aids related opportunistic infections

Summary

Summary: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.

Top Publications

  1. ncbi The growing burden of tuberculosis: global trends and interactions with the HIV epidemic
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, England, UK
    Arch Intern Med 163:1009-21. 2003
  2. ncbi Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project
    C Dye
    Communicable Diseases Prevention and Control, World Health Organization, Geneva, Switzerland
    JAMA 282:677-86. 1999
  3. ncbi Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 19:2109-16. 2005
  4. ncbi Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial
    Annemarie E Brouwer
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 363:1764-7. 2004
  5. ncbi How soon after infection with HIV does the risk of tuberculosis start to increase? A retrospective cohort study in South African gold miners
    Pam Sonnenberg
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    J Infect Dis 191:150-8. 2005
  6. pmc Epidemiology of HIV-associated tuberculosis
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Curr Opin HIV AIDS 4:325-33. 2009
  7. ncbi Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial
    C Chintu
    University Teaching Hospital, Lusaka, Zambia
    Lancet 364:1865-71. 2004
  8. ncbi Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group
    S Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    Clin Infect Dis 31:499-508. 2000
  9. ncbi Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults
    N French
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    AIDS 15:899-906. 2001
  10. pmc Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 8:516-23. 2008

Research Grants

Detail Information

Publications308 found, 100 shown here

  1. ncbi The growing burden of tuberculosis: global trends and interactions with the HIV epidemic
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, England, UK
    Arch Intern Med 163:1009-21. 2003
    ..The increasing global burden of tuberculosis (TB) is linked to human immunodeficiency virus (HIV) infection...
  2. ncbi Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project
    C Dye
    Communicable Diseases Prevention and Control, World Health Organization, Geneva, Switzerland
    JAMA 282:677-86. 1999
    ..To estimate the risk and prevalence of Mycobacterium tuberculosis (MTB) infection and tuberculosis (TB) incidence, prevalence, and mortality, including disease attributable to human immunodeficiency virus (HIV), for 212 countries in 1997...
  3. ncbi Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 19:2109-16. 2005
    ..To determine the long-term incidence of tuberculosis (TB) and associated risk factors among individuals receiving HAART in South Africa...
  4. ncbi Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial
    Annemarie E Brouwer
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 363:1764-7. 2004
    ..We compared the fungicidal activity of combinations of these drugs for initial treatment of patients with cryptococcal meningitis...
  5. ncbi How soon after infection with HIV does the risk of tuberculosis start to increase? A retrospective cohort study in South African gold miners
    Pam Sonnenberg
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    J Infect Dis 191:150-8. 2005
    ..Infection with human immunodeficiency virus (HIV) increases the risk of tuberculosis (TB), but no study has assessed how this risk changes with time since HIV seroconversion...
  6. pmc Epidemiology of HIV-associated tuberculosis
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Curr Opin HIV AIDS 4:325-33. 2009
    ..We review literature concerning the epidemiology of HIV-associated tuberculosis (HIV-TB), focusing on articles published between 2007 and 2008...
  7. ncbi Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial
    C Chintu
    University Teaching Hospital, Lusaka, Zambia
    Lancet 364:1865-71. 2004
    ..We aimed to assess the efficacy of daily co-trimoxazole in such an area...
  8. ncbi Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group
    S Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    Clin Infect Dis 31:499-508. 2000
    ..Resistance to antifungal drugs was uncommon. The epidemiology of CNVN infection has changed substantially. Clinical manifestations of disease are influenced more strongly by host immune status than by cryptococcal variety...
  9. ncbi Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults
    N French
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    AIDS 15:899-906. 2001
    ..Emphasis on mosquito avoidance measures should be an important component of education and counselling of HIV/AIDS patients in malaria-endemic areas, and suggests an additional HIV-related public health problem in Africa...
  10. pmc Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 8:516-23. 2008
    ..It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data...
  11. ncbi Visceral leishmaniasis in those infected with HIV: clinical aspects and other opportunistic infections
    R Russo
    Department of Infectious Diseases, Catania University, Via Passo Gravina 187, 95125 Catania, Italy
    Ann Trop Med Parasitol 97:99-105. 2003
    ..The opportunistic infections that are often seen in HIV-positives frequently develop during VL episodes, the signs and symptoms of the leishmaniasis then confusingly overlapping with those of the other infections...
  12. ncbi Late presentation of HIV-infected individuals
    Manuel Battegay
    Division of Infectious Diseases Et Hospital Epidemiology, University Hospital Basel, Switzerland
    Antivir Ther 12:841-51. 2007
    ....
  13. ncbi Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997
    Francisco Javier San-Andrés
    Medicina Familiar y Comunitaria, Centro de Salud Potes, Guadalajara 19003, Spain
    Clin Infect Dis 36:1177-85. 2003
    ..A reduction in the incidence of AIDS-related ODs was observed, mainly in patients who underwent prophylaxis. Adherence to antiretroviral treatment and PCP prophylaxis was associated with a reduction in the risk of disease...
  14. ncbi Tuberculosis in HIV-infected patients: a comprehensive review
    L Aaron
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Clin Microbiol Infect 10:388-98. 2004
    ..Finally, immune restoration induced by highly active anti-retroviral therapy (HAART) in developed countries may be responsible for a paradoxical worsening of TB manifestations...
  15. ncbi Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome
    Kent A Sepkowitz
    Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA
    Clin Infect Dis 34:1098-107. 2002
    ..Reviewed are 4 common opportunistic infections: Pneumocystis carinii pneumonia, cryptococcosis, atypical mycobacterial infection, and cytomegalovirus infection. Emphasized are the important differences among these groups at risk...
  16. ncbi Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free and University College Medical School of University College London, Royal Free Campus, London, UK
    Lancet 363:2116-21. 2004
    ..We have investigated whether cytomegalovirus viraemia remains a significant risk factor for progression of HIV disease and death in the era of HAART...
