retroviridae infections

Summary

Summary: Virus diseases caused by the RETROVIRIDAE.

Top Publications

  1. pmc Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study
    Graham Simmons
    Blood Systems Research Institute and University of California, San Francisco, San Francisco, CA 94118, USA
    Science 334:814-7. 2011
  2. ncbi Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Vincent C Lombardi
    Whittemore Peterson Institute, Reno, NV 89557, USA
    Science 326:585-9. 2009
  3. pmc Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo
    Eri Takeda
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 82:10998-1008. 2008
  4. pmc No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e25592. 2011
  5. pmc Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies
    Xiaoxing Qiu
    Infectious Diseases R and D, Abbott Diagnostics, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Retrovirology 7:68. 2010
  6. pmc Historical perspective of foamy virus epidemiology and infection
    C D Meiering
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Microbiol Rev 14:165-76. 2001
  7. pmc No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
    Rika A Furuta
    Department of Research, Japanese Red Cross Osaka Blood Center, 2 4 43 Morinomiya, Joto ku, Osaka 536 8505, Japan
    Retrovirology 8:20. 2011
  8. ncbi The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response
    Gennadiy Zelinskyy
    Institute for Virology, University Clinics in Essen, University of Duisburg Essen, Essen, Germany
    Blood 114:3199-207. 2009
  9. pmc The mouse "xenotropic" gammaretroviruses and their XPR1 receptor
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Retrovirology 7:101. 2010
  10. pmc Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates
    William M Switzer
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:2780-9. 2004

Research Grants

  1. MARROW TRANSPLANT THERAPY FOR RETROVIRUS INFECTIONS
    PETER GASPER; Fiscal Year: 1992
  2. HIV & HTLV-I COHORT STUDIES OF HAITIAN WOMEN AND INFANTS
    Neal Halsey; Fiscal Year: 1991
  3. RETROVIRUS-HOST INTERACTIONS
    Harriet Robinson; Fiscal Year: 1992
  4. Feline Leukemia Virus Infection: A Model of Effective Retroviral Immunity
    Andrea Torres; Fiscal Year: 2007
  5. HPV and HTLV Infection in Female Sex Workers in Peru
    Joseph Zunt; Fiscal Year: 2009
  6. NONHUMAN PRIMATE AIDS SYMPOSIUM
    PETER GERONE; Fiscal Year: 1990
  7. NONHUMAN PRIMATE MODELS FOR AIDS SYMPOSIUM
    William Morton; Fiscal Year: 1991
  8. 10TH ANNL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AID
    Matthew Kessler; Fiscal Year: 1992
  9. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
  10. Determinants of Natural Host Resistance to SIV agm
    Jonathan Allan; Fiscal Year: 2005

Detail Information

Publications249 found, 100 shown here

  1. pmc Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study
    Graham Simmons
    Blood Systems Research Institute and University of California, San Francisco, San Francisco, CA 94118, USA
    Science 334:814-7. 2011
    ..These results indicate that current assays do not reproducibly detect XMRV/MLV in blood samples and that blood donor screening is not warranted...
  2. ncbi Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Vincent C Lombardi
    Whittemore Peterson Institute, Reno, NV 89557, USA
    Science 326:585-9. 2009
    ..These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS...
  3. pmc Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo
    Eri Takeda
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 82:10998-1008. 2008
    ..These results indicate, for the first time, that mouse APOBEC3 is a physiologically functioning restriction factor to mouse gammaretroviruses...
  4. pmc No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e25592. 2011
    ....
  5. pmc Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies
    Xiaoxing Qiu
    Infectious Diseases R and D, Abbott Diagnostics, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Retrovirology 7:68. 2010
    ..Development of assays to detect XMRV-specific antibodies would greatly facilitate such studies. However, the nature and kinetics of the antibody response to XMRV infection have yet to be determined...
  6. pmc Historical perspective of foamy virus epidemiology and infection
    C D Meiering
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Microbiol Rev 14:165-76. 2001
    ..In this communication, we briefly discuss the current status of FV research and review the history of FV epidemiology, as well as the lack of pathogenicity in natural, experimental, and zoonotic infections...
  7. pmc No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
    Rika A Furuta
    Department of Research, Japanese Red Cross Osaka Blood Center, 2 4 43 Morinomiya, Joto ku, Osaka 536 8505, Japan
    Retrovirology 8:20. 2011
    ..We also examined blood samples of viral antibody-positive patients with PC and all (both antibody-positive and antibody-negative) patients with CFS for XMRV DNA...
  8. ncbi The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response
    Gennadiy Zelinskyy
    Institute for Virology, University Clinics in Essen, University of Duisburg Essen, Essen, Germany
    Blood 114:3199-207. 2009
    ....
  9. pmc The mouse "xenotropic" gammaretroviruses and their XPR1 receptor
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Retrovirology 7:101. 2010
    ....
  10. pmc Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates
    William M Switzer
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:2780-9. 2004
    ..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections...
