lassa fever

Summary

Summary: An acute febrile human disease caused by the LASSA VIRUS.

Top Publications

  1. ncbi Lassa fever in West African sub-region: an overview
    O Ogbu
    Department of Applied Microbiology, Faculty of Applied and Natural Sciences, Ebonyi State University, Abakaliki, Nigeria
    J Vector Borne Dis 44:1-11. 2007
  2. pmc T cell-dependence of Lassa fever pathogenesis
    Lukas Flatz
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    PLoS Pathog 6:e1000836. 2010
  3. pmc Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever
    Kristian G Andersen
    Department of Organismic and Evolutionary Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 367:868-77. 2012
  4. ncbi Poor housing quality increases risk of rodent infestation and Lassa fever in refugee camps of Sierra Leone
    Phillip Cullison Bonner
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 77:169-75. 2007
  5. pmc Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation
    Danny A Asogun
    Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Edo State, Nigeria
    PLoS Negl Trop Dis 6:e1839. 2012
  6. pmc Risk maps of Lassa fever in West Africa
    Elisabeth Fichet-Calvet
    Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium
    PLoS Negl Trop Dis 3:e388. 2009
  7. pmc Functional interferon system is required for clearance of lassa virus
    Nadezhda E Yun
    Galveston National Laboratory, Institute for Human Infectious and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 86:3389-92. 2012
  8. ncbi Lassa fever vaccine
    Susan P Fisher-Hoch
    University of Texas Houston Health Science Center, School of Public Health, Brownsville Regional Campus, 80 Fort Brown, Brownsville, Texas 78520, USA
    Expert Rev Vaccines 3:189-97. 2004
  9. pmc Lassa fever: epidemiology, clinical features, and social consequences
    J Kay Richmond
    BMJ 327:1271-5. 2003
  10. ncbi New opportunities for field research on the pathogenesis and treatment of Lassa fever
    Sheik Humarr Khan
    Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone
    Antiviral Res 78:103-15. 2008

Detail Information

Publications177 found, 100 shown here

  1. ncbi Lassa fever in West African sub-region: an overview
    O Ogbu
    Department of Applied Microbiology, Faculty of Applied and Natural Sciences, Ebonyi State University, Abakaliki, Nigeria
    J Vector Borne Dis 44:1-11. 2007
    b>Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea, vomiting and, chest and abdominal pain...
  2. pmc T cell-dependence of Lassa fever pathogenesis
    Lukas Flatz
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    PLoS Pathog 6:e1000836. 2010
    Lassa virus (LASV), the causative agent of Lassa fever (LF), is endemic in West Africa, accounting for substantial morbidity and mortality...
  3. pmc Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever
    Kristian G Andersen
    Department of Organismic and Evolutionary Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 367:868-77. 2012
    ..Overall, our study supports the hypothesis that selective pressures imposed by LASV may have led to the emergence of particular alleles conferring resistance to Lassa fever, and opens up new avenues of research pursuit.
  4. ncbi Poor housing quality increases risk of rodent infestation and Lassa fever in refugee camps of Sierra Leone
    Phillip Cullison Bonner
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 77:169-75. 2007
    b>Lassa fever, a viral hemorrhagic fever endemic in parts of West Africa, is a severe febrile illness transmitted to humans by the rodent Mastomys natalensis...
  5. pmc Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation
    Danny A Asogun
    Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Edo State, Nigeria
    PLoS Negl Trop Dis 6:e1839. 2012
    b>Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics...
  6. pmc Risk maps of Lassa fever in West Africa
    Elisabeth Fichet-Calvet
    Evolutionary Ecology Group, University of Antwerp, Antwerp, Belgium
    PLoS Negl Trop Dis 3:e388. 2009
    b>Lassa fever is caused by a viral haemorrhagic arenavirus that affects two to three million people in West Africa, causing a mortality of between 5,000 and 10,000 each year...
  7. pmc Functional interferon system is required for clearance of lassa virus
    Nadezhda E Yun
    Galveston National Laboratory, Institute for Human Infectious and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 86:3389-92. 2012
    ..Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance...
  8. ncbi Lassa fever vaccine
    Susan P Fisher-Hoch
    University of Texas Houston Health Science Center, School of Public Health, Brownsville Regional Campus, 80 Fort Brown, Brownsville, Texas 78520, USA
    Expert Rev Vaccines 3:189-97. 2004
    b>Lassa fever remains a serious challenge to public health in West Africa threatening both local residents in rural areas and those who serve them, particularly medical care providers...
  9. pmc Lassa fever: epidemiology, clinical features, and social consequences
    J Kay Richmond
    BMJ 327:1271-5. 2003
  10. ncbi New opportunities for field research on the pathogenesis and treatment of Lassa fever
    Sheik Humarr Khan
    Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone
    Antiviral Res 78:103-15. 2008
    Unlike many viral hemorrhagic fevers (VHFs), Lassa fever (LF) is not a rare disease that emerges only as sporadic cases or in outbreak form...
  11. pmc Pathogenesis of Lassa fever in cynomolgus macaques
    Lisa E Hensley
    Virology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Virol J 8:205. 2011
    ..fatal hemorrhagic disease in humans and nonhuman primates; however, little is known about the development of Lassa fever. Here, we performed a pilot study to begin to understand the progression of LASV infection in nonhuman primates.
  12. pmc Early blood profiles of virus infection in a monkey model for Lassa fever
    Mahmoud M Djavani
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard St, Baltimore, MD 21201, USA
    J Virol 81:7960-73. 2007
    ..Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease...
  13. pmc Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
    Vaccine 26:5246-54. 2008
    A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination...
  14. pmc Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
    Marcel Asper
    Department of Virology, Bernhard Nocht Institute of Tropical Medicine, 20359 Hamburg, Germany
    J Virol 78:3162-9. 2004
    ..Three low-passage Lassa virus strains (AV, NL, and CSF), isolated from humans with mild to fulminant Lassa fever, were tested...