  17. ncbi Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment
    Elizabeth L Corbett
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 367:926-37. 2006
    ..Here, we review tuberculosis epidemiology in Africa and policy implications of HIV/AIDS treatment scale-up...
  18. ncbi The impact of HIV-protease inhibitors on opportunistic parasites
    Edoardo Pozio
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Trends Parasitol 21:58-63. 2005
    ....
  19. ncbi Cryptococcosis: population-based multistate active surveillance and risk factors in human immunodeficiency virus-infected persons. Cryptococcal Active Surveillance Group
    R A Hajjeh
    Centers for Disease Control and Prevention, Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, Atlanta, GA 30333, USA
    J Infect Dis 179:449-54. 1999
    ..Further studies are needed to better describe persons with AIDS currently developing cryptococcosis in the era of highly active antiretroviral therapy...
  20. ncbi Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy
    M A Jacobson
    Department of Medicine, University of California, San Francisco 94110, USA
    Lancet 349:1443-5. 1997
    ..In previous natural history studies and clinical trials, AIDS-related cytomegalovirus (CMV) retinitis has occurred primarily in patients with absolute CD4 counts of 50 cells/microL or less (0.05 x 10(9)/L) at the time of diagnosis...
  21. ncbi Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes
    Haileyesus Getahun
    Stop TB Department, WHO, Geneva, Switzerland
    Lancet 369:2042-9. 2007
    ..To achieve these goals, greater political commitment, scientific interest, and investment are needed...
  22. pmc Interventions to reduce tuberculosis mortality and transmission in low- and middle-income countries
    Martien W Borgdorff
    Royal Netherlands Tuberculosis Association, The Hague, The Netherlands
    Bull World Health Organ 80:217-27. 2002
    ....
  23. pmc Subgenotype analysis of Cryptosporidium isolates from humans, cattle, and zoo ruminants in Portugal
    Margarida Alves
    Unidade de Protozoários Oportunistas VIH e Outras Protozooses, Unidade de Parasitologia e Microbiologia Médicas UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349 008 Lisbon, Portugal
    J Clin Microbiol 41:2744-7. 2003
    ..One new allele was found (IId), and one (IIb) had only been found in Portugal. Isolates from cattle and wild ruminants clustered in two alleles. In contrast, human isolates clustered in seven alleles, showing extensive allelic diversity...
  24. ncbi Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 5:361-73. 2005
    ..We also discuss the problem of IRD associated with mycobacterial diseases in developing countries where tuberculosis prevalence is high and access to HAART is currently expanding...
  25. ncbi Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study
    Motasim Badri
    HIV Clinical Research Unit, Somerset Hospital, University of Cape Town, Green Point 8005, Cape Town, South Africa
    Lancet 359:2059-64. 2002
    ..Studies of the effect of highly active antiretroviral therapy (HAART) on the risk of HIV-1-associated tuberculosis have had variable results. We set out to determine the effect of HAART on the risk of tuberculosis in South Africa...
  26. pmc An approach to the problems of diagnosing and treating adult smear-negative pulmonary tuberculosis in high-HIV-prevalence settings in sub-Saharan Africa
    A D Harries
    College of Medicine, Chichiri, Blantyre, Malawi
    Bull World Health Organ 76:651-62. 1998
    ..Nevertheless, substantial improvement could be obtained by implementing the effective measures already available, such as improved adherence to diagnostic and treatment guidelines...
  27. ncbi Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children
    S M Graham
    Department of Paediatrics, College of Medicine, University of Malawi, Blantyre
    Lancet 355:369-73. 2000
    ..We aimed to describe the rate, clinical presentation, and outcome of PCP in young Malawian children with acute severe pneumonia...
  28. pmc Determinants of disease presentation and outcome during cryptococcosis: the CryptoA/D study
    Francoise Dromer
    Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, CNRS URA3042, Institut Pasteur, Paris, France
    PLoS Med 4:e21. 2007
    ....
  29. ncbi HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy
    Jutta K Neuenburg
    Department of Neurology, University of California, San Francisco, USA
    J Acquir Immune Defic Syndr 31:171-7. 2002
    ..Although combination therapies decrease overall mortality and prevalence of CNS opportunistic infections, these therapies may be less active in preventing direct HIV-1 effects on the brain...
  30. ncbi The potential impact of enhanced diagnostic techniques for tuberculosis driven by HIV: a mathematical model
    David W Dowdy
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    AIDS 20:751-62. 2006
    ..To explore the potential impact of enhanced tuberculosis (TB) diagnostic techniques as a TB control strategy in an adult population with high HIV prevalence...
  31. ncbi The high burden of Pneumocystis carinii pneumonia in African HIV-1-infected children hospitalized for severe pneumonia
    Donatella D Ruffini
    Department of Paediatrics, University of the Witwatersrand, Johannesburg 2000, South Africa
    AIDS 16:105-12. 2002
    ..To evaluate the burden of Pneumocystis carinii pneumonia (PCP) and the usefulness of induced sputum and nasopharyngeal aspirates (NPA) in diagnosing PCP in African children in whom the use of bronchoalveolar lavage is unavailable...
  32. pmc Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome
    Alay S Banker
    Banker s Retina Clinic and Laser Centre, 5 Subhash Society, Behind Ishvar Bhuvan, Ahmedabad 380 009, India
    Indian J Ophthalmol 56:377-83. 2008
    ..Immune recovery uveitis is a new cause of vision loss in patients on HAART. Diagnosis and treatment are guided by the particular conditions and immune status of the patient...
  33. ncbi Oropharyngeal carriage of Candida species in HIV-infected patients in India
    H C Gugnani
    Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110 027, India
    Mycoses 46:299-306. 2003
    ..The azole-resistant isolates reported here endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned...
  34. pmc Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients
    S A Spector
    University of California at San Diego, La Jolla, California 92093, USA
    J Clin Invest 101:497-502. 1998
    ..001). These data indicate that the risk of developing CMV disease and death in persons with advanced AIDS is directly related to the quantity of CMV DNA in plasma, and is a better predictor than CD4+ lymphocyte count in this population...
