respirovirus infections

Summary

Summary: Infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.

Top Publications

  1. ncbi Current status of vaccines for parainfluenza virus infections
    Masatoki Sato
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Pediatr Infect Dis J 27:S123-5. 2008
  2. ncbi Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 122:669-82. 2005
  3. pmc The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
  4. ncbi Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization
    Geoffrey A Weinberg
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Pediatr 154:694-9. 2009
  5. pmc Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy
    Crystal W Burke
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002134. 2011
  6. ncbi Human parainfluenza virus-associated hospitalizations among children less than five years of age in the United States
    M E Counihan
    Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Pediatr Infect Dis J 20:646-53. 2001
  7. ncbi A cotton rat model of human parainfluenza 3 laryngotracheitis: virus growth, pathology, and therapy
    Martin G Ottolini
    Department of Pediatrics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland 20814 4799, USA
    J Infect Dis 186:1713-7. 2002
  8. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
  9. ncbi Human parainfluenza virus type I (HPIV1) vaccine candidates designed by reverse genetics are attenuated and efficacious in African green monkeys
    Emmalene J Bartlett
    Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6511, 50 South Drive MSC 8007, Bethesda, MD 20892 8007, USA
    Vaccine 23:4631-46. 2005
  10. pmc Molecular epidemiology of two consecutive outbreaks of parainfluenza 3 in a bone marrow transplant unit
    M Zambon
    Enteric and Respiratory Virus Laboratory, Central Public Health Laboratory, London, United Kingdom
    J Clin Microbiol 36:2289-93. 1998

Research Grants

  1. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
  2. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2001
  3. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2007
  4. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
  5. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
  6. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2002
  7. Role of ephrins in lung edema due to virus and hypoxia
    Todd Carpenter; Fiscal Year: 2008
  8. EFFECT OF VIRUS AND HYPOXIA ON LUNG ENDOTHELIN AND EDEMA
    Todd Carpenter; Fiscal Year: 2004
  9. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
  10. INTERACTION OF PARAINFLUENZA 3 WITH THE HOST CELL
    Maria Arantxa Horga; Fiscal Year: 2004

Detail Information

Publications148 found, 100 shown here

  1. ncbi Current status of vaccines for parainfluenza virus infections
    Masatoki Sato
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Pediatr Infect Dis J 27:S123-5. 2008
    ..These promising candidates deserve to enter into efficacy trials both for their ability to prevent PIV3 disease and as a model of protection against respiratory illness by mucosal vaccination...
  2. ncbi Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 122:669-82. 2005
    ..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
  3. pmc The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae
    Irina V Alymova
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Antimicrob Agents Chemother 49:398-405. 2005
    ..Prophylaxis of parainfluenza virus infections with antivirals might be an effective strategy for prevention of secondary bacterial complications in humans...
  4. ncbi Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization
    Geoffrey A Weinberg
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Pediatr 154:694-9. 2009
    ..To determine the population-based inpatient disease burden of parainfluenza virus in children <5 years of age...
  5. pmc Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy
    Crystal W Burke
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002134. 2011
    ..Overall, these results reveal a dichotomy between PIV infection in the URT and trachea versus the lungs and define a new model for studies of pathogenesis, development of live virus vaccines, and testing of antiviral therapies...
  6. ncbi Human parainfluenza virus-associated hospitalizations among children less than five years of age in the United States
    M E Counihan
    Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Pediatr Infect Dis J 20:646-53. 2001
    ..More precise estimates of HPIV-associated hospitalizations would require large prospective studies of HPIV-associated diseases by more sensitive viral testing methods, such as polymerase chain reaction techniques...
  7. ncbi A cotton rat model of human parainfluenza 3 laryngotracheitis: virus growth, pathology, and therapy
    Martin G Ottolini
    Department of Pediatrics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland 20814 4799, USA
    J Infect Dis 186:1713-7. 2002
    ..Topical glucocorticoid therapy, with or without concurrent topical immunotherapy with antibody to PIV3, did not lead to a rebound of viral replication...
  8. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
    ....
  9. ncbi Human parainfluenza virus type I (HPIV1) vaccine candidates designed by reverse genetics are attenuated and efficacious in African green monkeys
    Emmalene J Bartlett
    Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6511, 50 South Drive MSC 8007, Bethesda, MD 20892 8007, USA
    Vaccine 23:4631-46. 2005
    ..One genetically and phenotypically stable vaccine candidate, rC(R84G/F170S)L(Y942A/L992C), was attenuated and efficacious in AGMs and is a promising live attenuated intranasal HPIV1 vaccine candidate suitable for clinical evaluation...
