herpes simplex

Summary

Summary: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)

Top Publications

  1. ncbi Chromatin control of herpes simplex virus lytic and latent infection
    David M Knipe
    Harvard Medical School, Department of Microbiology and Molecular Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Microbiol 6:211-21. 2008
  2. ncbi Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Thomas Gebhardt
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia
    Nat Immunol 10:524-30. 2009
  3. pmc Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management
    Jocelyne Piret
    Centre de Recherche en Infectiologie, Universite Laval, Quebec, Quebec, Canada
    Antimicrob Agents Chemother 55:459-72. 2011
  4. pmc Live attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread
    Sita Awasthi
    Infectious Disease Division, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Virol 86:4586-98. 2012
  5. pmc TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice
    Line S Reinert
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Clin Invest 122:1368-76. 2012
  6. pmc A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency
    Yu Liang
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 4:e00558-12. 2013
  7. ncbi Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 190:693-6. 2004
  8. ncbi Viral and cellular contributions to herpes simplex virus entry into the cell
    Gabriella Campadelli-Fiume
    Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Curr Opin Virol 2:28-36. 2012
  9. pmc Endocytic tubules regulated by Rab GTPases 5 and 11 are used for envelopment of herpes simplex virus
    Michael Hollinshead
    Section of Virology, Faculty of Medicine, Imperial College London, London, UK
    EMBO J 31:4204-20. 2012
  10. ncbi The cycle of human herpes simplex virus infection: virus transport and immune control
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, 2145, Australia
    J Infect Dis 194:S11-8. 2006

Detail Information

Publications295 found, 100 shown here

  1. ncbi Chromatin control of herpes simplex virus lytic and latent infection
    David M Knipe
    Harvard Medical School, Department of Microbiology and Molecular Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Microbiol 6:211-21. 2008
    b>Herpes simplex viruses (HSV) can undergo a lytic infection in epithelial cells and a latent infection in sensory neurons...
  2. ncbi Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Thomas Gebhardt
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia
    Nat Immunol 10:524-30. 2009
    ..Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia...
  3. pmc Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management
    Jocelyne Piret
    Centre de Recherche en Infectiologie, Universite Laval, Quebec, Quebec, Canada
    Antimicrob Agents Chemother 55:459-72. 2011
    b>Herpes simplex viruses (HSV) type 1 and type 2 are responsible for recurrent orolabial and genital infections...
  4. pmc Live attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread
    Sita Awasthi
    Infectious Disease Division, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Virol 86:4586-98. 2012
    A herpes simplex virus 2 (HSV-2) glycoprotein E deletion mutant (gE2-del virus) was evaluated as a replication-competent, attenuated live virus vaccine candidate...
  5. pmc TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice
    Line S Reinert
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Clin Invest 122:1368-76. 2012
    b>Herpes simplex viruses (HSVs) are highly prevalent neurotropic viruses...
  6. pmc A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency
    Yu Liang
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 4:e00558-12. 2013
    ..Infection of cells with alphaherpesviruses (herpes simplex virus [HSV] and varicella-zoster virus [VZV]) results in the deposition of nucleosomes bearing repressive ..
  7. ncbi Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 190:693-6. 2004
    The effect of highly active antiretroviral therapy (HAART) on control of herpes simplex virus (HSV) in human immunodeficiency virus (HIV) type 1-infected subjects is not known...
  8. ncbi Viral and cellular contributions to herpes simplex virus entry into the cell
    Gabriella Campadelli-Fiume
    Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Curr Opin Virol 2:28-36. 2012
    b>Herpes simplex virus (HSV) entry into the cell involves the fusion of the virion envelope with a cellular membrane and delivery of capsid and tegument proteins to the cytoplasm...
  9. pmc Endocytic tubules regulated by Rab GTPases 5 and 11 are used for envelopment of herpes simplex virus
    Michael Hollinshead
    Section of Virology, Faculty of Medicine, Imperial College London, London, UK
    EMBO J 31:4204-20. 2012
    ..Here, an ultrastructural study of herpes simplex virus 1 (HSV1)-infected cells revealed envelopment in tubular membranes...
  10. ncbi The cycle of human herpes simplex virus infection: virus transport and immune control
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, 2145, Australia
    J Infect Dis 194:S11-8. 2006
    After infection of skin or mucosa, herpes simplex virus enters the sensory nerve endings and is conveyed by retrograde axonal transport to the dorsal root ganglion, where the virus develops lifelong latency...
  11. pmc Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism
    Livia Vastag
    Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 7:e1002124. 2011
    ..we used mass spectrometry to examine the impact of two related herpesviruses, human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1), on the metabolism of fibroblast and epithelial host cells...
  12. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells...
  13. ncbi Immunity to latent viral infection: many skirmishes but few fatalities
    Kamal M Khanna
    Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2588, USA
    Trends Immunol 25:230-4. 2004
  14. pmc An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection
    Katharine J Looker
    Department of Infectious Disease Epidemiology, Imperial College London, London, England
    Bull World Health Organ 86:805-12, A. 2008
    To estimate the global prevalence and incidence of herpes simplex virus type 2 (HSV-2) infection in 2003.
  15. pmc Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:1315-20. 2004
    Human neonates infected with herpes simplex virus 1 (HSV-1) develop one of three distinct patterns of infection: (i) infection limited to the skin, eye or mouth; (ii) infection of the CNS; or (iii) disseminated infection...
  16. pmc Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection
    Qing Yin Wang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:16055-9. 2005
    b>Herpes simplex virus (HSV) persists in its human host and evades the immune response by undergoing a latent infection in sensory neurons, from which it can reactivate periodically...
  17. pmc Defining the herpes simplex virus-specific CD8+ T cell repertoire in C57BL/6 mice
    Anthony J St Leger
    Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 186:3927-33. 2011
    ....
  18. pmc Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters
    Anna R Cliffe
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Virol 83:8182-90. 2009
    ..In the case of herpesviruses, herpes simplex virus (HSV) infection of epithelial cells results in a lytic infection, whereas latent infection is ..
