viral pneumonia

Summary

Summary: Pneumonia caused by a virus. (Dorland, 28th ed)

Top Publications

  1. ncbi Prospective study of respiratory viral infections in pediatric hemopoietic stem cell transplantation patients
    Robbert G M Bredius
    Department of Pediatrics, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Infect Dis J 23:518-22. 2004
  2. ncbi Human coronavirus infections in rural Thailand: a comprehensive study using real-time reverse-transcription polymerase chain reaction assays
    Ryan K Dare
    Respiratory and Gastroenteritis Viruses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1321-8. 2007
  3. ncbi Viral pneumonia in older adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    Clin Infect Dis 42:518-24. 2006
  4. pmc Association of normal weather periods and El Niño events with hospitalization for viral pneumonia in females: California, 1983-1998
    K L Ebi
    EPRI, 3412 Hillview Ave, Palo Alto, CA 94304, USA
    Am J Public Health 91:1200-8. 2001
  5. pmc Influenza virus infection in racing greyhounds
    Kyoung Jin Yoon
    Emerg Infect Dis 11:1974-6. 2005
  6. ncbi Non-specific host response markers in the differentiation between pneumococcal and viral pneumonia: what is the most accurate combination?
    Matti Korppi
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Pediatr Int 46:545-50. 2004
  7. ncbi Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia
    Leontine J R Van Elden
    Eijkman Winkler Institute of Medical Microbiology, Infectious Diseases and Inflammation, Department of Virology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Clin Infect Dis 34:177-83. 2002
  8. pmc Differentiation of bacterial and viral pneumonia in children
    R Virkki
    Department of Diagnostic Imaging, Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Thorax 57:438-41. 2002
  9. doi Update on avian influenza A (H5N1) virus infection in humans
    Abdel Nasser Abdel-Ghafar
    Ministry of Health and Population, Cairo
    N Engl J Med 358:261-73. 2008
  10. ncbi A role for Streptococcus pneumoniae in virus-associated pneumonia
    Shabir A Madhi
    University of the Witwatersrand Medical Research Council National Institute for Communicable Diseases Respiratory and Meningeal Pathogens Research Unit, Atlanta 30332, USA
    Nat Med 10:811-3. 2004

Detail Information

Publications238 found, 100 shown here

  1. ncbi Prospective study of respiratory viral infections in pediatric hemopoietic stem cell transplantation patients
    Robbert G M Bredius
    Department of Pediatrics, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Infect Dis J 23:518-22. 2004
    ..We performed a prospective study to assess the impact of real time PCR diagnosis as well as protective isolation for community-acquired respiratory virus infections in pediatric patients undergoing hemopoietic stem cell transplantation...
  2. ncbi Human coronavirus infections in rural Thailand: a comprehensive study using real-time reverse-transcription polymerase chain reaction assays
    Ryan K Dare
    Respiratory and Gastroenteritis Viruses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1321-8. 2007
    ..We sought to determine whether infections with human coronaviruses (HCoVs) 229E, OC43, HKU1, and NL63 are associated with pneumonia and to define the epidemiology of HCoV infection in rural Thailand...
  3. ncbi Viral pneumonia in older adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    Clin Infect Dis 42:518-24. 2006
    ..A H3N2 and respiratory syncytial virus are the most commonly identified viral pathogens in older adults with viral pneumonia. As diagnostic tests such as reverse-transcription polymerase chain reaction become more widely used, the ..
  4. pmc Association of normal weather periods and El Niño events with hospitalization for viral pneumonia in females: California, 1983-1998
    K L Ebi
    EPRI, 3412 Hillview Ave, Palo Alto, CA 94304, USA
    Am J Public Health 91:1200-8. 2001
    This study examined associations between weather and hospitalizations of females for viral pneumonia during normal weather periods and El Niño events in the California counties of Sacramento and Yolo, San Francisco and San Mateo, and ..
  5. pmc Influenza virus infection in racing greyhounds
    Kyoung Jin Yoon
    Emerg Infect Dis 11:1974-6. 2005
  6. ncbi Non-specific host response markers in the differentiation between pneumococcal and viral pneumonia: what is the most accurate combination?
    Matti Korppi
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Pediatr Int 46:545-50. 2004
    ..The aim of the present paper was to determine if there is a combination of these four host response markers and chest radiograph findings suitable for differentiating pneumococcal from viral etiology of pneumonia...
  7. ncbi Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia
    Leontine J R Van Elden
    Eijkman Winkler Institute of Medical Microbiology, Infectious Diseases and Inflammation, Department of Virology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Clin Infect Dis 34:177-83. 2002
    ....
  8. pmc Differentiation of bacterial and viral pneumonia in children
    R Virkki
    Department of Diagnostic Imaging, Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Thorax 57:438-41. 2002
    ....
  9. doi Update on avian influenza A (H5N1) virus infection in humans
    Abdel Nasser Abdel-Ghafar
    Ministry of Health and Population, Cairo
    N Engl J Med 358:261-73. 2008
  10. ncbi A role for Streptococcus pneumoniae in virus-associated pneumonia
    Shabir A Madhi
    University of the Witwatersrand Medical Research Council National Institute for Communicable Diseases Respiratory and Meningeal Pathogens Research Unit, Atlanta 30332, USA
    Nat Med 10:811-3. 2004
    ..These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia...
  11. ncbi Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life
    D James Nokes
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    J Infect Dis 190:1828-32. 2004
    ..RSV contributed significantly to total LRTI disease in this vaccine-target group...
