subacute sclerosing panencephalitis

Summary

Summary: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)

Top Publications

  1. ncbi Clinical presentation of subacute sclerosing panencephalitis in Papua New Guinea
    Charles S Mgone
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Trop Med Int Health 8:219-27. 2003
  2. ncbi Subacute sclerosing panencephalitis in two brothers
    S Vieker
    Kinderklinik Gilead, Bielefeld, Germany
    Neuropediatrics 34:326-9. 2003
  3. ncbi Subacute sclerosing panencephalitis
    Ravindra Kumar Garg
    Department of Neurology, Chhatrapati Shahuji Maharaj Medical University, Uttar Pradesh, Lucknow, India
    J Neurol 255:1861-71. 2008
  4. ncbi Subacute sclerosing panencephalitis: an update
    Jose Gutierrez
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Dev Med Child Neurol 52:901-7. 2010
  5. ncbi Molecular mechanisms of measles virus persistence
    Bertus K Rima
    School of Biology and Biochemistry and Centre for Cancer Research and Cell Biology, The Queen s University of Belfast, Belfast BT9 7BL, Northern Ireland, UK
    Virus Res 111:132-47. 2005
  6. ncbi Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized
    William J Bellini
    Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:1686-93. 2005
  7. ncbi Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control
    M B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla CA, USA
    Curr Top Microbiol Immunol 330:31-54. 2009
  8. pmc Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Antimicrob Agents Chemother 48:4631-5. 2004
  9. ncbi Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study
    Generoso G Gascon
    Department of Neuroscience, MBC J 76, King Faisal Specialist Hospital and Research Center, PO Box 40047, Jeddah 21499, Saudi Arabia
    J Child Neurol 18:819-27. 2003
  10. ncbi Antibodies to borna disease virus in subacute sclerosing panencephalitis
    Serdal Gungor
    Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Infect Dis J 24:833-4. 2005

Research Grants

Detail Information

Publications202 found, 100 shown here

  1. ncbi Clinical presentation of subacute sclerosing panencephalitis in Papua New Guinea
    Charles S Mgone
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Trop Med Int Health 8:219-27. 2003
    ..a period of 3 years and 9 months between February 1997 and November 2000 were confirmed to have subacute sclerosing panencephalitis (SSPE)...
  2. ncbi Subacute sclerosing panencephalitis in two brothers
    S Vieker
    Kinderklinik Gilead, Bielefeld, Germany
    Neuropediatrics 34:326-9. 2003
    We report the occurrence of subacute sclerosing panencephalitis (SSPE) in two brothers two years after measles infection...
  3. ncbi Subacute sclerosing panencephalitis
    Ravindra Kumar Garg
    Department of Neurology, Chhatrapati Shahuji Maharaj Medical University, Uttar Pradesh, Lucknow, India
    J Neurol 255:1861-71. 2008
    b>Subacute sclerosing panencephalitis (SSPE) is a subacute encephalopathy of childhood and young adolescence. Infrequently, SSPE can occur in adults and pregnant women. It is caused by an aberrant measles virus, known as the SSPE virus...
  4. ncbi Subacute sclerosing panencephalitis: an update
    Jose Gutierrez
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Dev Med Child Neurol 52:901-7. 2010
    b>Subacute sclerosing panencephalitis (SSPE) is a chronic encephalitis occurring after infection with measles virus...
  5. ncbi Molecular mechanisms of measles virus persistence
    Bertus K Rima
    School of Biology and Biochemistry and Centre for Cancer Research and Cell Biology, The Queen s University of Belfast, Belfast BT9 7BL, Northern Ireland, UK
    Virus Res 111:132-47. 2005
    As measles virus causes subacute sclerosing panencephalitis and measles inclusion body encephalitis due to its ability to establish human persistent infection, without symptoms for the time between the acute infection and the onset of ..
  6. ncbi Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized
    William J Bellini
    Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:1686-93. 2005
    The most severe sequela of measles virus infection is subacute sclerosing panencephalitis (SSPE), a fatal disease of the central nervous system that generally develops 7-10 years after infection...
  7. ncbi Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control
    M B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla CA, USA
    Curr Top Microbiol Immunol 330:31-54. 2009
    b>Subacute sclerosing panencephalitis (SSPE) is a chronic neurodegenerative disease of the central nervous system (CNS) that afflicts eight to 20 individuals per one million of those who become infected with measles virus (MV)...
  8. pmc Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Antimicrob Agents Chemother 48:4631-5. 2004
    ..Five patients with subacute sclerosing panencephalitis (SSPE) were treated with ribavirin by intraventricular administration...
  9. ncbi Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study
    Generoso G Gascon
    Department of Neuroscience, MBC J 76, King Faisal Specialist Hospital and Research Center, PO Box 40047, Jeddah 21499, Saudi Arabia
    J Child Neurol 18:819-27. 2003
    ..Isoprinosine) and intraventricular interferon-alpha2b (Intron A) (group B) in patients with subacute sclerosing panencephalitis (SSPE) was compared...
  10. ncbi Antibodies to borna disease virus in subacute sclerosing panencephalitis
    Serdal Gungor
    Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Infect Dis J 24:833-4. 2005
    Mechanisms causing persistence and reactivation of measles virus in subacute sclerosing panencephalitis (SSPE) are unknown. Borna disease virus (BDV) frequently causes latent or persistent infection in the nervous system...
