murine acquired immunodeficiency syndrome

Summary

Summary: Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.

Top Publications

  1. pmc Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade
    Wen Li
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Virol 85:13342-53. 2011
  2. pmc The role of CD4 T cells in the pathogenesis of murine AIDS
    Wen Li
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Virol 80:5777-89. 2006
  3. ncbi Quantitative analysis of LP-BM5 murine leukemia retrovirus RNA using real-time RT-PCR
    W James Cook
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Borwell Building, One Medical Center Drive, Lebanon, NH 03756, USA
    J Virol Methods 108:49-58. 2003
  4. pmc The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules
    Kathy A Green
    Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
    J Virol 76:13106-10. 2002
  5. pmc Characterization of the CD154-positive and CD40-positive cellular subsets required for pathogenesis in retrovirus-induced murine immunodeficiency
    K A Green
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    J Virol 75:3581-9. 2001
  6. ncbi CD19 signaling pathways play a major role for murine AIDS induction and progression
    Sonja M Knoetig
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    J Immunol 169:5607-14. 2002
  7. ncbi Inhibition of murine AIDS by a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphonomethoxypropyl)adenine
    Luigia Rossi
    Institute of Biochemistry G Fornaini and Institute of Hygiene, University of Urbino, Via Saffi, 2 61029 Urbino PU, Italy
    J Antimicrob Chemother 50:639-47. 2002
  8. pmc Development of a real-time PCR assay using SYBR Green I for provirus load quantification in a murine model of AIDS
    Anna Casabianca
    Institute di Biological Chemistry Giorgio Fornaini, University of Urbino, Italy
    J Clin Microbiol 42:4361-4. 2004
  9. pmc Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice
    S K Chattopadhyay
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:4232-41. 1991
  10. ncbi Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea
    Christopher N Mayhew
    Department of Clinical Sciences, University of Kentucky Medical Center, CHS Building, 900 South Limestone Street, Lexington, KY 40536, USA
    Antiviral Res 56:167-81. 2002

Research Grants

Scientific Experts

  • Ling Cao
  • Virginia D McLane
  • Wen Li
  • R D Dix
  • M Magnani
  • Y Sei
  • R R Watson
  • A W Hugin
  • Kenji Suzuki
  • A Fraternale
  • C F Qi
  • W R Green
  • Masahiko Ito
  • Arti Gaur
  • H C Morse
  • Manfred W Beilharz
  • M C Lopez
  • Laurence de Leval
  • C Oussoren
  • Mohan Sopori
  • Christine L Clouser
  • Yinhong Chen
  • Christopher N Mayhew
  • Anna Casabianca
  • Kathy A Green
  • Vincent S Gallicchio
  • Ramón Tomás Sepúlveda
  • W James Cook
  • Sheila P Kelley
  • Souad Rahmouni
  • M Makino
  • Jin Zhang
  • Megan A O'Connor
  • R Tomás Sepúlveda
  • Emily L Blalock
  • Manohar B Mutnal
  • T N Fredrickson
  • Philip H Jones
  • Mary Mullett
  • Colleen M Holtz
  • Steven E Patterson
  • Jacquie E Briggs
  • Louis M Mansky
  • Randi Mosenden
  • Jin Nyoung Ho
  • Kiho Cho
  • Howard L Elford
  • Chiara Orlandi
  • Paul F McDonagh
  • Grace Davis-Gorman
  • S Serafini
  • O Kanagawa
  • Deug Nam Kwon
  • Suprawee Tepsuporn
  • Kjetil Tasken
  • J W Hartley
  • Michel Moutschen
  • Kanako Takahashi
  • Andrea Paun
  • Mohammed S Inayat
  • L Ryan Sumpter
  • E Lubashevsky
  • Kam Fai Tse
  • Julie Beischel
  • Jonathan D Phillips
  • A Casabianca
  • Douglas F Larson
  • John Weekes
  • Shiro Watanabe
  • Qianli Yu
  • Alysia A Chaves
  • Suzanne Y Stevens
  • Lee J Grota
  • Y Yoshikai
  • Jan A Moynihan
  • David L Felten
  • Michael H Yen
  • Masayuki Umemura
  • N A Giese
  • Buyean Lee
  • Sonja M Knoetig
  • Luigia Rossi
  • Yingying Liu
  • Shuxian Hu
  • James R Lokensgard
  • Scott J Schachtele
  • Hsin Chien
  • Harshini V Mehta
  • Chioma M Okeoma
  • K A Green

Detail Information

Publications124 found, 100 shown here

  1. pmc Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade
    Wen Li
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Virol 85:13342-53. 2011
    ....
  2. pmc The role of CD4 T cells in the pathogenesis of murine AIDS
    Wen Li
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Virol 80:5777-89. 2006
    ..Similarly, there was no evidence that natural T-regulatory cells played a role in LP-BM5-induced pathogenesis in the context of the intact CD4 T-cell population...
