opportunistic infections

Summary

Summary: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Top Publications

  1. ncbi Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus
    S Ascioglu
    Clin Infect Dis 34:7-14. 2002
  2. ncbi Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections
    Philipp Schütt
    Department of Internal Medicine Cancer Research, West German Cancer Center, University of Duisburg Essen Medical School, Essen, Germany
    Leuk Lymphoma 47:1570-82. 2006
  3. pmc Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections
    Elina I Zuniga
    Department of Immunology and Microbial Sciences, Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 4:374-86. 2008
  4. pmc Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry
    J D Greenberg
    New York University Hospital for Joint Diseases, New York, USA
    Ann Rheum Dis 69:380-6. 2010
  5. doi Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literature
    T Kampitak
    Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Infection 39:65-71. 2011
  6. doi Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis
    N Viget
    Service des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, France
    Gut 57:549-58. 2008
  7. ncbi The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting
    P Lewis White
    Department of Medical Microbiology, National Public Health Service, Cardiff, United Kingdom
    Clin Infect Dis 42:479-86. 2006
  8. ncbi Lessons learned about opportunistic infections in southeast Asia
    Veeranoot Nissapatorn
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 39:625-41. 2008
  9. ncbi [Collagen diseases with opportunistic infections]
    Katsuhiko Takabayashi
    Department of Medical Informatics and Management, Chiba University Hospital
    Nihon Rinsho Meneki Gakkai Kaishi 27:156-63. 2004
  10. pmc Single time point immune function assay (ImmuKnow) testing does not aid in the prediction of future opportunistic infections or acute rejection
    Janna Huskey
    Transplant Center, Department of Pediatrics, University of Colorado, Denver, CO, USA
    Clin J Am Soc Nephrol 6:423-9. 2011

Research Grants

  1. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
  2. MECHANISM-BASED DRUG SELECTION AND DESIGN: NUCLEOTIDE SA
    Buddy Ullman; Fiscal Year: 2003
  3. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
  4. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
  5. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
  6. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
  7. Charles J Smith; Fiscal Year: 2014
  8. International Workshop on Opportunistic Protists (IWOP-12, 13 and 14)
    Louis M Weiss; Fiscal Year: 2012
  9. A Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
    Courtney C Aldrich; Fiscal Year: 2012
  10. JOHN JAMES LETTERIO; Fiscal Year: 2016

Detail Information

Publications302 found, 100 shown here

  1. ncbi Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus
    S Ascioglu
    Clin Infect Dis 34:7-14. 2002
    ..quot; The definitions are intended for use in the context of clinical and/or epidemiological research, not for clinical decision making...
  2. ncbi Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections
    Philipp Schütt
    Department of Internal Medicine Cancer Research, West German Cancer Center, University of Duisburg Essen Medical School, Essen, Germany
    Leuk Lymphoma 47:1570-82. 2006
    ..and humoral immune parameters in myeloma patients, focusing on the effect of treatment and the risk of opportunistic infections. Peripheral blood lymphocyte subsets and serum levels of nonmyeloma immunoglobulins (Ig) were analysed in ..
  3. pmc Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections
    Elina I Zuniga
    Department of Immunology and Microbial Sciences, Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 4:374-86. 2008
    ..between virus-induced impairment in type I interferon (IFN-I) production and enhanced susceptibility to opportunistic infections, which represent a major health problem...
  4. pmc Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry
    J D Greenberg
    New York University Hospital for Joint Diseases, New York, USA
    Ann Rheum Dis 69:380-6. 2010
    To examine the association of methotrexate (MTX) and tumour necrosis factor (TNF) antagonists with the risk of infectious outcomes including opportunistic infections in patients with rheumatoid arthritis (RA).
  5. doi Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literature
    T Kampitak
    Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Infection 39:65-71. 2011
    ..Two patients also developed Sweet's syndrome during the course of infections. In addition, we also review all previous reports of patients with anti-IFN-γ antibodies who were susceptible to NTM and Salmonella infections...
  6. doi Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis
    N Viget
    Service des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, France
    Gut 57:549-58. 2008
    Because of the increasing use of immunosuppressive and biological drugs, the occurrence of opportunistic infections has become a key safety issue for patients with inflammatory bowel disease (IBD)...
  7. ncbi The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting
    P Lewis White
    Department of Medical Microbiology, National Public Health Service, Cardiff, United Kingdom
    Clin Infect Dis 42:479-86. 2006
    ..Invasive aspergillosis (IA) is associated with high mortality. Successful outcome with treatment is linked to early diagnosis. The utility of classic diagnostic methods, however, is limited...
  8. ncbi Lessons learned about opportunistic infections in southeast Asia
    Veeranoot Nissapatorn
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 39:625-41. 2008
    ..Cryptococcosis (meningitis or disseminated) is one of the most common opportunistic infections in AIDS patients...
  9. ncbi [Collagen diseases with opportunistic infections]
    Katsuhiko Takabayashi
    Department of Medical Informatics and Management, Chiba University Hospital
    Nihon Rinsho Meneki Gakkai Kaishi 27:156-63. 2004
    Treatment of opportunistic infections emerging in collagen diseases is very important as well as the therapy of original diseases. Lung tuberculosis, Pneumocystis carinii and lung fungal infections are main opportunistic infections...
  10. pmc Single time point immune function assay (ImmuKnow) testing does not aid in the prediction of future opportunistic infections or acute rejection
    Janna Huskey
    Transplant Center, Department of Pediatrics, University of Colorado, Denver, CO, USA
    Clin J Am Soc Nephrol 6:423-9. 2011
    ..CD4+ T cell ATP release proposed as a means to quantify cell-mediated immunity in transplant recipients, could be considered as a potential tool to identify patients at risk for opportunistic infections (OI) or acute rejection (AR).
  11. ncbi Continuous infusion of escalated doses of amphotericin B deoxycholate: an open-label observational study
    Alexander Imhof
    Department of Internal Medicine, Medical Clinic B, University Hospital, Zurich, Switzerland
    Clin Infect Dis 36:943-51. 2003
    ..In conclusion, continuous infusion of AmB-d escalated to 2.0 mg/kg/day seems not to cause additional impairment of vital organ functions and to be well tolerated by most patients...
  12. doi Rhinocerebral mucormycosis in an adolescent with type 1 diabetes mellitus: case report
    R Ganesh
    Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai, India
    Ann Trop Paediatr 28:297-300. 2008
    ..A 14-year-old boy with rhino-orbito-cerebral mucormycosis and type 1 diabetes is described. He responded well to amphotericin B lipid complex followed by itraconazole...
