hepatitis c

Summary

Summary: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

Top Publications

  1. ncbi Global epidemiology of hepatitis C virus infection
    Colin W Shepard
    Epidemiology Branch, Division of Viral Hepatitis, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Lancet Infect Dis 5:558-67. 2005
  2. pmc Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
  3. ncbi Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence
    Khayriyyah Mohd Hanafiah
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Hepatology 57:1333-42. 2013
  4. pmc Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    Takaji Wakita
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Nat Med 11:791-6. 2005
  5. pmc Response-guided telaprevir combination treatment for hepatitis C virus infection
    Kenneth E Sherman
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0595, USA
    N Engl J Med 365:1014-24. 2011
  6. ncbi The global burden of hepatitis C
    Daniel Lavanchy
    World Health Organization, Geneve, Switzerland
    Liver Int 29:74-81. 2009
  7. pmc Epidemiology of hepatitis C virus infection
    Miriam J Alter
    University of Texas Medical Branch, Galveston, Texas 77555, USA
    World J Gastroenterol 13:2436-41. 2007
  8. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
  9. pmc A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:164-71. 2013
  10. ncbi Binding of hepatitis C virus to CD81
    P Pileri
    IRIS, Chiron, Siena 53100, Italy
    Science 282:938-41. 1998

Detail Information

Publications331 found, 100 shown here

  1. ncbi Global epidemiology of hepatitis C virus infection
    Colin W Shepard
    Epidemiology Branch, Division of Viral Hepatitis, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Lancet Infect Dis 5:558-67. 2005
    b>Hepatitis C virus (HCV) is a major cause of liver disease worldwide and a potential cause of substantial morbidity and mortality in the future...
  2. pmc Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
    b>Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide...
  3. ncbi Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence
    Khayriyyah Mohd Hanafiah
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Hepatology 57:1333-42. 2013
    ..This study was conducted to collect and analyze available prevalence data to be used for estimating the hepatitis C virus (HCV) burden of disease...
  4. pmc Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    Takaji Wakita
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Nat Med 11:791-6. 2005
    b>Hepatitis C virus (HCV) infection causes chronic liver diseases and is a global public health problem. Detailed analyses of HCV have been hampered by the lack of viral culture systems...
  5. pmc Response-guided telaprevir combination treatment for hepatitis C virus infection
    Kenneth E Sherman
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0595, USA
    N Engl J Med 365:1014-24. 2011
    Patients with chronic infection with hepatitis C virus (HCV) genotype 1 often need 48 weeks of peginterferon-ribavirin treatment for a sustained virologic response. We designed a noninferiority trial (noninferiority margin, -10...
  6. ncbi The global burden of hepatitis C
    Daniel Lavanchy
    World Health Organization, Geneve, Switzerland
    Liver Int 29:74-81. 2009
    b>Hepatitis C is of concern both to industrialized and developing countries. Preliminary unpublished estimates of the global burden of disease (GBD) attributable to HCV-related chronic liver disease seem to be substantial...
  7. pmc Epidemiology of hepatitis C virus infection
    Miriam J Alter
    University of Texas Medical Branch, Galveston, Texas 77555, USA
    World J Gastroenterol 13:2436-41. 2007
    Globally, hepatitis C virus (HCV) has infected an estimated 130 million people, most of whom are chronically infected...
  8. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
    ..The attributable fraction at the specific sites varies from 100% of cervix cancers attributable to the papilloma viruses to a tiny proportion (0.4%) of liver cancers (worldwide) caused by liver flukes...
  9. pmc A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:164-71. 2013
    Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer. We performed RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA to mimic HCV infection...
  10. ncbi Binding of hepatitis C virus to CD81
    P Pileri
    IRIS, Chiron, Siena 53100, Italy
    Science 282:938-41. 1998
    Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population and is a major cause of liver disease. HCV infection is also associated with cryoglobulinemia, a B lymphocyte proliferative disorder...
  11. pmc Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews
    Paul K Nelson
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia
    Lancet 378:571-83. 2011
    ..We estimated national, regional, and global prevalence and population size for hepatitis C virus (HCV) and hepatitis B virus (HBV) in injecting drug users (IDUs).
  12. ncbi Evolving epidemiology of hepatitis C virus
    D Lavanchy
    Interlifescience, Massagno Ticino, Switzerland
    Clin Microbiol Infect 17:107-15. 2011
    More than 20 years after the discovery of the hepatitis C virus (HCV), it is now well established that HCV is of global importance affecting all countries, leading to a major global health problem that requires widespread active ..
  13. ncbi Replication of hepatitis C virus
    Darius Moradpour
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH 1011 Lausanne, Switzerland
    Nat Rev Microbiol 5:453-63. 2007
    Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide...
  14. pmc Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication
    Ines Romero-Brey
    Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany
    PLoS Pathog 8:e1003056. 2012
    ..In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming a ..
  15. ncbi The prevalence of hepatitis C virus infection in the United States, 1999 through 2002
    Gregory L Armstrong
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 144:705-14. 2006
    Defining the primary characteristics of persons infected with hepatitis C virus (HCV) enables physicians to more easily identify persons who are most likely to benefit from testing for the disease.
  16. ncbi Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders
    Kazuaki Chayama
    Hiroshima University, Hiroshima, Japan
    Hepatology 55:742-8. 2012