  3. ncbi Quantitative analysis of LP-BM5 murine leukemia retrovirus RNA using real-time RT-PCR
    W James Cook
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Borwell Building, One Medical Center Drive, Lebanon, NH 03756, USA
    J Virol Methods 108:49-58. 2003
    ..The assays described below can be used to characterize better the contributions of different functional viral components of the LP-BM5 mixture to the development of MAIDS...
  4. pmc The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules
    Kathy A Green
    Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
    J Virol 76:13106-10. 2002
    ..Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86(-/-) B6 mice develop MAIDS after LP-BM5 infection...
  5. pmc Characterization of the CD154-positive and CD40-positive cellular subsets required for pathogenesis in retrovirus-induced murine immunodeficiency
    K A Green
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    J Virol 75:3581-9. 2001
    ....
  6. ncbi CD19 signaling pathways play a major role for murine AIDS induction and progression
    Sonja M Knoetig
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    J Immunol 169:5607-14. 2002
    ..Finally, CD22 deficiency was found to accelerate MAIDS development. These results provide novel insights into the B cell signaling pathways required for normal induction and progression of MAIDS...
  7. ncbi Inhibition of murine AIDS by a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphonomethoxypropyl)adenine
    Luigia Rossi
    Institute of Biochemistry G Fornaini and Institute of Hygiene, University of Urbino, Via Saffi, 2 61029 Urbino PU, Italy
    J Antimicrob Chemother 50:639-47. 2002
    ..Thus, no synergy between PMPA and AZT was observed in murine AIDS and administration of AZT does not improve the antiviral results obtained by PMPA administration...
  8. pmc Development of a real-time PCR assay using SYBR Green I for provirus load quantification in a murine model of AIDS
    Anna Casabianca
    Institute di Biological Chemistry Giorgio Fornaini, University of Urbino, Italy
    J Clin Microbiol 42:4361-4. 2004
    ..e., LP-BM5 infection) was developed and validated. In this method, data are normalized against the 18S rRNA gene. The method has a dynamic range of 8 logs and a sensitivity of one copy...
  9. pmc Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice
    S K Chattopadhyay
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:4232-41. 1991
    ..Finally, mRNA crosshybridizing with a probe for BM5d was present in spleen but not kidney cells of uninfected B6 mice...
  10. ncbi Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea
    Christopher N Mayhew
    Department of Clinical Sciences, University of Kentucky Medical Center, CHS Building, 900 South Limestone Street, Lexington, KY 40536, USA
    Antiviral Res 56:167-81. 2002
    ..These results suggest that due to their reduced hematopoietic toxicity and ability to inhibit disease progression in murine AIDS, TX and DX may offer effective alternatives to HU therapy in HIV-1 infection...
  11. ncbi Tsl and LP-BM5: a comparison of two murine retrovirus models for HIV
    S Clark
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614-5804, USA
    Viral Immunol 14:95-109. 2001
    ..Based on an extensive evaluation of the literature on LP-BM5 and ts1, it is concluded that the ts1 virus may serve as a better animal model to human retrovirus infection...
  12. ncbi Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative disease
    Christopher N Mayhew
    Department of Clinical Sciences, University of Kentucky Medical Center, Lexington, KY, USA
    Antiviral Res 65:13-22. 2005
    ..Moreover, the novel RR inhibitors TX and DX appear to be more effective and less myelosuppressive than HU when administered with ddI in this model...
  13. ncbi Timed ablation of regulatory CD4+ T cells can prevent murine AIDS progression
    Manfred W Beilharz
    Discipline of Microbiology, School of Biological and Chemical Sciences, University of Western Australia, Nedlands, Australia
    J Immunol 172:4917-25. 2004
    ..These data define a new therapy for murine retroviral infection, which has potential for use in other diseases where T regulator cell-mediated immunosuppression plays a role in the disease process...
  14. pmc Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5819-24. 1994
    ..These results indicate that induction of MAIDS by BM5def is antigen driven and is dependent on expression of major histocompatibility complex class II molecules on antigen-presenting cells and the presence of CD4+ T cells...
  15. ncbi Resistance to murine acquired immunodeficiency syndrome (MAIDS)
    R A Morawetz
    Science 265:264-6; author reply 267. 1994
  16. ncbi Macrophage protection by addition of glutathione (GSH)-loaded erythrocytes to AZT and DDI in a murine AIDS model
    A Fraternale
    Institute of Biological Chemistry Giorgio Fornaini, University of Urbino, Via Saffi, 2 61029 PU, Italy
    Antiviral Res 56:263-72. 2002
    ..This study may help developing strategies aimed at blocking HIV-1 replication in its reservoirs in the body...
  17. ncbi Effects of LP-BM5 murine leukemia virus infection on errors and response time in a two-choice serial reaction time task in C57BL/6 mice
    Buyean Lee
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Brain Res 948:1-7. 2002
    ..Inoculation with the LP-BM5 murine leukemia virus (MuLV) causes profound immunosuppression (murine acquired immunodeficiency syndrome, or MAIDS) in C57BL/6 mice...
