lymphocytic choriomeningitis

Summary

Summary: A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Top Publications

  1. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
  2. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
  3. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
  4. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
  5. ncbi IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    Anja Fröhlich
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
    Science 324:1576-80. 2009
  6. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009
  7. ncbi Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
  8. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
  9. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
  10. pmc Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    Hyun Tak Jin
    Department of Microbiology and Immunology, Emory University School of Medicine, Emory Vaccine Center, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:14733-8. 2010

Detail Information

Publications301 found, 100 shown here

  1. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  2. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..expressed in functionally impaired virus-specific CD8 T cells present in mice chronically infected with lymphocytic choriomeningitis virus (LCMV), and compared these with the gene profile of functional memory CD8 T cells...
  3. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  4. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
    ..Using different strains of lymphocytic choriomeningitis virus (LCMV), we compared responses to the same CD8 T-cell epitopes during acute or chronic infection...
  5. ncbi IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    Anja Fröhlich
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
    Science 324:1576-80. 2009
    ..is critical for the long-term maintenance and functionality of CD8+ T cells and the control of chronic lymphocytic choriomeningitis virus infection in mice...
  6. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009
    ..IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection...
  7. ncbi Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  8. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
    ..Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection...
  9. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  10. pmc Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    Hyun Tak Jin
    Department of Microbiology and Immunology, Emory University School of Medicine, Emory Vaccine Center, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:14733-8. 2010
    ..In this study, we document coregulation of CD8 T cell exhaustion by Tim-3 and PD-1 during chronic lymphocytic choriomeningitis virus infection...
  11. pmc Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
    M F van den Broek
    Institute of Experimental Immunology, University of Zurich, Switzerland
    J Virol 69:4792-6. 1995
    ..an additive phenotype with respect to antiviral defense and exhibited an increased susceptibility to lymphocytic choriomeningitis virus (LCMV) and notably vaccinia virus infection...
  12. pmc Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S Euclid, St Louis, MO 63110, USA
    Cell Host Microbe 11:631-42. 2012
    ..Using acute and chronic lymphocytic choriomeningitis virus (LCMV) infection models, we determined that pDCs transiently produce IFN-I that minimally impacts ..
  13. ncbi IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Cell 144:601-13. 2011
    ..The IL-7-mediated effects were dependent on endogenous IL-6. These attributes of IL-7 have profound implications for its use as a therapeutic in the treatment of chronic viral diseases...
  14. pmc Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
    Laura M Fahey
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 208:987-99. 2011
    ..Importantly, this sustained CD4 T cell functionality is critical to maintain immunity and ultimately aid in the control of persistent viral infection...
  15. ncbi Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections
    Fei Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:5936-40. 2005
    ..This technique will be useful when evaluating in vivo immune cell activity in many situations, including a variety of noninfectious (e.g., autoimmune) diseases...
  16. pmc Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties
    Rachel L Rutishauser
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 31:296-308. 2009
    ..repressor Blimp-1 enhanced the formation of terminally differentiated CD8(+) T cells during lymphocytic choriomeningitis virus (LCMV) infection, and Blimp-1 deficiency promoted the acquisition of memory cell properties by ..
  17. pmc Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo
    Megan M McCausland
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol Methods 147:167-76. 2008
    ..We have developed a QPCR assay to accurately quantify lymphocytic choriomeningitis virus (LCMV) in infected mice. We first validated this assay using plasmid DNA and LCMV viral stocks...
  18. ncbi Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
    ..CD8(+) T cell-dependent immunopathological hepatitis in mice infected with the noncytopathic lymphocytic choriomeningitis virus...
  19. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
    ..Here we document self-association (homotypic interaction) of the NP of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), as well as those of the hemorrhagic fever (HF) arenaviruses Lassa virus (LASV) and ..
  20. ncbi Ablation of CD8 and CD4 T cell responses by high viral loads
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294 2170, USA
    J Immunol 170:477-86. 2003
    ..impact of sustained viral loads on anti-viral T cell responses we compared responses that cleared acute lymphocytic choriomeningitis virus infection with those that were elicited but could not resolve chronic infection...
  21. ncbi CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion
    Peter Aichele
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    J Immunol 176:4525-9. 2006
    ..T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR...
  22. pmc Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens
    George A Punkosdy
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:3677-82. 2011
    ..Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of Foxp3(+) Treg that is dependent on retroviral superantigen (sag) ..
  23. ncbi Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Nature 369:31-7. 1994
    ..The mice fail to clear lymphocytic choriomeningitis virus and they eliminate fibrosarcoma tumour cells with reduced efficiency...
  24. pmc Hemorrhagic fever occurs after intravenous, but not after intragastric, inoculation of rhesus macaques with lymphocytic choriomeningitis virus
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland, Biotech Center, Baltimore, Maryland 21201, USA
    J Med Virol 67:171-86. 2002
    ..We describe infection of rhesus macaques with the prototype arenavirus, lymphocytic choriomeningitis virus (LCMV), using the WE strain that has been known to cause both encephalopathy and multifocal ..
  25. pmc Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
    A Gallimore
    Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 187:1647-57. 1998
    Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I-restricted cytotoxic T cells (CTLs), which normally resolve the infection...
  26. ncbi On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection
    Kirsten Richter
    Institute of Microbiology, Department of Biology, Wolfgang Pauli Strasse 10, HCI G401, ETH Zurich, 8093 Zurich, Switzerland
    Int Immunol 22:13-23. 2010
    ..Exhaustion of lymphocytic choriomeningitis virus (LCMV)-specific CD8 T cells was shown to be partially regulated by the inhibitory receptor ..