  13. ncbi Bacteria forming a resident flora of the skin as a potential source of opportunistic infections
    Anna K Kaźmierczak
    Department of Pharmaceutical Microbiology, Medical University of Lodz, Pomorska 137, 90 235 Lódź, Poland
    Pol J Microbiol 53:249-55. 2004
    ..7% of them were the lipophilic species. These bacteria deserve special attention because among such species isolated from nosocomial infections, multiple antibiotic resistance of unknown origin was described...
  14. pmc Vitamin D status and incidence of pulmonary tuberculosis, opportunistic infections, and wasting among HIV-infected Tanzanian adults initiating antiretroviral therapy
    Christopher R Sudfeld
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 207:378-85. 2013
    ..We present the first prospective study of vitamin D among human immunodeficiency virus (HIV)-infected adults receiving antiretrovirals in sub-Saharan Africa...
  15. ncbi Prospective clinical evaluation of lower cut-offs for galactomannan detection in adult neutropenic cancer patients and haematological stem cell transplant recipients
    Johan Maertens
    Department of Haematology, University Hospital Gasthuisberg, Leuven, Belgium
    Br J Haematol 126:852-60. 2004
    ..However, the clinical benefit of lower cut-offs (particularly for earlier diagnosis) depends upon the kinetics of antigenaemia and the intensity of serum sampling...
  16. ncbi Detection of Pneumocystis carinii by DNA amplification in patients with connective tissue diseases: re-evaluation of clinical features of P. carinii pneumonia in rheumatic diseases
    K Saito
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka, Japan
    Rheumatology (Oxford) 43:479-85. 2004
    ..We evaluated the polymerase chain reaction (PCR) detection of Pneumocystis carinii DNA in induced sputum of patients with connective tissue diseases and assessed the clinical features of patients positive for P. carinii...
  17. doi Characteristics and stage of the underlying diseases could determine the risk of opportunistic infections in patients receiving alemtuzumab
    A Nosari
    Haematologica 93:e30-1. 2008
    Alemtuzumab is usually associated with opportunistic infections. We have treated 67 patients, 8 non-Hodgkin's lymphoma and 59 chronic lymphocytic leukemia (CLL) with campath...
  18. pmc Delayed opportunistic infections in hematopoietic stem cell transplantation patients: a surmountable challenge
    Kieren A Marr
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hematology Am Soc Hematol Educ Program 2012:265-70. 2012
    ..Late infections and methods to prevent them are reviewed herein...
  19. ncbi Opportunistic infections in renal allograft recipients
    R K Gupta
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Transplant Proc 39:731-3. 2007
    ..The overall incidence of opportunistic infections varies from center to center; up to 15% of renal transplant recipients die of these infections...
  20. ncbi Pneumocystis carinii pneumonia following a second infusion of infliximab
    T L Tai
    Rheumatology (Oxford) 41:951-2. 2002
  21. pmc CD4+ T cell-independent DNA vaccination against opportunistic infections
    Mingquan Zheng
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Clin Invest 115:3536-44. 2005
    ..The results of these studies show promise for CD4-independent vaccination against HIV-related or other opportunistic pathogens...
  22. ncbi Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Blood 101:2686-92. 2003
    ....
  23. ncbi Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003)
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, Laboratory Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Haematologica 91:986-9. 2006
    ..The complex and evolving epidemiology of IFI in severely immunocompromised patients is not well captured by current diagnostic methods...
  24. ncbi The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis
    J R Perfect
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 33:1824-33. 2001
    ..Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes...
  25. ncbi Management of infectious complications in the hematopoietic stem cell transplant recipient
    W Garrett Nichols
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Intensive Care Med 18:295-312. 2003
    ..New antivirals and antifungals have entered clinical practice and hold considerable promise for improved outcomes...
  26. ncbi Tumor necrosis factor inhibition and opportunistic infections
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, Cincinnati, Ohio, USA
    Clin Infect Dis 41:S187-8. 2005
  27. doi Risk factors for opportunistic infections in patients with inflammatory bowel disease
    Murat Toruner
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 134:929-36. 2008
    We sought to identify and quantify the clinical factors that were associated with opportunistic infections in inflammatory bowel disease patients.
  28. ncbi Viral infection in the renal transplant recipient
    Camille N Kotton
    Transplant Infectious Disease and Compromised Host Service, Infectious Disease Division, Massachusetts General Hospital, 55 Fruit Street GRJ 504, Boston, MA 02114, USA
    J Am Soc Nephrol 16:1758-74. 2005
    ..of invasive disease and "indirect effects," including immune suppression predisposing to other opportunistic infections and oncogenesis...
  29. ncbi Oral candidosis in patients with advanced cancer
    Andrew N Davies
    Department of Palliative Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, and Dental Institute, King s College London, United Kingdom
    Oral Oncol 42:698-702. 2006
    ..Candida albicans was the predominant organism isolated from the oral swabs of patients with oral candidosis. However, non-C. albicans species were the predominant organism in 25% cases, and a contributing organism in a further 19% cases...
  30. ncbi Serious infections after unrelated donor transplantation in 136 children: impact of stem cell source
    Juliet N Barker
    Division of Medical Hematology, Oncology, and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 11:362-70. 2005
    ..These data suggest that the risk of serious infection after pediatric UCB transplantation is comparable to that with unmanipulated BM...
  31. ncbi Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting
    Weerawat Manosuthi
    Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi 11000, Thailand
    J Infect 55:464-9. 2007
    To study incidence, risk factors, and impact of major opportunistic infections (OIs) after initiation of antiretroviral therapy (ART).
  32. doi CMV retinitis after intravitreal triamcinolone acetonide injection in a patient with Behçet's uveitis
    Ilknur Tugal-Tutkun
    Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul Tip Fakultesi, Goz Hastaliklari A D, Capa, 34390, Istanbul, Turkey
    Int Ophthalmol 30:591-3. 2010
    ..Local immunosuppression with IVTA may cause CMV retinitis. Awareness of this serious complication is important for correct diagnosis and treatment...
  33. ncbi Immunocompetent hosts as a reservoir of pneumocystis organisms: histological and rt-PCR data demonstrate active replication
    M Chabé
    Ecology of Parasitism, Lille Pasteur Institute, 1 rue du Prof Calmette BP245, 59019, Lille, France
    Eur J Clin Microbiol Infect Dis 23:89-97. 2004
    ..The results showed Pneumocystis organisms were able to replicate in the lungs of immunocompetent hosts, which indicates these hosts are a reservoir for Pneumocystis spp...