  35. ncbi Gender differences in quality of HIV care in Ryan White CARE Act-funded clinics
    Lisa R Hirschhorn
    Harvard Medical School Division of AIDS, The Landmark Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Womens Health Issues 16:104-12. 2006
    ..We examined differences in care received by HIV-infected women and men in a national sample of Ryan White CARE Act-funded clinics and explored the influence of clinic characteristics on care quality...
  36. ncbi Leishmania/HIV co-infection in Brazil: an appraisal
    A Rabello
    Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, FIOCRUZ, Avenida, Augusto de Lima, 1715, 30190 002 Belo Horizonte, Minas Gerais, Brazil
    Ann Trop Med Parasitol 97:17-28. 2003
    ....
  37. ncbi Effect of simultaneous use of highly active antiretroviral therapy on survival of HIV patients with tuberculosis
    Maria Velasco
    Infectious Diseases Section, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Spain
    J Acquir Immune Defic Syndr 50:148-52. 2009
    ..To assess the effect of HAART on the survival of patients with TB, we designed this study...
  38. ncbi CD4 decline and incidence of opportunistic infections in Cape Town, South Africa: implications for prophylaxis and treatment
    Charles B Holmes
    Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 42:464-9. 2006
    ..To determine the rate of CD4 decline and the incidence of opportunistic infections (OIs) among antiretroviral therapy-naive South African HIV-infected patients and inform timing of OI prophylaxis...
  39. ncbi Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy
    Samuel A Shelburne
    Department of Medicine, Section of Infectious Diseases, University of Texas Health Science Center at Houston, Texas 77030 4211, USA
    AIDS 19:399-406. 2005
    ..There is little systematic information regarding the immune reconstitution inflammatory syndrome (IRIS)...
  40. pmc Antiretroviral therapy for control of the HIV-associated tuberculosis epidemic in resource-limited settings
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Clin Chest Med 30:685-99, viii. 2009
    ..This article provides an in-depth review of these issues...
  41. ncbi HIV and tuberculosis coinfection in the southern region of Ethiopia: a prospective epidemiological study
    Mohammed Ahmed Yassin
    Southern Region Health Bureau, Awassa, Ethiopia
    Scand J Infect Dis 36:670-3. 2004
    ..It is important to consider this multi-factorial phenomenon when interpreting the increase of TB in a geographical area...
  42. ncbi Prevalence, incidence and mortality associated with tuberculosis in HIV-infected patients initiating antiretroviral therapy in rural Uganda
    David Moore
    Global AIDS Program, Us centers for Disease Control and Prevention CDC, Entebbe, Uganda
    AIDS 21:713-9. 2007
    ..Tuberculosis (TB) is the leading cause of death among people with HIV in sub-Saharan Africa. Expanding access to antiretroviral therapy (ART) may reduce the burden of TB, but to what extent is unknown...
  43. ncbi Histoplasmosis
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Infect Dis Clin North Am 17:1-19, vii. 2003
    ..This article provides an up-to-date clinical review of histoplasmosis, focusing on recognition, diagnosis, and management...
  44. ncbi Cytomegalovirus (CMV) and human immunodeficiency virus (HIV) burden, CMV end-organ disease, and survival in subjects with advanced HIV infection (AIDS Clinical Trials Group Protocol 360)
    A Erice
    University of Minnesota, MN, USA
    Clin Infect Dis 37:567-78. 2003
    ..HIV-infected subjects with CD4 cell counts of < or =50 cells/mm3 and HIV RNA levels of >10,000 copies/mL of plasma should have blood fractions screened for CMV DNA; if CMV DNA is detected, CMV prophylaxis might be considered...
  45. ncbi Comparison of two versus three smears in identifying culture-positive tuberculosis patients in a rural African setting with high HIV prevalence
    A C Crampin
    Karonga Prevention Study, Chilumba, Malawi
    Int J Tuberc Lung Dis 5:994-9. 2001
    ..The potential for improving specificity is important because of the costs of misdiagnosis. In practice, both sensitivity and specificity may be increased due to the time saved by examining two rather than three smears...
  46. pmc Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 23:1717-25. 2009
    ..To determine the short-term and long-term risks of tuberculosis (TB) associated with CD4 cell recovery during antiretroviral therapy (ART)...
  47. ncbi Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons
    Vitaliano A Cama
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, US Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 196:684-91. 2007
    ..parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations...
  48. ncbi Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy
    Janet T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room W5010, Baltimore, MD 21205, USA
    Arch Ophthalmol 121:99-107. 2003
    ..To evaluate rates and causes of visual loss among patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis before widespread availability of highly active antiretroviral therapy (HAART)...
  49. ncbi Towards universal access to HIV prevention, treatment, care, and support: the role of tuberculosis/HIV collaboration
    Alasdair Reid
    Stop TB Department, WHO, Geneva, Switzerland
    Lancet Infect Dis 6:483-95. 2006
    ....
  50. ncbi Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study
    V Pintado
    Clinical Microbiology-Infectious Diseases Department, , Universidad Complutense, Madrid, Spain
    Medicine (Baltimore) 80:54-73. 2001
    ..Visceral leishmaniasis behaves as an opportunistic infection in HIV-infected individuals and should be considered as an AIDS-defining disease...
  51. ncbi Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen. ACTG 375 team. AIDS Clinical Trials Group
    H Valdez
    Division of Infectious Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Ohio 44106, USA
    AIDS 14:11-21. 2000
    ....
  52. ncbi Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda
    Jonathan Mermin
    CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, National Center for Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 364:1428-34. 2004
    ..We assessed the effect of such prophylaxis on morbidity, mortality, CD4-cell count, and viral load among people with HIV infection living in rural Uganda, an area with high rates of bacterial resistance to co-trimoxazole...
