coxsackievirus infections

Summary

Summary: A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.

Top Publications

  1. pmc Coxsackievirus A6 and hand, foot, and mouth disease, Finland
    Riikka Osterback
    University of Turku, Turku, Finland
    Emerg Infect Dis 15:1485-8. 2009
  2. ncbi Molecular biology and pathogenesis of viral myocarditis
    Mitra Esfandiarei
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Providence Health Care Research Institute, Vancouver, Canada
    Annu Rev Pathol 3:127-55. 2008
  3. ncbi Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009
    Shih Hsuan Lo
    Department of Pediatrics, Children s Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Microbiol Immunol Infect 44:252-7. 2011
  4. pmc Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period
    Ralph Feuer
    Department of Immunology and Microbial Science, La Jolla, California 92037, USA
    J Virol 83:9356-69. 2009
  5. ncbi Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005
  6. ncbi Molecular diagnosis and clinical presentations of enteroviral infections in Taipei during the 2008 epidemic
    Min Hsiung Lee
    Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 44:178-83. 2011
  7. ncbi Coxsackievirus B3-associated aseptic meningitis: an emerging infection in Hong Kong
    Ann H Wong
    Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong SAR, China
    J Med Virol 83:483-9. 2011
  8. ncbi Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells
    Kun Lv
    Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    Clin Immunol 140:92-101. 2011
  9. ncbi Acute haemorrhagic conjunctivitis: seroepidemiology of coxsackievirus A24 variant and enterovirus 70 in Singapore
    K T Goh
    Quarantine and Epidemiology Department, Ministry of the Environment, Singapore
    J Med Virol 31:245-7. 1990
  10. pmc Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease
    Ralph Feuer
    Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 163:1379-93. 2003

Research Grants

  1. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
  2. DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    Michael Irwin; Fiscal Year: 2003
  3. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
  4. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
  5. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
  6. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
  7. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
  8. Nutrition, Viral Mutation and Host Defense
    Melinda Beck; Fiscal Year: 2007
  9. The Influence of Nutrition on Influenza Virus Infection
    Melinda Beck; Fiscal Year: 2004
  10. Enterovirus persistence in myocarditis
    Nora Chapman; Fiscal Year: 2003

Detail Information

Publications210 found, 100 shown here

  1. pmc Coxsackievirus A6 and hand, foot, and mouth disease, Finland
    Riikka Osterback
    University of Turku, Turku, Finland
    Emerg Infect Dis 15:1485-8. 2009
    ..We identified an unusual enterovirus type, coxsackievirus A6 (CVA6), as the causative agent. CVA6 infections may be emerging as a new and major cause of epidemic HFMD...
  2. ncbi Molecular biology and pathogenesis of viral myocarditis
    Mitra Esfandiarei
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Providence Health Care Research Institute, Vancouver, Canada
    Annu Rev Pathol 3:127-55. 2008
    ..Advances in genomics and proteomics, and in the use of informatics and biostatistics, are allowing unbiased initial evaluations that can be the basis for testable hypotheses about virus pathogenesis and new therapies...
  3. ncbi Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009
    Shih Hsuan Lo
    Department of Pediatrics, Children s Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Microbiol Immunol Infect 44:252-7. 2011
    ..This study is to define clinical manifestations and laboratory findings of Cox A6 infection in children...
  4. pmc Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period
    Ralph Feuer
    Department of Immunology and Microbial Science, La Jolla, California 92037, USA
    J Virol 83:9356-69. 2009
    ..Thus, the effects of a relatively common infection during the neonatal period may be long lasting, and the prognosis for newborn infants recovering from acute infection should be reexplored...
  5. ncbi Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005
    ..Beta-adrenergic receptor stimulation influences the production of cytokines heralding the possibility of modulating cytokine production by beta-adrenergic blockers...
  6. ncbi Molecular diagnosis and clinical presentations of enteroviral infections in Taipei during the 2008 epidemic
    Min Hsiung Lee
    Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 44:178-83. 2011
    ..To establish an early detection and effective management for children with EV71 infection, sensitive molecular diagnostic methods were applied from May to July 2008...
  7. ncbi Coxsackievirus B3-associated aseptic meningitis: an emerging infection in Hong Kong
    Ann H Wong
    Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong SAR, China
    J Med Virol 83:483-9. 2011
    ....
  8. ncbi Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells
    Kun Lv
    Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    Clin Immunol 140:92-101. 2011
    ..Galectin-9 was further found to promote the proliferation of regulatory T cells and elevated IL-4-secreting Th2 cells. It may represent as a novel therapeutic strategy in treating Th1-mediated inflammatory cardiac disease...
  9. ncbi Acute haemorrhagic conjunctivitis: seroepidemiology of coxsackievirus A24 variant and enterovirus 70 in Singapore
    K T Goh
    Quarantine and Epidemiology Department, Ministry of the Environment, Singapore
    J Med Virol 31:245-7. 1990
    ..It appears from the data that an epidemic could be triggered when the herd immunity of the population falls below a critical level. There was a significant correlation in seroprevalence between CA24v and EV70 (P = 7.75 x 10(-3)...
