viral bronchiolitis

Summary

Summary: An acute inflammatory disease of the upper RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.

Top Publications

  1. ncbi Immunological mechanisms of severe respiratory syncytial virus bronchiolitis
    Louis Bont
    Wilhelmina Children s Hospital, University Medical Center, POB 85090, 3508 AB Utrecht, The Netherlands
    Intensive Care Med 28:616-21. 2002
  2. ncbi Acute viral bronchiolitis: to treat or not to treat-that is the question
    Claudia Calogero
    J Pediatr 151:235-7. 2007
  3. ncbi T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis
    Virginia Amanatidou
    Laboratory of Clinical Virology, Medical School, University of Crete, Greece
    Pediatr Infect Dis J 25:410-4. 2006
  4. ncbi The role of the respiratory syncytial virus in airway syndromes in childhood
    Mark L Everard
    Department of Respiratory Medicine, Sheffield Children s Hospital, Western Bank, Sheffield, UK
    Curr Allergy Asthma Rep 6:97-102. 2006
  5. pmc Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis
    A Mandelberg
    Pediatric Pulmonary Unit, Pediatric Department, Pediatric Critical Care Unit, The Edith Wolfson Medical Centre, Holon, Israel
    Clin Exp Immunol 144:48-52. 2006
  6. ncbi Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7
    N Sigurs
    Department of Pediatrics, Borås Central Hospital, Boras, Sweden
    Am J Respir Crit Care Med 161:1501-7. 2000
  7. ncbi Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
    Malcolm G Semple
    Department of Child Health, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:382-6. 2005
  8. ncbi Nasal continuous positive airway pressure decreases respiratory muscles overload in young infants with severe acute viral bronchiolitis
    Gilles Cambonie
    Pediatric Intensive Care Unit, CHU Montpellier, 34000 Montpellier, France
    Intensive Care Med 34:1865-72. 2008
  9. ncbi Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, NY 13210 2375, USA
    Virology 349:87-95. 2006
  10. pmc Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis
    Avraham Beigelman
    Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St, Louis, MO USA
    Respir Res 11:90. 2010

Detail Information

Publications172 found, 100 shown here

  1. ncbi Immunological mechanisms of severe respiratory syncytial virus bronchiolitis
    Louis Bont
    Wilhelmina Children s Hospital, University Medical Center, POB 85090, 3508 AB Utrecht, The Netherlands
    Intensive Care Med 28:616-21. 2002
    ....
  2. ncbi Acute viral bronchiolitis: to treat or not to treat-that is the question
    Claudia Calogero
    J Pediatr 151:235-7. 2007
  3. ncbi T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis
    Virginia Amanatidou
    Laboratory of Clinical Virology, Medical School, University of Crete, Greece
    Pediatr Infect Dis J 25:410-4. 2006
    ....
  4. ncbi The role of the respiratory syncytial virus in airway syndromes in childhood
    Mark L Everard
    Department of Respiratory Medicine, Sheffield Children s Hospital, Western Bank, Sheffield, UK
    Curr Allergy Asthma Rep 6:97-102. 2006
    ..The phenotype of the acute illness probably provides better prognostic information than the type of virus...
  5. pmc Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis
    A Mandelberg
    Pediatric Pulmonary Unit, Pediatric Department, Pediatric Critical Care Unit, The Edith Wolfson Medical Centre, Holon, Israel
    Clin Exp Immunol 144:48-52. 2006
    ..A certain threshold of LPS hyporesponsiveness may have a very high negative predictive value for ICU hospitalization, even better than the determination of known TLR4 mutations for this purpose...
  6. ncbi Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7
    N Sigurs
    Department of Pediatrics, Borås Central Hospital, Boras, Sweden
    Am J Respir Crit Care Med 161:1501-7. 2000
    ..The results support the theory that the RSV influences the mechanisms involved in the development of asthma and allergy in children...
  7. ncbi Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
    Malcolm G Semple
    Department of Child Health, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:382-6. 2005
    ..99 [95% confidence interval, 5.0-24.12]; P<.001, by Fisher exact test). Dual infection by hMPV and hRSV is associated with severe bronchiolitis...
  8. ncbi Nasal continuous positive airway pressure decreases respiratory muscles overload in young infants with severe acute viral bronchiolitis
    Gilles Cambonie
    Pediatric Intensive Care Unit, CHU Montpellier, 34000 Montpellier, France
    Intensive Care Med 34:1865-72. 2008
    ..To determine the efficacy of nasal continuous positive airway pressure (nCPAP) on respiratory distress symptoms and respiratory effort in young infants with acute respiratory syncytial virus bronchiolitis...
  9. ncbi Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis
    Cynthia A Bonville
    SUNY Upstate Medical University, Syracuse, NY 13210 2375, USA
    Virology 349:87-95. 2006
    ..and local production of proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis. With a reduced inoculum of this natural rodent pathogen, we observe virus clearance by day 9, while ..
  10. pmc Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis
    Avraham Beigelman
    Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St, Louis, MO USA
    Respir Res 11:90. 2010
    b>Viral bronchiolitis is the leading cause of hospitalization in young infants. It is associated with the development of childhood asthma and contributes to morbidity and mortality in the elderly...
