orthomyxoviridae infections

Summary

Summary: Virus diseases caused by the ORTHOMYXOVIRIDAE.

Top Publications

  1. ncbi The multifunctional NS1 protein of influenza A viruses
    Benjamin G Hale
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    J Gen Virol 89:2359-76. 2008
  2. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
  3. pmc A highly conserved neutralizing epitope on group 2 influenza A viruses
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 333:843-50. 2011
  4. pmc Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
    John R Teijaro
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 146:980-91. 2011
  5. pmc The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 30:556-65. 2009
  6. ncbi Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines
    R J Cox
    Influenza Research Centre Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 59:1-15. 2004
  7. pmc Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection
    Daniela Damjanovic
    Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 179:2963-76. 2011
  8. ncbi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
  9. ncbi Influenza A viruses: new research developments
    Rafael A Medina
    Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine
    Nat Rev Microbiol 9:590-603. 2011
  10. pmc Modeling within-host dynamics of influenza virus infection including immune responses
    Kasia A Pawelek
    Department of Mathematics and Statistics, Oakland University, Rochester, Michigan, United States of America
    PLoS Comput Biol 8:e1002588. 2012

Research Grants

  1. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
  2. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
  3. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
  4. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
  5. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
  6. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  8. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
  9. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
  10. Novel broad spectrum vaccination against influenza
    Petr Ilyinskii; Fiscal Year: 2006

Detail Information

Publications283 found, 100 shown here

  1. ncbi The multifunctional NS1 protein of influenza A viruses
    Benjamin G Hale
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    J Gen Virol 89:2359-76. 2008
    ....
  2. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
    ..Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses...
  3. pmc A highly conserved neutralizing epitope on group 2 influenza A viruses
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 333:843-50. 2011
    ..Thus, a cocktail of two antibodies may be sufficient to neutralize most influenza A subtypes and, hence, enable development of a universal flu vaccine and broad-spectrum antibody therapies...
  4. pmc Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
    John R Teijaro
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 146:980-91. 2011
    ..Modulation of endothelium with a specific agonist suggests that diseases in which amplification of cytokine storm is a significant pathological component could be chemically tractable...
  5. pmc The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 30:556-65. 2009
    ..Together, these data place the NLRP3 inflammasome as an essential component in host defense against influenza infection through the sensing of viral RNA...
  6. ncbi Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines
    R J Cox
    Influenza Research Centre Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 59:1-15. 2004
    ..In contrast, the CAV may elicit a long-lasting, broader immune (humoral and cellular) response, which more closely resembles natural immunity. The immune response induced by these two vaccines will be compared in this review...
  7. pmc Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection
    Daniela Damjanovic
    Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 179:2963-76. 2011
    ..Thus, TNF-α is dispensable for influenza clearance; however, different from the traditional belief, this cytokine is critically required for negatively regulating the extent of lung immunopathology during acute influenza infection...
  8. ncbi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
  9. ncbi Influenza A viruses: new research developments
    Rafael A Medina
    Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine
    Nat Rev Microbiol 9:590-603. 2011
    ..We also revise the lessons that have been learnt from the pandemic viruses of the past 100 years...
  10. pmc Modeling within-host dynamics of influenza virus infection including immune responses
    Kasia A Pawelek
    Department of Mathematics and Statistics, Oakland University, Rochester, Michigan, United States of America
    PLoS Comput Biol 8:e1002588. 2012
    ..This study provides a quantitative understanding of the biological factors that can explain the viral and interferon kinetics during a typical influenza virus infection...
  11. pmc Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus
    Balaji Manicassamy
    Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:11531-6. 2010
    ....
  12. pmc Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection
    Bruno Moltedo
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 7:e1002345. 2011
    ..Conversely, this trait may be exploitable by viral pathogens as a mechanism for systemic dissemination...
  13. pmc IFITM3 restricts the morbidity and mortality associated with influenza
    Aaron R Everitt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 484:519-23. 2012
    ..Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans...
  14. pmc The role of neutrophils during mild and severe influenza virus infections of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 6:e17618. 2011
    ....
