guam

Summary

Summary: An island in Micronesia, east of the Philippines, the largest and southernmost of the Marianas. Its capital is Agana. It was discovered by Magellan in 1521 and occupied by Spain in 1565. They ceded it to the United States in 1898. It is an unincorporated territory of the United States, administered by the Department of the Interior since 1950. The derivation of the name Guam is in dispute. (From Webster's New Geographical Dictionary, 1988, p471)

Top Publications

  1. pmc Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
    Paul Alan Cox
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 100:13380-3. 2003
  2. pmc A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam
    Susan J Murch
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 101:12228-31. 2004
  3. ncbi Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam
    S J Murch
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Acta Neurol Scand 110:267-9. 2004
  4. pmc Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam
    Peter J Schupp
    Marine Laboratory, University of Guam, Mangilao, Guam 96923
    Nat Prod Commun 4:1717-28. 2009
  5. ncbi A leptospirosis outbreak on Guam associated with an athletic event
    Robert L Haddock
    Office of Epidemiology and Research, Guam Department of Public Health and Social Services, Guam, USA
    Pac Health Dialog 9:186-9. 2002
  6. ncbi Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam
    Sandra Anne Banack
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, Kauai, HI 96741, USA
    Neurology 61:387-9. 2003
  7. ncbi Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros
    G E Kisby
    Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, Portland 97201
    Neurology 42:1336-40. 1992
  8. ncbi Incidence of amyotrophic lateral sclerosis and of the parkinsonism-dementia complex of Guam, 1950-1989
    Stephen C Waring
    Epidemiology Discipline, University of Texas School of Public Health, Houston, TX 77030, USA
    Neuroepidemiology 23:192-200. 2004
  9. ncbi Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
    Purnima Desai Sundar
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 16:295-306. 2007
  10. ncbi Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and parkinsonism-dementia complex of Guam: specific pathological features
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    J Neuropathol Exp Neurol 60:393-402. 2001

Detail Information

Publications194 found, 100 shown here

  1. pmc Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
    Paul Alan Cox
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 100:13380-3. 2003
    ..trophic levels of a food chain) of the neurotoxic nonprotein amino acid beta-methylamino-l-alanine (BMAA) in the Guam ecosystem. Free-living cyanobacteria produce 0...
  2. pmc A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam
    Susan J Murch
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 101:12228-31. 2004
    ..The biomagnification of BMAA through the Guam ecosystem fits a classic triangle of increasing concentrations of toxic compounds up the food chain...
  3. ncbi Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam
    S J Murch
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Acta Neurol Scand 110:267-9. 2004
    We tested the brain tissues of the Chamorro people of Guam who died of amyotrophic lateral sclerosis/Parkinsonism dimentia complex (ALS/PDC) for the neurotoxin beta-methylamino-l-alanine (BMAA)...
  4. pmc Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam
    Peter J Schupp
    Marine Laboratory, University of Guam, Mangilao, Guam 96923
    Nat Prod Commun 4:1717-28. 2009
    ..The overall high hit rate in many of the employed assays is considered to be a significant finding in terms of "normal" hit rates associated with similar samples from shallower depths...
  5. ncbi A leptospirosis outbreak on Guam associated with an athletic event
    Robert L Haddock
    Office of Epidemiology and Research, Guam Department of Public Health and Social Services, Guam, USA
    Pac Health Dialog 9:186-9. 2002
    Following an "extreme-adventure" athletic event on the island of Guam, 21 of 105 participants reported being ill. Three of 10 participants who reporting having a fever (temp > 101EF) had laboratory confirmed leptospirosis...
  6. ncbi Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam
    Sandra Anne Banack
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, Kauai, HI 96741, USA
    Neurology 61:387-9. 2003
    ..cycad seeds the flying foxes feed on, confirming the hypothesis that cycad neurotoxins are biomagnified within the Guam ecosystem...
  7. ncbi Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros
    G E Kisby
    Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, Portland 97201
    Neurology 42:1336-40. 1992
    ..Traditionally processed cycad flours (n = 17) obtained from Chamorro residents of Guam and the adjacent island of Rota at risk for neurodegenerative disease were extracted and analyzed by high-..
  8. ncbi Incidence of amyotrophic lateral sclerosis and of the parkinsonism-dementia complex of Guam, 1950-1989
    Stephen C Waring
    Epidemiology Discipline, University of Texas School of Public Health, Houston, TX 77030, USA
    Neuroepidemiology 23:192-200. 2004
    Studies representing the accumulated information from the first 30 years of research effort on Guam (1950-1979) have demonstrated a varying degree of decline in the incidence of amyotrophic lateral sclerosis (ALS) and the parkinsonism-..
  9. ncbi Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
    Purnima Desai Sundar
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 16:295-306. 2007
    Unusual forms of amyotrophic lateral sclerosis (ALS-G), Parkinsonism dementia complex (PDC-G) and Guam dementia (GD) are found in Chamorros, the indigenous people of Guam...