  15. ncbi Lassa fever in West Africa: evidence for an expanded region of endemicity
    N Sogoba
    Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    Zoonoses Public Health 59:43-7. 2012
    ..virus (LASV) is endemic in Sierra Leone, Guinea and Liberia (known as the Mano River region) and Nigeria and Lassa fever cases from these countries are being reported annually...
  16. pmc Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses
    P Pushko
    Virology Division, United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    J Virol 75:11677-85. 2001
    ....
  17. pmc Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: case report
    Jessica N Grove
    Tulane University Department of Microbiology and Immunology, New Orleans, LA, USA
    Virol J 8:314. 2011
    b>Lassa fever is a neglected tropical disease with a significant impact on the health care system of endemic West African nations...
  18. pmc Characterization of human CD4(+) T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein
    J ter Meulen
    Departments of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Virol 74:2186-92. 2000
    ..must play the major role in controlling acute human Lassa virus infection, because patients recover from acute Lassa fever in the absence of a measurable neutralizing antibody response...
  19. pmc Imported Lassa fever, Pennsylvania, USA, 2010
    Valerianna Amorosa
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Emerg Infect Dis 16:1598-600. 2010
    We report a case of Lassa fever in a US traveler who visited rural Liberia, became ill while in country, sought medical care upon return to the United States, and subsequently had his illness laboratory confirmed...
  20. ncbi NK cells are strongly activated by Lassa and Mopeia virus-infected human macrophages in vitro but do not mediate virus suppression
    Marion Russier
    Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Lyon, France
    Eur J Immunol 42:1822-32. 2012
    ..Overall, these findings show that MOPV- as well as pathogenic LASV-infected macrophages mediate NK-cell activation...
  21. pmc Advanced vaccine candidates for Lassa fever
    Igor S Lukashevich
    Department of Pharmacology and Toxicology, School of Medicine, and Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Kentucky, USA
    Viruses 4:2514-57. 2012
    ..The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF)...
  22. pmc Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease
    Kathryn M Hastie
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e44211. 2012
    ....
  23. ncbi Lassa fever in Guinea: II. Distribution and prevalence of Lassa virus infection in small mammals
    A H Demby
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases (NCID, Centers for Disease Control and Prevention (CDC, Atlanta, GA 30333, USA
    Vector Borne Zoonotic Dis 1:283-97. 2001
    ..form the reservoir for Lassa virus (LV), an arenavirus that causes a potentially severe hemorrhagic illness, Lassa fever (LF). Although Mastomys rodents exist throughout sub-Saharan Africa, areas of human LF appear to be quite focal...
  24. pmc A live attenuated vaccine for Lassa fever made by reassortment of Lassa and Mopeia viruses
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    J Virol 79:13934-42. 2005
    ..Detailed examination of two rhesus macaques infected with this MOPV/LAS reassortant revealed no histological lesions or disease signs. Thus, ML29 is a promising attenuated vaccine candidate for Lassa fever.
  25. ncbi Early-onset sensorineural hearing loss in Lassa fever
    T S Ibekwe
    Lassa Fever Research and Diagnostic Centre, Irrua Specialist Teaching Hospital, Irrua, Nigeria
    Eur Arch Otorhinolaryngol 268:197-201. 2011
    b>Lassa fever (LF) is a viral hemorrhagic disease which affects one-fourth to two million people annually with the fatality rate of about 10,000. It is associated with sensorineural hearing loss (SNHL) usually at the convalescent stage...
  26. ncbi Management of viral haemorrhagic fever in the Netherlands
    C M Swaan
    GGD Zuid Holland Noord, Leiden, Netherlands
    Euro Surveill 7:48-50. 2002
    Two cases of Lassa fever have been reported in the Netherlands since viral haemorrhagic fevers became notifiable diseases in 1978...
  27. ncbi Prevention of lassa Fever in Nigeria
    Ute Inegbenebor
    Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
    Trans R Soc Trop Med Hyg 104:51-4. 2010
    Although specific treatment is available for Lassa fever, early diagnosis is still difficult in most Nigerian primary and secondary health centers...
  28. ncbi Experimental study on the possibility of treatment of some hemorrhagic fevers
    G Ignatyev
    State Research Center of Virology and Biotechnology Vector, Novosibirsk Region, 633159, Koltsovo, Russia
    J Biotechnol 83:67-76. 2000
    ..5 ml (2000 U ml(-1); 1 U of the antiserum neutralises 0.03 ng of TNF-alpha), everyday, within 6 days from the third day after the challenge...
  29. pmc Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-alpha gene expression
    I S Lukashevich
    Department of Pathology, University of Wisconsin, Madison, Wisconsin, USA
    J Med Virol 59:552-60. 1999
    ..The cumulative down-regulation of TNF-alpha and IL-8 expression could explain the absence of inflammatory and effective immune responses in severe cases of Lassa HF...
  30. ncbi Imported Lassa fever in Germany: surveillance and management of contact persons
    Walter H Haas
    Robert Koch Institute, Berlin, Germany
    Clin Infect Dis 36:1254-8. 2003
    This study sought to assess the risk of secondary transmission after import of Lassa fever into Europe. A total of 232 persons exposed to a case of Lassa fever imported into Germany were identified...
  31. pmc Lassa fever, Nigeria, 2003 and 2004
    Sunday Aremu Omilabu
    Emerg Infect Dis 11:1642-4. 2005
  32. ncbi Towards a human Lassa fever vaccine
    S P Fisher-Hoch
    University of Texas School of Public Health at Brownsville, 80 Fort Brown, SET B 1 334, Brownsville, Texas 78520, USA
    Rev Med Virol 11:331-41. 2001
    Arenaviruses, such as Lassa fever, establish chronic infections in rodents, leading to incidental transmission to humans. Lassa fever is a clinically severe disease, yet the absence of second attacks implies life-long immunity...