  10. pmc Molecular epidemiology of two consecutive outbreaks of parainfluenza 3 in a bone marrow transplant unit
    M Zambon
    Enteric and Respiratory Virus Laboratory, Central Public Health Laboratory, London, United Kingdom
    J Clin Microbiol 36:2289-93. 1998
    ..These data indicate that introduction of community parainfluenza 3 strains to the bone marrow transplant unit was followed by person-to-person transmission within the unit rather than reintroduction of virus from the community...
  11. ncbi Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells
    Karin Fink
    Centre Hospitalier de l Université de Montréal Research Center St Luc Hospital and Institut National de la Santé et de la Recherche Médicale Unité 743, Montreal, Quebec, Canada
    J Immunol 180:6911-22. 2008
    ..These results illustrate a previously unrecognized dual role of NOX2 in the regulation of NF-kappaB in response to RSV and Sendai virus in human AEC...
  12. pmc Interleukin 12 p40 production by barrier epithelial cells during airway inflammation
    M J Walter
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Exp Med 193:339-51. 2001
    ..Taken together, these results suggest a novel role for epithelial-derived IL-12 p40 in modifying the level of airway inflammation during mucosal defense and disease...
  13. pmc Parainfluenza viruses
    Kelly J Henrickson
    Department of Pediatrics Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Microbiol Rev 16:242-64. 2003
    ..HPIV are closely related to recently discovered megamyxoviruses (Hendra and Nipah viruses) and metapneumovirus...
  14. ncbi Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype
    Linda S Cauley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:6655-8. 2002
    ..Differences in CD25 and CD11a expression indicate that the CD4(+) cells from the lung airways and parenchyma are distinct memory populations...
  15. ncbi Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population
    K J Cortez
    Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 184:1093-7. 2001
    ..A chain of transmission within the outpatient clinic appeared to have occurred in 4 outpatients and to have extended to 2 hospitalized patients. Molecular epidemiology was useful in discerning routes of transmission in this outbreak...
  16. pmc IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection
    Sean Gunsten
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunology 126:500-13. 2009
    ....
  17. ncbi IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1
    Tonya D Russell
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 171:6866-74. 2003
    ..Thus, Rbeta1 mediates p80-dependent macrophage chemotaxis and inhibition of the p80-Rbeta1 interaction may provide a novel anti-inflammatory strategy to manipulate the inflammation associated with asthma and respiratory viral infection...
  18. pmc Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections
    Xiaoyan Zhan
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    Vaccine 26:3480-8. 2008
    ..Results encourage the continued development of the candidate recombinant SeV vaccines to combat serious respiratory infections of children...
  19. ncbi Isolation and genetic characterization of bovine parainfluenza virus type 3 from cattle in China
    Yuan Mao Zhu
    Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, No 427 Maduan Street, Nan Gang District, Harbin 150001, Heilongjiang Province, PR China
    Vet Microbiol 149:446-51. 2011
    ..This is the first study to report the isolation and genetic characterization of BPIV3 from cattle in China...
  20. pmc Generation of recombinant human parainfluenza virus type 1 vaccine candidates by importation of temperature-sensitive and attenuating mutations from heterologous paramyxoviruses
    Jason T Newman
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:2017-28. 2004
    ..Thus, importation of attenuating mutations from heterologous viruses is an effective means for rapidly identifying mutations that attenuate HPIV1 and for generating live-attenuated HPIV1 vaccine candidates...
  21. pmc Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungs
    R J Hogan
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 193:981-6. 2001
    ..Taken together, these data demonstrate that activated memory CD4(+) T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity...
  22. ncbi Safety and immunogenicity of intranasal murine parainfluenza virus type 1 (Sendai virus) in healthy human adults
    Karen S Slobod
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Vaccine 22:3182-6. 2004
    ..Results encourage future trials to evaluate the efficacy of Sendai virus in preventing human PIV-1 infection in infants and children...
  23. ncbi Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1
    Cao Qi Lei
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Immunity 33:878-89. 2010
    ..Our findings suggest that GSK3β plays important roles in virus-triggered IRF3 activation by promoting TBK1 activation and provide new insights to the molecular mechanisms of cellular antiviral response...
