acquired immunodeficiency syndrome

Summary

Summary: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.

Top Publications

  1. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
  2. ncbi The neuropathogenesis of AIDS
    Francisco González-Scarano
    Department of Neurology, 3 West Gates, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Philadelphia 19104 4283, USA
    Nat Rev Immunol 5:69-81. 2005
  3. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
  4. pmc Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review
    Sydney Rosen
    Center for International Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e298. 2007
  5. pmc Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype
    A Bjorndal
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Virol 71:7478-87. 1997
  6. ncbi Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    Maria J Wawer
    Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
    J Infect Dis 191:1403-9. 2005
  7. ncbi Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City
    Judith E Sackoff
    HIV Epidemiology Program, Bureau of HIV AIDS Prevention and Control, New York City Department of Health and Mental Hygiene, New York, New York 10013, USA
    Ann Intern Med 145:397-406. 2006
  8. ncbi The survival benefits of AIDS treatment in the United States
    Rochelle P Walensky
    Division of Infectious Disease and General Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Infect Dis 194:11-9. 2006
  9. doi "Know your epidemic, know your response": a useful approach, if we get it right
    David Wilson
    World Bank, Washington, DC, USA
    Lancet 372:423-6. 2008
  10. ncbi Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    Mette D Hazenberg
    Department of Clinical Viro Immunology, Sanquin Research at CLB, Tropical Medicine and AIDS, Amsterdam, The Netherlands
    AIDS 17:1881-8. 2003

Detail Information

Publications373 found, 100 shown here

  1. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  2. ncbi The neuropathogenesis of AIDS
    Francisco González-Scarano
    Department of Neurology, 3 West Gates, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Philadelphia 19104 4283, USA
    Nat Rev Immunol 5:69-81. 2005
    ..Here, we discuss the studies that are being carried out to determine the respective contributions of infection, and monocyte and macrophage activation, to disease progression...
  3. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
    ..present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS)...
  4. pmc Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review
    Sydney Rosen
    Center for International Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e298. 2007
    ..In this paper we present a systematic review of patient retention in ART programs in sub-Saharan Africa...
  5. pmc Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype
    A Bjorndal
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Virol 71:7478-87. 1997
    ..The results show that all 36 primary HIV-1 isolates induce syncytia, provided that target cells carry the particular coreceptor required by the virus...
  6. ncbi Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    Maria J Wawer
    Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
    J Infect Dis 191:1403-9. 2005
    ..We estimated rates of human immunodeficiency virus (HIV)-1 transmission per coital act in HIV-discordant couples by stage of infection in the index partner...
  7. ncbi Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City
    Judith E Sackoff
    HIV Epidemiology Program, Bureau of HIV AIDS Prevention and Control, New York City Department of Health and Mental Hygiene, New York, New York 10013, USA
    Ann Intern Med 145:397-406. 2006
    ..Monitoring the full spectrum of causes of death among persons with AIDS is increasingly important as survival improves because of highly active antiretroviral therapy...
  8. ncbi The survival benefits of AIDS treatment in the United States
    Rochelle P Walensky
    Division of Infectious Disease and General Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Infect Dis 194:11-9. 2006
    As widespread adoption of potent combination antiretroviral therapy (ART) reaches its tenth year, our objective was to quantify the cumulative survival benefits of acquired immunodeficiency syndrome (AIDS) care in the United States.
  9. doi "Know your epidemic, know your response": a useful approach, if we get it right
    David Wilson
    World Bank, Washington, DC, USA
    Lancet 372:423-6. 2008
  10. ncbi Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    Mette D Hazenberg
    Department of Clinical Viro Immunology, Sanquin Research at CLB, Tropical Medicine and AIDS, Amsterdam, The Netherlands
    AIDS 17:1881-8. 2003
    ..HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood...
  11. ncbi Responding to the HIV pandemic: the power of an academic medical partnership
    Robert M Einterz
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Acad Med 82:812-8. 2007
    ....
  12. ncbi Determinants of survival following HIV-1 seroconversion after the introduction of HAART
    Kholoud Porter
    Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Lancet 362:1267-74. 2003
    ..Highly active antiretroviral therapy (HAART) was introduced in 1997. We aimed to assess the continuing effect of this treatment on survival and progression to AIDS after HIV-1 seroconversion...
  13. pmc HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
    Rasmi Thomas
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1290-4. 2009
    ....
  14. ncbi Trends in cancer risk among people with AIDS in the United States 1980-2002
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    AIDS 20:1645-54. 2006
    ..People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality, but there are few large-scale studies on cancer trends...
  15. pmc Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS
    Robert J Biggar
    Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm EPS 7074, Bethesda, MD 20852, USA
    Blood 108:3786-91. 2006
    ..With more severe immunosuppression, nodular sclerosing HL becomes infrequent, explaining the higher proportion of mixed cellularity HL found in PWAs. Pathogenesis implications are discussed...
  16. pmc Rapid evolution of the neutralizing antibody response to HIV type 1 infection
    Douglas D Richman
    Department of Pathology, Veterans Affairs San Diego Healthcare System and the University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 100:4144-9. 2003
    ..These data argue that neutralizing antibody responses account for the extensive variation in the envelope gene that is observed in the early months after primary HIV infection...
  17. ncbi Meta-analysis of the relationship between HIV infection and risk for depressive disorders
    J A Ciesla
    Department of Psychology, State University of New York at Buffalo, 14260-4110, USA
    Am J Psychiatry 158:725-30. 2001
    ..Future research should focus on identifying pathways of risk and resilience for depression within this population...
  18. pmc Host genes associated with HIV/AIDS: advances in gene discovery
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Trends Genet 26:119-31. 2010
    ..Multidisciplinary approaches integrating genetic epidemiology to systems biology will be required to fully understand virus-host interactions to effectively combat HIV/AIDS...
  19. pmc Steep declines in population-level AIDS mortality following the introduction of antiretroviral therapy in Addis Ababa, Ethiopia
    Georges Reniers
    Population Program, Institute of Behavioral Science, University of Colorado, Boulder, Colorado, USA
    AIDS 23:511-8. 2009
    ..We use data from burial sites to estimate trends in adult AIDS mortality and the mitigating effects of ART in Addis Ababa. ART has been available since 2003, and for free since 2005...