  11. pmc Cross-species transmission of simian foamy virus to humans in rural Gabon, Central Africa
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Virol 86:1255-60. 2012
    ..All but one were infected with ape SFV. We thus found novel SFV strains in NHPs in Gabon and high cross-species transmission of SFVs from gorilla bites...
  12. pmc Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points
    Kirsten K Dietze
    Institute for Virology, University Clinics Essen, University of Duisburg Essen, 45122 Essen, Germany
    Proc Natl Acad Sci U S A 108:2420-5. 2011
    ....
  13. pmc Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions
    Bryan P Danielson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 202:1470-7. 2010
    ..We therefore investigated whether XMRV infection could be found in patients with prostate cancer from the southern United States, and we sought to verify the association with the R462Q...
  14. pmc Retroviral superinfection resistance
    Micha Nethe
    Dept of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Retrovirology 2:52. 2005
    ..As primate models of SIV infection closely resemble HIV infection, a better knowledge of SIR-induced mechanisms could contribute to the development of an HIV vaccine or other antiviral strategies...
  15. pmc Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 82:408-18. 2008
    ..Coinfection of mice with LDV and FV provides a well-defined, natural host model for such studies...
  16. ncbi Characterization of blood-borne transmission of simian foamy virus
    James I Brooks
    National HIV and Retrovirology Laboratories, Center for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Transfusion 47:162-70. 2007
    ..This study examines whether SFV also shares the traits of transmissibility through the blood supply...
  17. pmc Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
    Yu An Zhang
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Cancer Biol Ther 12:617-28. 2011
    ..To investigate the frequency of xenotropic murine leukemia virus (MLV) presence in human cell lines established from mouse xenografts and to search for the evidence of horizontal viral spread to other cell lines...
  18. pmc Isolation and characterization of an equine foamy virus
    J Tobaly-Tapiero
    CNRS UPR9051, Universite Paris 7, Hopital Saint Louis, 75475 Paris Cedex 10, France
    J Virol 74:4064-73. 2000
    ..The absence of the ER retrieval dilysine motif in EFV Env is likely responsible for this unexpected sorting pathway...
  19. ncbi Non-primate foamy viruses
    A Saib
    CNRS UPR9051, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Curr Top Microbiol Immunol 277:197-211. 2003
    ..In their hosts, PFVs seem to be apathogenic, mirroring an efficient control of virus replication in vivo. Comparing the biology of the different virus isolates will certainly help to unravel the biology of these retroviruses...
  20. pmc Isolation of an active Lv1 gene from cattle indicates that tripartite motif protein-mediated innate immunity to retroviral infection is widespread among mammals
    Laura M J Ylinen
    Department of Infection, Royal Free and University College Medical School, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom
    J Virol 80:7332-8. 2006
    ..The data support the conclusion that TRIM protein-mediated restriction of retroviral infection is a more common attribute of mammals than previously appreciated...
  21. ncbi XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH
    Rebecca S Arnold
    Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Urology 75:755-61. 2010
    ....
  22. pmc The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3
    Marc Andre Langlois
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom CB2 0QH
    J Virol 83:11550-9. 2009
    ....
  23. pmc Transspecies transmission of the endogenous koala retrovirus
    Uwe Fiebig
    Robert Koch Institute, Nordufer 20, D 13353 Berlin, Germany
    J Virol 80:5651-4. 2006
    ..Finally, evidence for immunosuppressive properties of the KoRV was obtained...
  24. ncbi Macroevolution of complex retroviruses
    Aris Katzourakis
    Zoology Department, University of Oxford, Oxford OX1 3PS, UK
    Science 325:1512. 2009
    ....
  25. pmc Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H
    Molly OhAinle
    Molecular and Cellular Biology Program, University of Washington, Seattle 98109, USA
    J Virol 80:3853-62. 2006
    ..The consequences of the lack of antiviral activity of human APOBEC3H are likely to be relevant to the current-day abilities of humans to combat retroviral challenges...
  26. ncbi Foamy virus infection in primates
    S M Murray
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Med Primatol 35:225-35. 2006
    ..As most primates in HIV/SIV research are coinfected with FV, investigation into possible interactions between these viruses is of interest. The use of FV as a vector for gene therapy is also discussed...
  27. pmc Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection
    Mario L Santiago
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Science 321:1343-6. 2008
    ..The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections...
  28. pmc In vitro characterization of a koala retrovirus
    Nidia M Oliveira
    Section on Molecular Virology, National Institute of Mental Health, NIH, 49 Convent Drive, MSC 4483, Bethesda, Maryland 20892 4483, USA
    J Virol 80:3104-7. 2006
    ..KoRV represents a unique example of a gammaretrovirus whose envelope has evolved to allow for its expanded host range and zoonotic potential...
  29. pmc Heparan sulfate is an attachment factor for foamy virus entry
    Kathrin Plochmann
    University of Wurzburg, Institute of Virology and Immunobiology, Wurzburg, Germany
    J Virol 86:10028-35. 2012
    ..Both PFV and FFV infection were inhibited by soluble heparin. Our results show that FVs bind to HS and that this interaction is a pivotal step for viral entry, suggesting that HS is a cellular attachment factor for FVs...