  24. pmc Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection
    Antonina M Akk
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 180:3535-42. 2008
    ..These results indicate that DPPI and neutrophils play a critical role in Sendai virus-induced asthma phenotype as a result of a DPPI-dependent neutrophil recruitment and cytokine response...
  25. ncbi Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment
    Tatiana Bousse
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, NY 14642, USA
    Virus Res 121:23-32. 2006
    ..These results suggest that SeV is less effective than hPIV1 in overcoming antiviral activity in human cells, which could be one of the factors that restrict the host range of SeV...
  26. pmc The long noncoding region of the human parainfluenza virus type 1 f gene contributes to the read-through transcription at the m-f gene junction
    Tatiana Bousse
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:8244-51. 2002
    ..These phenotypes seem to be responsible for the extended survival of mice infected with rSVhMFjCG...
  27. pmc Antiviral instruction of bone marrow leukocytes during respiratory viral infections
    Tamar Hermesh
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Host Microbe 7:343-53. 2010
    ..These findings show that appropriate instruction of cells during their development in the bone marrow is needed for effective control of infection...
  28. pmc IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence
    Kristi Peters
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Virol 82:3500-8. 2008
    ..These results demonstrated that in our model system, IRF-3 controlled the fate of the SeV-infected cells by promoting apoptosis and preventing persistence...
  29. ncbi Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes
    Hiroto Matsuse
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Int Arch Allergy Immunol 138:267-72. 2005
    ..Viral respiratory tract infections represent the most frequent cause of asthma exacerbation in both children and adults, but the precise mechanism of such exacerbation remains unknown...
  30. ncbi Cellular immunity and memory to respiratory virus infections
    D L Woodland
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Res 24:53-67. 2001
    ..A thorough understanding of the cellular immune response to infection in the lungs is essential for future vaccine development...
  31. pmc Viral induction of a chronic asthma phenotype and genetic segregation from the acute response
    Michael J Walter
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 110:165-75. 2002
    ..These two phenotypes can be segregated by their dependence on the ICAM-1 gene and so depend on distinct controls that appear critical for the development of lifelong airway diseases such as asthma...
  32. pmc Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity
    M Itoh
    Department of Microbiology, Kobe University School of Medicine, Japan
    J Virol 72:2927-34. 1998
    ..The C protein was shown to have the capacity to induce apoptosis, and the increased level of the C protein in MVC11-infected cells was considered to account partly, if not entirely, for the induction of apoptosis...
  33. ncbi Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate
    Takemasa Sakaguchi
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Virology 313:581-7. 2003
    ..The V protein therefore seems to be potentially functional in the highly virulent Hamamatsu strain and to be prominent if virus replication is restricted...
  34. pmc Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 81:3264-71. 2007
    ..Conversely, the results show that the innate immunity contributed to elimination of SeV in early stages of infection in the absence of anti-IFN capacity...
  35. pmc Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Virol 79:12944-51. 2005
    ..Therefore, there appears to be a large degree of cell-type specificity in the mechanisms used by the host to recognize infecting viruses...
  36. ncbi Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees
    Mario H Skiadopoulos
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 297:153-60. 2002
    ..Its ability to efficiently replicate in nonhuman primates suggests that MPIV1 lacks a significant host range restriction in primates and could theoretically cause zoonotic disease in humans...
  37. pmc Robust IgA and IgG-producing antibody forming cells in the diffuse-NALT and lungs of Sendai virus-vaccinated cotton rats associate with rapid protection against human parainfluenza virus-type 1
    R Sealy
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Vaccine 28:6749-56. 2010
    ....
  38. pmc Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA
    Yutaka Fujii
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Virol 76:8540-7. 2002
    ..These findings suggest that leader mutations of SeV affect virus pathogenesis by altering virus replication in a host-dependent manner...
  39. pmc Residues in the heptad repeat a region of the fusion protein modulate the virulence of Sendai virus in mice
    Laura E Luque
    Division of Virology, Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Virol 84:810-21. 2010
    ..An understanding of how the F protein contributes to infection and inflammation in vivo may assist in the development of antiviral therapies against respiratory paramyxoviruses...