  20. pmc Risk of human papillomavirus-associated cancers among persons with AIDS
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Natl Cancer Inst 101:1120-30. 2009
    ....
  21. ncbi The social epidemiology of human immunodeficiency virus/acquired immunodeficiency syndrome
    K E Poundstone
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Epidemiol Rev 26:22-35. 2004
  22. pmc Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS
    Joshua T Herbeck
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    J Infect Dis 201:618-26. 2010
    ..To investigate host genetic determinants of the rate of progression to clinical AIDS, we performed a multistage genomewide association study...
  23. pmc Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in Uganda
    Noeline Nakasujja
    Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    BMC Psychiatry 10:44. 2010
    ..Initiation of highly active antiretroviral therapy (HAART) may have an effect on the prevalence and the change over time of depression symptoms and cognitive impairment among HIV-positive individuals...
  24. pmc Understanding and addressing AIDS-related stigma: from anthropological theory to clinical practice in Haiti
    Arachu Castro
    Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, 641 Huntington Ave, Boston, MA 02115, USA
    Am J Public Health 95:53-9. 2005
    ..Rather than stigma, logistic and economic barriers determine who will access such services. Implications for scale-up of integrated AIDS prevention and care are explored...
  25. pmc Public health. Reassessing HIV prevention
    Malcolm Potts
    School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Science 320:749-50. 2008
  26. pmc Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
    J Exp Med 200:701-12. 2004
    ..This identification of a reversible defect in cell-mediated immunity in chronic HIV-1 infection has important implications for immunotherapeutic interventions...
  27. pmc Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies
    Ming Li
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Virol 79:10108-25. 2005
    ..These reference reagents will facilitate proficiency testing and other validation efforts aimed at improving assay performance across laboratories and can be used for standardized assessments of vaccine-elicited neutralizing antibodies...
  28. doi Immune activation and AIDS pathogenesis
    Donald L Sodora
    AIDS 22:439-46. 2008
  29. ncbi Levels and causes of adult mortality in rural South Africa: the impact of AIDS
    Victoria Hosegood
    Africa Centre for Health and Population Studies, Mtubatuba, South Africa
    AIDS 18:663-71. 2004
    ..To quantify the contribution that AIDS makes to adult mortality in rural South Africa...
  30. pmc HIV-related stigma and knowledge in the United States: prevalence and trends, 1991-1999
    Gregory M Herek
    Department of Psychology, University of California at Davis, 1 Shields Avenue, Davis, CA 95616 8686, USA
    Am J Public Health 92:371-7. 2002
    ..This study assessed the prevalence of AIDS stigma and misinformation about HIV transmission in 1997 and 1999 and examined trends in stigma in the United States during the 1990s...
  31. pmc Cumulative incidence of cancer among individuals with acquired immunodeficiency syndrome in the United States
    Edgar P Simard
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer 117:1089-96. 2011
    The overall burden of cancer may increase as individuals with acquired immunodeficiency syndrome (AIDS) live longer because of highly active antiretroviral therapy (HAART), which has been widely available since 1996.
  32. ncbi Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
    D R Burton
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 266:1024-7. 1994
    ..The broad specificity and efficacy of the antibody implies the conservation of a structural feature on gp120, which could be important in vaccine design...
  33. ncbi Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy
    Samuel A Shelburne
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Medicine (Baltimore) 81:213-27. 2002
  34. ncbi Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    Punnee Pitisuttithum
    Department of Clinical Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Infect Dis 194:1661-71. 2006
    ....
  35. ncbi Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: a combined study of two cohorts
    Lucette A Cysique
    Faculty of Medicine, St Vincent s Clinical School, University of New South Wales, Sydney, Australia
    J Neurovirol 10:350-7. 2004
    ..deficits in nondemented advanced HIV-infected individuals, patients with a current diagnosis of acquired immunodeficiency syndrome (AIDS) dementia complex were not included...
  36. ncbi Changing mortality rates and causes of death for HIV-infected individuals living in Southern Alberta, Canada from 1984 to 2003
    H B Krentz
    Southern Alberta Clinic, Calgary, Alberta, Canada
    HIV Med 6:99-106. 2005
    ..To examine changes over a 2-year period in both the mortality rate and the causes of death in a geographically defined HIV-infected population...
  37. ncbi Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome
    Elizabeth M Kang
    Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 99:698-701. 2002
    ..These results suggest that nonmyeloablative allogeneic transplantation in the context of highly active antiretroviral therapy is feasible in patients with treatment-sensitive HIV infection...
  38. ncbi HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China
    Bo Su
    Modern Virology Research Center, College of Life Sciences, Wuhan University, Hubei 430072, PR China
    AIDS 17:2515-20. 2003
    ..To investigate the genetic background of HIV-1 strains among infected paid blood donors (PBD) in the Henan and Hubei provinces of China...
  39. pmc Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, Uganda
    Andrew M Abaasa
    Clinical Epidemiology Unit, Makerere University, Kampala, Uganda
    BMC Health Serv Res 8:241. 2008
    ..We therefore conducted a study to assess the effect of adherence to HAART on survival in The AIDS Support Organization (TASO) community HAART programme in Kampala, Uganda...
  40. ncbi Initial plasma HIV-1 RNA levels and progression to AIDS in women and men
    T R Sterling
    Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD, USA
    N Engl J Med 344:720-5. 2001
    ..In men, the initial viral load after seroconversion predicts the likelihood of progression to the acquired immunodeficiency syndrome (AIDS), but the relation between the two has not been assessed in women...
  41. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
    ....
  42. pmc How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?
    Per Johan Klasse
    Department of Microbiology and Immunology, Cornell University, Weill Cornell Medical College, New York, New York 10065 4896, USA
    AIDS Res Hum Retroviruses 28:1-15. 2012
    ..Drawing on these analyses, we outline strategies for improving Env as a component of a vaccine aimed at inducing strong and sustained NAb responses...
  43. pmc CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection
    Jason V Baker
    University of Minnesota, Minneapolis, USA
    AIDS 22:841-8. 2008
    ..Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases in chronic non-AIDS end-organ diseases among HIV+ patients...