  33. pmc Historical Lassa fever reports and 30-year clinical update
    Abe M Macher
    US Public Health Service, Bethesda, Maryland, USA
    Emerg Infect Dis 12:835-7. 2006
    Five cases of Lassa fever have been imported from West Africa to the United States since 1969. We report symptoms of the patient with the second imported case and the symptoms and long-term follow-up on the patient with the third case...
  34. ncbi Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses
    Siddhartha Mahanty
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 170:2797-801. 2003
    ..These data represent the first evidence for a mechanism by which Ebola and Lassa viruses target DC to impair adaptive immunity...
  35. pmc Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues
    Ricardo Carrion
    Department of Virology and Immunology, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    J Virol 81:6482-90. 2007
    ..In an attempt to develop a small nonhuman primate model of Lassa fever, common marmosets were subcutaneously inoculated with Lassa virus strain Josiah...
  36. pmc Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Antiviral Res 92:125-38. 2011
    Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human ..
  37. ncbi Construction of a recombinant vaccinia virus expressing the Lassa virus glycoprotein gene and protection of guinea pigs from a lethal Lassa virus infection
    D D Auperin
    Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 30333
    Virus Res 9:233-48. 1988
    ..The vaccinated guinea pigs did, however, develop transient, low-grade, fevers and detectable viremias following infection with Lassa virus, indicating that protection was not complete...
  38. pmc Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice
    Agnieszka Boesen
    Department of Microbiology and Immunology, City University of New York Medical School, New York, New York 10031, USA
    Clin Diagn Lab Immunol 12:1223-30. 2005
    b>Lassa fever is a hemorrhagic disease caused by Lassa fever virus (LV)...
  39. pmc Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone
    J Daniel Kelly
    Department of Tropical Medicine, Tulane School of Public Health and Tropical Medicine, 1430 Tulane Avenue SL 17, New Orleans, LA, 70112, USA
    BMC Int Health Hum Rights 13:2. 2013
    ..One such disease is Lassa fever, an acute and sometimes severe viral hemorrhagic illness endemic in West Africa...
  40. pmc A recently isolated Lassa virus from Mali demonstrates atypical clinical disease manifestations and decreased virulence in cynomolgus macaques
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, NationalInstitute of Allergy and Infectious Diseases National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    J Infect Dis 207:1316-27. 2013
    ..of Soromba-R, a Lassa virus strain recently isolated from southern Mali, was assessed in 2 animal models of Lassa fever: inbred strain 13 guinea pigs and cynomolgus macaques...
  41. pmc Pathogenesis of Lassa fever
    Nadezhda E Yun
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    Viruses 4:2031-48. 2012
    Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality ..
  42. pmc A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity
    Ricardo Carrion
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Vaccine 25:4093-102. 2007
    ..These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection...
  43. pmc The first cases of Lassa fever in Ghana
    E K Dzotsi
    Disease Surveillance Department, Ghana Health Service, Accra, Ghana
    Ghana Med J 46:166-70. 2012
    b>Lassa fever is a zoonotic disease endemic in West Africa but with no previous case reported in Ghana...
  44. pmc Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs
    Xiaohong Jiang
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Vaccine 29:1248-57. 2011
    Yellow Fever (YF) and Lassa Fever (LF) are two prevalent hemorrhagic fevers co-circulating in West Africa and responsible for thousands of deaths annually...
  45. pmc A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins
    Peter J Bredenbeek
    Department of Medical Microbiology, Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Virology 345:299-304. 2006
    ..A single subcutaneous injection of the recombinant vaccine protected strain 13 guinea pigs against fatal Lassa Fever. This study demonstrates the potential to develop an YFV17D-based bivalent vaccine against two viruses that are ..
  46. pmc A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection
    Nell Bond
    Tulane School of Public Health and Tropical Medicine, Department of Tropical Medicine, New Orleans, LA, USA
    Am J Trop Med Hyg 88:241-4. 2013
    b>Lassa fever is an acute and sometimes severe viral hemorrhagic illness endemic in West Africa. One important question regarding Lassa fever is the duration of immunoglobulin G (IgG) antibody after infection...
  47. pmc Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus
    M Djavani
    Institute of Human Virology, University of Maryland Biotechnology Center, Baltimore 21201, USA
    J Hum Virol 4:103-8. 2001
    OBJECTIVES: Lassa fever virus (LAS) is transmitted to man by rodent carriers and is fatal in a third of untreated cases. Our goal is to provide immune protection from Lassa fever by mucosal vaccination...
  48. ncbi Low levels of interleukin-8 and interferon-inducible protein-10 in serum are associated with fatal infections in acute Lassa fever
    S Mahanty
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 183:1713-21. 2001
    To investigate the role of inflammatory mediators in the pathogenesis of Lassa fever, the levels of a number of pro- and anti-inflammatory cytokines and chemokines in serum samples collected from hospitalized patients with fatal and ..
  49. pmc Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 86:2067-78. 2012
    Although O-mannosylated dystroglycan is a receptor for Lassa virus, a causative agent of Lassa fever, recent findings suggest the existence of an alternative receptor(s)...
  50. pmc Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection
    Luis M Branco
    Autoimmune Technologies, LLC, New Orleans, Louisiana, USA
    Virol J 8:478. 2011
    b>Lassa fever (LF) is a devastating hemorrhagic viral disease that is endemic to West Africa and responsible for thousands of human deaths each year...
  51. ncbi Reverse ELISA for IgG and IgM antibodies to detect Lassa virus infections in Africa
    Petra Emmerich
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20356 Hamburg, Germany
    J Clin Virol 37:277-81. 2006
    ..Anti-Lassa antibodies are detected by indirect immunofluorescence assay (IFA) or by enzyme-immunoassay (ELISA). Both methods have problems to detect low amounts of specific antibodies...