  11. ncbi [Clinical and transcutaneous oxygen saturation characteristics in hospitalized infants with acute viral bronchiolitis]
    Fernanda M Rubin
    Pediatria, Universidade Federal do Rio Grande do Sul
    J Pediatr (Rio J) 79:435-42. 2003
    To describe the clinical characteristics of infants with acute viral bronchiolitis (AVB) and to assess the influence of oxygen desaturation time (DT) as a prognostic test to estimate the evolution of such patients.
  12. ncbi Randomized, double-blind, placebo-controlled trial of oral albuterol in infants with mild-to-moderate acute viral bronchiolitis
    Hema Patel
    Department of Pediatrics, McGill University, Quebec, Canada
    J Pediatr 142:509-14. 2003
    To determine whether oral albuterol is effective in reducing symptomatology of acute viral bronchiolitis in infants with mild-to-moderate illness.
  13. ncbi Previously healthy infants may have increased risk of aspiration during respiratory syncytial viral bronchiolitis
    V Khoshoo
    West Jefferson Medical Center, New Orleans, LA, USA
    Pediatrics 104:1389-90. 1999
    ..Respiratory illnesses may cause feeding difficulties in infants. We studied the safety of oral feeding during respiratory syncytial viral (RSV) bronchiolitis in previously healthy infants...
  14. pmc Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993-2000: a population-based retrospective study
    Hans Olav Fjaerli
    University of Oslo, Faculty Division Akershus University Hospital, 1474 Nordbyhagen, Norway
    BMC Pediatr 4:25. 2004
    ..The aims of the present study were to identify risk groups, outcome and incidences of hospitalisation for RSV bronchiolitis in Norwegian children under two years of age and to compare the results with other studies...
  15. pmc Nutritional status, breastfeeding, and evolution of Infants with acute viral bronchiolitis
    Cristina T L Dornelles
    Nutrition Departament, Hospital de Clínicas de Porto Alegre RS, Rua Ramiro Barcelos, 2350, 90035903 Porto Alegre RS, Brazil
    J Health Popul Nutr 25:336-43. 2007
    Acute viral bronchiolitis is a common respiratory infectious disease of infancy...
  16. ncbi Acute viral bronchiolitis in children- a very common condition with few therapeutic options
    Claire Wainwright
    Department of Paediatrics and Child Health, Queensland Children s Respiratory Centre, Royal Children s Hospital, University of Queensland, Herston Rd, Herston, Queensland, Australia 4029
    Paediatr Respir Rev 11:39-45; quiz 45. 2010
    Acute viral bronchiolitis remains a cause of substantial morbidity and health care costs in young infants. It is the most common lower respiratory tract condition and most common reason for admission to hospital in infants...
  17. ncbi Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants
    Brian A Kuzik
    Department of Paediatrics, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
    J Pediatr 151:266-70, 270.e1. 2007
    To investigate the use of nebulized 3% hypertonic saline (HS) for treating viral bronchiolitis in moderately ill hospitalized infants by a prospective, randomized, double-blinded, controlled, multicenter trial.
  18. ncbi Clarithromycin in the treatment of RSV bronchiolitis: a double-blind, randomised, placebo-controlled trial
    F Tahan
    Department of Paediatric Allergy, Erciyes University School of Medicine, Kayseri 38039, Turkey
    Eur Respir J 29:91-7. 2007
    ..Therefore, clarithromycin treatment may be helpful in reducing the short-term effects of respiratory syncytial virus bronchiolitis...
  19. ncbi A randomized, controlled trial of the effectiveness of nebulized therapy with epinephrine compared with albuterol and saline in infants hospitalized for acute viral bronchiolitis
    Hema Patel
    Department of Pediatrics, McGill University Health Centre, Montreal, Quebec, Canada
    J Pediatr 141:818-24. 2002
    In previously well infants hospitalized with acute viral bronchiolitis, the effectiveness of repeated nebulized therapy with epinephrine (EPI) was compared with treatment with albuterol (ALB) or saline placebo (PLAC).
  20. ncbi Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience
    Guy Tal
    Pediatric Pulmonary Unit, Wolfson Medical Center, Holon, Israel
    Isr Med Assoc J 8:169-73. 2006
    We recently published preliminary evidence on the effectiveness of hypertonic saline in infants with viral bronchiolitis.
  21. ncbi Neutrophil survival is prolonged in the airways of healthy infants and infants with RSV bronchiolitis
    A Jones
    University Institute of Child Health, Division of Clinical Sciences S, Western Bank, Sheffield, UK
    Eur Respir J 20:651-7. 2002
    ..The speculation is that the prolonged survival of neutrophils in the infant airway contributes to the characteristic accumulation of neutrophils in the airways of infants with respiratory infections...
  22. ncbi Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms
    E Michael Sarrell
    Pediatrics and Adolescent Ambulatory Community Clinic of General Health Services, The Edith Wolfson Medical Center, 62 Halochamim Street, Holon 58100, Israel
    Chest 122:2015-20. 2002
    To determine the utility of inhaled hypertonic saline solution to treat ambulatory infants with viral bronchiolitis.