  30. ncbi Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction
    Sarah Chareza
    German Cancer Research Center DKFZ, Research Program Infection and Cancer, Heidelberg, Germany
    Virology 424:138-46. 2012
    ..Additionally, one-domain feA3 proteins can homo- and hetero-dimerize in vitro, but a trans-dominant phenotype of any of the low-activity feA3 forms on FFV restriction by one of the highly-active feA3Z2 proteins was not detectable...
  31. ncbi The replication strategy of foamy viruses
    A Rethwilm
    Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, Dresden, 01307 Germany
    Curr Top Microbiol Immunol 277:1-26. 2003
    ..A number of experimental findings in favour of the view that foamy viruses are reverse transcribing DNA viruses which integrate into the host cell genome are discussed...
  32. ncbi Identification of a human population infected with simian foamy viruses
    W Heneine
    HIV and Retrovirology Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Nat Med 4:403-7. 1998
    ..The infecting SFV originated from an African green monkey (one person) and baboons (three people). These infections have not as yet resulted in either disease or sexual transmission, and may represent benign endpoint infections...
  33. ncbi Why aren't foamy viruses pathogenic?
    M Linial
    Divn of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA 98019, USA
    Trends Microbiol 8:284-9. 2000
    ..Factors that could contribute to these benign persistent infections include regulated transcription from the two viral promoters, the functions of the Bet accessory protein and the host immune response...
  34. ncbi Murine endogenous retroviruses
    C Stocking
    Heinrich Pette Institute, Hamburg, Germany
    Cell Mol Life Sci 65:3383-98. 2008
    ..We review mechanisms by which an adaptive coexistence has evolved. (Part of a multi-author review)...
  35. pmc Alteration of blood-brain barrier integrity by retroviral infection
    Philippe V Afonso
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA3015, Institut Pasteur, Paris, France
    PLoS Pathog 4:e1000205. 2008
    ....
  36. pmc Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection
    M Iwashiro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 98:9226-30. 2001
    ..These results suggest a possible explanation for HIV- and human T cell leukemia virus-I-induced immunosuppression in the absence of T cell depletion...
  37. pmc Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques
    Gregory Q Del Prete
    AIDS and Cancer Virus Program, National Cancer Institute, Frederick, Maryland, USA
    J Virol 86:3152-66. 2012
    ..Given that human APOBEC proteins restrict XMRV infection in vitro, human XMRV infection, if it occurred, would be expected to be characterized by similarly limited viral replication and spread...
  38. ncbi Simian foamy virus infection in humans: prevalence and management
    Arifa S Khan
    Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Expert Rev Anti Infect Ther 7:569-80. 2009
    ..These steps will help prevent the emergence of a novel pathogen and reduce the risk of transmission of another potential pathogenic human retrovirus...
  39. pmc Characterization, mapping, and distribution of the two XMRV parental proviruses
    Oya Cingoz
    Department of Molecular Biology and Microbiology, Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    J Virol 86:328-38. 2012
    ....
  40. pmc Frequent and recent human acquisition of simian foamy viruses through apes' bites in central Africa
    Edouard Betsem
    Unit of Epidemiology and Pathophysiology of Oncogenic Viruses, Department of Virology, Institut Pasteur, Paris, France
    PLoS Pathog 7:e1002306. 2011
    ..The virus was found to persist over several years, with low SFV loads in infected persons. Secondary transmission remains an open question...
  41. pmc A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences
    William Lowther
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Virol 79:10093-6. 2005
    ..Reverse transcriptase PCR results demonstrated that each of the viral insertions led to elevated expression of the presumed target flanking genes...
  42. pmc Multiple sources of contamination in samples from patients reported to have XMRV infection
    Mary F Kearney
    HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS ONE 7:e30889. 2012
    ....
  43. ncbi Porcine endogenous retroviruses and xenotransplantation
    C A Wilson
    Division of Cellular and Gene Therapies, Gene Transfer and Immunogenicity Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Cell Mol Life Sci 65:3399-412. 2008
    ..However, in spite of the past 10 years of investigation, the actual risk for PERV infection, replication, and pathogenic outcome in human recipients of xenotransplantation products is still undefined. (Part of a multi-author review)...
  44. pmc Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression
    S M Murray
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Virol 80:663-70. 2006
    ....
  45. pmc Retroviral proteins that interact with the host cell cytoskeleton
    Mojgan H Naghavi
    School of Medicine and Medical Science, Center for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
    Curr Opin Immunol 19:402-7. 2007
    ..Developing studies are discovering several host and viral factors that play important roles in retroviral trafficking...
  46. ncbi Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein
    Virginie Sandrin
    INSERM U412, Lyon Ecole Normale Supérieure de Lyon, and IFR128 BioSciences Lyon Gerland, Lyon, F 69007 France
    J Biol Chem 281:528-42. 2006
    ..Finally, the expression of Nef proteins specifically enhanced the incorporation of the retroviral GPs by increasing their localization in late endosomes...