  18. ncbi Activation-dependent apoptosis in CD4+ T cells during murine AIDS
    D A Cohen
    Department of Microbiology and Immunology, University of Kentucky, College of Medicine, Lexington 40536 0084
    Cell Immunol 151:392-403. 1993
    ....
  19. pmc The murine AIDS defective provirus acts as an insertional mutagen in its infected target B cells
    M Huang
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    J Virol 69:4069-78. 1995
    ....
  20. ncbi Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus
    T M Nguyen
    CNRS, URA 583, Universite Paris V, Hopital Saint Vincent de Paul, France
    Endocrinology 138:5505-10. 1997
    ..These findings suggest close local interactions between 1,25-(OH)2D3 and immune system activation during retroviral infection...
  21. ncbi Basic fibroblast growth factor (bFGF) and its receptor expression (bek and flg) In bone marrow stroma of murine AIDS
    Kam Fai Tse
    Hematology Oncology Division, Laboratory of Experimental Immunohematopoiesis and Developmental Therapeutics, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536 0084, USA
    Virus Res 101:175-84. 2004
    ..These results suggest a role for bFGF deficiency in the pathogenesis of MAIDS-related marrow failure...
  22. ncbi Sympathetic nerve destruction in spleen in murine AIDS
    Sheila P Kelley
    Center for Psychoneuroimmunology Research, University of Rochester Medical Center, 300 Crittenden Boulevard, 14642, Rochester, NY, USA
    Brain Behav Immun 17:94-109. 2003
    ..the LP-BM5 mixture of murine retroviruses induces the fatal immunodeficiency disease known as murine acquired immunodeficiency syndrome (murine AIDS or MAIDS)...
  23. ncbi Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection
    M Umemura
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan
    J Leukoc Biol 69:138-48. 2001
    ..Thus, it appeared that impaired production of IL-15, besides other inflammatory cytokines, in MAIDS mice may be involved in the poor responses of the NK and Th1 cells, resulting in an increased susceptibility to BCG...
  24. ncbi Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway
    R D Dix
    Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Arch Virol 149:2235-44. 2004
    ..Protection was not achieved, however, in recipient mice with retrovirus-induced immunodeficiency (MAIDS), even when splenic cells originated from MCMV-immunized normal mice...
  25. ncbi Interleukin-2 immunotherapy and AIDS-related cytomegalovirus retinitis
    Richard D Dix
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Curr HIV Res 2:333-42. 2004
    ..We envision systemic cytokine immunotherapy as an altemative or adjunct to traditional antiviral chemotherapy for optimal management of AIDS-related HCMV retinitis...
  26. ncbi T-cell receptor-derived peptides in immunoregulation and therapy of retrovirally induced immunosuppression
    J J Marchalonis
    Microbiology and Immunology, College of Medicine, University of Arizona, Tucson 85724, USA
    Crit Rev Immunol 21:57-74. 2001
    ..Our studies are interpreted in the context of other recent investigations of immunomodulatory peptides...
  27. ncbi Delayed progression of murine AIDS in C57BL/6 mice pre-immunized with a highly antigenic 10-mer peptide encoded by the murine AIDS defective virus gag p12 gene
    T Mizuochi
    Department of Bacterial and Blood Products, National Institute of Infectious Diseases, Tokyo, Japan
    Vaccine 16:2026-30. 1998
    ..This segregation between CTL activity and in vivo protection efficacy might be worth considering when we exploit vaccines for augmenting cellular immunity mediated by CD8+ T cells...
  28. ncbi Extracellular glutamate levels are chronically elevated in the brains of LP-BM5-infected mice: a mechanism of retrovirus-induced encephalopathy
    M G Espey
    Laboratory of Neuroscience, National Institute of Digestive Disorders and Kidney, National Institutes of Health, Bethesda, Maryland 20892 0008, USA
    J Neurochem 71:2079-87. 1998
    ....
  29. pmc Murine cytomegalovirus downregulates interleukin-17 in mice with retrovirus-induced immunosuppression that are susceptible to experimental cytomegalovirus retinitis
    Emily L Blalock
    Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA 30303, United States
    Cytokine 61:862-75. 2013
    ....
  30. pmc Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model
    Megan A O'Connor
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA
    J Virol 88:2349-53. 2014
    ..Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences. ..
  31. ncbi Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction
    O Kanagawa
    Department of Pathology, Washington School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 25:2421-7. 1995
    b>Murine acquired immunodeficiency syndrome (MAIDS) is caused by a defective murine leukemia virus. The disease is characterized by abnormal lymphoproliferation, impaired T and B cell function and aberrant regulation of cytokines...
  32. ncbi New drug combinations for the treatment of murine AIDS and macrophage protection
    A Fraternale
    Istituto di Chimica Biologia G. Fornaini, University of Urbino, Via Saffi, 61029-Urbino, Italy
    Eur J Clin Invest 31:248-52. 2001
    ....