  23. ncbi [Assessment of the French Consensus Conference for Acute Viral Bronchiolitis on outpatient management: progress between 2003 and 2008]
    M David
    Unité de médecine infantile, CHU Timone Enfants, 264, rue Saint Pierre, 13385 Marseille Cedex 5, France
    Arch Pediatr 17:125-31. 2010
    The 2000 French Consensus Conference for Acute Viral Bronchiolitis management underlined clinical practice recommendations.
  24. ncbi Inhaled furosemide in hospitalized infants with viral bronchiolitis: a randomized, double-blind, placebo-controlled pilot study
    Amir Bar
    Department of Pediatrics, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Pediatr Pulmonol 43:261-7. 2008
    ..To evaluate the short and long-term clinical effects and the treatment-feasibility of inhaled-furosemide (IF) as compared with placebo via hood in hospitalized infants with viral-bronchiolitis (VB)...
  25. ncbi Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis
    P S McNamara
    Dept of Child Health, University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool, UK
    Eur Respir J 23:106-12. 2004
    ..The decrease in tumour necrosis factor-alpha and interleukin-6 protein in preterm infants may reflect the prolonged clinical course seen in these infants...
  26. pmc Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 122:726-733.e3. 2008
    ..Immune response after viral infection usually involves T(H)1-mediated response; however, severe respiratory syncytial virus (RSV) infection appears to be associated with the development of asthma, a T(H)2-predominant phenotype...
  27. ncbi A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus
    Roberto P Garofalo
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
    J Med Virol 75:282-9. 2005
    ....
  28. pmc Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis
    P S McNamara
    Department of Child Health, University of Liverpool, Liverpool, UK
    Arch Dis Child 88:922-6. 2003
    ..Aim: To examine over time, the cellular response within the lungs of infants ventilated with respiratory syncytial virus (RSV) bronchiolitis and to compare this response in infants born at term with those born preterm...
  29. ncbi Respiratory syncytial virus bronchiolitis: supportive care and therapies designed to overcome airway obstruction
    Howard B Panitch
    Division of Pulmonary Medicine, Fifth Floor Wood Building, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 22:S83-7; discussion S87-8. 2003
    ....
  30. ncbi Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis
    Paul S McNamara
    Department of Child Health, University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool, UK
    Lancet 363:1031-7. 2004
    ..We aimed to investigate whether interleukin 9 was produced in the lungs of infants with severe RSV disease and if found, from which cells it originated...
  31. ncbi Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis
    Stefan Unger
    Department of Respiratory and Sleep Medicine, Royal Hospital for Sick Children Edinburgh, Sciennes Rd, Edinburgh, EH9 1LF, United Kingdom
    Pediatrics 121:470-5. 2008
    ..The goal was to establish the final supportive therapy determinants of hospital length of stay for bronchiolitis...
  32. ncbi Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13
    Nele Sigurs
    Department of Pediatrics, Borås Central Hospital, Boras, Sweden
    Am J Respir Crit Care Med 171:137-41. 2005
    ..RSV bronchiolitis in infancy severe enough to cause hospitalization is a risk factor for allergic asthma in early adolescence...
  33. ncbi Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona College of Medicine, PO Box 245030, 1501 N Campbell Avenue, Room 2349, Tucson, AZ 85764, USA
    Pediatr Infect Dis J 22:S76-82. 2003
    ..It is likely, however, that strategies for the prevention of RSV infection may play a role in the prevention of the subsequent development of persistent wheezing and asthma-like symptoms in childhood...
  34. ncbi Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches
    Peter J Openshaw
    Department of Respiratory Medicine St Mary s, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Hospital, London W2 1PG, UK
    Pediatr Infect Dis J 22:S58-64; discussion S64-5. 2003
    ..Further study is necessary to determine the relative roles of RSV infection and genetic predisposition in explaining the association between RSV infection and asthma/RAD...
  35. ncbi Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis
    Avigdor Mandelberg
    Pediatric Pulmonary Unit, The Edith Wolfson Medical Center, Holon, Israel
    Chest 123:481-7. 2003
    To determine the utility of inhaled hypertonic saline solution to treat infants hospitalized with viral bronchiolitis.
  36. ncbi T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis
    Maoxiang Li
    Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 1224, USA
    Toxicol Appl Pharmacol 217:76-85. 2006
    ..These effects might be attributable to reduced alveolar macrophage levels as well as modulated cytokine and mucosal Ig responses...
  37. ncbi South African guideline for the diagnosis, management and prevention of acute viral bronchiolitis in children
    Robin J Green
    University of Pretoria
    S Afr Med J 100:320, 322-5. 2010
    ..South African Thoracic Society, South African Society of Paediatric Infectious Diseases, United South African Neonatal Association...