  47. pmc Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor
    Mario L Santiago
    Division of Infectious Diseases, University of Colorado Denver, Mail Stop B 168, 12700 E 19th Avenue, Aurora, CO 80045, USA
    J Virol 85:189-99. 2011
    ..Overall, these findings argue against the generality of BAFF-R polymorphisms as a dominant mechanism to explain the Rfv3 recovery phenotype and further strengthen the evidence that Apobec3 encodes Rfv3...
  48. pmc High prevalence, coinfection rate, and genetic diversity of retroviruses in wild red colobus monkeys (Piliocolobus badius badius) in Tai National Park, Cote d'Ivoire
    Siv Aina J Leendertz
    Research Group Emerging Zoonoses, Robert Koch Institut, Nordufer 20, Berlin, Germany
    J Virol 84:7427-36. 2010
    ..The high prevalence of all three retroviral infections in P. b. badius represents a source of infection to chimpanzees and possibly to humans, who hunt them...
  49. ncbi Biology and evolution of the endogenous koala retrovirus
    R Tarlinton
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, United Kingdom
    Cell Mol Life Sci 65:3413-21. 2008
    ..Part of a multi-author review)...
  50. pmc Interspecies transmission of simian foamy virus in a natural predator-prey system
    Fabian H Leendertz
    Emerging Zoonoses, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 82:7741-4. 2008
    ..Chimpanzees infected with chimpanzee SFV strains were shown to be coinfected with SFV from colobus monkeys, indicating that apes are susceptible to SFV superinfection, including highly divergent strains from other primate species...
  51. pmc The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3
    Angelo Kolokithas
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    J Virol 84:10933-6. 2010
    ..Furthermore, a gGag-deficient virus restricted for replication in wild-type mice replicates efficiently in APOBEC3 knockout mice, implying a novel role of gGag in circumventing the action of APOBEC3 in vivo...
  52. ncbi Multiple retroviral infection by HTLV type 1, 2, 3 and simian foamy virus in a family of Pygmies from Cameroon
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, URA CNRS 3015, Departement de Virologie, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    Virology 410:48-55. 2011
    ....
  53. pmc Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    PLoS ONE 6:e16609. 2011
    ..Recently, the xenotropic murine leukemia virus-related virus (XMRV) has been implicated in chronic fatigue syndrome (CFS) and in prostate cancer by several, though not all studies...
  54. ncbi Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 309:248-57. 2003
    ..These results demonstrate the ability of the CA-WB assay to detect infection in a large number of NHP species, including previously uncharacterized infections with divergent SFVs...
  55. pmc Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:10774-9. 2004
    ..These data indicate that TRIM5alpha can confer broad innate immunity to retrovirus infection in primate cells and is likely to be an important natural barrier to cross-species retrovirus transmission...
  56. ncbi Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection
    Gennadiy Zelinskyy
    Institut fuer Virologie des Universitaetsklinikums Essen, Essen, Germany
    Eur J Immunol 36:2658-70. 2006
    ..Transfer as well as depletion experiments indicated that regulatory CD4+ cells developed during the second week of FV infection and subsequently suppressed CD8+ T cell functions, which was associated with impaired virus clearance...
  57. pmc Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, Paris, France
    Retrovirology 3:23. 2006
    ....
  58. pmc Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 72:6554-8. 1998
    ..The results indicated that immune mechanisms rather than viral interference mediated protection...
  59. ncbi Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia
    Severine Landais
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Cancer Res 67:5699-707. 2007
    ....
  60. ncbi Immunosuppression by retroviruses: implications for xenotransplantation
    J Denner
    Paul Ehrlich Institut, Langen, Germany
    Ann N Y Acad Sci 862:75-86. 1998
    ....
  61. pmc Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs
    Tobias Paprotka
    Viral Mutation Section, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702 1201, USA
    J Virol 84:5719-29. 2010
    ..Furthermore, the anti-HIV-1 drugs AZT, tenofovir, and raltegravir may be useful for treatment of XMRV infection...
  62. pmc Coinfection of Ugandan red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with novel, divergent delta-, lenti-, and spumaretroviruses
    Tony L Goldberg
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 83:11318-29. 2009
    ....
  63. ncbi Human infection with foamy viruses
    W Heneine
    HIV and Retrovirology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G19, Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 277:181-96. 2003
    ..Additional studies are needed to better define the prevalence and natural history of SFV in humans...
  64. pmc Immunity to retroviral infection: the Friend virus model
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 94:7811-6. 1997
    ..In vivo depletion experiments demonstrate different requirements for CD8(+) T cells depending on the vaccine used. The implications of these studies for human retroviral diseases are discussed...
  65. pmc XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberg
    Department of Pathology and Cell Biology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:16351-6. 2009
    ..Our observations provide evidence for an association of XMRV with malignant cells and with more aggressive tumors...
  66. pmc Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Retrovirology 7:10. 2010
    ....
  67. ncbi Antibodies against Gag are diagnostic markers for feline foamy virus infections while Env and Bet reactivity is undetectable in a substantial fraction of infected cats
    Fabian Romen
    Department of Genome Modifications and Carcinogenesis, Research Program Infection and Cancer, German Cancer Research Center, Germany
    Virology 345:502-8. 2006
    ..With one exception, all Bet- and/or Env-positive sera were also positive for Gag. In this small epidemiological pilot study, FFV antibodies were not significantly associated with clinical disease...
