tumor virus infections

Summary

Summary: Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.

Top Publications

  1. ncbi Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
  2. pmc Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
  3. ncbi Seroprevalence of human polyomavirus 9 and cross-reactivity to African green monkey-derived lymphotropic polyomavirus
    Franziska Trusch
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    J Gen Virol 93:698-705. 2012
  4. pmc A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus
    Nelly Scuda
    Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 85:4586-90. 2011
  5. ncbi Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Vincent C Lombardi
    Whittemore Peterson Institute, Reno, NV 89557, USA
    Science 326:585-9. 2009
  6. ncbi Human polyomaviruses in disease and cancer
    Tina Dalianis
    Department of Oncology Pathology, Karolinska Institutet, Cancer Center Karolinska R8 01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Virology 437:63-72. 2013
  7. pmc African great apes are naturally infected with polyomaviruses closely related to Merkel cell polyomavirus
    Fabian H Leendertz
    Research Group Emerging Zoonoses, Robert Koch Institute, Berlin, Germany
    J Virol 85:916-24. 2011
  8. ncbi Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study
    C B Woodman
    Centre for Cancer Epidemiology, University of Manchester, Withington, M20 4QL, Manchester, UK
    Lancet 357:1831-6. 2001
  9. pmc MCV and Merkel cell carcinoma: a molecular success story
    Reety Arora
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States
    Curr Opin Virol 2:489-98. 2012
  10. pmc Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood
    Jayasri G Iyer
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98109, USA
    Clin Cancer Res 17:6671-80. 2011

Research Grants

  1. Immune Response to Polyomavirus Infection
    Parmjeet S Randhawa; Fiscal Year: 2010
  2. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2008
  3. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
  4. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2003
  5. Regulation of Polyoma Virus-Specific CD8+ T Cells
    ARON LUKACHER; Fiscal Year: 2007
  6. Antiviral Therapy for Polyomavirus Infection
    ARON LUKACHER; Fiscal Year: 2008
  7. SV40 Pathogenesis of Human Infections
    JANET BUTEL; Fiscal Year: 2008
  8. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
  9. Hamster Model for AIDS Lymphomas
    JANET BUTEL; Fiscal Year: 2003
  10. RANDOMIZED TRIAL OF BREAST SELF EXAMINATION IN SHANGHAI
    David Thomas; Fiscal Year: 2001

Detail Information

Publications284 found, 100 shown here

  1. ncbi Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
    ..To hasten the reduction of HPV-16 prevalence in the population, widespread vaccination of adolescent and young adult males should also be considered...
  2. pmc Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
    ..Thus, MCV may be a contributing factor in the pathogenesis of MCC...
  3. ncbi Seroprevalence of human polyomavirus 9 and cross-reactivity to African green monkey-derived lymphotropic polyomavirus
    Franziska Trusch
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    J Gen Virol 93:698-705. 2012
    ....
  4. pmc A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus
    Nelly Scuda
    Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 85:4586-90. 2011
    ..The virus was tentatively named human polyomavirus 9 (HPyV9). The previously observed seroreactivity to LPV in human populations might find a partial explanation in the circulation of HPyV9...
  5. ncbi Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Vincent C Lombardi
    Whittemore Peterson Institute, Reno, NV 89557, USA
    Science 326:585-9. 2009
    ..These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS...
  6. ncbi Human polyomaviruses in disease and cancer
    Tina Dalianis
    Department of Oncology Pathology, Karolinska Institutet, Cancer Center Karolinska R8 01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Virology 437:63-72. 2013
    ..The discovery of the new HPyVs has revived interest in the Polyomaviridae and their association to human disease and cancer. In this review, we summarize knowledge about this expanding family of human pathogens...
  7. pmc African great apes are naturally infected with polyomaviruses closely related to Merkel cell polyomavirus
    Fabian H Leendertz
    Research Group Emerging Zoonoses, Robert Koch Institute, Berlin, Germany
    J Virol 85:916-24. 2011
    ..This, together with the fact that humans in West and Central Africa frequently hunt and butcher primates, may point toward further MCPyV-like strains spreading to, or already existing in, our species...
  8. ncbi Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study
    C B Woodman
    Centre for Cancer Epidemiology, University of Manchester, Withington, M20 4QL, Manchester, UK
    Lancet 357:1831-6. 2001
    ..We studied the natural history of incident cervical HPV infection and its relation to the development of CIN...
  9. pmc MCV and Merkel cell carcinoma: a molecular success story
    Reety Arora
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States
    Curr Opin Virol 2:489-98. 2012
    ..In four years, the cause, diagnosis and therapy for an intractable cancer has been changed due to the molecular discovery of MCV...
  10. pmc Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood
    Jayasri G Iyer
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98109, USA
    Clin Cancer Res 17:6671-80. 2011
    ..We sought to characterize T-cell responses directed against viral proteins that drive this cancer as a step toward immunotherapy...
  11. ncbi Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  12. ncbi HPV-associated head and neck cancer: a virus-related cancer epidemic
    Shanthi Marur
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Lancet Oncol 11:781-9. 2010
    ....
  13. ncbi Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients
    Hans H Hirsch
    Division of Infectious Diseases, University of Basel, Basel, Switzerland
    N Engl J Med 347:488-96. 2002
    ....
  14. ncbi Polyomavirus BK
    Hans H Hirsch
    Division of Infectious Diseases, Department of Internal Medicine, University Hospitals Basel, and Transplantation Virology Laboratory, Institute of Medical Microbiology, University of Basel, Switzerland
    Lancet Infect Dis 3:611-23. 2003
    ..Case series suggest that cidofovir might be effective, especially when combined with reduced immunosuppression...