  11. ncbi Subacute sclerosing panencephalitis findings at MR imaging, diffusion MR imaging, and proton MR spectroscopy
    R Nuri Sener
    Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey
    AJNR Am J Neuroradiol 25:892-4. 2004
    A case of subacute sclerosing panencephalitis in a 2-year-old boy is reported...
  12. pmc Epidemiology of subacute sclerosing panencephalitis (SSPE) in Germany from 2003 to 2009: a risk estimation
    Katharina Schönberger
    Department of Public Health, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany
    PLoS ONE 8:e68909. 2013
    b>Subacute sclerosing panencephalitis (SSPE) is a fatal long-term complication of measles infection...
  13. ncbi Measles virus infection of the CNS: human disease, animal models, and approaches to therapy
    Dajana Reuter
    Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Str 7, Wurzburg, Germany
    Med Microbiol Immunol 199:261-71. 2010
    ..occur early (acute postinfectious measles encephalitis, APME) or after years of viral persistence (subacute sclerosing panencephalitis, SSPE)...
  14. ncbi Evidence that the hypermutated M protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive CNS disease
    J B Patterson
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 291:215-25. 2001
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive degenerative disease of the brain uniformly leading to death...
  15. pmc Characteristics of viruses derived from nude mice with persistent measles virus infection
    Yusaku Abe
    Department of Pediatrics, Fukushima Medical University, Fukusjima, Japan
    J Virol 87:4170-5. 2013
    Measles virus (MV) isolates from patients with subacute sclerosing panencephalitis (SSPE) differ from wild-type MV virologically. However, few animal models have reported viruses with characteristics of the SSPE virus...
  16. ncbi Neurodegenerative mechanisms in subacute sclerosing panencephalitis
    Masaharu Hayashi
    Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
    J Child Neurol 17:725-30. 2002
    b>Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination...
  17. pmc Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies
    Mark P Burgoon
    Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:7245-50. 2005
    ..microdissection was used to isolate individual CD38+ plasma cells from the brain of a patient with subacute sclerosing panencephalitis, and single-cell RT-PCR was used to analyze individual IgG heavy and light chains expressed by each ..
  18. pmc The F gene of the Osaka-2 strain of measles virus derived from a case of subacute sclerosing panencephalitis is a major determinant of neurovirulence
    Minoru Ayata
    Department of Virology, Osaka City University Medical School, and Department of Pediatrics, Izumi Municipal Hospital, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Virol 84:11189-99. 2010
    Measles virus (MV) is the causative agent for acute measles and subacute sclerosing panencephalitis (SSPE)...
  19. pmc Subacute sclerosing panencephalitis in papua new guinean children: the cost of continuing inadequate measles vaccine coverage
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS Negl Trop Dis 5:e932. 2011
    b>subacute sclerosing panencephalitis (SSPE) is a late, rare and usually fatal complication of measles infection...
  20. ncbi Subacute sclerosing panencephalitis with atypical features
    Hamid R Salehi
    Department of Neurology, Comprehensive Epilepsy Management Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pediatr Neurol 33:280-2. 2005
    The incidence of subacute sclerosing panencephalitis may be rising...
  21. ncbi Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis
    William G Ondo
    Baylor College of Medicine, Department of Neurology, Houston, Texas, USA
    Mov Disord 17:154-7. 2002
    We report on a 26-year-old woman with subacute sclerosing panencephalitis (SSPE) who presented with frequent paroxysmal dystonic posturing...
  22. ncbi Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS
    K Aydin
    Department of Neuroradiology, Istanbul Medical School, Istanbul University, Turkey
    Neurology 67:911-3. 2006
    The authors studied 20 patients with subacute sclerosing panencephalitis (SSPE) to investigate the correlations between MRI, magnetic resonance spectroscopy (MRS), and clinical status. MRI findings did not correlate with clinical status...
  23. ncbi Neuroprogressive disease of post-infectious origin: a review of a resurging subacute sclerosing panencephalitis (SSPE)
    P R Dyken
    The USA International SSPE Registry, The Institute of Research in Childhood Neurodegenerative Diseases, Mobile, Alabama 36670 0191, USA
    Ment Retard Dev Disabil Res Rev 7:217-25. 2001
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive, essentially untreatable, disease of the nervous system...
  24. ncbi Unusual manifestation of subacute sclerosing panencephalitis: case with intracranial high-pressure symptoms
    Ozgur Duman
    Department of Pediatric Neurology, Akdeniz University Medical School, Antalya, Turkey
    J Child Neurol 19:552-5. 2004
    b>Subacute sclerosing panencephalitis can show variations in clinical course, and some ophthalmologic abnormalities can be seen as cortical blindness and optic atrophy...
  25. ncbi Subacute sclerosing panencephalitis
    G G Gascon
    Department of Neurology, Brown University, Rhode Island Hospital, Providence, USA
    Semin Pediatr Neurol 3:260-9. 1996
    b>Subacute sclerosing panencephalitis (SSPE), a neurodegenerative disease caused by a persistent "slow virus infection" with a mutated measles virus, is endemic in much of the developing world...