  34. doi European biologicals registers: methodology, selected results and perspectives
    A Zink
    German Rheumatism Research Centre, Epidemiology Unit, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 68:1240-6. 2009
    ....
  35. doi Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int Immunol 21:105-12. 2009
    ....
  36. ncbi Immunoparalysis as a cause for invasive aspergillosis?
    Koen J Hartemink
    Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Intensive Care Med 29:2068-71. 2003
    Aspergillus infections are among the most feared opportunistic infections in humans. These organisms are ubiquitous in nature; protection against infection is usually provided by anatomical barriers and by the immune system...
  37. ncbi Opportunistic infections in polymyositis and dermatomyositis
    Isabelle Marie
    Centre Hospitalier Universitaire de Rouen Boisguillaume and Inserm Unit 644, Rouen, France
    Arthritis Rheum 53:155-65. 2005
    To assess prevalence and characteristics of opportunistic infections in patients with polymyositis/dermatomyositis (PM/DM)...
  38. ncbi Hematogenous infections due to Candida parapsilosis: changing trends in fungemic patients at a comprehensive cancer center during the last four decades
    Amar Safdar
    Departments of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Diagn Microbiol Infect Dis 44:11-6. 2002
    ..parapsilosis infection. This study emphasizes the importance of periodic evaluation of candidemia, especially at centers caring for patients at risk...
  39. ncbi Infection and musculoskeletal conditions: Bacterial and opportunistic infections during anti-TNF therapy
    Anja Strangfeld
    German Rheumatism Research Centre, Epidemiology Unit, Chariteplatz 1, D 10117 Berlin, Germany
    Best Pract Res Clin Rheumatol 20:1181-95. 2006
    ..There are atypical signs and symptoms as well as atypical pathogen that should be considered. Patients should be educated about how to avoid infectious complications...
  40. ncbi Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis after anti-TNF-alpha therapy
    Raghu Krishnamurthy
    Veterans Affairs Southern Nevada Healthcare System, Division of Pulmonary and Critical Care Medicine, Las Vegas, Nevada, USA
    J Clin Rheumatol 13:150-2. 2007
    ..stercoralis infection. This is another, often latent, infection that should be considered in patients in or from endemic areas before institution of antitumor necrosis factor therapy...
  41. ncbi Rates and predictors of herpes zoster in patients with rheumatoid arthritis and non-inflammatory musculoskeletal disorders
    F Wolfe
    National Data Bank for Rheumatic Diseases, Arthritis Research Center Foundation, 1035 N Emporia, Suite 230 Wichita, KS 67214, USA
    Rheumatology (Oxford) 45:1370-5. 2006
    ..We examined its rate and predictors in rheumatoid arthritis (RA) and non-inflammatory musculoskeletal (MSK) disorders to determine if HZ was increased in RA and whether treatment contributed to the risk of HZ...
  42. ncbi Confirmation of administrative claims-identified opportunistic infections and other serious potential adverse events associated with tumor necrosis factor alpha antagonists and disease-modifying antirheumatic drugs
    J R Curtis
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Arthritis Rheum 57:343-6. 2007
  43. ncbi Epidemiology and clinical features of HIV infection/AIDS in Korea
    June Myung Kim
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 44:363-70. 2003
    ....
  44. pmc Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
    Joseph A Kovacs
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, NIH, Bethesda, Maryland, USA
    J Clin Invest 115:2139-48. 2005
    HIV infection leads to decreases in the number of CD4 T lymphocytes and an increased risk for opportunistic infections and neoplasms...
  45. doi Influence of tumour condition on the macrophage activity in Candida albicans infection
    J Venturini
    Experimental Immunopathology Laboratory, Department of Biological Sciences, College of Sciences, Sao Paulo State University UNESP, Bauru, Sao Paulo, Brazil
    Scand J Immunol 70:10-7. 2009
    ..activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host's susceptibility to opportunistic infections.
  46. ncbi Herpes simplex virus 1 pneumonia: conventional chest radiograph pattern
    U Umans
    Department of Radiology, Academic Hospital Vrije Universiteit, P O Box 7057, 1007MB Amsterdam, The Netherlands
    Eur Radiol 11:990-4. 2001
    ..The definite diagnosis of HSV pneumonia can be established only on the basis of culture of material obtained by broncho-alveolar lavage...
  47. ncbi Lymphocyte surge as a marker for immunorestitution disease due to Pneumocystis jiroveci pneumonia in HIV-negative immunosuppressed hosts
    V C C Cheng
    Division of Infectious Diseases, Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
    Eur J Clin Microbiol Infect Dis 23:512-4. 2004
  48. ncbi Management of opportunistic infections in solid-organ transplantation
    Loretta M Chiu
    University of Washington Medical Center, Seattle, Washington, USA
    Prog Transplant 14:114-29. 2004
    ..This review summarizes the pathophysiology, incidence, prevention, and treatment strategies of common posttransplant infections...
  49. ncbi Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy
    Samuel A Shelburne
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Medicine (Baltimore) 81:213-27. 2002
  50. doi Preventing and treating biologic-associated opportunistic infections
    Kevin L Winthrop
    Oregon Health and Science University, Portland, OR, USA
    Nat Rev Rheumatol 5:405-10. 2009
    ..latest developments in screening methodologies for latent tuberculosis infection, as well as potential preventive and therapeutic considerations for opportunistic infections associated with anti-TNF agents and other biologic therapies.
  51. ncbi Towards understanding Pseudomonas aeruginosa burn wound infections by profiling gene expression
    Piotr Bielecki
    Systems and Synthetic Biology Research Group, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany
    Biotechnol Lett 30:777-90. 2008
    ..The data sets obtained from global transcriptional profiling provide insights that will be essential for the development of new targets and options for prevention and intervention...
  52. ncbi Fumagillin treatment of intestinal microsporidiosis
    Jean Michel Molina
    Department of Infectious Diseases, Hôpital Saint Louis and University of Paris VII, Paris, France
    N Engl J Med 346:1963-9. 2002
    ..Intestinal microsporidiosis due to Enterocytozoon bieneusi is a cause of chronic diarrhea, malabsorption, and wasting in immunocompromised patients. Currently, there is no effective treatment...
  53. pmc Risk and predictors of infection leading to hospitalisation in a large primary-care-derived cohort of patients with inflammatory polyarthritis
    Jarrod Franklin
    Epidemiology Research Unit, Manchester University Medical School, Manchester M13 9PT, UK
    Ann Rheum Dis 66:308-12. 2007
    ..In particular, serious infection was associated with severe disease and use of corticosteroids. Robust estimates are required from prospective studies of incident cases...
