marburg virus disease

Summary

Summary: An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.

Top Publications

  1. ncbi Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes
    Michael Hevey
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 2170, USA
    Virology 314:350-7. 2003
  2. ncbi Lessons from nosocomial viral haemorrhagic fever outbreaks
    Susan P Fisher-Hoch
    Department of Epidemiology, University of Texas Houston Health Science Center, School of Public Health, Brownsville Campus, Brownsville, TX, USA
    Br Med Bull 73:123-37. 2005
  3. ncbi Marburg hemorrhagic fever--the forgotten cousin strikes
    Heinz Feldmann
    Special Pathogens Program at the National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
    N Engl J Med 355:866-9. 2006
  4. ncbi The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. I. Lessons learned in the hospital
    Benjamin Jeffs
    Medecins Sans Frontieres, Barcelona, CP 08001, Spain
    J Infect Dis 196:S154-61. 2007
  5. pmc Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007
    Jennifer Adjemian
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 2665, USA
    J Infect Dis 204:S796-9. 2011
  6. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009
  7. pmc Ebola and Marburg hemorrhagic fevers: neglected tropical diseases?
    Adam MacNeil
    Viral Special Pathogens Branch, The Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Negl Trop Dis 6:e1546. 2012
  8. ncbi Defense against filoviruses used as biological weapons
    Mike Bray
    Medical Officer, Biodefense Clinical Research Branch, OCR OD NIAID NIH, 6700A Rockledge Drive, Room 5132, Bethesda, MD 20892, USA
    Antiviral Res 57:53-60. 2003
  9. pmc The use of a mobile laboratory unit in support of patient management and epidemiological surveillance during the 2005 Marburg Outbreak in Angola
    Allen Grolla
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Negl Trop Dis 5:e1183. 2011
  10. pmc Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections
    Thomas W Geisbert
    Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77550 0610, USA
    J Infect Dis 204:S1075-81. 2011

Research Grants

  1. Structural Studies of Ebola Viral Pathogenesis
    ERICA SAPHIRE; Fiscal Year: 2003
  2. EBOLA VIRUS INTERFERON-ANTAGONISTS AND VIRULENCE
    CHRISTOPHER BASLER; Fiscal Year: 2003
  3. Lassa and Nipah Virus Interferon-Antagonists
    CHRISTOPHER BASLER; Fiscal Year: 2003

Detail Information

Publications142 found, 100 shown here

  1. ncbi Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes
    Michael Hevey
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 2170, USA
    Virology 314:350-7. 2003
    ..These data suggest that neutralizing epitopes exist within MBGV GP but that induction of antibodies to these neutralizing epitopes may not be sufficient for protection from lethal infection...
  2. ncbi Lessons from nosocomial viral haemorrhagic fever outbreaks
    Susan P Fisher-Hoch
    Department of Epidemiology, University of Texas Houston Health Science Center, School of Public Health, Brownsville Campus, Brownsville, TX, USA
    Br Med Bull 73:123-37. 2005
    ..Educating the public to demand higher standards could be a powerful tool. Good practices are difficult to establish and maintain on the scale needed...
  3. ncbi Marburg hemorrhagic fever--the forgotten cousin strikes
    Heinz Feldmann
    Special Pathogens Program at the National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
    N Engl J Med 355:866-9. 2006
  4. ncbi The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. I. Lessons learned in the hospital
    Benjamin Jeffs
    Medecins Sans Frontieres, Barcelona, CP 08001, Spain
    J Infect Dis 196:S154-61. 2007
    ..More interventional medical care may not only improve survival but also improve acceptability...
  5. pmc Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007
    Jennifer Adjemian
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 2665, USA
    J Infect Dis 204:S796-9. 2011
    ..We describe the epidemiologic investigation and the health education response...
  6. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009
    ..These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans...
  7. pmc Ebola and Marburg hemorrhagic fevers: neglected tropical diseases?
    Adam MacNeil
    Viral Special Pathogens Branch, The Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Negl Trop Dis 6:e1546. 2012
    ....