  15. pmc Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 82:408-18. 2008
    ..Coinfection of mice with LDV and FV provides a well-defined, natural host model for such studies...
  16. pmc Identification of a third human polyomavirus
    Tobias Allander
    Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Virol 81:4130-6. 2007
    ..This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types...
  17. pmc BK virus and human cancer: innocent until proven guilty
    Johanna R Abend
    Department of Microbiology and Immunology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 5620, USA
    Semin Cancer Biol 19:252-60. 2009
    ..Due to the lack of conclusive causality data from these studies, there does not appear to be a definitive association between BKV and human cancers...
  18. pmc Frequent detection of polyomaviruses in stool samples from hospitalized children
    John A Vanchiere
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 192:658-64. 2005
    ..Conclusions. Polyomaviruses are frequently present in stool samples from hospitalized children. These findings suggest that fecal-oral transmission of BKV may play a role in the ubiquity of infection...
  19. ncbi Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors
    Cecilia Pancaldi
    Department of Morphology and Embryology, Section of Cell Biology and Molecular Genetics, University of Ferrara, Ferrara, Italy and
    Blood 117:7099-101. 2011
    ....
  20. ncbi Trichodysplasia spinulosa is characterized by active polyomavirus infection
    Siamaque Kazem
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Virol 53:225-30. 2012
    ..Seroepidemiological studies indicate that TSPyV is ubiquitous and latently infects 70% of the healthy individuals...
  21. ncbi Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:46-52. 2003
    ..We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer...
  22. ncbi Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4
    P G Stevenson
    Division of Virology, Department of Pathology, University of Cambridge, UK
    J Gen Virol 90:2317-30. 2009
    ..Reducing the infectivity of herpesvirus carriers in this way could be a useful adjunct to vaccinating naive individuals with attenuated mutants...
  23. ncbi Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction
    Daniel C Brennan
    Washington University School of Medicine, Department of Internal Medicine, St Louis, Missouri, USA
    Am J Transplant 5:582-94. 2005
    ..Viruria was highest with FK506-MMF and lowest with CyA-MMF. Monitoring and preemptive withdrawal of immunosuppression were associated with resolution of viremia and absence of BK nephropathy without acute rejection or graft loss...
  24. ncbi 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
    JAMA 287:2120-9. 2002
    ..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors...
  25. pmc Age-specific seroprevalence of Merkel cell polyomavirus, BK virus, and JC virus
    Raphael P Viscidi
    Department of Pediatrics, The Johns Hopkins Hospital, Blalock 1153, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Vaccine Immunol 18:1737-43. 2011
    ..In agreement with results from other studies, we found an association between MCPyV seropositivity and MCC, and higher levels of serum MCPyV capsid antibodies in MCC patients than in controls...
  26. ncbi Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus
    Tingting Chen
    Department of Virology, Haartman Institute, Finland
    J Infect Dis 204:1523-6. 2011
    ..TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years...
  27. ncbi Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
    Marc Arbyn
    European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
    J Natl Cancer Inst 96:280-93. 2004
    ..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
  28. pmc HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Cancer 84:1219-26. 2001
    ..Among HPV-positive women, multiparity and smoking are risk factors for HSIL/CA. Oral contraceptive use may be associated with HSIL/CA in subgroups of women...
  29. ncbi Human polyomaviruses and other human viruses in neuroendocrine tumors
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:1558-61. 2011
    ....
  30. ncbi Mammalian target of rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients
    A I Sanchez Fructuoso
    Department of Nephrology, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transpl Infect Dis 13:584-91. 2011
    ..Furthermore, target levels of immunosuppressive drugs are poorly defined, as are criteria for replacing one immunosuppressive agent with another...
  31. ncbi From Stockholm to Malawi: recent developments in studying human polyomaviruses
    Mariet C W Feltkamp
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Gen Virol 94:482-96. 2013
    ..This review summarizes the recent developments in studying the novel human polyomaviruses, and touches upon several aspects of polyomavirus virology, pathogenicity, epidemiology and phylogeny...
  32. ncbi Serological evidence of vertical transmission of JC and BK polyomaviruses in humans
    Renzo Boldorini
    Department of Medical Sciences, Faculty of Medicine, University Amedeo Avogadro of the Eastern Piedmont, Novara, Italy
    J Gen Virol 92:1044-50. 2011
    ..These results suggest JC virus and BK virus can be transmitted from mother to newborn during pregnancy or soon after birth...
  33. ncbi Human papillomavirus and the long-term risk of cervical neoplasia
    Yolanda van der Graaf
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Epidemiol 156:158-64. 2002
    ..3, 35.7) for HPV positivity in general, 5.4 (95% CI: 1.5, 19.5) for infection with low-risk HPV genotypes, 24.0 (95% CI: 12.4, 46.4) for high-risk HPV genotypes, and 104.8 (95% CI: 29.5, 372.7) for HPV type 16...
  34. ncbi JC virus-associated nephropathy in a renal transplant recipient and comparative analysis of previous cases
    G Kantarci
    Department of Nephrology, Yeditepe University, Istanbul, Turkey
    Transpl Infect Dis 13:89-92. 2011
    ....
  35. ncbi BK virus: opportunity makes a pathogen
    Hans H Hirsch
    Department of Clinical Biological Sciences, University of Basel, University Hospital Basel, Basel, Switzerland
    Clin Infect Dis 41:354-60. 2005
    ..This article discusses current views of pathogenesis, diagnosis, and treatment...