  10. pmc Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease
    Ralph Feuer
    Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 163:1379-93. 2003
    Neonates are particularly susceptible to coxsackievirus infections of the central nervous system (CNS), which can cause meningitis, encephalitis, and long-term neurological deficits...
  11. pmc MDA5 and MAVS mediate type I interferon responses to coxsackie B virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Virol 84:254-60. 2010
    ..These data highlight the importance of type I interferon in host defense and provide insight on the mechanisms of innate immune responses following coxsackievirus infection...
  12. pmc Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity
    Delisa Fairweather
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Methods 41:118-22. 2007
    ..An improved understanding of the interaction between environmental exposures and the development of heart disease represents a clear challenge for immunotoxicologists...
  13. pmc A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy
    Carlos Gorbea
    Department of Pediatrics Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:23208-23. 2010
    ..These data suggest that individuals harboring these variants may have a blunted innate immune response to enteroviral infection, leading to reduced viral clearance and an increased risk of cardiac pathology...
  14. ncbi Pathogenesis of myocarditis and dilated cardiomyopathy
    Daniela Cihakova
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Immunol 99:95-114. 2008
    ..The most abundant cells in heart infiltrate in human giant cell myocarditis or EAM are monocyte/macrophages, and there is now evidence that macrophages play a decisive role in the course of EAM...
  15. ncbi Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus-induced myocarditis
    Delisa Fairweather
    The Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Rev Med Virol 15:17-27. 2005
    ..Recent findings suggest that mast cell activation by viruses or adjuvants may be important in initiating autoimmune disease...
  16. ncbi CXCL10 inhibits viral replication through recruitment of natural killer cells in coxsackievirus B3-induced myocarditis
    Ji Yuan
    Department of Pathology and Laboratory Medicine, The iCAPTURE Center, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Circ Res 104:628-38. 2009
    ..Nonetheless, CXCL10-directed chemoattractant effect is not sufficient for host to clear the virus in the heart...
  17. ncbi Molecular epidemiology of coxsackie A type 24 variant in Taiwan, 2000-2007
    Pei Yu Chu
    Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Clin Virol 45:285-91. 2009
    ..Epidemics of acute hemorrhagic conjunctivitis (AHC) caused by a coxsackievirus A24 variant (CA24v) appeared in Taiwan in 2000-2002 and again in 2006-2007...
  18. ncbi Acute hemorrhagic conjunctivitis
    P W Wright
    University of Texas Health Center, Tyler
    Am Fam Physician 45:173-8. 1992
    ..Information about acute hemorrhagic conjunctivitis should be provided to patients and the community in order to prevent undue alarm, discourage home remedies and control the spread of this highly contagious disease...
  19. ncbi Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis
    Kang Li
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    Circ Res 105:353-64. 2009
    ..Interestingly, comparable macrophage numbers were observed in the myocardium of female mice during acute myocarditis...
  20. ncbi Comparison of clinical features between coxsackievirus A2 and enterovirus 71 during the enterovirus outbreak in Taiwan, 2008: a children's hospital experience
    Shih Perng Chen
    Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children s Medical Center, Taoyuan, Taiwan
    J Microbiol Immunol Infect 43:99-104. 2010
    ..In this study, we compared Cox A2 with enterovirus 71 (EV71) in terms of clinical manifestation and epidemiology during the 2008 enterovirus outbreak in Taiwan...
  21. ncbi An outbreak of coxsackievirus A16 infection: comparison with other enteroviruses in a preschool in Taipei
    Pei Chieh Wu
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan South Road, Taipei, Taiwan
    J Microbiol Immunol Infect 43:271-7. 2010
    ..The transmission rate of enteroviruses in young children remains unclear. Therefore, we carried out active surveillance in preschool children to investigate the transmission rate and clinical manifestation of enteroviruses...
  22. ncbi Molecular epidemiology and evolution of coxsackievirus A9
    J Santti
    MediCity Research Laboratory and Department of Virology, University of Turku, Finland
    J Gen Virol 81:1361-72. 2000
    ..Analysis of the deduced amino acid sequences of the VP1 polypeptide demonstrated that the RGD (arginine-glycine-aspartic acid) motif, implicated in the interaction of the virus with integrin, was fully conserved among the isolates...
  23. ncbi Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 85:432-40. 2000
    ..Coxsackie B viruses cause functional impairment and beta-cell death characterized by nuclear pyknosis. Apoptosis appears to play a minor role during a productive CBV infection in beta-cells...
  24. pmc Rapid and highly sensitive coxsackievirus a indirect immunofluorescence assay typing kit for enterovirus serotyping
    Tsuey Li Lin
    Center for Research and Diagnostic, Centers for Disease Control, Department of Health, Taiwan, 161 Kunyang Street, Nan Kang, Taipei, Taiwan
    J Clin Microbiol 46:785-8. 2008
    ..This IFA kit was determined to have 95.9 to 100% sensitivity and 95.8 to 97.2% specificity. It also proved to be beneficial in reducing the number of enteroviruses that are untypeable in the clinical virology laboratory...