  38. ncbi [Nosocomial viral infections in a pediatric service: example of rotaviral gastroenteritis and respiratory syncytial viral bronchiolitis]
    P Le Roux
    Département de pédiatrie groupe hospitalier, 55 bis, rue Gustave Flaubert, 76600 Le Havre, France
    Arch Pediatr 11:908-15. 2004
    ..Nosocomial infections are a preoccupation in a pediatric hospital mainly during the winter with bronchiolitis and gastroenteritis epidemics. We have examined the risk factors of nosocomial infections...
  39. ncbi Treatment of respiratory syncytial virus: antiviral therapies
    Hasan S Jafri
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Pediatr Infect Dis J 22:S89-92; discussion S92-3. 2003
    ..High risk patients, who meet the American Academy of Pediatrics criteria for RSV prophylaxis, may be candidates for passive prophylaxis...
  40. ncbi A meta-analysis of randomized controlled trials evaluating the efficacy of epinephrine for the treatment of acute viral bronchiolitis
    Lisa Hartling
    Alberta Research Center for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, USA
    Arch Pediatr Adolesc Med 157:957-64. 2003
    ..Controversy exists surrounding the use of bronchodilators for bronchiolitis. Epinephrine hydrochloride is being used with increasing frequency in this group; however, its efficacy has not been systematically reviewed...
  41. ncbi Outbreak of human metapneumovirus infection in norwegian children
    Henrik Døllner
    Department of Pediatrics, Trondheim University Hospital, Trondheim, Norway
    Pediatr Infect Dis J 23:436-40. 2004
    ..We have studied the occurrence of hMPV and report clinical findings of 50 hMPV-infected children who were hospitalized during an outbreak in Norway...
  42. ncbi Advances in the treatment and prevention of severe viral bronchiolitis
    Joseph B Domachowske
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Pediatr Ann 34:35-41. 2005
    b>Viral bronchiolitis continues to be a major public health problem...
  43. ncbi Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis
    Kostas N Priftis
    Allergology, Pulmonology Department, Penteli Children s Hospital, Athens, Greece
    Med Sci Monit 11:CR493-7. 2005
    ..The aim of this study was to test whether serum ECP and soluble CD23 levels, which are markers of eosinophil and IgE responses, respectively, are elevated in infants hospitalized for acute respiratory syncytial virus (RSV) bronchiolitis...
  44. ncbi Acute viral bronchiolitis and its sequelae in developing countries
    Gilberto Bueno Fischer
    Fundaçao Faculdade, Federal de Ciências Médicas de Porto Alegre, Rua Coronel Bordini 830 509, Bairro Moinhos de Vento, 90440 003 Porto Alegre, Brazil
    Paediatr Respir Rev 3:298-302. 2002
    Acute viral bronchiolitis (AVB) is a common disease found throughout the world. Various aspects of it are being studied: its epidemiology, diagnosis, prognosis and treatment...
  45. ncbi Phenotype of acute respiratory syncytial virus induced lower respiratory tract illness in infancy and subsequent morbidity
    H E Elphick
    University Division of Child Health, Sheffield Children s Hospital, Sheffield, UK
    Acta Paediatr 96:307-9. 2007
    ..Conclusion: The data argue that RSV infection during infancy does not induce allergic asthma and that host factors rather than the virus determine long-term outcomes...
  46. ncbi [Severe bronchiolitis. Epidemiology and clinical course of 284 patients]
    A López Guinea
    Servicio de Cuidados Intensivos Pediatricos, Hospital Infantil Universitario Nino Jesus, Madrid, Espana
    An Pediatr (Barc) 67:116-22. 2007
    ..The objective of this study was to analyze the characteristics and clinical course of patients admitted to the PICU for bronchiolitis...
  47. ncbi The histopathology of fatal untreated human respiratory syncytial virus infection
    Joyce E Johnson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Mod Pathol 20:108-19. 2007
    ..These findings inform our understanding of RSV pathogenesis and may facilitate the development of new approaches for prevention and treatment...
  48. ncbi Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
    Alma Martina Cepika
    Institute of Immunology, Zagreb University Hospital Center, Zagreb, Croatia
    Pediatr Allergy Immunol 19:148-56. 2008
    ..These data indicate existence of an event persisting after acute RSV infection that is able to modulate effector functions of cytotoxic T cells, and also link disease severity with CX(3)CR1 expression...
  49. ncbi Respiratory viruses in the pediatric intensive care unit: prevalence and clinical aspects
    Selir M Straliotto
    Laboratório Central de Saúde Pública, Seção de Virologia, Fundação Estadual de Produção e Pesquisa em Saúde, Av Ipiranga 5400, 90610 000 Porto Alegre, RS, Brazil
    Mem Inst Oswaldo Cruz 99:883-7. 2004
    ..8%) (p = 0.005). Injected antibiotics were used in 49% of the children with RSV and 60% of those with adenovirus. Adenovirus was not detected in any of the 33 children submitted to oxygen therapy...
  50. ncbi Respiratory syncytial virus infection and recurrent wheezing: a complex relationship
    H Cody Meissner
    J Pediatr 151:6-7. 2007
  51. pmc Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis
    Hans Olav Fjaerli
    University of Oslo, Faculty Division Akershus University Hospital, Department of Paediatrics, Akershus University Hospital, Norway
    BMC Infect Dis 6:175. 2006
    Respiratory syncytial virus (RSV) is a major cause of viral bronchiolitis in infants worldwide, and environmental, viral and host factors are all of importance for disease susceptibility and severity...