  27. pmc Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
    Sara Wojciechowski
    Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Exp Med 204:1665-75. 2007
    ..In contrast, Bim(+/-)Bcl-2(-/-) mice generated relatively normal numbers of memory T cells after lymphocytic choriomeningitis virus infection...
  28. pmc A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge
    Devon J Shedlock
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vaccine 29:6755-62. 2011
    ..We developed a highly optimized plasmid DNA vaccine that expresses the lymphocytic choriomeningitis virus (LCMV) nucleocapsid protein (NP) and evaluated it using the LCMV challenge model, a gold standard ..
  29. pmc Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice
    Helge Frebel
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    J Exp Med 209:2485-99. 2012
    ..Yet previous studies reported that PD-L1-deficient mice develop fatal pathology during early systemic lymphocytic choriomeningitis virus (LCMV) infection, suggesting a host protective role of T cell down-regulation...
  30. ncbi Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice
    Marcel Kremer
    Division of Immunology, Department of Biology, Constance University, Konstanz, Germany
    J Immunol 185:5549-60. 2010
    ..We analyzed the immunoproteasome expression in the brain after an infection with lymphocytic choriomeningitis virus (LCMV) and could show that LCMV-infection of mice leads to the transcriptional induction of ..
  31. ncbi Cutting edge: MHC class II-restricted killing in vivo during viral infection
    Evan R Jellison
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:614-8. 2005
    ..In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B ..
  32. ncbi 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
    J T Tan
    The Carlos and Marguerite Mason Transplantation Biology Research Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 163:4859-68. 1999
    ..for the development of primary immune responses, 4-1BBL-deficient (4-1BBL-/-) mice were infected with lymphocytic choriomeningitis virus (LCMV)...
  33. ncbi Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
    Marc Pellegrini
    The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
    Nat Med 15:528-36. 2009
    ..The ability of adjuvant IL-7 to antagonize inhibitory networks at the cellular and molecular level has major implications for immunotherapy in the treatment of tumors...
  34. pmc Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 186:3836-40. 2011
    ..These data suggest that regular booster immunizations may be required to sustain protective vaccine-induced Plasmodium-specific memory CD8 T cells in the face of attrition caused by unrelated infections...
  35. ncbi Lymphocytic choriomeningitis infection of the central nervous system
    Silvia S Kang
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Front Biosci 13:4529-43. 2008
    ..b>Lymphocytic choriomeningitis virus (LCMV) is a powerful model system to explore these potential outcomes of CNS infection due to the ..
  36. pmc Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
    V C Asensio
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 71:7832-40. 1997
    ..In the present study, we examined the expression of multiple chemokine genes during the course of lymphocytic choriomeningitis (LCM) in mice...
  37. pmc Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1
    Anju Singh
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Cell Biol 30:5145-59. 2010
    ..These findings provide critical insights into the cell cycle regulation of CD8 T-cell homeostasis and suggest that modulation of p27(Kip1) could bolster vaccine-induced T-cell memory and protective immunity...
  38. ncbi Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 173:3925-34. 2004
    ..In C57BL/6 mice, the acute cytotoxic T cell response against lymphocytic choriomeningitis virus is directed against immunodominant epitopes derived from the glycoprotein (gp33-41) and the ..
  39. pmc Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection
    Joseph N Blattman
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 83:4386-94. 2009
    ..Here, we tracked the fate of virus-specific CD8 T cells in lymphocytic choriomeningitis virus (LCMV)-infected mice during viral clearance, the persistence of wild-type virus, or the selection ..
  40. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  41. pmc Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infection
    M Suresh
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 79:202-13. 2005
    ..of tumor necrosis factor receptors (TNFRs) I (p55R) and II (p75R) in regulating CD8 T-cell responses to lymphocytic choriomeningitis virus (LCMV) with wild-type, p55R-deficient (p55(-/-)), p75R-deficient (p75(-/-)), and p55R- and p75R-..
  42. pmc Resolution of a chronic viral infection after interleukin-10 receptor blockade
    Mette Ejrnaes
    Immune Regulation Lab DI3, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 203:2461-72. 2006
    ..this paper, we report that IL-10 production is drastically increased in mice persistently infected with lymphocytic choriomeningitis virus...
  43. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin beta3...
  44. ncbi Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination
    Alexander K Nussbaum
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 175:1153-60. 2005
    ..In this study we investigated the CD8(+) T cell responses to lymphocytic choriomeningitis virus infection and DNA immunization in wild-type mice and in mice lacking the immunoproteasome ..
  45. pmc IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection
    Iwana Schmitz
    Molecular Biomedicine, Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 9:e1003362. 2013
    ....
  46. pmc Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection
    Shenghua Zhou
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:11254-65. 2012
    ..the type I IFN signaling pathway, is essential for the type I IFN response to many viruses, including lymphocytic choriomeningitis virus (LCMV)...
  47. pmc Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult
    Daniel J Bonthius
    Department of Pediatrics, Division of Child Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
    Semin Pediatr Neurol 19:89-95. 2012
    b>Lymphocytic choriomeningitis virus (LCMV) is an important cause of neurologic disease in humans. Carried and secreted principally by wild mice, LCMV covers a large geographic range and infects great numbers of people...