  68. pmc The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus
    Yung Tsun Lo
    Department of Infectious Disease and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    J Virol 84:2832-42. 2010
    ..Furthermore, despite the presence of a nuclear localization signal sequence in Gag, we observed no foamy virus Gag importation into the nucleus in the absence of integrase...
  69. ncbi Simian foamy virus prevalence in Macaca mulatta and zookeepers
    Fen Huang
    Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
    AIDS Res Hum Retroviruses 28:591-3. 2012
    ..6% with each other as well as 90.8-99.5% with M. mulatta. The investigation revealed the high prevalence of the SFV in M. mulatta in China and its zoonotic transmission to humans...
  70. pmc Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Retrovirology 7:105. 2010
    ..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
  71. pmc No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome
    Imke Steffen
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS ONE 6:e27870. 2011
    ..Multiple techniques were employed, including nested and qRT-PCR, cell culture, and immunoblotting. We found no evidence of XMRV or MLV in humans and conclude that CFS is not associated with these gammaretroviruses...
  72. pmc Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice
    Sachiyo Tsuji-Kawahara
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 84:6082-95. 2010
    ....
  73. ncbi Coinfection with HIV-1 and simian foamy virus in West Central Africans
    William M Switzer
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, Sexually Transmitted Diseases, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
    J Infect Dis 197:1389-93. 2008
    ..The findings of the present study suggest opportunities for bloodborne and sexual transmission of SFV and highlight the importance of defining the clinical consequences of dual infections...
  74. pmc Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo
    Mario L Santiago
    Division of Infectious Diseases, University of Colorado Denver, Mail Stop B168, 12700 East 19th Avenue, Aurora, CO 80045, USA
    J Immunol 185:1114-23. 2010
    ..These findings raise the possibility that enabling Apobec3 activity during acute infection with human pathogenic retroviruses, such as HIV-1, may similarly facilitate stronger virus-specific neutralizing Ab responses...
  75. ncbi Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus
    Eva Balada
    Research Unit in Systemic Autoimmune Diseases, Vall d Hebron Research Institute, Vall d Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain
    J Clin Immunol 31:584-7. 2011
    ..Since chronic fatigue is commonly reported in patients with systemic lupus erythematosus (SLE) we aimed at testing the presence of this virus in these patients...
  76. pmc Susceptibility of human primary neuronal cells to xenotropic murine leukemia virus-related (XMRV) virus infection
    Veerasamy Ravichandran
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Virol J 8:443. 2011
    ..In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV...
  77. pmc Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus
    Alice Rusmevichientong
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 85:12830-4. 2011
    ..Our results provide direct evidence for contamination during analysis of XMRV integration sites...
  78. ncbi In vitro suppression of CD8+ T cell function by Friend virus-induced regulatory T cells
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S Fourth Street, Hamilton, MT 59840, USA
    J Immunol 176:3342-9. 2006
    ..Such activity may also have adverse consequences by allowing viruses to establish and maintain chronic infections if suppression of antiviral immune responses occurs before virus eradication...
  79. ncbi Organogenic role of B lymphocytes in mucosal immunity
    T V Golovkina
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Science 286:1965-8. 1999
    ..The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers...
  80. pmc Diverse contexts of zoonotic transmission of simian foamy viruses in Asia
    Lisa Jones-Engel
    Division of International Programs, National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Emerg Infect Dis 14:1200-8. 2008
    ..Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia...
  81. pmc B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection
    Mickaël J Y Ploquin
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 187:3321-30. 2011
    ..Our results suggest that B cell presentation of vaccine Ags could be manipulated to direct the appropriate CD4(+) T cell response...
  82. pmc Vaccination with an adenoviral vector that encodes and displays a retroviral antigen induces improved neutralizing antibody and CD4+ T-cell responses and confers enhanced protection
    Wibke Bayer
    Ruhr University Bochum, Institute of Microbiology and Hygiene, Department of Molecular and Medical Virology, Universitaetsstr 150, Bldg MA, Rm 6 40, D 44801 Bochum, Germany
    J Virol 84:1967-76. 2010
    ..This new type of adenovirus-based vaccine could be a valuable tool for vaccination...
  83. pmc Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha
    Michel J Perron
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 80:5631-6. 2006
    ..2 domain. Acidic residues in v3 complement basic residue 110 of the N-MLV capsid. The results support recognition of the retroviral capsid by the TRIM5alpha B30.2 domain...
  84. ncbi The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
    D Gallahan
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Oncogene 14:1883-90. 1997
    ....
  85. ncbi Feline leukaemia virus (FeLV) and feline immunodeficiency virus infections in cats in the Pisa district of Tuscany, and attempts to control FeLV infection in a colony of domestic cats by vaccination
    P Bandecchi
    Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Universita di Pisa, Viale delle Piagge 2, 56100 Pisa, Italy
    Vet Rec 158:555-7. 2006
    ....