  19. pmc Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    Kamal M Khanna
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 18:593-603. 2003
    This study challenges the concept that herpes simplex virus type 1 (HSV-1) latency represents a silent infection that is ignored by the host immune system, and suggests antigen-directed retention of memory CD8(+) T cells...
  20. pmc Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 198:1804-8. 2008
    A randomized cross-over trial of herpes simplex virus type 2 (HSV-2)-suppressive therapy (valacyclovir, 500 mg twice daily, or placebo for 8 weeks, a 2-week washout period, then the alternative therapy for 8 weeks) was conducted among 20 ..
  21. pmc Development of a glycoprotein D-expressing dominant-negative and replication-defective herpes simplex virus 2 (HSV-2) recombinant viral vaccine against HSV-2 infection in mice
    Natalie V Akhrameyeva
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Virol 85:5036-47. 2011
    Using the T-REx (Invitrogen, California) gene switch technology and a dominant-negative mutant polypeptide of herpes simplex virus 1 (HSV-1)-origin binding protein UL9, we previously constructed a glycoprotein D-expressing replication-..
  22. pmc αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts
    Tatiana Gianni
    Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Virol 86:2850-5. 2012
    b>Herpes simplex virus (HSV) enters cells by fusion at plasma membranes or endosomes. Cellular factors route the virus to different pathways. αVβ3-integrin directs HSV to a lipid raft and acidic endosome pathway...
  23. pmc Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine
    Lichen Jing
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Clin Invest 122:654-73. 2012
    b>Herpes simplex virus type 1 (HSV-1) not only causes painful recurrent oral-labial infections, it can also cause permanent brain damage and blindness. There is currently no HSV-1 vaccine...
  24. ncbi A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sex Transm Dis 35:78-83. 2008
    ..The etiology of bacterial vaginosis (BV) is poorly understood, but better definition of the risk factors associated with its acquisition should improve our understanding of this complex disease entity...
  25. pmc The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex virus
    Julia Schipke
    Institute of Virology, Hannover Medical School, Hannover, Germany
    J Virol 86:3682-700. 2012
    The largest tegument protein of herpes simplex virus type 1 (HSV1), pUL36, is a multivalent cross-linker between the viral capsids and the tegument and associated membrane proteins during assembly that upon subsequent cell entry releases ..
  26. pmc Role of specific innate immune responses in herpes simplex virus infection of the central nervous system
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:2273-81. 2012
    b>Herpes simplex virus 1 (HSV-1) causes a spectrum of disease, including herpes labialis, herpes keratitis, and herpes encephalitis, which can be lethal...
  27. pmc Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus
    Charles E Isaacs
    Department of Developmental Biochemistry, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Antimicrob Agents Chemother 52:962-70. 2008
    In the absence of a fully effective herpes simplex virus (HSV) vaccine, topical microbicides represent an important strategy for preventing HSV transmission. (-)-Epigallocatechin gallate (EGCG) (molecular weight, 458...
  28. pmc Detection of Herpes simplex virus DNA by real-time PCR
    H H Kessler
    Institute of Hygiene, Karl Franzens University Graz, A 8010 Graz, Austria
    J Clin Microbiol 38:2638-42. 2000
    Molecular detection of herpes simplex virus (HSV) DNA is recognized as the reference standard assay method for the sensitive and specific diagnosis of central nervous system infections caused by HSV...
  29. pmc Toll-like receptor (TLR) 2 and TLR9 expressed in trigeminal ganglia are critical to viral control during herpes simplex virus 1 infection
    Graciela Kunrath Lima
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Laboratorio de Imunopatologia, CPqRR FIOCRUZ Av Augusto de Lima, 1715 CEP 30 190 002 Belo Horizonte, MG, Brazil
    Am J Pathol 177:2433-45. 2010
    b>Herpes simplex virus 1 (HSV-1) is a neurotropic DNA virus that is responsible for several clinical manifestations in humans, including encephalitis. HSV-1 triggers toll-like receptors (TLRs), which elicit cytokine production...
  30. pmc The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1
    Brandon J Placek
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennysylvania 19104, USA
    J Virol 83:1416-21. 2009
    ..In this report we use lytic infection by herpes simplex virus type 1 (HSV-1) as a model to examine the temporal profile of histone H3 incorporation and to determine ..
  31. pmc Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB
    Valerio Leoni
    Department of Experimental Pathology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Virol 86:6555-62. 2012
    A number of sentinels sense incoming herpes simplex virus (HSV) virions and initiate an immediate innate response...
  32. ncbi Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
    Jun Arii
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nature 467:859-62. 2010
    b>Herpes simplex virus-1 (HSV-1), the prototype of the α-herpesvirus family, causes life-long infections in humans. Although generally associated with various mucocutaneous diseases, HSV-1 is also involved in lethal encephalitis...
  33. pmc Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes
    Roger D Everett
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 83:4963-77. 2009
    b>Herpes simplex virus type 1 (HSV-1) immediate-early regulatory protein ICP0 is important for stimulating the initiation of the lytic cycle and efficient reactivation of latent or quiescent infection...
  34. ncbi Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States
    Fujie Xu
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 296:964-73. 2006
    b>Herpes simplex virus type 1 (HSV-1) and type 2 are common infections worldwide. Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes and is almost always sexually transmitted...
  35. pmc The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency
    Dacia L Kwiatkowski
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, 32610 0266, USA
    J Virol 83:8173-81. 2009
    The mechanism by which herpes simplex virus 1 (HSV-1) establishes latency in sensory neurons is largely unknown...
  36. pmc Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
    b>Herpes simplex virus (HSV) remains latent in nerve root ganglia of infected persons and is thought to reactivate several times yearly...
  37. pmc CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Exp Med 198:889-901. 2003
    ..Thus, controlling suppressor effects at the time of vaccination could result in more effective immunity...
  38. pmc The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection
    Aarthi Narayanan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4 131, 4 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:10835-40. 2007
    Originally identified as an essential component of the herpes simplex virus immediate early (IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has been implicated in a broad range of cellular regulatory ..