  52. ncbi A new direction in understanding the pathogenesis of respiratory syncytial virus bronchiolitis: how real infants suffer
    John P DeVincenzo
    J Infect Dis 195:1084-6. 2007
  53. ncbi CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population
    Yuzaburo Inoue
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Infect Dis 195:1618-24. 2007
    ....
  54. ncbi Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    Joseph P Bradley
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Pediatrics 115:e7-14. 2005
    ..Little is known about what determines the severity of RSV bronchiolitis, which may be helpful in the initial assessment of these children...
  55. ncbi Lack of usefulness of an abnormal white blood cell count for predicting a concurrent serious bacterial infection in infants and young children hospitalized with respiratory syncytial virus lower respiratory tract infection
    Kevin Purcell
    Healthcare Leaders 2B Pediatric Research 4U, Texas A and M University College of Medicine, Camino De Plata Court, Corpus Christi, TX 78418, USA
    Pediatr Infect Dis J 26:311-5. 2007
    ..The objective of this study was to determine the usefulness of an abnormal white blood cell (WBC) count for predicting a concurrent serious bacterial infection in patients admitted with RSV LRTI...
  56. pmc RSV testing in bronchiolitis: which nasal sampling method is best?
    P Macfarlane
    Department of Child Health, Rotherham General Hospital, UK
    Arch Dis Child 90:634-5. 2005
    ..The nasal swab procedure was significantly less painful but was negative in approximately one third of RSV positive cases...
  57. ncbi Severe bronchiolitis and respiratory syncytial virus among young children in Hawaii
    Krista L Yorita
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 26:1081-8. 2007
    ..Our objective was to describe the incidence and epidemiology of severe bronchiolitis, respiratory syncytial virus (RSV), and pneumonia among children in Hawaii...
  58. ncbi [Correlation between fever and the clinical severity of acute bronchiolitis]
    Angela Butnariu
    ClinicaPediatrie III, UMF Iuliu Hatieganu, Cluj Napoca
    Pneumologia 54:154-7. 2005
    ..The relationship between fever and the severity of acute infant bronchiolitis has been little studied, and the results of the few published studies are not concordant...
  59. ncbi Increased levels of BAL cysteinyl leukotrienesinacute [corrected] RSV bronchiolitis
    Chang Keun Kim
    Department of Paediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
    Acta Paediatr 95:479-85. 2006
    ..Among bronchiolitis subjects, high CysLT producers could be distinguished from low CysLT producers by the presence of eosinophilia in BAL fluids, suggesting a pathophysiological heterogeneity in RSV bronchiolitis...
  60. pmc Systemic eosinophil response induced by respiratory syncytial virus
    C A Lindemans
    Department of Pulmonary Diseases, University Medical Centre, Utrecht, The Netherlands
    Clin Exp Immunol 144:409-17. 2006
    ..Utilizing cellular markers, we observed that peripheral blood eosinophils from infants with RSV LRTD are in a more activated state compared to eosinophils of controls, which normalizes only partially during convalescence...
  61. ncbi Respiratory syncytial virus infections: old challenges and new opportunities
    Asuncion Mejias
    Division of Pediatric Infectious Diseases, The University of Texas Southwestern Medical Center and Children s Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Pediatr Infect Dis J 24:S189-96, discussion S196-7. 2005
    ..RSV also causes repeated infections including severe lower respiratory tract disease, which may occur at any age, especially among the elderly or those with compromised cardiac, pulmonary, or immune systems...
  62. pmc Timing of monoclonal antibody for seasonal RSV prophylaxis in the United Kingdom
    N L Goddard
    Health Protection Agency Centre for Infections, London, UK
    Epidemiol Infect 135:159-62. 2007
    ..Promptly commencing prophylaxis during the second week of each October (week 42) would precede the onset of the RSV season in the United Kingdom, and provide coverage until its decline in mid-March...
  63. ncbi Virus-induced airway dysfunction: pathogenesis and biomechanisms
    Azzeddine Dakhama
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    Pediatr Infect Dis J 24:S159-69, discussion S166-7. 2005
    ..However, it is not clear whether this association is "causal" or "circumstantial."..
  64. ncbi Human metapneumovirus and respiratory syncytial virus detection in young children with acute bronchiolitis
    Jamaree Teeratakulpisarn
    Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand
    Asian Pac J Allergy Immunol 25:139-45. 2007
    ..The clinical manifestations among the 6 hMPV, RSV and non-RSV-infected children were similar. RSV was the leading cause of acute bronchiolitis in young children and hMPV had a low prevalence in northeastern Thailand...