  44. ncbi Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies
    Joanne Reekie
    University College London Medical School, London, UK
    Cancer 116:5306-15. 2010
    In the combined antiretroviral therapy (cART) era, non-acquired immunodeficiency syndrome (AIDS)-defining malignancies account for more morbidity and mortality in human immunodeficiency virus-infected patients than AIDS-defining ..
  45. ncbi Antiretroviral therapy and sexual behavior: a comparative study between antiretroviral- naive and -experienced patients at an urban HIV/AIDS care and research center in Kampala, Uganda
    Moses Bateganya
    Makerere University Institute of Public Health Centers for Disease Control and Prevention IPHCDC HIV AIDS Fellowship Program, Kampala, Uganda
    AIDS Patient Care STDS 19:760-8. 2005
    ..Still, recall and social desirability biases remain important limitations in interpreting these conclusions...
  46. ncbi Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Ann Intern Med 135:782-95. 2001
    ..Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results...
  47. ncbi Health systems strengthening through insurance subsidies: the GFATM experience in Rwanda
    Andreas Kalk
    GTZ Health, Eschborn, Germany
    Trop Med Int Health 15:94-7. 2010
    ..This success was achieved with limited financial resources. In consequence, interventions that strengthen health systems should always be considered for a prominent--if not a priority role--in GFATM-funded projects...
  48. pmc Gender and AIDS: time to act
    Alan Greig
    Institute for Development Studies, University of Sussex, Brighton, UK
    AIDS 22:S35-43. 2008
    ..This paper argues that we can no longer simply pay lip service to the urgent need to act on what we know about gender and AIDS. Simply put, it is time to act...
  49. pmc Peptides in the treatment of AIDS
    Fred Naider
    Department of Chemistry, College of Staten Island of the City University of New York, Staten Island, New York 10314, USA
    Curr Opin Struct Biol 19:473-82. 2009
    ..Knowledge of the structural biology of gp41 allows the design of potent peptide inhibitors that prevent the virus from entering lymphocytes and macrophages. The design of such inhibitors is the subject of this review...
  50. pmc Is the US AIDS drug assistance program cost-effective?
    Steven D Pinkerton
    Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 2071 North Summit Avenue, Milwaukee, WI 53202, USA
    AIDS Behav 17:1-4. 2013
    ..The net cost per quality-adjusted life year saved was $11,955, which suggests that the ADAP program is cost-effective by conventional standards...
  51. pmc Sepsis is a major determinant of outcome in critically ill HIV/AIDS patients
    Andre M Japiassu
    Intensive Care Unit, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Rio de Janeiro, Brazil
    Crit Care 14:R152. 2010
    ..We prospectively followed up critically ill HIV/AIDS patients to evaluate the main risk factors for hospital mortality and the impact of severe sepsis on the short- and long-term survival...
  52. ncbi Hyponatremia in hospitalized patients with the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex
    W W Tang
    Division of Nephrology, University of Southern California, Los Angeles
    Am J Med 94:169-74. 1993
    ..To determine the frequency, etiology, and clinical association of hyponatremia in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC)...
  53. ncbi Scaling-up antiretroviral treatment in Southern African countries with human resource shortage: how will health systems adapt?
    Wim Van Damme
    Institute of Tropical Medicine, Department of Public Health, Nationalestraat 155, 2000 Antwerp, Belgium
    Soc Sci Med 66:2108-21. 2008
    ..The latter two scenarios would entail a high degree of de-medicalisation of ART...
  54. pmc Perceived discrimination and stigma toward children affected by HIV/AIDS and their HIV-positive caregivers in central Haiti
    Pamela J Surkan
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    AIDS Care 22:803-15. 2010
    ....
  55. ncbi The enhancement of RNAi against HIV in vitro and in vivo using H-2K(k) protein as a sorting method
    Ying Gu
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    J Virol Methods 182:9-17. 2012
    ..These studies offer a practical method to accumulate virally transduced cells, which can be applied to evaluate the performance of various shRNAs constructs...
  56. pmc How much can we gain from improved efficiency? An examination of performance of national HIV/AIDS programs and its determinants in low- and middle-income countries
    Wu Zeng
    Schneider Institutes for Health Policy, Heller School, MS 035, Brandeis University, Waltham, MA 02454 9110, USA
    BMC Health Serv Res 12:74. 2012
    ..The economic downturn exacerbates the inadequacy of resources for combating the worldwide HIV/AIDS pandemic and amplifies the need to improve the efficiency of HIV/AIDS programs...
  57. ncbi All-cause and liver-related mortality in HIV positive subjects compared to the general population: differences by HCV co-infection
    Victoria Hernando
    Red de Investigación en SIDA, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Madrid, Spain
    J Hepatol 57:743-51. 2012
    ....
  58. pmc Community-based treatment of advanced HIV disease: introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy)
    P Farmer
    Department of Social Medicine, Harvard Medical School, Boston, MA, USA
    Bull World Health Organ 79:1145-51. 2001
    In 2000, acquired immunodeficiency syndrome (AIDS) overtook tuberculosis (TB) as the world's leading infectious cause of adult deaths...
  59. pmc HIV surveillance in MENA: recent developments and results
    Ivana Bozicevic
    World Health Organization Collaborating Centre for HIV Surveillance, University of Zagreb School of Medicine, Zagreb, Croatia
    Sex Transm Infect 89:iii11-16. 2013
    ....
  60. ncbi Social, behavioural, and intervention research among people of Sub-Saharan African origin living with HIV in the UK and Europe: literature review and recommendations for intervention
    Audrey Prost
    MRC Social and Public Health Sciences, Unit 4 Lilybank Gardens, Glasgow, G12 8RZ, UK
    AIDS Behav 12:170-94. 2008
    ....
  61. pmc A randomized controlled trial of a peer support intervention targeting antiretroviral medication adherence and depressive symptomatology in HIV-positive men and women
    Jane M Simoni
    Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Health Psychol 26:488-95. 2007
    ..To determine the efficacy of a peer-led social support intervention involving support groups and telephone contacts compared with standard clinical care to enhance antiretroviral medication adherence...