  39. ncbi Herpes simplex: insights on pathogenesis and possible vaccines
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Annu Rev Med 59:381-95. 2008
    Abstract Herpes simplex viruses are evolutionarily ancient and ubiquitous. In the past 20 years, there has been increasing recognition of a worldwide pandemic of HSV-2 infection...
  40. ncbi Herpes simplex virus epidemiology and ocular importance
    T J Liesegang
    Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Cornea 20:1-13. 2001
    To review the changing epidemiology of herpes simplex disease and correlate it with the epidemiology of ocular herpes simplex disease.
  41. ncbi Herpes simplex virus and HIV-1: deciphering viral synergy
    Philippe Van de Perre
    EA 4205 Transmission, Pathogenèse et Prévention de l Infection par le VIH, Université Montpellier 1 and Laboratories of Bacteriology and Virology, CHU Montpellier, Montpellier, France
    Lancet Infect Dis 8:490-7. 2008
    Recent proof-of-concept randomised controlled trials have shown a causal relation between herpes simplex virus (HSV) type 2 infection and HIV-1 replication in co-infected individuals...
  42. pmc Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication
    Kevin F Bryant
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    MBio 2:e00330-10. 2011
    Like other DNA viruses that replicate in the nucleus, herpes simplex virus 1 (HSV-1) regulates the association of histones with its genome to promote viral replication and gene expression...
  43. pmc An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection
    Tao Peng
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Virol 86:10587-96. 2012
    b>Herpes simplex virus 2 infection is characterized by cycles of viral quiescence and reactivation...
  44. pmc Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways
    Hubertus Hochrein
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 101:11416-21. 2004
    Type I IFN production in response to the DNA virus herpes simplex virus type-1 (HSV-1) is essential in controlling viral replication...
  45. pmc Prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection
    Thessicar E Antoine
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, IL 60612, USA
    Antiviral Res 96:363-75. 2012
    The attachment of Herpes simplex virus type-2 (HSV-2) to a target cell requires ionic interactions between negatively charged cell surface co-receptor heparan sulfate (HS) and positively charged residues on viral envelop glycoproteins, gB ..
  46. pmc Recent progress in herpes simplex virus immunobiology and vaccine research
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Microbiol Rev 16:96-113. 2003
    b>Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes...
  47. ncbi Marine organisms as a therapeutic source against herpes simplex virus infection
    Thanh Sang Vo
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Eur J Pharm Sci 44:11-20. 2011
    b>Herpes simplex virus (HSV) is a member of the Herpesviridae family that causes general communicable infections in human populations throughout the world, the most common being genital and orolabial disease...
  48. ncbi Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues
    Bernard Roizman
    Marjorie B Kovler Viral Oncology Laboratories, The University of Chicago, 910 East 58th Street, Chicago, IL 60637, USA
    J Neurovirol 17:512-7. 2011
    The fundamental question posed here is why in dorsal root ganglia herpes simplex viruses (HSV) can establish a silent infection in which only latency associate transcripts (LAT) and miRNAs are expressed and the neuronal cell survives ..
  49. pmc DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication
    Kareem N Mohni
    Department of Molecular, Microbial, and Structural Biology and Molecular Biology and Biochemistry Graduate Program, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    J Virol 85:12241-53. 2011
    b>Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of its human host cell and is known to interact with many cellular DNA repair proteins...
  50. pmc Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1
    Zhuan Li
    Department of Virology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    J Virol 86:492-503. 2012
    ..In this study, we found that herpes simplex virus (HSV) infection induced extensive modification of tankyrase 1 but not tankyrase 2...
  51. pmc Impact of herpes simplex virus type 2 on HIV-1 acquisition and progression in an HIV vaccine trial (the Step study)
    Ruanne V Barnabas
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 57:238-44. 2011
    Extensive observational data suggest that herpes simplex virus type 2 (HSV-2) infection may facilitate HIV acquisition, increase HIV viral load, and accelerate HIV progression and onward transmission...
  52. ncbi Roles played by toll-like receptor-9 in corneal endothelial cells after herpes simplex virus type 1 infection
    Sachiko Takeda
    Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Tottori, Japan
    Invest Ophthalmol Vis Sci 52:6729-36. 2011
    To determine the roles played by toll-like receptor 9 (TLR9) in cultured human corneal endothelial (HCEn) cells after herpes simplex virus type 1 (HSV-1) infection and to characterize the TLR9-mediated antiviral responses.
  53. ncbi Natural history of neonatal herpes simplex virus infections in the acyclovir era
    D W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatrics 108:223-9. 2001
    During the 2 decades in which effective antiviral therapies have been available for neonatal herpes simplex virus (HSV) disease, changes have been documented not only in the outcomes of infected infants, but also in the natural history of ..
  54. pmc Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory ganglia
    Allison L van Lint
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville 3010, Victoria, Australia
    J Virol 79:14843-51. 2005
    CD8+ T-cell persistence can be seen in ganglia harboring latent herpes simplex virus (HSV) infection. While there is some evidence that these cells suppress virus reactivation, this view remains controversial...
  55. ncbi The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway
    Sebastian Temme
    Section of Immunobiology, Institute of Genetics, University of Bonn, Bonn, Germany
    J Immunol 184:236-43. 2010
    ..In conclusion, this is a previously undescribed mode of viral immune evasion involving hijacking of DR from its normal transport route to the cell surface, followed by viral-mediated release of DR into the exosome pathway...
  56. ncbi Herpes simplex virus infection downmodulates NKG2D ligand expression
    D Schepis
    Department of Microbiology, Tumor and Cell Biology and Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 69:429-36. 2009
    b>Herpes simplex virus (HSV) type 1 infection may cause orofacial infections in humans. The virus resides in a latent form in neural ganglia and occasionally reactivates and infects epithelial cells...
  57. pmc The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing
    Xianzhi Jiang
    University of California, Irvine, Dept of Ophthalmology, Orange, CA 92868, USA
    J Virol 85:2325-32. 2011
    The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only HSV-1 gene transcript abundantly expressed throughout latency. LAT null mutants have a significantly reduced reactivation phenotype...