  53. pmc The relationship between leishmaniasis and AIDS: the second 10 years
    Jorge Alvar
    Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Clin Microbiol Rev 21:334-59, table of contents. 2008
    ..Based on the previous experience of 20 years of coinfection in Europe, this review focuses on the management of Leishmania-HIV-coinfected patients in low-income countries where leishmaniasis is endemic...
  54. ncbi The role of HSV in the transmission and progression of HIV
    T Schacker
    Department of Medicine, University of Minnesota, Division of Infectious Diseases, Box 250, 516 Delaware Street, Minneapolis, MN 55055, USA
    Herpes 8:46-9. 2001
    ....
  55. ncbi Trends in mortality from pulmonary tuberculosis and HIV/AIDS co-infection in rural South Africa (Agincourt)
    Julien Zwang
    ISD IRD, Institut Biomedical des Cordeliers, Universite Paris 6, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Trans R Soc Trop Med Hyg 101:893-8. 2007
    ..001). Combined PTB and HIV programme activities need to be reinforced to respond to the increase in PTB mortality, particularly in women...
  56. ncbi Pathology and causes of death in a series of human immunodeficiency virus-positive and -negative pediatric referral hospital admissions in Botswana
    Naseem A Ansari
    BOTUSA Project, Gaborone, Botswana
    Pediatr Infect Dis J 22:43-7. 2003
    ..Little is known about causes of death among children seriously affected by the AIDS epidemic in southern African countries...
  57. ncbi Impact of human immunodeficiency virus 1 infection on clinical presentation, treatment outcome and survival in a cohort of Ethiopian children with tuberculosis
    Ingel Berggren Palme
    Unit for Infectious Disease Epidemiology, Microbiology and Tumor Biology Centre, Karolinska Institutet, Solna, Sweden
    Pediatr Infect Dis J 21:1053-61. 2002
    ..This study examines the impact of HIV infection on clinical presentation, diagnostic criteria and treatment outcome of TB in Ethiopian children...
  58. ncbi Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis
    John H Kempen
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 113:684-94. 2006
    ..To evaluate the prevalence of and risk factors for immune recovery uveitis (IRU) in eyes of patients with AIDS and cytomegalovirus (CMV) retinitis...
  59. ncbi Ocular tuberculosis in acquired immunodeficiency syndrome
    Rajesh B Babu
    Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India
    Am J Ophthalmol 142:413-8. 2006
    ..To present the clinical, histopathological, and molecular biologic findings in fifteen cases of ocular tuberculosis (TB) in patients with acquired immune deficiency syndrome (AIDS)...
  60. ncbi Epidemiology of HIV-associated cryptococcosis in France (1985-2001): comparison of the pre- and post-HAART eras
    Francoise Dromer
    AIDS 18:555-62. 2004
    ..To analyse the epidemiological evolution of cryptococcosis in France after the introduction of highly active antiretroviral therapy (HAART)...
  61. ncbi Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis
    Guillaume Breton
    Department of Infectious and Tropical Diseases, Hopital Bichat Claude Bernard, Paris, France
    AIDS 20:119-21. 2006
    ..Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome...
  62. ncbi Treatment of HIV-1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapy
    A Carr
    HIV Medicine Unit and Centre for Immunology, St Vincent s Hospital, Sydney, Australia
    Lancet 351:256-61. 1998
    ..HIV-1 protease inhibitors are more effective across a broader range of HIV-1-infected immune cells. Combination antiretroviral therapy that includes a protease inhibitor could improve immunity to E bieneusi and C parvum...
  63. ncbi The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART)in a London clinic
    N J Ives
    Academic Department of HIV/GU Medicine, The Guy's, King's and St. Thomas' School of Medicine, Weston Education Centre, King's College Hospital, Cutcombe Road, London, SE5 9RT, UK
    J Infect 42:134-9. 2001
    ..The non-significant increase in the incidence of NHL and tuberculosis needs confirmation in other patient cohorts...
  64. ncbi Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998
    N A Ansari
    The BOTUSA Project, Gaborone, Botswana
    Int J Tuberc Lung Dis 6:55-63. 2002
    ..Little is known about causes of death in countries of southern Africa seriously affected by the HIV/AIDS epidemic...
  65. ncbi Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy
    P Price
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, GPO X2213, Perth, WA 6001, Australia
    J Clin Virol 22:279-87. 2001
    ..We defined these conditions as immune restoration diseases (IRD) and showed that they occur in 30-40% of individuals who begin HAART from low CD4 T cell counts...
  66. ncbi Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendations
    M Badri
    Infectious Diseases Clinical Research Unit, Lung Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    AIDS 15:1143-8. 2001
    ..Further studies are needed to assess the optimal time of commencement of prophylaxis, as widespread co-trimoxazole use will lead to increasing antimicrobial resistance to other major pathogens in Africa...
  67. pmc HIV care and treatment factors associated with improved survival during TB treatment in Thailand: an observational study
    Jay K Varma
    U S Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Infect Dis 9:42. 2009
    ....
  68. ncbi Strongyloidiasis in an HIV-1-infected patient after highly active antiretroviral therapy-induced immune restoration
    Massimiliano Lanzafame
    J Infect Dis 191:1027. 2005
  69. ncbi Disclosure of HIV status and adherence to daily drug regimens among HIV-infected children in Uganda
    Winnie Bikaako-Kajura
    CDC Uganda, Global AIDS Program, Kampala, Uganda
    AIDS Behav 10:S85-93. 2006
    ....
  70. ncbi Clinical features of microsporidiosis in patients with AIDS
    D M Asmuth
    Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts 02215
    Clin Infect Dis 18:819-25. 1994
    ..We also recommend that special attention be paid to the measurement of parameters of absorption with appropriate modification of diet...