  33. ncbi Changes in mesenteric lymph node T cell phenotype and B and T cell homing properties after murine AIDS infection
    M C Lopez
    Department of Health Promotion Sciences, College of Public Health, University of Arizona, Tucson, USA
    Lymphology 35:76-86. 2002
    ..These data indicate that murine AIDS infection altered the mucosal immune system while modifying MLN T cell phenotype and MLN T and B cells migratory properties...
  34. ncbi Quantitation of defective and ecotropic viruses during LP-BM5 infection by real time PCR and RT-PCR
    Andrea Paun
    Discipline of Microbiology, School of Biological and Chemical Sciences, The University of Western Australia, Nedlands, WA 6009, Australia
    J Virol Methods 124:57-63. 2005
    ..The assays described can be used as both a diagnostic tool and to investigate the direct effect of treatments on the BM5d and BM5e viruses and MAIDS development...
  35. pmc Citrobacter-induced colitis in mice with murine acquired immunodeficiency syndrome
    T N Fredrickson
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Vet Pathol 47:312-7. 2010
    ..conventional nonspecific pathogen-free colony, 41 of these having concomitant retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS)...
  36. ncbi Neutrophil activation by murine retroviral infection during chronic ethanol consumption
    Yinhong Chen
    Divison of Health Prevention Science, College of Public Health and Cardiovascular and Thoracic Surgery and The Sarver Heart Center, School of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Alcohol Alcohol 38:109-14. 2003
    ..The aim of this study was to determine if neutrophils are activated in murine AIDS and/or chronic ethanol consumption and if neutrophil CD11b expression and ROS production vary when progressive retrovirus infection occurs...
  37. ncbi Resistance to murine AIDS in offspring of mice infected with LP-BM5. Role of CD8 T cells
    J H Pavlovitch
    CNRS URA 583, Necker Hospital, Paris, France
    J Immunol 156:4757-63. 1996
    ..The offspring of MAIDS mice could clear the virus after challenge. This clearance was mediated by CD8 T cells, as continuous CD8 T cell depletion initiated at the time of viral challenge abrogated the resistance of these mice to MAIDS...
  38. ncbi Polymorphism at the tumor necrosis factor-alpha locus and susceptibility to toxoplasmic encephalitis, ultraviolet B-induced immune impairment, and mouse AIDS
    V Vincek
    J Acquir Immune Defic Syndr 7:734-5. 1994
  39. ncbi Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice
    Jin Nyoung Ho
    Department of Medical Nutrition, Graduate School of East West Science, Kyung Hee University, Gyeonggi, Korea
    Biosci Biotechnol Biochem 75:1234-9. 2011
    ....
  40. ncbi Analysis of the helper virus in murine retrovirus-induced immunodeficiency syndrome: evidence for immunoselection of the dominant and subdominant CTL epitopes of the BM5 ecotropic virus
    Arti Gaur
    Department of Microbiology and Immunology, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Viral Immunol 16:203-12. 2003
    ..This CTL evasion mechanism may contribute substantially to the underlying prototypic susceptibility of B6 mice to LP-BM5-induced MAIDS...
  41. pmc Activity of a novel combined antiretroviral therapy of gemcitabine and decitabine in a mouse model for HIV-1
    Christine L Clouser
    Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA
    Antimicrob Agents Chemother 56:1942-8. 2012
    ..These findings indicate that the combination of decitabine and gemcitabine shows potent antiretroviral activity at nontoxic doses and should be further investigated for clinical relevance...
  42. ncbi Identification of putative endogenous retroviruses actively transcribed in the brain
    Deug Nam Kwon
    Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California and Department of Surgery, University of California, Davis, 2425 Stockton Blvd, Sacramento, CA 95817, USA
    Virus Genes 36:439-47. 2008
    ..g., gag and env polypeptides) as well as interactions with flanking host genes...
  43. pmc STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:7093-5. 1999
    ..In addition, serum IgE levels were indistinguishable in mice of either genotype. We conclude that B cells from mice with MAIDS activate unique IL-4- and STAT6-independent signaling pathways for B-cell activation and differentiation...
  44. pmc Morphine increases hippocampal viral load and suppresses frontal lobe CCL5 expression in the LP-BM5 AIDS model
    Virginia D McLane
    Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04473, USA Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA Center for Excellence in the Neurosciences, University of New England, Biddeford, ME 04005, USA Electronic address
    J Neuroimmunol 269:44-51. 2014
    ..infection of the central nervous system, we applied chronic morphine treatment to the LP-BM5 murine acquired immunodeficiency syndrome (MAIDS) model...
  45. ncbi Unique CD4(+) T cells in TCR alpha chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process
    R J Hayashi
    Center for Immunology, and Departments of Pediatrics and Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int Immunol 11:1581-90. 1999
    ..These mice developed the murine acquired immunodeficiency syndrome (MAIDS) after infection with LP-BM5 retroviruses, a process which requires CD4(+) T cells...