  10. ncbi Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and parkinsonism-dementia complex of Guam: specific pathological features
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    J Neuropathol Exp Neurol 60:393-402. 2001
    ..of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and parkinsonism-dementia complex of Guam (PDC); diseases in which the patients exhibit dementia and parkinsonism, with neurofibrillary tangles (NFTs) and ..
  11. pmc Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam
    Mark S Forman
    Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 160:1725-31. 2002
    ..complex (ALS/PDC) is a progressive neurodegenerative disorder of Chamorro residents of Guam and the Mariana Islands, characterized by abundant neuron loss and tau neurofibrillary pathology similar to that ..
  12. ncbi Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam
    Kiyomitsu Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Neuropathology 26:115-28. 2006
    ..The incidence on Guam was very high between 1950 and 1965 but decreased dramatically after 1965...
  13. ncbi Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex
    Matthew J Winton
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 111:401-12. 2006
    b>Guam parkinsonism-dementia complex (PDC) is a neurodegenerative tauopathy in ethnic Chamorro residents of the Mariana Islands that manifests clinically with parkinsonism as well as dementia and is characterized neuropathologically by ..
  14. ncbi Tau-positive fine granules in the cerebral white matter: a novel finding among the tauopathies exclusive to parkinsonism-dementia complex of Guam
    Mineo Yamazaki
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
    J Neuropathol Exp Neurol 64:839-46. 2005
    We examined the autopsied brains of cases of 6 types of tauopathy: parkinsonism-dementia complex of Guam (PDC), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick disease, Alzheimer disease (AD), and myotonic ..
  15. ncbi The nature of the parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam and magnesium deficiency
    Kiyomitsu Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Parkinsonism Relat Disord 11:S17-23. 2005
    ..the fatal neurological diseases, showing very high incidence during 1950-1970 and dramatic decrease after 1970 on Guam. Through the research, the present author insisted that; (1) NFTs in Guam ALS patients are merely a background ..
  16. ncbi New apratoxins of marine cyanobacterial origin from Guam and Palau
    Hendrik Luesch
    Department of Chemistry, University of Hawaii at Manoa, 96822, Honolulu, HI, USA
    Bioorg Med Chem 10:1973-8. 2002
    Two collections of the marine cyanobacterium Lyngbya sp. from Guam and Palau that both afforded the potent cytotoxin apratoxin A (1) each yielded different structural analogues with lower degrees of methylation...
  17. ncbi Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam
    A R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612 3805, USA
    Neurology 68:1764-71. 2007
    To study cycad-derived products as possible risk factors for dementia, mild cognitive impairment (MCI), and parkinsonism-dementia complex (PDC) on Guam.
  18. ncbi Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years
    Chris C Plato
    Department of Neurosciences, University of California San Diego School of Medicine, La Jolla 92093 0624, USA
    Am J Epidemiol 157:149-57. 2003
    ..amyotrophic lateral sclerosis (ALS, or Lytico) and parkinsonism-dementia complex (PDC, or Bodig) on the island of Guam was much higher than anywhere else in the world...
  19. ncbi Return of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?
    P G Ince
    Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield, Sheffield, UK
    Neuropathol Appl Neurobiol 31:345-53. 2005
    ..BMAA is reported in the brain tissue of Guam patients and early data suggest that some Northern American patients dying of Alzheimer's disease (AD) have ..
  20. pmc Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates
    Weiva Sieh
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 18:3725-38. 2009
    ..complex (ALS/PDC) is a fatal neurodegenerative disease found in the Chamorro people of Guam and other Pacific Island populations...
  21. ncbi Disease surveillance in Guam: a historical perspective
    Robert L Haddock
    Guam Department of Public Health and Social Services, Hagatna, Guam 96932, USA
    Pac Health Dialog 12:121-6. 2005
    ..active, and syndromic disease surveillance, together with disease registries and surveys, are undertaken by the Guam Department of Public Health and Social Services to provide a rational basis for decision making by health care ..
  22. ncbi Guam ALS/parkinsonism-dementia: a long-latency neurotoxic disorder caused by "slow toxin(s)" in food?
    P S Spencer
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, N Y 10461
    Can J Neurol Sci 14:347-57. 1987
    ..amyotrophic lateral sclerosis (ALS) that has occurred in high incidence among the Chamorro people of the islands of Guam and Rota in the Marianas chain of Micronesia...
  23. ncbi Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 4283, USA
    Acta Neuropathol 115:133-45. 2008
    ..Biochemical analyses showed the presence of FTLD-U-like insoluble TDP-43 in G-PDC, but not in Guam controls (G-C)...
  24. pmc Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
    Wan Yang
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 171:993-1002. 2007
    ..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
  25. ncbi A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam
    Manabu Wada
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Neurosci Lett 356:49-52. 2004
    ..sequence of proSAAS in the brains of patients with Alzheimer's disease and parkinsonism-dementia complex on Guam. The antibody against N-proSAAS immunostained neurofibrillary tangles and neuritic plaques in both diseases, ..