  86. pmc Early events in retrovirus XMRV infection of the wild-derived mouse Mus pahari
    Toshie Sakuma
    Department of Molecular Medicine, Mayo Clinic, Guggenheim 18 11c, 200 First Street, SW, Rochester, MN 55905, USA
    J Virol 85:1205-13. 2011
    ..These data support the use of Mus pahari as a model for XMRV pathogenesis and as a platform for vaccine and drug development against this potential human pathogen...
  87. pmc Effects of type I interferons on Friend retrovirus infection
    Nicole Gerlach
    Institut für Virologie des Universitätsklinikum Essen, Universitat Duisburg Essen, 45122 Essen, Germany
    J Virol 80:3438-44. 2006
    ..These findings indicate that type I IFN plays an important role in the immediate antiviral defense against Friend retrovirus infection...
  88. pmc Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection
    Ronald J Messer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:12260-5. 2004
    ..These results emphasize the importance of inducing both T cell responses and virus-neutralizing antibody responses for effective retroviral vaccine protection...
  89. pmc Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus
    Sanggu Kim
    Biomedical Engineering Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10255. 2010
    ..We conclude that integration of XMRV DNA involves a coordinated joining of two viral DNA ends that are spaced 4 bp apart on the target DNA and proceeds with high fidelity...
  90. pmc The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates
    Byeongwoon Song
    Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 79:6111-21. 2005
    ..The results are consistent with a role for TRIM5alpha in innate immunity against retroviruses...
  91. ncbi The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein
    J L Portis
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Virology 226:384-92. 1996
    ..These results indicate that glycosylated gag facilitates virus spread within the spleen and to extra-splenic sites, such as the CNS, and suggest that the protein may function through its interaction with the host...
  92. pmc Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 79:8969-78. 2005
    ..However, localization in large cytoplasmic bodies is not required for inhibition of N-MLV by huTRIM5alpha or for inhibition of HIV-1 by chimeric or rhTRIM5alpha...
  93. pmc Unique long terminal repeat and surface glycoprotein gene sequences of feline leukemia virus as determinants of disease outcome
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave SL 38, New Orleans, LA 70112, USA
    J Virol 79:5278-87. 2005
    ..Since the TM genes of FeLV-945 and FeLV-A/61E are nearly identical but the SU genes differ significantly, FeLV-945 SU is implicated in the outcome. These findings identify the FeLV-945 LTR and SU gene as determinants of disease...
  94. pmc Subtle mutational changes in the SU protein of a natural feline leukemia virus subgroup A isolate alter disease spectrum
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave SL 38, New Orleans, LA 70112, USA
    J Virol 79:1351-60. 2005
    ....
  95. ncbi Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells
    Sandra Balkow
    Department of Dermatology, University of Muenster, Muenster, Germany
    Blood 110:3949-58. 2007
    ..Thus, retroviral infection of DCs leads to an expansion of regulatory T cells, which might serve as an immune escape mechanism of the virus...
  96. pmc Efficient mother-to-child transfer of antiretroviral immunity in the context of preclinical monoclonal antibody-based immunotherapy
    Laurent Gros
    Institut de Genetique Moleculaire de Montpellier, UMR 5535 IFR 122, CNRS, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Virol 80:10191-200. 2006
    ....
  97. pmc Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients
    Oliver Hohn
    Robert Koch Institute, Centre for Biological Safety 4, Nordufer 20, 13353 Berlin, Germany
    Retrovirology 6:92. 2009
    ..Here, we attempt to measure the prevalence of XMRV in prostate cancer cases in Germany and determine whether an analogous association with the R462Q polymorphism exists...
  98. ncbi Association between endogenous feline leukemia virus loads and exogenous feline leukemia virus infection in domestic cats
    Ravi Tandon
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    Virus Res 135:136-43. 2008
    ..In conclusion, our results demonstrated an association between enFeLV loads and FeLV replication but not outcome of infection. enFeLV should be considered as an important confounder in experimental FeLV infection or vaccination studies...
  99. ncbi No in vivo infection of triple immunosuppressed non-human primates after inoculation with high titers of porcine endogenous retroviruses
    Volker Specke
    Robert Koch Institute, Berlin, Germany
    Xenotransplantation 16:34-44. 2009
    ..Absence of PERV transmission has been shown in first experimental and clinical xenotransplantations; however, these trials suffered from the absence of long-term exposure (transplant survival) and profound immunosuppression...
  100. pmc Feline leukemia virus and other pathogens as important threats to the survival of the critically endangered Iberian lynx (Lynx pardinus)
    Marina L Meli
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e4744. 2009
    ..In this context, a retrospective survey on prevalence of selected feline pathogens in free-ranging lynxes was initiated...
  101. pmc Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer
    Seunghee Hong
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Virol 83:6995-7003. 2009
    ....

Research Grants55

  1. MARROW TRANSPLANT THERAPY FOR RETROVIRUS INFECTIONS
    PETER GASPER; Fiscal Year: 1992
    ..Additional studies include interleukin 2 stimulation and expansion of immune donor lymphocytes and antiviral chemotherapeutic treatment of donor cats prior to transplanting their cell into persistently infected recipients...