  40. pmc Detection and identification of human parainfluenza viruses 1, 2, 3, and 4 in clinical samples of pediatric patients by multiplex reverse transcription-PCR
    J C Aguilar
    Servicio de Virologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera de Majadahonda Pozuelo s n, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 38:1191-5. 2000
    ..Also, HPIV-4 was more frequently detected than HPIV-2 in this study, suggesting that it may have been underestimated as a lower respiratory tract pathogen because of the insensitivity of cell culture...
  41. ncbi Differential invasion by Sendai virus of abdominal parenchymal organs and brain tissues in cortisone- and cyclophosphamide-based immunosuppressed mice
    Takeo Miyamae
    School of Health Sciences, Fujita Health University, Toyoake, Aichi, Japan
    J Vet Med Sci 67:369-77. 2005
    ..Blood-brain barrier disruption was caused by virulence of the MN strain. Half the infected mice in two groups treated with CO once and CY twice succumbed to delayed hypersensitivity, suggested by cerebro-microvascular nodulation...
  42. pmc Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4
    Kate E Templeton
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1564-9. 2004
    ..In addition, results can be obtained within 6 h, which increases clinical relevance. Therefore, use of this real-time PCR assay would improve patient management and infection control...
  43. pmc Cytopathogenesis of Sendai virus in well-differentiated primary pediatric bronchial epithelial cells
    Remi Villenave
    Queen s University Belfast, Medical Biology Centre, Belfast BT9 7BL, Northern Ireland
    J Virol 84:11718-28. 2010
    ..Alternatively, such robust responses might constitute appropriate normal host responses to viral infection and be a prerequisite for the induction of efficient immune responses...
  44. ncbi Identification of two distinct bovine parainfluenza virus type 3 genotypes
    Paul Francis Horwood
    Department of Primary Industries and Fisheries, Ritchie Building 64A, Level 3, C Wing, Research Road, St Lucia, QLD 4072, Australia
    J Gen Virol 89:1643-8. 2008
    ..These newly identified genotypes have implications for the development of BPIV-3 molecular detection methods and may also impact on BPIV-3 vaccine formulations...
  45. ncbi Attenuation of a field Sendai virus isolate through egg-passages is associated with an impediment of viral genome replication in mouse respiratory cells
    K Kiyotani
    Department of Bacteriology, Hiroshima University School of Medicine, Japan
    Arch Virol 146:893-908. 2001
    ....
  46. ncbi A live human parainfluenza type 3 virus vaccine is attenuated and immunogenic in young infants
    Ruth A Karron
    Pediatr Infect Dis J 22:394-405. 2003
    ..Parainfluenza type 3 virus (PIV-3) infections cause lower respiratory tract illness in children throughout the world. A licensed PIV-3 vaccine is not yet available...
  47. ncbi Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada
    FEBS J 272:3120-31. 2005
    ..These results show for the first time that the ArgII gene is an early IRF-3-regulated gene, which participates in the IFN-independent antiviral response through polyamine production and induction of apoptosis...
  48. ncbi Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection
    Laurie P Shornick
    Department of Biology and Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO 63103, USA
    J Immunol 180:3319-28. 2008
    ..These findings provide some of the most definitive evidence to date for the critical role of barrier epithelial cells in innate immunity to common pathogens, particularly in controlling viral replication...
  49. ncbi MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles
    Jacob S Yount
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:4910-8. 2008
    ..The unique mechanism by which DI particles trigger the maturation of DCs represents a novel strategy that could be further exploited for the development of potent adjuvant molecules...
  50. ncbi TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses
    CAROLINA B LOPEZ
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 173:6882-9. 2004
    ..The revelation of this pathway should stimulate invigorating research into the mechanism for virus-induced DC maturation and immunity...
  51. pmc Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary function
    D C Look
    Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Pathol 159:2055-69. 2001
    ..Taken together, these model systems of paramyxoviral respiratory infection mimic human pathology and identify epithelial cell Foxj1 expression as an early marker of epithelial cell differentiation, recovery, and function...
  52. ncbi Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III
    Michael C Lawrence
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, VIC 3052, Australia
    J Mol Biol 335:1343-57. 2004
    ..However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface...
  53. pmc Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease
    Anne Moscona
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Invest 115:1688-98. 2005
    ..There are several steps during the process of binding, triggering, and fusion that are now understood at the molecular level, and each of these steps represents potential targets for interrupting infection...
  54. ncbi Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains
    Pedro Faisca
    Department of Pathology, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    Am J Physiol Lung Cell Mol Physiol 289:L777-87. 2005
    ..The results unambiguously suggest that BALB/c (resistant) and 129Sv (susceptible) strains should be used in crossing experiments aimed at identifying the genes involved in resistance to Paramyxoviridae by the positional cloning approach...