  48. pmc Infected CD8α- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection
    Cherie T Ng
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:14116-21. 2012
    ..Our findings further illuminate the contribution of DCs to the production of IL-10 and to viral persistence...
  49. ncbi Reversal of chronic to resolved infection by IL-10 blockade is LCMV strain dependent
    Kirsten Richter
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 43:649-54. 2013
    ..The immune-regulatory cytokine IL-10 promotes chronicity of infection with lymphocytic choriomeningitis virus (LCMV) Clone 13, as absence of IL-10 or blocking of IL-10R during early LCMV Clone 13 infection ..
  50. pmc Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity
    Brian A Norris
    Vaccine Research Center, Emory University, Atlanta, GA 30329, USA
    Immunity 38:309-21. 2013
    ..Here we report that infection with acute Armstrong (ARM) or chronic Clone 13 (C13) strains of lymphocytic choriomeningitis virus (LCMV) led to two distinct phases of innate immune response...
  51. ncbi Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo
    Jason M Grayson
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 169:3760-70. 2002
    ..These findings have implications for designing prime/boost vaccine strategies and also for optimizing immunotherapeutic regimens for treatment of chronic infections...
  52. ncbi Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:4204-14. 2004
    ..In this study, we have used the well-defined system of lymphocytic choriomeningitis virus (LCMV) infection of mice to determine quantitative and qualitative changes in virus-specific CD8 ..
  53. ncbi Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity
    Andreas Bergthaler
    Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    J Gen Virol 88:592-603. 2007
    ..Here we exploited newly developed reverse-genetic techniques with Lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, to address specifically the contribution of the viral ..
  54. ncbi Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
    Joseph N Blattman
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Med 9:540-7. 2003
    ..effects of IL-2 therapy during the expansion, contraction and memory phases of the T-cell response in lymphocytic choriomeningitis virus (LCMV)-infected mice...
  55. pmc A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection
    Alison Crawford
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002098. 2011
    ..Our results demonstrate an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection...
  56. pmc Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection
    Maya F Kotturi
    Pfizer Inc, Vaccine Research West, 10777 Science Center Drive, San Diego, CA 92121, USA
    J Virol 85:11770-80. 2011
    Although cellular immunity to acute lymphocytic choriomeningitis virus (LCMV) infection has been well characterized in experimental studies in mice, the T cell response to this virus in humans is incompletely understood...
  57. pmc Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat
    Daniel J Bonthius
    Department of Pediatrics, Neurology, and Anatomy at the Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 3:e149. 2007
    ..The animal model for congenital lymphocytic choriomeningitis virus (LCMV) infection, however, does not suffer from this limitation...
  58. ncbi T cells in the central nervous system: the delicate balance between viral clearance and disease
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Infect Dis 186:S145-51. 2002
    ..The lymphocytic choriomeningitis virus model offers a unique system in which to evaluate the contrasting roles of specific T cells in ..
  59. ncbi Type I IFN substitutes for T cell help during viral infections
    Melanie Wiesel
    Institute for Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 186:754-63. 2011
    ..In this study, we compared CD8(+) T cell responses elicited by lymphocytic choriomeningitis virus infection, as prototype of a T cell help independent infection, with T cell help dependent CD8(+) ..
  60. pmc Role of lymphotoxin alpha in T-cell responses during an acute viral infection
    M Suresh
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 76:3943-51. 2002
    ..between wild type (+/+) and LTalpha-deficient (LTalpha(-/-)) mice during an acute infection with lymphocytic choriomeningitis virus (LCMV)...
  61. pmc Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation
    Koichi Araki
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 207:2355-67. 2010
    Recently, several cases of fatal lymphocytic choriomeningitis virus (LCMV) infection occurred in transplant recipients being treated with the immunosuppressive calcineurin inhibitor FK506...
  62. ncbi Circulating natural killer and gammadelta T cells decrease soon after infection of rhesus macaques with lymphocytic choriomeningitis virus
    Juan D Rodas
    Grupo de Investigaciones en Ciencias Veterinarias Centauro, Facultad de Ciencias Agrarias, Universidad de Antioquia, Medellin, Colombia
    Mem Inst Oswaldo Cruz 104:583-91. 2009
    Rhesus macaques infected with the WE strain of lymphocytic choriomeningitis virus (LCMV-WE) serve as a model for human infection with Lassa fever virus...
  63. pmc Mouse-to-human transmission of variant lymphocytic choriomeningitis virus
    Sébastien Emonet
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:472-5. 2007
    A case of lymphocytic choriomeningitis virus (LCMV) infection led to investigation of the reservoir. LCMV was detected in mice trapped at the patient's home, and 12 isolates were recovered...
  64. pmc Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection
    Miriam Rode
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Virol 78:12395-405. 2004
    ..of mice that lack Fas as well as granzyme A (gzmA) and gzmB (FasxgzmAxB(-/-)) to infection with lymphocytic choriomeningitis virus (LCMV)...
  65. pmc Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
    Charlly Kao
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:663-71. 2011
    ..Persistent antigenic stimulation caused downregulation of T-bet, which resulted in more severe exhaustion of CD8(+) T cells. Our observations suggest therapeutic opportunities involving higher T-bet expression during chronic infection...
  66. ncbi Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein
    Maria P Rodriguez-Carreno
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 335:87-98. 2005
    ..can induce CD8(+) T cell responses in mice and can protect against challenge with two arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV)...