  15. ncbi Genome packaging in influenza A virus
    Edward C Hutchinson
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Gen Virol 91:313-28. 2010
    ..This review summarizes work leading to this conclusion. In addition, we describe recent progress in identifying the specific packaging signals and discuss likely mechanisms by which these RNA elements might operate...
  16. ncbi Induction of broadly neutralizing H1N1 influenza antibodies by vaccination
    Chih Jen Wei
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892 3005, USA
    Science 329:1060-4. 2010
    ..Cross-neutralization of H1N1 subtypes elicited by this approach provides a basis for the development of a universal influenza vaccine for humans...
  17. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ....
  18. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
    ..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
  19. pmc Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host
    Yuwei Gao
    Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
    PLoS Pathog 5:e1000709. 2009
    ..These amino acids changes in PB2 and HA could serve as important molecular markers for assessing the pandemic potential of H5N1 field isolates...
  20. ncbi Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
    Gavin J D Smith
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Nature 459:1122-5. 2009
    ..Our results highlight the need for systematic surveillance of influenza in swine, and provide evidence that the mixing of new genetic elements in swine can result in the emergence of viruses with pandemic potential in humans...
  21. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
    ..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
  22. pmc Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1
    Stephen Mark Tompkins
    Food and Drug Administration, Bethesda, Maryland, USA
    Emerg Infect Dis 13:426-35. 2007
    ..This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A...
  23. pmc The ferret as a model organism to study influenza A virus infection
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dis Model Mech 4:575-9. 2011
    ..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions...
  24. pmc Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States
    Mariette F Ducatez
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 3678, USA
    Emerg Infect Dis 17:1624-9. 2011
    ..These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversification occurs in this ecologically important viral reservoir...
  25. pmc High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 82:5650-2. 2008
    ..Our data imply that contact or short-range spread predominates in the tropics and offer an explanation for the lack of a well-defined, recurrent influenza season affecting tropical and subtropical regions of the world...
  26. pmc Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus
    T C Dawson
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 156:1951-9. 2000
    ....
  27. pmc Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus
    Mark W Lamere
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 186:4331-9. 2011
    ..The high conservation of NP Ag and the known longevity of Ab responses suggest that anti-NP IgG may provide a critically needed component of a universal influenza vaccine...
  28. pmc IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge
    K Kai McKinstry
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 182:7353-63. 2009
    ..Our results show that IL-10 expression inhibits development of Th17 responses during influenza infection and that this is correlated with compromised protection during high-dose primary, but not secondary, challenge...
  29. pmc Reassortment of pandemic H1N1/2009 influenza A virus in swine
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Science 328:1529. 2010
    ..Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted...
  30. pmc Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
    Teluguakula Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Am J Pathol 179:199-210. 2011
    ..These findings support the pathogenic effects of excessive neutrophils in acute lung injury of influenza pneumonia by instigating alveolar-capillary damage...
  31. ncbi Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Immunol 183:7441-50. 2009
    ..Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease...
  32. pmc Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes
    Cristian Cilloniz
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 5:e1000604. 2009
    ....
  33. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
  34. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
    ..Taken together, these studies demonstrate that the 2009 H1N1 viruses exhibited mild to moderate virulence in mice compared with highly pathogenic viruses...
  35. pmc Global transmission of influenza viruses from humans to swine
    Martha I Nelson
    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Gen Virol 93:2195-203. 2012
    ....
  36. ncbi Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
    Andrea Jegerlehner
    Cytos Biotechnology, Schlieren, Switzerland
    J Immunol 172:5598-605. 2004
    ....
  37. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    ....
  38. pmc Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 5:e1000252. 2009
    ..Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds...
  39. pmc Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus
    Carole R Baskin
    Washington National Primate Research Center, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:3455-60. 2009
    ....
  40. pmc Commensal bacteria calibrate the activation threshold of innate antiviral immunity
    Michael C Abt
    Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 37:158-70. 2012
    ..Collectively, these data indicate that commensal-derived signals provide tonic immune stimulation that establishes the activation threshold of the innate immune system required for optimal antiviral immunity...