  8. ncbi Defense against filoviruses used as biological weapons
    Mike Bray
    Medical Officer, Biodefense Clinical Research Branch, OCR OD NIAID NIH, 6700A Rockledge Drive, Room 5132, Bethesda, MD 20892, USA
    Antiviral Res 57:53-60. 2003
    ..Terrorists might have great difficulty acquiring a filovirus for use as a weapon, but my attempt to do so because of the agents' ability to inspire fear. Accurate information is the best tool to prevent panic in the event of an attack...
  9. pmc The use of a mobile laboratory unit in support of patient management and epidemiological surveillance during the 2005 Marburg Outbreak in Angola
    Allen Grolla
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Negl Trop Dis 5:e1183. 2011
    ..Marburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever (MHF) with the highest case fatality rate to date...
  10. pmc Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections
    Thomas W Geisbert
    Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77550 0610, USA
    J Infect Dis 204:S1075-81. 2011
    ..Here, we review the history of rVSV-based vaccines and pivotal animal studies showing their utility in combating Ebola and Marburg virus infections...
  11. pmc Marburg virus infection detected in a common African bat
    Jonathan S Towner
    Centers for Disease Control and Prevention, Special Pathogens Branch, Atlanta, Georgia, United States of America
    PLoS ONE 2:e764. 2007
    ..These data imply that more areas are at risk for MHF outbreaks than previously realized and correspond well with a recently published report in which three species of fruit bats were demonstrated to be likely reservoirs for Ebola virus...
  12. ncbi Ebola and marburg hemorrhagic fever
    Amy L Hartman
    University of Pittsburgh, Center for Vaccine Research, PA 15261, USA
    Clin Lab Med 30:161-77. 2010
    ....
  13. ncbi Is Marburg virus enzootic in Gabon?
    Gael D Maganga
    Centre International de Recherches Medicales de Franceville, Gabon
    J Infect Dis 204:S800-3. 2011
    ....
  14. ncbi Ecology of Marburg and Ebola viruses: speculations and directions for future research
    T P Monath
    Research and Medical Affairs, OraVax, Inc, Cambridge Massachusetts 02139, USA
    J Infect Dis 179:S127-38. 1999
    ..Such viruses may have separate life cycles or may give rise to virulent strains by mutation...
  15. ncbi Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses
    Dana L Swenson
    US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702 5011, USA
    Expert Rev Vaccines 7:417-29. 2008
    ..Guinea pigs vaccinated with Marburg virus VLPs (mVLPs) or inactivated MARV (iMARV) develop homologous humoral and T-cell responses and are completely protected from a lethal homologous MARV challenge...
  16. ncbi De novo syntheses of Marburg virus antigens from adenovirus vectors induce potent humoral and cellular immune responses
    Danher Wang
    Division of Biodefense Vaccines, GenPhar Inc, 871 Lowcountry Blvd, Mount Pleasant, SC 29464, USA
    Vaccine 24:2975-86. 2006
    ..These promising results indicate that a cAdVax-based vaccine could be effective for induction of both humoral and cell-mediated immune responses to multiple strains of the Marburg virus...
  17. pmc Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection
    Brian R Amman
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002877. 2012
    ..aegyptiacus bats existing as a large meta-population with associated virus circulation over broad geographic ranges. These findings provide a basis for developing Marburg hemorrhagic fever risk reduction strategies...
  18. ncbi The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. II. lessons learned in the community
    Paul Roddy
    Medecins Sans Frontieres, Barcelona, CP 08001, Spain
    J Infect Dis 196:S162-7. 2007
    ..Actively involving all stakeholders from the start of the outbreak response is crucial...
  19. pmc Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G14, Atlanta, GA 30333, USA
    J Virol 80:6497-516. 2006
    ..This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus genetic lineages (with up to 21% divergence) and multiple virus introductions into the human population was found...
  20. ncbi Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions
    Daniel G Bausch
    Tulane University Health Sciences Center, New Orleans, LA, United States
    Antiviral Res 78:150-61. 2008
    ..Here, we review the present research priorities and environment for field study of the filovirus hemorrhagic fevers and outline a strategy for future prospective clinical research on treatment and vaccine prevention...