  71. ncbi Autopsy-proven determinants of death in HIV-infected patients treated for pulmonary tuberculosis in Sao Paulo, Brazil
    Eliana Battaggia Gutierrez
    Division of Infectious Diseases, Hospital das Clinicas, School of Medicine, University of Sao Paulo, Brazil
    Pathol Res Pract 198:339-46. 2002
    ..Early treatment for tuberculosis and associated diseases can improve survival and the quality of life even of highly immunosuppressed patients...
  72. ncbi The pathogenesis of Leishmania/HIV co-infection: cellular and immunological mechanisms
    M Olivier
    Faculty of Medicine, McGill University, Lyman Duff Medical Building, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada
    Ann Trop Med Parasitol 97:79-98. 2003
    ..An overview of the recent findings concerning this Leishmania/HIV-1 interaction is presented here...
  73. ncbi Trends in tuberculosis and the influence of HIV infection in northern Malawi, 1988-2001
    Judith R Glynn
    London School of Hygiene and Tropical Medicine, UK
    AIDS 18:1459-63. 2004
    ..To document the changing incidence and patterns of tuberculosis (TB) in rural Africa and the extent to which they are influenced by HIV...
  74. ncbi Leishmania/HIV co-infections: epidemiology in Europe
    P Desjeux
    Strategy Development and Monitoring of Zoonoses, Foodborne Diseases and Kinetoplastidae, Department of Control, Prevention and Eradication ZFK CPE, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Ann Trop Med Parasitol 97:3-15. 2003
    ..The parasites and HIV may also be transmitted as the result of needle-sharing among intravenous-drug users...
  75. pmc Colonization of human immunodeficiency virus-infected outpatients in Taiwan with Candida species
    Chien Ching Hung
    Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Microbiol 43:1600-3. 2005
    ....
  76. ncbi Conventional tuberculin skin testing versus T-cell-based assays in the diagnosis of latent tuberculosis infection in HIV-positive patients
    Matthias Hoffmann
    AIDS 21:390-2. 2007
  77. pmc Cryptosporidium felis and C. meleagridis in persons with HIV, Portugal
    Olga Matos
    Emerg Infect Dis 10:2256-7. 2004
  78. ncbi [Human cryptosporidiosis and Cryptosporidium spp. in Haiti]
    Christian P Raccurt
    Service de Parasitologie et de Mycologie médicales, Faculté de Médecine et CHU d Amiens, Universite de Picardie Jules Verne, Amiens, France
    Trop Med Int Health 11:929-34. 2006
    ..Cryptosporidiosis remains a frequent hazard for both AIDS patients and young children in Haiti because of poor hygiene, particularly contaminated water and overcrowded conditions associated with urban slums...
  79. ncbi Aetiology of prolonged fever in antiretroviral-naïve human immunodeficiency virus-infected adults
    Priscilla Rupali
    Department of General Medicine Unit I and Infectious Diseases, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India
    Natl Med J India 16:193-9. 2003
    ..In this paper, we have profiled the causes of prolonged fever in a cohort of HIV-infected Indian patients and have developed suitable algorithms to assist in an early diagnosis...
  80. pmc Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome
    Jyotirmay Biswas
    Sankara Nethralaya, 18, College Road, Chennai 600 006, India
    Indian J Ophthalmol 56:363-75. 2008
    ..This article is a comprehensive update of the important anterior segment and adnexal manifestations in HIV-positive patients with special reference to their prevalence in the Indian population...
  81. ncbi Paradoxical responses in a cohort of HIV-1-infected patients with mycobacterial disease
    J Olalla
    Unidad de Infección VIH, Servicio de Medicina Interna, Hospital Universitario Doce de Octubre, Madrid, Spain
    Int J Tuberc Lung Dis 6:71-5. 2002
    ..Paradoxical worsening or relapse of opportunistic infections has been described after initiation of highly active anti-retroviral therapy (HAART) in human immunodeficiency virus (HIV) infected patients...
  82. ncbi Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
    Jacqueline Ferreira de Oliveira
    Minas Gerais Hospital State Foundation, Hospital Eduardo de Menezes, Belo Horizonte, MG, Brazil
    Rev Soc Bras Med Trop 39:146-51. 2006
    ..The neurological diseases continue to be a frequent complication of HIV/AIDS and infections are still its main causes in Brazil, even in the highly active antiretroviral treatment era...
  83. ncbi CNS manifestations of cytomegalovirus infections: diagnosis and treatment
    Matthias Maschke
    Department of Neurology, University Clinic of Essen, Germany
    CNS Drugs 16:303-15. 2002
    ..Despite therapy, the prognosis for long-term survival is very poor, especially in patients with AIDS...
  84. ncbi Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients
    Anne Bourgarit
    Laboratory of Cellular Immunology, Pitie Salpetriere Hospital, Universite Pierre et Marie Curie, Paris, France
    AIDS 20:F1-7. 2006
    ..To test the hypothesis that an acute exacerbation of mycobacteria-specific Th1 response after HIV infection control by HAART causes immune restoration syndrome (IRS) in HIV-tuberculosis (TB) coinfected patients...
  85. ncbi Cryptococcus neoformans infection in a cohort of Italian AIDS patients: natural history, early prognostic parameters, and autopsy findings
    S Antinori
    Department of Infectious and Tropical Diseases, L Sacco Hospital, University of Milan, Italy
    Eur J Clin Microbiol Infect Dis 20:711-7. 2001
    ..Cryptococcosis relapsed in 12.8% of patients on secondary prophylaxis. Autopsy findings demonstrated that cryptococcosis is a disseminated disease, but long-term antifungal treatment may be able to eradicate it in a subgroup of patients...
  86. ncbi Immune reconstitution inflammatory syndrome of tuberculosis among HIV-infected patients receiving antituberculous and antiretroviral therapy
    Weerawat Manosuthi
    Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Tiwanon Road, Nonthaburi 11000, Thailand
    J Infect 53:357-63. 2006
    ..To determine the frequency, risk factors and mortality rate of immune reconstitution inflammatory syndrome (IRIS) of tuberculosis (TB) in patients co-infected with HIV/TB and receiving antiretroviral therapy (ART)...