  41. ncbi Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
    ..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
  42. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
    ..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
  43. ncbi Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection
    Keer Sun
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA
    Nat Med 14:558-64. 2008
    ..Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung...
  44. pmc Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques
    David Safronetz
    Laboratory of Virology, Hamilton, Montana, USA
    J Virol 85:1214-23. 2011
    ..Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans...
  45. pmc Host genetic background strongly influences the response to influenza a virus infections
    Barkha Srivastava
    Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    PLoS ONE 4:e4857. 2009
    ..The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses...
  46. ncbi Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice
    Anupa Kudva
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    J Immunol 186:1666-74. 2011
    ..These data indicate a novel mechanism by which influenza A-induced type I IFNs inhibit Th17 immunity and increase susceptibility to secondary bacterial pneumonia...
  47. pmc Influenza A virus utilizes suboptimal splicing to coordinate the timing of infection
    Mark A Chua
    Microbiology Graduate School Training Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Rep 3:23-9. 2013
    ..Together, these data demonstrate that coordination of the influenza A virus life cycle is set by a "molecular timer" that operates on the inefficient splicing of a virus transcript...
  48. ncbi Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
    James W Huleatt
    VaxInnate Corporation, 300 George Street, New Haven, CT 06511, USA
    Vaccine 26:201-14. 2008
    ..These data demonstrate that the linkage of specific TLR ligand with influenza M2e yields a vaccine candidate that offers significant promise for widespread protection against multiple influenza A virus strains...
  49. ncbi Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung
    Cherrie Lee Small
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    J Immunol 184:2048-56. 2010
    ..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection...
  50. pmc Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection
    John R Teijaro
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 187:5510-4. 2011
    ..Our results reveal tissue compartmentalization as a major determining factor for immune-mediated protection in a key mucosal site, important for targeting local protective responses in vaccines and immunotherapies...
  51. pmc Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice
    Shigeki Nakamura
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6076, USA
    J Clin Invest 121:3657-65. 2011
    ....
  52. pmc Evolution of novel reassortant A/H3N2 influenza viruses in North American swine and humans, 2009-2011
    Martha I Nelson
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:8872-8. 2012
    ..The identification of this N2 variant may have implications for influenza vaccine design and the potential pandemic threat of H3N2v to human age groups with differing levels of prior exposure and immunity...
  53. pmc Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein
    Ronan Le Goffic
    Unite de Virologie et Immunologie Moleculaires, UR 892 INRA, Jouy en Josas, France
    PLoS Pathog 7:e1002202. 2011
    ..Collectively, these data demonstrate that PB1-F2 strongly influences the early host response during IAV infection and provides new insights into the mechanisms by which PB1-F2 mediates virulence...
  54. pmc Spatial dynamics of human-origin H1 influenza A virus in North American swine
    Martha I Nelson
    Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1002077. 2011
    ....
  55. ncbi Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells
    Adrian W S Ho
    Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore 117456
    J Immunol 187:6011-21. 2011
    ..Collectively, these results show that CD11b(low/neg)CD103(+) DCs are functionally specialized for the transport of Ag from the lung to the lymph node and also for efficient processing and presentation of viral Ags to CD8 T cells...
  56. ncbi Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    ..These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences...
  57. pmc Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Korea
    J Virol 82:4265-74. 2008
    ..Taken together, our findings suggest that alveolar macrophages are essential for controlling H1N1 influenza viruses in pigs...
  58. pmc Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humans
    Huachen Zhu
    International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
    J Virol 85:10432-9. 2011
    ..Immunization against the 2009 pandemic virus gave only partial protection to ferrets. The continuing prevalence of the pdm/09 virus in pigs could lead to the genesis of novel swine reassortant viruses with the potential to infect humans...
  59. pmc Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins
    Taia T Wang
    Department of Microbiology Mount Sinai School of Medicine New York, New York, United States of America
    PLoS Pathog 6:e1000796. 2010
    ..Importantly, our antibodies are of naturally occurring specificity rather than selected from cloned libraries, demonstrating that broad-spectrum humoral immunity to influenza viruses can be elicited in vivo...