  67. pmc Recruitment times, proliferation, and apoptosis rates during the CD8(+) T-cell response to lymphocytic choriomeningitis virus
    R J De Boer
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Virol 75:10663-9. 2001
    The specific CD8(+) T-cell response during acute lymphocytic choriomeningitis virus (LCMV) infection of mice is characterized by a rapid proliferation phase, followed by a rapid death phase and long-term memory...
  68. ncbi Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells
    Dorian B McGavern
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 173:4779-90. 2004
    ..Using lymphocytic choriomeningitis virus (LCMV) as a stimulus for T cell recruitment into the CNS, we demonstrate that bystander CD8+ T ..
  69. pmc Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion
    Shawn D Blackburn
    Department of Medical Oncology, Dana Farber Cancer Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 84:2078-89. 2010
    ..These observations have implications for human chronic infections and for therapeutic interventions based on blockade of the PD-1 pathway...
  70. ncbi Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection
    Yinling Lin
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Eur J Immunol 33:2736-43. 2003
    ..Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b(+)CD8(+) and CD11c(+)CD8(+) T cells ..
  71. ncbi In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody
    P Seiler
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
    J Immunol 162:4536-41. 1999
    ..viral Ag, we crossed transgenic mice expressing the mu heavy and the kappa light chain of the lymphocytic choriomeningitis virus (LCMV)-neutralizing mAb KL25 (HL25-transgenic mice) with persistently infected LCMV carrier mice...
  72. ncbi Vaccination against lymphocytic choriomeningitis virus infection in MHC class II-deficient mice
    Peter Johannes Holst
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen DK 2200, Denmark
    J Immunol 186:3997-4007. 2011
    ..response could be elicited in MHC class II-deficient mice by vaccination with adenovirus encoding lymphocytic choriomeningitis virus (LCMV) glycoprotein tethered to MHC class II-associated invariant chain...
  73. ncbi Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses
    S O Andreasen
    Institute of Medical Microbiology, University of Copenhagen, Copenhagen, Denmark
    J Immunol 164:3689-97. 2000
    ..b>Lymphocytic choriomeningitis virus (LCMV) is a natural mouse pathogen that replicates widely and extensively, whereas vesicular ..
  74. pmc Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
    J Neuroimmunol 194:70-82. 2008
    ..In the present study, we demonstrated that central nervous system (CNS) glial cells are activated by Lymphocytic Choriomeningitis Virus (LCMV) in a TLR2-MyD88/Mal-dependent manner...
  75. pmc Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus
    M Djavani
    Institute of Human Virology, University of Maryland Biotechnology Center, Baltimore 21201, USA
    J Hum Virol 4:103-8. 2001
    ..Mice were challenged intracranially with a lethal dose of the related arenavirus, lymphocytic choriomeningitis virus (LCMV), as a measure of the vaccine's ability to elicit cross-protection...
  76. ncbi Lymphocytic choriomeningitis virus--an old enemy up to new tricks
    C J Peters
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, USA
    N Engl J Med 354:2208-11. 2006
  77. ncbi Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection
    P Seiler
    Department of Pathology, University Hospital Zurich, Switzerland
    Eur J Immunol 27:2626-33. 1997
    ..MZM- and MM-depleted mice were not able to control an infection with lymphocytic choriomeningitis virus (LCMV)...
  78. pmc Spatial and temporal dynamics of lymphocytic choriomeningitis virus in wild rodents, northern Italy
    Valentina Tagliapietra
    Edmund Mach Foundation Istituto Agrario di San Michele all Adige, San Michele all Adige, Italy
    Emerg Infect Dis 15:1019-25. 2009
    We determined the prevalence of infection with lymphocytic choriomeningitis virus (LCMV) among small mammals in northern Italy and analyzed long-term dynamics of LCMV in a rodent population in the province of Trento...
  79. pmc Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels
    Kathryn J Mackerness
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:3643-51. 2010
    ..We show that virus-specific CD8 T cells clearly respond during the early stages of chronic lymphocytic choriomeningitis virus infection, and that this early T cell response is more pronounced than that initially observed in ..
  80. ncbi Public, private and non-specific antibodies induced by non-cytopathic viral infections
    Mike Recher
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Curr Opin Microbiol 7:426-33. 2004
    b>Lymphocytic choriomeningitis virus (LCMV) represents a useful experimental model of murine infection with a non-cytopathic virus, bearing resemblance to HIV and hepatitis C virus (HCV) infections in humans...
  81. pmc Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants
    A Ciurea
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 193:297-305. 2001
    ..that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T cell responses are low or absent...
  82. pmc A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection
    Haina Shin
    Immunology Program and Wistar Vaccine Center, The Wistar Institute, Philadelphia, PA 19104, USA
    Immunity 31:309-20. 2009
    ..Thus, we identify Blimp-1 as a transcriptional regulator of CD8(+) T cell exhaustion during chronic viral infection and propose that Blimp-1 acts as a transcriptional rheostat balancing effector function and T cell exhaustion...
  83. pmc Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells
    R Ou
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Virol 75:8407-23. 2001
    Under conditions of high antigenic load during infection with invasive lymphocytic choriomeningitis virus (LCMV) strains, virus can persist by selective clonal exhaustion of antigen-specific CD8(+) T cells...
  84. pmc Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought
    David Masopust
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 81:2002-11. 2007
    ..a more complete accounting of the CD8 T-cell response generated upon infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV)...