  26. ncbi Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular alpha-interferon
    B Anlar
    Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey
    Neurology 48:526-8. 1997
    We treated 22 patients with subacute sclerosing panencephalitis (SSPE) with intraventricular alpha-interferon (alpha-IFN) and oral inosiplex between 1986 and 1991...
  27. ncbi Optic atrophy and macular degeneration as initial presentations of subacute sclerosing panencephalitis
    Nilufer Berker
    Department of Ophthalmology, Ankara Social Insurance Hospital, Turkey
    Am J Ophthalmol 138:879-81. 2004
    To report a case of subacute sclerosing panencephalitis in which the initial clinical presentations were optic atrophy and macular degeneration.
  28. ncbi Long term survival in subacute sclerosing panencephalitis: an enigma
    L K Prashanth
    Department of Neurology, National Institute of Mental Health and Neurosciences, NIMHANS, Bangalore 560029, Karnataka, India
    Brain Dev 28:447-52. 2006
    b>Subacute sclerosing panencephalitis (SSPE) usually has a progressive stereotypic downhill course and results in premature death. Long-term stabilization or remission is exceptional.
  29. ncbi Alpha-interferon and isoprinosine in adult-onset subacute sclerosing panencephalitis
    Z Gokcil
    Department of Neurology, Gulhane Medical School, Ankara, Turkey
    J Neurol Sci 162:62-4. 1999
    We report eight patients with adult-onset subacute sclerosing panencephalitis (SSPE), of which, four were treated with oral isoprinosine and four with intraventricular alpha-interferon plus oral isoprinosine...
  30. ncbi Combined oral isoprinosine-intraventricular alpha-interferon therapy for subacute sclerosing panencephalitis
    G Gascon
    Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Brain Dev 15:346-55. 1993
    Eighteen patients, 16 boys and 2 girls, aged 5-14 years, with subacute sclerosing panencephalitis (SSPE) were treated with oral isoprinosine (100 mg/kg/day) and intraventricular alpha-interferon 2b (Intron A, Schering Corp...
  31. ncbi MRI follow-up of basal ganglia involvement in subacute sclerosing panencephalitis
    G Akdal
    Department of Neurology, , Izmir, Turkey
    Pediatr Neurol 24:393-5. 2001
    A 12-year-old male with subacute sclerosing panencephalitis is presented. Magnetic resonance imaging revealed basal ganglia involvement without white matter changes for several months...
  32. ncbi Successful treatment of encephalopathy and myoclonus with levetiracetam in a case of subacute sclerosing panencephalitis
    Daniel Becker
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Child Neurol 24:763-7. 2009
    b>Subacute sclerosing panencephalitis is a devastating progressive degenerative disease of the nervous system presumably caused by a persistent measles virus. Patients commonly present with myoclonia or encephalopathy...
  33. ncbi Characterization of measles virus strains causing SSPE: a study of 11 cases
    L Jin
    Enteric, Respiratory, and Neurological Virus Laboratory, Central Public Health Laboratory, London, United Kingdom
    J Neurovirol 8:335-44. 2002
    Eleven subacute sclerosing panencephalitis (SSPE) cases diagnosed in the UK between 1965 and 2000 were investigated...
  34. pmc Measles virus-specific plasma cells are prominent in subacute sclerosing panencephalitis CSF
    G P Owens
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 68:1815-9. 2007
    To demonstrate the specificity of expanded CD138(+) plasma cell clones recovered from the CSF of a patient with subacute sclerosing panencephalitis (SSPE) for measles virus (MV).
  35. ncbi Brainstem involvement in subacute sclerosing panencephalitis
    Pawan Sharma
    Department of Neurology, Chhatrapati Shahuji Maharaj Medical University, Uttar Pradesh, Lucknow, India
    Neurol India 59:273-5. 2011
    The parieto-occipital region of the brain is most frequently and severely affected in subacute sclerosing panencephalitis (SSPE). The basal ganglia, cerebellum and corpus callosum are less commonly involved...
  36. ncbi Subacute sclerosing panencephalitis presenting as acute disseminated encephalomyelitis
    Serdar Comert
    Dr Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey
    Indian J Pediatr 73:1119-21. 2006
    b>Subacute sclerosing panencephalitis (SSPE) is a chronic encephalitis of childhood and young adolescence due to persistent measles virus infection of the central nervous system. In majority of cases onset occurs from 5-15 years of age...
  37. ncbi Epidemiological findings and clinical and magnetic resonance presentations in subacute sclerosing panencephalitis
    H Cece
    Department of Radiology, Harran University School of Medicine, Sanliurfa, Turkey
    J Int Med Res 39:594-602. 2011
    b>Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease...
  38. ncbi PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis
    Yoshito Ishizaki
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Hum Genet 127:411-9. 2010
    Although the exact pathogenesis of subacute sclerosing panencephalitis (SSPE) remains to be determined, our previous data suggested a genetic contribution to the host susceptibility to SSPE...
  39. pmc A role for dual viral hits in causation of subacute sclerosing panencephalitis
    Michael B A Oldstone
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 202:1185-90. 2005
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive fatal neurodegenerative disease associated with persistent infection of the central nervous system (CNS) by measles virus (MV), biased hypermutations of the viral genome ..
  40. ncbi Review of the effect of measles vaccination on the epidemiology of SSPE
    H Campbell
    Immunisation Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    Int J Epidemiol 36:1334-48. 2007
    When measles vaccines were widely introduced in the 1970s, there were concerns that they might cause subacute sclerosing panencephalitis (SSPE): a very rare, late-onset, neurological complication of natural measles infection...