  25. pmc Sialic acid is a cellular receptor for coxsackievirus A24 variant, an emerging virus with pandemic potential
    Emma C Nilsson
    Department of Clinical Microbiology, Division of Virology, Umea University, Umeå SE 901 85, Sweden
    J Virol 82:3061-8. 2008
    ..Since several unrelated viruses with tropism for the eye use this receptor, sialic acid-based antiviral drugs that prevent virus entry may be useful for topical treatment of such infections...
  26. pmc Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
    Francesco Dotta
    Department of Internal Medicine, Endocrine and Metabolic Sciences, and Biochemistry, University of Siena, 53100 Siena, Italy
    Proc Natl Acad Sci U S A 104:5115-20. 2007
    ..These studies provide direct evidence that enterovirus can infect beta cells in patients with type 1 diabetes and that infection is associated with inflammation and functional impairment...
  27. pmc Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3
    S A Huber
    Department of Pathology, University of Vermont, Burlington 05405
    J Virol 68:5126-32. 1994
    ..Treatment of the female donors with monoclonal antibodies to either CD3, CD4, or IL-4 molecules abrogates suppression...
  28. ncbi Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent
    Kathy Triantafilou
    Infection and Immunity Group, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Cell Microbiol 7:1117-26. 2005
    ..Here we report that the CBV-induced inflammatory response is mediated through TLR8 and to a lesser extent through TLR7...
  29. pmc A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3
    K U Knowlton
    Department of Medicine, University of California, San Diego 92103, USA
    J Virol 70:7811-8. 1996
    ..In addition, the data demonstrate that a point mutation in the puff region of VP2 can markedly alter the ability of CVB3 to induce myocarditis in mice and tumor necrosis factor alpha secretion from infected BALB/c monocytes...
  30. ncbi Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-alpha transgenic mice
    Sally A Huber
    Department of Pathology, University of Vermont, Colchester 05446, USA
    Circ Res 99:1109-16. 2006
    ..H3 virus infection induces high levels of systemic TNF-alpha, whereas H310A1 virus does not. The low TNF-alpha response during H310A1 infections is likely responsible for the T regulatory cell response in these animals...
  31. pmc Activity of pleconaril against enteroviruses
    D C Pevear
    ViroPharma Incorporated, Exton, Pennsylvania 19341, USA
    Antimicrob Agents Chemother 43:2109-15. 1999
    ..Pleconaril represents a promising new drug candidate for potential use in the treatment of human enteroviral infections...
  32. ncbi Coxsackieviruses infection in northern Taiwan--epidemiology and clinical characteristics
    Feng Bin Yen
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 42:38-46. 2009
    The epidemiology of coxsackievirus has rarely been investigated in Taiwan. This study was performed to ascertain the epidemiological and clinical characteristics of coxsackievirus infections in Taiwan.
  33. pmc Sustained nitric oxide synthesis contributes to immunopathology in ongoing myocarditis attributable to interleukin-10 disorders
    Gudrun Szalay
    Dept of Molecular Pathology, Institute for Pathology, University Hospital Tubingen, Liebermeisterstr 8, D 72076 Tubingen, Germany
    Am J Pathol 169:2085-93. 2006
    ..Moreover, lack of regulatory IL-10 leads to uncontrolled iNOS mRNA production, thus contributing to ongoing myocardial injury...
  34. ncbi A phosphorothioate antisense oligodeoxynucleotide specifically inhibits coxsackievirus B3 replication in cardiomyocytes and mouse hearts
    Ji Yuan
    Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre, University of British Columbia St Paul s Hospital, Vancouver, British Columbia, Canada
    Lab Invest 84:703-14. 2004
    ..Taken together, our results demonstrated a great potential for AS-7 to be further developed into an effective treatment towards viral myocarditis as well as other diseases caused by CVB3 infection...
  35. pmc Complete genome sequence of a coxsackievirus A22 strain in Hong Kong reveals a natural intratypic recombination event
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 85:12098-9. 2011
    ..We report the first complete genome sequence of CVA22 with natural intratypic recombination between CVA22 prototype strain Chulman and CVA22 strain ban99-10427, identified in the stool of a patient in Hong Kong...
  36. ncbi The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease
    P Liu
    Heart and Stroke Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Nat Med 6:429-34. 2000
    ..These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3...
  37. pmc Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71
    Yi Wen Lin
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    PLoS ONE 8:e57591. 2013
    ..These results indicate that hSCARB2-transgenic mice are a useful model for assessing anti-EV71 medications and for studying the pathogenesis induced by EV71...
  38. ncbi DNA vaccine-mediated immune responses in Coxsackie virus B3-infected mice
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, D 07745 Jena, Germany
    Antiviral Res 49:49-54. 2001
    ..In summary, our results indicate that the induction of B cell and/or T cell memory in vaccinated mice prior to challenge is responsible for the protection observed...
  39. ncbi Phylogenetic analysis of a coxsackievirus A24 variant: the most recent worldwide pandemic was caused by progenies of a virus prevalent around 1981
    H Ishiko
    Central Virus Diagnostic Laboratory, National Institute of Health, Tokyo, Japan
    Virology 187:748-59. 1992
    ....