  58. ncbi Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome
    Robin Antrobus
    Oxford Glycobiology Institute, Department of Biochemistry, Oxford University, UK
    Proteomics 9:3913-27. 2009
    During infection by herpes simplex virus type-1 (HSV-1) the host cell undergoes widespread changes in gene expression and morphology in response to viral replication and release...
  59. ncbi Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    b>Herpes simplex virus type 2 (HSV-2) infection is common among human immunodeficiency virus (HIV)-infected persons, and HSV reactivation increases plasma and genital HIV-1 levels...
  60. pmc SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes
    Delphine Cuchet-Lourenço
    MRC University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
    PLoS Pathog 7:e1002123. 2011
    Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus...
  61. pmc Zinc salts inactivate clinical isolates of herpes simplex virus in vitro
    M Arens
    The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Microbiol 38:1758-62. 2000
    Using a standard plaque assay and clinical isolates of herpes simplex virus (HSV), we have tested the ability of zinc salts to inactivate HSV...
  62. ncbi Maternal Herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study
    Frances M Cowan
    Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, UK
    AIDS 22:193-201. 2008
    Genital ulcer disease including that caused by Herpes simplex virus type 2 (HSV-2) and syphilis facilitates sexual transmission of HIV-1...
  63. pmc Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency
    Gregory M Frank
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 184:277-86. 2010
    ..CD4(+) T cells are not needed to maintain CD8(+) T cell memory through 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency...
  64. ncbi Herpes simplex virus resistance to antiviral drugs
    Florence Morfin
    Laboratory of Virology of the Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Cedex 08, Lyon, France
    J Clin Virol 26:29-37. 2003
    b>Herpes simplex virus (HSV) infections are efficiently treated with antiviral drugs such as acyclovir (ACV)...
  65. pmc Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice
    Gary D Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:12149-61. 2002
    Mouse models of herpes simplex virus type 1 (HSV-1) infection provide significant insights into viral and host genes that regulate disease pathogenesis, but conventional methods to determine the full extent of viral spread and replication ..
  66. ncbi The neurotropic herpes viruses: herpes simplex and varicella-zoster
    Israel Steiner
    Neurological Sciences Unit, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    Lancet Neurol 6:1015-28. 2007
    b>Herpes simplex viruses types 1 and 2 (HSV1 and HSV2) and varicella-zoster virus (VZV) establish latent infection in dorsal root ganglia for the entire life of the host...
  67. ncbi A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry
    D Shukla
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell 99:13-22. 1999
    b>Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans...
  68. pmc Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26
    Katinka Döhner
    Institut fur Virologie, OE5230, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623 Hannover, Germany
    J Virol 80:8211-24. 2006
    Cytoplasmic dynein,together with its cofactor dynactin, transports incoming herpes simplex virus type 1 (HSV-1) capsids along microtubules (MT) to the MT-organizing center (MTOC)...
  69. ncbi Extracts and molecules from medicinal plants against herpes simplex viruses
    Mahmud Tareq Hassan Khan
    Pharmacology Research Laboratory, Faculty of Pharmaceutical Sciences, University of Science and Technology Chittagong, Chittagong, Bangladesh
    Antiviral Res 67:107-19. 2005
    b>Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection...
  70. pmc Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry
    Claude Krummenacher
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
    EMBO J 24:4144-53. 2005
    b>Herpes simplex virus (HSV) entry into cells requires binding of the envelope glycoprotein D (gD) to one of several cell surface receptors...
  71. ncbi Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India
    Steven J Reynolds
    Division of Infectious Diseases, School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 187:1513-21. 2003
    To estimate the impact of prevalent and incident herpes simplex virus type 2 (HSV-2) infection on the acquisition of human immunodeficiency virus type 1 (HIV-1), stored serum samples from a cohort of 2732 HIV-1-seronegative patients ..
  72. ncbi Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features
    Paolo G Arduino
    Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Turin, Italy
    J Oral Pathol Med 37:107-21. 2008
    b>Herpes Simplex Virus Type 1 (HSV-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva)...
  73. pmc Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy
    Teresa H Bacon
    GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey KT15 0DE, United Kingdom
    Clin Microbiol Rev 16:114-28. 2003
    ..3 x 10(6) kg of these nucleoside analogues, the prevalence of acyclovir resistance in herpes simplex virus isolates from immunocompetent hosts has remained stable at approximately 0.3%...
  74. pmc Rapid diagnosis of herpes simplex virus infection by a loop-mediated isothermal amplification method
    Yoshihiko Enomoto
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan 4701192
    J Clin Microbiol 43:951-5. 2005
    Primers for herpes simplex virus type 1 (HSV 1)-specific loop-mediated isothermal amplification (LAMP) method amplified HSV-1 DNA, while HSV-2-specific primers amplified only HSV-2 DNA; no LAMP products were produced by reactions ..
  75. pmc A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice
    Patric Lundberg
    Department of Virology, Beckman Research Institute, City of Hope Medical Center, Duarte, California 91010, USA
    J Virol 77:11661-73. 2003
    During studies to determine a role for tumor necrosis factor (TNF) in herpes simplex virus type 1 (HSV-1) infection using TNF receptor null mutant mice, we discovered a genetic locus, closely linked to the TNF p55 receptor (Tnfrsf1a) gene ..
  76. pmc Specific histone tail modification and not DNA methylation is a determinant of herpes simplex virus type 1 latent gene expression
    Nicole J Kubat
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610 0266, USA
    J Virol 78:1139-49. 2004
    During herpes simplex virus type 1 (HSV-1) latency, gene expression is tightly repressed except for the latency-associated transcript (LAT)...
  77. ncbi Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus
    Claude Krummenacher
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Virology 322:286-99. 2004
    The herpesvirus entry mediator A (HVEM/HveA) and nectin-1 (HveC/CD111) are two major receptors for herpes simplex virus (HSV)...
  78. ncbi Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate
    P E Pertel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois, 60611, USA
    Virology 279:313-24. 2001
    To characterize cellular factors required for herpes simplex virus type 1 (HSV-1)-induced cell fusion, we used an efficient and quantitative assay relying on expression of HSV-1 glycoproteins in transfected cells...