  36. pmc Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:4645-53. 2012
    ..These results indicate that MCPyV is present in MCC tumors more frequently than previously reported and that mutations in TP53 tend to occur in MCC tumors that fail to express MCPyV large T antigen...
  37. ncbi Polyomavirus infection in a free-ranging California sea lion (Zalophus californianus) with intestinal T-cell lymphoma
    Kathleen M Colegrove
    Zoological Pathology Program, University of Illinois, Loyola University Medical Center, Building 101, Room 0745, 2160 South First Avenue, Maywood, IL 60153, USA
    J Vet Diagn Invest 22:628-32. 2010
    ..The relationship, if any, between polyomavirus infection and the other disease processes in this sea lion is not known, but it is considered unlikely that the polyomavirus induced the lymphoma...
  38. ncbi Prevalence and stability of human serum antibodies to simian virus 40 VP1 virus-like particles
    Annika Lundstig
    Department of Medical Microbiology, Malmo University Hospital, Entrance 78, 20502 Malmo, Sweden
    J Gen Virol 86:1703-8. 2005
    ..In conclusion, there is a low prevalence of SV40-specific antibodies in the Nordic population. The SV40 antibodies appear to have a low stability over time and their origin is not clear...
  39. ncbi Case-control study of Merkel cell polyomavirus infection and cutaneous squamous cell carcinoma
    Dana E Rollison
    Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33647, USA
    Cancer Epidemiol Biomarkers Prev 21:74-81. 2012
    ..Merkel cell polyomavirus (MCV) DNA has been reported in 0% to 25% of squamous cell carcinomas (SCC) occurring in immunocompetent individuals. We conducted the first serologic case-control study of MCV and SCC...
  40. ncbi Next-generation sequencing for simultaneous determination of human papillomavirus load, subtype, and associated genomic copy number changes in tumors
    Caroline Conway
    Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    J Mol Diagn 14:104-11. 2012
    ..Thus, the use of next-generation sequencing for the detection of HPV provides a multiplicity of data with clinical significance in a single test...
  41. pmc The DNA damage response in viral-induced cellular transformation
    P A Nikitin
    Department of Molecular Genetics and Microbiology, Center for Virology, Duke University Medical Center, 213 Research Dr, CARL 424, DUMC 3054, Durham, NC 27710, USA
    Br J Cancer 106:429-35. 2012
    ..This review will focus on the interplay between oncogenic viruses and the DDR with respect to cellular checkpoint control and transformation...
  42. ncbi Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women
    L Ahdieh
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 184:682-90. 2001
    ..9 (95% CI, 1.5-2.3) times greater if the subject had a CD4 cell count <200 cells/microL (vs. >500 cells/microL). Thus, HIV infection and immunosuppression play an important role in modulating the natural history of HPV infection...
  43. pmc A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences
    William Lowther
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Virol 79:10093-6. 2005
    ..Reverse transcriptase PCR results demonstrated that each of the viral insertions led to elevated expression of the presumed target flanking genes...
  44. pmc BK polyomavirus: emerging pathogen
    Shauna M Bennett
    Program in Cellular and Molecular Biology, University of Michigan Medical School, 1150 West Medical Center Drive, 5724 Medical Science II, Ann Arbor, MI 48109 5620, USA
    Microbes Infect 14:672-83. 2012
    ..In this review, we discuss the clinical relevance, effects on the host, virus life cycle, and current treatment protocols...
  45. ncbi History and current concepts in the pathogenesis of PML
    Eugene O Major
    Laboratory of Molecular Medicine and Neuroscience, NINDS, Building 10, Room 3B14, 10 Center Drive, MSC 1296, Bethesda, MD 20892 1296, USA
    Cleve Clin J Med 78:S3-7. 2011
    ..The emergence of PML in patients treated with natalizumab and other immune-altering agents supports this observation and provides new insights into the pathogenic mechanisms of JCV infection...
  46. ncbi Presence, quantitation and characterization of JC virus in the urine of Italian immunocompetent subjects
    Andrea Rossi
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation ONLUS, IRCCS, Milano, Italy
    J Med Virol 79:408-12. 2007
    ..The lack of correlation between JCV DNA detection and the presence of squamous cells in urine sediment indicates that viruria is regulated by the life cycle of JCV. Thus, the virus is eliminated as consequence of its reactivation...
  47. pmc A comparative study of Merkel cell, BK and JC polyomavirus infections in renal transplant recipients and healthy subjects
    Mohamed I Husseiny
    Division of Translational Vaccine Research, Department of Virology, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3000, USA
    J Clin Virol 49:137-40. 2010
    ..Merkel cell carcinoma (MCC) is a rare skin cancer associated with immunosuppression and the integration of Merkel cell polyomavirus (MCPyV) DNA into the tumor cell genome. Little is known about the natural history of MCPyV infection...
  48. pmc Asymptomatic primary Merkel cell polyomavirus infection among adults
    Yanis L Tolstov
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 17:1371-80. 2011
    ..In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations...
  49. ncbi The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women
    Y W Cheng
    Institute of Medicine, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
    Cancer Res 61:2799-803. 2001
    ..The high prevalence of HPV 16/18 infection may explain to a certain extent why Taiwanese women nonsmokers had a higher lung cancer mortality rate...
  50. pmc Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas
    Klaus J Busam
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Surg Pathol 33:1378-85. 2009
    ..It labels the majority of MCCs, but fails to react with pulmonary neuroendocrine carcinomas. We also found that neuroendocrine carcinomas of the skin arising in association with a squamous cell carcinoma seem to be independent of MCV...