  62. ncbi Mitochondrial membrane potential and apoptosis of blood mononuclear cells in untreated HIV-1 infected patients
    Thomas Sternfeld
    II Medizinische Klinik und Poliklinik, Infektionsambulanz, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    HIV Med 10:512-9. 2009
    ..Mitochondrial dysfunction is a pivotal step of the apoptotic cascade and can result in reduced mitochondrial membrane potential...
  63. pmc Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    Saurabh Mehandru
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Fl, New York, NY 10016, USA
    J Exp Med 200:761-70. 2004
    ..Given the importance of the mucosal compartment in HIV-1 pathogenesis, further study to elucidate the significance of the changes observed here is critical...
  64. pmc A cross-sectional description of social capital in an international sample of persons living with HIV/AIDS (PLWH)
    Allison Webel
    Frances Payne Bolton School of Nursing Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4904, USA
    BMC Public Health 12:188. 2012
    ..The purpose of our paper was to describe the degree of social capital in an international sample of adults living with HIV/AIDS...
  65. pmc Identifying the impact of social determinants of health on disease rates using correlation analysis of area-based summary information
    Ruiguang Song
    Center for Disease Control and Prevention, National Center for HIV AIDS, Viral Herpatitis, STD, and TB Prevention, Division of HIV AIDS Prevention, Atlanta, GA 30333, USA
    Public Health Rep 126:70-80. 2011
    ....
  66. ncbi Predicting HIV in a public dental facility using group I oral lesions
    A Bhayat
    Division of Public Oral Health, Schools of Public Health and Oral Health Sciences, University of the Witwatersrand
    SADJ 63:538, 540, 542-3. 2008
    ..No study has evaluated the predictability of these lesions in diagnosing HIV/AIDS in patients who attend dental public facilities in South Africa...
  67. ncbi Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)
    Sigrid Le Clerc
    Conservatoire National des Arts et Metiers, Paris, France
    J Infect Dis 200:1194-201. 2009
    ..The discovery of genetic factors that predispose individuals to rapid progression to AIDS should also reveal new insights into the molecular etiology of the pathology...
  68. pmc Uganda's HIV prevention success: the role of sexual behavior change and the national response
    Edward C Green
    Harvard University School of Public Health, Boston, Massachusetts, USA
    AIDS Behav 10:335-46; discussion 347-50. 2006
    ..Yet the debate over "what happened in Uganda" continues, often involving divisive abstinence-versus-condoms rhetoric, which appears more related to the culture wars in the USA than to African social reality...
  69. pmc Examination of inequalities in HIV/AIDS mortality in the United States from a fundamental cause perspective
    Marcie S Rubin
    Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York City, NY, USA
    Am J Public Health 100:1053-9. 2010
    ..We examined changes in socioeconomic status (SES) and Black to White inequalities in HIV/AIDS mortality in the United States before and after the introduction of highly active antiretroviral therapy (HAART)...
  70. ncbi Relation between chemokine receptor use, disease stage, and HIV-1 subtypes A and D: results from a rural Ugandan cohort
    Pontiano Kaleebu
    Medical Research Council Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda
    J Acquir Immune Defic Syndr 45:28-33. 2007
    ..To determine whether there are differences in coreceptor use in subjects infected with HIV-1 envelope subtypes A and D that could explain the differences in progression rates between these subtypes in a rural Ugandan cohort...
  71. ncbi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  72. ncbi Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard Room 4277, MSC 9555, Bethesda, MD 20892 9555, USA
    Mol Neurobiol 44:102-10. 2011
    ..Increased cell death of dopaminergic neurons can eventually lead to dopamine deficit that may exacerbate the severity and/or accelerate the progression of HAND/HAD...
  73. pmc Explaining adherence success in sub-Saharan Africa: an ethnographic study
    Norma C Ware
    Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 6:e11. 2009
    ..This paper offers an explanation and theoretical model of ART adherence success based on the results of an ethnographic study in three sub-Saharan African countries...
  74. ncbi Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia
    Jorge Cortes
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 94:1492-9. 2002
    Patients with acquired immunodeficiency syndrome (AIDS)-associated lymphoma/leukemia have a poor prognosis and are frequently treated with low-intensity therapy...
  75. pmc Effect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomized trial
    Larry W Chang
    Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 5:e10923. 2010
    ..We conducted a cluster randomized trial to assess the effect of community-based peer health workers (PHW) on AIDS care of adults in Rakai, Uganda...
  76. pmc Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
    N R Klatt
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    Mucosal Immunol 3:387-98. 2010
    ..Furthermore, these data suggest that PTM may be an ideal model to study therapeutic interventions aimed at decreasing microbial translocation-induced immune activation...
  77. pmc Genome-wide association study implicates PARD3B-based AIDS restriction
    Jennifer L Troyer
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
    J Infect Dis 203:1491-502. 2011
    ..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression...
  78. pmc Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions
    Elvin H Geng
    Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA
    Curr HIV/AIDS Rep 7:234-44. 2010
    ..Research to assess and improve retention in care for HIV-infected patients can be strengthened by incorporating novel methods such as sampling-based approaches and a causal analytic framework...
  79. pmc Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the multicenter AIDS cohort study
    James C Shepherd
    School of Medicine, Johns Hopkins University, MD, USA
    J Infect Dis 198:1104-12. 2008
    ..We conclude that HIV-1 variants that used X4 frequently emerged at high CD4(+) T cell counts and may contribute to the decrease in T cell numbers during late HIV-1 infection...
  80. ncbi Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy
    Viviane D Lima
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    AIDS 21:685-92. 2007
    ..To characterize the temporal changes in mortality and life expectancy among HIV-positive individuals initiating antiretroviral therapy in British Columbia, Canada, from 1993 to 2004...
  81. pmc Quality of life outcomes of antiretroviral treatment for HIV/AIDS patients in Vietnam
    Bach Xuan Tran
    School of Public Health, University of Alberta, Edmonton, Canada
    PLoS ONE 7:e41062. 2012
    ..This study assessed health-related quality of life (HRQOL) and its related factors in HIV/AIDS patients taking antiretroviral treatment (ART) in Vietnam...
  82. ncbi Predictors of HIV-preventive sexual behavior in a high-risk adolescent population: the influence of perceived peer norms and sexual communication on incarcerated adolescents' consistent use of condoms
    R J Diclemente
    Center for AIDS Prevention Studies, University of California, San Francisco 94105
    J Adolesc Health 12:385-90. 1991
    ....