  12. ncbi Complications of viral influenza
    Michael B Rothberg
    Division of General Medicine, Baystate Medical Center, Springfield, MA 01199, USA
    Am J Med 121:258-64. 2008
    ..During influenza season, treatment of pneumonia should include empiric coverage for this pathogen. Neuromuscular and cardiac complications are unusual but may manifest in persons of any age...
  13. pmc Reovirus infection in rat lungs as a model to study the pathogenesis of viral pneumonia
    M J Morin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 70:541-8. 1996
    ..We propose that experimental reovirus infection in the lungs can serve as a model for the pathogenesis of viral pneumonia in which pulmonary inflammation results following direct infection of lung epithelial cells.
  14. ncbi Aetiology of community-acquired pneumonia: serological results of a paediatric survey
    Massimiliano Don
    Department of Paediatrics, School of Medicine DPMSC, University of Udine, Udine, Italy
    Scand J Infect Dis 37:806-12. 2005
    ..pneumoniae at >2 y of age and emphasize the emerging role of hMPV. The high proportion of mixed viral-bacterial infections highlights the need to treat all children with CAP with antibiotics...
  15. ncbi Viral pneumoniae in children: incidence and aetiology
    C A Sinaniotis
    Second Department of Paediatrics, University of Athens School of Medicine, Athens, Greece
    Paediatr Respir Rev 5:S197-200. 2004
    ..Viral pneumonias frequently are complicated by bacterial infections and mixed infections are identified in 30% of the cases. The precise role of viruses and bacteria in these cases, remains to be clarified...
  16. ncbi Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California
    Janice K Louie
    California Department of Public Health, 850 Marina Bay Pkwy, Richmond, CA 94804, USA
    JAMA 302:1896-902. 2009
    ..Pandemic influenza A(H1N1) emerged rapidly in California in April 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A(H1N1) disproportionately affects younger ages and causes generally mild disease...
  17. ncbi Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients
    Janet A Englund
    Children s Hospital and Regional Medical Center, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98105, USA
    Ann Intern Med 144:344-9. 2006
    ..Human metapneumovirus (hMPV), a recently discovered respiratory virus, is associated with clinical disease in young and elderly persons...
  18. ncbi Serum procalcitonin concentrations in bacterial pneumonia in children: a negative result in primary healthcare settings
    Matti Korppi
    Department of Paediatrics, Kuopio University Hospital, Kuopio University, Kuopio, Finland
    Pediatr Pulmonol 35:56-61. 2003
    ..viral infection). We conclude that serum PCT measurements have no role in the diagnosis of bacterial CAP in children in primary healthcare settings...
  19. ncbi Development and validation of a clinical prediction rule to distinguish bacterial from viral pneumonia in children
    Laura Moreno
    Division of Pulmonology, Hospital de Niños de la Santísima Trinidad, Universidad Nacional de Cordoba, Cordoba, Argentina
    Pediatr Pulmonol 41:331-7. 2006
    Distinguishing bacterial from viral pneumonia on admission to the hospital could guide the decision of whether or not to use antibiotics...
  20. ncbi Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?
    Thomas C Luke
    Bureau of Medicine and Surgery, U S Navy, Washington, DC, USA
    Ann Intern Med 145:599-609. 2006
    ..Treatments for H5N1 influenza are unsatisfactory, and convalescent human plasma containing H5N1 antibodies could be an effective therapy during outbreaks and pandemics...
  21. ncbi Viral etiology of pneumonia in a cohort of newborns till 24 months of age in Rural Mirzapur, Bangladesh
    Khundkar Hasan
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    Scand J Infect Dis 38:690-5. 2006
    ..Children living in a one-room house were 3 times more likely to develop viral pneumonia (odds ratio (OR) = 3.67, CI 1.05-12.83) than children living in a larger house...
  22. ncbi Local CD11c+ MHC class II- precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process
    Hongwei Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London, United Kingdom
    J Immunol 177:2536-42. 2006
    ..This depletion of local DC precursors in respiratory viral infections may be important in explaining complex interactions between multiple and intercurrent pulmonary infections...
  23. ncbi The value of clinical features in differentiating between viral, pneumococcal and atypical bacterial pneumonia in children
    Matti Korppi
    Paediatric Research Centre, Tampere University and University Hospital, Tampere, Finland
    Acta Paediatr 97:943-7. 2008
    ..To evaluate the value of clinical features in differentiating between viral, pneumococcal and atypical bacterial pneumonia in children...
  24. ncbi Open-lung biopsy in patients with acute respiratory distress syndrome
    L Papazian
    Service de Reanimation Polyvalente, Hopital Sainte Marguerite, Marseille, France
    Anesthesiology 88:935-44. 1998
    ..The aim of this observational case series was to evaluate the safety and utility of open-lung biopsy (OLB) performed in patients receiving ventilatory support who had persistent ARDS despite negative bacterial cultures...
  25. ncbi Clinical response to antibiotic therapy for community-acquired pneumonia
    Taina Juven
    Department of Paediatrics, Turku University Hospital, PL 52, 20521, Turku, Finland
    Eur J Pediatr 163:140-4. 2004
    ..Expensive and time-consuming microbiological investigations are not required once bacterial sepsis has been excluded...
  26. ncbi Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico
    Rogelio Perez-Padilla
    National Institute of Respiratory Diseases, Mexico City, Mexico
    N Engl J Med 361:680-9. 2009
    ....
  27. ncbi Mixed microbial aetiology of community-acquired pneumonia in children
    Matti Korppi
    Department of Paediatrics, Kuopio University Hospital, Finland
    APMIS 110:515-22. 2002
    ..Current guidelines recommend antibiotic therapy for all community-acquired pneumonia cases in children...