  46. ncbi Murine cytomegalovirus retinitis during MAIDS: Susceptibility correlates with elevated intraocular levels of interleukin-4 mRNA
    Richard Dix
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Curr Eye Res 26:211-7. 2003
    To determine if murine cytomegalovirus (MCMV)-infected eyes of mice with murine acquired immunodeficiency syndrome (MAIDS) that are destined to develop MCMV retinitis display elevated intraocular levels of interleukin-4 (IL-4) mRNA when ..
  47. ncbi Inhibition of murine AIDS by pro-glutathione (GSH) molecules
    A Fraternale
    Institute of Biological Chemistry Giorgio Fornaini, Via Saffi, 2, University of Urbino Carlo Bo, 61029 Urbino PU, Italy
    Antiviral Res 77:120-7. 2008
    ..These results show that the administration of pro-GSH molecules may favorably substitute for the use of GSH as such...
  48. ncbi Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome
    Masayuki Umemura
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    FASEB J 16:1755-63. 2002
    LP-BM5 murine leukemia virus (MuLV) infection causes murine acquired immunodeficiency syndrome (MAIDS), a disease characterized by varied functional abnormalities of immunocompetent cells...
  49. ncbi Side-stream cigarette smoke accentuates immunomodulation during murine AIDS
    Jin Zhang
    Health Promotion Science Division, College of Public Health, The University of Arizona Health Science Center, Tuscon 85724, USA
    Int Immunopharmacol 2:759-66. 2002
    ..Thus, the reduction of side-stream cigarette smoke exposure is an important health issue in AIDS patients to improve the quality and quantity of their lives...
  50. pmc Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?
    Wen Li
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Virology 360:58-71. 2007
    ..The results argue that TCR engagement is not necessary for the induction of MAIDS...
  51. ncbi Mapping of a murine AIDS virus-related proviral gene (Mrv6) in NOD/Lt mice to chromosome 14
    H Tsumura
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Mamm Genome 7:706-7. 1996
  52. pmc Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus
    C Simard
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    J Virol 71:3013-22. 1997
    ..These data confirm that the primary event in the development of MAIDS is the infection of relatively mature peripheral B cells and that CD4+ T cells are required to promote the expansion of these infected B cells...
  53. pmc Involvement of microglial CD40 in murine retrovirus-induced peripheral neuropathy
    Ling Cao
    Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04005, USA
    J Neuroimmunol 261:37-43. 2013
    B6 mice infected with LP-BM5 develop severe immunodeficiency (termed murine acquired immunodeficiency syndrome (MAIDS)) and peripheral neuropathy...
  54. ncbi Bethesda proposals for classification of lymphoid neoplasms in mice
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Blood 100:246-58. 2002
    ..The classification should facilitate communications about mouse models of human lymphoid diseases...
  55. ncbi Immunomodulatory effect of gold sodium thiomalate on murine acquired immunodeficiency syndrome
    K Yamaguchi
    Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan
    Microbiol Immunol 45:549-55. 2001
    ..Thus, GST treatment may be beneficial through a decrease in disease progression via IL-2 induction in MuLV infected mice. This may have application in human immunodeficiency virus-infected individuals...
  56. ncbi In vivo examination of hydroxyurea and the novel ribonucleotide reductase inhibitors trimidox and didox in combination with the reverse transcriptase inhibitor abacavir: suppression of retrovirus-induced immunodeficiency disease
    L Ryan Sumpter
    Department of Clinical Sciences, University of Kentucky Medical Center, CHS Building, 900 South Limestone Street, Lexington, KY 40536, USA
    Antiviral Res 62:111-20. 2004
    ..In this study, all RRIs tested showed the ability to improve the efficacy of ABC in the MAIDS model by reducing splenomegaly, hypergammaglobulinemia, and splenic proviral DNA levels...
  57. pmc T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection
    Manohar B Mutnal
    Neuroimmunology Laboratory, Center for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, 3 220 LRB MTRF, 2001 6th Street S E, Minneapolis, MN 55455, USA
    J Neuroinflammation 10:98. 2013
    ..In resource-poor settings, 25% of patients receiving HAART may develop CNS-related immune reconstitution inflammatory syndrome (IRIS). Here we describe a reliable mouse model to study underlying immunopathological mechanisms of CNS-IRIS...
  58. ncbi Chemical sympathectomy has no effect on the severity of murine AIDS: murine AIDS alone depletes norepinephrine levels in infected spleen
    Sheila P Kelley
    Center for Psychoneuroimmunology Research, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, New York 14642, USA
    Brain Behav Immun 16:118-39. 2002
    ..This finding has not been previously reported in mice with MAIDS and suggests that the viral infection itself produces a functional sympathectomy in the spleen, a target of that infection...
  59. ncbi Effects of Z-100, a Mycobacterium-tuberculosis-derived arabinomannan, on the LP-BM5 murine leukemia virus infection in mice
    H Sasaki
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0435, USA
    Pathobiology 69:96-103. 2001
    ..CONCLUSION: Z-100 could decrease the severity of the LP-BM5 MuLV infection through the regulation of MAIDS-associated type-2 T-cell responses...