  52. ncbi Lassa fever: implications of T-cell immunity for vaccine development
    J ter Meulen
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Biotechnol 73:207-12. 1999
    b>Lassa fever is a re-emerging viral hemorrhagic fever, which causes significant human morbidity in endemic regions of West Africa...
  53. pmc Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan
    Stefan Kunz
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 79:5979-87. 2005
    The cellular receptor for the Old World arenaviruses Lassa fever virus (LFV) and lymphocytic choriomeningitis virus (LCMV) has recently been identified as alpha-dystroglycan (alpha-DG), a cell surface receptor that provides a molecular ..
  54. ncbi The role of the vascular endothelium in arenavirus haemorrhagic fevers
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 102:1024-9. 2009
    ..The most important pathogen among the arenaviruses is Lassa virus (LASV), the causative agent of Lassa fever that is endemic to West Africa...
  55. ncbi Management of a patient with Lassa fever to prevent transmission
    C M Swaan
    J Hosp Infect 55:234-5. 2003
  56. pmc Development of a new vaccine for the prevention of Lassa fever
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    PLoS Med 2:e183. 2005
    Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health challenge of emerging viruses...
  57. pmc The impact of human conflict on the genetics of Mastomys natalensis and Lassa virus in West Africa
    Aude Lalis
    Departement Systematique et Evolution, Museum national d histoire naturelle, Paris, France
    PLoS ONE 7:e37068. 2012
    ..in the rodent populations, the consequent virus population decline, and the coincident increased incidence of Lassa fever in these regions...
  58. pmc Development of recombinant nucleoprotein-based diagnostic systems for Lassa fever
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Clin Vaccine Immunol 14:1182-9. 2007
    Diagnostic systems for Lassa fever (LF), a viral hemorrhagic fever caused by Lassa virus (LASV), such as enzyme immunoassays for the detection of LASV antibodies and LASV antigens, were developed using the recombinant nucleoprotein (rNP) ..
  59. ncbi [Use of guinea pigs for assessing the efficacy of vaccines against Lassa fever]
    I V Firsova
    Vopr Virusol 48:43-5. 2003
    ..guinea pigs as a laboratory model was proven to be appropriate in investigating the vaccines developed against Lassa fever at the preclinical study stage...
  60. pmc Genetic diversity among Lassa virus strains
    M D Bowen
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 74:6992-7004. 2000
    The arenavirus Lassa virus causes Lassa fever, a viral hemorrhagic fever that is endemic in the countries of Nigeria, Sierra Leone, Liberia, and Guinea and perhaps elsewhere in West Africa...
  61. ncbi Antibodies to Lassa virus Z protein and nucleoprotein co-occur in human sera from Lassa fever endemic regions
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Med Microbiol Immunol 189:225-9. 2001
    ..existence of an antibody response and to test the suitability of these antibodies for serosurveys, sera from Lassa fever endemic regions (Guinea and Nigeria, n = 75) were tested for co-reactivity to Z protein and nucleoprotein (NP)...
  62. ncbi Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations
    D G Bausch
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases NCID, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Vector Borne Zoonotic Dis 1:269-81. 2001
    The arenavirus Lassa is found in West Africa, where it sometimes causes a severe illness called Lassa fever. Lassa fever has been seldom investigated outside of a few hyperendemic regions, where the described epidemiology may differ from ..
  63. pmc Improved detection of Lassa virus by reverse transcription-PCR targeting the 5' region of S RNA
    Stephan Olschlager
    Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Bernhard Nocht Strasse 74, Hamburg 20359, Germany
    J Clin Microbiol 48:2009-13. 2010
    ..of the new assay, the GPC RT-PCR/2007 assay, took into account 62 S RNA sequences from all countries where Lassa fever is endemic, including 40 sequences generated from the strains in our collection...
  64. pmc Mastomys natalensis and Lassa fever, West Africa
    Emilie Lecompte
    Philipps University Institute of Virology, Marburg, Germany
    Emerg Infect Dis 12:1971-4. 2006
    ..Distribution of this rodent and relative abundance compared with M. erythroleucus correlates geographically with Lassa virus seroprevalence in humans...
  65. ncbi A clinical guide to viral haemorrhagic fevers: Ebola, Marburg and Lassa
    Benjamin Jeffs
    Medicens Sans Frontieres, Spain
    Trop Doct 36:1-4. 2006
    ..This article gives a brief overview of diseases caused by the Ebola, Marburg and Lassa viruses. It gives some practical advice to the clinician on the diagnosis and management of these diseases...
  66. ncbi Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever
    Elena Sbrana
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, 77555 0609, USA
    Am J Trop Med Hyg 74:1096-102. 2006
    ..findings in the Pirital virus-infected hamsters were very similar to those reported in severe human cases of Lassa fever, suggesting that this new animal model could serve as a low-cost and relatively safe alternative for studying ..
  67. pmc Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model
    Marco A Goicochea
    Institute of Human Virology, University of Maryland, School of Medicine, Baltimore, MD 21201, United States
    Vaccine 30:1445-52. 2012
    b>Lassa fever (LF) is one of the most prevalent viral hemorrhagic fevers in West Africa responsible for thousands of deaths annually...
  68. pmc Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report
    Luis M Branco
    Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, USA
    Virol J 8:404. 2011
    b>Lassa fever (LF) is a devastating viral disease prevalent in West Africa...
  69. pmc Current molecular epidemiology of Lassa virus in Nigeria
    Deborah U Ehichioya
    Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria
    J Clin Microbiol 49:1157-61. 2011
    ..The Bayesian analysis also provided estimates for divergence times within the Lassa virus clade...
  70. pmc Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever
    Luis M Branco
    Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 7:279. 2010
    b>Lassa fever is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic...
  71. ncbi Review of the literature and proposed guidelines for the use of oral ribavirin as postexposure prophylaxis for Lassa fever
    Daniel G Bausch
    Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Clin Infect Dis 51:1435-41. 2010
    b>Lassa fever is an acute viral hemorrhagic illness; the virus is endemic in West Africa and also of concern with regard to bioterrorism...