  41. pmc A continuing high incidence of subacute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea
    T Takasu
    Department of Neurology, Nihon University School of Medicine, 30 1 Oyaguchikami machi, Itabashi ku, Tokyo, 173 8610 Japan
    Epidemiol Infect 131:887-98. 2003
    The aims of this descriptive study were to confirm the high incidence of subacute sclerosing panencephalitis (SSPE) previously reported from Papua New Guinea (PNG) and to relate SSPE to previous measles vaccination and measles illness...
  42. ncbi Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis
    Takehiko Inoue
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arch Neurol 59:822-7. 2002
    Although the exact pathogenesis of subacute sclerosing panencephalitis (SSPE) remains to be determined, both viral and host factors seem to be involved.
  43. ncbi Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis
    H Torisu
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurology 62:457-60. 2004
    ..The authors investigated whether the MxA gene contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individuals.
  44. ncbi Familial subacute sclerosing panencephalitis in two siblings
    Ingrid E B Tuxhorn
    Section of Pediatric Epilepsy, Epilepsy Center Bethel, Maraweg 21, 33617 Bielefeld, Germany
    Pediatr Neurol 31:291-4. 2004
    b>Subacute sclerosing panencephalitis is a form of chronic persistent measles encephalitis in childhood which rarely manifests after wild virus infection...
  45. ncbi Subacute sclerosing panencephalitis (SSPE): an insight into the diagnostic errors from a tertiary care university hospital
    L K Prashanth
    Department of Neurology and Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    J Child Neurol 22:683-8. 2007
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive disease caused by wild-type measles virus leading to premature death. Early diagnosis may help in medical interventions and counseling...
  46. ncbi Interleukin (IL)-12, IL-2, interferon-gamma gene polymorphisms in subacute sclerosing panencephalitis patients
    Vuslat Yilmaz
    Department of Physiology, Istanbul Medical Faculty, Istanbul, Turkey
    J Neurovirol 13:410-5. 2007
    Mutated measles virus variants have been claimed as the causing agent for subacute sclerosing panencephalitis (SSPE) developing several years after the recovery from measles infection...
  47. ncbi [Genetic susceptibility to infectious diseases: immunogenetical approaches to mycobacterial infections and subacute sclerosing panencephalitis]
    Koichi Kusuhara
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J UOEH 32:177-94. 2010
    ..have conducted studies on host genetic factors for the development of mycobacterial infections and subacute sclerosing panencephalitis (SSPE) in the past decade...
  48. ncbi Familial subacute sclerosing panencephalitis associated with short latency
    Vinod Sharma
    Department of Paediatrics, Luton and Dunstable Hospital, Lewsey Road, Luton, United Kingdom
    Pediatr Neurol 38:215-7. 2008
    The familial recurrence of subacute sclerosing panencephalitis is rare. The study of such cases and a comparison of intrafamilial with sporadic cases of subacute sclerosing panencephalitis may shed light on important pathogenetic factors...
  49. ncbi Analysis of MxA, IL-4, and IRF-1 genes in Filipino patients with subacute sclerosing panencephalitis
    J R Pipo-Deveza
    Section of Pediatric Neurology, Department of Pediatrics and Neurosciences, University of the Philippines, Philippine General Hospital, Taft Avenue, Manila, Philippines
    Neuropediatrics 37:222-8. 2006
    b>Subacute sclerosing panencephalitis (SSPE) is a chronic and debilitating disease of the central nervous system caused by a latent measles virus infection...
  50. ncbi Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis
    Yoshito Ishizaki
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Neurovirol 14:486-91. 2008
    ..We investigated whether genes encoding these molecules contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individuals...
  51. pmc Subacute sclerosing panencephalitis, a measles complication, in an internationally adopted child
    D J Bonthius
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Emerg Infect Dis 6:377-81. 2000
    ..years of his life in an orphanage in Thailand before adoption by an American couple became ill with subacute sclerosing panencephalitis and died several months later. The boy had most likely contracted wild-type measles in Thailand...
  52. ncbi Quantitation of intrathecal antibodies in cerebrospinal fluid of subacute sclerosing panencephalitis, herpes simplex encephalitis and multiple sclerosis: discrimination between microorganism-driven and polyspecific immune response
    C Jacobi
    Neurochemistry Laboratory, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    J Neuroimmunol 187:139-46. 2007
    ..9%) or subacute sclerosing panencephalitis (mean measles-F(S)=18.8%) compared to the polyspecific immune response against these antigens e.g...
  53. ncbi Two cases of subacute sclerosing panencephalitis associated with brainstem involvement
    Cahide Yilmaz
    Department of Pediatric Neurology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey
    J Trop Pediatr 53:280-3. 2007
    The most commonly involved areas in subacute sclerosing panencephalitis (SSPE) are periventricular and subcortical white matter. The basal ganglia, cerebellum, spinal cord and corpus callosum are less commonly involved...
  54. ncbi MR imaging, diffusion-weighted imaging and MR spectroscopy findings in acute rapidly progressive subacute sclerosing panencephalitis
    Kader Karli Oguz
    Hacettepe University, Faculty of Medicine, Department of Radiology, Ankara, Turkey
    Brain Dev 29:306-11. 2007
    We are presenting two cases with subacute sclerosing panencephalitis of acute and rapid form, which were initially diagnosed as acute viral encephalitis...