  21. pmc Postexposure treatment of Marburg virus infection
    Thomas W Geisbert
    National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts 02118, USA
    Emerg Infect Dis 16:1119-22. 2010
    ..We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection...
  22. ncbi Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    J Infect Dis 196:S421-9. 2007
    ..The goal of this work was to increase the yield of VLPs, while retaining their immunogenic properties...
  23. ncbi Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus
    Jenny Riemenschneider
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 21:4071-80. 2003
    ....
  24. ncbi Functional CD8+ T cell responses in lethal Ebola virus infection
    Steven B Bradfute
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    J Immunol 180:4058-66. 2008
    ..These findings should cause a change in the current view of the 'impaired' immune response to EBOV challenge and may help spark new therapeutic strategies to control lethal filovirus disease...
  25. ncbi Pathogenesis of Marburg hemorrhagic fever in cynomolgus macaques
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Infect Dis 204:S1021-31. 2011
    ..In this study we evaluated the progression of MARV infection in nonhuman primates...
  26. ncbi Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges
    Danher Wang
    Division of Bio defense Vaccines, GenPhar Inc, 871 Lowcountry Blvd, Mount Pleasant, SC 29464, USA
    Virology 353:324-32. 2006
    ..Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV...
  27. ncbi Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates
    M Hevey
    United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland, 21702, USA
    Virology 251:28-37. 1998
    ..Three monkeys vaccinated with replicons which expressed MBGV GP, and three others vaccinated with both replicons that expressed GP or NP, remained aviremic and were completely protected from disease...
  28. ncbi [Democratic Republic of the Congo: between civil war and the Marburg virus. International Committee of Technical and Scientific Coordination of the Durba Epidemic]
    E Bertherat
    Service de médecine des collectivités, l Hôpital d instruction des armées Laveran, Marseille, France
    Med Trop (Mars) 59:201-4. 1999
    ..When an epidemic of Marburg virus disease occurred in the Durba region located in the northeastern part of the People's Republic of the Congo, 23 ..
  29. ncbi [Ebola and Marburg hemorrhagic fever viruses: update on filoviruses]
    E Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Med Trop (Mars) 71:111-21. 2011
    ..The purpose of this review is to present the main developments in these particular fields in the last decade...
  30. ncbi Development and evaluation of a fluorogenic 5'-nuclease assay to identify Marburg virus
    T R Gibb
    Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA
    Mol Cell Probes 15:259-66. 2001
    ..In addition, this assay is compatible with emerging rapid nucleic acid analysis platforms and therefore may prove to be a useful diagnostic tool for the control and management of future outbreaks...
  31. pmc Development and evaluation of a simple assay for Marburg virus detection using a reverse transcription-loop-mediated isothermal amplification method
    Yohei Kurosaki
    National Research Institute of Police Science, Kashiwa, Japan
    J Clin Microbiol 48:2330-6. 2010
    ..Furthermore, it seems suitable for use for field diagnostics or in laboratories in areas where MARV is endemic...
  32. ncbi Genomic differences between guinea pig lethal and nonlethal Marburg virus variants
    Loreen L Lofts
    Viral Pathogenesis and Immunology Branch, Virology Division, US Army Medical Research Institute for Infectious Diseases, Frederick, MD 21702, USA
    J Infect Dis 196:S305-12. 2007
    ..The L gene mutations were equally intriguing, clustering near a highly conserved motif in viral RNA-dependent RNA polymerases...
  33. ncbi Breakdown of paraendothelial barrier function during Marburg virus infection is associated with early tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1
    Michael Böckeler
    Institute of Physiology, Technical University, Dresden, D 01307, Germany
    J Infect Dis 196:S337-46. 2007
    ....
  34. ncbi Laboratory diagnosis of Ebola and Marburg hemorrhagic fever
    A Grolla
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Bull Soc Pathol Exot 98:205-9. 2005
    ..In addition, the role of field-based laboratory support and its limitations and capabilities in an outbreak response setting, especially in regards to real-time PCR and immunofiltration assays, is presented...