  2. HIV & HTLV-I COHORT STUDIES OF HAITIAN WOMEN AND INFANTS
    Neal Halsey; Fiscal Year: 1991
    ..I infections in a high risk developing country population. The quantitative data will assist health care providers to develop strategies for the control of HIV and HTLV-I in this and similar populations throughout the world...
  3. RETROVIRUS-HOST INTERACTIONS
    Harriet Robinson; Fiscal Year: 1992
    ....
  4. Feline Leukemia Virus Infection: A Model of Effective Retroviral Immunity
    Andrea Torres; Fiscal Year: 2007
    ..The results of these studies should provide insight into the early effective vs. ineffective host control of retrovirus infections. ..
  5. HPV and HTLV Infection in Female Sex Workers in Peru
    Joseph Zunt; Fiscal Year: 2009
    ..abstract_text> ..
  6. NONHUMAN PRIMATE AIDS SYMPOSIUM
    PETER GERONE; Fiscal Year: 1990
    ..The individuals presenting papers will be asked to submit manuscripts which will be published as proceedings of the conference in the Journal of Medical Primatology...
  7. NONHUMAN PRIMATE MODELS FOR AIDS SYMPOSIUM
    William Morton; Fiscal Year: 1991
    ..The attendance has grown with each subsequent annual symposium. It is internationally recognized as the most significant annual meeting on this subject...
  8. 10TH ANNL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AID
    Matthew Kessler; Fiscal Year: 1992
    ..Approximately 300 researchers and primate veterinarians from at least ten countries are expected to attend the symposium in San Juan...
  9. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
    ..The results of these studies will enhance our understanding of the role of apoptosis in the development of neoplastic disease. ..
  10. Determinants of Natural Host Resistance to SIV agm
    Jonathan Allan; Fiscal Year: 2005
    ..In summary, this proposal seeks to understand the role of coreceptor expression, viral replication and cellular immunity in the pathogenesis of SIV. ..
  11. Inhibition of HIV by Novel Chimeric Receptors
    Jonathan Allan; Fiscal Year: 2004
    ..If successful, this strategy will have broad applications in immunotherapy and immune reconstitution against HIV-1. ..
  12. MOLECULAR BIOLOGY OF JAAGSIEKTE SHEEP RETROVIRUS
    Hung Fan; Fiscal Year: 2003
    ..These experiments will provide insight into JSRV-induced lung cancer in sheep, and possibly into human BAC. ..
  13. MICROGLIA IN RETROVIRUS INDUCED NEURODEGENERATION
    William Lynch; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  15. EXPRESSION AND PATHOGENESIS OF MURINE LEUKEMIA VIRUS
    Hung Fan; Fiscal Year: 2005
    ..low expression. Together, these experiments will provide new and important insights into leukemogenesis by MuLVs. ..
  16. T cell loss in a murine model for AIDS
    VIRGINIA SCOFIELD; Fiscal Year: 2006
    ..Studies of Galavit as an anti-HIV antiviral agent, or as an antioxidant therapy for prevention of HIV cytopathic effects, are the subject of another application in preparation. ..
  17. mTOR Signaling In Chronic Myelogenous Leukemia
    Hung Fan; Fiscal Year: 2009
    ..abstract_text> ..
  18. CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTS
    Stephen Goff; Fiscal Year: 2003
    ..In each case, these tests will be applied to existing panels of mutants to help localize the regions needed for these activities. ..
  19. Role of cytokines in retroviral neuropathogenesis
    Karin Peterson; Fiscal Year: 2005
    ..Therefore, we will also analyze how infected microglia cells regulate TNF alpha and MCP-1production, in vivo. ..
  20. Primate enteroviruses transmission in Bangladesh
    Lisa Jones Engel; Fiscal Year: 2007
    ..Ultimately, this data will provide insight into the potential emergence of NHP-borne pathogens and help to deter the spread of emerging zoonotic threats. [unreadable] [unreadable]..
  21. Role of ITAM repeats in virus-induced breast cancer
    Susan R Ross; Fiscal Year: 2010
    ..These studies are of potential importance in developing new treatment paradigms for breast and other cancers, especially those associated with viruses that encode proteins that activate ITAM-mediated signaling. ..
  22. Translational Control of Retroviral Unspliced mRNA
    KATHLEEN A BORIS LAWRIE; Fiscal Year: 2010
    ..abstract_text> ..
  23. GRADUATE AND POSTDOCTORAL TRAINING IN VIRAL ONCOLOGY
    Maxine Linial; Fiscal Year: 2007
    ..The goal of this program is to train researchers who are highly skilled in both the intellectual and technical aspects of research in basic laboratory approaches to virology and oncology. [unreadable] [unreadable]..
  24. Mechanisms of Inactivation of T Cells by HSV
    KEITH JEROME; Fiscal Year: 2006
    ..The elucidaton of the mechanism by which HSV inactivates T cells will provide new insight into the regulation of T cells, and may suggest targets for pharmacologic manipulation. [unreadable] [unreadable] [unreadable]..
  25. Mechanisms of AID-dependent Adaptive and Innate Immunity
    Reuben S Harris; Fiscal Year: 2010
    ..abstract_text> ..