  72. ncbi Strain-specific antibody response to Lassa virus in the local population of west Africa
    Petra Emmerich
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Street 74, D 20359 Hamburg, Germany
    J Clin Virol 42:40-4. 2008
    ..b>Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum. J Infect Dis 2001;184:345-9]...
  73. ncbi Lessons from nosocomial viral haemorrhagic fever outbreaks
    Susan P Fisher-Hoch
    Department of Epidemiology, University of Texas Houston Health Science Center, School of Public Health, Brownsville Campus, Brownsville, TX, USA
    Br Med Bull 73:123-37. 2005
    ..Educating the public to demand higher standards could be a powerful tool. Good practices are difficult to establish and maintain on the scale needed...
  74. ncbi Monitoring of clinical and laboratory data in two cases of imported Lassa fever
    Herbert Schmitz
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 4:43-50. 2002
    During 2000, four cases of fatal Lassa fever were imported from Africa to Europe. In two patients, consecutive serum samples were available for monitoring of virus load and cytokine levels in addition to standard laboratory data...
  75. ncbi [A man with fatal Lassa fever following a stay in Sierra Leone]
    P J Veldkamp
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:2201-4. 2002
    ..This was the first case of Lassa fever diagnosed in the Netherlands since 1980...
  76. ncbi Imported viral haemorrhagic fever with a potential for person-to-person transmission: review and recommendations for initial management of a suspected case in Belgium
    R Colebunders
    Departement Klinische Wetenschappen, Instituut voor Tropische Geneeskunde Nationalestraat 155, B 2000 Antwerpen
    Acta Clin Belg 57:233-40. 2002
    ..from person to person and able to cause nosocomial outbreaks with a high case fatality rate: an arenavirus (Lassa fever and more exceptionally the Junin and Machupo virus), a bunyavirus (Crimean-Congo haemorrhagic fever) and the ..
  77. ncbi Lassa fever
    J B McCormick
    University of Texas, School of Public Health, Brownsville, TX, USA
    Curr Top Microbiol Immunol 262:75-109. 2002
  78. ncbi Clinical features of Lassa fever in Liberia
    J D Frame
    Division of Tropical Medicine, School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Rev Infect Dis 11:S783-9. 1989
    Two hundred thirteen cases of Lassa fever (LF) were diagnosed by virus isolation and seroconversion at Curran Lutheran Hospital in Zorzor, Liberia, between July 1980 and April 1986...
  79. pmc Imported lassa fever in Germany: molecular characterization of a new lassa virus strain
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Emerg Infect Dis 6:466-76. 2000
    ..This strain, designated "AV," originated from a region in West Africa where Lassa fever has not been reported. Viral S RNA isolated from the patient's serum was amplified and sequenced...
  80. pmc Detection of Lassa virus antinucleoprotein immunoglobulin G (IgG) and IgM antibodies by a simple recombinant immunoblot assay for field use
    J ter Meulen
    Medical Microbiology Section, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    J Clin Microbiol 36:3143-8. 1998
    ..7%) and was lower for the Liberian samples (75%). Acute Lassa fever was diagnosed by PCR in 12 of 59 (20...
  81. pmc Diagnosis and clinical virology of Lassa fever as evaluated by enzyme-linked immunosorbent assay, indirect fluorescent-antibody test, and virus isolation
    D G Bausch
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:2670-7. 2000
    ..virus (an arenavirus) is found in West Africa, where it sometimes causes a severe hemorrhagic illness called Lassa fever. Laboratory diagnosis has traditionally been by the indirect fluorescent-antibody (IFA) test...
  82. ncbi The public health response to a case of Lassa fever in London in 2000
    N S Crowcroft
    Immunisation Division, Public Health Laboratory Service PHLS Communicable Disease Surveillance Centre CDSC, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Infect 48:221-8. 2004
    ..Evaluation of the Department of Health 1996 guidance, the Memorandum on the Management and Control of Viral Haemorrhagic Fevers...
  83. pmc Protection of rhesus monkeys from fatal Lassa fever by vaccination with a recombinant vaccinia virus containing the Lassa virus glycoprotein gene
    S P Fisher-Hoch
    Centers for Disease Control, Atlanta, GA 30333
    Proc Natl Acad Sci U S A 86:317-21. 1989
    b>Lassa fever is an acute febrile disease of West Africa, where there are as many as 300,000 infections a year and an estimated 3000 deaths...
  84. ncbi Protection of guinea pigs from Lassa fever by vaccinia virus recombinants expressing the nucleoprotein or the envelope glycoproteins of Lassa virus
    H G Morrison
    Division of Viral Diseases, Center for Infectious Diseases, Atlanta, Georgia 30333
    Virology 171:179-88. 1989
    ..from vaccination with the recombinant virus vaccines did not correlate with the levels of prechallenge serum antibodies, suggesting that a cell-mediated immune response is a critical component of protective immunity to Lassa fever.
  85. ncbi Lassa virus activity in Guinea: distribution of human antiviral antibody defined using enzyme-linked immunosorbent assay with recombinant antigen
    I S Lukashevich
    , Kindia, Guinea
    J Med Virol 40:210-7. 1993
    ..The highest prevalence of LVA in hospital staff (29-40%) was in the Gueckedou and Lola hospitals. Sera of LVA-positive persons were tested via Western blot analysis. Antibodies bound predominantly to NP and GP2 proteins...
  86. pmc Identification of protective Lassa virus epitopes that are restricted by HLA-A2
    Jason Botten
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 80:8351-61. 2006
    ....
  87. ncbi Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa
    Elisabeth Fichet-Calvet
    Department of Systematics and Evolution, Museum national d histoire naturelle, Paris, France
    Vector Borne Zoonotic Dis 7:119-28. 2007
    Based on empiric surveillance data, the incidence of human Lassa fever (LF) cases in Guinea and other West African countries has been reported to increase during the dry season compared to the rainy season...