  40. pmc An outbreak of aseptic meningitis caused by coxsackievirus A9 in Gansu, the People's Republic of China
    Aili Cui
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Beijing 100050, PR China
    Virol J 7:72. 2010
    ..An outbreak of aseptic meningitis occurred in Tianshui city of Gansu Province, the People's Republic of China, from March to June 2005. A total of 85 patients were clinical confirmed as aseptic meningitis in this outbreak...
  41. ncbi Molecular characterization of enteroviruses detected in Gyeong-Ju and Po-Hang provinces of Korea in 2003
    Eun Ju Jeong
    Department of Microbiology, Konkuk University School of Medicine and Medical Immunology Center, Institute of Biomedical Science and Technology, Seoul, Korea
    Arch Virol 155:1707-12. 2010
    ..The three EV71 strains were characterized as genogroup C4. These results are the first documentation reporting the occurrence of CA10 and EV71 genogroup C4...
  42. ncbi Gene therapy with CCL2 (MCP-1) mutant protects CVB3-induced myocarditis by compromising Th1 polarization
    Yan Yue
    Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, 199 Ren Ai Road, Suzhou 215123, PR China
    Mol Immunol 48:706-13. 2011
    ..Strategy of blocking in vivo CCL2 activity could effectively alleviate the severity of CVB3-induced myocarditis and may present an alternative therapeutic approach against viral myocarditis...
  43. ncbi Treatment of viral myocarditis caused by coxsackievirus B
    Luigi Brunetti
    Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Am J Health Syst Pharm 65:132-7. 2008
    ..The treatment options for viral myocarditis caused by coxsackievirus B are summarized...
  44. ncbi Coxsackievirus-induced myocarditis: new trends in treatment
    Zhen Liu
    Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Expert Rev Anti Infect Ther 3:641-50. 2005
    ..Finally, the progress in cellular cardiomyoplasty for end-stage therapy, in particular the preliminary clinical trials, is also discussed with respect to its potential future application...
  45. ncbi Genetic analysis of recent Taiwanese isolates of a variant of coxsackievirus A24
    K H Lin
    Department of Clinical Laboratory, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    J Med Virol 64:269-74. 2001
    ..The evolutionary rate was re-estimated to be 3 x 10(- 3) 30 years after the emergence of the virus...
  46. ncbi The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis
    Yuquan Xie
    Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Virology 421:78-84. 2011
    ..The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC...
  47. ncbi [Etiology of hand, foot and mouth disease in Guangzhou in 2008]
    Bing Zhu
    Central Laboratory, Guangzhou Woman and Children s Medical Center, Guangzhou 510120, China
    Zhonghua Er Ke Za Zhi 48:127-30. 2010
    ..To understand the etiology of hand, foot and mouth disease (HFMD) in Guangzhou area in 2008...
  48. ncbi Evolutionary study on the Coxsackievirus A 24 variant causing acute hemorrhagic conjunctivitis by oligonucleotide mapping analysis of RNA genome
    K Miyamura
    Central Virus Diagnostic Laboratory, National Institute of Health, Tokyo, Japan
    Arch Virol 114:37-51. 1990
    ..The phylogenetic tree constructed indicates that CA 24 v appeared from one focal place in July 1968 +/- 25 months, very close to the time of the first world epidemic of, then newly recognized, acute hemorrhagic conjunctivitis...
  49. ncbi The outcome of coxsackievirus B3-(CVB3-) induced myocarditis is influenced by the cellular immune status
    C Leipner
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Herz 25:245-8. 2000
    ..with prolonged virus persistence in the heart tissue. Therefore, we suggest that despite an obvious normal T helper-1 cell cytokine pattern, IL-4-/- mice are more susceptible to long-term heart muscle injuries after infection with CVB3...
  50. pmc Distinct different expression of Th17 and Th9 cells in coxsackie virus B3-induced mice viral myocarditis
    Kong Qing
    Guangxi Cardiovascular Institute, Shuang Yong Road, Nanning, China
    Virol J 8:267. 2011
    ..Th17 cells have been shown to play a critical role in viral myocarditis (VMC), but whether Th9 cells are involved in the pathogenesis of VMC remains unclear...
  51. pmc Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
    Toru Kanno
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 80:5637-43. 2006
    ..While any CVB strain may be able to induce T1D in prediabetic NOD mice, T1D onset is linked both to the viral replication rate and infectious dose...
  52. ncbi The evidence of Coxsackievirus B3 induced myocarditis as the cause of death in a Sichuan snub-nosed monkey (Rhinopithecus roxellana)
    Wenqi He
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China
    J Med Primatol 38:192-8. 2009
    ..A 5-year-old female Sichuan snub-nosed monkey died at the zoological garden from infection with coxsackievirus B3...
  53. ncbi Coxsackievirus experimental heart diseases
    Charles Gauntt
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Front Biosci 8:e23-35. 2003
    ..Bed rest and supportive therapy are the current treatment for patients with myocarditis...
  54. pmc An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain
    Raina T Gay
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 103:13825-30. 2006
    ..These results demonstrate that the aged host promotes rapid selection of a pathogenic variant of CVB3 from an avirulent strain and introduces a host-virus paradigm for studies of viral infection in the aged...