  79. pmc The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis
    Patric Lundberg
    Division of Virology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    J Virol 82:7078-88. 2008
    This study was undertaken to investigate possible immune mechanisms in fatal herpes simplex virus type 1 (HSV-1) encephalitis (HSE) after HSV-1 corneal inoculation...
  80. ncbi Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection
    Ehsan Hazrati
    Department of Pediatrics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Immunol 177:8658-66. 2006
    This study examined the ability of nine human defensins (HD) to protect against herpes simplex virus infection...
  81. pmc Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1
    Jing Huang
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Virol 80:5740-6. 2006
    Human herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that causes facial, ocular, and encephalitic disease in humans...
  82. pmc The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1
    Sariah J Allen
    Center for Neurobiology and Vaccine Development, D2024, Cedars Sinai Burns and Allen Research Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Virol 85:4184-97. 2011
    b>Herpes simplex virus (HSV) infection is a classic example of latent viral infection in humans and experimental animal models...
  83. pmc Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
    Either herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells. The contribution of individual receptors to infection in vivo and to disease is less clear...
  84. ncbi Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques
    M A Wozniak
    Faculty of Life Sciences, University of Manchester, UK
    J Pathol 217:131-8. 2009
    ..We previously showed that herpes simplex virus type 1 is a strong risk factor for Alzheimer's disease when in the brains of possessors of the type 4 ..
  85. ncbi Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades
    C J Carter
    Neurochem Int 52:920-34. 2008
    The products of the Herpes simplex (HSV-1) genome interact with many Alzheimer's disease susceptibility genes or proteins. These in turn affect those of the virus...
  86. ncbi Transport and egress of herpes simplex virus in neurons
    Russell J Diefenbach
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, Westmead, NSW 2145, Australia
    Rev Med Virol 18:35-51. 2008
    ..Current hypotheses suggest that unenveloped HSV capsids complete assembly in the axonal growth cones and varicosities, whereas with PrV unenveloped capsids are only found travelling in a retrograde direction...
  87. pmc A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells
    Vaibhav Tiwari
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 60612, UK
    J Virol 79:13173-9. 2005
    The human eye is an important target for infection with herpes simplex virus 1 (HSV-1). Damage to cells forming the trabeculum of the eye by HSV-1 infection could contribute to the development of glaucoma, a major blinding disease...
  88. pmc The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling
    Christopher R Cotter
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 85:12662-72. 2011
    Immune evasion is a defining feature of the virus-host relationship. During infection, herpes simplex virus type 1 (HSV-1) utilizes multiple proteins to manipulate the host immune response...
  89. ncbi CD8(+) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection
    Linda M Wakim
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 86:666-75. 2008
    During an initial encounter with herpes simplex virus type 1 (HSV-1) it takes several days for an adaptive immune response to develop and for herpes-specific CD8(+) T cells to infiltrate sites of infection...
  90. ncbi Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus
    Olaf Weber
    BAYER AG Pharmaceutical Division, Antiinfective Research, D 42096 Wuppertal, Germany
    J Gen Virol 84:1843-52. 2003
    ..PPVO protects mice from lethal herpes simplex virus type 1 infection and guinea pigs from recurrent genital herpes disease...
  91. ncbi Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation
    Allison van Lint
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Immunol 172:392-7. 2004
    ..Therefore, we propose that the role of CD8+ T cells during the normal course of disease is to clear replicating virus after infection is well established rather than limit the initial spread of HSV from the primary site of inoculation...
  92. pmc Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR
    Manfred Weidmann
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    J Clin Microbiol 41:1565-8. 2003
    The herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV) can cause life-threatening infections of the central nervous system and lead to severe infections in immunocompromised subjects and newborns...
  93. pmc Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, School of Medicine, University of California, Irvine, Irvine, CA 92697 4375, USA
    Clin Dev Immunol 2012:187585. 2012
    The best hope of controlling the herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) pandemic is the development of an effective vaccine...
  94. pmc Effect of daily aciclovir on HIV disease progression in individuals in Rakai, Uganda, co-infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 12:441-8. 2012
    Daily suppression of herpes simplex virus type 2 (HSV-2) reduces plasma HIV-1 concentrations and modestly delayed HIV-1 disease progression in one clinical trial...
  95. pmc The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, School of Medicine, University of California Irvine, Irvine, California, USA
    Viral Immunol 25:204-15. 2012
    We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG)...
  96. ncbi Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion
    Na Zhang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beichen West Road, Beijing 100101, China
    Nat Commun 2:577. 2011
    Multiple surface envelope proteins are involved in the human herpes simplex virus type 1 entry and fusion...
  97. pmc A rapid and simple isothermal nucleic acid amplification test for detection of herpes simplex virus types 1 and 2
    Hyun Jin Kim
    BioHelix Corporation, Beverly, MA 01915, United States
    J Clin Virol 50:26-30. 2011
    A simple and rapid IsoAmp HSV assay has been developed for qualitative detection of herpes simplex virus (HSV) types 1 and 2 from genital lesions...
  98. pmc Seroepidemiological study of herpes simplex virus types 1 and 2 in Brazil, Estonia, India, Morocco, and Sri Lanka
    F M Cowan
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, University College London, London, UK
    Sex Transm Infect 79:286-90. 2003
    The association between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) and the development of HSV vaccines have increased interest in the study of HSV epidemiology.
  99. pmc Loss of the type I interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection
    Christopher D Conrady
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Virol 85:1625-33. 2011
    ..on medoxyprogesterone treatment of female mice to render the vaginal lumen susceptible to inoculation with herpes simplex virus 2 (HSV-2)...
  100. pmc Inhibition of TANK binding kinase 1 by herpes simplex virus 1 facilitates productive infection
    Yijie Ma
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois, USA
    J Virol 86:2188-96. 2012
    The γ(1)34.5 protein of herpes simplex viruses (HSV) is essential for viral pathogenesis, where it precludes translational arrest mediated by double-stranded-RNA-dependent protein kinase (PKR)...