  65. ncbi Treatment of bronchiolitis in infants
    Howard B Panitch
    Department of Pediatrics, University of Pennsylvania School of Medicine, and the Division of Pulmonary Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Case Rev 3:3-19. 2003
  66. ncbi Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free
    M G Semple
    Division of Child Health, School of Reproductive and Developmental Medicine, School of Infection and Host Defence, University of Liverpool, United Kingdom
    J Clin Virol 40:241-4. 2007
    ..Nasopharyngeal secretions aspirated from infants with bronchiolitis (NPA) are a valuable resource for the study of virus dynamics and local inflammatory responses, however samples are small and difficult to manipulate...
  67. pmc Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway
    Hans Olav Fjaerli
    Faculty Division, Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Norway
    BMC Pediatr 5:31. 2005
    Acute viral bronchiolitis is one of the most common causes of hospitalisation during infancy in our region with respiratory syncytial virus (RSV) historically being the major causative agent...
  68. ncbi Encephalopathy associated with respiratory syncytial virus bronchiolitis
    Y T Ng
    Department of Neurology, University of Texas-Houston Medical School, 77030, USA
    J Child Neurol 16:105-8. 2001
    ..Furthermore, respiratory syncytial virus has been shown to release several mediators that could directly or indirectly be neurotoxic and induce an encephalopathy associated with the respiratory illness...
  69. pmc Viral respiratory infection and the link to asthma
    James E Gern
    Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Pediatr Infect Dis J 27:S97-103. 2008
    ....
  70. ncbi Respiratory syncytial virus infection and neurologic abnormalities: retrospective cohort study
    Nathaniel Kho
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Child Neurol 19:859-64. 2004
    ....
  71. ncbi The complex relationship between respiratory syncytial virus and allergy in lung disease
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Viral Immunol 16:25-34. 2003
    ..We also review the published murine models that combine RSV infection and allergic sensitization that attempt to explain the complex relationship between these two factors in regard to lung immunopathology and physiologic dysfunction...
  72. pmc Respiratory syncytial virus infection suppresses IFN-gamma production of gammadelta T cells
    M Aoyagi
    Department of Paediatrics and Clinical Research, National Shimoshizu Hospital, Yotsukaido, Chiba, Japan
    Clin Exp Immunol 131:312-7. 2003
    ..25-10.98%; P < 0.005). Cytokine production by gammadelta T cells may therefore be important in the pathogenesis of acute RSV disease, and play a part in the development of recurrent childhood wheezing after bronchilolitis...
  73. ncbi Interleukin-6, interleukin-8, interleukin-11, and interferon-gamma levels in nasopharyngeal aspirates from wheezing children with respiratory syncytial virus or influenza A virus infection
    Jae Won Oh
    Department of Pediatrics, Hanyang University, College of Medicine, Seoul, Korea
    Pediatr Allergy Immunol 13:350-6. 2002
    ..In conclusion, asthma enhanced IL-11 production in RSV infection rather than IFAV infection in early childhood. There was a trend towards greater IL-6 production in RSV infection compared with IFAV infection...
  74. ncbi A cohort of children hospitalised with acute RSV bronchiolitis: impact on later respiratory disease
    Nele Sigurs
    Paediatric Department, Borås Central Hospital, Boras, Sweden
    Paediatr Respir Rev 3:177-83. 2002
    ..Prospective studies are needed with some kind of randomised intervention against RSV before the mechanisms behind the post-bronchiolitic symptoms and the possibly increased risk for IgE mediated allergy can be settled...
  75. ncbi Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy
    P Pala
    Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Eur Respir J 20:376-82. 2002
    ..Respiratory syncytial virus bronchiolitis in infancy may increase the risk of allergic sensitisation by providing a local interleukin-4-rich environment, in which airborne allergens are first encountered...
  76. ncbi Effect of interventions during acute respiratory syncytial virus bronchiolitis on subsequent long term respiratory morbidity
    Vikram Khoshoo
    Department of Pediatrics, West Jefferson Medical Center, New Orleans, LA, USA
    Pediatr Infect Dis J 21:468-72. 2002
  77. ncbi Beta-agonist aerosol distribution in respiratory syncytial virus bronchiolitis in infants
    Israel Amirav
    Department of Pediatric Pulmonology, Rebecca Sieff Governmental Hospital, Safed, Israel
    J Nucl Med 43:487-91. 2002
    ..This study evaluated the lower respiratory tract distribution characteristics of nebulized bronchodilators in infants with acute bronchiolitis...
  78. ncbi Bronchiolitis: update 2001
    Cory Schlesinger
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Curr Opin Pulm Med 8:112-6. 2002
    ....
  79. ncbi Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    Pediatr Infect Dis J 27:S92-6. 2008
    ..Severe infantile RSV and influenza virus LRTI is characterized by inadequate (rather than excessive) adaptive immune responses, robust viral replication and apoptotic crisis...
  80. ncbi Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis
    D Dimova-Yaneva
    Department of Child Health, University of Aberdeen, Aberdeen, UK
    Clin Exp Allergy 34:555-8. 2004
    ..ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes...
  81. ncbi Improved outcomes with home-based administration of palivizumab: results from the 2000-2004 Palivizumab Outcomes Registry
    Michael Frogel
    Schneider Children s Hospital, New Hyde Park, NY 11042, USA
    Pediatr Infect Dis J 27:870-3. 2008
    ....