  55. pmc Subacute sclerosing panencephalitis
    R K Garg
    Department of Neurology, King George s Medical College, Lucknow, India
    Postgrad Med J 78:63-70. 2002
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of childhood and early adolescence. It is caused by persistent defective measles virus...
  56. ncbi Tissue inflammatory response in subacute sclerosing panencephalitis (SSPE)
    B Anlar
    Department of Pediatric Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    J Child Neurol 16:895-900. 2001
    The pattern of inflammatory infiltration was studied in the frontal brain biopsies of 28 cases with subacute sclerosing panencephalitis (SSPE) by immunohistochemistry. Lymphocytic infiltration and gliosis were common pathologic findings...
  57. ncbi Myoclonus relieved by carbamazepine in subacute sclerosing panencephalitis
    Aytac Yigit
    Ankara University, Faculty of Medicine, Department of Neurology, Ankara, Turkey
    Epileptic Disord 8:77-80. 2006
    A 20-year-old woman with subacute sclerosing panencephalitis, bedridden because of dystonic posturing and very frequent myoclonic involuntary movements, improved dramatically with carbamazepine...
  58. ncbi Nonconvulsive status epilepticus on electroencephalography in a case with subacute sclerosing panencephalitis
    Omer Faruk Aydin
    Department of Pediatric Neurology, Dr Sami Ulus Children s Hospital, Ankara, Turkey
    J Child Neurol 21:256-60. 2006
    b>Subacute sclerosing panencephalitis is a neurodegenerative disease with a poor prognosis. We report a case of a 5 1/2-year-old boy who had emotional lability, cognitive difficulties, and myoclonia after a mild closed head injury...
  59. pmc Wild-type measles virus in brain tissue of children with subacute sclerosing panencephalitis, Argentina
    Paola Roxana Barrero
    Laboratorio de Virologia, Hospital de Niños Dr Ricardo Gutierrez, Gallo 1330 1425, Buenos Aires, Argentina
    Emerg Infect Dis 9:1333-6. 2003
  60. ncbi Fulminant subacute sclerosing panencephalitis:two cases with atypical presentation
    Borivoj D Marjanovic
    Pediatric Clinic, Mother and Child Health Institute, Belgrade, Yugoslavia
    Pediatr Neurol 29:63-5. 2003
    From 1972 to 2002, we diagnosed and treated 22 cases of subacute sclerosing panencephalitis. We report on two pediatric patients with fulminant subacute sclerosing panencephalitis who had atypical clinical manifestations...
  61. pmc The SI strain of measles virus derived from a patient with subacute sclerosing panencephalitis possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity
    Fumio Seki
    Department of Virology 3, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama 208 0011, Tokyo, Japan
    J Virol 85:11871-82. 2011
    b>Subacute sclerosing panencephalitis (SSPE) is a fatal sequela associated with measles and is caused by persistent infection of the brain with measles virus (MV)...
  62. ncbi Subacute sclerosing panencephalitis presenting with hemiparesis in childhood: case report
    Hamit Ozyurek
    Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Child Neurol 18:363-5. 2003
    b>Subacute sclerosing panencephalitis is a chronic and fatal disease of the central nervous system. Most patients present with progressive psychointellectual disturbances...
  63. pmc The matrix proteins of neurovirulent subacute sclerosing panencephalitis virus and its acute measles virus progenitor are functionally different
    A Hirano
    Department of Microbiology, University of Washington School of Medicine, Seattle 98195
    Proc Natl Acad Sci U S A 89:8745-9. 1992
    Persistence of measles virus in the brains of patients with subacute sclerosing panencephalitis (SSPE) is accompanied by changes in the viral matrix (M) protein...
  64. ncbi Twenty-year follow-up of a patient with subacute sclerosing panencephalitis
    T Hashimoto
    Third Department of Medicine Neurology, Shinshu University School of Medicine, Matsumoto, Japan
    Eur Neurol 54:60-2. 2005
  65. ncbi Proton MR spectroscopy in the diagnosis of early-stage subacute sclerosing panencephalitis
    Mehmet Teksam
    Department of Radiology, Baskent University School of Medicine, Ankara, Turkey
    Diagn Interv Radiol 12:61-3. 2006
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive, fatal neurological disorder of childhood and early adolescence...
  66. ncbi [Subacute sclerosing panencephalitis: fulminant form]
    J Grippo
    División of Neurología, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Rev Neurol 36:536-9. 2003
    b>Subacute sclerosing panencephalitis (SSPE) has become less frequent as a consequence of massive anti measles vaccination...
  67. pmc Subacute sclerosing panencephalitis: results of the Canadian Paediatric Surveillance Program and review of the literature
    Craig Campbell
    Section of Pediatric Neurology, Department of Pediatrics, Children s Hospital of Western Ontario, University of Western Ontario, London, Canada
    BMC Pediatr 5:47. 2005
    b>Subacute Sclerosing Panencephalitis (SSPE) is so rare in developed countries with measles immunization programs that national active surveillance is now needed to capture sufficient number of cases for meaningful analysis of data...