  28. ncbi Controls for lung dendritic cell maturation and migration during respiratory viral infection
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:1438-48. 2007
    ..Our results indicate that pDCs and cDCs respond distinctly to respiratory paramyxoviral infection with patterns of movement that should serve to coordinate the innate and adaptive immune responses, respectively...
  29. ncbi Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections
    M N Tsolia
    Second Department of Pediatrics, University of Athens School of Medicine, P and A Kyriakou Children s Hospital, Athens, Greece
    Clin Infect Dis 39:681-6. 2004
    ..Community-acquired pneumonia (CAP) in young children is most commonly associated with viral infections; however, the role of viruses in CAP of school-age children is still inconclusive...
  30. pmc 8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis
    Takaaki Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 100:685-90. 2003
    ..The present data constitute a demonstration of 8-nitroguanosine formation in vivo and suggest a potential role for NO-induced nitrative stress in viral pathogenesis...
  31. pmc Clinical review: primary influenza viral pneumonia
    Jordi Rello
    Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Tarragona, Spain
    Crit Care 13:235. 2009
    ..Ensuring an appropriate oxygenation and ventilation strategy, as well as prompt initiation of antiviral therapy, is essential in management...
  32. ncbi Clinical significance of herpes simplex virus in the lower respiratory tract of critically ill patients
    K Camps
    Department of Microbiology, University Hospital of Antwerp, Wilrijkstraat 10, Edegem, Belgium
    Eur J Clin Microbiol Infect Dis 21:758-9. 2002
  33. ncbi Histone acetylation and deacetylation: importance in inflammatory lung diseases
    P J Barnes
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Eur Respir J 25:552-63. 2005
    ..The reduction in histone deacetylase activity can be restored by theophylline, which may be able to reverse steroid resistance in chronic obstructive pulmonary disease and other inflammatory diseases...
  34. ncbi Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children
    Ian C Michelow
    Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Pediatrics 113:701-7. 2004
    ..The objective of this study was to determine as precisely as possible the epidemiology and morbidity of community-acquired pneumonia in hospitalized children...
  35. ncbi Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index
    Mar Masia
    Infectious Diseases Unit, Internal Medicine Department, Hospital General Universitario de Elche, Camí de la Almazara S N 03203 ELCHE, Alicante, Spain
    Chest 128:2223-9. 2005
    ..To evaluate the usefulness of procalcitonin serum levels as a predictor of etiology and prognosis in adult patients with community-acquired pneumonia (CAP) when they are stratified according to severity...
  36. pmc Procalcitonin in children admitted to hospital with community acquired pneumonia
    F Moulin
    Department of Pediatrics, , 82 Av Denfert-Rochereau, 75014 Paris, France
    Arch Dis Child 84:332-6. 2001
    ..1 microg/l in 86% of patients with bacterial infection (including Mycoplasma and bacterial superinfection of viral pneumonia)...
  37. ncbi Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children
    P Toikka
    Department of Pediatrics, Turku University Hospital, Finland
    Pediatr Infect Dis J 19:598-602. 2000
    ..IL-6) concentrations were measured in 126 children hospitalized for community-acquired, radiologically confirmed pneumonia to assess whether these host response values could be used to distinguish bacterial from viral pneumonia.
  38. ncbi Influenza A pneumonia with rhabdomyolysis
    S E Morton
    Veterans Affairs Medical Center, Mountain Home, Tenn, USA
    South Med J 94:67-9. 2001
    ....
  39. ncbi Viral pneumonia: epidemiological, clinical, pathophysiological and therapeutic aspects
    Luiz Tadeu Moraes Figueiredo
    Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    J Bras Pneumol 35:899-906. 2009
    ..These types of pneumonia are commonly caused by influenza A and B; parainfluenza 1, 2 and 3; respiratory syncytial virus; or adenovirus. We also address the types of pneumonia caused by hantaviruses, metapneumoviruses and rhinoviruses...
  40. ncbi Human metapneumovirus pneumonia in children: results of an Italian study and mini-review
    Massimiliano Don
    Paediatric Department, School of Medicine, DPMSC, University of Udine, Italy
    Scand J Infect Dis 40:821-6. 2008
    ..The figure was about 5% in the present and in the only earlier paediatric CAP study. Thus, hMPV is a real but rare cause of paediatric CAP, although seroconversion to hMPV in most children takes place in early childhood...
  41. pmc Identification of adenovirus, influenza virus, parainfluenza virus, and respiratory syncytial virus by two kinds of multiplex polymerase chain reaction (PCR) and a shell vial culture in pediatric patients with viral pneumonia
    Jong Han Lee
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    Yonsei Med J 51:761-7. 2010
    ..Two kinds of multiplex polymerase chain reaction (PCR) and a commercial shell vial viral culture were performed to identify causative agents in pediatric patients...
  42. ncbi Viral community-acquired pneumonia in nonimmunocompromised adults
    Andres De Roux
    Servei de Pneumologia, Institut Clinic de Pneumologia i Cirurgia Toracica, Barcelona, Spain
    Chest 125:1343-51. 2004
    ..Viral community-acquired pneumonia (CAP) has been poorly studied and clinically characterized. Using strict criteria for inclusion, we studied this type of infection in a large series of hospitalized adults with CAP...