  60. pmc Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Infect Dis 202:1287-95. 2010
    ..Overall, these data argue that the relationship between respiratory viral infections, acquisition of pneumococci, and development of disease in humans needs further study to be better understood...
  61. pmc TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    Jerry R Aldridge
    Division of Virology, Department of Infectious Diseases, and Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:5306-11. 2009
    ..Targeting the tipDCs in this way thus offers possibilities for therapeutic intervention in the face of a catastrophic pandemic...
  62. ncbi Innate immune responses to influenza A H5N1: friend or foe?
    Joseph Sriyal Malik Peiris
    Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong SAR
    Trends Immunol 30:574-84. 2009
    ....
  63. pmc Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?
    Kendall P Myers
    Center for Emerging Infectious Diseases, Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Clin Infect Dis 42:14-20. 2006
    ..Pigs have an important role in interspecies transmission of the virus. We examined multiple swine-exposed human populations in the nation's number 1 swine-producing state for evidence of previous swine influenza virus infection...
  64. pmc Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
    Arash Shahangian
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 119:1910-20. 2009
    ..Collectively, these findings highlight what we believe to be a novel mechanism by which the antiviral response to influenza sensitizes hosts to secondary bacterial pneumonia...
  65. ncbi Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform
    Jérôme Denis
    Centre de Recherche en Infectiologie, Pavillon CHUL, Universite Laval, 2705 Boulevard Laurier, Quebec, PQ, G1V 4G2 Canada
    Vaccine 26:3395-403. 2008
    ..These results show, for the first time, the potential of a recombinant plant virus protein to serve as both peptide delivery system and adjuvant in the crucial field of influenza vaccine development...
  66. pmc Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms
    John R Teijaro
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Virol 84:9217-26. 2010
    ..These findings have important implications for the generation of universal influenza vaccines by promoting long-lived protective CD4 T-cell responses...
  67. pmc Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes
    Taia T Wang
    Department of Microbiology and Medicine, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:18979-84. 2010
    ..These results provide proof of concept for an HA2-based influenza vaccine that could diminish the threat of pandemic influenza disease and generally reduce the significance of influenza viruses as human pathogens...
  68. pmc Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses
    Markus Mordstein
    Department of Virology, University of Freiburg, Freiburg, Germany
    PLoS Pathog 4:e1000151. 2008
    ..From these results we conclude that IFN-lambda contributes to inborn resistance against viral pathogens infecting the lung but not the liver...
  69. pmc Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates
    Jason T Weinfurter
    Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America
    PLoS Pathog 7:e1002381. 2011
    ..Vaccines capable of inducing such cross-reactive T cells may help protect humans against severe disease caused by newly emerging pandemic influenza viruses...
  70. ncbi Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1
    Roi Gazit
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 7:517-23. 2006
    ..We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus...
  71. ncbi Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice
    Roman Seyer
    Institute of Molecular Virology, ZMBE, Muenster, Germany
    J Infect Dis 205:262-71. 2012
    ..In conclusion, synergistic action of all 3 mutations results in a mice lethal pandemic H1N1 virus...
  72. pmc Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance
    Mark W Lamere
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Virol 85:5027-35. 2011
    ..The high conservation of NP antigen and the known longevity of antibody responses suggest that the antiviral activity of anti-NP IgG may provide a critically needed component of a universal influenza vaccine...
  73. ncbi Swine influenza viruses a North American perspective
    Amy L Vincent
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA ARS, Ames, Iowa 50010, USA
    Adv Virus Res 72:127-54. 2008
    ....
  74. pmc Modeling host responses in ferrets during A/California/07/2009 influenza infection
    Thomas Rowe
    International Institute of Infection and Immunity at Shantou Medical College, 22 Xingling Rd, Shantou, Guangdong 515041, People s Republic of China
    Virology 401:257-65. 2010
    ..We propose that lung pathology in humans occurs during the innate phase of host immunity and a delay or failure to switch to the adaptive phase may contribute to morbidity and mortality during severe 2009-H1N1 infections...