  60. ncbi Defective T cell receptor-mediated signaling and differential induction of T cell functions by murine AIDS virus superantigen
    O Kanagawa
    Department of Pathology and Medicine, Washington University School of Medicine, St Louis, MO 63110
    J Immunol 150:1865-72. 1993
    ..This different signaling by viral superantigen may be important for the development of viral pathogenesis in vivo...
  61. pmc Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Immunology 87:467-74. 1996
    ..These studies suggest that continuing low-level expression of IFN-gamma, stimulated by IL-12 and TNF-alpha, contributes to the susceptibility of B6 mice to MAIDS but is not required for the resistance of BALB/c mice to disease...
  62. pmc A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice
    Philip H Jones
    Department of Microbiology, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Retrovirology 9:50. 2012
    ..In this present study, we used APOBEC3 knockout mice and their wild type counterpart to query the role of APOBEC3 in sexual transmission of LP-BM5 MLV - the etiological agent of murine AIDs (mAIDs)...
  63. ncbi An immunochemical focus assay to quantify replication competent and defective viruses involved in murine acquired immunodeficiency syndrome
    A W Hugin
    Department of Dermatology, University Hospital, Geneva, Switzerland
    J Virol Methods 77:217-24. 1999
    b>Murine acquired immunodeficiency syndrome is a lymphoproliferative disease with a concurrently developing immunodeficiency...
  64. ncbi Liposomes as carriers of the antiretroviral agent dideoxycytidine-5'-triphosphate
    C Oussoren
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Int J Pharm 180:261-70. 1999
    ..Results obtained with liposome encapsulated ddCTP in the murine acquired immunodeficiency syndrome (MAIDS) model indicate that ddCTP encapsulated in liposomes can reduce proviral DNA in cells of ..
  65. ncbi The encephalopathy associated with murine acquired immunodeficiency syndrome
    Y Sei
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 840:822-34. 1998
    ....
  66. pmc Dissociation between lymphoproliferative responses and virus replication in mice with different sensitivities to retrovirus-induced immunodeficiency
    J M Pozsgay
    Oncology Center, Johns Hopkins University, Baltimore, Maryland 21205
    J Virol 67:980-8. 1993
    ..However, initial responses to virus infection such as proliferation of spleen cells and response to mitogen are similar in both strains of mice and are therefore not necessarily related to the development of the disease...
  67. pmc Murine immunodeficiency virus-induced peripheral neuropathy and the associated cytokine responses
    Ling Cao
    Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA
    J Immunol 189:3724-33. 2012
    ..Further investigation of this model could give a better understanding of, and lead to more effective treatments for, HIV infection-associated painful peripheral neuropathy...
  68. ncbi Kinetic analysis of the development of pancreatic lesions in mice infected with a murine retrovirus
    Shiro Watanabe
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Immunol 109:212-23. 2003
    ..Thus, MAIDS mice could be valuable for analyzing the pathogenesis of autoimmune-related pancreatitis associated with SjS...
  69. pmc Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
    Souad Rahmouni
    Department of Pathology, University of Liege, B 4000 Liege, Belgium
    Biochem J 384:469-76. 2004
    ..Treatment with cyclo-oxygenase type 2 inhibitors reduces the level of PGE2 and thereby reverses the T-cell anergy, restores the T-cell immune function and ameliorates the lymphoproliferative disease...
  70. ncbi Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA
    Richard D Dix
    Harvery and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Antiviral Res 59:111-9. 2003
    ..Our findings support the hypothesis that systemic IL-2 immunotherapy during MAIDS provides protection against MCMV retinitis by upregulation of perforin-mediated cytotoxicity used by cytotoxic lymphocytes to kill virus-infected cells...
  71. ncbi Cardiomyopathy in a murine model of AIDS: evidence of reactive nitrogen species and corroboration in human HIV/AIDS cardiac tissues
    Alysia A Chaves
    Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Cardiovasc Res 60:108-18. 2003
    ..Here we investigated mechanisms in retrovirus associated cardiomyopathy using a well-defined mouse model of acquired immunodeficiency...
  72. ncbi Effect of bovine lactoferrin on a transmissible AIDS-like disease in mice
    E Lubashevsky
    Department of Immunology, Kimron Veterinary Institute, Beit Dagan 50250, Israel
    Comp Immunol Microbiol Infect Dis 27:181-9. 2004
    ..It seems that bLF had played a preventive role for a restricted period of time. However, an adverse response was elicited when bLF was administered 20 days after viral infection...
  73. pmc CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency
    Kathy A Green
    Department of Microbiology and Immunology, 1 Medical Center Dr, Dartmouth Medical School, Lebanon, NH 03750, USA
    J Virol 78:6055-60. 2004
    ..We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site...
  74. pmc Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine
    Christine L Clouser
    Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 6:e15840. 2011
    ..These observations together with a recent ex vivo study with HIV-1, suggest that gemcitabine has broad antiretroviral activity and could be particularly useful in vivo when used in combination drug therapy...
  75. pmc Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Pathol 221:106-16. 2010
    ..Published in 2010 by John Wiley & Sons, Ltd...