  88. ncbi Lassa virus
    Stephan Gunther
    Department of Virology, Bernhard Nocht Institute of Tropical Medicine, Hamburg, Germany
    Crit Rev Clin Lab Sci 41:339-90. 2004
    ..It was discovered as the causative agent of a hemorrhagic fever--Lassa fever--about 30 years ago...
  89. ncbi Reproductive characteristics of Mastomys natalensis and Lassa virus prevalence in Guinea, West Africa
    Elisabeth Fichet-Calvet
    Department of Systematics and Evolution, Museum national d histoire naturelle, Paris, France
    Vector Borne Zoonotic Dis 8:41-8. 2008
    ..Rodent behavior influencing virus transmissibility and contaminated environment may therefore be responsible for spatial and seasonal variations in LASV prevalence in M. natalensis...
  90. ncbi Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, D 20359 Hamburg, Germany
    J Infect Dis 184:345-9. 2001
    The pathogenesis of neurologic complications of Lassa fever is poorly understood...
  91. ncbi [How to treat a patient with indications for an infectious viral hemorrhagic fever]
    L G Visser
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:2183-8. 2002
    ..Using this approach it is possible to diagnose high-risk patients in good time and to take appropriate measures...
  92. doi Human pathogenic arenaviruses
    Marylou V Solbrig
    Ann Neurol 64:355-6; author reply 356. 2008
  93. pmc Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus
    Stefanie Müller
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Antimicrob Agents Chemother 51:2215-8. 2007
    ....
  94. ncbi Amino acids from both N-terminal hydrophobic regions of the Lassa virus envelope glycoprotein GP-2 are critical for pH-dependent membrane fusion and infectivity
    Christian Klewitz
    The Institute for Virology, Philipps University, Hans Meerwein Strasse 3, 35043 Marburg, Germany
    J Gen Virol 88:2320-8. 2007
    ..The data demonstrate that several amino acids from both hydrophobic regions of the N terminus, some of which (W264, G277, Y278 and L280) are 100 % conserved in all arenaviruses, are involved in fusogenicity and infectivity of LASV GP-2...
  95. ncbi RT-PCR assay for detection of Lassa virus and related Old World arenaviruses targeting the L gene
    Simon Vieth
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Trans R Soc Trop Med Hyg 101:1253-64. 2007
    ..demonstrated with in vitro transcribed RNA, material from infected cell cultures and samples from patients with Lassa fever and monkeys with LCMV-associated callitrichid hepatitis...
  96. ncbi Lassa virus-infected rodents in refugee camps in Guinea: a looming threat to public health in a politically unstable region
    Joseph Fair
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Vector Borne Zoonotic Dis 7:167-71. 2007
    ..We assessed the risk of Lassa fever to refugees and humanitarian aid workers in the Forest Region of Guinea by trapping rodents and testing them ..
  97. ncbi [Lassa fever]
    Masayuki Saijo
    Department of Virology 1, National Institute of Infectious Diseases
    Nihon Rinsho 65:40-3. 2007
  98. ncbi [Viral hemorrhagic fevers--Ebola hemorrhagic fever, Marburg virus disease, and Lassa fever]
    Kiyosu Taniguchi
    Nihon Naika Gakkai Zasshi 93:2303-8. 2004
  99. ncbi Lassa virus: seroepidemiological survey of rodents caught in Ekpoma and environs
    L E Okoror
    Department of Microbiology, Faculty of Natural Sciences, Ambrose Alli University, Ekpoma, Edo State Nigeria
    Trop Doct 35:16-7. 2005
    ..Of the 218 M. natalensis caught, 102 (46.79%) were positive for complement fixing antibody to Lassa virus...
  100. ncbi [Lissavirus in bats residing in the South of West Siberia]
    V A Ternovoi
    Vopr Virusol 50:31-5. 2005
    ..According to the results, bats can be involved in keeping alive the rabies foci in Western Siberia, which must be taken into account in antiepizootic measures...
  101. ncbi [Lassa virus]
    Shigeru Morikawa
    Department of Virology I, National Institute of Infectious Diseases
    Nihon Rinsho 61:539-43. 2003

Research Grants64

  1. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..g. Ebola virus, Lassa fever virus, Dengue virus, etc.)...
  2. Novel Screen to Identify Arenavirus Inhibitors
    Juan Lama; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lassa fever virus (LASV) and other members of the arenavirus family are important human pathogens that can cause hemorrhagic fevers with mortality rates over 20%...
  3. Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.
    Juan C de la Torre; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Several arenaviruses, chiefly Lassa fever virus, cause severe hemorrhagic fever (HF) disease in humans, and evidence indicates that the worldwide-..
  4. Antibody immunotherapeutics for biodefense against Lassa virus
    Robert F Garry; Fiscal Year: 2013
    ..Immunotherapeutics for Biodefense against Lassa virus (LASV), an arenavirus that is the causative agent of Lassa fever (LF). LASV is a Biosafety Level 4 and NIAID Biodefense category A agent...
  5. Tulane-Xavier Minority Training in International Health
    Richard A Oberhelman; Fiscal Year: 2013
    ..and mortality in Argentina, Chagas disease in Mexico, clinical trials of new antimalarial drugs in Mali, Lassa Fever and tropical diseases in Sierra Leone, cardiovascular diseases in China, and health behaviors of migrants in ..
  6. Opening a New Lassa Fever Ward in Kenema Sierra Leone
    Robert F Garry; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lassa fever (LF) is an acute and often fatal hemorrhagic disease that is endemic in the West African countries of Sierra Leone, Guinea, Liberia and Nigeria...
  7. Evaluation of LASV Protective Immunity in Mice Using Reassortant Virus ML29
    MARCO AURELIO GOICOCHEA; Fiscal Year: 2010
    Lassa virus (LASV) is the causative agent of Lassa Fever (LF), a zoonotic viral hemorrhagic fever endemic in West Africa responsible for wide spread disease and significant morbidity and mortality...