  26. ncbi Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases
    Walter G Bradley
    Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33136, USA
    Amyotroph Lateral Scler 10:7-20. 2009
    ..Research on Guam suggested that ALS, Parkinson's disease and dementia (the ALS/PDC complex) was due to a neurotoxic non-protein ..
  27. ncbi Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC)
    Judith Miklossy
    Kinsmen Laboratory of Neurological Research, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    Acta Neuropathol 116:625-37. 2008
    b>Guam ALS/PDC is a severe tangle forming disorder endemic to Guam with features overlapping such neurodegenerative disorders as Alzheimer disease (AD), Parkinson disease (PD), progressive supranuclear palsy (PSP), ALS, corticobasal ..
  28. ncbi Genome-wide analysis of the parkinsonism-dementia complex of Guam
    Huw R Morris
    Department of Molecular Pathogenesis and Sara Koe PSP Research Centre, Queen Square Brain Bank for Neurological Disorders, Insatitute of Neurology, University College London, London, England, UK
    Arch Neurol 61:1889-97. 2004
    ..It occurs in focal geographic isolates, including Guam and the Kii peninsula of Japan...
  29. ncbi Postencephalitic Parkinson's disease, amyotrophic lateral sclerosis on Guam and influenza revisited: focusing on neurofibrillary tangles and the trail of tau
    C P Maurizi
    Department of Pathology, Houston Medical Center, Warner Robins, GA 31093, USA
    Med Hypotheses 58:198-202. 2002
    ..links neuropathological changes in postencephalitic Parkinson's disease and amyotrophic lateral sclerosis on Guam to the 1918 influenza pandemic...
  30. ncbi Cancer on Guam, especially among Micronesians
    Robert L Haddock
    Office of Epidemiology and Research, Department of Public Health and Social Services, Hagatna, Guam, USA
    Pac Health Dialog 9:222-4. 2002
    The Guam Cancer Registry (GCR) collects data on cases of cancer in Guam residents whether their initial diagnosis is made on Guam or as a result of a referral to an off-island medical facility...
  31. ncbi Highlights of findings from the 1999 Guam study of youth risk behaviors
    Randall L Workman
    University of Guam, College of Agriculture and Life Sciences Community Resource Development, UOG Station, Mangilao, Guam 96923, USA
    Pac Health Dialog 9:233-6. 2002
  32. ncbi Living the health transition among the Chamorros of Guam
    Vicki Torsch
    Dept of Anthropology, University of Vermont, Williams Hall, Burlington, VT 05405 0168, USA
    Pac Health Dialog 9:263-74. 2002
    ..This paper focuses on the health transition of the Chamorros of Guam, blending assessment of health trends with the cultural contexts associated with them...
  33. ncbi Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000
    John Hardy
    Neurology 59:1121; author reply 1121. 2002
  34. ncbi Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam
    Paul Alan Cox
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, Kauai, HI 96741, USA
    Neurology 58:956-9. 2002
    The Chamorro people of Guam have been afflicted with a complex of neurodegenerative diseases (now known as ALS-PDC) with similarities to ALS, AD, and PD at a far higher rate than other populations throughout the world...
  35. ncbi A clinical and pathological study of motor neurone disease on Guam
    H R Morris
    Neurogenetics Section, University Department of Clinical Neurology, Reta Lila Weston Institute of Neurological Sciences, University College London, London, UK
    Brain 124:2215-22. 2001
    Despite over 40 years of intensive study, the cause of the high incidence of motor neurone disease (MND) on Guam, and the relationship between this disease and MND seen in the rest of the world are still uncertain...
  36. ncbi A commentary on neuronal degeneration and cell death in Guam ALS and PD: an evolutionary process of understanding
    Ralph M Garruto
    Laboratory of Biomedical Anthropology and Neurosciences, State University of New York at Binghamton, Binghamton, New York 13902 6000, USA
    Curr Alzheimer Res 3:397-401. 2006
    ....
  37. ncbi Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000
    D Galasko
    Department of Neurosciences, University of California, San Diego, USA
    Neurology 58:90-7. 2002
    ..high-incidence ALS and Parkinson-dementia complex (PDC) were identified among Chamorros, the native inhabitants of Guam. Brains of patients with these syndromes showed widespread neurofibrillary tangles...
  38. ncbi Skeletal biology of Apurguan: a precontact Chamorro site on Guam
    M T Douglas
    Department of Anthropology, University of Hawai i Manoa, Honolulu 96822, USA
    Am J Phys Anthropol 104:291-313. 1997
    The human skeletal remains of a minimum of 152 individuals from the precontact Latte Period (AD 1000-1521) on Guam, Mariana Islands, are described...