  101. ncbi Vaccines for herpes simplex virus infections
    David M Koelle
    University of Washington, Harborview Medical Center, Seattle 98104, USA
    Curr Opin Investig Drugs 7:136-41. 2006
    Infections with herpes simplex virus (HSV) type 1 (HSV-1) and type 2 (HSV-2) can have serious medical consequences...

Research Grants72

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..henselae, Borrelia burgdorferi, Hepatitis B Virus, Chlamydia, Plasmodium falciparum, Human papillomavirus, and Herpes simplex virus...
  2. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex virus type 1 (HSV-1) is one of the most common neurotropic pathogens in humans with a seroprevalence rate increasing up to 60-80% by the 5th decade of life...
  3. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    Viral infections caused by Herpes Simplex virus-1 (HSV-1), often occur as a result of a compromised immune system...
  4. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    ..b>Herpes Simplex Virus (HSV) infection is a chronic disease that affects over 1 billion people worldwide, with distinct disease ..
  5. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    ..model of reovirus-induced myelitis: (ii) in the brains of mice infected with West Nile Virus (WNV) and herpes simplex virus (HSV): (iii) following virus (reovirus, WNV, HSV) infection of ex vivo brain slice cultures and: (iv) in ..
  6. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..We will use female C57BL/6J mice and HSV-TK (Herpes Simplex Virus-Thymidine Kinase)-CCSP+ transgenic mice (which have gancyclovir sensitive Clara Cell Secretory Protein ..
  7. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Herpes simplex virus type-1 (HSV-1) lytic infection causes diseases ranging from simple cold sores to dangerous keratitis and lethal encephalitis...
  8. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..increase the availability of tumor antigens to the DCs, tumor cells are killed using conditional cytotoxicity [herpes simplex virus type 1 thymidine kinase (TK) plus ganciclovir (GCV)]...
  9. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    ..Using a herpes simplex virus (HSV) expressing a constitutively active I Kappa Kinase (IKKca) to activate NF?B or a dominant negative ..
  10. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..One the other hand, herpes simplex encephalitis results in rapid death in approximately 70% of cases if left untreated...
  11. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..tissues we will employ a genetically modified, Cre-dependent, transsynaptically transported reporter strain of herpes simplex virus type 1, HSV129[unreadable]TK-TT, in conjunction with available strains of reporter mice (TRPV1-Cre, ..
  12. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..by applicant): For 30 years, an effective vaccine has been sought to prevent genital herpes caused by herpes simplex virus 2 (HSV-2)...
  13. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2012
    ..2) To engineer a "sui- cide gene" strategy for purging of differentiation-resistant thal-iPSCs. An Herpes Simplex Virus-thymidine kinase (HSV-tk) "suicide gene" with regulated expression by tissue-specific promoters/..
  14. Viral And host mechanisms that tilt the HSV lytic/latent balance
    Donald M Coen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex viruses cause considerable morbidity and mortality...
  15. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..In transplant patients, herpes simplex virus (HSV) and varicella zoster virus can reactivate as disseminated life-threatening infections, HCMV causes ..
  16. Liver Cell Membrane Protein-Expression and Function
    Allan W Wolkoff; Fiscal Year: 2012
    ..microtubule-based motility of early and late endocytic vesicles as well as exocytosing vesicles that contain Herpes simplex virus and identification of vesicle-associated motors and regulatory factors;(Project 2) identification and ..
  17. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ..A similar delivery system targeting Glycoprotein D of herpes simplex type 2 will also prevent infection with that virus, which enhances transmission of HIV-1 infection...
  18. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Saul Silverstein mapping functional domains of the IE0 gene of herpes simplex virus. I then worked under Dr. E. Sander Connolly and Dr...
  19. The functions of the US3 protein kinase of herpes simplex virus
    Bernard Roizman; Fiscal Year: 2011
    This application is a continuation and replacement of a grant to study the mechanisms by which herpes simplex viruses (HSV) thwart attempts of the host cell to commit suicide (apoptosis) to block viral replication...
  20. Antifibrotic Therapy to Improve Immune reconstitution in HIV
    Timothy W Schacker; Fiscal Year: 2013
    ..increased bacterial infections, and poor control of mucosal pathogens like human papilloma virus and herpes simplex virus...
  21. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    ..Additionally the results of these studies will shed light on the dynamics of immune cell interactions during chronic viral infections such as HTLV-1, HIV-1, hepatitis virus and herpes simplex virus.
  22. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..against viral envelope N-glycoprotein synthesis (a process using LLO and likely to induce ER stress) with herpes simplex-1 as a model. The clinical relevance is two-fold...
  23. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..adenovirus vectors expressing fms-like tyrosine kinase 3 ligand (FltSL) (to recruit DCs to the brain), and herpes simplex virus type 1 thymidine kinase (HSV1-TK) that through the phosphorylation of the prodrug GCV (GCV) induces ..
  24. Molecular Biology of Eukaryotic Viruses
    Bert L Semler; Fiscal Year: 2012
    ..yeast Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis virus, SARS coronavirus, arenaviruses, herpes simplex virus, Epstein-Barr virus, human papillomavirus, vaccinia virus, and a number of RNA-containing plant viruses.
  25. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..to influenza virus vaccination after transplantation, as well as recall T cell responses to herpes zoster, herpes simplex, cytomegalovirus antigens, and tetanus toxoid...
  26. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2013
    ..2) To engineer a "suicide gene" strategy for purging of differentiation-resistant thal-iPSCs. An Herpes Simplex Virus-thymidine kinase (HSV-tk) "suicide gene" with regulated expression by tissue-specific promoters/..
  27. Targeting Nanoparticle DNA Delivery to Prostate Tumors
    Janet A Sawicki; Fiscal Year: 2010
    ..to deliver two suicide genes, a gene encoding diphtheria toxin and a fusion gene encoding cytosine deaminase + herpes simplex virus thymidine kinase to primary and metastatic prostate tumors. Our specific aims are to: 1...
  28. Development of a Novel Vaccine Against Herpes Simplex Type 2
    DEBORAH SPECTOR; Fiscal Year: 2009
    b>Herpes simplex virus type 2 (HSV-2) is a medically important pathogen worldwide, with a prevalence rate of over 20% in the US...