  51. pmc Murid herpesvirus-4 exploits dendritic cells to infect B cells
    Miguel Gaspar
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Pathog 7:e1002346. 2011
    ..In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells...
  52. ncbi Genotypes of JC virus in East, Central and Southwest Europe
    H T Agostini
    Department of Ophthalmology, University of Freiburg, Killianstr. 5, 79106 Freiburg, Germany
    J Gen Virol 82:1221-331. 2001
    ..Interestingly, neither the Gitanos in Spain, nor Sinti or Roma in Germany or Hungary showed the Type 2 or Type 7 genotype that might be expected if their origins were in an Asian population...
  53. ncbi Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  54. ncbi Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study
    Rolando Herrero
    International Agency for Research on Cancer, Lyon, France rherrero amnet co cr
    J Natl Cancer Inst 95:1772-83. 2003
    ..To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries...
  55. ncbi Update on human polyomaviruses and cancer
    Ole Gjoerup
    Cancer Virology Program, Hillman Cancer Research Pavilion, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Adv Cancer Res 106:1-51. 2010
    ..We further present a discussion on advances made in SV40 as the prototypic model, which has and will continue to inform our understanding about viruses and cancer...
  56. pmc The role of polyomaviruses in human disease
    Mengxi Jiang
    Department of Microbiology and Immunology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, 48109, USA
    Virology 384:266-73. 2009
    ..This review describes the general aspects of human polyomavirus infections and pathogenicity. Current topics of investigation and future directions in the field are also discussed...
  57. pmc Seroprevalence of trichodysplasia spinulosa-associated polyomavirus
    Els van der Meijden
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Emerg Infect Dis 17:1355-63. 2011
    ..In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age...
  58. ncbi HIV-associated lymphomas and gamma-herpesviruses
    Antonino Carbone
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy
    Blood 113:1213-24. 2009
    ....
  59. ncbi Prevalence and stability of antibodies to the BK and JC polyomaviruses: a long-term longitudinal study of Australians
    Annika Antonsson
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Gen Virol 91:1849-53. 2010
    ..Thus, a single measure can be used as a reasonable indicator of long-term antibody status in epidemiological studies aiming to understand associations between polyomaviruses and disease...
  60. ncbi Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma
    Harri Sihto
    Laboratory of Molecular Oncology, Biomedicum Helsinki, Finland
    Clin Cancer Res 17:4806-13. 2011
    ..Polyomaviruses repress tumor suppressor proteins, thus influencing cell-cycle progression, but the effect of MCPyV on the key cell-cycle regulating proteins is poorly understood...
  61. ncbi Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein
    Virginie Sandrin
    INSERM U412, Lyon Ecole Normale Supérieure de Lyon, and IFR128 BioSciences Lyon Gerland, Lyon, F 69007 France
    J Biol Chem 281:528-42. 2006
    ..Finally, the expression of Nef proteins specifically enhanced the incorporation of the retroviral GPs by increasing their localization in late endosomes...
  62. pmc Human polyomavirus related to African green monkey lymphotropic polyomavirus
    Virginie Sauvage
    Institut Pasteur, Paris, France
    Emerg Infect Dis 17:1364-70. 2011
    ..These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders...
  63. ncbi BK virus nephritis after renal transplantation
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 69:655-62. 2006
    ..The source of BKV infection (donor as opposed to recipient), the role of host humoral, and cellular immunity to BKV, and the role of alloimmune activation in renal graft to the occurrence of nephritis are discussed in this review...
  64. ncbi Association of human papillomavirus type 58 variant with the risk of cervical cancer
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Natl Cancer Inst 94:1249-53. 2002
    ..038, two-sided Mann-Whitney U test). Thus, HPV58 variants carrying E7 T20I/G63S substitutions may be associated with an increased risk for cervical cancer...
  65. ncbi A mouse model for infectious mononucleosis
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Res 25:201-17. 2002
    ..The focus of this article will be to highlight the similarities and differences in the infectious mononucleosis syndrome associated with human and murine gamma-herpesviruses...
  66. pmc Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2
    Xiaozhen Liang
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Virol 80:5862-74. 2006
    ..Our results suggest that gammaHV68 M2 blocks apoptosis-mediated intracellular innate immunity, which might ultimately contribute to its role in latent infection...
  67. pmc Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
    ..Our study demonstrates that MCV is a widespread but previously unrecognized human infection...
  68. pmc Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 72:6554-8. 1998
    ..The results indicated that immune mechanisms rather than viral interference mediated protection...
  69. pmc Potential transmission of human polyomaviruses through the gastrointestinal tract after exposure to virions or viral DNA
    S Bofill-Mas
    Department of Microbiology, Biology School, University of Barcelona, Barcelona 08028, Catalonia, Spain
    J Virol 75:10290-9. 2001
    ..Since most humans are infected with JCV and BKV, these data indicate that the ingestion of contaminated water or food could represent a possible portal of entrance of these viruses or polyomavirus DNA into the human population...
  70. ncbi Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas
    Koen Schepers
    Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Immunol 169:3191-9. 2002
    ....
  71. ncbi Failure to detect human papillomavirus DNA in malignant epithelial neoplasms of conjunctiva by polymerase chain reaction
    Hock Liew Eng
    Department of Pathology, Kaohsiung Medical Center, Chang Gung University and Memorial Hospital, Taiwan, Republic of China
    Am J Clin Pathol 117:429-36. 2002
    ..In contrast, malignant conjunctival carcinomas are not associated with HPV infection; other pathogenic mechanisms, such as UV light, probably are more important in the cause of these malignant lesions...