  39. ncbi Prevalence of dementia in Chamorros on Guam: relationship to age, gender, education, and APOE
    D Galasko
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neurology 68:1772-81. 2007
    To estimate the prevalence of dementia and its clinical subtypes among Chamorros on Guam aged 65 years or older and to examine associations with age, gender, education, and APOE genotype.
  40. ncbi Comparative analysis of oral health indicators among young children in Hawai'i, the Republic of Palau and Territory of Guam, 1999-2000
    Mark H K Greer
    Dental Health Division, Department of Health, State of Hawai i, Honolulu, Hawai i, USA
    Pac Health Dialog 10:6-11. 2003
    Dental caries prevalence data were collected in Hawai'i, Palau and Guam and analyzed for dft, DMFT, unmet treatment needs, sealant utilization and various caries patterns...
  41. pmc Cancer-related knowledge, attitudes, and behaviors among Chamorros on Guam
    Ronald G Balajadia
    Department of Public Health and Social Services, Agana, Guam
    Cancer Detect Prev 32:S4-15. 2008
    Cancer is the second leading cause of death among Chamorros, the indigenous population of Guam. This study assessed cancer-related knowledge, attitudes, and preventive behaviors (KAB) among Chamorros on the island.
  42. ncbi Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment
    Venkat R Macherla
    Nereus Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Nat Prod 70:1454-7. 2007
    ..NPS008920, a member of the new genus Marinispora, was isolated from a sediment sample collected in Cocos Lagoon, Guam. In natural sea water containing media, the strain produced a series of novel 2-alkylidene-5-alkyl-4-oxazolidinones,..
  43. ncbi Cycad neurotoxin, consumption of flying foxes, and ALS/PDC disease in Guam
    Kwang Ming Chen
    Neurology 59:1664; author reply 1664-5. 2002
  44. ncbi Epidemiology of infants of diabetic mothers in indigent Micronesian population-Guam experience
    Pradeep Alur
    Guam Memorial Hospital Authority, Guam, USA
    Pac Health Dialog 9:219-21. 2002
    Diabetes complicating pregnancy has not yet been properly evaluated in Guam and the prevalence and morbidity of infants of diabetic mothers (IDM) in Micronesian population on Guam is described...
  45. ncbi Parkinsonism-dementia complex of Guam
    John C Steele
    Micronesian Health Study II, Tamuning, Guam
    Mov Disord 20:S99-S107. 2005
    On Guam and in two other Pacific locales, indigenous residents and immigrants are prone to familial neurodegeneration that manifests as atypical parkinsonism, dementia, motor neuron disease, or a combination of these three phenotypes...
  46. ncbi The ALS/PDC syndrome of Guam and the cycad hypothesis
    John C Steele
    Guam Memorial Hospital, Agana
    Neurology 70:1984-90. 2008
    There is a high incidence on Guam of a severe tauopathy known as the Parkinson- dementia complex (PDC). It is linked with an even more malignant amyotrophic lateral sclerosis (ALS) syndrome...
  47. ncbi Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and Parkinsonism-dementia complex of Guam determined by High-resolution ICP-MS
    Kristin Gellein
    Department of Chemistry, Norwegian University of Science and Technology, Trondheim, Norway
    Biol Trace Elem Res 96:39-60. 2003
    ..PDC) are neurodegenerative disorders that occurred with extremely high frequency among the native population on Guam, especially in the 1950s and 1960s, but have substantially declined over the last half-century...
  48. ncbi [Lessons from Guam ALS/PDC study]
    Hirano Asao
    Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Rinsho Shinkeigaku 47:717-21. 2007
    ..ALS) and parkinsonism-dementia complex (PDC) affecting the native population was discovered on the island of Guam a half century ago...
  49. ncbi Animal models of BMAA neurotoxicity: a critical review
    Vardan T Karamyan
    Department of Pharmacology, School of Pharmacy, University of Mississippi, MS 38677, USA
    Life Sci 82:233-46. 2008
    ..In the late 1960's it was reported to be a toxic component of the cycad flour consumed by Chamorros on Guam which caused the high incidence of amyotrophic lateral sclerosis (ALS) in Guam, that was associated with a ..
  50. ncbi Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults
    J A Kaye
    Departments of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurology 69:196-9. 2007
    We sought to determine if Chamorro individuals with a family history of Guam dementia (GD) or Parkinson dementia complex (PDC) exhibit presymptomatic brain MRI changes...
  51. ncbi [Parkinsonism-dementia complex on Guam]
    Nobuyuki Murakami
    Department of Neurology, Kariya General Hospital, Toyota Medical Corporation
    Nihon Rinsho 62:118-21. 2004
  52. ncbi Commentary on: Return of the cycad hypothesis--does the amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?