  82. ncbi Prospective evaluation of a dot-blot enzyme immunoassay (Directigen RSV) for the antigenic detection of respiratory syncytial virus from nasopharyngeal aspirates of paediatric patients
    J Reina
    Virology Unit, Clinical Microbiology Service, University Hospital Son Dureta Universitat Illes Balears, Palma de Mallorca, Spain
    Clin Microbiol Infect 10:967-71. 2004
    ..8% and a specificity of 100%. Overall, the ColorPAC assay was an acceptable, simple and rapid method for the antigenic detection of RSV in paediatric respiratory samples...
  83. ncbi Elevated levels of soluble adhesion molecules in sera of patients with acute bronchiolitis
    Chou Cheng Lai
    Department of Pediatrics, Taipei Veterans General Hospital, and National Yang Ming University, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:153-6. 2004
    ..However, the serum concentrations of the soluble adhesion molecules could not reliably reflect the clinical severity of the disease...
  84. ncbi Soluble CD14 as a predictor of subsequent development of recurrent wheezing in hospitalized young children with respiratory syncytial virus-induced bronchiolitis
    Ruth Soferman
    Pediatric Pulmonology Clinic, Dana Children s Hospital, Tel Aviv, Israel
    Ann Allergy Asthma Immunol 92:545-8. 2004
    ..The CD14 receptor responds to the microbial burden in the environment and modulates the development of the allergic phenotype...
  85. ncbi Do systemic corticosteroids improve acute outcomes in infants with RSV bronchiolitis?
    Jeanie Smith
    J Okla State Med Assoc 101:14. 2008
  86. ncbi [Concentrations of interleukin-2 in the nasopharyngeal secretion of children with acute respiratory syncytial virus bronchiolitis]
    Katia M Giugno
    Dep Pediatria, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre FFFCMPA, Porto Alegre, RS
    J Pediatr (Rio J) 80:315-20. 2004
    ....
  87. pmc Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
    Kimberly D Dyer
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virol J 4:48. 2007
    ..is a natural respiratory pathogen of rodent species and an important new model for the study of severe viral bronchiolitis and pneumonia...
  88. ncbi The potential impact of prophylaxis against bronchiolitis due to the respiratory syncytial virus in children with congenital cardiac malformations
    Oliver J Rackham
    Paediatric Intensive Care Unit, Alder Hey Hospital, Royal Liverpool Children s Hospital, Liverpool, United Kingdom
    Cardiol Young 15:251-5. 2005
    ....
  89. ncbi Comparison of the effects that two different respiratory physical therapy techniques have on cardiorespiratory parameters in infants with acute viral bronchiolitis
    Melissa Karina Pupin
    Departamento de Pediatria, Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Bras Pneumol 35:860-7. 2009
    ..compare the expiratory flow increase technique (EFIT) and vibration accompanied by postural drainage (PD) in terms of their effects on the heart rate (HR), respiratory rate (RR) and SpO(2) of infants with acute viral bronchiolitis (AVB).
  90. ncbi Validity of markers of dilution in small volume lung lavage
    P A Dargaville
    Department of Neonatology, University Department of Paediatrics, and Department of Biochemistry, Royal Children s Hospital, Melbourne, Australia
    Am J Respir Crit Care Med 160:778-84. 1999
    ..the diseased and normal lung, but in the NB-BAL samples, significantly higher SC concentration was noted in viral bronchiolitis and pneumonia than in noninfective lung diseases...
  91. ncbi Antileukotrienes in the treatment of asthma and allergic rhinitis
    Jose Dirceu Ribeiro
    Setor de Pneumologia Pediátria, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    J Pediatr (Rio J) 82:S213-21. 2006
    ..To compare leukotriene antagonists (LTA) to other groups of drugs used in asthma and allergic rhinitis treatment...
  92. ncbi Chronic postbronchiolitis airway instability induced with anti-IFN-gamma antibody in F344 rats
    Ronald L Sorkness
    Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Pediatr Res 52:382-6. 2002
    ..We conclude that there is an interactive effect of a weak IFN-gamma response and viral bronchiolitis at an early age that may result in persistent postbronchiolitis airway dysfunction...
  93. ncbi [Bronchiolitis treated with mechanical ventilation: prognosis factors and outcome in a series of 135 children]
    L Chevret
    Service de Réanimation Pédiatrique, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Arch Pediatr 12:385-90. 2005
    b>Viral bronchiolitis is usually associated with favorable outcome as regard to mortality. Only few studies reported severe bronchiolitis requiring mechanical ventilation, and respiratory outcome is not well described.
  94. ncbi Bronchiolitis: recent evidence on diagnosis and management
    Joseph J Zorc
    MSCE, Children s Hospital of Philadelphia, Division of Emergency Medicine, Main AS01, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Pediatrics 125:342-9. 2010
    b>Viral bronchiolitis is a leading cause of acute illness and hospitalization of young children...