  8. A Lassa Vaccine in primates with AIDS
    Maria Salvato; Fiscal Year: 2009
    A Lassa vaccine in primates with AIDS Lassa fever virus is a rodent-borne scourge in West Africa and, less has been classified as a Category A biothreat in the US because of its lethality and aerosol-transmissibility...
  9. Molecular determinants of virulent arenavirus infection in hosts
    Yuying Liang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arenaviruses such as Lassa fever virus (LASV) can cause acute viral hemorrhagic fever disease in humans, to which there is no vaccine or effective treatment...
  10. Host Genetic Factors to Combat Lassa Hemorrhagic Fever
    Michael B Oldstone; Fiscal Year: 2013
    ..Lessons learned from lymphocytic choriomeningitis virus (LCMV) are applied to Lassa fever virus (LASV). LASV infects over 300,000 individuals per year resulting in over 20,000 deaths...
  11. Novel Mechanism of Immune Evasion by Arenaviral Nucleoproteins
    Hinh Ly; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arenaviruses such as Lassa fever virus (LASV) are known to cause deadly hemorrhagic fever diseases in human with little preventive or prophylactic measures...
  12. Preclinical development of recombinant antigen diagnostics for Lassa fever
    Robert F Garry; Fiscal Year: 2013
    This project will develop Diagnostics For Biodefense against Lassa fever, a severe, often fatal viral hemorrhagic fever (VHF)...
  13. Host and Pathogen Evolution in Lassa Fever
    Pardis Sabeti; Fiscal Year: 2010
    ..A genome-wide survey of human variation identified two genes biologically linked to Lassa fever as among the strongest signals of natural selection in West Africans1...
  14. Broad Spectrum Treatment of Hemmorrhagic Arenaviruses
    Philip E Thorpe; Fiscal Year: 2010
    ..Bavituximab cured guinea pigs lethally infected with Pichinde virus (a model of Lassa fever). It also protected mice from lethal challenge with mCMV...
  15. Cap snatching mechanism of arenaviruses
    Hinh Ly; Fiscal Year: 2011
    Abstract Arenaviruses such as Lassa fever virus (LASV) can cause acute viral hemorrhagic fever disease in humans to which there is no vaccine or effective treatment...
  16. Host and Microbial Genetic Determinants of Febrile Illness in West Africa
    Christian Happi; Fiscal Year: 2013
    ..US partners at the Broad Institute, Harvard University, and Tulane University studying the devastating diseases Lassa fever (LF) and Plasmodium falciparum malaria...
  17. HTS for Filo- and Arena-virus Entry Mechanisms
    Robert A Davey; Fiscal Year: 2010
    ..qHTS at NCGC to identify compounds that inhibit infection of Marburg (a filovirus related to Ebola virus) and Lassa Fever virus (an arenavirus)...
  18. Roles of protective or pathogenic B cell epitopes in human Lassa Fever
    James Robinson; Fiscal Year: 2011
    ..This contract will identify epitopes from Lassa Fever virus.
  19. Roles of protective or pathogenic B cell epitopes in human Lassa Fever
    James Robinson; Fiscal Year: 2009
    ..This contract will identify epitopes from Lassa Fever virus.
  20. Roles of protective or pathogenic B cell epitopes in human Lassa Fever
    James Robinson; Fiscal Year: 2012
    ..This contract will identify epitopes from Lassa Fever virus.
  21. Antiviral Drugs for Arenaviruses
    Sean M Amberg; Fiscal Year: 2013
    ..applicant): The goal of the program described here is to develop an antiviral drug for treating and preventing Lassa fever and other hemorrhagic fevers of arenavirus origin...
  22. Antiviral Drugs Against Hemorrhagic Fever Viruses
    Dennis Hruby; Fiscal Year: 2003
    ..Hemorrhagic fever viruses (HFVs), in particular Lassa fever (Arenaviridae), Rift Valley fever (Bunyaviridae), and Ebola and Marburg (Filoviridae) viruses are potential ..
  23. ANTIVIRAL DRUG DELIVERY WITH LYOPHILIZED PLATELETS
    Thomas Fischer; Fiscal Year: 2004
    ..Viruses of the Arenaviridea (e.g., Lassa fever virus), Filoviridae (e.g., Ebola and Marburg viruses), Bunyaviridae (e.g...
  24. Mopeia/Lassa Virus Reassortants as Lassa Fever Vaccines
    Igor Lukashevich; Fiscal Year: 2002
    ..Our studies focus on Lassa fever virus due to its virulence for human beings...
  25. Cytokine patterns in guinea pig arenavirus disease
    Judith Aronson; Fiscal Year: 2004
    ..model utilizes a PIC variant (P18) which has been "adapted" by serial guinea pig passages to cause a severe, Lassa fever-like disease in guinea pigs...
  26. Dendritic Cell Targeting of Lassa Fever Vaccine
    Maria Salvato; Fiscal Year: 2005
    ..immunity, we will replace the LCMV-GP gene with DNA encoding antigens associated with protective immunity in Lassa fever (Lassa NP and GP genes)...
  27. Immune epitope database and analyisis program: infectious diseases
    ALESSANDRO D SETTE; Fiscal Year: 2009
    ..been curated into the IEDB, which includes epitopes for NIAID's category A-C prioroity pathogens such as lassa fever virus, hantavirus, ricin toxin, ebola virus, and marburg virus...
  28. Immune Epitope Database: Infectious diseases
    Alessandro Sette; Fiscal Year: 2012
    ..been curated into the IEDB, which includes epitopes for NIAID's category A-C prioroity pathogens such as lassa fever virus, hantavirus, ricin toxin, ebola virus, and marburg virus...
