutralization attenuates cardiac IR injury. ..
- Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: role of heme oxygenase 1 in the second window of protectionShoichi Kageyama
Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Hepato Biliary Pancreatic and Breast Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
Liver Transpl 21:112-22. 2015..In conclusion, intestinal RIPC remarkably attenuates hepatic IRI in the SWOP, presumably by HO-1 induction in hepatocytes...
- Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugsDóra Dedinszki
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Cell Signal 27:363-72. 2015..These data imply the importance of PP1 inhibitory proteins in controlling the phosphorylation state of key proteins and regulating drug sensitivity and apoptosis in leukemic cells...
- Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in miceYan Lin
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China
Clin Exp Pharmacol Physiol 42:76-86. 2015..These results show that the anti-inflammation and regulation of tight junction proteins by Wharton's jelly-derived UMSC ameliorates colitis. ..
- Anchorage independency promoted tumor malignancy of melanoma cells under reattachment through elevated interleukin-8 and CXC chemokine receptor 1 expressionWu Ching Uen
aSchool of Medicine, FuJen Catholic University, New Taipei City bDepartment of Hematology and Oncology, Shin Kong Wu Ho Su Memorial Hospital, Taipei cNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
Melanoma Res 25:35-46. 2015..We show that the suspension of melanoma cells is critical in promoting melanoma malignancy in vivo and in vitro. ..
- Mineralocorticoid and SGK1-sensitive inflammation and tissue fibrosisFerruh Artunc
Department of Internal Medicine, University of Tubingen, Tubingen, Germany
Nephron Physiol 128:35-9. 2014..The untoward inflammatory and fibrosing effects of mineralocorticoids could be blunted or even reversed by mineralocorticoid receptor blockers, which may thus be considered in the treatment of inflammatory and/or fibrosing disease...
- ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injuryJ Rao
Liver Transplantation Center of First Affiliated Hospital and Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University, Nanjing, P R China Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing, P R China Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont UCLA Transplant Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
Am J Transplant 15:76-87. 2015..Our findings provide a rationale for a novel therapeutic strategy for managing IR-induced liver injury. ..
- Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxicationChing Yi Tsai
Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan, Republic of China
Biochem Pharmacol 93:34-41. 2015....
- On the pleotropic actions of mineralocorticoidsFlorian Lang
Department of Physiology, Eberhard Karls University of Tubingen, Tubingen, Germany
Nephron Physiol 128:1-7. 2014..Clearly, still much is to be learned about the various ramifications of mineralocorticoid-sensitive physiology and pathophysiology...
- Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRαJie Li
Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China
Biochem Pharmacol 93:92-103. 2015..RXRα mediates the sex-dependent influence of GH on CYP3A expression as an important signalling molecule. ..
- Effect of mineralocorticoids on acid-base balanceCarsten A Wagner
Institute of Physiology, University of Zurich, Zurich, Switzerland
Nephron Physiol 128:26-34. 2014..In patients with CKD, acidosis-induced aldosterone may contribute to progression of kidney disease. In summary, aldosterone is a powerful regulator of renal acid excretion required for normal acid-base balance...
- Combinatorial regulation of the dev operon by MrpC2 and FruA during Myxococcus xanthus developmentAshleigh Campbell
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA
J Bacteriol 197:240-51. 2015..This site is unique among the C-signal-dependent genes studied so far. Deletion of this site in the M. xanthus chromosome did not impair sporulation under laboratory conditions. ..
- Evaluation of developmental toxicity using undifferentiated human embryonic stem cellsEui Man Jung
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
J Appl Toxicol 35:205-18. 2015..Therefore, we suggest that hES cells may be useful for testing the toxic effects of chemicals that could impact the embryonic developmental stage...
- Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosomeSomsubhra Nath
Cancer Biology and Inflammatory Disorder Division, CSIR Indian Institute of Chemical Biology, Kolkata, India
Mol Cell Biol 35:356-69. 2015..We conclude that excess E2F1 due to Rb inactivation recruits the complex of Cdc20 and the anaphase-promoting complex/cyclosome (Cdc20-APC/C) to deregulate the expression of UBCH10, leading to chromosomal instability in cancer cells. ..
- Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cellsSara Bursomanno
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, DK 2200 Copenhagen, Denmark
DNA Repair (Amst) 25:84-96. 2015....
- Active heat shock transcription factor 1 supports migration of the melanoma cells via vinculin down-regulationAgnieszka Toma-Jonik
Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeze Armii Krajowej 15, 44 101 Gliwice, Poland Electronic address
Cell Signal 27:394-401. 2015..An apparent association between HSF1-induced down-regulation of vinculin, increased motility, and a reduced adherence of cells suggests a possible mechanism of HSF1-mediated enhancement of the metastatic potential of cancer cells...
- Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c releaseYueMei Zhang
Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
BMC Neurosci 6:13. 2005....
- The role of CT10 regulation of kinase-like in cancerChunmei Guo
Department of Biotechnology, Dalian Medical University, Dalian, China
Future Oncol 10:2687-97. 2014..The association of CRKL with malignant tumors and its potential action mechanisms were summarized. CRKL has the potential to be used as a biomarker for the diagnosis, treatment and prognosis of certain tumors...
- Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomyD Ripken
Top Institute of Food and Nutrition, Nieuwe Kanaal 9A, Wageningen, The Netherlands The Netherlands Organization for Applied Scientific Research, TNO, Zeist, The Netherlands Division of Human Nutrition, Wageningen University, Bomenweg 2, Wageningen, The Netherlands Electronic address
Physiol Behav 139:167-76. 2015..We conclude that regulation of liquid meal intake appears to be primarily regulated by CCK1 receptors not located on abdominal vagal nerve endings...
- The role of gut hormones in appetite regulation (review)G Marić
University of Belgrade Institute of Epidemiology, Faculty of Medicine Belgrade Serbia
Acta Physiol Hung 101:395-407. 2014....
- Acp70A regulates Drosophila pheromones through juvenile hormone inductionGwénaëlle Bontonou
CNRS UPR 9034, Universite de Paris Sud, 91198 Gif sur Yvette, France
Insect Biochem Mol Biol 56:36-49. 2015..Mating had negligible effects on CHC levels, however pheromone amounts were slightly reduced 3 and 4 days post copulation. The physiological significance of ACP70A on female pheromone synthesis is discussed...
- The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1Carina von der Lippen
Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, D 55099 Mainz, Germany
DNA Repair (Amst) 25:1-8. 2015..Our results reveal a strict control of base excision repair in cells of the human immune system. ..
- Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cellsSilvia Kurtovic
Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Microvasc Res 97:65-74. 2015..Leptin-mediated EC differentiation and angiogenesis in ESCs can be a useful application towards regenerative medicine and tissue engineering. ..
- AEG-1 3'-untranslated region functions as a ceRNA in inducing epithelial-mesenchymal transition of human non-small cell lung cancer by regulating miR-30a activityKunmei Liu
School of Life Science and Technology, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, China Ningxia Key Laboratory of Cerebrocranial Diseases, School of Laboratory Medicine, Ningxia Medical University, Yinchuan 750004, China
Eur J Cell Biol 94:22-31. 2015..In conclusion, our findings demonstrated a competitive endogenous RNAs regulatory network which will help understand the metastasis mechanisms of lung cancer and improve the prevention and treatment of lung cancer. ..
- Spatial analysis of gene regulation reveals new insights into the molecular basis of upper thermal limitsMarina Telonis-Scott
School of Biological Sciences, Monash University, Clayton, Vic, 3800, Australia
Mol Ecol 23:6135-51. 2014..Innate and induced transcriptome responses to hyperthermia are complex, and warrant moving beyond gene-level analyses. ..
- Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cellsMin Sup Lee
Department of Food Science and Nutrition, Pukyong National University, Busan 608 737, South Korea
Food Chem 174:538-46. 2015....
- Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8aDaesuk Chung
Division of Reproductive Sciences, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Mol Cell Endocrinol 400:48-60. 2015..Overall, stromal Fgf10 and Bmp8a serve as potential paracrine factors for E2-dependent regulation of epithelial proliferation in the uterus. ..
- D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress responseArmando Soto
Applied Biotechnology Branch, Division of Biosciences and Protection, Human Effectiveness Directorate, Air Force Research Laboratory, Area B, Wright Patterson Air Force Base, Dayton, OH 45433 5707, USA
Toxicology 243:177-92. 2008..Taken together, the results of this study provide important insights into the molecular mechanism of D-serine nephrotoxicity, as well as the activation of specific cellular pathways in response to this toxic insult...
- MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiotaNathan J Dennison
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
Dev Comp Immunol 49:170-8. 2015..Our study shows that A. gambiae aga-miR-305 regulates the anti-Plasmodium response and midgut microbiota, likely through post-transcriptional modification of immune effector genes...
- Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic strokeYi Je Chen
From the Department of Pharmacology Y J C, D P J, H W and Department of Physiology and Membrane Biology B K W, N Y, M E O, University of California, Davis
Stroke 46:237-44. 2015..This study evaluated whether KCa3.1 is expressed on and participates in BBB ion transport...
- Heat stress-induced Cup9-dependent transcriptional regulation of SIR2Shyamasree Laskar
Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India
Mol Cell Biol 35:437-50. 2015..The results of our study highlight the mechanism by which environmental factors amend the epigenetic configuration of chromatin. ..
- A developmentally inspired combined mechanical and biochemical signaling approach on zonal lineage commitment of mesenchymal stem cells in articular cartilage regenerationTahereh Karimi
Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Swearingen Engineering Center, Rm 2C11, Columbia, SC 29208, USA
Integr Biol (Camb) 7:112-27. 2015..Results demonstrate that a developmental approach with gradients in cell density, matrix stiffness, and zone-specific growth factors can potentially regenerate zonal structure of the articular cartilage. ..
- Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivoMagnus S AGren
Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Electronic address
Eur J Cell Biol 94:12-21. 2015..TNF-α had no significant effect on epidermal apoptosis. Our data indicate that TNF-α augments collagenolytic activity of MMP-1, possibly through up-regulation of MMP-3 leading to gradual loss of type I collagen in human skin. ..
- Regulation of MAP kinase signaling cascade by microRNAs in Oryza sativaBadmi Raghuram
a National Institute of Plant Genome Research New Delhi, India
Plant Signal Behav 9:e972130. 2014..Taken together, this report demonstrates the significance of miRNAs in regulation of the MAPK pathway in plants with a new direction to study the plant signaling molecules. ..
- Differential epithelial and stromal protein profiles in keratoconus and normal human corneasR Joseph
Department of Vision Sciences, University of Alabama at Birmingham, 924 18th Street South, Birmingham, AL 35294 4390, USA
Exp Eye Res 92:282-98. 2011..Additionally, because several epithelial and stromal enzymes exhibited up- or down-regulation in the KC corneas relative to normal corneas, the two layers of KC corneas were under metabolic stress to adjust their remodeling...
Research Grants110 found, 100 shown here
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Genetic variation and regulatory networks: Mechanisms and complexityDANA PE ER; Fiscal Year: 2009..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator ArraysRyan Bailey; Fiscal Year: 2009..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
- Novel TIRF microscopy analyzing trafficking & signaling at the cell cortexDerek Toomre; Fiscal Year: 2009..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
- Chymase-Mediated MMP Activation in Ishemia Reperfusion InjuryLOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013....
- Transcription factors regulating sensory gene expression and pain pathwaysEric E Turner; Fiscal Year: 2011..Together these studies will significantly advance our understanding of the molecular regulation of pain receptor pathways, which may form the basis for future pain treatments. ..
- Xenoestrogen regulation of Leydig cellsBENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
- Lauren Endres; Fiscal Year: 2014..Overall, these findings will form the basis of future studies into Abh8 regulation during the DDR. ..
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..We therefore believe the proposed work has the potential to have a significant impact on the health care of Veterans. ..
- SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016..The long-term goal is to identify the regulatory mechanisms to assist in the development of novel therapeutic protocols for better treatments. ..
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
- Mapping for Specialized Domains for FCeRI Signaling &InternalizationBridget S Wilson; Fiscal Year: 2013..Results of these analyses will contribute important new insight into the nature and assembly of membrane microdomains controlling immune cell signaling. ..
- MERVYN N WEITZMANN; Fiscal Year: 2016....
- Yun Fai Chris Lau; Fiscal Year: 2014..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
- The Primate Corpus Luteum: Functional Regression and Cardiovascular ImpactsRandy L Bogan; Fiscal Year: 2012..abstract_text> ..
- Jill M Wecht; Fiscal Year: 2014....
- Tibor T Glant; Fiscal Year: 2016....
- Carole R Mendelson; Fiscal Year: 2016....
- PHILIP LEE JOHNSON; Fiscal Year: 2016..This will allow me to make significant contributions to our knowledge of the neural and neurochemical mechanisms that lead to hot flashes and to identify potential novel nonhormonal targets for treatment. ..
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..The proposed studies will address important pathophysiological questions regarding the mechanisms regulating appetite and satiety as well as provide potentially important clinical treatment strategies. ..
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2012..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
- Role of Chromogranin A in Metabolic SyndromeSushil K Mahata; Fiscal Year: 2013..2. Evaluate the potential therapeutic effects of CST and its variants on insulin sensitivity and baroreflex sensitivity and heart rate variability in high fat diet-induced insulin resistant and in db/db diabetic mice. ..
- VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2014....
- FASEB SRC on Lysophospholipd Mediators in Health and DiseaseJulie D Saba; Fiscal Year: 2011....
- KRISTEN RACHEL VELLA; Fiscal Year: 2014..abstract_text> ..
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010..We hope the proposed studies will definitively validate galectin-3 as a target for treating atopic dermatitis and lead to the development of a novel therapy for this disease. ..
- Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of SclerodRobert B Zurier; Fiscal Year: 2012..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA). ..
- CRF-Oxytocin Interaction in the Regulation of Stress and AffectJoanna Dabrowska; Fiscal Year: 2013..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety. ..
- Patrice G Guyenet; Fiscal Year: 2015..This research focuses on specific neuronal networks located in the lower part of the brain called the medulla oblongata and its ultimate goal is to uncover novel treatments for OSA and other sleep-related respiratory disorders. ..
- Discovery of Small Molecule MBT Domain AntagonistsSTEPHEN VERNON FRYE; Fiscal Year: 2010..The chemical probes designed, synthesized and validated in this proposal will have applications in the discovery of molecular targets to treat diseases such as cancer and in the development of safe stem cell based therapeutics. ..
- Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junctionMartin A Smith; Fiscal Year: 2012..This novel signal pathway represents a new therapeutic target for the treatment of neuromuscular disease. ..
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
- Role of Txnip in adapting fuel metabolism to nutritional stateSIMON HUI; Fiscal Year: 2013..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans. ..
- Stephen E McGowan; Fiscal Year: 2016..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
- Impact of the P479L Variant in CPT1A on Infant Mortality in AlaskaDavid M Koeller; Fiscal Year: 2011..The results of this study will aid in the development of evidence-based guidelines for the treatment of Alaska Native infants diagnosed with CPT1A deficiency by newborn screening. ..
- The role of Fli1 in T cell function and the pathogenesis of lupusTamara K Nowling; Fiscal Year: 2011..Additionally, insight will be gained into the regulation of T cell function in both health and disease with relevance to an array of immune and neoplastic diseases. ..
- Randal J Kaufman; Fiscal Year: 2014..The proposed studies on protein synthesis will provide vital information that should encourage the development of novel therapeutics to treat diabetes. ..
- Role of SCD1 and Dietary Methionine Restriction on Energy HomeostasisERIC PAUL PLAISANCE; Fiscal Year: 2011....