  35. pmc A small nonhuman primate model for filovirus-induced disease
    Ricardo Carrion
    Department of Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227, USA
    Virology 420:117-24. 2011
    ..Lymphoid necrosis and lymphocytic depletion observed in spleen. These findings provide support for the use of the common marmoset as a small nonhuman primate model for filovirus induced hemorrhagic fever...
  36. pmc Progress in filovirus vaccine development: evaluating the potential for clinical use
    Darryl Falzarano
    Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Expert Rev Vaccines 10:63-77. 2011
    ..These results demonstrate that achieving a vaccine that is protective against filoviruses is possible; the challenge now is to prove its safety and efficacy in order to obtain a vaccine that is ready for human use...
  37. pmc Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo
    Daniel G Bausch
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 9:1531-7. 2003
    ..Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus...
  38. pmc Prospects for immunisation against Marburg and Ebola viruses
    Thomas W Geisbert
    Galveston National Laboratory1 and Department of Microbiology and Immunology2, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA
    Rev Med Virol 20:344-57. 2010
    ..The rVSV-based vaccine has also shown utility when administered for postexposure prophylaxis against filovirus infections. A VSV-based Ebola vaccine was recently used to manage a potential laboratory exposure...
  39. pmc Cross-protection against Marburg virus strains by using a live, attenuated recombinant vaccine
    Kathleen M Daddario-DiCaprio
    Virology Division, USAMRIID, Fort Detrick, MD 21702 5011, USA
    J Virol 80:9659-66. 2006
    ..These data suggest that the VSVDeltaG/MARVGP-Musoke vaccine should be sufficient to protect against all known MARV strains...
  40. pmc Marburg virus evades interferon responses by a mechanism distinct from ebola virus
    Charalampos Valmas
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Pathog 6:e1000721. 2010
    ..It identifies a novel function for the MARV VP40 protein and suggests that MARV may globally inhibit Jak1-dependent cytokine signaling...
  41. ncbi Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment
    Kathleen M Daddario-DiCaprio
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Lancet 367:1399-404. 2006
    ..We aimed to test the efficacy of a replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus (rVSV), as a postexposure treatment for MARV haemorrhagic fever...
  42. pmc Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus
    Thomas W Geisbert
    Department of Microbiology, National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Virol 83:7296-304. 2009
    ..In conclusion, we developed an immunization scheme based on a single-injection vaccine that protects nonhuman primates against lethal challenge with representative strains of all human pathogenic filovirus species...
  43. ncbi Marburg virus Angola infection of rhesus macaques: pathogenesis and treatment with recombinant nematode anticoagulant protein c2
    Thomas W Geisbert
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA
    J Infect Dis 196:S372-81. 2007
    ....
  44. pmc Evasion of interferon responses by Ebola and Marburg viruses
    Christopher F Basler
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Interferon Cytokine Res 29:511-20. 2009
    ..Thus, despite their similarities, there are fundamental differences by which these deadly viruses counteract the IFN system. It will be of interest to determine how these differences influence pathogenesis...
  45. pmc Vaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections
    Dana L Swenson
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Vaccine Immunol 15:460-7. 2008
    ..This study indicates the feasibility of vaccination against all current filovirus threats in the event of natural hemorrhagic fever outbreak or biological attack...
  46. pmc Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Virol 84:10386-94. 2010
    ....
  47. pmc Response to imported case of Marburg hemorrhagic fever, the Netherland
    Aura Timen
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:1171-5. 2009
    ..We present lessons learned and results of the follow-up serosurvey of contacts and focus on factors that prevented overreaction during an event with a high public health impact...
  48. ncbi Advanced antisense therapies for postexposure protection against lethal filovirus infections
    Travis K Warren
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Nat Med 16:991-4. 2010
    ..PMOplus may be useful for treating these and other highly pathogenic viruses in humans...
  49. pmc Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses
    Thomas W Geisbert
    National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, MA, USA
    Vaccine 26:6894-900. 2008
    ..Interestingly, disease in control animals appeared to progress slower than previously seen in macaques exposed to comparable doses by intramuscular injection...
  50. ncbi Marburg hemorrhagic fever associated with multiple genetic lineages of virus
    Daniel G Bausch
    Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 355:909-19. 2006
    ..An outbreak of Marburg hemorrhagic fever was first observed in a gold-mining village in northeastern Democratic Republic of the Congo in October 1998...