  43. ncbi Incidence and clinical features of hospitalization because of respiratory syncytial virus lower respiratory illness among children less than two years of age in a rural Asian setting
    I G Djelantik
    Program for Appropriate Technology in Health, Seattle WA, USA
    Pediatr Infect Dis J 22:150-7. 2003
    ..Despite this few reports on respiratory syncytial virus (RSV) lower respiratory illness disease burden exist from rural areas of the developing world, and none exist for Indonesia...
  44. ncbi H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion.
  45. ncbi Viral pneumonia
    Maria Angeles Marcos
    Department of Microbiology, Hospital Clinic i Provincial de Barcelona, Spain
    Curr Opin Infect Dis 22:143-7. 2009
    ..The purpose of the present article is to review several issues of viral infection in CAP in light of recent studies that included exhaustive evaluation of viruses...
  46. ncbi Evaluation by survival analysis on effect of traditional Chinese medicine in treating children with respiratory syncytial viral pneumonia of phlegm-heat blocking Fei syndrome
    Yan Yang
    Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China
    Chin J Integr Med 15:95-100. 2009
    To objectively evaluate the clinical effect of traditional Chinese medicine in treating children's respiratory syncytial viral pneumonia (RSVP) of phlegm-heat blocking Fei syndrome (PHBFS).
  47. ncbi Viral pneumonia after hematopoietic stem cell transplantation: high-resolution CT findings
    Jeffrey P Kanne
    Department of Radiology, Vancouver General Hospital, Vancouver BC, Canada
    J Thorac Imaging 22:292-9. 2007
    ..Findings of viral pneumonia on HRCT include small poorly defined centrilobular nodules and patchy, often bilateral, areas of ..
  48. ncbi Viral pneumonia as a serious complication of etanercept therapy
    Davey Smith
    Ann Intern Med 136:174. 2002
  49. ncbi Medical treatment of viral pneumonia including SARS in immunocompetent adult
    V C C Cheng
    Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Infect 49:262-73. 2004
    Since no randomized controlled trials have been conducted on the treatment of viral pneumonia by antivirals or immunomodulators in immunocompetent adults, a review of such anecdotal experience are needed for the more rational use of such ..
  50. ncbi Diagnostic value of bronchoalveolar lavage in community-acquired pneumonia in a routine setting: a study on patients treated in a Finnish university hospital
    Ulla Hohenthal
    Department of Medicine, Turku University Central Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Scand J Infect Dis 36:198-203. 2004
    ..In a subgroup of slowly responding pneumonia, the procedure was of some usefulness even after commencement of antimicrobial treatment...
  51. ncbi Cytomegalovirus pneumonia in transplant recipients
    Michael G Ison
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Chest Med 26:691-705, viii. 2005
    ..Invasive procedures are often required for the optimal management of such infections. The use of sensitive and quantitative assays have greatly improved the outcomes of CMV infection...
  52. pmc Comparison of corticosteroids for treatment of respiratory syncytial virus bronchiolitis and pneumonia in cotton rats
    Martin G Ottolini
    Department of Pediatric, F Edward Hébert School of Medicine of the Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Antimicrob Agents Chemother 46:2299-302. 2002
    ..Triamcinolone and methylprednisolone proved to be more effective than dexamethasone in reducing lung pathology. No recurrence of viral replication or pulmonary pathology followed the cessation of therapy...
  53. ncbi Respiratory syncytial virus infection in 406 hospitalized premature infants: results from a prospective German multicentre database
    Arne Simon
    Department of Pediatric Hematology and Oncology, Children s Hospital Medical Center, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    Eur J Pediatr 166:1273-83. 2007
    ..From the perspective of our results, the statements of the German Society of Paediatric Infectious Diseases considering the use of passive immunisation (2003) seem reasonable...
  54. ncbi Signs and symptoms indicative of community-acquired pneumonia in infants under six months
    Maria de Fatima Bazhuni Pombo March
    Martagão Gesteira Pediatric Institute, Dept of Pediatrics, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Braz J Infect Dis 9:150-5. 2005
    Evaluation of the clinical signs and symptoms predicting bacterial and viral pneumonia, in accordance with the Brazilian National Control Program for Acute Respiratory (ARI).
  55. ncbi Etiologic agents and outcome determinants of community-acquired pneumonia in urban children: a hospital-based study
    Abdul Wahab B R Johnson
    Department of Pediatrics, University College Hospital, Ibadan, Nigeria
    J Natl Med Assoc 100:370-85. 2008
    ....
  56. ncbi Radiological findings in children with acute pneumonia: age more important than infectious agent
    H Wahlgren
    Department of Pediatric Radiology, Astrid Lindgren s Children s Hospital, Karolinska Hospital, Stockholm, Sweden
    Acta Radiol 46:431-6. 2005
    ..To evaluate whether radiological findings and healing time in children with pneumonia are correlated to etiologic agent...
  57. ncbi Pneumonia in pregnancy
    William H Goodnight
    Division of Maternal Fetal Medicine, Medical University of South Carolina, Charleston, SC, USA
    Crit Care Med 33:S390-7. 2005
    ..This review will identify maternal risk factors, potential complications, and prenatal outcomes associated with pneumonia and describe the contemporary management of the varied causes of pneumonia in pregnancy...
  58. ncbi Invasive pulmonary aspergillosis: frequency and meaning of the "hypodense sign" on unenhanced CT
    M Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076 Tubingen
    Br J Radiol 78:697-703. 2005
    ..The hypodense sign is recognizable also on unenhanced CT, when a narrower lung window setting is used...