  72. ncbi HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer
    T C Wright
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    JAMA 283:81-6. 2000
    ..In many other regions of the world, there is only limited access to cervical cancer screening...
  73. pmc Identification of viral infections in the prostate and evaluation of their association with cancer
    Margarita L Martinez-Fierro
    Department of Biochemistry and Molecular Medicine, University Hospital Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico
    BMC Cancer 10:326. 2010
    ..Association studies with the R462Q allele and non-XMRV viruses have not been reported. We assessed associations between prostate cancer, prostate viral infections, and the RNASEL 462Q allele in Mexican cancer patients and controls...
  74. ncbi Human papillomavirus infections and risks of cervical cancer: what do women know?
    Marian Pitts
    Australian Research Centre for Sex Health and Society, La Trobe University, 215 Franklin Street, Melbourne, Victoria 3000, Australia
    Health Educ Res 17:706-14. 2002
    ..It is essential to improve women's understanding of this area in the context of plans to include screening for HPV in the UK's national cervical screening programme...
  75. ncbi Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity
    Patrick K Ha
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:1203-9. 2002
    ....
  76. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
    ..The attributable fraction at the specific sites varies from 100% of cervix cancers attributable to the papilloma viruses to a tiny proportion (0.4%) of liver cancers (worldwide) caused by liver flukes...
  77. pmc XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberg
    Department of Pathology and Cell Biology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:16351-6. 2009
    ..Our observations provide evidence for an association of XMRV with malignant cells and with more aggressive tumors...
  78. ncbi Human papillomavirus in oral exfoliated cells and risk of head and neck cancer
    Elaine M Smith
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City 52242, USA
    J Natl Cancer Inst 96:449-55. 2004
    ....
  79. ncbi Clinical course of polyoma virus nephropathy in 67 renal transplant patients
    Emilio Ramos
    Departments of Medicine, Pathology, Pharmacy Services, and Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Soc Nephrol 13:2145-51. 2002
    ..Although multiple factors probably play a role in the development of PVN, judicious use of immunosuppressive agents is indicated to minimize the occurrence of this infection...
  80. ncbi Wildlife cancer: a conservation perspective
    Denise McAloose
    Pathology and Disease Investigation, Global Health Program, Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, New York, New York 10460, USA
    Nat Rev Cancer 9:517-26. 2009
    ..It is also clear that anthropogenic activities contribute to the development of neoplasia in wildlife species, such as beluga whales and bottom-dwelling fish, making them sensitive sentinels of disturbed environments...
  81. ncbi Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis
    H zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Natl Cancer Inst 92:690-8. 2000
    ..Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis...
  82. pmc A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusions
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 83:561-5. 2000
    ..A range of issues including the age to start and stop screening, the appropriate screening interval, the role of self-sampling for HPV testing and the choice of primary test (HPV and/or cytology) require further evaluation...
  83. pmc Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored
    David Leuenberger
    Transplantation Virology, Institute for Medical Microbiology, Department of Clinical and Biological Sciences, University of Basel, Petersplatz 10, CH 4003 Basel, Switzerland
    Clin Vaccine Immunol 14:959-68. 2007
    ..We conclude that BKV agnoprotein, though abundantly expressed in vivo, is poorly recognized immunologically...
  84. ncbi Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy
    S Schaub
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Switzerland
    Am J Transplant 10:2615-23. 2010
    ..6 mg/dl and 1.3 mg/dl, respectively. We conclude that screening for BKV-replication and reduction of immunosuppression is an effective strategy to preserve medium-term allograft function even in patients developing definitive PyVAN...
  85. ncbi Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods
    Cinthia B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Hum Pathol 36:1245-55. 2005
    ..Also discussed in the context of their clinical significance are the main virological and epidemiological aspects of the BK, JC, and SV40 polyomavirus infections...
  86. ncbi BKV-DNA and JCV-DNA in CSF of patients with suspected meningitis or encephalitis
    A Behzad-Behbahani
    Clinical Virology Section, Organ Transplantation Research Center, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Infection 31:374-8. 2003
    ..PCR-microplate hybridization method was employed for the detection of BKV-DNA or JCV-DNA in cerebrospinal fluid (CSF) specimens from patients with suspected meningitis or encephalitis...
  87. ncbi A prospective longitudinal study of polyomavirus shedding in lung-transplant recipients
    Lora D Thomas
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Infect Dis 195:442-9. 2007
    ..Polyomavirus infection causes renal dysfunction after kidney transplantation, but it has not been thoroughly investigated in nonrenal solid-organ transplantation...
  88. ncbi Association of JC virus with tubulointerstitial nephritis in a renal allograft recipient
    Mei Chin Wen
    Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan
    J Med Virol 72:675-8. 2004
    ..Molecular examination using the polymerase chain reaction (PCR) and DNA sequencing revealed that the JCV was involved in the nephritis. The results indicated that JCV may be associated with tubulointerstitial nephritis...
  89. ncbi Organogenic role of B lymphocytes in mucosal immunity
    T V Golovkina
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Science 286:1965-8. 1999
    ..The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers...
  90. ncbi HPV oligonucleotide microarray-based detection of HPV genotypes in cervical neoplastic lesions
    Chan Joo Kim
    Division of Gynecologic Oncology and Department of Obstetrics and Gynecology, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Gynecol Oncol 89:210-7. 2003
    ..In particular, we undertook the evaluation of the clinical efficacy of the HPV oligonucleotide microarray for detecting HPV in cervical neoplastic lesions...