  83. ncbi The health-related quality of life of people living with HIV/AIDS
    Janeen Hughes
    Department of Health and Rehabilitation Sciences, University of Cape Town, South Africa
    Disabil Rehabil 26:371-6. 2004
    ..However, there is limited information available to determine the potential role of rehabilitation interventions in the management of PLWA in a resource-poor community...
  84. ncbi The changing clinical epidemiology of AIDS in the highly active antiretroviral therapy era
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 16:S61-8. 2002
  85. ncbi China's floating population and the potential for HIV transmission: a social-behavioural perspective
    A F Anderson
    School of Public and Environmental Affairs, Indiana University Kokomo, Kokomo, Indiana 46904 9003, USA
    AIDS Care 15:177-85. 2003
    ..Given the sheer size and broad movement of this population, it is contended that it may well be a 'tipping point' factor in AIDS prevention and control in China...
  86. pmc Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    M M Addo
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School Fenway Community Health Center Lemuel Shattuck Hospital, Boston, Massachusetts 02129, USA
    J Virol 77:2081-92. 2003
    ....
  87. pmc Loneliness and HIV-related stigma explain depression among older HIV-positive adults
    Christian Grov
    Department of Health and Nutrition Sciences, Brooklyn College of City University of New York, NY, USA
    AIDS Care 22:630-9. 2010
    ..Data suggest that focusing efforts to reduce HIV-related stigma and loneliness may have lasting effects in reducing major depressive symptoms and improving perceived health...
  88. ncbi Disclosure of HIV status: experiences and perceptions of persons living with HIV/AIDS and nurses involved in their care in Africa
    Minrie Greeff
    School of Nursing Science, North West University, Potchefstroom Campus, Potchefstroom, South Africa
    Qual Health Res 18:311-24. 2008
    ..Most health literature seems to favor disclosure by persons living with acquired immunodeficiency syndrome (AIDS), but it could be that to disclose is not always a good thing...
  89. pmc Exposing misclassified HIV/AIDS deaths in South Africa
    Jeanette Kurian Birnbaum
    Institute for Health Metrics and Evaluation, University of Washington, 2301 5th Avenue Suite 600, Seattle, WA 98121, United States of America
    Bull World Health Organ 89:278-85. 2011
    To quantify the deaths from human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) that are misattributed to other causes in South Africa's death registration data and to adjust for this bias.
  90. ncbi Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome
    Kent A Sepkowitz
    Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA
    Clin Infect Dis 34:1098-107. 2002
    ..other than that caused by HIV infection, may be different than those encountered in patients with acquired immunodeficiency syndrome. Reviewed are 4 common opportunistic infections: Pneumocystis carinii pneumonia, cryptococcosis, ..
  91. ncbi "All I eat is ARVs": the paradox of AIDS treatment interventions in central Mozambique
    Ippolytos Andreas Kalofonos
    Department of Psychiatry University of Washington, USA
    Med Anthropol Q 24:363-80. 2010
    ..Discourses of hunger serve as a critique of these shortcomings, and of the wider political economy underlying the HIV/AIDS epidemic...
  92. pmc Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 2:E275. 2004
    ..Despite being only recently discovered, editing of RNA and DNA may thus represent an ancient form of host defense in primate genomes...
  93. ncbi The economic burden of illness for households in developing countries: a review of studies focusing on malaria, tuberculosis, and human immunodeficiency virus/acquired immunodeficiency syndrome
    Steven Russell
    School of Development Studies, University of East Anglia, Norwich, United Kingdom
    Am J Trop Med Hyg 71:147-55. 2004
    ..a process brought into sharper focus by the impact of the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic...
  94. ncbi Ties of dependence: AIDS and transactional sex in rural Malawi
    Ann Swidler
    Department of Sociology, University of California, Berkeley, CA 94720 1980, USA
    Stud Fam Plann 38:147-62. 2007
    ..We argue that the exchange of sex for money is better understood as one of the many ties of unequal exchange in which Malawians and other Africans engage, an exchange in which the patrons are as important as the clients...
  95. pmc Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management
    Jane M Simoni
    Department of Psychology, University of Washington, Seattle, Washington, 98195 1525, Box 351525, USA
    AIDS Behav 10:227-45. 2006
    ..We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management...
  96. ncbi Abnormal striatal dopaminergic synapses in National NeuroAIDS Tissue Consortium subjects with HIV encephalitis
    Benjamin B Gelman
    Department of Pathology, Route 0785, University of Texas Medical Branch, Galveston, Texas 77555 0785, USA
    J Neuroimmune Pharmacol 1:410-20. 2006
    ..Increased DAergic tone leads to heightened salience for drugs of abuse, increases behaviors that increase the risk of HIV transmission, and might decrease compliance with antiretroviral medication regimens...
  97. pmc Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Virol 82:11536-44. 2008
    ..These data demonstrate an important signaling event of Nef in HIV-1 pathogenesis...
  98. ncbi Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis
    Andrew E Grulich
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Lancet 370:59-67. 2007
    ..Our aim was to compare cancer incidence in population-based cohort studies of people with HIV/AIDS and people immunosuppressed after solid organ transplantation...
  99. pmc Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
    Xiao Feng Qin
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Proc Natl Acad Sci U S A 100:183-8. 2003
    ..Thus, our studies demonstrate the feasibility and potential of lentiviral vector-mediated delivery of siRNAs as a general means of intracellular immunization for the treatment of HIV-1 and other viral diseases...
  100. pmc Validity/reliability of PHQ-9 and PHQ-2 depression scales among adults living with HIV/AIDS in western Kenya
    Patrick O Monahan
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 3002, USA
    J Gen Intern Med 24:189-97. 2009
    ..Patient Health Questionnaire-9 (PHQ-9), a brief dual-purpose instrument yielding DSM-IV diagnoses and severity, and PHQ-2, an ultra-brief screening tool, offer advantages in resource-constrained settings...
  101. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
    ..These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses...