  55. ncbi Expression of short hairpin RNAs against the coxsackievirus B3 exerts potential antiviral effects in Cos-7 cells and in mice
    Joo Young Kim
    Division of Intractable Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Republic of Korea
    Virus Res 125:9-13. 2007
    ..Through this direct evaluation system we addressed the development and application of vector-derived shRNAs as an anti-CVB3 agent, revealing new target sequences...
  56. ncbi [Alteration of Th17 cells in mice with coxsackie virus induced myocarditis]
    Fan Yang
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Xin Xue Guan Bing Za Zhi 38:790-3. 2010
    ..to observe the alteration of T helper cells 17(Th17) in mice with acute viral myocarditis (VMC) induced by coxsackie virus B3 (CVB3), explore the role of Th17 in mice VMC...
  57. pmc beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis
    Karin Klingel
    Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany
    Am J Pathol 162:1709-20. 2003
    ..Moreover, CVB3-induced cardiac injury and prevention of chronic myocarditis was found to be unrelated to perforin-mediated cytotoxicity in our model system...
  58. ncbi Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells
    P Ylipaasto
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Diabetologia 47:225-39. 2004
    ..We sought evidence for this through autopsy studies and by investigating known enterovirus receptors in cultured human islets...
  59. ncbi From infection to autoimmunity
    D Fairweather
    The Department of Pathology and The W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, Maryland, USA
    J Autoimmun 16:175-86. 2001
    ..These findings have broad implications for understanding the role of infection in inducing autoimmune disease...
  60. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
    ..IL-13 KO mice had increased caspase-1 activation, leading to increased production of both IL-1beta and IL-18. Therefore, IL-13 protects against myocarditis by modulating monocyte/macrophage populations and by regulating their function...
  61. ncbi Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets
    P Ylipaasto
    Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute, 00300 Helsinki, Finland
    Diabetologia 48:1510-22. 2005
    ..Exposure of cultured human islets to cytolytic enterovirus strains kills beta cells after a protracted period, suggesting a role for secondary virus-induced factors such as cytokines...
  62. ncbi Th17 cells contribute to viral replication in coxsackievirus B3-induced acute viral myocarditis
    Jing Yuan
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 185:4004-10. 2010
    ..These data suggest that Th17 cells contribute to CVB3 replication in AVMC, and that IL-17 might be an important target for regulating the balance of antiviral immunities...
  63. ncbi Simultaneous detection of human enterovirus 71 and coxsackievirus A16 in clinical specimens by multiplex real-time PCR with an internal amplification control
    Xing Long Xiao
    Department of Food, Institution of Food Safety, College of Light Industry and Food, South China University of Technology, Guangzhou, China
    Arch Virol 154:121-5. 2009
    ..By using an internal amplification control, the real-time assay achieves detection of samples containing inhibitors and avoids false negatives. It should prove useful for clinical diagnosis of EV71 or CV-A16 infections...
  64. ncbi IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Immunol 174:261-9. 2005
    ....
  65. ncbi Idiopathic dilated cardiomyopathy as a late complication of healed viral (Coxsackie B virus) myocarditis: historical analysis, review of the literature, and a postulated unifying hypothesis
    Michelle D Spotnitz
    Department of Medicine, St Luke s Roosevelt Hospital, New York, NY, USA
    Prog Cardiovasc Dis 49:42-57. 2006
    ..These studies allow for the proposal of a hypothetical mechanism whereby IDCM develops as a downstream complication of acute viral myocarditis...
  66. pmc Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis
    S Van Linthout
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Campus Virchow, Berlin, Germany
    Eur Heart J 32:2168-78. 2011
    ..Finally, we investigated whether MSC application could improve murine acute CVB3-induced myocarditis...
  67. ncbi Protective effects of carvedilol in murine model with the coxsackievirus B3-induced viral myocarditis
    Li Yue-Chun
    Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    J Cardiovasc Pharmacol 51:92-8. 2008
    ..The results indicate that the superior protection of carvedilol in this model is probably the result of its antioxidative effects and the upregulation of antiinflammatory cytokines...
  68. ncbi Recombinant lentivirus-delivered short hairpin RNAs targeted to conserved coxsackievirus sequences protect against viral myocarditis and improve survival rate in an animal model
    Yeon Jung Kim
    Department of Biotechnology, The Catholic University of Korea, 43 1, Yeokgok 2 dong, Wonmi gu, Bucheon si, Gyeonggi do 420 743, Korea
    Virus Genes 36:141-6. 2008
    ..Moreover, Met-2C lenti improved survival rate compared with that of the GFP lenti infected control group. Therefore, Met-2C lenti is potentially a clinical therapeutic agent for the treatment of viral myocarditis...
  69. ncbi A recent epidemic of acute hemorrhagic conjunctivitis
    M Yin Murphy
    Department of Microbiology, Faculty of Medicine, National University of Singapore
    Am J Ophthalmol 116:212-7. 1993
    ..Apart from conjunctival secretions, respiratory and oral transmission of coxsackievirus A24 variant would explain the rapid and extensive spread of acute hemorrhagic conjunctivitis during an outbreak...