  54. pmc Comparison of effects of amphotericin B deoxycholate infused over 4 or 24 hours: randomised controlled trial
    U Eriksson
    Medicine B, University Hospital, University of Zurich, CH 8091 Zurich, Switzerland
    BMJ 322:579-82. 2001
    ..To test the hypothesis that amphotericin B deoxycholate is less toxic when given by continuous infusion than by conventional rapid infusion...
  55. doi Identification of Bordetella spp. in respiratory specimens from individuals with cystic fibrosis
    T Spilker
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Microbiol Infect 14:504-6. 2008
    ..Consideration should be given to the presence of these organisms in the evaluation of CF sputum cultures...
  56. ncbi Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients
    C A Dykewicz
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of AIDS, STD, and TB Laboratory Research, Atlanta, GA 30333, USA
    Clin Infect Dis 33:139-44. 2001
    This article contains highlights of "Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients: Recommendations of the CDC, the Infectious Diseases Society of America, and the American Society ..
  57. ncbi Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibody
    Anton Y Peleg
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 44:204-12. 2007
    ..We assessed the risks of infection in, to our knowledge, the largest cohort and broadest range of organ transplant recipients yet reported to have received alemtuzumab...
  58. doi Opportunistic infections and other risks with newer multiple sclerosis therapies
    Joseph R Berger
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Ann Neurol 65:367-77. 2009
    ..Determining the actual risk frequency for many of these complications will likely require careful postmarketing surveillance...
  59. ncbi Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor
    Kevin L Winthrop
    Division of Infectious Diseases, Department of Medicine, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Nat Clin Pract Rheumatol 2:602-10. 2006
    ..These biologic agents have been associated with a variety of serious and 'routine' opportunistic infections; however, differences exist in the mechanisms of action of these agents that might confer variation in ..
  60. ncbi Detection of opportunistic infections by low-density microarrays: a diagnostic approach for granulomatous lymphadenitis
    Margarete Odenthal
    Institute for Pathology, University Clinic of Cologne, Cologne, Germany
    Diagn Mol Pathol 16:18-26. 2007
    ..Our results show that microarray technology combined with multiplex PCR is a promising and time-saving tool in molecular pathology of infectious diseases, allowing sensitive, simultaneous analyses of different pathogens...
  61. ncbi Molecular and phenotypic features for identification of the opportunistic pathogens Ochrobactrum spp
    Corinne Teyssier
    Laboratoire de Bacteriologie, Faculte de Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Med Microbiol 54:945-53. 2005
    ..anthropi and O. intermedium to the species level. However, definitive identification depends on genotyping methods...
  62. ncbi Infectious complications in SLE after immunosuppressive therapies
    Insoo Kang
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Rheumatol 15:528-34. 2003
    ..Careful monitoring of infectious complications is warranted in patients with systemic lupus erythematosus receiving immunosuppressive therapies, in particular those on high-dose glucocorticoids and cytotoxic drugs...
  63. ncbi Microsporidiosis: human diseases and diagnosis
    C Franzen
    Department of Internal Medicine I, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Microbes Infect 3:389-400. 2001
    ..A wide spectrum of diseases has been reported among persons infected with microsporidia and different diagnostic techniques have been developed during the last decade...
  64. ncbi The RATIO observatory: French registry of opportunistic infections, severe bacterial infections, and lymphomas complicating anti-TnFalpha therapy
    Florence Tubach
    INSERM U738, Bichat Teaching Hospital, Xavier Bichat School of Medicine, Paris 7 University, Paris, France
    Joint Bone Spine 72:456-60. 2005
    The RATIO observatory collects nationwide data on opportunistic infections, severe bacterial infections, and lymphomas in patients with a past or present history of tumor necrosis factor alpha (TNFalpha) antagonist treatment in France...
  65. ncbi Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis
    Marisa I Gomez
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Opin Pharmacol 7:244-51. 2007
    ..The capacity to grow in biofilms and the selection of mutants with a mucoid phenotype are major adaptations that allow its persistence in the airways...
  66. ncbi Combating opportunistic infections: coccidioidomycosis
    Neil M Ampel
    University of Arizona, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Expert Opin Pharmacother 5:255-61. 2004
    ..Intrathecal amphotericin B is required for those cases that fail. Prevention of coccidioidomycosis by environmental control is difficult. In the future, immunisation or immune modulation may offer protection...
  67. ncbi [Opportunistic infections and sarcoidosis]
    N Girard
    Service de Pneumologie Centre des Maladies Orphelines Pulmonaires, Hopital Louis Pradel, Lyon, France
    Rev Mal Respir 21:1083-90. 2004
    ..In spite of CD4+ T-lymphocytopenia and corticosteroids-induced immune suppression, the risk of opportunistic infection is not usually considered to be increased in sarcoidosis...
  68. ncbi A double-blind comparison of fluconazole and nystatin in the prevention of candidiasis in patients with leukaemia. Antifungal Prophylaxis Study Group
    G A Young
    Kanematsu Laboratories, University of Sydney, Royal Prince Alfred Hospital, Camperdown NSW, Australia
    Eur J Cancer 35:1208-13. 1999
    ..These results indicated fluconazole was more effective than nystatin in preventing Candida infections in patients with leukaemia; fluconazole was well tolerated...
  69. ncbi How to manage the infectious risk under anti-TNF in inflammatory bowel disease
    Emma L Culver
    Gastroenterology Unit, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Curr Drug Targets 11:198-218. 2010
    ..The risk of life-threatening opportunistic infections associated with anti-TNF therapy has obliged us to re-consider methods of prevention of infection and to ..
  70. doi Risk factors for opportunistic infections in infliximab-treated patients: the importance of screening in prevention
    C Garcia-Vidal
    Hospital Mutua de Terrassa, University of Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 28:331-7. 2009
    We sought to determine factors associated with opportunistic infections (OI) in infliximab-treated patients. A retrospective study cohort (1999-2004) was examined...
  71. ncbi Invasive fungal infection in systemic lupus erythematosus: an analysis of 15 cases and a literature review
    H S Chen
    Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kwei san Hsiang, Tao Yuan, Taiwan
    Rheumatology (Oxford) 46:539-44. 2007
    ..To analyse 15 cases of invasive fungal infection and mortality parameters in the largest series in the last 35 yrs of patients with systemic lupus erythematosus (SLE) at a single medical centre...