  75. ncbi Activation of toll-like receptor signaling pathway for protection against influenza virus infection
    J P Wong
    Biotechnology Section, Defence R and D Canada Suffield, Ralston, Alberta, Canada
    Vaccine 27:3481-3. 2009
    ..Taken together, these results do support the potential role of TLR-3 and TLR-9 agonists such as Poly ICLC and LE Poly ICLC in protection against lethal seasonal and HPAI virus infection...
  76. pmc Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses
    Makoto Ozawa
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 575 Science Drive, Madison, WI 53711, USA
    J Virol 85:4596-601. 2011
    ..Our results suggest that some NS1 mutations and the newly identified PB1-F2 mutation have the potential to increase the replication and/or pathogenicity of pandemic (H1N1) 2009 influenza viruses...
  77. pmc Influenza virus aerosol exposure and analytical system for ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 108:8432-7. 2011
    ..These methods will provide improved risk assessment of emerging influenza viruses that pose a threat to public health...
  78. pmc A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
    Akila Jayaraman
    Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17616. 2011
    ..These findings are significant in the context of monitoring the evolution of the currently circulating 2009 H1N1 viruses...
  79. pmc Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells
    Hirokazu Hikono
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 204:1625-36. 2007
    ..These findings extend our understanding of how recall responses are generated and suggest that activation and migration markers define distinct, and unrelated, characteristics of memory T cells...
  80. pmc Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice
    Adrianus C M Boon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 83:10417-26. 2009
    ..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
  81. ncbi Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2
    Krystyna Mozdzanowska
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4268, USA
    Vaccine 21:2616-26. 2003
    ..Importantly, the protection in M2e-MAP- and infection-immunized mice appeared to be mediated by distinct immune mechanisms. This suggests that stronger protection may be achievable by combining both protective activities...
  82. pmc Intra- and interhost evolutionary dynamics of equine influenza virus
    Pablo R Murcia
    Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES Cambridge, England, United Kingdom
    J Virol 84:6943-54. 2010
    ....
  83. ncbi Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
    Patrick C Reading
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3391-8. 2008
    ....
  84. ncbi The epidemiology and evolution of influenza viruses in pigs
    I H Brown
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK
    Vet Microbiol 74:29-46. 2000
    ..Both human H3N2 and avian H1N1 were detected in pigs many years before they acquired the ability to spread rapidly and become associated with disease epidemics in pigs...
  85. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  86. pmc Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release
    Rahul K Nelli
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, United Kingdom
    J Virol 86:9201-10. 2012
    ....
  87. ncbi Influenza A virus infection dynamics in swine farms in Belgium, France, Italy and Spain, 2006-2008
    C S Kyriakis
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Vet Microbiol 162:543-50. 2013
    ..This can either be explained by the persistence of the virus in a farm, or by the periodical re-introduction of SIVs of the same subtype...
  88. ncbi Genomic characterization of H1N2 swine influenza viruses in Italy
    Ana Moreno
    Department of Virology, Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna, Via Bianchi, 9, 25124 Brescia, Italy
    Vet Microbiol 156:265-76. 2012
    ..These findings also highlighted different genomic characteristics of the NA gene the recent Italian strains compared to circulating European viruses...
  89. pmc Emergence of fatal avian influenza in New England harbor seals
    S J Anthony
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    MBio 3:e00166-12. 2012
    ..The emergence of this A/harbor seal/Massachusetts/1/2011 virus may herald the appearance of an H3N8 influenza clade with potential for persistence and cross-species transmission...
  90. pmc Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Virol 84:7569-80. 2010
    ..Furthermore, the inability of PR8 to infect airway macrophages may be a critical factor contributing to its virulence for mice...
  91. pmc Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling
    Linda M Bradley
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS Pathog 8:e1002641. 2012
    ....
  92. pmc A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus
    Damian M Carragher
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:4168-76. 2008
    ..These results suggest that vaccines designed to elicit optimal heterosubtypic immunity to influenza should promote both Ab and T cell responses to conserved internal proteins...