- Lung Lysyl Oxidase Regulation by Metal Ion HomeostasisWande Li; Fiscal Year: 2013..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
- REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASESMelanie H Cobb; Fiscal Year: 2012..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
- Genetics and Haloperidol ResponseRobert J Hitzemann; Fiscal Year: 2012....
- RALPH FRANK FREGOSI; Fiscal Year: 2016..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
- Michael Demetriou; Fiscal Year: 2014..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
- Samantha M Yeligar; Fiscal Year: 2014..Thus, this K99/R00 application provides an excellent opportunity to advance the career of a talented and promising investigator. ..
- Bayar Thimmapaya; Fiscal Year: 2016....
- Translational Machinery in Stress Signaling and Tumor SuppressionTHOMAS J contact BEGLEY; Fiscal Year: 2010..The long term potential of the proposed research is significant, as understanding the mechanisms by which TRM9 inhibits tumor growth may provide novel therapeutic opportunities to restore growth-restricting programs in cancer cells. ..
- Role of Polyamines in MYCN-Amplified NeuroblastomaANDRE BACHMANN; Fiscal Year: 2009..Our research will be useful in the development of novel treatments for the most aggressive forms of the childhood cancer neuroblastoma. ..
- Patient-Derived Stem Cells for Phosphoproteomic Profiling NeuropsychopathologyDieter A Wolf; Fiscal Year: 2011....
- Mark W Chapleau; Fiscal Year: 2015..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
- Mitchell Kronenberg; Fiscal Year: 2014..This proposal will study the mechanisms by which the immune responses are properly controlled. Such knowledge will eventually facilitate the design of novel therapeutic approaches for immunological diseases. ..
- Donald A McClain; Fiscal Year: 2016..Initial exploration of mechanisms will include altered heme and NAD levels, the latter resulting in altered AMPK signaling. ..
- Insulin Signaling and the Heart in DiabetesEVAN DALE ABEL; Fiscal Year: 2011..Moreover, elucidation of the signaling mechanisms that regulate autophagy in cardiomyocytes may lead to novel therapies for preventing or modulating heart injury as occurs in diabetes, cardiac ischemia or cardiac hypertrophy. ..
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
- Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.ELIZABETH G SWEENEY; Fiscal Year: 2012..Cancro and Akintoe (my collaborators), and the numerous faculty members that I will interact with at the many journal club, seminar, and symposiums offered at Penn and the surrounding schools. ..
- Paul E Micevych; Fiscal Year: 2016..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
- Role of IKK in NSCLC: Modulation of SMRT and NF-kappaBMarty W Mayo; Fiscal Year: 2012..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
- DNA methylation of extracellular superoxide dismutase in pulmonary hypertensionEVA NOZIK GRAYCK; Fiscal Year: 2012..abstract_text> ..
- David A Bernlohr; Fiscal Year: 2014..If the hypothesis is proven to be correct, the study would be immediately translatable to human biology and afford a new view of how type 2 diabetes may be combated. ..
- Rac GTPase signaling during embryonic salivary gland branching morphogenesisSharon Sequeira; Fiscal Year: 2012....
- Junxuan Lu; Fiscal Year: 2014..These multiple targeting activities plus published work supporting anti- angiogenesis activity provide strong rationale for testing the efficacy of PGG for prostate cancer chemoprevention. ..
- Maria Diakonova; Fiscal Year: 2014..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
- Jianming Qiu; Fiscal Year: 2016..e., EPCs ex vivo-expanded under hypoxic conditions for B19V in this application. ..
- UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015..Pajvani will need in order to become an independent translational medical researcher and a productive member of the academic medical community. ..
- Analysis of gene regulation of Vibrio cholerae during infectionJun Zhu; Fiscal Year: 2013..cholerae in vivo survival strategies and shed new light on the host-pathogen interactions that underpin infections by related enteric bacterial pathogens. ..
- Christie P Thomas; Fiscal Year: 2014....
- Howard B Lieberman; Fiscal Year: 2016....