  85. ncbi Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice
    Lian Ni Lee
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
    J Immunol 182:7178-89. 2009
    ..1 IFN production during virus persistence, we analyzed type 1 IFN production during acute and chronic lymphocytic choriomeningitis virus (LCMV) infection...
  86. pmc PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 120:2508-15. 2010
    ..mice to examine the effects of PD-L1 deficiency in hematopoietic or nonhematopoietic cells during lymphocytic choriomeningitis virus clone 13 (LCMV CL-13) infection...
  87. pmc Pet rodents and fatal lymphocytic choriomeningitis in transplant patients
    Brian R Amman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 13:719-25. 2007
    In April 2005, 4 transplant recipients became ill after receiving organs infected with lymphocytic choriomeningitis virus (LCMV); 3 subsequently died. All organs came from a donor who had been exposed to a hamster infected with LCMV...
  88. pmc MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection
    Adeeb H Rahman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia PA 19104, USA
    J Immunol 181:3804-10. 2008
    During acute lymphocytic choriomeningitis virus (LCMV) infection, CD8 T cells rapidly expand and differentiate into effectors that are required for viral clearance...
  89. ncbi Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection
    A Oxenius
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
    Immunity 9:449-57. 1998
    ..The functional status of CD4+ T cells during establishment of persistent infection with the noncytopathic lymphocytic choriomeningitis virus was assessed and compared to that of cytotoxic CD8+ T cells...
  90. ncbi Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 185:2182-90. 2010
    ..and functional qualities of these cells with memory T cells generated after systemic infection with lymphocytic choriomeningitis virus (LCMV)...
  91. ncbi Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo
    Melanie Wiesel
    Institute for Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 42:320-9. 2012
    ..We found that under priming conditions dominated by type-I IFN, as observed in lymphocytic choriomeningitis virus (LCMV) infection, type-I IFN signaling directly impacted the regulation of T-bet and thus the ..
  92. ncbi Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3
    Jeanette Erbo Christensen
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci 24:4849-58. 2004
    ..effector T-cells within the brain, CXCR3-deficient mice were infected intracerebrally with lymphocytic choriomeningitis virus (LCMV)...
  93. pmc Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection
    Ella R Hinson
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 184:5723-31. 2010
    ..In this study, we analyzed viperin expression in vivo during acute lymphocytic choriomeningitis virus Armstrong infection, which induces high levels of type I IFNs, and in persistently infected ..
  94. pmc Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection
    Frederik Graw
    Institute of Integrative Biology, ETH Zurich, Universitatstrasse 16, 8092 Zurich, Switzerland
    Proc Biol Sci 278:3395-402. 2011
    ..the killing efficacy of CD8(+) T-cell responses in mice acutely and persistently infected with the lymphocytic choriomeningitis virus, using an in vivo CTL killing assay...
  95. ncbi CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system
    Jeanette Erbo Christensen
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
    J Immunol 176:4235-43. 2006
    ..This was done through analysis of CXCL10-deficient mice infected intracerebrally with lymphocytic choriomeningitis virus, which in normal immunocompetent mice induces a fatal CD8(+) T cell-mediated meningoencephalitis...
  96. ncbi Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection
    Dirk Homann
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:6239-50. 2004
    ..In this study we use the lymphocytic choriomeningitis virus system for persistent viral infection of its natural murine host and use analytical techniques ..
  97. pmc Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain
    Juan Ledesma
    Universidad de Alcala, Madrid, Spain
    Emerg Infect Dis 15:1677-80. 2009
    To clarify the presence of lymphocytic choriomeningitis virus (LCMV) in Spain, we examined blood and tissue specimens from 866 small mammals. LCMV RNA was detected in 3 of 694 wood mice (Apodemus sylvaticus)...
  98. pmc Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest
    Sebastien F Emonet
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:3473-8. 2009
    ..However, the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) has proven to be a Rosetta stone for the investigation of virus-host interactions...
  99. pmc The nucleoprotein of lymphocytic choriomeningitis virus facilitates spread of persistent infection through stabilization of the keratin network
    Martina Labudova
    Institute of Virology, Bratislava, Slovak Republic
    J Virol 83:7842-9. 2009
    b>Lymphocytic choriomeningitis virus (LCMV) is a prototypic arenavirus containing a bisegmented single-stranded RNA genome with an ambisense coding strategy...
  100. pmc Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong
    Markus J Hofer
    School of Molecular and Microbial Biosciences and the Bosch Institute, The University of Sydney, New South Wales, Australia
    Viral Immunol 21:425-33. 2008
    Intracranial infection of mice with lymphocytic choriomeningitis virus (LCMV) results in a lethal neurological disease termed lymphocytic choriomeningitis (LCM) that is mediated by antiviral CD8(+) T cells...
  101. pmc Dendritic cells efficiently induce protective antiviral immunity
    B Ludewig
    Institute of Experimental Immunology, Zurich, Switzerland
    J Virol 72:3812-8. 1998
    ..In this study, we assessed the potential of DC, either pulsed with the lymphocytic choriomeningitis virus (LCMV)-specific peptide GP33-41 or constitutively expressing the respective epitope, to induce ..

Research Grants63

  1. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..I recently reported that in vivo infection of mice with Lymphocytic choriomeningitis virus (LCMV) differentially modulates subsequent TLR challenges inhibiting TLR3, TLR7 and TLR9 ..
  2. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..Using infectious agents such as lymphocytic choriomeningitis virus and Listeria monocytogenes to infect mice we will probe the contribution of CD4+ T cells during ..