  70. ncbi [Role of interleukin 17 in viral myocarditis and dilated cardiomyopathy]
    Song Lin
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:1994-9. 2009
    ..To explore the role of interleukin-17 (IL-17) in the evolution of viral myocarditis (VMC) into dilated cardiomyopathy (DCM)...
  71. pmc Depletion of gammadelta+ T cells increases CD4+ FoxP3 (T regulatory) cell response in coxsackievirus B3-induced myocarditis
    Sally A Huber
    Department of Pathology, University of Vermont, Colchester, VT 05446, USA
    Immunology 127:567-76. 2009
    ..This study shows that gammadelta(+) cells promote CD4(+) IFN-gamma(+) acute and memory responses by limiting FoxP3(+) T regulatory cell activation...
  72. ncbi Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy
    Henry Fechner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Mol Med (Berl) 86:987-97. 2008
    ..5 vs. 16.2 +/- 1.1 ms (p < 0.01). The data show, for the first time, that intravenously injected AAV9 has the potential to target RNAi to the heart and suggest AAV9-shRNA vectors as a novel therapeutic approach for cardiac disorders...
  73. pmc Inhibition of coxsackievirus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand
    Ji Yuan
    Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia St Paul s Hospital, Vancouver, British Columbia, Canada
    J Virol 79:2151-9. 2005
    ..These findings reveal an effective target for CVB3 silencing and provide a new possibility for antiviral intervention...
  74. ncbi Inhibition of coxsackievirus B3 carrier state infection of cultured human myocardial fibroblasts by ribavirin and human natural interferon-alpha
    A Heim
    Institute for Virology, Medizinische Hochschule Hannover, Germany
    Antiviral Res 34:101-11. 1997
    ..Furthermore, the usefulness of in situ hybridization for determining the long term effects of antivirals in carrier state cell cultures was demonstrated...
  75. ncbi Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis
    Jun Li
    Department of Internal Medicine II, Charite Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Pharmacol 554:60-8. 2007
    ..A significant suppression of MMPs may mainly contribute to an improvement of left ventricular dysfunction in acute murine CVB3-induced myocarditis...
  76. ncbi Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
    Ya Feng Wang
    Institute of Pharmacology Science, Jinan University Guangdong, Guangzhou, China
    Antiviral Res 84:150-8. 2009
    ..These results show that Phyllaemblicin B exerts significant antiviral activities against CVB3. Therefore, Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis...
  77. ncbi Remission of CVB3-induced viral myocarditis by in vivo Th2 polarization via hydrodynamics-based interleukin-4 gene transfer
    Zhenggang Jiang
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    J Gene Med 10:918-29. 2008
    ..In the present study, interleukin (IL)-4 was over-expressed by hydrodynamics-based gene transfection (HGT) to induce the in vivo Th2 bias and evaluate the influence of Th polarization on the pathogenesis of CVB3-myocaditis...
  78. ncbi Coxsackieviral-mediated diabetes: induction requires antigen-presenting cells and is accompanied by phagocytosis of beta cells
    Marc S Horwitz
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Immunol 110:134-44. 2004
    ..This generalized mechanism suggests that macrophages are the initiating pathogenic cell type during virus-mediated autoimmune diabetes and that multiple environmental agents specific for beta cells could cause IDDM...
  79. ncbi Coxsackievirus infections and NOD mice: relevant models of protection from, and induction of, type 1 diabetes
    Steven Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha NE 68198, USA
    Ann N Y Acad Sci 1103:143-51. 2007
    ..These models expand much of what is known or suspected regarding the etiologic role of HEVs in human T1D...
  80. ncbi Persistent expression of cytokines in the chronic stage of CVB3-induced myocarditis in NMRI mice
    B Gluck
    Institute of Virology at the Medical Center of the Friedrich Schiller University, Jena, Germany
    J Mol Cell Cardiol 33:1615-26. 2001
    ....
  81. ncbi Identification of HLA-A*01- and HLA-A*02-restricted CD8+ T-cell epitopes shared among group B enteroviruses
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Gen Virol 89:2090-7. 2008
    ..All four epitopes were homologous in 36-92% of group B enteroviruses, providing a strong basis for monitoring the divergence of T-cell-based immune responses in enterovirus-induced acute and chronic diseases...
  82. ncbi Localized thigh swelling mimicking a neoplastic process: involvement of coxsackie virus type A21
    B Dekel
    Department of Pediatrics and Central Virology Laboratory, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Acta Paediatr 91:357-9. 2002
    ..Clinical symptomatology subsided with oral steroids...
  83. ncbi Pediatric group B coxsackievirus infections
    J R Romero
    University of Nebraska Medical Center, 986495 Nebraska Medical, Omaha, NE 68198 6495, USA
    Curr Top Microbiol Immunol 323:223-39. 2008
    ..This review will focus on the more common or clinically relevant CVB-related syndromes, their diagnosis, treatment, and prevention...
  84. ncbi Toll-like receptor 4-induced cytokine production circumvents protection conferred by TGF-beta in coxsackievirus-mediated autoimmune myocarditis
    Martin J Richer
    Microbiology and Immunology, The University of British Columbia, 3551 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Clin Immunol 121:339-49. 2006
    ..Interestingly, the action of LPS (TLR-4) did not alter antibody isotype switching, increase viral replication or modulate CD40 expression. Instead, LPS breaks protection through an alternative mechanism specific to TLR-4 signaling...