- ELIZABETH ANN EKLUND; Fiscal Year: 2016..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
- Rebecca A Simmons; Fiscal Year: 2016..The proof of the principle of prenatal programming by environmental contaminants may change our awareness of critical assessment of the risk of such compounds. ..
- Vickram Ramkumar; Fiscal Year: 2016..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
- Chou Zen Giam; Fiscal Year: 2014..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer ..
- Christin Carter-Su; Fiscal Year: 2016....
- RSK-2 regulates integrin-mediated adhesion and migrationJOE WILLIAM RAMOS; Fiscal Year: 2013..This will determine if these proteins are suitable targets for the development of new adhesion specific disease therapies. In particular we will test if RSK2 can serve as a potential new therapeutic target in glioma. ..
- Zhou Wang; Fiscal Year: 2014....
- SAMUEL BRANDON STEPHENS; Fiscal Year: 2015..Thus, through this award, I will gain training and generate crucial reagents necessary to launch my independent research program and obtain a tenure-track assistant professorship. ..
- Richard J Bram; Fiscal Year: 2015..These compounds will ultimately lead to establishing a novel approach for therapeutic treatment of GBM. In addition, they will have great utility as molecular probes to enhance studies defining the critical functions of CypB. ..
- ERIC KIRK LAU; Fiscal Year: 2014..abstract_text> ..
- Moosa Mohammadi; Fiscal Year: 2016..Since substrate recruitment and phosphorylation by RTKs is a general event in RTK signaling, the mechanistic insights gained under Aim IV will also be directly applicable to the entire RTK superfamily. ..
- John R Grider; Fiscal Year: 2016..The results would open a new field of study and point the way to new avenues of investigation for pharmacological agents to treat diarrhea and/or constipation. ..
- Claire Larmonier; Fiscal Year: 2014..Those specific aims will help address the following hypothesis: PARP1 contributes to aggravated mucosal immune response via modulation of inflammatory signaling pathways within the cells of the innate immune system. ..
- CLIFFORD JAMES ROSEN; Fiscal Year: 2015..Importantly, these studies will shed new light on the ErbB and Dock7 signaling pathways in bone and in BAT. Defining shared metabolic-skeletal networks may lead to new treatments for age-related osteoporosis. ..
- Heather R Burkin; Fiscal Year: 2015..Defining the integrin- mediated signaling pathways that regulate stretch induced activation of the uterine myometrium will have important implications for treating preterm and post term labor. ..
- Leena A Hilakivi-Clarke; Fiscal Year: 2015....
- Jeanette Gowen Cook; Fiscal Year: 2016....
- Paul M Lieberman; Fiscal Year: 2016..More detailed understanding of EBNA1 is further justified by its potential value as a target for therapeutic intervention in diseases and cancers associated with EBV latent infection. ..
- ALBERT HONG JAE KIM; Fiscal Year: 2016....
- ANASTACIA GRIEGO; Fiscal Year: 2016..Additionally, we will have learned critical aspects of the interplay between host and virus that may underlie progression to cancer and/or prognosis of HPV[+] lesions. ..
- Sihem Boudina; Fiscal Year: 2016..abstract_text> ..
- Identifying underlying mechanisms of intracellular changes in response to caregivMELANIE SARAH FLINT; Fiscal Year: 2013..The data obtained will be critical in identifying caregivers at risk for negative outcomes to improve overall caregiver health. ..
- Alexandra M Machikas; Fiscal Year: 2014..The findings from this study will be invaluable in establishing the phenotype of cell death characteristic of I/R injury in the aged female heart and may supply clear evidence of the mitochondria as a therapeutic target for AMI. ..
- KEVIN P CURRIE; Fiscal Year: 2014..This will provide the foundation for future expanded applications to investigate a new paradigm for 5HT / SERT mediated signal transduction. ..
- Paul Sumby; Fiscal Year: 2014..Public health may be enhanced through the long-term goal of translating knowledge of FASX regulatory pathways into new treatment and/or preventative regimes based upon the inhibition of these pathways by novel antimicrobial agents. ..