  3. Regulation of CD8 T Cell Immunity by CDK Inhibitor p27Kip1
    Marulasiddappa Suresh; Fiscal Year: 2012
    ..Our studies using the mouse model of lymphocytic choriomeningitis virus (LCMV) have shown that genetic deficiency of cyclin dependent kinase inhibitor p27Kip1 not only ..
  4. Novel Screen to Identify Arenavirus Inhibitors
    Juan Lama; Fiscal Year: 2013
    ..To overcome this problem, we have generated recombinant lymphocytic choriomeningitis viruses (rLCMV) expressing reporter genes of interest...
  5. MOUSE MODELS FOR UNDERSTANDING HOST RESPONES TO INTRACELLULAR PATHOGENS
    Ellen A Robey; Fiscal Year: 2010
    ..selected mutant mice/cells to several NIAID priority pathogens (Toxoplasma gondii, Influenza, Vaccinia, Lymphocytic Choriomeningitis virus) and other pathogens (Murine &Human cytomegalovirus, Murine herpes virus 68, Moloney Murine ..
  6. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2012
    ..and Omann's syndrome;and mouse models of three infectious diseases: schistosomiasis, malaria, and lymphocytic choriomeningitis virus (LCMV) infection...
  7. Characterizing Inflammation And Downstream Effects During Chronic Viral Infection
    Elina I Zuniga; Fiscal Year: 2012
    ..We have therefore chosen to use chronic lymphocytic choriomeningitis virus (LCMV) infection of its natural host, the mouse, as a model system...
  8. Single-cycle Infectious Candid#1 to Study Hemorrhagic Fever New World Arenavirus
    Luis Martinez-Sobrido; Fiscal Year: 2013
    ..for the first time, the generation of a single-cycle infectious, reporter-expressing, Old World Lymphocytic Choriomeningitis Virus (LCMV) where we replaced the viral glycoprotein (GP) with a reporter green fluorescent protein (..
  9. Evaluation of LASV Protective Immunity in Mice Using Reassortant Virus ML29
    MARCO AURELIO GOICOCHEA; Fiscal Year: 2010
    ..p.) immunization, similar to the closely related prototype arenavirus lymphocytic choriomeningitis virus (LCMV)...
  10. Host Genetic Factors to Combat Lassa Hemorrhagic Fever
    Michael B Oldstone; Fiscal Year: 2013
    ..Lessons learned from lymphocytic choriomeningitis virus (LCMV) are applied to Lassa fever virus (LASV)...
  11. Mechanisms of CD8+ T Cell Apoptosis During Acute and Chronic Viral Infections
    JASON MITCHELL GRAYSON; Fiscal Year: 2010
    ..any one death receptor results in delayed contraction of antigen-specific CD8+ T cells following acute lymphocytic choriomeningitis virus (LCMV) infection but cell numbers eventually decline...
  12. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
    ..In response to hematopoietic stress induced by lymphocytic choriomeningitis virus (LCMV) infection or chemotherapy, Nlrp1aQ593P/Q593P mice fail to repopulate myeloid, lymphoid and ..
  13. Signaling and Metabolism in CD8 T cell Exhaustion During Chronic Infection
    MATTHEW MICHAL STARON; Fiscal Year: 2012
    ..virus (HIV), hepatitis C or B virus (HCV, HBV) and herpes viruses (CMV, EBV, HSV) in humans and lymphocytic choriomeningitis virus (LCMV) Clone 13 (Cl13) in mice, the virus is able to evade immune detection and can persist in a ..
  14. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael B Oldstone; Fiscal Year: 2013
    ..model for study, analysis and obtaining strategies to control persistent viral infections is lymphocytic choriomeningitis virus (LCMV) infection in it murine host...
  15. Type 1 IFN Function and Signaling in Immunity to Viruses
    CHRISTINE ANNE BIRON; Fiscal Year: 2013
    ..will be advanced by studies of responses ex vivo following exposure to cytokines, and in vivo following lymphocytic choriomeningitis virus infections in wild type and genetically altered mice...
  16. GP130 Signaling During Chronic Virus Infection
    Elina I Zuniga; Fiscal Year: 2013
    ..We have therefore chosen to use chronic lymphocytic choriomeningitis virus (LCMV) infection of its natural host, the mouse, as a model system...
  17. RAS and injury: ACE and resistance to cancer and viral infection
    Kenneth E Bernstein; Fiscal Year: 2010
    ..We also studied the response of ACE 10/10 mice to infection by clone 13 of the lymphocytic choriomeningitis virus (LCMV). This stain of LCMV results in a chronic viral infection...
  18. The Role of Leukocyte Sequestration in the Control of Viral Infections
    John Altman; Fiscal Year: 2009
    ..Recently, we made the unexpected discovery that a strain of lymphocytic choriomeningitis virus (LCMV) that is normally rapidly cleared by immmunocompetent micethe Armstrong straininduces a ..
  19. Nedd4-family ubiquitination networks that regulate T cell function
    PAULA MARIA OLIVER; Fiscal Year: 2012
    ..To study whether Nedd4 is required for cell-mediated immune responses, we will use the Lymphocytic Choriomeningitis Virus (LCMV) infection model...