  51. ncbi Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy
    T W Geisbert
    Pathology Division, United States Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Ultrastruct Pathol 22:3-17. 1998
    ..This case demonstrates the value of transmission electron microscopy as a tool for assisting in the definitive diagnosis of Marburg or Ebola hemorrhagic fever, as well as providing insight into the pathogenesis of these agents...
  52. ncbi Rapid detection protocol for filoviruses
    Manfred Weidmann
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Street 11, 79104 Freiburg, Germany
    J Clin Virol 30:94-9. 2004
    ..Apart from family members of infected patients, health care workers are at high risk of being infected during the initial phase of an outbreak. RT-PCR has been shown to be helpful in containing outbreaks...
  53. pmc Enzyme-linked immunosorbent assays for detection of antibodies to Ebola and Marburg viruses using recombinant nucleoproteins
    M Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama, Tokyo 208 0011, Japan
    J Clin Microbiol 39:1-7. 2001
    ..The results indicate that ELISA systems prepared with the recombinant NPs of EBO and MBG are valuable tools for the diagnosis of EBO and MBG infections and for seroepidemiological field studies...
  54. pmc Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola
    Paul Roddy
    Médecins Sans Frontières Spain, Barcelona, Spain
    J Infect Dis 201:1909-18. 2010
    ..Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)-recommended case definitions for MHF...
  55. ncbi Vaccine research efforts for filoviruses
    Mary Kate Hart
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Int J Parasitol 33:583-95. 2003
    ..The vaccine approaches discussed include DNA-based vaccines, and subunit vaccines vectored by adenovirus, alphavirus replicons, and vaccinia virus...
  56. pmc Antiviral activity of a small-molecule inhibitor of filovirus infection
    Travis K Warren
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    Antimicrob Agents Chemother 54:2152-9. 2010
    ..Taken together, these results identify a promising antiviral therapeutic candidate for the treatment of filovirus infections...
  57. ncbi Marburgvirus nucleoprotein-capture enzyme-linked immunosorbent assay using monoclonal antibodies to recombinant nucleoprotein: detection of authentic Marburgvirus
    Masayuki Saijo
    Department of Virology 1, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 59:323-5. 2006
    ..These results suggest that the Ag-capture ELISA using the monoclonal antibodies, 2A7 and 2H6, is applicable to the diagnosis of MHF...
  58. ncbi Cellular immune response to Marburg virus infection in cynomolgus macaques
    Elizabeth A Fritz
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Viral Immunol 21:355-63. 2008
    ..IL-6 production was detected late in the infection in CD14(+) spleen cells. These results suggest a robust innate immune response to MARV; however, this response was delayed relative to the infection...
  59. ncbi Status and challenges of filovirus vaccines
    Douglas S Reed
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 25:1923-34. 2007
    ..Nevertheless, nonhuman primate studies have shown that protection against Marburg and Ebola is possible and there is hope that one day a vaccine will be licensed for human use...
  60. pmc Development of a model for marburgvirus based on severe-combined immunodeficiency mice
    Kelly L Warfield
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Virol J 4:108. 2007
    ..Also, as shown here, the scid-adapted MARV mouse models can be used to evaluate the efficacy of candidate antiviral therapeutic molecules, such as phosphorodiamidate morpholino oligomers or antibodies...
  61. ncbi Pathogenesis of filoviral haemorrhagic fevers
    Siddhartha Mahanty
    Malaria Vaccine Development Unit, at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Lancet Infect Dis 4:487-98. 2004
    ..Recent studies in non-human primates have shown that blocking of certain host responses, such as the coagulation cascade, can result in reduced viral replication and improved host survival...
  62. pmc Development and characterization of a mouse model for Marburg hemorrhagic fever
    Kelly L Warfield
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    J Virol 83:6404-15. 2009
    ..This mouse-adapted MARV strain can now be used to develop and evaluate novel vaccines and therapeutics and may also help to provide a better understanding of the virulence factors associated with MARV...