  93. pmc Evolution of an Eurasian avian-like influenza virus in naïve and vaccinated pigs
    Pablo R Murcia
    Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Pathog 8:e1002730. 2012
    ..This implies that mutations that reduce viral fitness in one host, but which could lead to fitness benefits in a novel host, can circulate at low frequencies...
  94. pmc Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 146421, USA
    J Virol 84:6687-98. 2010
    ..Also, simulation studies were performed to understand the relative contributions of biological parameters to IAV clearance. This study provides a basis to better understand and predict influenza virus immunity...
  95. pmc Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge
    B S Bender
    Department of Medicine, University of Florida College of Medicine, Gainesville
    J Exp Med 175:1143-5. 1992
    ..Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections...
  96. pmc Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection
    Amanda M Jamieson
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Host Microbe 7:103-14. 2010
    ..This study demonstrates that activation of the hypothalamic-pituitary-adrenal axis controls the balance between immune defense and immunopathology and is an important component of the host response to coinfection...
  97. ncbi Long-term evolution and transmission dynamics of swine influenza A virus
    Dhanasekaran Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Nature 473:519-22. 2011
    ..Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans...
  98. ncbi Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction
    Nicholas Svitek
    INRS Institut Armand Frappier, University of Quebec, Laval, QC, Canada
    Virology 376:53-9. 2008
    ..These findings suggest that more virulent strains may interfere more efficiently with the host response at early disease stages...
  99. pmc Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs
    Sharon M Brookes
    Veterinary Laboratories Agency Weybridge, EU OIE FAO Reference Laboratory for Avian Influenza and Newcastle Disease, Addlestone, Surrey, United Kingdom
    PLoS ONE 5:e9068. 2010
    ..These findings provide potential clues to the existence and biological significance of viral receptor-binding variants with 225D and 225G during the 1918 pandemic [5]...
  100. pmc The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells
    Karen Y Twu
    Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA
    J Virol 81:8112-21. 2007
    ..Consequently, these internal HK97 proteins largely compensate for the absence of F103 and M106, presumably by stabilizing the NS1A-CPSF30 complex...
  101. ncbi IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 172:7603-9. 2004
    ..This increased susceptibility to secondary bacterial pneumonia is at least in part caused by excessive IL-10 production and reduced neutrophil function in the lungs...

Research Grants72

  1. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  2. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  3. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  4. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  5. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  6. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
    ..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. [unreadable] [unreadable]..
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  8. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  9. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
    ..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
  10. Novel broad spectrum vaccination against influenza
    Petr Ilyinskii; Fiscal Year: 2006
    ..The overall aim of this project is to demonstrate better protective effect or/and enhanced immune response using modified influenza proteins as immunogens compared to wild-type viral proteins. ..
  11. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2002
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  12. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
    ....
  13. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2001
    ....
  14. Modification of Conserved Influenza Genes Enabling their Elevated Expression
    Petr Ilyinskii; Fiscal Year: 2008
    ..Therefore, if proven, our approach will lead to a novel paradigm for recombinant gene modifications for enhanced expression in vivo, both for vaccine and non-vaccine applications. [unreadable] [unreadable] [unreadable]..
  15. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
    ....
  16. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2007
    ..abstract_text> ..
  17. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  18. Host range restriction of human influenza viruses
    Christopher Olsen; Fiscal Year: 2009
    ..abstract_text> ..
  19. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  20. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  21. Dissecting 3 processing pathways that generate class II-restricted flu epitopes
    Laurence Eisenlohr; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. IMPACT OF EPITOPE DENSITY ON TCD8, ACTIVATION AND MEMORY
    Laurence Eisenlohr; Fiscal Year: 2003
    ..He believes that the pursuit of these aims will provide fundamentally important information about TCD8+-mediated immunity and will put us in a strong position to address the next generation of questions that will be facing the field. ..
  23. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
    ..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
  24. Accelerated Viral Inhibition Assay
    Maryna Eichelberger; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
  26. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  27. Class II Processing Delineated by Flu Glycoproteins
    Laurence Eisenlohr; Fiscal Year: 2008
    ..abstract_text> ..