  59. ncbi Population-based incidence of severe pneumonia in children in Kiel, Germany
    J A Weigl
    Pediatric Infectious Diseases, Department of General Pediatrics, Christian Albrechts University
    Klin Padiatr 217:211-9. 2005
    ..Elaborated data on the descriptive epidemiology of community-acquired pneumonia (CAP) are a prerequisite to estimate the impact of new vaccines...
  60. ncbi Community-acquired pneumonia in children
    Constantine A Sinaniotis
    Second Department of Pediatrics, University of Athens School of Medicine, Laiko General Hospital, Athens, Greece
    Curr Opin Pulm Med 11:218-25. 2005
    ..This review highlights recent developments in the diagnosis, etiology, therapy, and prevention of community-acquired pneumonia in children...
  61. ncbi The correct approach to community-acquired pneumonia in immunocompetent adults: review of current guidelines
    Sergio Carbonara
    Clinic of Infectious Diseases, University of Bari, Italy
    New Microbiol 31:1-18. 2008
    ..Herein, the authors review and discuss some of the main current guidelines for CAP management, highlighting their differences and similarities...
  62. ncbi [Respiratory viruses: the most common, the most often overlooked]
    Francisco López-Medrano
    Enferm Infecc Microbiol Clin 26:67-8. 2008
  63. ncbi Defining pneumonia in critically ill infants and children
    Joanne M Langley
    Clinical Trials Research Centre, IWK Health Center, and the Department of Pediatrics, Dalhousie University, Halifax, Canada
    Pediatr Crit Care Med 6:S9-S13. 2005
    ....
  64. ncbi Viruses in community-acquired pneumonia in children aged less than 3 years old: High rate of viral coinfection
    Gustavo Cilla
    Microbiology Department, Hospital Donostia, San Sebastian, Spain
    J Med Virol 80:1843-9. 2008
    ..It is concluded that viral coinfections are frequent in children aged less than 3 years old with community-acquired pneumonia and can be a poor prognostic factor...
  65. ncbi The burden of pneumonia in children in the developed world
    Talal Farha
    The John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK
    Paediatr Respir Rev 6:76-82. 2005
    ..This does not include family and social costs. There is potential for new vaccine strategies to decrease childhood pneumonia...
  66. ncbi Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain
    Cristina Calvo
    Pediatrics Department, Severo Ochoa Hospital, Virology Service ISCIII National Microbiology Center, Madrid, Spain
    Pediatr Infect Dis J 26:904-8. 2007
    ..Our aim was to describe rhinovirus infections in hospitalized children, under 2 years of age, and to compare these with patients infected with respiratory syncytial virus (RSV)...
  67. ncbi Evaluation of chronic infectious interstitial pulmonary disease in children by low-dose CT-guided transthoracic lung biopsy
    Christoph M Heyer
    Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine, BG Clinics Bergmannsheil, Ruhr University of Bochum, Germany
    Eur Radiol 15:1289-95. 2005
    ..Open lung biopsy is an invasive procedure with major potential complications. Transthoracic lung biopsy (TLB) guided by computed tomography (CT) is a less-invasive well-established procedure in adults...
  68. ncbi The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country
    Cristiana M Nascimento-Carvalho
    Department of Pediatrics, Federal University of Bahia School of Medicine, Salvador, Brazil
    Pediatr Infect Dis J 27:939-41. 2008
    ..Rhinovirus (21%) and Streptococcus pneumoniae (21%) were the most common pathogens. Our results demonstrate the importance of viral and pneumococcal infections among those patients...
  69. ncbi Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients
    Minh L Doan
    Department of Pediatrics, Section of Pulmonology, Congenital Heart Surgery Service, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    J Heart Lung Transplant 26:883-9. 2007
    ..Cidofovir allows for directed therapy but can result in nephrotoxicity. We report our experience with cidofovir for the treatment of adenovirus pneumonia in pediatric lung transplant recipients...
  70. ncbi [Current news about epidemiology of syncytial respiratory virus infection]
    Emilio Palumbo
    Recenti Prog Med 99:237-9. 2008
    ..In these patients, the prophylaxis with palivizumab is very important to prevent chronic pulmonary diseases...
  71. ncbi A population-based assessment of the disease burden of consolidated pneumonia in hospitalized children under five years of age
    Maria Hortal
    Ministry of Health, Maternal and Child Health Program, Bv Artigas 1550, Montevideo 11600, Uruguay
    Int J Infect Dis 11:273-7. 2007
    ..Therefore, our study aimed to estimate the burden of pneumonia in hospitalized children...
  72. ncbi Influenza A community-acquired pneumonia in East London infants and young children
    Matthew Laundy
    Department of Child Health, Barts and the London Hospital NHS, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Pediatr Infect Dis J 22:S223-7. 2003
    ..The aim of this study was to determine the relative contributions of different etiologic agents to CAP in children...
  73. ncbi Pulmonary dysfunction in pediatric hematopoietic stem cell transplant patients: overview, diagnostic considerations, and infectious complications
    J Michael Collaco
    Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    Pediatr Blood Cancer 49:117-26. 2007
    ....
  74. ncbi [Pneumonia - pathogen-based or constellation-based therapy?]
    A Kuhnke
    Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13 353 Berlin
    Internist (Berl) 47:S14-9. 2006
    ..These factors must be considered at the beginning of any treatment. Pathogen-based treatment has to be switched to constellation-based treatment...
  75. ncbi Antibiotics in childhood pneumonia
    Katherine A Hale
    Department of Allergy, The Children s Hospital at Westmead, Australia
    Paediatr Respir Rev 7:145-51. 2006
    ..The route and duration of antibiotic therapy, the role of emerging pathogens and the impact of pneumococcal resistance and conjugate pneumococcal vaccines are also discussed...