    P A Cox
    Neuropathol Appl Neurobiol 32:679-82. 2006
  53. ncbi Is there a role for naturally occurring cyanobacterial toxins in neurodegeneration? The beta-N-methylamino-L-alanine (BMAA) paradigm
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Room 4004, 1501 NW 9th Avenue, Miami, FL 33136, USA
    Neurochem Int 50:998-1003. 2007
    ..such as the Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex (ALS/PDC) in the South Pacific island of Guam and in a small number of Caucasian, North American patients with sporadic Alzheimer's disease...
  54. pmc A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders
    Meredith C Hermosura
    Bekesy Laboratory of Neurobiology, Pacific Biosciences Research Center, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Proc Natl Acad Sci U S A 102:11510-5. 2005
    ..This study represents an initial attempt to address the important issue of gene-environment interactions in the etiology of these diseases...
  55. ncbi A link between ALS and short residence on Guam
    Danielle Majoor-Krakauer
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 64:1819-20. 2005
  56. ncbi Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 65:768-9. 2005
    ..In contrast to others, they detected no free BMAA in any of these samples...
  57. ncbi Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide?
    Greg Miller
    Science 313:428-31. 2006
  58. ncbi Elevated levels of ferrimagnetic metals in foodchains supporting the Guam cluster of neurodegeneration: do metal nucleated crystal contaminants [corrected] evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?
    Mark Purdey
    High Barn Farm, Elworthy, Taunton, Somerset TA4 3PX, UK
    Med Hypotheses 63:793-809. 2004
    ..clusters of Alzheimer (AD), Parkinson-like (PD), motor neurone diseases and multiple sclerosis on the island of Guam. Soils drawn from the cluster region demonstrated an excessive fivefold increase in 'magnetic susceptibility' ..
  59. ncbi Neurodegenerative disease. From cycad flour, a new suspect emerges
    Greg Miller
    Science 313:431. 2006
  60. ncbi Debating the cause of a neurological disorder
    Mark W Duncan
    Science 313:1737. 2006
  61. ncbi [Changes in neurological diseases during the last half century. Neuropathological view point]
    Asao Hirano
    Rinsho Shinkeigaku 43:732-7. 2003
    ..been studying the neuropathology of fatal neurodegenerative diseases endemic to the native Chamorro population on Guam during the last half century...
  62. ncbi Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex
    Joseph Sebeo
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1134, New York, NY 10029, USA
    Acta Neuropathol 107:497-503. 2004
    ..complex (ALS/PDC) is a progressive neurodegenerative disease affecting the indigenous Chamorro population of Guam. Neuropathologically, PDC is characterized by neuronal loss in the substantia nigra pars compacta with severe ..
  63. ncbi [Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam]
    Hitoshi Okumura
    Department of Neurology, Tomakomai City Hospital
    Nihon Rinsho 62:136-40. 2004
  64. ncbi Amyotrophic lateral sclerosis and diabetes on Guam: changing patterns of chronic disease in an island community
    Robert L Haddock
    Guam Department of Public Health and Social Services, Hagatna, Guam, USA
    Southeast Asian J Trop Med Public Health 34:659-61. 2003
    Amyotrophic lateral sclerosis (ALS) occurred on the island of Guam with unusually high incidence rates for many years but began to disappear with the island's westernization after WW II...
  65. ncbi Western Pacific ALS/PDC and flying foxes: What's next?
    Carmel Armon
    Neurology 61:291-2. 2003
  66. ncbi Toxicology. Fruit bats linked to mystery disease
    Richard Stone
    Science 296:241. 2002
  67. ncbi Neurofibrillary tangles in the primary motor cortex in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Box 1639, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 328:294-8. 2002
    ..complex is a chronic neurodegenerative disorder with high prevalence among the native Chamorro population of Guam. The cortical pathology of the disease is characterized by the widespread occurrence of cortical neurofibrillary ..
  68. ncbi Is somatosensory function abnormal in amyotrophic lateral sclerosis/parkinsonism-dementia complex in Kii Peninsula?
    Hiroshi Shibasaki
    Clin Neurophysiol 114:775-6. 2003
  69. ncbi Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex
    I Khabazian
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    J Neurochem 82:516-28. 2002
    The factors responsible for ALS-parkinsonism dementia complex (ALS-PDC), the unique neurological disorder of Guam, remain unresolved, but identification of causal factors could lead to clues for related neurodegenerative disorders ..
  70. ncbi [A historical note on the research for amyotrophic lateral sclerosis in Japan]
    Toru Mannen
    Rinsho Shinkeigaku 42:1040-3. 2002
  71. ncbi Progressive supranuclear palsy and its relation to pacific foci of the parkinsonism-dementia complex and Guadeloupean parkinsonism
    John C Steele
    Micronesian Health Study II, 515 Alupang Cove, Tamuning 96913, Guam
    Parkinsonism Relat Disord 9:39-54. 2002
    ..Others have a clinical syndrome of atypical parkinsonism that resembles the parkinsonism-dementia complex (PDC) of Guam and the Kii peninsula of Japan (PDC)...