  29. Multilevel Targeted Therapeutics Using Surface Functionalized Nanoparticles encap
    JILL STEINBACH; Fiscal Year: 2012
    ..provided by applicant): Sexually transmitted diseases (STDs) affect 340 million new people per year, with herpes simplex virus type 2 (HSV-2) infection impacting a startling ~17 percent of U.S...
  30. Role of HSV Induced RNA Degradation in Pathogenesis
    David A Leib; Fiscal Year: 2013
    Project Summary/Abstract Herpes simplex virus (HSV) keratitis is a leading cause of non-traumatic blindness in developed countries, with more than 400,000 cases in the USA, with approximately 50,000 new and recurring cases per year...
  31. Targeting the DNA damage response pathway for the treatment of HSV esophagitis
    Oleg Alekseev; Fiscal Year: 2013
    ..b>Herpes simplex virus 1 (HSV-1) is a ubiquitous pathogen that causes a wide range of human disease, including such well-known ..
  32. Enhancing Suicide Gene Therapy Through Mechanism-Based Approaches
    Donna S Shewach; Fiscal Year: 2012
    ..We have focused on the herpes simplex virus thymidine kinase (HSV-TK), the initial activator of the antiviral drug ganciclovir (GCV) to its ..
  33. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward H Egelman; Fiscal Year: 2012
    ..The initial focus will be on Herpes Simplex Type 1 Virus (HSV-1) ICP8, but will then be extended to related viral proteins, such as from Epstein Barr ..
  34. Epigenetic regulation of viral infection and replication by periodontal bacteria
    Fengchun Ye; Fiscal Year: 2013
    ..prevalence and severity of chronic periodontitis and endure more frequent infections by herpesviruses such as herpes simplex virus (HSV), Epstein Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (KSHV)...
  35. The role of plasmacytoid dendritic cells in corneal immunity
    Pedram Hamrah; Fiscal Year: 2013
    ..that pDC are the major source of IFN-a in the cornea and play a protective role in the host defense in herpes simplex keratitis (HSK)...
  36. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Herpes simplex type 1 (HSV-1) is a common oral pathogen that causes cutaneous ulcers of the gums and oral- labia...
  37. IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..This will be accomplished by coexpressing a mutant of herpes simplex virus-1 thymidine kinase (sr39tk) with the CD19-specific CAR in T cells using the Sleeping Beauty (SB) ..
  38. Modulation of histone deacetylase activity by a gammaherpesviral kinase
    Bryan C Mounce; Fiscal Year: 2013
    ..For example, herpes simplex virus-1 (HSV-1) has evolved mechanisms to antagonize HDACs through two distinct viral proteins: ICP02 and the ..
  39. Varicella-zoster Virus: Tegument Proteins in Pathogenesis
    Ann Arvin; Fiscal Year: 2012
    ..deacetylase inhibitors, interference with nerve growth factor signaling and other triggers known to enhance herpes simplex virus reactivation. The work proposed for Yr. 1 and Yr...
  40. GENETICS OF HERPESVIRUS TRANSFORMATION
    David M Knipe; Fiscal Year: 2013
    Project Summary/Abstract The long-term goals of this research are to define 1) the mechanisms by which herpes simplex virus (HSV) remodels the host cell nucleus to optimize its replication and 2) the functions and mechanisms of action of ..
  41. CYTOTOXIC LYMPHOCYTES AND HSV-1 CORNEAL LESIONS
    Robert L Hendricks; Fiscal Year: 2013
    Reactivation of herpes simplex virus type 1 (HSV-1) from a latent state in sensory neurons and anterograde transport to the cornea appears to be a predominant cause of recurrent herpes keratitis, a blinding disease of the cornea...
  42. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    ..HSK is triggered by reactivation of herpes simplex virus type 1 (HSV-1) from a latent state that is established in sensory neurons during the primary infection...
  43. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..We additionally investigate the bioactivity of these mediators in an animal model of herpes simplex virus type-1 (HSV-1), focusing on compromised sensitivity, nerve regeneration and inflammation...
  44. Uncovering the Regulatory Role of gH/gL in HSV Fusion
    Roselyn J Eisenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex virus causes human diseases, ranging from cold sores to more serious infections, some of which can be life threatening...
  45. Varicella-Zoster Virus: T Cell/Skin Tropism &Immunity
    Ann Arvin; Fiscal Year: 2013
    ..T cell tropism is an important difference between the life cycles of VZV and herpes simplex viruses 1 and 2...
  46. Novel dominant-negative HSV-2 recombinant viral vaccines
    Feng Yao; Fiscal Year: 2011
    b>Herpes simplex virus (HSV) infections can cause significant clinical problems and even death in individuals who are immunodeficient or suffering from disorders of skin integrity...
  47. Screens for host DNA replication and repair factors involved in viral infection
    Matthew D Weitzman; Fiscal Year: 2010
    ..viral families and genomes are: the linear double-stranded DNA (dsDNA) genomes of Adenovirus (Ad) and Herpes Simplex Virus type 1 (HSV-1), the single-stranded DNA (ssDNA) genome of the parvovirus Adeno-Associated Virus (AAV), ..
  48. Prevention of VZV Reactivation
    Randall J Cohrs; Fiscal Year: 2013
    ..are detected in latently infected human ganglia, whereas all other neurotropic alphaherpesviruses, including herpes simplex-1 (HSV-1), transcribe a single latency associated transcript (LAT)...
  49. Chromatin and Herpes Simplex Virus Latency
    David M Knipe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex viruses cause considerable morbidity and mortality...
  50. Genetic analysis of Herpes virus neurotropism and encephalitis
    JENNIFER HART LAVAIL; Fiscal Year: 2011
    b>Herpes simplex virus (HSV) infections are responsible for recurrent corneal herpetic keratitis, as well as sporatic acute encephalitis...
  51. Corneal Lymphatics &Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2013
    ..Relative to herpes simplex virus type 1 (HSV-1) infection, only hemangiogenesis has been investigated...