  76. ncbi Effect of macrophage depletion on viral DNA rebound following antiretroviral therapy in a murine model of AIDS (MAIDS)
    S Serafini
    Institute of Biological Chemistry G Fornaini, University of Urbino, Via Saffi, 2 61029 Urbino PU, Italy
    Antiviral Res 81:93-102. 2009
    ..After this time, the BM5d DNA content in blood leukocytes increased in all groups, but the group having received clodronate-loaded erythrocytes, in addition to transcriptase inhibitors, showed a significant delay in viral rebound...
  77. ncbi MAIDS resistance-associated gene expression patterns in secondary lymphoid organs
    Suprawee Tepsuporn
    Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, USA
    Immunogenetics 60:485-94. 2008
    b>Murine acquired immunodeficiency syndrome (MAIDS) is caused by exposure to murine leukemia virus and serves as a model to study human AIDS...
  78. ncbi Changes in neuronal protein expression in LP-BM5-infected mice
    Kanako Takahashi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Japan
    Neurosci Lett 422:114-8. 2007
    b>Murine acquired immunodeficiency syndrome (MAIDS) induced by LP-BM5 murine leukemia virus is used as a model of human immunodeficiency virus (HIV)-related neurologic dysfunction. Mice infected with LP-BM5 have mnemonic abnormalities (i.e...
  79. ncbi Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells
    Kenji Suzuki
    Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Pathol Int 57:413-20. 2007
    ....
  80. pmc Role of a cytotoxic-T-lymphocyte epitope-defined, alternative gag open reading frame in the pathogenesis of a murine retrovirus-induced immunodeficiency syndrome
    Arti Gaur
    Department of Microbiology and Immunology, Norris Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Virol 79:4308-15. 2005
    ..Our data strongly suggest the existence of a novel ORF2 product(s) that is required for LP-BM5-induced pathogenesis and have potentially broad implications for other retroviral diseases...
  81. ncbi Dilated cardiomyopathy in retrovirally infected mice: a novel model for silent viral DCM?
    Julie Beischel
    Sarver Heart Center, Tucson, AZ 85724, USA
    Cardiovasc Toxicol 4:317-25. 2004
    ..These findings support MAIDS retroviral infection as a new model of idiopathic DCM in which myo-carditis does not occur...
  82. ncbi Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma
    Richard D Dix
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Curr Eye Res 29:173-80. 2004
    ..TNF-alpha) and interferon-gamma (IFN-gamma) synthesis with histopathologic disease and virus replication within murine cytomegalovirus (MCMV)-infected eyes during progression of murine acquired immunodeficiency syndrome (MAIDS).
  83. ncbi Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency
    Randi Mosenden
    The Biotechnology Center of Oslo, University of Oslo, N 0317 Oslo, Norway
    J Immunol 186:5119-30. 2011
    ..This underscores the cAMP-type I PKA pathway in T cells as a putative target for therapeutic intervention in immunodeficiency diseases...
  84. ncbi Central nervous system infection in a murine retrovirus-induced immunodeficiency syndrome
    Y Sei
    Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 20892
    J Neuroimmunol 37:131-40. 1992
    ....
  85. ncbi Studies on the effect of CL 306,293, a substituted quinoline carboxylic acid, on the clinical disease induced in mice with LP-BM5 virus
    J W Scott
    Oncology, and Immunology Research Section, American Cyanamid Company, Lederle Laboratories, Pearl River, NY 10965
    Antiviral Res 20:71-81. 1993
    ..CL 306,293 was more efficacious and potent than 3'-azido-3'-deoxythymidine. The beneficial effects of CL 306,293 observed in this model are most probably related to its antiproliferative properties...
  86. ncbi Toxoplasma gondii: induction of toxoplasmic encephalitis in mice with chronic infection by inoculation of a murine leukemia virus inducing immunodeficiency
    H Watanabe
    Department of Immunology, Niigata University School of Medicine, Japan
    Exp Parasitol 76:39-45. 1993
    ..Mice chronically infected with T. gondii and challenged with LP-BM5 MuLV appears to provide a good animal model of toxoplasmic encephalitis which is a major cause of morbidity and mortality in AIDS patients...
  87. ncbi Altered brain fyn kinase in a murine acquired immunodeficiency syndrome
    Y Sei
    Laboratory of Neuroscience, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 10:339-44. 1996
    ..These findings suggest that virus-associated disruption of fyn kinase-mediated signaling contributes to the cognitive deficits observed in mice with MAIDS and other retrovirus-induced encephalopathies...
  88. pmc Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS
    Y Yoshikai
    Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan
    J Virol 71:746-9. 1997
    ..MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells...
  89. ncbi The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome
    F Numata
    Department of Immunology, University of Tokyo, Japan
    Int Immunol 9:139-46. 1997
    Infection of C57BL/6 mice with LP-BM5 murine leukemia virus (MuLV) leads to the development of murine acquired immunodeficiency syndrome (MAIDS) characterized by abnormal lymphoproliferation, hypergammaglobulinemia and severe ..