  72. ncbi ALS and PDC of Guam: forty-year follow-up
    C C Plato
    Department of Neurosciences, University of California San Diego School of Medicine, La Jolla 92093 0624, USA
    Neurology 58:765-73. 2002
    ..was noticed in the mid-1950s that the incidence of ALS and parkinsonism--dementia complex (PDC) were much higher on Guam than anywhere else in the world...
  73. ncbi Epidemiological and clinical patterns of western pacific amyotrophic lateral sclerosis (ALS) in Guam and sporadic ALS in Rochester, Minnesota, U.S.A. and Hokkaido, Japan: a comparative study
    Hitoshi Okumura
    Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Hokkaido Igaku Zasshi 78:187-95. 2003
    Western Pacific amyotrophic lateral sclerosis (ALS) in Guam, so-called Guam ALS, is a neurodegenerative disease with a high incidence among the indigenous population, Chamorros, in Guam...
  74. ncbi TAU as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam
    P Poorkaj
    Geriatric Research Education Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Arch Neurol 58:1871-8. 2001
    BACKGROUND: A Guam variant of amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia complex (PDC-G) are found in the Chamorro people of Guam...
  75. ncbi Spinal cord neurofibrillary pathology in Alzheimer disease and Guam Parkinsonism-dementia complex
    M L Schmidt
    Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia 19104-4283, USA
    J Neuropathol Exp Neurol 60:1075-86. 2001
    We examined spinal cords of neurodegenerative disease patients and controls living on the Island of Guam and in the continental United States...
  76. ncbi Global youth tobacco surveillance, 2000-2007
    Charles W Warren
    Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA 30341, USA
    MMWR Surveill Summ 57:1-28. 2008
    ....
  77. ncbi [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]
    F J Carod-Artal
    Servicio de Neurologia, Hospital Sarah, Brasilia DF, Brasil
    Rev Neurol 36:860-71. 2003
    ..A wide range of plants, seeds and fruits used for nutritional and medicinal purposes can give rise to neurotoxic symptoms...
  78. ncbi Cancer epidemiology in the pacific islands - past, present and future
    Malcolm A Moore
    UICC Asian Regional Office for Cancer Control
    Asian Pac J Cancer Prev 11:99-106. 2010
    ..New Caledonia, Fiji, Polynesia, French Polynesia, Maori in New Zealand, Native Hawaiians, Micronesia, including Guam, and Aboriginal populations in Australia as assessed by PubMed searches and perusal of the International Agency for ..
  79. ncbi Surveillance of certain health behaviors and conditions among states and selected local areas - Behavioral Risk Factor Surveillance System, United States, 2007
    Pranesh Chowdhury
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA 30341, USA
    MMWR Surveill Summ 59:1-220. 2010
    ..Monitoring health-risk behaviors, chronic health conditions, and preventive care practices is essential to develop health promotion activities, intervention programs, and health policies at the state, city, and county levels...
  80. ncbi Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy
    Dominique Caparros-Lefebvre
    Neurologie, Centre Hospitalier Universitaire de la Guadeloupe, Pointe a Pitre, French West Indies
    Brain 125:801-11. 2002
    ..This new focus of atypical parkinsonism is reminiscent of the one described in Guam and may be linked to exposure to tropical plants containing mitochondrial complex I inhibitors (quinolines, ..
  81. ncbi Tobacco smoking prevalence in Pacific Island countries and territories: a review
    Kumanan Rasanathan
    Section of Pacific and International Health, School of Population Health, University of Auckland, Auckland, New Zealand
    N Z Med J 120:U2742. 2007
    ..To comprehensively review adult and youth smoking prevalence data in Pacific Island countries and territories (PICT)...
  82. ncbi Isolation by distance and vicariance drive genetic structure of a coral reef fish in the Pacific Ocean
    S Planes
    Ecole Pratique des Hautes Etudes ESA CNRS 8046, Universite de Perpignan, France
    Evolution 56:378-99. 2002
    ..The genetic structure revealed five geographic groups in the Pacific Ocean: western Pacific (Guam, Philippines, Palau, and Great Barrier Reef); central Pacific (Solomons, New Caledonia, and Fiji); and three groups ..
  83. pmc Reducing cancer health disparities in the US-associated Pacific
    JoAnn U Tsark
    Imi Hale Native Hawaiian Cancer Network, Honolulu, Hawaii 96813, USA
    J Public Health Manag Pract 13:49-58. 2007
    ..control capacity in the US-associated Pacific Islands (USAPI, including American Samoa, Northern Mariana Islands, Micronesia, Guam, Marshall Islands, and Palau) and to support indigenous leadership in reducing cancer health disparities.