Research Grants73

  1. White matter changes in HIV models
    Pamela E Knapp; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Acquired immunodeficiency syndrome, caused by human immunodeficiency virus-1 (HIV-1) infection, is the most common cause of dementia in non-aged individuals in the US...
  2. Crystalline Endolysin Treatment for Tuberculosis in TB/HIV co-infected patients
    BHAMI C SHENOY; Fiscal Year: 2012
    ..most common cause of death from infectious disease in the world after human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)...
  3. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..In addition, the results will fundamentally advance the field of cardio-pulmonary vascular research in general. ..
  4. Agnoprotein in JC virus virion biogenesis and replication
    Mahmut Safak; Fiscal Year: 2012
    ..patients with underlying disorders such as lymphoproliferative and myeloproliferative diseases and acquired immunodeficiency syndrome, (AIDS)...
  5. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    ..Rim101 pathway), 2) Determine if PS and PE play a role in evading the immune response 3) Discover if auxotrophy for ethanolamine, a known substrate of PE, affects virulence of the mutants in the host. ..
  6. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
    Christina L Nance; Fiscal Year: 2011
    More than 30 million adults and children worldwide have died from acquired immunodeficiency syndrome (AIDS) and 40 million are living with the human immunodeficiency virus (HIV)...
  7. Molecular epidemiology of non-Hodgkin lymphoma prognosis and prevention
    Sophia Wang; Fiscal Year: 2013
    ..g., viral infections, acquired immunodeficiency syndrome)...
  8. Release and trafficking of JC polyomavirus genomes and implications in AIDS
    CHRISTIAN DOUGLAS STUART NELSON; Fiscal Year: 2012
    ..multifocal leukoencephalopathy (PML) in immunocompromised individuals, especially patients with Acquired Immunodeficiency Syndrome (AIDS)...
  9. Benzophenones: Novel natural agents which inhibits HIV and Candida
    Ramiro Mendonca Murata; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Acquired immunodeficiency syndrome (AIDS) is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies...
  10. Benzophenones: Novel natural agents which inhibits HIV and Candida
    Ramiro Mendonca Murata; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acquired immunodeficiency syndrome (AIDS) is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies...
  11. Mode of action of a new Tat HIV-1 inhibitor
    Susana T Valente; Fiscal Year: 2013
    ..Human immunodeficiency virus type I (HIV-1) is the causative agent of AIDS (Acquired Immunodeficiency Syndrome)...
  12. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency syndrome (AIDS). AIDS is characterized by CD4+ T lymphocyte depletion...
  13. Macaque model of TB/AIDS co-infection via natural routes of exposure
    Deepak Kaushal; Fiscal Year: 2010
    ..2. Determine if rhesus macaques latently infected with low-dose aerosols of Mtb reactivate to active disease in a significantly different fashion, following intravenous SIV infection. ..
  14. Effects of HIV- and ARV-Induced Oxidative Stress on Neuroglial Cells
    BRIGID JENSEN; Fiscal Year: 2013
    DESCRIPTION: 33 million individuals worldwide are infected with HIV. Acquired immunodeficiency syndrome is now staved off by antiretroviral (ARV) drugs which suppress viral replication and restore immune system function...
  15. Recruitment of host noncoding RNAs by XMRV
    Sandra L Wolin; Fiscal Year: 2012
    ..This proposal tests whether the tendency of XMRV and other retroviruses to capture RNA molecules from infected cells can be used to identify new targets for designing antiviral drugs. ..
  16. Genome Integrity in Candida albicans
    Judith G Berman; Fiscal Year: 2013
    ..Virus (HIV) and the most prevalent opportunistic infection observed in patients with Acquired Immunodeficiency Syndrome (AIDS). C...
  17. Alpha-galactosycleramide as a mucosal adjuvant for HIV antigens
    JAGANNADHA K SASTRY; Fiscal Year: 2010
    Vaccination for protection against sexually transmitted diseases such as acquired immunodeficiency syndrome (AIDS) caused by human immunodeficiency virus (HIV) infection should concentrate on inducing strong antigen-specific humoral and ..
  18. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2010
    ..However, synergistic effects have been observed in drug combination treatments for acquired immunodeficiency syndrome and cancers...
  19. A Lassa Vaccine in primates with AIDS
    Maria Salvato; Fiscal Year: 2009
    ..Lassa vaccine (MOP/LAS) will remain attenuated in macaques where immunity is suppressed during SIV-acquired immunodeficiency syndrome (AIDS)...
  20. Factors That Affect Endometrial Immunity: Implications for HIV Infection
    Joseph C Chen; Fiscal Year: 2012
    ..HIV-associated pathologies, including Acquired Immunodeficiency Syndrome (AIDS), continue to be a global pandemic as of 2011...
  21. Epigenetic factors and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
    ..provided by applicant): HIV-associated nephropathy (HIVAN) is an important complication of acquired immunodeficiency syndrome (AIDS)...
  22. Label-free HIV-1 Viral Load Measurement through a Contactless Electrode Microchip
    Hadi Shafiee; Fiscal Year: 2013
    ..This proposal will provide an inexpensive method for HIV-1 viral load measurements at POC that is compatible with mass fabrication technologies with a great promise to be commercialized. ..
  23. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2013
    ..However, synergistic effects have been observed in drug combination treatments for acquired immunodeficiency syndrome and cancers...
  24. Mucosal Immune Dysfunction after SIV Infection
    NICHOLE ROSE KLATT; Fiscal Year: 2013
    ..of the immune system, particularly in mucosal tissues, which ultimately results in progression to Acquired Immunodeficiency Syndrome and death...
  25. HIV-1 TAR derived miRNA: Implications for Latency and Pathogenesis
    Fatah Kashanchi; Fiscal Year: 2010
    ..provided by applicant): Human Immunodeficiency Virus type I (HIV-1) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS)...
  26. Actions of Vif and APOBEC3 proteins in HIV-1 Replication
    Yong Hui Zheng; Fiscal Year: 2010
    ..Such findings may provide a more effective modality for the treatment of HIV infection to be used in conjunction with other chemotherapy and vaccines. ..
  27. Murine AIDS (LP-BM5) viral infection induced peripheral neuropathy - Role of CNS
    Ling Cao; Fiscal Year: 2010
    ..Unfortunately, amongst the extensive current HIV/AIDS (acquired immunodeficiency syndrome) research, DSP is an understudied area with few animal models available...