  72. ncbi Sarcoidosis and opportunistic infections
    R T Sadikot
    Medical Chest Unit, Castle Hill Hospital, North Humberside, United Kingdom
    South Med J 94:75-7. 2001
    ....
  73. doi Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Semin Fetal Neonatal Med 14:190-9. 2009
    ....
  74. doi Drug-specific risk of non-tuberculosis opportunistic infections in patients receiving anti-TNF therapy reported to the 3-year prospective French RATIO registry
    D Salmon-Ceron
    Service de Rhumatologie, Hopital Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre
    Ann Rheum Dis 70:616-23. 2011
    Anti-tumour necrosis factor (TNF) therapy may be associated with opportunistic infections (OIs).
  75. pmc A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs
    L Klareskog
    Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm 17176, Sweden
    Ann Rheum Dis 65:1578-84. 2006
    ..To evaluate the long-term safety and efficacy of etanercept in patients with rheumatoid arthritis...
  76. pmc Analysis of phylogenetic relationship of Cylindrocarpon lichenicola and Acremonium falciforme to the Fusarium solani species complex and a review of similarities in the spectrum of opportunistic infections caused by these fungi
    R C Summerbell
    Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands
    J Clin Microbiol 40:2866-75. 2002
    ..A novel synthesis of case reports shows that patients from areas with warm climates may develop a distinctive fusarial intertrigo caused by F. solani, Fusarium lichenicola, or Fusarium oxysporum...
  77. pmc Outcomes of kidney transplantation in HIV-infected recipients
    Peter G Stock
    University of California, San Francisco, San Francisco, CA 94143 0116, USA
    N Engl J Med 363:2004-14. 2010
    ..The outcomes of kidney transplantation and immunosuppression in people infected with human immunodeficiency virus (HIV) are incompletely understood...
  78. ncbi Renal allograft dysfunction associated with cytomegalovirus infection
    M J Shaver
    Division of Nephrology and Department of Pathology at the University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Am J Kidney Dis 34:942-6. 1999
    ..Further studies are needed to establish the mechanism of allograft dysfunction in the absence of inflammatory changes...
  79. doi [Non tuberculous anti-TNF associated opportunistic infections]
    I Marie
    Departement de Medecine Interne, CHU de Rouen, 1, rue de Germont, 76031 Rouen Cedex, France
    Rev Med Interne 31:353-60. 2010
    ..However, opportunistic infections have been increasingly reported in anti-TNFalpha-treated patients, and include non tuberculous ..
  80. ncbi Prevention and management of cytomegalovirus infection in solid-organ transplantation
    Kabeya Mwintshi
    Washington University School of Medicine, 660 S Euclid Avenue, Internal Medicine Renal Division, Campus Box 8126, St Louis, MO 63110, USA
    Expert Rev Anti Infect Ther 5:295-304. 2007
    ..Currently, the recommended treatment for CMV disease is intravenous ganciclovir...
  81. ncbi Opportunistic infections after blood and marrow transplantation
    J R Wingard
    Bone Marrow Transplant Program, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Transpl Infect Dis 1:3-20. 1999
    b>Opportunistic infections are major causes of morbidity and mortality following bone marrow transplantation...
  82. pmc Role of upper endoscopy in diagnosing opportunistic infections in human immunodeficiency virus-infected patients
    Ana Luiza Werneck-Silva
    Casa da AIDS Infectious Disease Division, School of Medicine, University of Sao Paulo, Rua Frei Caneca 255, CEP 05403 000, Sao Paulo, Brazil
    World J Gastroenterol 15:1050-6. 2009
    Highly active antiretroviral therapy (HAART) has dramatically decreased opportunistic infections (OIs) in human immunodeficiency virus (HIV)-infected patients...
  83. ncbi Opportunistic infections after renal transplantation
    Matthias P Hörl
    Department of Nephrology and Rheumatology, University of Dusseldorf, Dusseldorf, Germany
    Curr Opin Urol 12:115-23. 2002
    ..New diagnostic procedures and new treatment strategies should allow early detection and successful treatment of opportunistic infections in the majority of kidney transplant recipients.
  84. ncbi Prophylaxis of opportunistic infections in HIV-infected adults in sub-Saharan Africa: opportunities and obstacles
    Veronique Bortolotti
    AIDS 16:1309-17. 2002
  85. ncbi Preventing post-organ transplantation cytomegalovirus disease with ganciclovir: a meta-analysis comparing prophylactic and preemptive therapies
    Lorne N Small
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02446, USA
    Clin Infect Dis 43:869-80. 2006
    ..The goal of this meta-analysis was to compare the efficacy of universal prophylaxis and preemption using ganciclovir...
  86. ncbi Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients
    F Roblot
    Infectious Diseases Unit, Department of Internal Medicine, La Miletrie, University Hospital, 86021 Poitiers Cedex, France
    Eur J Clin Microbiol Infect Dis 21:523-31. 2002
    ..The diagnosis of PCP should be considered more frequently and advocated earlier in immunocompromised HIV-negative patients, since prompt diagnosis may improve the prognosis of these patients...
  87. pmc Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections
    Sabita Roy
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 6:442-65. 2011
    ..The role of opioid withdrawal in immunosuppression and the clinical relevance of these findings will also be discussed...
  88. ncbi Recurrent and opportunistic infections in children with primary intestinal lymphangiectasia
    Miranda P Dierselhuis
    Department of Pediatric Immunology and Rheumatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    J Pediatr Gastroenterol Nutr 44:382-5. 2007
  89. doi Kinetics of T-lymphocyte subsets and posttransplant opportunistic infections in heart and kidney transplant recipients
    Sandra A Calarota
    Virology and Microbiology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Transplantation 93:112-9. 2012
    ..We analyzed the kinetics of T-lymphocyte subsets within the first 8 months posttransplant and their correlation with opportunistic infections (OIs) in solid organ transplant recipients.
  90. pmc Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients
    Evert Jan Wils
    Erasmus MC Daniel den Hoed Cancer Center, Department of Hematology, EA Rotterdam, The Netherlands
    Haematologica 96:1846-54. 2011
    ..However, it is still unclear to what extent insufficient recovery of thymopoiesis predicts for subsequent opportunistic infections and non-relapse mortality.
  91. doi Asymptomatic carriage of Pneumocystis jiroveci in elderly patients with rheumatoid arthritis in Japan: a possible association between colonization and development of Pneumocystis jiroveci pneumonia during low-dose MTX therapy
    Shunsuke Mori
    Clinical Research Center for Rheumatic Disease and Department of Rheumatology, Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto, Japan
    Mod Rheumatol 18:240-6. 2008
    ..One of the recent concerns arising from this therapy is a possible increase in the rate of opportunistic infections, particularly Pneumocystis jiroveci pneumonia (PCP)...