  87. ncbi Bacillary angiomatosis with cytomegaloviral and mycobacterial infections of the palpebral conjunctiva in a patient with AIDS
    Brenda C Edmonson
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Ophthal Plast Reconstr Surg 20:168-70. 2004
    ..Acid-fast bacilli were also found in the excised tissue. Patients with bacillary angiomatosis of the conjunctiva may have infections with multiple additional microorganisms...
  88. ncbi Rolling out antiretrovirals in Africa: there are still challenges ahead
    R Colebunders
    Clin Infect Dis 41:386-9. 2005
  89. ncbi Pulmonary complications of human immunodeficiency virus infection in Bujumbura, Burundi
    G Kamanfu
    Department of Medicine, University of Bujumbura School of Medicine, Burundi
    Am Rev Respir Dis 147:658-63. 1993
    ....
  90. ncbi Impact of tuberculosis on HIV-1 replication, diversity, and disease progression
    Kalonji R Collins
    Molecular Virology Program, Case Western Reserve University, Biomedical Research Building 10th, 2109 Adelbert Rd, Cleveland, OH 44106 4984, USA
    AIDS Rev 4:165-76. 2002
    ..The HIV-1 found in blood following this TB-mediated burst in load and diversity appear to be phylogenetically-related to HIV-1 clones that have evolved independently in the lung or pleural compartments, now infected by M. tuberculosis...
  91. ncbi Predicting the evolution of Kaposi sarcoma, in the highly active antiretroviral therapy era
    Emmanuelle Boffi El Amari
    Geneva University Hospital, Geneva, Switzerland
    AIDS 22:1019-28. 2008
    ..While many patients do well on highly active antiretroviral therapy, others have progressive disease and need chemotherapy. In order to predict which patients are at risk of unfavorable evolution, we established a prognostic score...
  92. ncbi Tuberculosis and HIV interaction in sub-Saharan Africa: impact on patients and programmes; implications for policies
    Dermot Maher
    Stop TB, World Health Organization, Geneva, Switzerland
    Trop Med Int Health 10:734-42. 2005
    ..This can help to ensure a firm evidence base for TB control policies aiming at the high standard of patient care that is at the heart of TB and HIV programmes...
  93. ncbi Disseminated Penicillium marneffei infection among HIV-infected patients in Manipur state, India
    K H Ranjana
    Department of Microbiology, J N Medical Hospital, Imphal 795001, Manipur, India
    J Infect 45:268-71. 2002
    ..To further describe the clinical and epidemiological characteristics of Penicillium marneffei infection in human immunodeficiency virus (HIV) infected patients in India...
  94. ncbi Risk factors for active tuberculosis after antiretroviral treatment initiation in Abidjan
    Catherine Seyler
    INSERM U593, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Am J Respir Crit Care Med 172:123-7. 2005
    ....
  95. ncbi Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, Vietnam
    H T Quy
    Pham Ngoc Thach TB and Lung Disease Hospital, Ho Chi Minh City, Vietnam
    Int J Tuberc Lung Dis 10:45-51. 2006
    ..To assess the combined effects of drug resistance, HIV infection and treatment regimen on treatment outcomes of smear-positive tuberculosis patients in Ho Chi Minh City, Vietnam...
  96. ncbi Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:780-6. 2007
    ..To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART)...
  97. ncbi Nosocomial transmission of Mycobacterium bovis resistant to 11 drugs in people with advanced HIV-1 infection
    A Guerrero
    Infectious Disease and Clinical Microbiology Department, Hospital Ramon y Cajal, Universidad de Alcala de Henares, Madrid, Spain
    Lancet 350:1738-42. 1997
    ..We describe an epidemic of nosocomial and primary MDR M bovis tuberculosis from December, 1993, to February, 1995, among HIV-1-infected patients in a district of Madrid...
  98. ncbi Prevalence of intestinal parasitic pathogens in HIV-seropositive individuals in Northern India
    - Mohandas
    Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Jpn J Infect Dis 55:83-4. 2002
    ....
  99. ncbi Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi
    Rony Zachariah
    Medecins Sans Frontieres, Operational Research, Brussels Operational Center, Belgium
    AIDS 20:2355-60. 2006
    ....
  100. ncbi Cryptosporidiosis and microsporidiosis in ugandan children with persistent diarrhea with and without concurrent infection with the human immunodeficiency virus
    James K Tumwine
    Department of Paediatrics and Child Health, Mulago Hospital, Makerere University Medical School, Kampala, Uganda
    Am J Trop Med Hyg 73:921-5. 2005
    ..Seventy-four percent of isolates were C. hominis, the anthroponotic species, 17% were C. parvum, the zoonotic species, and 8% were a mixture of the two or others...

Research Grants62

  1. Trial for the Optimal Timing of HIV Therapy after Cryptococcal Meningitis
    David R Boulware; Fiscal Year: 2013
    ..The optimal time to start HIV therapy is unknown. This is a definitive strategy trial to determine if early initiation of HIV therapy while hospitalized results in superior long term survival. ..
  2. PROTEINS OF CANDIDA ALBICANS AN AIDS-RELATED PATHOGEN
    Paula Sundstrom; Fiscal Year: 1993
    ..albicans via chemical crosslinking. Finally, studies to identify potential targets for anti-fungal therapy will be initiated by mapping adherent as welll as immunodominant domains on the protein...
  3. ORAL BIOAVAILABILITY AND VARIABILITY OF ANTIAIDS DRUGS
    Patrick Sinko; Fiscal Year: 2000
    ....
  4. Structure Biology and Targeted Drug Design for AIDS
    Paul Ortiz de Montellano; Fiscal Year: 2006
    ....