  84. pmc Cryptic diversity, molecular phylogeny and biogeography of the rock- and leaf litter-dwelling land snails of Belau (Republic of Palau, Oceania)
    Rebecca J Rundell
    Committee on Evolutionary Biology, University of Chicago, 1025 East 57th Street, Chicago, IL 60637, USA
    Philos Trans R Soc Lond B Biol Sci 363:3401-12. 2008
    ..Diplommatinid species from the islands of Yap, Pohnpei, Kosrae and Guam are also included in the analysis...
  85. pmc Geographic variation in venom allelic composition and diets of the widespread predatory marine gastropod Conus ebraeus
    Thomas F Duda
    Department of Ecology and Evolutionary Biology and Museum of Zoology, University of Michigan, Ann Arbor, MI, USA
    PLoS ONE 4:e6245. 2009
    ..Because Conus venoms are used primarily to subdue prey, the evolution of venoms is likely affected by predator-prey interactions...
  86. ncbi Atypical unclassifiable parkinsonism on Guadeloupe: an environmental toxic hypothesis
    Dominique Caparros-Lefebvre
    Centre Hospitalier de Valenciennes, France
    Mov Disord 20:S114-8. 2005
    ..Most patients closely resemble descriptions of bodig from Guam. In both geographic isolates, an environmental cause has been discussed...
  87. ncbi Predatory response of brown tree snakes to chemical stimuli from human skin
    Michael J Greene
    Department of Zoology, Oregon State University, 3029 Cordley Hall, Corvallis, Oregon 97331 2914, USA
    J Chem Ecol 28:2465-73. 2002
    The brown tree snake (Boiga irregularis) is an exotic pest species on Pacific islands, most notably on Guam where it has caused considerable ecological and economic damage...
  88. ncbi Contraceptive use--United States and territories, Behavioral Risk Factor Surveillance System, 2002
    Diana M Bensyl
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia, USA
    MMWR Surveill Summ 54:1-72. 2005
    ..Information about contraceptive use for specific subpopulations can be used to further refine state efforts to improve contraceptive use and subsequently decrease the occurrence of unintended pregnancy...
  89. ncbi An assessment of health and disease in the prehistoric inhabitants of the Mariana Islands
    M Pietrusewsky
    Department of Anthropology, University of Hawai i Manoa, Honolulu 96822, USA
    Am J Phys Anthropol 104:315-42. 1997
    ..The major skeletal series surveyed include sites on Guam (N = 247 individuals), Rota (N = 14), Tinian (N = 20), and Saipan (N = 102)...
  90. pmc Expressed sequence tag analysis in Cycas, the most primitive living seed plant
    Eric D Brenner
    The New York Botanical Garden, 200th Street and Kazimiroff, Bronx, NY 10458 5126, USA
    Genome Biol 4:R78. 2003
    ..Cycads have also been implicated as the source of 'Guam's dementia', possibly due to the production of S(+)-beta-methyl-alpha, beta-diaminopropionic acid (BMAA), which is ..
  91. ncbi Chronic barium intoxication disrupts sulphated proteoglycan synthesis: a hypothesis for the origins of multiple sclerosis
    Mark Purdey
    High Barn Farm, Elworthy, Taunton, Somerset TA43PX, UK
    Med Hypotheses 62:746-54. 2004
    ..Analyses of ecosystems supporting the most renowned MS clusters in Saskatchewan, Sardinia, Massachusetts, Colorado, Guam, NE Scotland demonstrated consistently elevated levels of Ba in soils (mean: 1428 ppm) and vegetation (mean: 74 ppm)..
  92. ncbi Assessing physicians' continuing medical education (CME) needs in the U.S.-associated Pacific jurisdictions
    Matthew J Thompson
    WWAMI Center for Health Workforce Studies and Department of Family Medicine, University of Washington, Seattle, WA, 98195 4696, USA
    Pac Health Dialog 9:11-6. 2002
    ..the self-perceived continuing medical education (CME) needs of physicians in American Samoa, Commonwealth of the Northern Mariana Islands, Guam, Federated States of Micronesia, Republic of the Marshall Islands, and the Republic of Palau.
  93. ncbi Prevention of mother to child transmission of HIV infection in Pacific countries
    P Rupali
    Department of Adult Infectious Diseases, Starship Children s Health, Aukland Hosptial, Aukland, New Zealand
    Intern Med J 37:216-23. 2007
    ..The limited health infrastructure present in some PICT may delay the implementation of effective programmes to decrease MTCT of HIV...
  94. ncbi Venom of the Brown Treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity
    Stephen P Mackessy
    School of Biological Sciences, University of Northern Colorado, 501 20th Street, CB 92, Greeley, CO 80639 0017, USA
    Toxicon 47:537-48. 2006
    ..Boiga irregularis), a rear-fanged member of the polyphyletic family Colubridae, is an introduced predator on Guam which has been responsible for numerous human envenomations...