  92. ncbi Host-microbe interactions: fungi invasive human fungal opportunistic infections
    Jean Paul Latge
    Curr Opin Microbiol 5:355-8. 2002
    ....
  93. doi Pneumocystis jirovecii colonization in patients treated with infliximab
    Gustavo Wissmann
    Pneumocystis Study Group, Infectology Unit, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Eur J Clin Invest 41:343-8. 2011
    ..host defence, and the suppression of its biological activity may be associated with the increased risk of opportunistic infections. The frequent use of infliximab in clinical practice has identified Pneumocystis jirovecii pneumonia (PcP)..
  94. ncbi Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy
    M C Genovese
    Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road 203, Palo Alto, CA 94304, USA
    Ann Rheum Dis 67:547-54. 2008
    ..To evaluate the safety and efficacy of abatacept during 2 years of the ATTAIN (Abatacept Trial in Treatment of Anti-TNF INadequate responders) trial in patients with rheumatoid arthritis...
  95. doi A problem-oriented approach to liver disease in oncology patients
    G B McDonald
    Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, WA 98109 1024, USA
    Gut 57:987-1003. 2008
  96. doi Opportunistic infections with anti-tumor necrosis factor-α therapy in inflammatory bowel disease: meta-analysis of randomized controlled trials
    Alexander C Ford
    Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK
    Am J Gastroenterol 108:1268-76. 2013
    ..These drugs carry the theoretical risk of opportunistic infection, but no systematic review and meta-analysis has examined this issue specifically...
  97. doi Endemic and opportunistic infections in Brazilian solid organ transplant recipients
    M V Batista
    Infections in Immunocompromised Host Group, Hospital das Clinicas da Faculdade de Medicina, University of Sao Paulo, Sao Paulo, Brazil
    Trop Med Int Health 16:1134-42. 2011
    To evaluate the frequency and clinical features of endemic and other opportunistic infections in liver or kidney transplant recipients in four transplant centres in different geographical areas of Brazil.
  98. doi Klebsiella oxytoca: opportunistic infections in laboratory rodents
    Andre Bleich
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Lab Anim 42:369-75. 2008
    ..In conclusion, K. oxytoca is an opportunistic pathogen capable of inducing pathological lesions in different rodent species...
  99. doi The "Black Turbinate" sign: An early MR imaging finding of nasal mucormycosis
    S Safder
    Department of Radiology, West Virginia University Hospital, Morgantown, USA
    AJNR Am J Neuroradiol 31:771-4. 2010
    ..Early diagnosis and treatment are essential for survival and minimizing neurologic sequelae. CT and MR imaging are often used in the diagnostic work-up; however, CT findings are nonspecific...
  100. ncbi Rhinocerebral zygomycosis in childhood acute lymphoblastic leukaemia
    M Ryan
    Department of Haematology and Oncology, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Eur J Pediatr 160:235-8. 2001
    ....
  101. ncbi Opportunistic infections of mice and rats: Jacoby and Lindsey revisited
    Anthony J Carty
    University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA 19104, USA
    ILAR J 49:272-6. 2008
    ..It is therefore critical to make appropriate decisions about identifying outbreaks in a timely fashion and controlling the spread of infection once identified. Such efforts should be practical, reproducible, and cost-effective...

Research Grants76

  1. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..PDC in the circulation, along with depletion of CD4 T-lymphocytes is associated with the development of opportunistic infections, including viral infections...
  2. MECHANISM-BASED DRUG SELECTION AND DESIGN: NUCLEOTIDE SA
    Buddy Ullman; Fiscal Year: 2003
    ..R01 application was submitted in response to PA AI-98-100, "National Cooperative Drug Discovery Groups-Opportunistic Infections" (NCDDG-OI) by a group of investigators from the Oregon Health Sciences University, the University of ..
  3. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..Hence, most SCID infants are not recognized until diagnosed with life-threatening opportunistic infections, resulting in substantial morbidities and reduced overall survival of 50-70% Thus, the ability to detect ..
  4. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..infections such as HIV or Measles are associated with immunosuppression and enhanced susceptibility to opportunistic infections, resulting in millions of death worldwide...
  5. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In AIDS patients'susceptibility to opportunistic infections, such as Pneumocystis Pneumonia (PCP), occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid ..
  6. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
    ..clinical trials further evaluating primary antiretroviral therapeutic agents, other therapies targeted at opportunistic infections, and interventions to prevent perinatal HIV transmission...
  7. Charles J Smith; Fiscal Year: 2014
    ..applicant): Disruption of the defense barriers between the host and its indigenous microflora can lead to opportunistic infections which have a serious impact on human health...
  8. International Workshop on Opportunistic Protists (IWOP-12, 13 and 14)
    Louis M Weiss; Fiscal Year: 2012
    ..Workshops on Opportunistic Protists (IWOP) is a series of meetings devoted to infections (termed opportunistic infections) that cause serious problems in AIDS patients and other individuals with defective immune systems...
  9. A Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
    Courtney C Aldrich; Fiscal Year: 2012
    ..Additionally, M. tuberculosis and other atypical mycobacteria are now classified as opportunistic infections of AIDS patients...
  10. JOHN JAMES LETTERIO; Fiscal Year: 2016
    ..Standard therapy for GVHD is often therapeutically sub-optimal and predisposes to opportunistic infections and relapse of the underlying disease...
  11. Mechanisms and regulation of serine resolvases
    Phoebe A Rice; Fiscal Year: 2012
    ..maintenance of many drug resistance-carrying plasmids found in Staphylococcus aureus, a common cause of opportunistic infections. Closely related recombination systems found in other bacteria also aid in the maintenance and/or ..
  12. Molecular Basis of Bacterial Quorum Sensing Gene Regulation
    MAIR E CHURCHILL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Opportunistic infections by Pseudomonas aeruginosa are a major cause of death in cystic fibrosis patients and immune-compromised individuals...
  13. Jakub Tolar; Fiscal Year: 2016
    ..of the body surface area, mutilating scarring, joint contractures, and strictures of the esophagus, with opportunistic infections and aggressive squamous cell carcinoma as principal causes of early death...
  14. Generation and Evaluation of KSHV VLPs as Vaccines
    GARY S contact HAYWARD; Fiscal Year: 2010
    ..Kaposi's sarcoma (KS) was one of the original defining opportunistic infections in the AIDS epidemic, when these highly angiogenic skin lesions first appeared in an aggressive often ..