  26. Role of RNase L in the Biology of Prostate Cancer
    Robert Silverman; Fiscal Year: 2008
    ..The experiments described in this PROPOSAL describe a previously unexplored area of research that may bring us closer to the eventual goal of understanding a molecular basis for prostate cancer. ..
  27. LENTIVIRAL VARIATION AND AIDS
    Julie Overbaugh; Fiscal Year: 2008
    ..Collectively these studies will define the interplay between the properties of the infecting virus, the immune response and replication fitness in SIV/HIV pathogenesis. ..
  28. CYTOKINE SIGNAL TRANSDUCTION IN RETINAL DEVELOPMENT
    Xian Jie Yang; Fiscal Year: 2008
    ..These proposed studies will advance our understanding of cytokine signaling mechanisms in the normal developing retina and in a mutant model of photoreceptor degeneration. ..
  29. HIV Infection of Non-Dividing Cells
    Michael Emerman; Fiscal Year: 2010
    ..The identification of the precise viral determinants that allow it access to non-dividing cells may present new drug targets against HIV. ..
  30. Retrovirus Restriction by Trima5alpha
    Paul Bieniasz; Fiscal Year: 2009
    ....
  31. Actions of Vif and APOBEC3 proteins in HIV-1 Replication
    Yong Hui Zheng; Fiscal Year: 2010
    ..Such findings may provide a more effective modality for the treatment of HIV infection to be used in conjunction with other chemotherapy and vaccines. ..
  32. Molecular Therapy Core Centers
    Arthur Miller; Fiscal Year: 2008
    ..abstract_text> ..
  33. 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPY
    Robert Cardiff; Fiscal Year: 2006
    ..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  34. Inhibition of CTL killing by HSV
    KEITH JEROME; Fiscal Year: 2005
    ....
  35. Myosin VIIa Gene Therapy
    Xian Jie Yang; Fiscal Year: 2005
    ..abstract_text> ..
  36. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  37. FOAMY VIRUS INFECTION IN VITRO AND IN VIVO
    Maxine Linial; Fiscal Year: 2005
    ..These experiments will be will be important for the assessment of the utility of foamy viruses as vectors for gene therapy. ..
  38. REGULATION OF FELV REPLICATION AND PATHOGENESIS
    Julie Overbaugh; Fiscal Year: 2004
    ..In this regard, it is striking that in both FeLV and HIV infection, there is selection for T-cell tropic, cytopathic variants in the host, despite the many differences between these viruses. ..
  39. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    ....
  40. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  41. PREVENTION OF HIV SHEDDING IN WOMEN--TRIAL OF VITAMIN A
    Julie Overbaugh; Fiscal Year: 2003
    ..If this preliminary result is confirmed in a full-scale clinical trial, vitamin A supplementation may offer a simple inexpensive intervention to decrease heterosexual and vertical transmission of HIV-1 in the developing world. ..
  42. Institute of Human Virology Annual Meeting 2002-2004
    Robert Gallo; Fiscal Year: 2002
    ..abstract_text> ..
  43. RETROVIRAL ETIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    Andrew Mason; Fiscal Year: 2002
    ....
  44. A mutable vaccine for biodefense
    Marilia Cascalho; Fiscal Year: 2005
    ..The vaccine will then be tested for ability to promote an immune response against antigenic variants of influenza. ..
  45. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  46. Retroviral interactions with toll-like receptors
    Susan Ross; Fiscal Year: 2006
    ..The work proposed here represents the first characterization of viral PAMPs as well as the first structural studies of the extracellular domains of TLR2 and TLR4. ..
  47. Genetics of Susceptibility to MMTV-Induced Mammary Tumor
    Susan Ross; Fiscal Year: 2006
    ..The results obtained from these studies will greatly increase our understanding of the genetic mechanisms which viruses use to infect their hosts and how genetic resistance to such viruses in the hosts occurs. ..
  48. Characterization of the MMTV Receptor
    Susan Ross; Fiscal Year: 2006
    ..Together, these two approaches will allow us to better understand how viruses utilize the biology of their host for propagation and how MMTV specifically induces breast cancer in mice. ..
  49. Inactivation of CTL by HSV-infected cells
    KEITH JEROME; Fiscal Year: 2005
    ..The understanding of this pathway may also suggest rational targets for pharmacological manipulation of CTL function. ..
  50. Role of Phospholipid Scramblase in Interferon Action
    Robert Silverman; Fiscal Year: 2005
    ..abstract_text> ..
  51. Pathobiology of SAIDS-Associated Lymphomas
    Laura Levy; Fiscal Year: 2006
    ..A clear understanding of the mechanisms by which these cytokines effect positive and negative growth regulation of 1) lymphoma cells could contribute to the development of therapeutic agents that modulate their action. ..
  52. Accessory roles of Tat in HIV-1 replication
    Michael Emerman; Fiscal Year: 2005
    ..Thus, the overall goal of this proposal is to identify functions attributable to the second exon of Tat and to ascertain the role of these Tat functions in HIV-1 replication and pathogenesis. ..