  20. Transcriptional regulation of CD8+ T cell differentiation
    Arnob Banerjee; Fiscal Year: 2013
    ..Eomes) and T-bet, develop an inappropriate effector CD8+ T cell response to acute infection with lymphocytic choriomeningitis virus (LCMV), fail to clear the infection, and die from inappropriate CD8+ T cell interleukin-17 ..
  21. Enhancement of HIV-specific CD4+ T cell function by blockade of the PD-1 pathway
    Brent Palmer; Fiscal Year: 2009
    ..of virus-specific CD8+ T cells both in subjects with chronic HIV infection and in mice infected with lymphocytic choriomeningitis virus (LCMV), a model system for T cell dysfunction induced by chronic viral infection...
  22. The Regulation of T Cell Exhaustion by Adhesion Molecules
    Allan J Zajac; Fiscal Year: 2013
    ..by applicant): During chronic infections such as those caused by HIV-1, hepatitis C virus, and lymphocytic choriomeningitis virus, as well as during tumor outgrowth, antigen-specific CD8 T cells often progressively lose ..
  23. Inhibitory Pathways Underlying Viral Persistance in vivo
    Elina I Zuniga; Fiscal Year: 2013
    ..By using in vivo chronic lymphocytic choriomeningitis virus (LCMV) infection in mice, we recently found that specific and exclusive attenuation of TGF? ..
  24. Type 1 IFN Function and Signaling in Immunity to Viruses
    Christine Biron; Fiscal Year: 2009
    ..will be advanced by studies of responses ex vivo following exposure to cytokines, and in vivo following lymphocytic choriomeningitis virus infections in wild type and genetically altered mice...
  25. CD4+ T cell affinity for self and foreign antigens in the CNS
    Brian D Evavold; Fiscal Year: 2013
    ..on CD4+ T cells specific for self antigen myelin oligodendrocyte glycoprotein and pathogen associated lymphocytic choriomeningitis virus antigens...
  26. Regulation of chronic viral infection by co-inhibitory pathways
    Arlene H Sharpe; Fiscal Year: 2013
    ..We are using the lymphocytic choriomeningitis virus (LCMV) model to investigate how inhibitory pathways in the B7:CD28 family regulate T cell ..
  27. Structure and Function of MHC Proteins
    Lawrence J Stern; Fiscal Year: 2013
    ..The fifth aim is to characterize the structural basis for T cell crossreactivity of epitopes from vaccina virus and lymphocytic choriomeningitis virus.
  28. Mechanisms of Viral Persistence
    David G Brooks; Fiscal Year: 2013
    ..We discovered that infection with a persistent strain of lymphocytic choriomeningitis virus (LCMV) triggers high IL-10 production that directly ablates T cell function and causes viral ..
  29. Molecular basis of defective CD8 T cells during chronic viral infection
    Hao Shen; Fiscal Year: 2010
    ..Using infection of mice with lymphocytic choriomeningitis virus (LCMV) as a model, we have discovered that memory CD8 T cells generated in the absence of CD4 T ..
  30. Regulation of chronic viral infection by co-inhibitory pathways
    Arlene Sharpe; Fiscal Year: 2009
    ..During the current funding period, we have used the lymphocytic choriomeningitis virus (LCMV) model to investigate how inhibitory pathways in the B7:CD28 family regulate T cell ..
  31. Immune Regulation of Viral Persistence and Clearance
    David G Brooks; Fiscal Year: 2013
    ..To achieve this goal we will use the mouse model of lymphocytic choriomeningitis virus (LCMV) infection to explore virus-specific CD4 T helper differentiation during viral persistence ..
  32. DELIVERY OF PROTEINS INTO CYTOSOL USING LLO-LIPOSOMES
    Kyung Dall Lee; Fiscal Year: 2002
    ..as a vaccine delivery vehicle, and will therefore be extended to a well-established mouse model of lymphocytic choriomeningitis virus (LCMV) infection...
  33. DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2009
    ..aim we will examine the mechanism of Spi2A upregulation in memory-cell precursors after infection with Lymphocytic choriomeningitis virus (LCMV)...
  34. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2001
    ..the role of TNF receptors (TNFRs) in regulating the generation of CD8+ memory T cells using the lymphocytic choriomeningitis virus (LCMV) model in mice...
  35. MUCOSAL INFECTION WITH ARENAVIRUS
    Igor Lukashevich; Fiscal Year: 2000
    ..The prototype arenavirus, lymphocytic choriomeningitis virus (LCMV), has frequently been used to study cell-mediated immunity in inbred mice...
  36. RECOMBINANT L MONOCYTOGENES AS AN SIV VACCINE
    Andrew Kaplan; Fiscal Year: 2000
    ..applicant has used this system to elicit protective immunity in three animal models of viral disease, lymphocytic choriomeningitis virus infection of mice as well as HTLV-1 and cottontail rabbit papilloma virus infection of rabbits...
  37. ROLE OF FUCOSYLTRANSEFERASE IN ANTIVIRAL CYTOTOXICITY
    MANJUNATH SWAMY; Fiscal Year: 2000
    ..In Aim 1, we will breed FT-/- mice to mice transgenic (Tg) to lymphocytic choriomeningitis (LCMV) glycoprotein TCR...
  38. Mechanisms of CD4 T cell help for CD8 T cells during persistent viral infection
    Jeffrey Scott Hale; Fiscal Year: 2013
    ..The well- characterized lymphocytic choriomeningitis virus (LCMV) will be used to investigate the contribution of CD4 T cells following severe CD8 T cell ..