  85. ncbi Host immune responses to coxsackievirus B3
    S Huber
    University of Vermont, Burlington, VT 05405, USA
    Curr Top Microbiol Immunol 323:199-221. 2008
    ....
  86. pmc Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication
    Isabelle P Hunziker
    Molecular and Integrative Neurosciences Department, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 360:120-8. 2007
    ....
  87. pmc Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection
    Christopher C Kemball
    Molecular and Integrative Neurosciences Dept, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 82:4331-42. 2008
    ..Finally, our findings have implications for the biological significance of cross-priming, a process thought by some to be important for the induction of antiviral CD8(+) T-cell responses...
  88. ncbi Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta
    Martin J Richer
    Department of Microbiology and Immunology, The University of British Columbia, 3551 2350 Health Sciences Mall, Vancouver, BC, Canada
    Diabetes 57:1302-11. 2008
    b>Coxsackievirus infections have long been associated with the induction of type 1 diabetes...
  89. ncbi Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection
    Andrea Dorner
    Department of Medicine, University of California, San Diego, California 92093, USA
    J Biol Chem 279:18497-503. 2004
    ....
  90. ncbi Immunopathology during coxsackievirus infection
    J Lindsay Whitton
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Springer Semin Immunopathol 24:201-13. 2002
  91. ncbi Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells
    Matthijs Kramer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Scinces and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmigen Medical Centre, The Netherlands
    Cell Microbiol 9:1507-18. 2007
    ..These results describe for the first time the effect of EV on the function and viability of human DCs and suggest that infection of DCs in vivo can impede regulation of immune responses...
  92. ncbi IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection
    Michael H Hühn
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Cell Microbiol 10:426-36. 2008
    ....
  93. ncbi Suppression of proinflammatory cytokines and induction of IL-10 in human monocytes after coxsackievirus B3 infection
    P Hofmann
    Institute of Immunology, Philipps University Marburg, Marburg, Germany
    J Med Virol 64:487-98. 2001
    ..This viral strategy may aid CVB3, causing chronic myocardiopathy...
  94. pmc Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1
    Stephen J Crocker
    Molecular and Integrative Neurosciences Dept, SP30 2110, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Pathol 171:1762-73. 2007
    ..These unexpected findings indicate that increased TIMP-1 expression exacerbates, rather than ameliorates, CVB3-induced myocarditis and, thus, that TIMP-1 may represent a target for the treatment of virus-induced heart disease...
  95. pmc Using recombinant coxsackievirus B3 to evaluate the induction and protective efficacy of CD8+ T cells during picornavirus infection
    M K Slifka
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:2377-87. 2001
    ..8% of myocardial viruses. Together, these results show that expression of heterologous viral proteins by recombinant CVB3 provides a useful model for determining the mechanisms underlying the immune response to this viral pathogen...
  96. ncbi Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS
    Ralph Feuer
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 25:2434-44. 2005
    ..These data lead us to propose a model of CVB infection of the developing CNS, which may explain the neurodevelopmental defects that result from fetal infection...
  97. ncbi Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets
    D V Serreze
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Diabetes 49:708-11. 2000
    b>Coxsackievirus infections have been proposed as an environmental trigger for the development of T-cell-mediated autoimmune (type 1) diabetes by either providing a molecular mimic of the candidate pancreatic beta-cell autoantigen GAD or ..
  98. ncbi Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection
    G M Schiff
    Gamble Program for Clinical Studies, Division of Infectious Diseases, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Infect Dis 181:20-6. 2000
    ..The most common adverse events were nausea and abdominal pain. These data support the safety and efficacy of pleconaril in decreasing the signs and symptoms and viral shedding associated with a viral respiratory infection...
  99. ncbi Cytokine profiles in heart, spleen, and thymus during the acute stage of experimental coxsackievirus B3-induced chronic myocarditis
    M Schmidtke
    Institute of Virology at the Medical Center of the Friedrich Schiller University, Jena, Germany
    J Med Virol 61:518-26. 2000
    ....
  100. pmc Molecular epidemiology of a variant of coxsackievirus A24 in Taiwan: two epidemics caused by phylogenetically distinct viruses from 1985 to 1989
    K H Lin
    Department of Clinical Laboratory, Kaohsiung Medical College, Taipei, Taiwan, Republic of China
    J Clin Microbiol 31:1160-6. 1993
    ..The evidence revealed that Taiwan has had two repeated but discontinuous introductions of CA24v since its first appearance in Taiwan in 1985. None of the other CA24v strains have been detected so far...
  101. ncbi Autoimmunity in coxsackievirus infection
    N R Rose
    Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, 615 N Wolfe St, E5009, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 323:293-314. 2008
    ..Many of the lessons learned from study of these models are applicable to human myocarditis and dilated cardiomyopathy...

Research Grants32

  1. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  2. DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    Michael Irwin; Fiscal Year: 2003
    ....
  3. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  4. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  5. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  6. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  7. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. Nutrition, Viral Mutation and Host Defense
    Melinda Beck; Fiscal Year: 2007
    ..abstract_text> ..