  15. Longitudinal Studies of HIV-Associated Bacterial Pneumonia
    William N Rom; Fiscal Year: 2013
    ..load below the limits of detection in most patients, increases CD4+ counts, and reduces the incidence of opportunistic infections. Pulmonary infectious complications are still recognized: bacterial pneumonia, tuberculosis, CMV and PCP...
  16. Brendan Cormack; Fiscal Year: 2014
    ..We have identified two key transcriptional regulators that dramatically alter virulence and are studying how they control the infectious process. ..
  17. Michael D Carrithers; Fiscal Year: 2016
    ..Patients with AIDS remain susceptible to opportunistic infections and, along with homeless veterans, are at great risk for the development of TB...
  18. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2012
    Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  19. Aleem Gangjee; Fiscal Year: 2016
    ..provided by applicant): Despite the availability of highly active antiretroviral therapy (HAART or ART), opportunistic infections (OIs) remain the leading cause of considerable morbidity and mortality in HIV infected persons as stated ..
  20. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    ..jirovecii (pj) is the causative agent of Pneumocystis pneumonia(PcP), one of the most frequent and severe opportunistic infections in immunocompromised patients...
  21. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..Soll evaluates factors of pathogenicity in the yeast, Candida albicans, the frequent underlying reason of opportunistic infections in immunosuppressed patients...
  22. Delayed Tolerance Induction in Living Related Donor Renal Transplant Recipients
    Suzanne T Ildstad; Fiscal Year: 2012
    ..These agents have significant toxicities, including nephrotoxicity, opportunistic infections, increased rate of malignancy, diabetes, and hypertension...
  23. Ramiro Mendonca Murata; Fiscal Year: 2014
    ..immunodeficiency syndrome (AIDS) is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies...
  24. Benzophenones: Novel natural agents which inhibits HIV and Candida
    Ramiro Mendonca Murata; Fiscal Year: 2011
    ..immunodeficiency syndrome (AIDS) is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies...
  25. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    ..M. tuberculosis and other atypical mycobacteria are now classified as opportunistic infections of AIDS patients...
  26. Tammie E Quest; Fiscal Year: 2016
    ..antiretroviral therap (ART), higher proportion with virologic suppression, higher CD4 gain, fewer opportunistic infections (OI), fewer hospitalizations, lower depression scores, and better symptom management (including cognitive ..
  27. JONATHAN DAVID KATZ; Fiscal Year: 2014
    ..This approach has three major drawbacks: (i) it lacks specificity;(ii) it increases the risks of opportunistic infections and cancers;and (iii) it causes secondary organ damage and toxicity...
  28. Dennis E Kyle; Fiscal Year: 2014
    ..encepahalitis (GAE), a chronic disease seen most often in immunocompromised hosts and those at risk of opportunistic infections. Acanthamoeba spp. also causes amoebic keratitis, skin, nasopharyngeal, and disseminated infections...
  29. Fayyaz S Sutterwala; Fiscal Year: 2014
    ..C. albicans can also cause severe opportunistic infections particularly in immunocompromised patients ranging from mucocutaneous candidiasis to bloodstream ..
  30. The immunopathogenesis of HIV-related Immune Reconstitution Inflammatory Syndrome
    DAVID BISAGAYA MEYA; Fiscal Year: 2013
    ..with ART leads to the development of exaggerated antigen-specific inflammatory responses directed against opportunistic infections (OIs), resulting in clinical deterioration...
  31. University of California, Berkeley (UCB)/University of *
    Arthur L Reingold; Fiscal Year: 2006
    ..diagnostic methods related to AIDS/HIV;clinical microbiology related to STDs, TB, malaria, and other opportunistic infections;and the ethical issues involved in human research in general, and AIDS-related research in developing ..
  32. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  33. Cholesterol Uptake by Cryptosporidium
    Isabelle Coppens; Fiscal Year: 2010
    ..provided by applicant): Cryptosporidiosis is universally recognized as one of the most serious opportunistic infections that complicates AIDS...
  34. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2009
    ..albicans, and we believe that our proposed studies, jointly focused on subtelomeres and transcriptional regulation will shed new light on virulence strategies in C. glabrata. ..
  35. Molecular Mechanism of Severe Congenital Neutropenia
    H Grimes; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Severe Congenital Neutropenia (SCN) predisposes affected humans to opportunistic infections because of a profound deficiency in the production of neutrophils...
  36. Sangwei Lu; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  37. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles Smith; Fiscal Year: 2009
    Project Summary Disruption of the defense barriers between the host and its indigenous microflora leads to opportunistic infections which can have a serious impact on human health...
  38. PAMELA RANEL HALL; Fiscal Year: 2015
    ..Typically, S. aureus causes opportunistic infections in those at the extremes of age and with serious medical conditions...
  39. PETER JOHN ESPENSHADE; Fiscal Year: 2014
    ..However, immunocompromised individuals risk acquiring opportunistic infections originating from this commensal population of microflora...
  40. 2011 Antimicrobial Peptides Gordon Research Conference
    Nita H Salzman; Fiscal Year: 2011
    ..of the pathophysiology of human diseases, including inflammatory bowel disease, sexually transmitted and opportunistic infections, atopic dermatitis, and others...
  41. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol L Miller-Graziano; Fiscal Year: 2012
    ..mortality results from hypo-responsiveness of both the innate and adaptive immune responses resulting in opportunistic infections &multiple organ failure (MOF)...
  42. Christopher J Hoffmann; Fiscal Year: 2014
    ..In industrialized countries, HAART has lead to a shift in causes of death from acute opportunistic infections to chronic diseases...
  43. Judith G Berman; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: Fungal infections cause serious opportunistic infections in immunocompromised patients, such as those infected with the Human Immunodeficiency Virus and with ..
  44. Protection of vaccine immunity by inhibiting Fas/FasL signaling
    Maria S Salvato; Fiscal Year: 2010
    ..High levels of CD4+FasL+ cells during AIDS also reduce immunity against opportunistic infections and neoplastic events...
  45. HIV induces Gli Proteins to skew naive CD4+ T cells to Th1 and TGF-b effectors
    Christel H Uittenbogaart; Fiscal Year: 2010
    ..during chronic HIV infection disables the immune system's control over viral replication as well as opportunistic infections. The viral proteins HIV gp120 and Tat have been attributed to this immunosuppression, but the underlying ..