  68. ncbi Intravenous gamma-globulin treatment in a patient with subacute sclerosing panencephalitis
    Y K Gürer
    Department of Pediatric Neurology, Dr Sami Ulus Children s Hospital, Altindag, Ankara, Turkey
    Pediatr Neurol 14:72-4. 1996
    A 10-year-old boy with subacute sclerosing panencephalitis was treated with intravenous gamma-globulin and inosiplex and followed for 18 months...
  69. ncbi Changing epidemiological features of subacute sclerosing panencephalitis
    B Anlar
    Hacettepe University Dept of Pediatric Neurology, Ankara, Turkey
    Infection 29:192-5. 2001
    b>Subacute sclerosing panencephalitis (SSPE) is a chronic central nervous (CNS) system infection caused by measles virus...
  70. pmc The epidemiology of subacute sclerosing panencephalitis in England and Wales 1990-2002
    C Miller
    Immunisation Department, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    Arch Dis Child 89:1145-8. 2004
    To assess the impact of measles/mumps/rubella (MMR) vaccine on the epidemiology of subacute sclerosing panencephalitis (SSPE) in England and Wales.
  71. ncbi Combined treatment with subcutaneous interferon-alpha, oral isoprinosine, and lamivudine for subacute sclerosing panencephalitis
    Omer Faruk Aydin
    Department of Pediatric Neurology, Dr Sami Ulus Children s Hospital, Ankara, Turkey
    J Child Neurol 18:104-8. 2003
    We compared patients with subacute sclerosing panencephalitis who received treatment according to our protocol for at least 6 months (19 patients) with the patients who could not receive any treatment (13 patients)...
  72. pmc Adult onset subacute sclerosing panencephalitis: clinical profile of 39 patients from a tertiary care centre
    L K Prashanth
    Department of Neurology, National Institute of Mental Health and Neuro Sciences NIMHANS, Hosur Road, Bangalore 560029, India
    J Neurol Neurosurg Psychiatry 77:630-3. 2006
    Clinical and laboratory characteristics of 39 patients with adult onset subacute sclerosing panencephalitis (SSPE) are described and compared to those of juvenile onset patients regarding preceding measles, age at onset, gender, interval ..
  73. ncbi Trial of intraventricular ribavirin therapy for subacute sclerosing panencephalitis in Japan
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Brain Dev 25:514-7. 2003
    ..Although effectiveness varied among cases, they were all treated safely with intraventricular ribavirin. This study suggests that treatment is safe and well-tolerated...
  74. ncbi Subacute sclerosing panencephalitis in children: prevalence in South China
    Patrick Ip
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Pediatr Neurol 31:46-51. 2004
    This investigation reports the prevalence and clinical profile of subacute sclerosing panencephalitis in two developed cities of southern China...
  75. ncbi Subacute sclerosing panencephalitis in the differential diagnosis of encephalitis
    S Honarmand
    Viral and Rickettsial Disease Laboratory, Division of Communicable Disease Control, California Department of Health Services, 850 Marina Bay Parkway, Richmond, CA 94804, USA
    Neurology 63:1489-93. 2004
    The authors describe five cases of subacute sclerosing panencephalitis (SSPE) identified through the California Encephalitis Project that emphasize the importance of considering SSPE in the differential diagnosis of encephalitis, ..
  76. ncbi Subacute sclerosing panencephalitis in Bulgaria (1978-2002)
    Veneta Bojinova
    Child Neurology Clinic, University Hospital of Neurology and Psychiatry, BG 1113 Sofia, Bulgaria
    Neuroepidemiology 23:254-7. 2004
    The epidemiology of subacute sclerosing panencephalitis (SSPE) has changed substantially since the introduction of measles vaccine...
  77. ncbi Intraventricular interferon and oral inosiplex in the treatment of subacute sclerosing panencephalitis
    K Yalaz
    Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey
    Neurology 42:488-91. 1992
    We treated 22 patients with subacute sclerosing panencephalitis (SSPE) with intraventricular alpha-interferon (IFN) and inosiplex PO and followed them for 2 to 54 months. Three deaths occurred...
  78. ncbi Subacute sclerosing panencephalitis with atypical onset: clinical, computed tomographic, and magnetic resonance imaging correlations
    P Dimova
    Clinic of Child Neurology, Medical Universityi, Sofia, Bulgaria
    J Child Neurol 15:258-60. 2000
    Clinical, computed tomographic (CT), and magnetic resonance imaging (MRI) correlations of subacute sclerosing panencephalitis with an atypical onset are presented in three children...
  79. ncbi Beta-interferon plus inosiplex in the treatment of subacute sclerosing panencephalitis
    B Anlar
    Hacettepe University Department of Pediatric Neurology, Ankara, Turkey
    J Child Neurol 13:557-9. 1998
    We treated seven patients with subacute sclerosing panencephalitis with beta-interferon and oral inosiplex for 2 to 15 months. Stabilization or improvement was observed in three patients...
  80. ncbi Elevated levels of anti-CD9 antibodies in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis
    Toko Shimizu
    Institute of Life Science and Department of Pediatrics, School of Medicine, Kurume University, Fukuoka, Japan
    J Infect Dis 185:1346-50. 2002
    b>Subacute sclerosing panencephalitis (SSPE) is a slowly progressive and highly lethal disease of the central nervous system...