  55. ncbi Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections
    R J Hogan
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 166:1813-22. 2001
    ..The kinetics of persistence of Ag-specific CD8(+) T cells in the lung suggests that they play a key role in protective cellular immunity to respiratory virus infections...
  56. ncbi Cutting edge: effector memory CD8+ T cells play a prominent role in recall responses to secondary viral infection in the lung
    Alan D Roberts
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 172:6533-7. 2004
    ..These data contrast with other studies indicating that central memory CD8(+) T cells are the prominent contributors to systemic virus infections...
  57. ncbi Multigenic control of resistance to Sendai virus infection in mice
    A Y Simon
    Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Infect Genet Evol 9:1253-9. 2009
    ..These findings revealed a novel gene interactions controlling SeV resistance in mice and will enable the identification of resistance genes encoded within these loci...
  58. ncbi Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
    M G Wathelet
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell 1:507-18. 1998
    ..These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo...
  59. pmc Phenotypes and functions of persistent Sendai virus-induced antibody forming cells and CD8+ T cells in diffuse nasal-associated lymphoid tissue typify lymphocyte responses of the gut
    Rajeev Rudraraju
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Virology 410:429-36. 2011
    ..Phenotypic analyses of virus-specific T cells revealed striking similarities with pathogen-specific immune responses in the intestine, highlighting some key features of adaptive immunity at a mucosal site...
  60. pmc Molecular investigations of an outbreak of parainfluenza virus type 3 and respiratory syncytial virus infections in a hematology unit
    Hamid Jalal
    Centre for Virology, Department of Infection, Royal Free and University College Medical School UCL Campus, Windeyer Institute of Medical Sciences, London W1T 4JF, United Kingdom
    J Clin Microbiol 45:1690-6. 2007
    ....
  61. pmc Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro
    Josephine M McAuliffe
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:2029-36. 2004
    ..These findings identify the use of alternative codon substitution mutations as a method that can be used to generate candidate vaccine viruses with increased genetic stability and/or a modified level of attenuation...
  62. ncbi Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice
    Katsuhiro Kiyotani
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Virology 359:82-91. 2007
    ..These results indicate that SeV V protein counteracts IRF-3-mediated innate antiviral immunity for efficient virus replication and pathogenesis in mice, but it is not IFN...
  63. ncbi Cutting edge: effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 171:3338-42. 2003
    ..These data demonstrate that lung airway memory CD8(+) T cells are not terminally differentiated cells and retain the capacity to mediate recall responses to infection...
  64. ncbi [Diagnostic tests: Parainfluenza virus 1, 2, 3, 4]
    Satoshi Iwata
    Department of Pediatrics, National Hospital Organization Tokyo Medical Center
    Nihon Rinsho 63:349-51. 2005
  65. ncbi Medical burden of respiratory syncytial virus and parainfluenza virus type 3 infection among US children. Implications for design of vaccine trials
    Min Shi Lee
    MedImmune Vaccines Inc, Mountain View, California, USA
    Hum Vaccin 1:6-11. 2005
    ..Since age-specific rates of RSV and PIV3-related LRI can vary significantly in different populations, collecting age-specific LRI rates in phase 1 and 2 trials to further understand this variability appears warranted...
  66. ncbi Synthesis of recombinant human parainfluenza virus 1 and 3 nucleocapsid proteins in yeast Saccharomyces cerevisiae
    Mindaugas Juozapaitis
    Institute of Biotechnology, V A Graiciuno 8, Vilnius LT 02241, Lithuania
    Virus Res 133:178-86. 2008
    ..When used as coating antigens in an indirect ELISA, the recombinant N proteins reacted with sera of patients infected with HPIV1 or 3. Serological assays to detect HPIV-specific antibodies could be designed on this basis...
  67. ncbi Role of airway epithelial injury in murine orthotopic tracheal allograft rejection
    Elbert Kuo
    Department of Surgery, Washington University, St Louis, Missouri 63110, USA
    Ann Thorac Surg 82:1226-33. 2006
    ..The purpose of this study was to determine whether (1) orthotopic tracheal transplantation showed signs of allograft rejection, and (2) airway epithelial cell injury promoted orthotopic tracheal allograft rejection...