  5. NOVEL PRODRUGS FOR TREATMENT OF OPPORTUNISTIC INFECTIONS
    James Allen; Fiscal Year: 2001
    ..The immediate goal is to apply for FDA approval to begin human clinical trials as an orally active agent to treat P. carinii pneumonia. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  6. NEW BROAD SPECTRUM DRUGS FOR OPPORTUNISTIC INFECTIONS
    Lawrence Potempa; Fiscal Year: 2000
    ..The development of any drug clinically active against Cryptosporidiosis is particularly needed. ..
  7. Beckman Coulter BioMek 2000 Workstation and Accessories
    Joseph McCune; Fiscal Year: 2002
    ..abstract_text> ..
  8. DEVELOPMENT OF A HAWAII AIDS CLINICAL TRIALS UNIT
    MARGO HEATH CHIOZZI; Fiscal Year: 1992
    ....
  9. ADULT AIDS CLINICAL TRIALS UNIT
    Diane Havlir; Fiscal Year: 2006
    ..Dr. J. M. McCune will provide expertise and laboratory support for immunologic studies, and Drs. Richard Price and Harry Hollander will provide clinical expertise to support neurologic studies. ..
  10. ANTIGENURIA--EXPERIMENTAL & HUMAN MYCOBACTERIAL INFECT
    Robert Wallis; Fiscal Year: 2000
    ..This project may ultimately lead to the development of a novel assay which can be used clinically for diagnosis and management of latent and active mycobacterial infection in AIDS. ..
  11. ANTI AIDS AGENTS FROM MARINE ORGANISMS
    Mark Hamann; Fiscal Year: 1999
    ..Additional quantities of particularly promising compounds that are required for in vivo testing will be obtained via synthesis, semi-synthesis, or repeated isolation. ..
  12. INTERFERON, THE BLOOD-BRAIN-BARRIER AND GLIOMA
    Marzenna Wiranowska; Fiscal Year: 1992
    ..more effective ways of treating brain tumors, the protocols may also have utility in treating AIDS related opportunistic infections of the brain...
  13. IMPROVING HEALTH CARE UTILIZATION IN HIV+ DRUG USERS
    Kelly Gebo; Fiscal Year: 2005
    ..Gebo the skills she needs to develop into an independent clinician researcher in HIV epidemiologic and health services research. ..
  14. CLINICAL OUTCOMES IN ELDERLY HIV PATIENTS
    Kelly Gebo; Fiscal Year: 2007
    ..abstract_text> ..
  15. Molecular Epidemiology of Human P. carinii Pneumonia
    Laurence Huang; Fiscal Year: 2006
    ..abstract_text> ..
  16. Effects of HLA and KIR genotype on HIV and HCV
    Howard Strickler; Fiscal Year: 2006
    ..WlHS is a large, racially and geographically diverse cohort of HIV(+) (n=2761 with - 40% HCV(+)), and HIV(-) women who share similar risk factors (n=942 with - 25%HCV(+)). ..
  17. Studies on Cryptosporidium parvum Type 1
    Saul Tzipori; Fiscal Year: 2006
    ..The third aim investigates the extent of genetic variation and exchange within and between the two types of C. parvum to determine whether they belong to one or two species. ..
  18. Impact of HIV-related infections and ART in South Africa
    Charles Holmes; Fiscal Year: 2006
    ..He is mentored by two senior investigators with an extremely strong record of mentoring junior investigators and guiding them to become successful physician scientists. ..
  19. HCV Treatment Cost-Effectiveness in 3 IDU Populations
    BRUCE SCHACKMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  20. ADULT AIDS CLINICAL TRIALS UNIT
    Mitchell Goldman; Fiscal Year: 2008
    ..Specialized immunology, virology, and pharmacology laboratories will support this work. ..
  21. COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNIT
    Scott Hammer; Fiscal Year: 2006
    ..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..
  22. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..abstract_text> ..
  23. Targeted DNA extraction for Tuberculosis PCR from sputum
    Eric Houpt; Fiscal Year: 2007
    ..The most sensitive procedure will be taken in Phase II and adapted to high-throughput DNA extraction platforms and compared against the standard E- MTD assay. [unreadable] [unreadable] [unreadable]..
  24. CRYPTOCOCCUS NEOFORMANS--A MODEL FOR PATHOGENIC FUNGI
    John Perfect; Fiscal Year: 2003
    ..This program emphasizes a focus on a single pathogen with a basic but broad-spectrum and highly interactive genomic approach to scientific investigations which can be extrapolated to other fungi. ..
  25. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..3. To characterize the T-cell dysfunction of patients with active pulmonary tuberculosis, its relationship to TGF-beta and other suppressive cytokines (IL-10) and its reversal by inhibitors of TGF- beta. ..
  26. Generation of Reagents for E. bieneusi Genome Sequencing
    Saul Tzipori; Fiscal Year: 2003
    ..The outcome of this proposal will lead to a submission of a full proposal to sequence the EB genome. ..
  27. QUALITY OF LIFE AND COST EFFECTIVENESS IN CMV RETINITIS
    John Kempen; Fiscal Year: 2002
    ..Subanalyses will assess what factors other than treatment strategy are associated with improved QOL and cost-effectiveness. ..
  28. GENETIC & MOLECULAR BIOLOGY OF VIRULENCE IN C NEOFORMANS
    John Perfect; Fiscal Year: 2004
    ..It is our hypothesis that beginning to understand the genetic regulation of C. neoformans during infection through this proposal will be a powerful tool to find targets to interrupt pathogenesis. ..
  29. EBV and HPV: Oral Infection, Persistence & Pathogenesis
    DENNIS WALLING; Fiscal Year: 2003
    ..abstract_text> ..
  30. Multiplex bead-PCR diagnosis for AIDS diarrhea
    Eric Houpt; Fiscal Year: 2007
    ..Finally, syndrome-based multiplex diagnosis is the platform of the future for clinical microbiology, and if this assay works on stool it should work on sputum, blood, or spinal fluid. [unreadable] [unreadable] [unreadable]..