  63. ncbi Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment
    Robert Colebunders
    Institute of Tropical Medicine Antwerp, Antwerp, B 2000, Belgium
    J Infect Dis 196:S148-53. 2007
    ..Treatment in isolation wards was acceptable, but the quality of clinical documentation was unsatisfactory. Improved clinical documentation is necessary for a basic evaluation of supportive treatment...
  64. pmc Disease modeling for Ebola and Marburg viruses
    Dennis Bente
    Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Dis Model Mech 2:12-7. 2009
    ....
  65. ncbi Marburg virus-like particles protect guinea pigs from lethal Marburg virus infection
    Kelly L Warfield
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702 5011, USA
    Vaccine 22:3495-502. 2004
    ..Taken together with our previous work, these findings suggest that VLPs are a promising vaccine candidate for the deadly filovirus infections...
  66. ncbi Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic Fever in cynomolgus macaques
    D A Alves
    Center for Vaccine Research, University of Pittsburgh, 8037 BST3, 3051 Fifth Avenue, Pittsburgh, PA 15261, USA
    Vet Pathol 47:831-51. 2010
    ..These macaques exhibited a number of features similar to those of human filovirus infections; as such, this model of aerosolized MARV-Angola might be useful in developing medical countermeasures under the Animal Rule...
  67. ncbi Basic clinical and laboratory features of filoviral hemorrhagic fever
    Mark G Kortepeter
    Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 5119, USA
    J Infect Dis 204:S810-6. 2011
    ..By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks...
  68. pmc Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences
    JOHN MISASI
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Virol 86:3284-92. 2012
    ..These studies strongly suggest that the use of endosomal cysteine proteases as host factors for entry is a general property of members of the family Filoviridae...
  69. pmc Filoviral immune evasion mechanisms
    Parameshwaran Ramanan
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA
    Viruses 3:1634-49. 2011
    ..The examples also represent distinct mechanisms utilized by filoviral proteins in order to counter immune responses, which results in limited IFN-α/β production and downstream signaling...
  70. ncbi Filovirus infection of STAT-1 knockout mice
    Jolynne Raymond
    Department of Veterinary Pathology, Armed Forces Institutes of Pathology, Washington, District of Columbia, USA
    J Infect Dis 204:S986-90. 2011
    ..A virus-like particle vaccine elicited strong antibody responses but did not protect against mouse-adapted ZEBOV challenge...
  71. pmc Protective role of cytotoxic T lymphocytes in filovirus hemorrhagic fever
    Kelly Lyn Warfield
    Vaccine Development, Integrated BioTherapeutics, Inc, 21 Firstfield Road Suite 100, Gaithersburg, MD 20878, USA
    J Biomed Biotechnol 2011:984241. 2011
    ..Advancements in assays and technologies may allow these studies to occur during future outbreaks...
  72. ncbi Progress in recombinant DNA-derived vaccines for Lassa virus and filoviruses
    Rebecca J Grant-Klein
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Virus Res 162:148-61. 2011
    ..In this review, we consider the status of various recombinant DNA candidate vaccines against Lassa virus and filoviruses which have been tested in animals...
  73. pmc Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid protein VP30
    Sven Enterlein
    Department of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Virol 80:1038-43. 2006
    ..In contrast, rescue of recombinant EBOV was not supported by EBOV VP30 containing a mutated Zn-binding domain...
  74. ncbi Lethality and pathogenesis of airborne infection with filoviruses in A129 α/β -/- interferon receptor-deficient mice
    Mark S Lever
    Defence Science and Technology Laboratories Dstl, Porton Down, Salisbury, Wiltshire, UK
    J Med Microbiol 61:8-15. 2012
    ..The KO mouse may provide a useful model to test potential antiviral therapeutics against wild-type filoviruses...
  75. ncbi Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Clin Microbiol Infect 17:964-76. 2011
    ..As a result, our understanding of the ecology, host interactions, and control of these viruses has improved considerably...
  76. pmc Key genomic changes necessary for an in vivo lethal mouse marburgvirus variant selection process
    Loreen L Lofts
    USAMRIID, Virology Division, 1425 Porter Street, Frederick, MD 21702, USA
    J Virol 85:3905-17. 2011
    ..These studies provide insights into how marburgviruses manipulate the host for enzymes, metabolites, translation regulators, and effectors of the innate immune response to serve as potential viral countermeasures...