  46. 2013 Antimicrobial Peptides GRC/GRS
    Gill Diamond; Fiscal Year: 2013
    ..of the pathophysiology of human diseases, including inflammatory bowel disease, sexually transmitted and opportunistic infections, atopic dermatitis, and others...
  47. Raymond T Chung; Fiscal Year: 2016
    ..S., particularly among injection drug users (IDU). With the success of HAART, traditional opportunistic infections among HIV-infected persons have been replaced by end stage liver disease due to viral hepatitis, ..
  48. Rituximab for Treatment of Type 1 Diabetes: Impact on JC Viral Proliferation
    MARK DAVID PESCOVITZ; Fiscal Year: 2010
    ..of subjects compared with placebo treated subjects (less than 3% in either group), and there were no opportunistic infections. However, the small sample size (46 rituximab-treated subjects) limits the ability to generalize this ..
  49. Increasing Animal Foods in Diets of HIV-Infected Kenyan Women and Their Children
    Judith A Ernst; Fiscal Year: 2011
    ..of iron and zinc, results in improved clinical outcomes, B weight gain, lean body mass, resistance to opportunistic infections, growth and development in children and ability to carry out normal tasks of daily living in women...
  50. James A Lederer; Fiscal Year: 2016
    ..If an event does occur, an immediate concern for survivors will be the development of opportunistic infections because radiation and injury damage the immune system making it difficult for patients to resist ..
  51. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
    ..reactions interfere with the effective use of SMX, which is the drug of choice for the prevention of opportunistic infections in immunocompromised patients...
  52. JENNIFER LYNN JOHNS; Fiscal Year: 2015
    ..phagocytophilum infection, including opportunistic infections, but the mechanisms involved in altered PMN trafficking during A...
  53. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2011
    ..phagocytophilum infection, including opportunistic infections, but the mechanisms involved in altered PMN trafficking during A...
  54. Jan R Mead; Fiscal Year: 2014
    ..Susceptibility to opportunistic infections may persist despite increased CD4 levels, due to dysregulated cytokines or effector CD4 functions...
  55. Haiti AIDS Research Training: Models to Implementation
    Jean William Pape; Fiscal Year: 2013
    ..Ministry of Health has asked GHESKIO (Haitian Study Group for the Study of Kaposi's Sarcoma and Opportunistic Infections) to lead this network through training, supervision, monitoring and evaluation, and through the conduct ..
  56. WILLIAM JOSEPH MURPHY; Fiscal Year: 2015
    ..disease (GVHD) and a profound period of immune deficiency leaving the patient highly susceptible to opportunistic infections. Natural killer (NK) cells represent critical components of the innate immune response and are being ..
  57. David L Williams; Fiscal Year: 2016
    ..resulting in disseminated tissue injury as well as a prolong immune suppression that can predispose to opportunistic infections. The presence of myocardial dysfunction in patients with sepsis/septic shock/MODS is well known...
  58. David R Boulware; Fiscal Year: 2014
    ..provided by applicant): Cryptococcal meningitis (CM) is a leading cause of death among all AIDS-related opportunistic infections, causing an estimated 1 million infections and 625,000 deaths worldwide annually...
  59. Immune Modulation/Hematopoietic Cell Transplantation
    ROBERT JON SOIFFER; Fiscal Year: 2010
    ..In contrast, deficient reconstitution of immune responsiveness leads to opportunistic infections with a variety of microbial and viral pathogens...
  60. MYST opportunities for Toxoplasma drug development
    William J Sullivan Jr; Fiscal Year: 2010
    ..to the NIAID watch list of Category B pathogens of interest for Biodefense, but have long been serious opportunistic infections in AIDS and other immunosuppressed patients...
  61. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael D Roth; Fiscal Year: 2010
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies.
  62. Patricia Fitzgerald-Bocarsly; Fiscal Year: 2014
    ..deficient in HIV-infected individuals, and this dysfunction is strongly correlated with progression to opportunistic infections. In addition to evidence for important protective roles of the pDC in HIV infection, an overzealous pDC ..
  63. Nicotine & Immunopathogenesis of Cryptococcal meningitis
    Mohan Sopori; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Opportunistic infections of the central nervous system are common complication in acquired immunodeficiency syndrome (AIDS) patients...
  64. LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONS
    Andre Rosowsky; Fiscal Year: 2004
    ..Analogs of PT653 with a COOH, NH2, or OH group on the tricyclic moiety, and prodrugs thereof, will be made with the goal of improving aqueous solubility without sacrificing potency or selectivity. ..
  65. Antigenic variation by multiple promoter inversions in Mycoplasma penetrans
    Michael Calcutt; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Human mycoplasmas cause chronic and opportunistic infections and may also contribute to the pathogenesis of other microbial agents. Indeed, epidemiological studies reveal that M...
  66. ANTIVIRAL ACTIVITY OF THE IMMUNOSUPPRESSANT LEFLUNOMIDE
    W Waldman; Fiscal Year: 2004
    ..pharmacologic immunosuppression puts transplant recipients at risk for development of opportunistic infections. Of these, cytomegalovirus (CMV) remains one of the most common sources of serious complications, ..
  67. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
    ..Cotrimoxazole (Trimethoprim-sulfamethoxazole, TMP-SMX) is the agent of choice for prophylaxis against opportunistic infections associated with HIV/AIDS and other immuno-compromised states...
  68. PROTEINS OF CANDIDA ALBICANS AN AIDS-RELATED PATHOGEN
    Paula Sundstrom; Fiscal Year: 1993
    Candidosis is one of the most important AIDS- related opportunistic infections, afflicting the majority of AIDS victims...
  69. Development of immune assays for HPV-32
    Michael Hagensee; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Opportunistic infections of the oral cavity afflict 50% of all HIV infected patients, and include oropharyngeal candidiasis (OPC), oral hairy leukoplakia (OHL) and oral warts caused by the mucosatropic ..
  70. HIV-1 Clade Diversity and Macrophage Mediated Neurotoxicity in HIV-1 Dementia
    Jialin Zheng; Fiscal Year: 2009
    ..pathogenesis or simply an artifact of confounding variables such as data sampling, clinical diagnosis or opportunistic infections is unclear...
  71. CLINICAL GENE THERAPY PROGRAM FOR THE TREATMENT OF AIDS
    Rafael Amado; Fiscal Year: 2002
    ..The advent of highly active antiretroviral therapy has been associated with a decline in the incidence of opportunistic infections and prolonged survival...
  72. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2003
    Mortality in AIDS patients is due to overwhelming opportunistic infections caused by bacteria, fungi, protozoa, and viruses...