  28. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  29. The Role of the RET Receptor in Autoimmune Disease
    Laurence Eisenlohr; Fiscal Year: 2007
    ..By deciphering the role of RETECD antibody in disease, we can design improved methods and drugs for the abrogation of thyroid and other organ-specific autoimmune disorders. [unreadable] [unreadable] [unreadable]..
  30. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  31. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  32. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  33. The Basis for MHC Class II-restricted proteasome-dependent epitopes
    LAURENCE CRANE EISENLOHR; Fiscal Year: 2010
    ..Execution of the plan could fundamentally alter the general perception of CD4+ T cell responses and the roles they play in protection, thereby strongly influencing the design of future vaccines. ..
  34. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  35. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  36. Recruitment of memory CD8+ T cells to the lung airways
    JACOB KOHLMEIER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. Lymphocyte Exit from Tissues: Control and Significance to Host Defense
    GUDRUN DEBES; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Lassa and Nipah Virus Interferon-Antagonists
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..abstract_text> ..
  39. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  40. INITIATION OF VIRUS SPECIFIC CD8+ T CELL RESPONSES
    Maryna Eichelberger; Fiscal Year: 2002
    ..This proposal is designed as an essential step towards the development of more effective influenza vaccine. ..
  41. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  42. EBOLA VIRUS INTERFERON-ANTAGONISTS AND VIRULENCE
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..VP35 and VP24 may also prove to be attractive targets for new antiviral agents. Inhibition of anti-IFN factors may sensitize Ebola virus infected cells to the antiviral effects of IFN and may also enhance the effect of antiviral agents. ..
  43. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
  44. Lethality of H5N1 Influenza Virus is Linked to TGF-beta
    Stacey Schultz Cherry; Fiscal Year: 2009
    ..These studies provide a unique opportunity to understand the cellular and immunological basis of H5N1 influenza virus virulence in mammals: currently, an unexplored area of investigation. ..
  45. Encapsidation of Adenovirus DNA
    Michael J Imperiale; Fiscal Year: 2010
    ..This knowledge will be applicable to the development of anti-viral drugs that block this process, as well as to the development of safer adenovirus vectors and recombinant vaccines. ..
  46. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter C Doherty; Fiscal Year: 2010
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
  47. MOLECULAR MECHANISMS OF INFLUENZA PANDEMICS
    Yoshihiro Kawaoka; Fiscal Year: 2008
    ..Collectively, these studies will help to elucidate the mechanism(s) underlying the emergence of new (pandemic) influenza A virus lineages, a crucial step in combating future threats from this virus. [unreadable] [unreadable] [unreadable]..
  48. Molecular Pathogenesis of Ebolavirus Infection
    Yoshihiro Kawaoka; Fiscal Year: 2010
    ..By advancing knowledge of likely determinants of Ebolavirus pathogenicity, we expect to provide compelling new rationales for vaccine and targeted drug development. ..
  49. INFLUENZA VIRUS ASSEMBLY
    Yoshihiro Kawaoka; Fiscal Year: 2009
    ..abstract_text> ..
  50. Innate Immunity to Influenza in Caloric Restricted Aged Mice
    Elizabeth Gardner; Fiscal Year: 2007
    ..CR mice will be fed AL diets to restore weight to 50% and 100% of AL mice before infection with influenza and outcomes in Specific Aims 1 and 2 will be assessed. [unreadable] [unreadable] [unreadable]..
  51. TRANSFECTANT INFLUENZA VIRUSES IN CANCER THERAPY
    Adolfo Garcia Sastre; Fiscal Year: 2002
    ..The proposed research may advance the field of cancer therapy towards possible novel ways to treat human tumors and prolong survival of cancer patients. ..
  52. Vulnerability to Smallpox Due to Declining CTL Immunity
    Innocent Mbawuike; Fiscal Year: 2003
    ..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
  53. Molecular Basis for Ebola Virus Pathogenicity
    Yoshihiro Kawaoka; Fiscal Year: 2007
    ..Ultimately, the information gained could be exploited in the development of antiviral compounds and effective vaccines. ..