  90. ncbi Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS
    Y Sei
    Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Pharmacol 325:81-4. 1997
    ..62; P < 0.01). This study demonstrates that pentoxifylline treatment was effective in decreasing the levels of TNF-alpha in the serum and PAF levels in the brain of mice infected with the LP-BM5 MuLV...
  91. pmc Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehydroepiandrosterone sulphate (DHEAS)
    M Araghi-Niknam
    Arizona Prevention Center, University of Arizona, Tucson 85724, USA
    Immunology 90:344-9. 1997
    ..Thus immune dysfunction induced by ageing, even when exacerbated by murine retrovirus infection, was largely prevented by DHEAS...
  92. ncbi Effect of blood substitute, recombinant hemoglobin, on in vivo hematopoietic recovery from AZT toxicity
    S Moqattash
    Department of Human and Clinical Anatomy, Sultan Qaboos University College of Medicine, Muscat, Oman
    Acta Haematol 98:76-82. 1997
    ....
  93. ncbi Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS)
    O Kanagawa
    Department of Pathology and Medicine, Washington University School of Medicine, St Louis, MO 63110
    Science 262:240-2. 1993
    The murine acquired immunodeficiency syndrome (MAIDS) is induced by a defective murine leukemia virus and has many symptoms similar to those found in patients infected with the human immunodeficiency virus...
  94. ncbi Influence of H-2 class II antigens on the development of murine AIDS
    M Makino
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 152:4157-64. 1994
    ..E alpha d-mediated resistance to MAIDS was associated with decreased levels of the BM5def genome in splenic DNA, suggesting that E alpha genes exert their effect by enhancing antiviral activity...
  95. ncbi Biological activity of diethyldithiocarbamate (Ditiocarb, Imuthiol) in an animal model of retrovirus-induced immunodeficiency disease and in clinical trials in patients with HIV infection. The Ditiocarb Study Group
    E M Hersh
    Department of Internal Medicine, University of Arizona Health Sciences Center, Tucson 85724
    Dev Biol Stand 72:355-63. 1990
    ..Statistically significant reductions in these events were seen in ARC patients, AIDS patients and all patients.(ABSTRACT TRUNCATED AT 250 WORDS)..
  96. ncbi Thymus involvement in murine acquired immunodeficiency (MAIDS)
    S Colombi
    Laboratory of Pathology, University of Liege, Belgium
    Thymus 23:27-37. 1994
    ..Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ...
  97. ncbi Contribution of B cell subsets to delayed development of MAIDS in xid mice
    Y Tang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Immunol 165:1-6. 1995
    ..Both sets of recipients developed advanced disease by 10 weeks post infection, suggesting that resistance to MAIDS in xid mutants may be due to effects of B cells other than the CD5+ subset...
  98. ncbi Sequence heterogeneity of murine acquired immunodeficiency syndrome virus: the role of endogenous virus
    S Gayama
    Department of Pathology and Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Int Immunol 7:861-8. 1995
    A defective murine leukemia virus is the causative agent of murine acquired immunodeficiency syndrome (MAIDS)...
  99. ncbi Rapid development of murine AIDS is dependent of signals provided by CD54 and CD11a
    M Makino
    Department of Bacterial and Blood Products, National Institute of Health Japan, Tokyo
    J Immunol 155:974-81. 1995
    ..These results suggest that the CD54/CD11a signal transduction pathway is a critical determinant of MAIDS development, and the lack of an immune response against viral Ag is enough to suppress BM5def replication and to prevent MAIDS...
  100. ncbi Impact of MHC class I gene on resistance to murine AIDS
    M Makino
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA
    Scand J Immunol 42:368-72. 1995
    ..A(18R) mice. These results suggest that the MAIDS resistance associated with the D end loci is dependent on the level of expression of an MHC class I gene...
  101. ncbi A p12 gag gene homologue is present in the mouse genome
    A Casabianca
    Institute of Biological Chemistry G Fornaini, University of Urbino, Italy
    Biochem Mol Biol Int 32:691-6. 1994
    ....

Research Grants3

  1. IMMUNOMODULATION OF RETROVIRAL CARDIOPATHOLOGY
    RONALD WATSON; Fiscal Year: 2001
    ..The treatments that found to prevent cytokine dysregulation and cardiotoxicitiy in retrovirally infected mice will then be applicable to reducing heart disease in HIV infected patients (End of Abstract) ..
  2. ROLE OF AUTOREACTIVE T CELLS IN MURINE AIDS
    Mohan Sopori; Fiscal Year: 1993
    In the murine acquired immunodeficiency syndrome (MAIDS), an animal model, in certain aspects, for AIDS, C57BL/6 mice are infected with a mixture of ecotropic and replication defective murine leukemia virus strains...
  3. ALCOHOL INDUCED IMMUNOMODULATION--RETROVIRAL CARDIOPATH
    RONALD WATSON; Fiscal Year: 2003
    ..Such studies could provide the basis for their application to reduce heart disease in alcohol-abusing, HIV-infected patients. ..