  95. ncbi Contribution of airway closure to chronic postbronchiolitis airway dysfunction in rats
    Ronald L Sorkness
    Department of Medicine, Morris Institute for Respiratory Research, School of Pharmacy, University of Wisconsin, Madison 53792, USA
    J Appl Physiol (1985) 96:904-10. 2004
    Genetically susceptible Brown Norway rats develop a chronic asthmalike syndrome after recovering from viral bronchiolitis at an early age...
  96. ncbi [Diagnostic considerations in unilateral hyperlucency of the lung (Swyer-James-MacLeod Syndrome)]
    M Tortajada
    , , Hospital Universitario Dr Peset, Universidad de Valencia, Avda Gaspart Aguilar 90, 46017 Valencia, Spain
    Allergol Immunopathol (Madr) 32:265-70. 2004
    ..This syndrome seems to be an acquired disease that develops after viral bronchiolitis and/or viral pneumonia in early childhood...
  97. ncbi Right pulmonary agenesis associated with remaining bronchus stenosis, an equivalent of postpneumonectomy syndrome. Treatment by insertion of tissue expander in the thoracic cavity
    E Dobremez
    Department of Pediatric Surgery, Hôpital Pellegrin Enfants, Bordeaux, 33076, France
    Pediatr Surg Int 21:121-2. 2005
    We report a case of right pulmonary agenesis with worsening of mediastinal shift during a viral bronchiolitis at the age of 5 months...
  98. ncbi Association between hypoparathyroidism and defective T cell immunity in 22q11.2 deletion syndrome
    A Herwadkar
    Department of Immunology, Salford Royal Hospital NHS Trust, Manchester, UK
    J Clin Pathol 63:151-5. 2010
    ..The aim of this study was to investigate which clinical and laboratory parameters best predict the likelihood of serious or recurrent infections in patients with this syndrome...
  99. ncbi [Respiratory emergencies in infants]
    B Llanas
    Service des urgences pédiatriques, Hôpital des enfants Pellegrin 33 076 Bordeaux
    Rev Prat 51:1884-91. 2001
    ..Moreover, during winter acute viral bronchiolitis is the most common disease of the respiratory tract during the first year of life, and occurs in annual ..
  100. ncbi Current therapies in bronchiolitis
    Frank D Petruzella
    Division of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Pediatr Emerg Care 26:302-7; quiz 308-11. 2010
    b>Viral bronchiolitis is the most common cause of hospitalization among infants...
  101. pmc Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease
    Michael J Holtzman
    Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Am Thorac Soc 2:132-40. 2005
    ..Using a mouse model of viral bronchiolitis, we found that antiviral defense depends at least in part on a network of mucosal epithelial cells and ..

Research Grants16

  1. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  2. PGE2 Regulation of Allergic Inflammation in the Lung
    RAY PEEBLES; Fiscal Year: 2007
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. [unreadable] [unreadable]..
  3. Role of Calcium-Activated Chloride Channels in Airway Disease Phenotypes
    ANAND CHAMPAK PATEL; Fiscal Year: 2011
    ..Studies will be performed in vivo using our mouse models of viral bronchiolitis and allergen challenge and in vitro using primary-culture mouse airway epithelial cells grown at air-liquid ..
  4. VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH
    William Castleman; Fiscal Year: 1992
    ..and tissue mechanisms responsible for bronchiolar hypoplasia and alveolar dysplasia that result from viral bronchiolitis and pneumonia during early life...
  5. 2-5A ANTISENSE INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS
    Hagen Cramer; Fiscal Year: 1999
    ..It is the most common cause of viral bronchiolitis and pneumonia in children, and outbreaks in the United States frequently reach epidemic proportions during ..
  6. 2-5A ANTISENSE INHIBITION OF RESPIRATORY SYNCTIAL VIRUS
    Hagen Cramer; Fiscal Year: 2001
    ..It is the most common cause of viral bronchiolitis and pneumonia in children, and outbreaks frequently reach epidemic proportions during the winter months, ..
  7. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2008
    ..abstract_text> ..
  8. VIRUS INDUCED GENE EXPRESSION IN AIRWAY EPITHELIAL CELLS
    MICHAEL HOLTZMAN; Fiscal Year: 2002
    ....
  9. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  10. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  11. Improving Follow-up After an Emergency Visit for Asthma
    Joseph Zorc; Fiscal Year: 2007
    ..The expected goal of the project will be to develop an intervention that can subsequently be tested in a newly developed, federally-funded research network of pediatric EDs. ..
  12. Prostacyclin (PG12) Regulation of Respiratory Syncytial Virus (RS)induced Illness
    RAY PEEBLES; Fiscal Year: 2007
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  13. Immunomodulatory Mechanisms of Sublingual Immunotherapy
    Louis Rosenthal; Fiscal Year: 2006
    ..To investigate this controversial therapy, these studies will use a novel rat model to compare the efficacy of high vs. low doses of allergen drops and to elucidate mechanisms of sublingual immunotherapy. ..
  14. VIRUS-INDUCIBLE REMODELING OF AIRWAY EPITHELIUM
    MICHAEL HOLTZMAN; Fiscal Year: 2002
    ..abstract_text> ..
  15. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  16. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..