  54. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2007
    ..abstract_text> ..
  55. ARSENIC, OXIDATIVE STRESS, AND TRANSCRIPTIONAL CONTROL
    Miroslav Styblo; Fiscal Year: 2002
    ....
  56. Mechanism of Arsenic-Induced Diabetes
    Miroslav Styblo; Fiscal Year: 2002
    ....
  57. Pathogenesis of Infectious in Swine with Pathogenic Avian Influenza Viruses
    BH JANKE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. MECHANISM OF DIFFERENTIATION OF FUNCTION OF CD80 & CD86
    MICHAEL AGADJANYAN; Fiscal Year: 2004
    ..5). The differential expression of genes after ligation of CD86 versus CD80 on muscle cells and professional APC. ..
  59. Exercise & influenza immunity:Psychoneuroendocrine Model
    Marian Kohut; Fiscal Year: 2004
    ..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
  60. Antigen-specific CD4+ T cell responses to influenza
    Paul Thomas; Fiscal Year: 2007
    ..Finally, the effects of antigen-specific vs. unrelated antigen priming by influenza on allergic responses on different genetic backgrounds will be examined. ..
  61. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2003
    ..Such a model would facilitate a thorough understanding of the regulation of the immune response to TSHR with implications for the development of novel therapeutics. ..
  62. Microarray Analysis of Translational Regulatory Pathways
    Michael Katze; Fiscal Year: 2003
    ..The proposed studies make use of technologies not available at the time of the parent grant award and will allow us to capitalize on recent findings and extend our studies in new directions. ..
  63. XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXES
    Ian Wilson; Fiscal Year: 2001
    ..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..
  64. HEPATITIS C VIRUS AND INTERFERON--CONTROL OF PKR BY NS5A
    Michael Katze; Fiscal Year: 2001
    ..3) Identification of NS5A phosphorylation sites in vivo. The importance of such sites for NS5A function will be examined by site-directed mutagenesis. ..
  65. Induction of tolerance to islet cell transplants
    Bellur Prabhakar; Fiscal Year: 2004
    ..Under aim 3: we will prepare a new BiAb using an islet cell specific antibody and anti-CTLA-4 antibody to test ability to prevent and treat Type I DM in a murine model of spontaneous diabetes. ..
  66. X-ray structures of HIV-1 neutralizing sites
    Ian Wilson; Fiscal Year: 2008
    ..These studies all have the common goal of providing essential structural information on HIV-1 proteins and anti-HIV-1 antibodies to help guide efforts in vaccine and inhibitor design. [unreadable] [unreadable]..
  67. HEPATITIS C VIRUS:PATHOGENESIS AND CELLULAR SIGNALING
    Michael Katze; Fiscal Year: 2005
    ..Identification of the kinase will likely help decipher the detailed molecular pathways uncovered from these studies. These studies may contribute to the identification of novel cellular gene targets for anti-HCV therapeutics. ..
  68. GENE EXPRESSION PROFILING OF AIDS VACCINE STRATEGIES
    Michael Katze; Fiscal Year: 2007
    ..Ultimately, these studies may also suggest mechanisms to enhance current AIDS vaccine strategies. [unreadable] [unreadable] [unreadable]..
  69. TRANSLATIONAL CONTROL IN INFLUENZA VIRUS INFECTED CELLS
    Michael Katze; Fiscal Year: 2009
    ..The identification of host pathways impacted by influenza virus should reveal novel therapeutic targets and lead to improved antiviral therapies and vaccines. ..
  70. Becton Dickinson Flow Cytometry System
    Bellur Prabhakar; Fiscal Year: 2002
    ..Careful evaluation of the three available systems prompted our users group to recommend the BD FACS Vantage SE since it would satisfy the needs of our institution's NIH-funded investigators. ..
  71. Novel human gene-IG20-potential role in cancer therapy
    Bellur Prabhakar; Fiscal Year: 2009
    ..These studies will lead to a clearer understanding of the mechanism of action of IG20/DENN-SV in ovarian cancer. ..