  9. The Influence of Nutrition on Influenza Virus Infection
    Melinda Beck; Fiscal Year: 2004
    ..abstract_text> ..
  10. Enterovirus persistence in myocarditis
    Nora Chapman; Fiscal Year: 2003
    ....
  11. Cardiac SOCS Proteins: A Role in Enterovirus Infection
    Kirk Knowlton; Fiscal Year: 2007
    ..These aims will provide a novel insight into the mechanisms by which JAK-STAT-SOCS activation within the cardiac myocyte regulates the innate anti-viral response. ..
  12. Dystrophin-glycoprotein complex in viral cardiomyopathy
    Kirk Knowlton; Fiscal Year: 2004
    ..4. Determine whether conditional expression of Coxsackieviral protease 2A in the cardiac myocyte is sufficient to induce cardiomyopathy and disruption of the sarcolemma via cleavage of dystrophin. ..
  13. Genetic mechanisms of autoimmune myocarditis
    Noel Rose; Fiscal Year: 2007
    ..We build on our preliminary data to propose hypothesis-driven aims to identify host genes that control susceptibility and characterize their mechanisms of action in a murine model of autoimmune myocarditis. ..
  14. THE ROLE OF IMMUNE RESPONSES IN ALCOHOLIC LIVER DISEASE
    THOMAS JERRELLS; Fiscal Year: 2007
    ..4. To define the role of NK cells in the hepatitis associated with MCMV infection of alcohol-fed mice. ..
  15. Effects of Ethanol on Pancreas Regeneration
    Dahn Clemens; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..
  17. Pathogenesis of Autoimmune Myocarditis
    Noel Rose; Fiscal Year: 2009
    ..We propose to broaden our knowledge of the pathogenesis of myocarditis, in order to rationalize new biologic approaches to treatment. ..
  18. HIV vaccine development using recombinant coxsackieviruses
    ARLENE RAMSINGH; Fiscal Year: 2010
    ..The present proposal describes a new approach to augment HIV-specific immune responses and to minimize the problem of escape mutants. ..
  19. ETHANOL OXIDATION EFFECTS ON EGF SIGNAL TRANSDUCTION
    Dahn Clemens; Fiscal Year: 2001
    ....
  20. Cell/Tissue Damage and Autoimmune Response
    Noel Rose; Fiscal Year: 2006
    ..Overall, we anticipate a faculty of 25 to 30 speakers, and about 75 to 100 attendees. After the colloquium, our ultimate goal is to publish the meeting report in a well-circulated journal. ..
  21. Role of innate immunity in autoimmune myocarditis
    Noel Rose; Fiscal Year: 2005
    ..The findings generated by these studies will aid in understanding the development of autoimmune disease initiated by infection. ..
  22. IMMUNOMODULATION OF RETROVIRAL CARDIOPATHOLOGY
    RONALD WATSON; Fiscal Year: 2001
    ..The treatments that found to prevent cytokine dysregulation and cardiotoxicitiy in retrovirally infected mice will then be applicable to reducing heart disease in HIV infected patients (End of Abstract) ..
  23. NON T CELL PRODUCED NOVEL T CELL GROWTH FACTORS
    Terry Strom; Fiscal Year: 2002
    ....
  24. ALCOHOL INDUCED IMMUNOMODULATION--RETROVIRAL CARDIOPATH
    RONALD WATSON; Fiscal Year: 2003
    ..Such studies could provide the basis for their application to reduce heart disease in alcohol-abusing, HIV-infected patients. ..
  25. T cell immunity to HIV using recombinant enteroviruses
    ARLENE RAMSINGH; Fiscal Year: 2003
    ..Recombinants that can elicit T cell immunity against HIV could be part of a "cocktail" of immunogens used as a preventive HIV vaccine. ..
  26. Sex differences in Coxsackievirus-induced myocarditis
    Noel Rose; Fiscal Year: 2004
    ..The findings generated by these studies will aid in understanding the sex- based differences in severity in this model of infection-induced autoimmune disease. ..
  27. BIOCHEMISTRY AND IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE
    THOMAS JERRELLS; Fiscal Year: 2004
    ..The ultimate goal of this training program is to prepare both basic scientists and clinically trained scientists for an active and productive research career on the effects of alcohol on the liver. ..
  28. Novel Approaches To Achieve Allograft Tolerance
    Terry Strom; Fiscal Year: 2005
    ..6) determine whether an idealized therapeutic and diagnostic protocol can be established through knowledge gained from the combined efforts of each of the components of this project. ..
  29. A ROLE FOR VIRAL INFECTION IN ALCOHOLIC PANCREATITIS
    THOMAS JERRELLS; Fiscal Year: 2005
    ..The model system will also allow critical studies of possible therapeutic interventions. ..
  30. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  31. MECHANISM OF ETHANOL INDUCED IMPAIRMENTS IN IMMUNITY
    THOMAS JERRELLS; Fiscal Year: 2002
    ..By using the various infectious model systems in place in this laboratory the ETOH-mediated effects on the subsets of helper T cells (TH-1 and TH-2) will also be defined. ..