  68. pmc Human parainfluenza viruses hPIV1 and hPIV3 bind oligosaccharides with alpha2-3-linked sialic acids that are distinct from those bound by H5 avian influenza virus hemagglutinin
    Mary Amonsen
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    J Virol 81:8341-5. 2007
    ..While the receptor is not the sole determinant of tropism, hPIV or H5 influenza virus infection of specific cells that express receptors may contribute to their different pathologies...
  69. ncbi Invited commentary
    Niels P van der Kaaij
    Department of Cardiothoracic Surgery, Room Ee 173, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE The Netherlands
    Ann Thorac Surg 82:1050-1. 2006
  70. ncbi Controls for lung dendritic cell maturation and migration during respiratory viral infection
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:1438-48. 2007
    ..Our results indicate that pDCs and cDCs respond distinctly to respiratory paramyxoviral infection with patterns of movement that should serve to coordinate the innate and adaptive immune responses, respectively...
  71. ncbi Newly-developed Sendai virus vector for retinal gene transfer: reduction of innate immune response via deletion of all envelope-related genes
    Yusuke Murakami
    Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gene Med 10:165-76. 2008
    ..We recently developed a novel rSeV from which all envelope-related genes were deleted (rSeV/dFdMdHN) and, in the present study, assess host immune responses following retinal gene transfer...
  72. ncbi [Clinical and epidemiological manifestations of parainfluenza infection in hospitalized children]
    Luis E Vega-Briceño
    Departamento de Pediatria, Pontificia Universidad Católica de ChileSantiago, Chile
    Rev Chilena Infectol 24:377-83. 2007
    ..Human parainfluenza viruses (hPIV) are a common cause of respiratory illness of children but published data on clinical characteristics of hPIV infection in South America is scarce...
  73. ncbi Optimisation of the response to respiratory virus vaccines in cattle
    R G O'Neill
    University of Glasgow Veterinary School, Glasgow G61 1QH
    Vet Rec 161:269-70. 2007
  74. ncbi Memory T cell populations in the lung airways are maintained by continual recruitment
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 176:537-43. 2006
    ..These data indicate that peripheral T cell memory is dynamic and depends on a systemic source of T cells...
  75. ncbi Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:3535-42. 2007
    ..These data suggest that memory T cell pools become progressively dysregulated over time and this may have a significant impact on immune responsiveness in the aged...
  76. ncbi CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
    Jeffrey W Tyner
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:1180-7. 2005
    ..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process...
  77. ncbi Respiratory viral infection in obliterative airway disease after orthotopic tracheal transplantation
    Elbert Kuo
    Department of Surgery, Washington University, St Louis, Missouri 63110, USA
    Ann Thorac Surg 82:1043-50. 2006
    ..The goal of this study was to investigate the role of respiratory viral infections in chronic lung allograft rejection using the murine orthotopic tracheal transplantation model...
  78. ncbi Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children
    Robert B Belshe
    Saint Louis University, St Louis, Missouri 63110, USA
    J Infect Dis 190:2096-103. 2004
    ..Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/PV3 vaccine is feasible for simultaneous administration, and further studies are warranted...
  79. ncbi Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury
    Xuezhong Cai
    Department of Pathobiology, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1263-9. 2003
    ..IP-10 early high expression might contribute to the resistance to virus-induced airway disease in F344 rats by promoting Th1 responses and increasing antiviral activity...
  80. pmc Mucosal immunization of rhesus monkeys against respiratory syncytial virus subgroups A and B and human parainfluenza virus type 3 by using a live cDNA-derived vaccine based on a host range-attenuated bovine parainfluenza virus type 3 vector backbone
    Alexander C Schmidt
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:1089-99. 2002
    ....
  81. ncbi Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs
    Michael J Carr
    The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 165:1071-5. 2002
    ....
  82. ncbi Renewal of peripheral CD8+ memory T cells during secondary viral infection of antibody-sufficient mice
    Linda S Cauley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 170:5597-606. 2003
    ..These studies provide important new insight into mechanisms that control the maintenance and renewal of peripheral memory T cell populations during natural infections...
  83. ncbi Identification of ectopic anionic trypsin I in rat lungs potentiating pneumotropic virus infectivity and increased enzyme level after virus infection
    Takae Towatari
    Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Japan
    Eur J Biochem 269:2613-21. 2002
    ..These results suggest that ectopic anionic trypsin I in rat lungs induced by virus infection may trigger virus spread in rat lungs...