  28. Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor Inhibition
    CRAIG WOODWORTH; Fiscal Year: 2009
    ..Since drugs that inhibit this receptor have already been approved to treat lung and colorectal cancer, it is reasonable to test whether they also inhibit cervical carcinogenesis. ..
  29. Pharmacogenomics of HIV Therapy
    David W Haas; Fiscal Year: 2012
    ABSTRACT Access to potent antiretroviral drugs markedly reduces acquired immunodeficiency syndrome (AIDS) morbidity and mortality...
  30. Rescuing the anti-HIV activity of APOBEC3G with small-molecule chaperons
    Sergey N Savinov; Fiscal Year: 2010
    ..HIV) is able to counteract this intrinsic protective system making the disease that it causes, Acquired Immunodeficiency Syndrome (AIDS), a global health problem, with no cure or prevention in sight...
  31. A Novel Ubiquitin-Dependent Pathogenic Pathway in Spongiform Neurodegeneration
    Lih Shen Chin; Fiscal Year: 2013
    ..The results of the proposed studies will provide fundamental information needed for the development of effective therapeutics to combat age-related neurodegenerative diseases. ..
  32. Flow-enhanced characterization of drug-resistant viruses
    John Yin; Fiscal Year: 2010
    Viruses pose a significant threat to human health based on their ability to cause diseases such as acquired immunodeficiency syndrome (AIDS), influenza, hepatitis, cancer, severe acute respiratory syndrome (SARS), hemorrhagic fever and ..
  33. An innovative mobile-based game, named Sexually Active Adolescent Focused Educati
    TONY XUYEN MA; Fiscal Year: 2012
    ....
  34. Design &Synthesis of Nonpeptide Protease Inhibitors
    Arun K Ghosh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acquired immunodeficiency syndrome (AIDS) is one of the most destructive epidemics in medical history...
  35. Retrospective cohort study of racial disparities in HIV survival, Florida
    Mary Jo Trepka; Fiscal Year: 2013
    ..This supports the National Center for Minority Health and Health Disparities mission to "reduce and ultimately eliminate health disparities." ..
  36. Role of nucleic acid structure in HIV-1 replication
    Chandravanu Dash; Fiscal Year: 2011
    b>Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HlV-1) is one of the most important challenges for chemotherapy of the early 21 st century...
  37. INHIBITION OF HIV 1 REPLICATION BY CYTOTOXIC LYMPHOCYTES
    Bruce D Walker; Fiscal Year: 2013
    ..These efforts are essential to understand why some CTL are more efficient and others less efficient in their antiviral function and are necessary to develop effective vaccines that generate optimal immune responses against HIV-1. ..
  38. Cloning of the vic1 gene, a novel retrovirus restriction factor
    Tatyana V Golovkina; Fiscal Year: 2012
    Retroviruses cause lethal diseases in humans such as acquired immunodeficiency syndrome and T-cell leukemia by defeating host immune responses...
  39. Broad-range Inhibitors of Human Immunodeficiency Virus Entry
    Joseph G Sodroski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human immunodeficiency virus (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS)...
  40. Characterization of Nef vesicles and their effect on T cells and macrophage
    Michael D Powell; Fiscal Year: 2012
    ..type 1 (HIV-1) results in dysregulation and the ultimate depletion of the immune system known as Acquired Immunodeficiency Syndrome (AIDS)...
  41. Examining Trans-infection of HIV in Isolated Dendritic Cells
    Sheila M Barry; Fiscal Year: 2010
    ..This proposal will answer important questions about the mechanism of HIV capture and storage by DCs, thereby contributing to the overall understanding of the HIV:DC interaction. ..
  42. HIV-Induced CD4 T-Cell Depletion: An Innate Host Defense Gone Awry?
    Warner C Greene; Fiscal Year: 2013
    ..This approach could form a strong adjunct to traditional antiviral therapy and might be particularly beneficial for patients exhibiting broad drug resistance or rapid progression of disease. ..
  43. Biochemical and Biophysical Characterization of HIV Env Trimer Spikes using Nanod
    Carlos Enrique Catalano; Fiscal Year: 2011
    ..DESCRIPTION (provided by applicant): The Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immunodeficiency Syndrome, a devastating infection that has reached pandemic proportions...
  44. Identification of Novel Inhibitors of Human Papillomoavirus Infection
    TARA WALHART; Fiscal Year: 2013
    ....
  45. Synergy between SIV & Salmonella Infection
    ANDREAS J BAUMLER; Fiscal Year: 2010
    ..However, NTS cause bacteremia in patients with acquired immunodeficiency syndrome (AIDS)...
  46. Exploring Transitions in Sexual Decision-Making, Urban African American Women
    ANN KIKI ANAEBERE; Fiscal Year: 2010
    ..provided by applicant): African American women account for more than 66% of the estimated Acquired Immunodeficiency Syndrome (AIDS)/Human Immunodeficiency Virus (HIV) cases among women nationally...
  47. MECHANISM AND INHIBITION OF HIV REVERSE TRANSCRIPTASE
    Karen S Anderson; Fiscal Year: 2013
    ..stranded RNA genome and is considered the major etiological agent involved in the development of acquired immunodeficiency syndrome or AIDS...
  48. Structure and Molecular Composition of KSHV an RRV
    DEAN KEDES; Fiscal Year: 2009
    ..The results of our proposed studies on viral structure, molecular composition and assembly may help identify new targets for therapeutic intervention in the future. ..
  49. HIV-1 ENVELOPE GLYCOPROTEINS
    Joseph G Sodroski; Fiscal Year: 2013
    Human immunodeficiency virus (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS)...
  50. Proteomic Tools to Uncover the Role of Chromatin Remodeling in HIV-1 Infection
    Ileana M Cristea; Fiscal Year: 2012
    ..provided by applicant): With a genetic capacity of only 104 bp, HIV has triggered the devastating acquired immunodeficiency syndrome (AIDS) epidemic...
  51. The Development of Immune-based Therapies Using Plant Derived Compounds to Attenu
    MARINA PESTOVA; Fiscal Year: 2010
    ..We believe that our potential product will be used either alone, as an initial therapy for newly diagnosed patients, or in combination with current antiviral drugs. ..