  77. pmc Serosurvey on household contacts of Marburg hemorrhagic fever patients
    Matthias Borchert
    Institute of Tropical Medicine, Antwerp, Belgium
    Emerg Infect Dis 12:433-9. 2006
    ..The secondary attack risk was 21%; the postintervention reproduction number was 0.9, consistent with an outbreak sustained by repeated primary transmission, rather than large-scale secondary transmission...
  78. pmc VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment
    Larissa Kolesnikova
    Institut für Virologie der Philipps Universität Marburg, D 35037 Marburg, Germany
    J Virol 76:1825-38. 2002
    ..Our data indicate that MBGV VP40 was able to interact with membranes of late endosomes in the course of viral infection. This capability was independent of other MBGV proteins...
  79. ncbi Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever
    Judith van Paassen
    Department of Intensive Care, Leiden University Medical Center, Leiden, Netherlands
    Lancet Infect Dis 12:635-42. 2012
    ..Aggressive critical-care treatment with renal replacement therapy and use of the molecular absorbent recirculation system appeared able to stabilise--at least temporarily--the patient's condition...
  80. pmc Discovery of common marburgvirus protective epitopes in a BALB/c mouse model
    Warren V Kalina
    Division of Bacteriology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Fort Detrick, Maryland, 21702, USA
    Virol J 6:132. 2009
    ..In our study, we infected BALB/c mice with plaque-purified, nonlethal MARV and used overlapping peptides to map H2d-restricted CD8+ T-cell epitopes...
  81. ncbi Geographic potential for outbreaks of Marburg hemorrhagic fever
    A Townsend Peterson
    Natural History Museum and Biodiversity Research Center, University of Kansas, Lawrence, Kansas 66047, USA
    Am J Trop Med Hyg 75:9-15. 2006
    ..Overall, results demonstrate that ecologic niche modeling can be a powerful tool in understanding geographic distributions of species and other biologic phenomena such as zoonotic disease transmission from natural reservoir populations...
  82. ncbi Basolateral budding of Marburg virus: VP40 retargets viral glycoprotein GP to the basolateral surface
    Larissa Kolesnikova
    Institute for Virology, Philipps Universitat Marburg, Marburg, Germany
    J Infect Dis 196:S232-6. 2007
    ..This redistribution is a prerequisite for budding of infectious virions from the basolateral domain...
  83. ncbi Short communication: a cluster of Marburg virus disease involving an infant
    Matthias Borchert
    Epidemiology Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 7:902-6. 2002
    ..The findings show that mild cases of MHF have to be expected during an outbreak and point out the difficulty to base patient management decisions on clinical case definitions alone...
  84. pmc Ecologic and geographic distribution of filovirus disease
    A Townsend Peterson
    Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, USA
    Emerg Infect Dis 10:40-7. 2004
    ..This first large-scale ecologic analysis provides a framework for a more informed search for taxa that could constitute the natural reservoir for this virus family...
  85. ncbi [Ebola virus and Marburg virus]
    Shigeru Morikawa
    Department of Virology I, National Institute of Infectious Diseases
    Nihon Rinsho 61:544-9. 2003
  86. ncbi [How to treat a patient with indications for an infectious viral hemorrhagic fever]
    L G Visser
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:2183-8. 2002
    ..Using this approach it is possible to diagnose high-risk patients in good time and to take appropriate measures...
  87. ncbi Ebola virus ecology: a continuing mystery
    Heinz Feldmann
    Special Pathogens Program, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Trends Microbiol 12:433-7. 2004
  88. ncbi [Viral hemorrhagic fevers--Ebola hemorrhagic fever, Marburg virus disease, and Lassa fever]
    Kiyosu Taniguchi
    Nihon Naika Gakkai Zasshi 93:2303-8. 2004
  89. ncbi Other viral bioweapons: Ebola and Marburg hemorrhagic fever
    Michelle R Salvaggio
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 1900 University Boulevard, 229 Tinsley Harrison Tower, Birmingham, AL 35294, USA
    Dermatol Clin 22:291-302, vi. 2004
    ..Herein we discuss the Filoviridae, the agents of Ebola and Marburg hemorrhagic fevers...