  52. Engineering Polymers For Gene Therapy of Head Cancer
    Hamid Ghandehari; Fiscal Year: 2013
    ..Gene-directed enzyme prodrug therapy (GDEPT) using adenovirus with herpes simplex virus thymidine kinase (Ad...
  53. Retinal Iron Homeostasis in Health and Disease
    Vadivel Ganapathy; Fiscal Year: 2013
    ..and hepcidin is markedly altered in RPE and in retina as a result of infection with cytomegalovirus (CMV) and herpes simplex virus-1 (HSV1). These interesting and important findings form the basis for the proposed studies...
  54. SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANS
    Robert J Linhardt; Fiscal Year: 2012
    ..Two unusual residues, GlcN3S6S and GlcA2S, in the heparan sulfate (HS) receptor responsible for herpes simplex virus type 1 infection...
  55. Targeting the DNA Damage Response for the Treatment of Herpes Simplex Labialis
    WILLIAM DONEGAN; Fiscal Year: 2013
    b>Herpes Simplex Virus 1 (HSV-1) is a ubiquitous pathogen that exists worldwide, and has a seroprevalance of 57.7% in the United States...
  56. Genomic systems approach to measure HSV-1-specific T-cell dominance in humans
    David M Koelle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex virus type 1 (HSV-1) is a medically significant pathogen. 60% of US citizens are infected and rates are higher in developing countries...
  57. CHARACTERIZATION OF A NOVEL HOST PATHWAY THAT REGULATES CHLAMYDIAL DEVELOPMENT
    Robert V Schoborg; Fiscal Year: 2013
    ..9 billion dollars in the US in 2000. Genital Chlamydia trachomatis (2,800,000 new cases/year) and Herpes Simplex Virus type 2 (HSV-2;200- 500,000 new cases/year + <40 million currently infected) infections can cause a ..
  58. Crossing Borders: HIV and Substance use at the Gateway to North America
    Kimberly C Brouwer; Fiscal Year: 2013
    ..All will be tested for HIV, syphilis, herpes simplex virus-2, and HCV, and treated as needed...
  59. Virus-Cell Interaction Affecting HSV Gene Expression
    Neal A DeLuca; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection by herpes simplex virus type 1 (HSV-1) can result in relatively mild cutaneous lesions, and more severe outcomes such as blindness and encephalitis...
  60. Cellular dissection of herpes simplex encephalitis with iPS cells
    Jean Laurent Casanova; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes simplex encephalitis (HSE) of childhood is a life-threatening central nervous system (CNS)-specific complication of primary infection by herpes simplex virus 1 (HSV-1)...
  61. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Herpetic stromal keratitis (HSK) is a chronic inflammatory disease of the cornea caused by herpes simplex virus-1...
  62. MOLECULAR GENETICS OF HSV DNA POLYMERASE GENE
    James M Hogle; Fiscal Year: 2013
    ..Specific aim 1 is to investigate the unusual and different manners by which the accessory subunits, such as herpes simplex virus (HSV) UL42 and human cytomegalovirus (HCMV) UL44, interact with DNA so that they bind tightly, yet ..
  63. MURINE MODEL OF IMMUNOSUPPRESSION INDUCED CMV RETINITIS
    Patrick Cleveland; Fiscal Year: 1991
    ..ocular infections, including cytomegalovirus (CM), Cryptococcosis, Toxoplasmosis, Candida, Mycobacterium, herpes simplex herpes simplex virus, varicella zoster virus, histoplasmosis, and syphilis which have been reported in the ..
  64. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
    b>Herpes Simplex virus (HSV) can cause a wide range of diseases including skin lesions which are common, encephalitis which is rare, an HSV infection of the eye which is a leading cause of blindness in the USA (400,000 cases)...
  65. Ocular HSV-Latency, Reactivation, and Recurrence
    James M Hill; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Herpes simplex virus (HSV) is the leading cause of infectious blindness in the industrialized nations. In the USA, 300,000 cases are treated yearly...
  66. Genetics and Functions of HSV Membrane Fusion Proteins
    KONSTANTIN KOUSOULAS; Fiscal Year: 2009
    ..b>Herpes simplex virus type 1 (HSV-1) is a frequent cause of adult sporadic encephalitis, keratoconjunctivitis and oral ..
  67. Investigation of herpes simplex virus -1 neurotropism in SCID DRG xenografts
    Ann M Arvin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Herpes simplex virus-1 (HSV-1) is human alphaherpesvirus that establishes a lifelong latent infection in peripheral nerve ganglia following primary infection...
  68. ASSEMBLY OF THE HERPES SIMPLEX VIRUS CAPSID
    Jay Brown; Fiscal Year: 2007
    Relevance: Herpes simplex virus (HSV-1) continues to be the cause of widespread human illness despite the availabiltiy of a reasonably effective therapeutic, acyclovir, and related compounds...
  69. Innate Resistance to Mucosal HSV Infection in Humans
    Christine M Posavad; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Herpes simplex virus type 2 (HSV-2) is the major cause of genital herpes, one of the most frequent sexually transmitted diseases...
  70. Silencing Suppression Mechanism of a Herpes Simplex Virus Virion Component
    NIL CELEBI CHERUKURI; Fiscal Year: 2009
    ..The US11 protein of herpes simplex virus type l (HSV-1) is thought to have silencing suppressor activity in mammalian cells and to help the virus ..
  71. MOLECULAR CHARACTERIZATION OF HERPES SIMPLEX VIRUS ICP27
    Stephen Rice; Fiscal Year: 2003
    The infection of mammalian cells with herpes simplex virus type 1 (HSV-1) results in dramatic alterations to the host cell nucleus, so that viral genes are expressed at high levels while cellular genes are nearly completely suppressed...
  72. MOLECULAR BIOLOGY OF HERPES SIMPLEX VIRUSES
    Bernard Roizman; Fiscal Year: 2000
    b>Herpes simplex viruses (HSV), members of a family of oncogenic viruses, cause moderate to severe disease, particularly in neonates and in infection-or drug induced immunologically deficient individuals including cancer patients, and are ..