  84. ncbi Dexamethasone prevents virus-induced hyperresponsiveness via multiple mechanisms
    Liliana Moreno
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 285:L451-5. 2003
    ..This high-dose dexamethasone also increased M2 receptor function in uninfected animals. In conclusion, dexamethasone prevented virus-induced hyperresponsiveness and M2 receptor dysfunction via multiple mechanisms...
  85. ncbi Influence of maternal immunity on antibody and T-cell response in mice
    Gunilla A M Blomqvist
    Department of Virology, National Veterinary Institute, BMC, P O Box 585, S 751 23 Uppsala, Sweden
    Vaccine 21:2022-31. 2003
    ....
  86. ncbi Primary replication of a recombinant Sendai virus vector in macaques
    Munehide Kano
    AIDS Research Centre, Department of Viral Diseases and Vaccine Control, Division of Experimental Animal Research, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Gen Virol 83:1377-86. 2002
    ..None of the SeV-immunized macaques displayed appreciable clinical manifestations. These results support the idea that this system may be used safely in primates, including humans...
  87. ncbi Long-term maintenance of virus-specific effector memory CD8+ T cells in the lung airways depends on proliferation
    Robert J Hogan
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:4976-81. 2002
    ..These data have significant implications for vaccines designed to promote cellular immunity at mucosal sites such as the lung...
  88. ncbi Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma
    Robin Stephens
    Center for Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:5458-67. 2002
    ..This implies that circulating Th2 cells in allergic individuals could enter the lungs in response to infection or inflammation and become activated to trigger allergy...
  89. ncbi Increased IFN-gamma protein in bronchoalveolar lavage fluid of anti-IP-10 antibody-treated F344 rats following Sendai viral infection
    Xuezhong Cai
    Department of Pathobiology, University of Florida, Gainesville, FL 32611 0880, USA
    J Interferon Cytokine Res 22:1175-9. 2002
    ..This interesting phenomenon suggests that expression of IFN-gamma protein can be modulated by treatment with anti-IP-10 antibody at the posttranscriptional or translational level in this model...
  90. ncbi Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Internal Medicine, Room G2 130, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Immunol Lett 89:201-6. 2003
    ..In spite of the structural similarities shared by the F proteins of Sendai virus and RSV, TLR4 is not involved in host defense against respiratory tract infection with Sendai virus...
  91. ncbi IL-12 reduces the severity of Sendai virus-induced bronchiolar inflammation and remodeling
    Amy E S Stone
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, USA
    Cytokine 24:103-13. 2003
    ....
  92. ncbi Bovine parainfluenza virus type 3 (PIV3) expressing the respiratory syncytial virus (RSV) attachment and fusion proteins protects hamsters from challenge with human PIV3 and RSV
    Aurelia A Haller
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 84:2153-62. 2003
    ..Such a vaccine would vastly reduce the respiratory disease burden, the associated hospitalization costs and, most importantly, decrease morbidity and mortality of infants, immunocompromised individuals and the elderly...
  93. ncbi Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 170:1423-9. 2003
    ..Together, these data suggest that inflammation can accelerate memory T cell migration to nonlymphoid tissues and is a part of the normal recall response during respiratory infections...
  94. ncbi Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 172:5450-5. 2004
    ..In summary, these data suggest that LAG-3 negatively regulates T cell expansion and controls the size of the memory T cell pool...
  95. ncbi Phase 2 evaluation of parainfluenza type 3 cold passage mutant 45 live attenuated vaccine in healthy children 6-18 months old
    Robert B Belshe
    Division of Infectious Diseases and Immunology, Saint Louis University, St Louis, Missouri, USA
    J Infect Dis 189:462-70. 2004
    ..PIV3-cp45 vaccine was safe and immunogenic in seronegative children and should be evaluated for efficacy in a phase 3 field trial...
  96. ncbi Parainfluenza virus 3 infection pre- and post-haematopoietic stem cell transplantation: re-infection or persistence?
    K E Templeton
    Departments of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands
    J Clin Virol 29:320-2. 2004
    ..A 5-year-old boy with acute lymphoblastic leukaemia (ALL) received a haematopoietic stem cell transplant (HSCT) from his father and was monitored for the presence of respiratory viruses...