  76. ncbi Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109 1024, USA
    J Infect Dis 193:1619-25. 2006
    ..Thus, community respiratory virus-associated airflow decline seems to be specific to viral species and infection localization...
  77. ncbi Mixed community-acquired pneumonia in hospitalised patients
    A de Roux
    Servei de Pneumologia i Allergia Respiratoria, Institut Clinic del Torax, Facultad de Medicina, Universitat de Barcelona, and Servei de Malalties Infeccioses, Hospital Clinic i Provincial de Barcelona, Spain
    Eur Respir J 27:795-800. 2006
    ..In conclusion, mixed pneumonia occurs in >10% of cases with community-acquired pneumonia requiring hospitalisation...
  78. ncbi Decline in respiratory syncytial virus hospitalizations in a region with high hospitalization rates and prolonged season
    Rosalyn J Singleton
    Alaska Native Tribal Health Consortium, Anchorage, AK, USA
    Pediatr Infect Dis J 25:1116-22. 2006
    ..S. general infant population rate. We describe trends in lower respiratory tract infection (LRTI) and RSV hospitalizations in YK children from 1994 to 2004...
  79. ncbi A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients
    Laurent Papazian
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:755-62. 2007
    ..The aim of this study was therefore to determine the rate of contributive open-lung biopsy and whether it improved the prognosis of ARDS patients...
  80. ncbi Effective treatment strategies for paediatric community-acquired pneumonia
    Maria Atkinson
    Nottingham University Hospitals NHS Trust, Nottingham, UK
    Expert Opin Pharmacother 8:1091-101. 2007
    ..This review describes the difficulties encountered in diagnosing community-acquired pneumonia, aetiology, treatment strategies with recommendations and highlights areas for further research...
  81. ncbi Evaluation of a nested-PCR assay for Streptococcus pneumoniae detection in pediatric patients with community-acquired pneumonia
    C Mayoral
    Sección Bacteriología, Practica Profesional, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Av Freyre 2150 3000 Santa Fe, Argentina
    Rev Argent Microbiol 37:184-8. 2005
    ..The application of the strategy described in this paper substantially seems to improve the diagnostic process in a determinate group: blood culture-negative children with pneumonia...
  82. ncbi Hyper- and hypoglycemia in children with community-acquired pneumonia
    Massimiliano Don
    Pediatric Department, School of Medicine, DPMSC, University ofUdine, Italy
    J Pediatr Endocrinol Metab 21:657-64. 2008
    ..However, about 4% of the patients had hypoglycemia, which could be explained by reduced calorie intake during acute infection or by the effect of stress-induced cytokines...
  83. ncbi [Histopathological findings of pulmonary complications in 16 patients who received allogeneic hematopoietic stem cell transplants]
    Hiroatsu Iida
    Department of Hematology, Meitetsu Hospital
    Rinsho Ketsueki 46:1273-8. 2005
    ..Efforts to reduce RRT such as using a reduced intensity regimen and careful tapering off of immunosupressants are expected to lead to a decrease in non-infectious pulmonary complications...
  84. ncbi CT findings in immunocompromised patients with pulmonary infections
    Figen Başaran Demirkazik
    Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey
    Diagn Interv Radiol 14:75-82. 2008
    ..To evaluate computed tomography (CT) findings of pulmonary infections in immunocompromised patients with hematologic malignancies, and to detect the accuracy of first-choice diagnoses...
  85. ncbi Fiberoptic bronchoscopy and bronchoalveolar lavage for the evaluation of pulmonary disease in children with primary immunodeficiency and cancer
    O Efrati
    Pediatric Pulmonology Unit, Safra Children s Hospital, The Sheba Medical Center, Tel Hashomer, affiliated to the Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Pediatr Blood Cancer 48:324-9. 2007
    ..A definite diagnosis may be achieved in these situations by fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL)...
  86. ncbi [Bronchopulmonary infections in the enfant and the child]
    Christophe Marguet
    Unité de pneumologie et allergologie pédiatrique, centre de ressource et de compétence mixte pour la mucoviscidose, Departement de Pediatrie, Centre Hospitalier Universitaire de Rouen, Hopital Charles Nicolle, 76031 Rouen
    Rev Prat 57:1237-44. 2007
  87. ncbi Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 85:278-87. 2006
    ..HSCT recipients and patients with hematologic malignancies who develop upper respiratory infection due to CRVs should be considered for antiviral therapy of proven efficacy to reduce the risk of pneumonia and death...
  88. ncbi Impact of HIV on childhood respiratory illness: differences between developing and developed countries
    S M Graham
    Malawi Liverpool Wellcome Trust Clinical Research Programme and Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi
    Pediatr Pulmonol 36:462-8. 2003
    ..Autopsy studies have provided a lot of useful data, but more prospective clinical and intervention studies from different parts of the region are needed in order to improve clinical diagnosis and management...
  89. ncbi Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections
    Kevin Purcell
    Texas A and M University Kingsville School of Pharmacy, Kingsville, Texas, USA
    Arch Pediatr Adolesc Med 156:322-4. 2002
    ..Physicians were concerned about the possibility of concurrent serious bacterial infections, especially in infants younger than 3 months and in those with infiltrates present on the chest x-ray films...
  90. ncbi Reappraisal of lung tap: review of an old method for better etiologic diagnosis of childhood pneumonia
    E Vuori-Holopainen
    Helsinki University Central Hospital, Hospital for Children and Adolescents, FIN-00029 Helsinki, Finland
    Clin Infect Dis 32:715-26. 2001
    ....