  81. ncbi Clinical effects of MND-19 (Inosiplex) on subacute sclerosing panencephalitis--a multi-institutional collaborative study--The Inosiplex-SSPE Research Committee
    Y Fukuyama
    Department of Pediatrics, Tokyo Women s Medical College, Japan
    Brain Dev 9:270-82. 1987
    A total of 151 cases of subacute sclerosing panencephalitis (SSPE), comprising 89 cases treated with MND-19 (Inosiplex) and 62 untreated cases, were retrospectively investigated as to background characteristics, survival rate and ..
  82. ncbi Molecular analysis of measles virus genome derived from SSPE and acute measles patients in Papua, New Guinea
    Kenji Miki
    Department of Neurology, Nihon University School of Medicine, Tokyo, Japan
    J Med Virol 68:105-12. 2002
    A very high annual incidence of 56 per million population below the age of 20 years for subacute sclerosing panencephalitis (SSPE) has been reported from Papua New Guinea (PNG)...
  83. ncbi An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis
    Stephen McQuaid
    Neuropathology Laboratory, Royal Victoria Hospital, Queen s University Belfast, Northern Ireland
    Lab Invest 82:403-9. 2002
    ..in a range of normal peripheral tissues (known to be infected by MV) as well as in normal and subacute sclerosing panencephalitis (SSPE) brain...
  84. ncbi Subacute sclerosing panencephalitis: clinical and magnetic resonance imaging evaluation of 36 patients
    Aylin Ozturk
    Department of Neurology, Medicine School of Istanbul, Istanbul University, Capa Istanbul, Turkey
    J Child Neurol 17:25-9. 2002
    We studied 36 patients (24 males, 12 females), all of whom had definite subacute sclerosing panencephalitis with typical periodic complexes in their electroencephalograms and increased titers of measles antibody in serum and ..
  85. ncbi Early- and late-state subacute sclerosing panencephalitis: chemical shift imaging and single-voxel MR spectroscopy
    Alpay Alkan
    Department of Radiology, Inonu University School of Medicine, Malatya, Turkey
    AJNR Am J Neuroradiol 24:501-6. 2003
    b>Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease...
  86. ncbi [A case of subacute sclerosing panencephalitis developing 8 years after immunosuppressive treatment for acute lymphocytic leukemia]
    H Fukuya
    Department of Pediatrics, School of Medicine, Fukuoka University
    No To Hattatsu 24:60-4. 1992
    A 13-year-old girl developed subacute sclerosing panencephalitis (SSPE) with atypical absence attacks as an initial symptom...
  87. ncbi [Comparison of the results of the treatment of patients with SSPE using various immunomodulating preparations]
    W Sobczyk
    I Kliniki Neurologicznej Instytutu Psychiatrii i Neurologii, Warszawie
    Neurol Neurochir Pol 25:626-33. 1991
    ..The final evaluation of the results requires further observations of these patients...
  88. ncbi [Adult-onset subacute sclerosing panencephalitis: clinicopathological findings]
    J Gonzalez de la Aleja
    Servicio de Neurologia, Hospital Universitario 12 de Octubre, 28045 Madrid, Espana
    Rev Neurol 40:729-32. 2005
    b>Subacute sclerosing panencephalitis is a disease affecting the central nervous system that is produced by persistent infection by a defective measles virus...
  89. ncbi [Subacute sclerosing panencephalitis: combined treatment with interferon alpha and intraventricular ribavirin]
    M del Toro-Riera
    Servicio de Neurología Pediátrica, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Rev Neurol 42:277-81. 2006
    b>Subacute sclerosing panencephalitis (SSPE) is a chronic neurodegenerative disease secondary to an infection of the central nervous system by the measles virus, with no effective treatment...
  90. ncbi Changing trend of SSPE over a period of ten years
    B Mishra
    Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh
    Indian J Public Health 49:235-7. 2005
    ..05). The high incidence of SSPE in our country could be due to improper vaccine coverage, poor cold chain maintenance or circulation of atypical measles virus strain...
  91. ncbi Macular retinitis as a first sign of subacute sclerosing panencephalitis: the importance of early diagnosis
    A Serdaroglu
    Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey
    Ocul Immunol Inflamm 13:405-10. 2005
    b>Subacute sclerosing panencephalitis (SSPE) is a subacute inflammatory and neurodegenerative encephalitis related to the measles (rubeola) virus and usually affecting children and young adults...
  92. ncbi [Epidemiology of subacute sclerosing panencephalitis in Okinawa, Japan, 1970-1996]
    K Hirayasu
    Okinawa Seishi Ryogoen
    No To Hattatsu 31:27-31. 1999
    In Okinawa, there were ten cases (7 male and 3 female) of subacute sclerosing panencephalitis (SSPE) from 1970 to 1996. All cases had a history of measles and none had received measles vaccination. The incidence of SSPE in Okinawa was 0...
  93. ncbi Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis
    K Kusuhara
    Dept of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Infect Dis 181:1447-9. 2000
    Measles virus (MV) binding sites of the CD46 gene were sequenced in patients with subacute sclerosing panencephalitis (SSPE) and in controls...