  97. ncbi MIP-T3 is a negative regulator of innate type I IFN response
    Ming Him James Ng
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Immunol 187:6473-82. 2011
    ..Our findings suggest that MIP-T3 functions as a negative regulator of innate IFN response by preventing TRAF3 from forming protein complexes with critical downstream transducers and effectors...
  98. ncbi Salmonella expressing a T-cell epitope from Sendai virus are able to induce anti-infection immunity
    He Huang
    Laboratory for Immunology and Microbiology, BioMedical Education Center, Peking University Health Science Center, Beijing, PR China
    J Med Microbiol 58:1236-42. 2009
    ..The Salmonella fimbrial display system efficiently induces a cellular immune response and anti-infection immunity in vivo, providing a new strategy for the development of efficient peptide vaccination...
  99. ncbi Rhabdomyolysis and acute renal failure in a child with para-influenza type 1 infection
    Renata Vrsalovic
    Department of Paediatrics, University Hospital Sestre Milosrdnice, Vinogradska 29, Zagreb, Croatia
    Pediatr Nephrol 22:1369-71. 2007
    ..ARF due to rhabdomyolysis in para-influenza type 1 infection in a child has, to the best of our knowledge, not been previously reported...
  100. ncbi SEN viruses and treatment response in chronic hepatitis C virus
    Nikolai V Naoumov
    Lancet 359:1779-80; author reply 1780. 2002
  101. ncbi Isolation and molecular characterization of a novel cytopathogenic paramyxovirus from tree shrews
    C A Tidona
    Institut fur Medizinische Virologie, Universitat Heidelberg, Im Neuenheimer Feld 324, Heidelberg, D 69120, Federal Republic of Germany
    Virology 258:425-34. 1999
    ..Highest homologies were detected between TPMV and Hendra virus (equine morbillivirus), which recently emerged in Australia, causing outbreaks of fatal respiratory and neurological disease in horses and humans...

Research Grants17

  1. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
    ....
  2. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2001
    ....
  3. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2007
    ..abstract_text> ..
  4. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
    ..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
  5. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
    ....
  6. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2002
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  7. Role of ephrins in lung edema due to virus and hypoxia
    Todd Carpenter; Fiscal Year: 2008
    ..These studies will explore novel mechanisms contributing to pulmonary edema formation and may ultimately identify potential sites of therapeutic intervention in that process. [unreadable] [unreadable]..
  8. EFFECT OF VIRUS AND HYPOXIA ON LUNG ENDOTHELIN AND EDEMA
    Todd Carpenter; Fiscal Year: 2004
    ..abstract_text> ..
  9. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..Specific Aim 4: To determine if this multiplex assay is equivalent to these "singleplex" assays in a clinical trial. ..
  10. INTERACTION OF PARAINFLUENZA 3 WITH THE HOST CELL
    Maria Arantxa Horga; Fiscal Year: 2004
    ..The training objective of this application is to acquire both the formal didactic training and the in-depth laboratory experience that will allow me to develop into a first-rate pediatrician-investigator. ..
  11. SUBCLINICAL CMV INFECTION AFTER MARROW TRANSPLANTATION
    William Nichols; Fiscal Year: 2004
    ..This award will support my first step towards obtaining my long-term career goal, which is to be a proficient clinical investigator for infections in the immunocompromised host. ..
  12. Immunomodulatory Mechanisms of Sublingual Immunotherapy
    Louis Rosenthal; Fiscal Year: 2006
    ..To investigate this controversial therapy, these studies will use a novel rat model to compare the efficacy of high vs. low doses of allergen drops and to elucidate mechanisms of sublingual immunotherapy. ..
  13. Recruitment of memory CD8+ T cells to the lung airways
    JACOB KOHLMEIER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Design of peptide entry inhibitors and delivery systems to target emerging henipa
    Anne Moscona; Fiscal Year: 2010
    ..abstract_text> ..
  15. VEGF regulation of surfactant proteins in preventing RSV
    DAVID MEYERHOLZ; Fiscal Year: 2005
    ....
  16. Recombinant Sendai Virus as a Novel HIV Vaccine Vector
    KAREN SLOBOD; Fiscal Year: 2004
    ..Studies described in this application may ultimately identify rSV as an effective intranasal vaccine vehicle useful in the prevention of HIV. ..
  17. Design of peptide entry inhibitors and delivery systems to target emerging henipa
    Anne Moscona; Fiscal Year: 2008
    ..abstract_text> ..