  91. ncbi Etiological agents of lower respiratory tract infections in Japanese children
    Kei Numazaki
    Research Group of Hokkaido for Pediatric Respiratory Tract Infections, Department of Pediatrics, Sapporo Medical University School of Medicine, Japan
    In Vivo 18:67-71. 2004
    ..The importance of M. pneumoniae and RS virus in the etiology of lower respiratory infections in Japanese children was confirmed...
  92. ncbi Lower respiratory tract infection in hospitalized children
    Chong Chia Yin
    Department of Paediatric Medicine, KK Women s and Children s Hospital, Republic of Singapore
    Respirology 8:83-9. 2003
    ..The aim of the present study was to investigate the aetiology and antibiotic-resistance patterns of community-acquired lower respiratory tract infection (LRTI) in 1999 and compare it with data from 1995 and 1988...
  93. ncbi An outbreak of respiratory syncytial virus infection in a bone marrow transplant unit: effect on engraftment and outcome of pneumonia without specific antiviral treatment
    A Abdallah
    Department of Clinical Haematology and Bone Marrow Transplantation Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
    Bone Marrow Transplant 32:195-203. 2003
    ..Furthermore, RSV infection in the pre-engraftment period after autologous transplantation was associated with delayed engraftment...
  94. ncbi [Seropositivity against atypical pneumonia agents demonstrated in patients with community-acquired pneumonia]
    Murat Sayan
    Dokuz Eylul Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Izmir
    Mikrobiyol Bul 37:247-53. 2003
    ..029). Since the type of the pathogens causing CAP are of crucial importance both for the epidemiological purposes and for planning the empirical treatment strategies, more detailed multicenter studies should be performed in our country...
  95. ncbi [Respiratory syncytial virus infection and asthma]
    M A Martin Mateos
    Servicio de Inmunología y Alergia, Unidad integrada de Pediatria, Hospital Clínico Hospital San Juan de Dios, Universidad de Barcelona
    Allergol Immunopathol (Madr) 29:140-6. 2001
    ..Serious forms of bronchiolitis due to RSV are more frequent in atopic individuals. The appearance of extrinsic asthma is more frequent in children who have previously had RSV bronchiolitis than in those who have not...
  96. ncbi Community-acquired pneumonia in infants and children
    Michael Ostapchuk
    Department of Family and Geriatric Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am Fam Physician 70:899-908. 2004
    ..Childhood immunization has helped decrease the incidence of invasive Haemophilus influenzae type B infection, and the newly introduced heptavalent pneumococcal vaccine may do the same for Streptococcus pneumoniae infections...
  97. ncbi Editorial overview: Infectious diseases
    Alimuddin I Zumla
    Curr Opin Pulm Med 9:163-5. 2003
  98. ncbi The discriminative value of C-reactive protein levels in distinguishing between community-acquired bacteraemic and respiratory virus-associated lower respiratory tract infections in HIV-1-infected and -uninfected children
    Sanjay G Lala
    Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa
    Ann Trop Paediatr 22:271-9. 2002
    ....
  99. ncbi Detection of human influenza virus in Yucatan, Mexico
    Guadalupe Ayora-Talavera
    Laboratorio de Hematologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan
    Rev Invest Clin 54:410-4. 2002
    ....
  100. ncbi Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia
    Charles B Stephensen
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, USA
    Am J Clin Nutr 76:1351-7. 2002
    ..The relative-dose-response (RDR) test is used to identify subjects with marginal liver vitamin A stores, but its use has not been evaluated during episodes of infection...
  101. ncbi [Various sides of influenza, part I--structure, replication, changeability of influenza viruses, clinical course of the disease, immunological response and laboratory diagnostics]
    Magdałena K Machała
    Krajowy Ośrodek ds Grypy, Samodzielna Pracownia ds Grypy, Paistwowy Zakład Higieny w Warszawte
    Pol Merkur Lekarski 21:270-6. 2006
    ..Reasons for the severe course of the disease or even death are post-influenza complications, e.g. viral pneumonia and bronchitis, bronchiolitis in children, secondary bacterial pneumonia, otitis media, myocarditis and ..

Research Grants35

  1. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..etiology and outcomes of pediatric influenza-associated pneumonia in Salt Lake County, including primary viral pneumonia, viral and bacterial co-infection, and post-influenza bacterial pneumonia...
  2. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Human respiratory syncytial virus (hRSV), an RNA virus, is the leading cause of viral pneumonia, bronchiolitis, respiratory failure, mechanical ventilation, and viral death in infants in the USA and ..
  3. Mucosal Immune Barrier in Infection and Immunity
    Keith E Mostov; Fiscal Year: 2012
    ..Mucosal infections include bacterial and viral pneumonia, SARS, TB, AIDS and other sexually transmitted diseases, numerous opportunistic, emerging and re-emerging ..
  4. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2013
    ..etiology, and outcomes of pediatric influenza-associated pneumonia in Salt Lake County, including primary viral pneumonia, viral and bacterial co-infection, and post-influenza bacterial pneumonia...
  5. Structural studies of respiratory syncytial virus
    Elizabeth R Wright; Fiscal Year: 2013
    ..To answer these questions, we are using the A2 strain of RSV that causes bronchiolitis, viral pneumonia, and death in young children, the elderly, and immuno-compromised individuals...
  6. MicroRNA biology and the host response to influenza virus infection
    Jasmine T Perez; Fiscal Year: 2010
    ..infection;it results in respiratory disease ranging from subclinical symptoms to life-threatening primary viral pneumonia. Despite the availability of a yearly vaccine, it is estimated that an average of 360,000 deaths/year can be ..