  91. pmc BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants
    Peter H O'Donnell
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA
    Biol Blood Marrow Transplant 15:1038-1048.e1. 2009
    ..Investigation of whether prophylaxis against, or treatment of, BKV in the post-HSCT setting mitigates the associated morbidities, especially kidney injury, warrants prospective evaluation...
  92. ncbi Cervical neoplasia and repeated positivity of human papillomavirus infection in human immunodeficiency virus-seropositive and -seronegative women
    L Ahdieh
    Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 151:1148-57. 2000
    ..014) was fully explained by repeated HPV positivity induced by HIV infection (p = 0.648). Reversal of immunosuppression following potent antiretroviral therapy must be expected to have a dramatic impact on HIV-related CIN...
  93. ncbi Genome analysis of the new human polyomaviruses
    Marijke Van Ghelue
    Department of Medical Genetics, University Hospital Northern Norway, Tromsø, Norway
    Rev Med Virol 22:354-77. 2012
    ....
  94. ncbi Unique BK virus non-coding control region (NCCR) variants in hematopoietic stem cell transplant recipients with and without hemorrhagic cystitis
    Michael J Carr
    Department of Clinical Microbiology, Trinity Centre for Health Sciences, University of Dublin, Trinity College, St James s Hospital, Dublin, Ireland
    J Med Virol 78:485-93. 2006
    ..Architectural rearrangements in the NCCRs of BKV did not appear to be a prerequisite for development of hemorrhagic cystitis in hematopoietic stem cell transplant recipients...
  95. ncbi Polyomavirus polymerase chain reaction as a surrogate marker of polyomavirus-associated nephropathy
    Helen B Viscount
    Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Transplantation 84:340-5. 2007
    ..A noninvasive assay that can guide the evaluation of PVAN would be of clinical value. We compared the utility of BK virus (BKV) polymerase chain reaction (PCR) and urine cytology in screening for concurrent PVAN...
  96. ncbi Early BK polyomavirus (BKV) reactivation in donor kidney is a risk factor for development of BKV-associated nephropathy
    Baljit K Saundh
    Microbiology and Renal Unit, Leeds Teaching Hospitals NHS Trust, United Kingdom
    J Infect Dis 207:137-41. 2013
    ..Thus, early testing of urine samples from renal transplant recipients may identify those at risk for BKV-associated nephropathy...
  97. ncbi Cervical and anal HPV infections in HIV positive women and men
    Silvia de Sanjose
    Department of Epidemiology and Cancer Registry, Catalan Institute of Oncology, Gran Via Km 2 7, 08907 Hospitalet de Ll, Barcelona, Spain
    Virus Res 89:201-11. 2002
    ..Full screening for CIN remains necessary in HIV-positive women and it is likely that screening for AIN will be beneficial as well to prevent invasive anogenital cancer in long-term AIDS survivors...
  98. ncbi Papilloma and polyoma DNA tumor virus sequences in female genital tumors
    Fernanda Martini
    Department of Morphology and Embryology, Section of Histology and Embryology, School of Medicine, University of Ferrara, Ferrara, Italy
    Cancer Invest 22:697-705. 2004
    ..In addition, HPV and PYV may complement each other in infecting human genital tissues...
  99. ncbi The first case of JC virus allograft nephropathy
    Amir Kazory
    Transplantation 76:1653-5. 2003
  100. pmc Human polyoma viruses and disease with emphasis on clinical BK and JC
    Raghavender Boothpur
    Barnes Jewish Hospital, St Louis, MO, United States
    J Clin Virol 47:306-12. 2010
    ..There are no known effective antiviral agents for any of the polyoma viruses...
  101. pmc JC virus variant associated with cerebellar atrophy in a patient with AIDS
    Damien Roux
    Laboratoire de Microbiologie, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Clin Microbiol 49:2196-9. 2011
    ..Our data underline the importance of searching for JCV in HIV-infected patients with cerebellar disorders and suggest that mutations in the regulatory region may be involved in cerebellar degeneration...

Research Grants71

  1. Immune Response to Polyomavirus Infection
    Parmjeet S Randhawa; Fiscal Year: 2010
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
  2. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2008
    ..abstract_text> ..
  3. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
    ..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. [unreadable] [unreadable] [unreadable]..
  4. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2003
    ..abstract_text> ..
  5. Regulation of Polyoma Virus-Specific CD8+ T Cells
    ARON LUKACHER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. Antiviral Therapy for Polyomavirus Infection
    ARON LUKACHER; Fiscal Year: 2008
    ..g., FDA-approved Gleevec) limit polyomavirus infection, a critical prelude for their potential therapeutic use to prevent polyomavirus reactivation in immunosuppressed individuals. [unreadable] [unreadable] [unreadable]..
  7. SV40 Pathogenesis of Human Infections
    JANET BUTEL; Fiscal Year: 2008
    ..This new information will allow better understanding of the biology of SV40 human infections and may provide insights into the mechanisms of SV40 involvement in human malignancies. [unreadable] [unreadable]..
  8. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
    ..The results of these studies will enhance our understanding of the role of apoptosis in the development of neoplastic disease. ..
  9. Hamster Model for AIDS Lymphomas
    JANET BUTEL; Fiscal Year: 2003
    ..In addition, this project may provide new insights into lymphomagenesis in general and may lead to the development of new diagnostic and therapeutic approaches to this malignancy. ..