  29. Immune Epitope Database: Infectious diseases
    Alessandro Sette; Fiscal Year: 2013
    ..been curated into the IEDB, which includes epitopes for NIAID's category A-C prioroity pathogens such as lassa fever virus, hantavirus, ricin toxin, ebola virus, and marburg virus...
  30. MUCOSAL INFECTION WITH ARENAVIRUS
    Igor Lukashevich; Fiscal Year: 2000
    Arenaviruses are rodent-borne viruses that cause fatal illness when transmitted to man. Lassa fever virus in Africa and Machupo virus in Bolivia are two arenaviruses that have caused noteable outbreaks in the last few years...
  31. IMMUNOLOGIC & EPIDEMIOLOGIC STUDIES OF EMERGING VIRUSES
    Michael Buchmeier; Fiscal Year: 1999
    ..and epidemiologic approaches to study the pathogenesis and natural history of three emerging viruses: Lassa fever virus, Ebola virus and Sin Nombre virus...
  32. Vaccination for LASSA FEVER
    Michael Buchmeier; Fiscal Year: 2005
    ..to understand the protective immune response to Lassa virus, thus positioning us to develop a vaccine against Lassa fever. Lassa virus is a Biosafety level 4 (BSL4) agent, and the constraints imposed by this fact have significantly ..
  33. Novel Anti-Viral Agents for Treating Lassa Fever
    Philip Thorpe; Fiscal Year: 2007
    ..We propose to develop ch3G4 first for treating Lassa fever. Development studies will be conducted in a guinea pig model, which uses the arenavirus, Pichinde, to mimic ..
  34. Early Response to Hemorrhagic Fever-Causing Arenaviruses
    Maria Salvato; Fiscal Year: 2003
    ..will address the need for diagnostics to identify infection with a virulent hemorrhagic fever virus, Lassa fever virus (LASV). Within hours of entering the body, pathogens elicit responses from circulating white blood cells...
  35. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael Oldstone; Fiscal Year: 2003
    ..isolated and characterized the cellular receptor, alpha-dystroglycan ((-DG) for several arenaviruses including Lassa fever virus (LFV) and LCMV CI 13. We provided evidence that (-DG is the receptor required for infection (Cao et al...
  36. Antiviral Drugs for Lassa Fever Virus
    SEAN AMBERG; Fiscal Year: 2008
    ..b>Lassa fever virus in particular annually infects several hundred thousand individuals in West Africa, and the export of ..
  37. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  38. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  39. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  40. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  41. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  42. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  43. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  44. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..We found a-DG was the only receptor required for all Old World (LCMV, Lassa fever virus [LFV]) and New World Clade C viruses (Latino, Oliveros) (J. Virol. 76, 2002)...
  45. Recombinant antigen assays for Lassa and other arenaviru
    Robert Garry; Fiscal Year: 2005
    ....
  46. Cellular receptors for pathogenic New World arenaviruses
    Stefan Kunz; Fiscal Year: 2007
    ..In a complementary approach, biochemical techniques, combined with mass spectrometry, will therefore be used for the identification of candidate receptors for this important human pathogen. [unreadable] [unreadable] [unreadable]..
  47. Novel Antiviral Strategy to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..is an excellent model to study the molecular and cellular biology of hemorrhagic fever arenaviruses, including Lassa fever virus (LFV). These viruses cause severe human disease, and they pose a real threat as agents of bioterrorism...
  48. Aminoglycoside Antivirals to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..to study the molecular and cellular biology of arenaviruses that cause important and severe human diseases like Lassa fever virus (LFV) and the South American viral hemorrhagic fevers (SAHF)...
  49. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..Conditions required for reconstitution of BDV transcription and RNA replication by intracellular coexpression of BDV minigenome and BDV proteins from separated plasmids will be determined. ..
  50. Identification of Borna Disease Virus Receptor Proteins
    JUAN DE LA TORRE; Fiscal Year: 2006
    ..G*/p56; 3) Determination of expression pattern of BDV candidate receptors in vivo. ..
  51. Anti-interferon Activity of the Arenavirus Nucleoprotein
    JUAN DE LA TORRE; Fiscal Year: 2008
    ..abstract_text> ..
  52. Biology of Animal Nuclear Mononegaviruses
    JUAN DE LA TORRE; Fiscal Year: 2008
    ..abstract_text> ..
  53. Neuroimmunologic Disorders Induced by Chronic Viral Infection
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..We will use biochemical, genetics and functional assays to assess the relevance in Arenavirus biology of candidates initially identified by TAP/MS. ..
  55. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..abstract_text> ..
  56. Structure-function of Junin virus envelope glycoproteins
    JACK NUNBERG; Fiscal Year: 2005
    ..This application is submitted in response to PA-03-080 for Biodefense and Emerging Infectious Disease Research. ..
  57. MOP/LAS chimeric vaccine against Lassa fever
    Igor Lukashevich; Fiscal Year: 2007
    ..Our studies focus on Lassa fever virus due to its virulence for human beings...
  58. Chimeric hepatitis C vaccine vector
    JACK NUNBERG; Fiscal Year: 2004
    ..Viable chimeric viruses will enable the study in cell culture of HCV binding and entry, as well as virion assembly and morphogenesis, and may provide a starting point towards the development of an attenuated HCV vaccine. ..
  59. Lethal Mutagenesis as an Antiviral Strategy
    Craig Cameron; Fiscal Year: 2007
    ..Lethal mutagens should have broad-spectrum activity against RNA viruses, thus better equipping this nation to deal with the potential use of RNA viruses as biological weapons. [unreadable] [unreadable]..
  60. Dynamics of arenavirus gene expression in vivo
    Jason Botten; Fiscal Year: 2004
    ..Our findings could be applicable to other RNA viruses that cause persistent infection. ..
  61. Recombinant Yellow Fever 17D-Lassa Vaccine
    Igor Lukashevich; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Yellow Fever (YF) and Lassa Fever (LF) are two viral hemorrhagic fevers (VHFs) endemic for West and Central Africa...