  52. Routine HIV Testing in Primary Care Practices
    Emma M Simmons; Fiscal Year: 2010
    ..goal will be to evaluate routine HIV testing in primary care patients as a method of eradicating Acquired Immunodeficiency Syndrome. This award would allow me to obtain additional experience in clinical research methodology ..
  53. HIV Proteomic Center for Host-Viral Response Characterization
    Richard D Smith; Fiscal Year: 2010
    ..Project 3: To evaluate the immunomodulatory effects of heroin, buprenorphine, and protease inhibitors in opioid-dependent individuals, infected or not with HIV. ..
  54. A method for the design of low-cost paper-based point-of-care diagnostic devices
    NATHAN DAVID SHAPIRO; Fiscal Year: 2012
    ..Twenty-five years ago it was discovered that acquired immunodeficiency syndrome (AIDS) is caused by HIV. Despite that knowledge, no cure has yet been developed...
  55. Nicotine & Immunopathogenesis of Cryptococcal meningitis
    Mohan Sopori; Fiscal Year: 2007
    ..by applicant): Opportunistic infections of the central nervous system are common complication in acquired immunodeficiency syndrome (AIDS) patients...
  56. Phenotypic and genetic effects of antiretroviral therapy on human oral epithelium
    MO KWAN KANG; Fiscal Year: 2012
    ..oral mucosal health in the patients affected by human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS)...
  57. Product Development and Manufacture
    ROBERT T MCNALLY; Fiscal Year: 2011
    The acquired immunodeficiency syndrome (AIDS) caused by HIV-1 is the leading cause of death in Africa and the fourth leading cause of death worldwide...
  58. Generating SEVI disaggregases to prevent HIV infection
    James Shorter; Fiscal Year: 2013
    ..abstract_text> ..
  59. MURINE MODEL OF IMMUNOSUPPRESSION INDUCED CMV RETINITIS
    Patrick Cleveland; Fiscal Year: 1991
    ....
  60. Host Cell Factors and AIDS Pathogenesis
    GHALIB ABBAS ALKHATIB; Fiscal Year: 2013
    ..Since HIV is the virus that causes acquired immunodeficiency syndrome (AIDS), the basic knowledge of these HIV viruses will provide an important new insight into AIDS ..
  61. CRYPTOSPORIDIUM DHFR AS A CHEMOTHERAPEUTIC TARGET
    Richard Nelson; Fiscal Year: 1992
    ..CR, a coccidian parasite, causes diarrheal disease in 15 percent of acquired immunodeficiency syndrome (AIDS) patients in the United States, and up to 50 percent of AIDS in developing nations...
  62. Advancing our Understanding of Rare Pediatric Liver Diseases
    KATHLEEN MARY LOOMES; Fiscal Year: 2013
    ..The ultimate gains are obvious both for individual patients and in terms of health care dollars. ..
  63. AIDS ASSOCIATED LEUKOPLAKIA--ROLE OF EBV
    Nancy Raab Traub; Fiscal Year: 2004
    ..oral lesion known as "hairy" leukoplakia (HLP), which is a harbinger for the development of the acquired immunodeficiency syndrome (AIDS)...
  64. DICATIONIC DRUGS--TREATMENT FOR AIDS-RELATED INFECTIONS
    Richard Tidwell; Fiscal Year: 1999
    The Acquired Immunodeficiency Syndrome (AIDS) continues to be a major health problem in the United States and around the world...
  65. CMV ACCESSORY GENES AND RETINAL CELL INFECTION
    Lenore Pereira; Fiscal Year: 1999
    ..VZV), and herpes simplex virus 1 (HSV-1), is the major cause of vision loss in patients with the acquired immunodeficiency syndrome (AIDS)...
  66. INHIBITING TRANSACTIVATION OF HIV-1
    Robert Ricciardi; Fiscal Year: 1992
    Human immunodeficiency virus (HIV) is the primary etiological agent of acquired immunodeficiency syndrome (AIDS)...
  67. Bone marrow monocyte output and virus import into the CNS in acute SIV infection
    Michael McChesney; Fiscal Year: 2009
    ..inflammation and functionality of newly emerging monocytes in the rhesus macaque animal model for Acquired Immunodeficiency Syndrome (AIDS)...
  68. MECHANISM BASED DRUG SELECTION AND DESIGN FOR T GONDII
    Keith Joiner; Fiscal Year: 1999
    ..Toxoplasma gondii is the leading cause of focal central nervous system infections in patients with the acquired immunodeficiency syndrome (AIDS). The limited repertoire of therapeutic agents for T...
  69. MULTIFUNCTIONAL PHOSPHONOFORMATE PRODRUGS AGAINST HIV 1
    Andre Rosowsky; Fiscal Year: 1993
    ..Compounds showing enough activity in vitro will be resynthesized for in vivo testing by Dr. Ruprecht as part of her active work on new anti-AIDS drugs in relevant murine models such as HIV-1 infected chimeric SCID mice...
  70. Predictive QSAR Modeling of HIV-1 Integrase Inhibitors
    Rajni Garg; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): HIV-1 drug-resistance is a growing public health problem. Acquired Immunodeficiency Syndrome (AIDS) and its related disorders, caused by retrovirus Human Immunodeficiency Virus Type 1 (HIV-1), are ..
  71. RESISTANCE OF OPPORTUNISTIC INFECTION BY MYCOBACTERIA
    D Blanchard; Fiscal Year: 1992
    ..In patients with the Acquired Immunodeficiency Syndrome (AIDS), where the immune response is severely depressed, a disseminated form of MAI is found in over ..
  72. CYTOMETRIC CD4 COUNTING - A MINIMALIST APPROACH
    Howard Shapiro; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  73. MURINE MODEL OF HIV INFECTION OF HUMAN BRAIN
    Cristian Achim; Fiscal Year: 1999
    DESCRIPTION (adapted from the Abstract): Approximately one quarter of patients with the acquired immunodeficiency syndrome (AIDS) develop neurologic symptoms attributable to human immunodeficiency virus, Type 1 (HIV) infection within the ..