  94. ncbi Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection
    Enver Simsek
    Department of Pediatrics, Abant Izzet Baysal University, Duzce Faculty of Medicine, Duzce, Turkey
    Turk J Pediatr 47:58-62. 2005
    ..Electroencephalography (EEG) revealed periodic high-amplitude slow waves. Diagnosis of subacute sclerosing panencephalitis (SSPE) was based upon clinical presentation, a characteristic EEG, and abnormal CSF studies...
  95. ncbi A vaccine-preventable infectious disease kills half a million children annually
    Samuel L Katz
    J Infect Dis 192:1679-80. 2005
  96. ncbi Role of CSF serology in follow-up of subacute sclerosing panencephalitis patients on treatment
    E Gupta
    Depatment of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Indian J Med Microbiol 24:131-2. 2006
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory disease of the central nervous system with poor prognosis and high mortality...
  97. ncbi 18F-FDG PET in a 10-year-old female patient with subacute sclerosing panencephalitis
    Antonia Dimitrakopoulou-Strauss
    Medical PET Group Biological Imaging E0601, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 33:1100-1. 2006
  98. ncbi Indication of peripheral nerve hyperexcitability in adult-onset subacute sclerosing panencephalitis (SSPE)
    Annabel Schreurs
    Department of Neurology, University Hospital Gasthuisberg, Leuven, Belgium
    Neurol Sci 29:121-4. 2008
    b>Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection of immune-resistant measles virus...
  99. ncbi Patients with acute, fulminant form of SSPE
    M Ozlem Herguner
    Department of Pediatric Neurology, Cukurova University Faculty of Medicine, Adana, Turkey
    Turk J Pediatr 49:422-5. 2007
    b>Subacute sclerosing panencephalitis (SSPE) usually begins insidiously and follows a subacute course with relentless but slow progression to death. In recent years, however, patients with acute or fulminant course were reported...
  100. ncbi Atypical subacute sclerosing panencephalitis: case report
    Marcelo Maroco Cruzeiro
    Neurology Service, Department of Internal Medicine, University Hospital, Federal University of Juiz de Fora, Avenida Rio Branco 2370 802, Juiz de Fora, MG, Brazil
    Arq Neuropsiquiatr 65:1030-3. 2007
    b>Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory disorder of the central nervous system with both poor prognosis and high mortality...
  101. ncbi First detection of measles genotype D7 from India
    Sunil R Vaidya
    Measles Group, National Institute of Virology, 20 A, Dr Ambedkar Road, PO Box 11, Pune 411001, India
    Virus Genes 36:31-4. 2008
    ..Measles genotype D7 was detected from two classical measles cases (Chennai and Pune) and in a fulminant SSPE case (Bangalore). This is the first detection of measles genotype D7 from India...

Research Grants20

  1. Mechanisms of cytokine-mediated viral clearance from neurons
    LAUREN ALENE O apos DONNELL; Fiscal Year: 2010
    ..in the central nervous system (CMS) is associated with neuropathological disorders, such as subacute sclerosing panencephalitis (SSPE), in which the immune system fails to control MV replication in the brain...
  2. Development of therapeutic fusion inhibitor peptides for Measles encephalitis
    Matteo Porotto; Fiscal Year: 2012
    ..the case of acute encephalomyelitis, or years after infection, as a result of viral persistence in subacute sclerosing panencephalitis. The third form of MV-induced CNS disease, progressive infectious encephalitis, occurs 1 to 6 ..
  3. STUDY OF POSSIBLE CAUSES OF PAGET'S DISEASE OF BONE
    BARBARA MILLS; Fiscal Year: 1991
    ..Paget's disease of bone is similar to a slow virus infection of the central nervous system such as subacute sclerosing panencephalitis caused by a mutant measles virus of the Paramyxoviridae family...
  4. ANTIBODY-MODULATED DEMYELINATION
    Stanley Perlman; Fiscal Year: 1993
    Such diseases of the human CNS as multiple sclerosis, subacute sclerosing panencephalitis and the acquired immunodeficiency syndrome probably involve viral latency or persistence and reactivation...
  5. OLIGODENDROGLIAL CELL ANTIGEN(S) IN MULTIPLE SCLEROSIS
    GEORGE ELLISON; Fiscal Year: 1980
    ..S. sera to those isolated with sera from patients with other demyelinating diseases such as subacute sclerosing panencephalitis and acute disseminated encephalomyelitis will be investigated.
  6. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  7. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2008
    ..abstract_text> ..
  8. Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact
    Diane Griffin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLES
    Diane Griffin; Fiscal Year: 2001
    ....
  10. 2007 Viruses & Cells Gordon Conference
    Diane Griffin; Fiscal Year: 2007
    ..abstract_text> ..
  11. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  12. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  13. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  14. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  15. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  16. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  17. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  18. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  19. NEUROTERATOGENIC MECHANISM OF LCM VIRUS INFECTION
    Daniel Bonthius; Fiscal Year: 2005
    ..The importance of a-DG in influencing the tropism and infectivity of LCMV will be examined by blocking alpha-DG with an antibody prior to exposure of brain slices to LCMV. ..
  20. Viral vector-based RNAi therapy for Alexander Disease
    Daniel Bonthius; Fiscal Year: 2008
    ..The disease is due to an abnormal gene. This research aims to develop a form of gene therapy to prevent and reverse the brain dysfunction of Alexander Disease. [unreadable] [unreadable] [unreadable]..