  39. REPLICATION AND SPREAD OF NEUROTROPIC VIRUSES
    Glenn Rall; Fiscal Year: 2001
    ..will be used to compare the outcome of neuronal infection caused by two neurotropic viruses, namely, lymphocytic choriomeningitis virus (LCMV) and measles virus (MV)...
  40. Expansion of Rodent Biocontainment at the University of Missouri
    LONNY DIXON; Fiscal Year: 2009
    ..Biocontainment space is needed to safely study infectious organisms such as Streptococcus Group A, lymphocytic choriomeningitis virus, and Listeria monocytogenes, all of which can infect humans, causing such diseases as strep ..
  41. The Role of Memory T-Cells in Pathogenesis
    JOSEPH KISSIL; Fiscal Year: 2009
    ..and modify the model to include two well-defined T cell epitopes (a CD4 and a CD8 epitope) from lymphocytic choriomeningitis virus (LCMV), GP33 and GP61, fused directly to the N-terminus of the oncogenic activated K-ras protein...
  42. RECOMBINANT LISTERIA VACCINES FOR MELANOMA
    JEFFERY MILLER; Fiscal Year: 2003
    ..monocytogenes. Recombinant vaccine strains expressing the lymphocytic choriomeningitis virus (LCMV) nucleoprotein (NP), or a specific MHC class I restricted NP epitope, are able to induce ..
  43. 'ROLE OF SELF-PEPTIDES IN THE SELECTION OF T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2005
    ..which are recognized by CTLs specific for two different pathogenic viruses, Influenza (IF) and Lymphocytic Choriomeningitis virus (LCMV)...
  44. MOLECULAR DETERMINANTS OF THE CYTOTOXIC T CELL RESPONSE
    Maria Salvato; Fiscal Year: 1992
    ..The studies proposed here will use laboratory mice infected with lymphocytic choriomeningitis virus (LCMV)...
  45. Cell immune responses in SIV-infected sooty mangabeys
    Amitinder Kaur; Fiscal Year: 2004
    ..or SIV infection, they can also cause disease by inducing immunopathology, as in certain instances of lymphocytic choriomeningitis virus infection in mice...
  46. IL-1 dependent anorexia during CNS viral infection
    David Hildeman; Fiscal Year: 2007
    ..c.) lymphocytic choriomeningitis virus (LCMV) infection...
  47. ROLE OF FUCOSYLTRANSFERASE IN ANTIVIRAL CYTOTOXICITY
    MANJUNATH SWAMY; Fiscal Year: 2004
    ..In Aim 1, we will breed FT-/- mice to mice transgenic (Tg) to lymphocytic choriomeningitis (LCMV) glycoprotein TCR...
  48. CTL pathogenesis after infection of vaccinated host
    John Harty; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Perforin-mediated cytolysis is essential for clearance of lymphocytic choriomeningitis virus (LCMV) and perforin-deficient mice are models for familial hemophagocytic lymphohistiocytosis (FHL), a ..
  49. Persistence of LCMV by exhaustion of antiviral T cells
    DIMITRIOS MOSKOFIDIS; Fiscal Year: 2006
    ..Viral persistence following infection with invasive strains of lymphocytic choriomeningitis virus (LCMV) can be achieved by selective down-regulation ("clonal exhaustion") of the virus-specific T ..
  50. EXERCISE INDUCED IMMUNOMODULATION IN AGING
    ZOHER KAPASI; Fiscal Year: 2000
    ..in young and aged mice by evaluating the humoral and cell-mediated immune responses in a mouse model of lymphocytic choriomeningitis virus (LCMV) infection...
  51. Acquired susceptibility to pulmonary TB
    Hardy Kornfeld; Fiscal Year: 2009
    ..We discovered that infection of mice with lymphocytic choriomeningitis virus (LCMV), human pathogen, increases TB susceptibility and alters the pattern of immunopathology in ..
  52. T cell memory
    Joshy Jacob; Fiscal Year: 2005
    ..We will use this model system to probe lymphocytic choriomeningitis (LCMV) virus-induced immune responses and the differentiation pathway of immune memory generation...
  53. Functional analyses of antiviral CD4+ T cell responses
    J Whitton; Fiscal Year: 2002
    ..they represent the two ends of the immunological spectrum; one induces strong CD8+ T cell responses [lymphocytic choriomeningitis virus (LCMV)], while the other induces strong CD4+ T cell/antibody responses [coxsackievirus B3 (CVB3)]...
  54. MIP1 ALPHA AND PROTECTIVE ANTIVIRAL IMMUNITY
    Daniel Quinn; Fiscal Year: 2003
    ..We are investigating the mechanisms of protective antiviral T cell responses using lymphocytic choriomeningitis virus (LCMV) infection of mice as a model system...
  55. ROLE OF TYPE-I IFN'S IN ANTIVIRAL CD8 CELL RESPONSE
    Murali Krishna Kaja; Fiscal Year: 2007
    ..Our previous studies, using mouse models of lymphocytic choriomeningitis virus (LCMV) infection, demonstrated that acute viral infections induce a much higher magnitude of ..
  56. Dissection of the Anti-tumor Immune Response
    Erik Ranheim; Fiscal Year: 2006
    ..In addition, these tumors will express well characterized viral antigens from murine lymphocytic choriomeningitis virus, nucleoprotein (NP) and glycoprotein (GP) for use as model tumor antigens...
  57. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  58. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  59. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  60. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  61. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  62. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  63. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..