  7. Inflammatory Response and SARS Pathogenesis: An in vitro Model
    CHIEN TE TSENG; Fiscal Year: 2009
    ..Because SARS is considered a viral pneumonia, likely caused by unregulated and often excess innate inflammatory responses, a full understanding is ..
  8. PATHOBIOCHEMISTRY OF ACUTE LUNG INJURY
    John Hoidal; Fiscal Year: 2000
    ..expression in mice and to evaluate effects of this manipulation in clinically relevant models of lung injury (Viral Pneumonia, reperfusion injury and sepsis)...
  9. COLLECTINS AND LUNG DEFENSE
    Ann Marie LeVine; Fiscal Year: 2003
    ..Such data may be useful in the future in designing treatment and prevention of viral pneumonia in susceptible patients...
  10. POLYNUCLEOTIDE VACCINES FOR SIV INFECTION AND DISEASE
    Robert Malone; Fiscal Year: 2000
    ..and hence is focused on the development of such vaccines for prevention of lentiviral disease and acute viral pneumonia. Genetic immunization (DNA vaccination) and cytokine augmentation of antiviral immune responses are novel ..
  11. DENDRITIC CELLS, RSV AND INFLUENZA INFECTION IN CHILDREN
    Octavio Ramilo; Fiscal Year: 2005
    Respiratory syncytial virus (RSV) is the principal etiologic agent of bronchiolitis and viral pneumonia in infants and young children worldwide. Influenza viruses also contribute to significant number of hospitalizations among children...
  12. Mechanisms of Respiratory Syncytial Virus-Induced Mucus" Viral Strain Dependence
    MARTIN LAWRENCE MOORE; Fiscal Year: 2010
    ..causes >100,000 infant hospitalizations in the US each year and is the leading cause of bronchiolitis and viral pneumonia in infants...
  13. HOST DEFENSE AGAINST INFLUENZA
    PARKER SMALL; Fiscal Year: 1990
    ..to separate considerations of prevention and recovery as well as considerations of rhinotracheitis and viral pneumonia. Serum antibody mediates prevention of viral pneumonia, but not rhinotracheitis...
  14. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  15. CCSP IN INNATE DEFENSE AGAINST LUNG VIRAL INFECTION
    KEVIN HARROD; Fiscal Year: 2003
    ..This application will determine the role and delineate mechanisms by which CCSP provides innate immunity to viral infection in the lung. Such data may be useful in designing treatment and prevention of viral pneumonia.
  16. Pivotal role of VLA-1 in CD8 T cell retention & survival
    David Topham; Fiscal Year: 2007
    ..We will also test the prediction that the VLA-1+ memory T cells are functionally distinct and important for secondary immune protection. [unreadable] [unreadable]..
  17. Mucosal RSV vaccine using CpG oligodeoxynucleotides
    Gregory Prince; Fiscal Year: 2003
    ..Phase II activities would use that information to formulate a vaccine that would be both effective and safe. ..
  18. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter C Doherty; Fiscal Year: 2010
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
  19. Reducing Transmission of Influenza by Face Masks
    ARNOLD MONTO; Fiscal Year: 2008
    ..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
  20. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  21. A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA
    Francisco Rosales; Fiscal Year: 2005
    ..In addition, the application of these methods and the development of a model of chronic inflammation will foster research on other micronutrients like iron and zinc that are similarly affected by inflammation. ..
  22. IMPROVEMENT OF THE COTTON RAT MODEL OF HUMAN DISEASES
    Gregory Prince; Fiscal Year: 2002
    ..The proposed workscope of this application is to develop a library of reagents directed against cotton rat cell-surface antigens, cytokines and chemokines. ..
  23. Genotypes of Helicobacter Pylori in West Africa
    Richard Adegbola; Fiscal Year: 2005
    ..pylori colonization in West Africa differ from those seen in industrialized nations, and enable the development of appropriate treatment strategies for communities such as The Gambia. ..
  24. HAEMOPHILUS ANTIGEN REGULATION OF INFLAMMATION IN COPD
    Sanjay Sethi; Fiscal Year: 2003
    ..Identification of the integral bacterial and host components that contribute to immune-mediated inflammation in COPD will ultimately lead to novel therapeutic strategies to alter disease progression and improve outcome in COPD. ..
  25. Comparative Study of Influenza Vaccines in Adults
    ARNOLD MONTO; Fiscal Year: 2006
    ..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
  26. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  27. Interaction of MHV RNA with mtHSP70 and m-aconitase
    Julian Leibowitz; Fiscal Year: 2007
    ..The functional significance of the interaction of mtHSP70, m-aconitase, HSP60, and HSP40 with MHV RNA on virus replication will be examined in a series of experiments employing mutational and over-expression strategies. ..
  28. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  29. Genetic Determinants of A. Fumigatus Susceptibility
    Aimee Zaas; Fiscal Year: 2008
    ..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..
  30. Regulation of the P13K/AKT pathway in Waldenstrom Macroglobulinemia
    Irene Ghobrial; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Novel Model to Predict Safety and Efficacy of Microbicides
    Gregory Prince; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
    ..abstract_text> ..
  33. Innate Immunity and exacerbations of COPD
    Sanjay Sethi; Fiscal Year: 2009
    ..The overall goal of this research is to identify specific aspects of the innate defense of the lung that determine the frequency of exacerbations in COPD that will serve as potential therapeutic targets to reduce exacerbations. ..