  10. RANDOMIZED TRIAL OF BREAST SELF EXAMINATION IN SHANGHAI
    David Thomas; Fiscal Year: 2001
    ..No further intervention activities are proposed. After 10 years of follow-up, over 2.6 million woman-years will have accrued, and this trial will have 80% power to detect a reduction in breast cancer mortality of 30%. ..
  11. DIET, CELL PROLIFERATION AND BREAST CANCER IN SHANGHAI
    David Thomas; Fiscal Year: 2001
    ..Also unlike prior epidemiologic studies of diet and breast cancer, in the proposed investigation the primary end points are various indices of cell proliferation. ..
  12. Polymorphisms of INS/IGF Signal Pathways & Female Cancer
    Gloria Ho; Fiscal Year: 2006
    ..This genetic study, in conjunction with the ongoing serological study, will provide a comprehensive examination of the role of the insulin/IGF system in tumorigenes ..
  13. Aspirin, Inflammation Markers, and Colorectal Adenoma
    Gloria Ho; Fiscal Year: 2006
    ..It may also identify target populations (e.g., those with high levels of proinflammatory cytokines) who may benefit most from chemoprevention of aspirin. ..
  14. Pro & Anti-Inflammatory Cytokines in Colorectal Cancer
    GLORIA YF HO; Fiscal Year: 2010
    ..These high-risk individuals may benefit from prophylactic NSAIDS for prevention of colorectal cancer. ..
  15. SPONTANEOUS REGRESSION BIOMARKERS IN CERVIX DYSPLASIA
    Gloria Ho; Fiscal Year: 2003
    ..DNA typing of class II HLA alleles by PCR will be performed using blood collected at baseline. Associations between these factors and regression of CIN will be assessed by appropriate univariate and multivariate analyses. ..
  16. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..abstract_text> ..
  17. New World Oncogenic Lymphocryptoviruses
    Frederick Wang; Fiscal Year: 2005
    ..Specific aim #3. Study the disease association, epidemiology, and evolution of New World LCV. Specific aim #4. Develop an experimental Ca1HV-3 animal model to study the pathogenesis of persistent infection and virus-induced oncogenesis. ..
  18. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
    ..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
  19. BIOMARKERS FOR ANAL CANCER
    Stephen Hawes; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  20. CHEMOTHERAPY DECISIONS AND OUTCOMES FOR THE ELDERLY
    Jeanne Mandelblatt; Fiscal Year: 2005
    ..Interventions derived from this project, hold the promise of improving the quality of care for the fastest growing segment of the breast cancer population. ..
  21. The Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne Marrazzo; Fiscal Year: 2006
    ..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
  22. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
    ..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..
  23. Human Papillovirus Testing in Adolescents
    Jessica Kahn; Fiscal Year: 2006
    ..Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls. ..
  24. EPIDEMIOLOGY OF ORAL HIV 1 & 2 INFECTION IN HIGH RISK WO
    Stephen Hawes; Fiscal Year: 2003
    ....
  25. MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTION
    Eduardo Franco; Fiscal Year: 2003
    ..abstract_text> ..
  26. Nested case-control study of JC virus infection and incident colorectal cancer
    Dana Rollison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  27. Dendritic Cells For Prevention of Islet Graft Rejection
    Karl Womer; Fiscal Year: 2008
    ..Finally, our studies will be important to the development of clinical strategies designed to prolong the survival of islet cell transplants. ..
  28. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  29. Feasibility Study of Soccer Injuries
    Melissa Schiff; Fiscal Year: 2007
    ..Findings from this research will be used to for the development of a large, prospective cohort study to evaluate potentially modifiable risk factors for injury among female youth soccer players. [unreadable] [unreadable]..
  30. Clinical & Cost Effectiveness of HPV Vaccination in the US
    Sue Goldie; Fiscal Year: 2009
    ....
  31. DIET AND DURATION OF CERVICAL HPV INFECTION
    MARC GOODMAN; Fiscal Year: 2009
    ....
  32. HPV ETIOLOGY OF A SUBSET OF HEAD AND NECK CANCERS
    Keerti Shah; Fiscal Year: 2004
    ..If HPV etiology is established for a subset of HNSCC, patients with these tumors may benefit from HPV-specific immunotherapies which are being evaluated for the treatment of invasive cervical cancer. ..
  33. REGULATION OF EBV TRANSCRIPTION IN BURKITT'S LYMPHOMA
    SAMUEL SPECK; Fiscal Year: 2009
    ....
  34. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
    ..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  35. VIRAL TRANSCRIPTION IN EBV TRANSFORMED B CELLS
    SAMUEL SPECK; Fiscal Year: 2006
    ..Aim 4. Analysis of Wp methylation during the establishment and maintenance of immortalizing latency in B cells - role of methylation in regulating Wp activity in lymphoblastoid cell lines. ..
  36. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  37. Inhibition of HIV by Novel Chimeric Receptors
    Jonathan Allan; Fiscal Year: 2004
    ..If successful, this strategy will have broad applications in immunotherapy and immune reconstitution against HIV-1. ..
  38. Leukoencephalopathy in HAART-treated HIV-1+ Patients
    Pasquale Ferrante; Fiscal Year: 2004
    ..The use of DNA microarray technology will provide us with compelling information on the profile of cellular gene expression in immune cells of AIDS patients with fast and slow progressing PML, as well as those exhibiting NDLE. ..
  39. Effects of ART on Oral Epithelial Cell Biology
    Craig Miller; Fiscal Year: 2008
    ..These processes are key to maintaining oral mucosal health in patients who are infected with HIV and for understanding how opportunistic infections develop despite the presence of ART. [unreadable] [unreadable] [unreadable]..