  95. ncbi Passive acoustic monitoring of marine ecosystems in the Pacific Islands Region
    Marc O Lammers
    Joint Inst for Marine and Atmospheric Res, NOAA CRED, 1125B Ala Moana Blvd, Honolulu, HI 96814, Fisheries, Honolulu, HI 96814Univ of Hawaii, Kailua, HI 96734Joint Inst for Marine and Atmos Res, Honolulu, HI 96814
    J Acoust Soc Am 125:2547. 2009
    ..stations and spans the Hawaiian Archipelago, American Samoa, the Line Islands, Johnston Atoll, Wake Atoll, Guam, and the Commonwealth of the Northern Mariana Islands...
  96. ncbi Diabetes today in the Pacific: reports from the field
    Nia T Aitaoto
    The Pacific Diabetes Today Resource Center PDTRC of Papa Ola Lokahi, Honolulu, HI, USA
    Pac Health Dialog 12:124-31. 2005
    ..Diabetes Today Resource Center (PDTRC) was established in 1998 to assist communities in Hawai'i, American Samoa, Guam, Commonwealth of the Northern Mariana Islands, Republic of Palau, Federated States of Micronesia, and the Republic ..
  97. ncbi Trend analysis of diagnosed diabetes prevalence among American Indian/Alaska native young adults--United States, 1994-2007
    Henry Roberts
    Centers for Disease Control and Prevention, National Center for Chronic Disease and Health Promotion, Division of Adult and Community Health Atlanta, GA 30333, USA
    Ethn Dis 19:276-9. 2009
    ....
  98. ncbi Inflammation and the degenerative diseases of aging
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
    Ann N Y Acad Sci 1035:104-16. 2004
    ..disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, the Parkinson-dementia complex of Guam, all of the tauopathies, and age-related macular degeneration...
  99. ncbi Empowerment through community building: Diabetes Today in the Pacific
    Kathryn L Braun
    Pacific Diabetes Today Resource Center, Papa Ola Lokahi, 894 Queen Street, Honolulu, HI 96813, USA
    J Public Health Manag Pract . 2003
    ..Resource Center (PDTRC) in 1998 to tailor the program for Pacific Islander communities in Hawaii, American Samoa, Guam, the Commonwealth of the Northern Marianas Islands, the Federated States of Micronesia, the Republic of the ..
  100. ncbi NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC)
    Osamu Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Acta Neuropathol 104:333-41. 2002
    ..dementia with Lewy bodies, Alzheimer's disease, multiple system atrophy and parkinsonism-dementia complex of Guam. To clarify whether alphaS accumulates in other neurodegenerative disorders, we investigated eight DNTC brains ..
  101. ncbi Health-related quality of life and health risk behaviors among smokers
    Tara W Strine
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Prev Med 28:182-7. 2005
    ..It is well established that smoking has detrimental effects on physical health, but its associations with health-related quality of life (HRQOL) and a variety of health behaviors have not been widely investigated in the U.S. population...

Research Grants7

  1. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..The existence of high incidence foci of motor neuron diseases among human populations (e.g. the Guam amyotrophic lateral sclerosis, konzo, and/or lathyrism) suggests that environmental factors e.g...
  2. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The UOG Endowment Foundation in collaboration with the Guam Medical Association will convene Health Care Disparities in the Pacific Islands, the first Pacific Region Medical Conference scheduled for ..
  3. CALMODULIN DEPENDENT KINASE AND SYNAPTIC FUNCTION
    MARY VALLANO; Fiscal Year: 1992
    ..of several neurological disorders where alterations in the neuronal cytoskeleton and/or synaptic neurotransmission are observed, including Alzheimer's disease, epilepsy amyotrophic lateral sclerosis and the Guam form of Parkinsonism.
  4. Guam's Hospital & Nursing Facility Internet Connectivity
    MAX PALISSON; Fiscal Year: 2001
    ..secure and reliable Internet connectivity for two public medical facilities on the United States territory of Guam: the only civilian hospital, Guam Memorial Hospital Authority (GMHA) and the long-term care Skilled Nursing ..
  5. PILOT STUDY FOR THE WOMEN PHYSICIANS' HEALTH STUDY
    ELIZABETH HOLLY; Fiscal Year: 1993
    ..aims: First, we will obtain names, addresses, birth dates and race for women physicians in the United States, Guam, Puerto Rico and the Virgin Islands...
  6. Univ. of Guam/Cancer Res. Center of Hawaii Partnership
    Carl Wilhelm Vogel; Fiscal Year: 2009
    The University of Guam (UOG) is the only four-year institution of higher learning in the Western Pacific serving the U.S. territories of Guam and the Commonwealth of the Northern Mariana Islands, as well as all of Micronesia...
  7. Preventing Bleeding Disorder Complications thru Hemophilia Tx Ctrs in Region IX
    Diane J Nugent; Fiscal Year: 2010
    ..the complications of inherited bleeding disorders among residents of Region DC - California, Hawaii, Nevada and Guam. This will be accomplished by continued implementation of diagnostic, clinical management, education, outreach, ..