  31. Anal HPV Infection and ASIL in HIV+ and HIV- Women
    Joel Palefsky; Fiscal Year: 2006
    ..Knowledge of genes involved in ASIL pathogenesis may provide new approaches to therapy of both anal and cervical HSIL as well as markers for disease progression. ..
  32. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..This study will test if DNA- fingerprinting of special mouthwashes can accurately diagnose HIV-related pneumonia, and save lives. [unreadable] [unreadable] [unreadable]..
  33. IMMUNITY TO CRYPTOSPORIDIOSIS IN SIV INFECTED MACAQUES
    Saul Tzipori; Fiscal Year: 2002
    ..An understanding of this mechanism is important for the derivation of immunotherapeutic strategies that may be necessary to control chronic cryptosporidiosis in patients with AIDS. ..
  34. PIG MODEL FOR E BIENEUSI
    Saul Tzipori; Fiscal Year: 2002
    ..Given the cost and nature of the simian SIV model it is unlikely this model would serve the same function. ..
  35. Protective immunity induced by newborn BCG vaccination
    Willem Hanekom; Fiscal Year: 2009
    ..We will characterize this response in newborns vaccinated with BCG. We will compare the antibody response between BCG-vaccinated infants who are protected against TB, and those not protected. ..
  36. Insulin-like growth factor axis influence on HIV and HPV pathogenesis in women
    Howard Strickler; Fiscal Year: 2008
    ..abstract_text> ..
  37. Mouse Strain dependent innate resistance to intestinal amebiasis
    Eric Houpt; Fiscal Year: 2009
    ....
  38. Innate immunity and dendritic cells in cryptosporidiosis
    SAUL R TZIPORI; Fiscal Year: 2010
    ..The proposed studies will provide the basis for understanding the mechanisms of innate immune recognition and response to parasite invasion necessary for future design of vaccines and other methods of interventions. ..
  39. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2010
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
  40. Insulin and IGF In female colon, breast, uterine cancer
    Howard Strickler; Fiscal Year: 2005
    ....
  41. Real-time PCR diagnostic kit for Giardia and Cryptosporidium
    Eric Houpt; Fiscal Year: 2006
    ..A Phase II application is anticipated to validate the final diagnostic test product against immunoassay for an FDA 501 (k) medical device application. [unreadable] [unreadable] [unreadable]..
  42. NATURAL HISTORY OF ANAL NEOPLASIA IN HIV INFECTED MEN
    Joel Palefsky; Fiscal Year: 2002
    ....
  43. RECOMBINANT SHIGA-TOXIN-SPECIFIC HUMAN ANTIBODIES
    Saul Tzipori; Fiscal Year: 2004
    ..abstract_text> ..
  44. EBV PATHOGENESIS IN HIV-ASSOCIATED HAIRY LEUKOPLAKIA
    DENNIS WALLING; Fiscal Year: 2003
    ..The results of this study will elucidate molecular mechanisms of EBV pathogenesis in HLP applicable to other EBV-associated diseases, including nasopharyngeal carcinoma and HIV-associated lymphomas. ..
  45. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  46. Modeling Sequential Antiretroviral Therapy in HIV
    Elena Losina; Fiscal Year: 2005
    ..This award will provide critical insight into the optimal strategies for managing HIV infection and will provide Dr. Losina with a solid foundation for development as an independent and productive investigator. ..
  47. Specific Human Monoclonal Antibodies for HUS Prophylaxis
    Saul Tzipori; Fiscal Year: 2007
    ..This is not a hypothesis-driven proposal, but an essential segment for the characterization of a promising therapy for HUS, against which currently there is no effective treatment. ..
  48. Mucosal immune regulation in murine amebic colitis
    Eric Houpt; Fiscal Year: 2007
    ..The comprehensive approach in training and research laid out in this research proposal will guide the applicant towards his goal of being an independent investigator in immunoparasitology. ..
  49. BIOMARKERS FOR ANAL CANCER
    Stephen Hawes; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Impact of efavirenz resistance mutations on HIV-1
    Christine Koval; Fiscal Year: 2006
    ..abstract_text> ..
  51. Macrophages, HAART, and HIV dementia in Thailand
    Victor Valcour; Fiscal Year: 2006
    ..Given this unique cohort, we further intend to use proteomics to generate important molecular markers that predict M/M/phi response to HAART and that distinguish HAD in HAART-treated compared to HAART-naive individuals. ..
  52. Hepatoxicity in an African HIV Treatment Cohort
    Christopher Hoffmann; Fiscal Year: 2008
    ..It will be conducted within a large and on-going ARV cohort established as a collaborative project between a South African industrial conglomerate and Johns Hopkins University. [unreadable] [unreadable]..
  53. STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENES
    James Stringer; Fiscal Year: 2009
    ..abstract_text> ..
  54. Partners in Health and Housing Prevention Research Cent*
    C Horsburgh; Fiscal Year: 2008
    ..Abstract not provided ..
  55. OCULAR IMMUNOPATHOLOGY IN AUTOIMMUNE MODELS
    DOUGLAS JABS; Fiscal Year: 2001
    ....
  56. HIV PREVENTION TRIAL UNITS
    Kenneth Mayer; Fiscal Year: 2007
    ..We will continue our leadership work in community education and the engagement of diverse communities in HIV prevention initiatives. ( ..
  57. Estimation Models for HIV/AIDS in China
    Sten Vermund; Fiscal Year: 2006
    ..We intend to use the findings to help the China CDC establishing a better estimation model for HIV/AIDS. [unreadable] [unreadable] [unreadable]..
  58. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
    ..It may also make it possible to develop a safer and more efficacious vaccine. ..
  59. Families and HIV-risk among girls in psychiatric care
    Geri Donenberg; Fiscal Year: 2007
    ..This study is part of an overall program of research designed to develop effective HIV prevention programs for troubled teens and their families. ..