  90. pmc In the field, Canadians diagnose Marburg
    Laura Eggertson
    CMAJ 172:1430. 2005
  91. ncbi Vaccines against Ebola and Marburg viruses show promise in primate studies
    Tracy Hampton
    JAMA 294:163-4. 2005
  92. pmc Rapid molecular strategy for filovirus detection and characterization
    Junhui Zhai
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Clin Microbiol 45:224-6. 2007
    ..Phylogenetic assignment is achieved by automated web-based sequence analysis of amplification products...
  93. ncbi The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis
    H Feldmann
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    Arch Virol Suppl 15:159-69. 1999
    ..Whether the soluble glycoproteins GP1 and sGP interfere with the humoral immune response and other defense mechanisms remains to be determined...
  94. ncbi [Ebola and Marburg fever--outbreaks of viral haemorrhagic fever]
    R Chlibek
    Katedra epidemiologie Fakulty vojenského zdravotnictví Univerzity obrany, Hradec Kralove
    Klin Mikrobiol Infekc Lek 12:217-23. 2006
    ..For this reason, the public should be prepared for possible contact with these highly virulent infections...
  95. ncbi A clinical guide to viral haemorrhagic fevers: Ebola, Marburg and Lassa
    Benjamin Jeffs
    Medicens Sans Frontieres, Spain
    Trop Doct 36:1-4. 2006
    ..This article gives a brief overview of diseases caused by the Ebola, Marburg and Lassa viruses. It gives some practical advice to the clinician on the diagnosis and management of these diseases...
  96. ncbi Marburg fever in Angola: still a mystery disease
    Dorothy Bonn
    Lancet Infect Dis 5:331. 2005
  97. ncbi [Ebola and Marburg viruses: the humans strike back]
    Nathalie Alazard-Dany
    Laboratoire des Filovirus, INSERM U758, ENS Lyon, IFR 128 Biosciences Lyon Gerland, Universite Claude Bernard Lyon 1, France
    Med Sci (Paris) 22:405-10. 2006
    ..As for Jones SM et al., they have successfully vaccinated monkeys with recombinant vesicular stomatitis virus expressing Ebola or Marburg virus surface glycoprotein GP, a promising vaccine approach...
  98. pmc Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses
    Mansour Mohamadzadeh
    U S Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA
    J Virol 80:7235-44. 2006
    ..These data imply direct activation of TREM-1 by filoviruses and also indicate that neutrophils may play a prominent role in the immune and inflammatory responses to filovirus infections...
  99. ncbi In vitro evaluation of cyanovirin-N antiviral activity, by use of lentiviral vectors pseudotyped with filovirus envelope glycoproteins
    Laura G Barrientos
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 189:1440-3. 2004
    ..Our data emphasize both the utility of GP-pseudotyped vectors in the assessment of compounds that affect cell entry by filovirus and the use of CV-N as a reagent for the probing of carbohydrate-dependent interactions at viral entry...
  100. ncbi Poliomyelitis eradication and pandemic influenza
    David L Heymann
    Polio Eradication Initiative, World Health Organization, Geneva 27, Switzerland
    Lancet 367:1462-4. 2006
  101. ncbi Ebola and Marburg viruses: pathogenesis and development of countermeasures
    Lisa E Hensley
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Curr Mol Med 5:761-72. 2005
    ..In addition, substantial progress has been made in developing recombinant vaccines against these viruses...

Research Grants3

  1. Structural Studies of Ebola Viral Pathogenesis
    ERICA SAPHIRE; Fiscal Year: 2003
    ....
  2. EBOLA VIRUS INTERFERON-ANTAGONISTS AND VIRULENCE
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..VP35 and VP24 may also prove to be attractive targets for new antiviral agents. Inhibition of anti-IFN factors may sensitize Ebola virus infected cells to the antiviral effects of IFN and may also enhance the effect of antiviral agents. ..
  3. Lassa and Nipah Virus Interferon-Antagonists
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..abstract_text> ..