  40. Cancer and Non-cancer Mortality in Meat Workers (1 RO1-OH 008687-01 A1 SOH)
    Eric Johnson; Fiscal Year: 2008
    ..Infectious disease is a NIOSH priority area. [unreadable] [unreadable] [unreadable]..
  41. Acquisition and Natural History of Genital HPV Infection
    Laura Koutsky; Fiscal Year: 2009
    ..In summary, the long-range goal of this project is to improve the effectiveness of both vaccine-based and behavioral strategies for preventing HPV infection. ..
  42. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
    ..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
  43. BK Virus as a Co-Factor in Prostate Cancer
    Michael Imperiale; Fiscal Year: 2009
    ..If a role for BKV in prostate cancer exists, there is the possibility of developing therapeutics or vaccines that are specific for the virus, thereby reducing the morbidity, mortality, and even the incidence of this cancer. ..
  44. Gene Therapy for Islet Cell Transplantation
    Manikkam Suthanthiran; Fiscal Year: 2002
    ..g., perforin) and proinflammatory cytokines (e.g., interferon-gamma) while stimulating the expression of mRNA encoding anti-inflammatory cytokines (e.g., interleukin-4). ..
  45. CYCLOSPORINE, TGF BETA1, AND IMMUNOSUPPRESSION
    Manikkam Suthanthiran; Fiscal Year: 2002
    ....
  46. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter C Doherty; Fiscal Year: 2010
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
  47. HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
    Janet Daling; Fiscal Year: 2004
    ..of CHRT associated with alteration in the histologic characteristics, tumor cell proliferation, or expression of steroid hormone receptors, oncogenes, and cell cycle and cell death regulator proteins of lobular and ductal breast cancers? ..
  48. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
    ....
  50. Genetics of Susceptibility to MMTV-Induced Mammary Tumor
    Susan Ross; Fiscal Year: 2006
    ..The results obtained from these studies will greatly increase our understanding of the genetic mechanisms which viruses use to infect their hosts and how genetic resistance to such viruses in the hosts occurs. ..
  51. Adherence Interventions for Drug Users
    Ann Williams; Fiscal Year: 2005
    ..Participants will be a multidisciplinary group of researchers and clinicians who are actively engaged in the study of adherence interventions among drug users and other vulnerable populations. ..
  52. Insulin and IGF In female colon, breast, uterine cancer
    Howard Strickler; Fiscal Year: 2005
    ....
  53. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2007
    ..abstract_text> ..
  54. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  55. Body size, physical activity, and Hodgkin's disease risk
    Sally Glaser; Fiscal Year: 2004
    ..abstract_text> ..
  56. Role of LIBC in Inflammatory Breast Cancer Phenotype
    Celina Kleer; Fiscal Year: 2007
    ..Also, understanding the role of WISP3 will shed light on the mechanisms of cancer development in general and serve as a model for other related CCN genes involved in carcinogenesis. ..
  57. Role of RNase L in the Biology of Prostate Cancer
    Robert Silverman; Fiscal Year: 2008
    ..The experiments described in this PROPOSAL describe a previously unexplored area of research that may bring us closer to the eventual goal of understanding a molecular basis for prostate cancer. ..
  58. THE ENDOTHELIAL CELL IN PATHOGENESIS OF TTP
    Jeffrey Laurence; Fiscal Year: 2004
    ..The model presented could also enable exploration of new therapeutic modalities for TTP, based upon modulation of specific apoptotic pathways. ..
  59. Identifying small molecule inhibitors of KSHV vFLIP-TRAF2 interactions.
    Ethel Cesarman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. HSP60 ABNORMALITIES IN SCHIZOPHRENIA
    Saud Sadiq; Fiscal Year: 2001
    ..Molecular studies will involve genomic and cDNA cloning of hsp60 from peripheral and brain tissue. Epitope mapping will be done by ELISA using overlapping peptides spanning the entire normal human hsp60 sequence. ..
  61. HPV Outcomes: Prevention Epidemiology and Surveillance (HOPES)
    Cosette Marie Wheeler; Fiscal Year: 2010
    ..Image-based diagnostic standards will be critical to future population evaluations. ..
  62. DNA Methylation as a Risk Factor for Cervical Neoplasia
    Long Fu Xi; Fiscal Year: 2009
    ..Data from the proposed study will not only shed light on our understanding of the role of CpG methylation in development of cervical neoplasia but also help to better design future cervical cancer control programs. ..
  63. Pathobiology of SAIDS-Associated Lymphomas
    Laura Levy; Fiscal Year: 2006
    ..A clear understanding of the mechanisms by which these cytokines effect positive and negative growth regulation of 1) lymphoma cells could contribute to the development of therapeutic agents that modulate their action. ..
  64. EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIA
    Long Fu Xi; Fiscal Year: 2003
    ..The proposed study is likely to make important contributions to our understanding of the role of HPV 16 and 18 variants in the pathogenesis of cervical cancer. ..
  65. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  66. CENTER FOR CANCER SIGNALING NETWORKS
    Walter Atwood; Fiscal Year: 2009
    ..This award will fund the retention of a young assistant professor, enable the hiring of a research assistant and provide a reasonable budget for supplies. ..
  67. 2nd Symposium on Polyomaviruses and Human Disease
    Walter Atwood; Fiscal Year: 2007
    ..The attendance is estimated at 80 people based on the success of the 1st International Symposium held last year in Italy. ..