    Patients with chronic hepatitis C virus (HCV) infection and previous null response to pegylated interferon (Peg-IFN) and ribavirin (RBV) have limited therapeutic options...
  17. ncbi The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence
    Katy M E Turner
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Addiction 106:1978-88. 2011
    To investigate whether opiate substitution therapy (OST) and needle and syringe programmes (NSP) can reduce hepatitis C virus (HCV) transmission among injecting drug users (IDUs).
  18. ncbi Immunology of hepatitis B virus and hepatitis C virus infection
    Barbara Rehermann
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
    Nat Rev Immunol 5:215-29. 2005
    More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma...
  19. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
    ..b>Hepatitis C virus (HCV) infection is associated with the highest HCC incidence in persons with cirrhosis, occurring twice ..
  20. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection...
  21. ncbi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
    ..interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotype 1 (HCV-1) infection...
  22. ncbi Epidemiology of hepatitis C virus infection in Pakistan
    Nadeem Sajjad Raja
    Department of Medical Microbiology, Southend University Hospital NHS Foundation Trust, Essex, United Kingdom
    J Microbiol Immunol Infect 41:4-8. 2008
    Since the discovery of hepatitis C virus (HCV) in 1989 as the causative agent of post-transfusion non-A non-B hepatitis, the epidemiology, pattern of transmission, different genotypes and clinical consequences of the disease have been ..
  23. pmc EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
    Joachim Lupberger
    Institut National de la Sante et de la Recherche Medicale, U748, Strasbourg, France
    Nat Med 17:589-95. 2011
    b>Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited and there are no prevention strategies...
  24. ncbi Resistance to direct antiviral agents in patients with hepatitis C virus infection
    Christoph Sarrazin
    J W Goethe University Hospital, Medizinische Klinik 1, Frankfurt am Main, Germany
    Gastroenterology 138:447-62. 2010
    Chronic hepatitis C virus (HCV) infection is one of the major causes of cirrhosis, hepatocellular carcinoma, and liver failure that leads to transplantation...
  25. pmc A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection
    John A Mengshol
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 5:e9504. 2010
    Approximately 200 million people throughout the world are infected with hepatitis C virus (HCV)...
  26. ncbi A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt
    William Sievert
    Monash Medical Centre and Monash University, Melbourne, Vic, Australia
    Liver Int 31:61-80. 2011
    The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions.
  27. ncbi Adaptive immune responses in acute and chronic hepatitis C virus infection
    David G Bowen
    Center for Vaccines and Immunity, Columbus Children s Research Institute, Columbus, Ohio OH 43205, USA
    Nature 436:946-52. 2005
    The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally...
  28. ncbi Bayesian coalescent inference of past population dynamics from molecular sequences
    A J Drummond
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 22:1185-92. 2005
    ..we compare the Bayesian skyline plot model to previous coalescent approaches by analyzing two real data sets (hepatitis C virus in Egypt and mitochondrial DNA of Beringian bison) that have been previously investigated using ..
  29. ncbi Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    Min Gao
    Department of Virology, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    Nature 465:96-100. 2010
    The worldwide prevalence of chronic hepatitis C virus (HCV) infection is estimated to be approaching 200 million people...
  30. ncbi Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies
    J M Micallef
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Darlinghurst, Sydney, NSW, Australia
    J Viral Hepat 13:34-41. 2006
    A large number of studies have reported on spontaneous viral clearance rates in acute hepatitis C infection, however most have been small, and reported rates have varied quite widely...
  31. ncbi Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
    Judith M Gottwein
    Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
    Hepatology 49:364-77. 2009
    Six major hepatitis C virus (HCV) genotypes and numerous subtypes have been described, and recently a seventh major genotype was discovered...
  32. ncbi The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt
    C Frank
    University of Maryland, School of Medicine, Department of Epidemiology and Preventive Medicine, Baltimore, USA
    Lancet 355:887-91. 2000
    The population of Egypt has a heavy burden of liver disease, mostly due to chronic infection with hepatitis C virus (HCV). Overall prevalence of antibody to HCV in the general population is around 15-20%...
  33. ncbi Course and outcome of hepatitis C
    Jay H Hoofnagle
    Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 36:S21-9. 2002
    The hepatitis C virus (HCV) is a small enveloped RNA virus belonging to the family flaviviridae and genus hepacivirus...
  34. ncbi Eradication of hepatitis C virus infection and the development of hepatocellular carcinoma: a meta-analysis of observational studies
    Rebecca L Morgan
    Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 37, Atlanta, GA 30333, USA
    Ann Intern Med 158:329-37. 2013
    b>Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma (HCC). In the United States, this form of cancer occurs in approximately 15 000 persons annually...
  35. pmc Birth-death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV)
    Tanja Stadler
    Department of Environmental Systems Science, Eidgenossische Technische Hochschule Zurich, 8092 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:228-33. 2013
    ..We apply this method to data from the United Kingdom HIV-1 epidemic and Egyptian hepatitis C virus (HCV) epidemic...
  36. pmc Hepatitis C virus entry depends on clathrin-mediated endocytosis
    Emmanuelle Blanchard
    Equipe Hepatite C, CNRS UMR8161, Institut de Biologie de Lille, 1 rue du Professeur Calmette, BP447, 59021 Lille Cedex, France
    J Virol 80:6964-72. 2006
    Due to difficulties in cell culture propagation, the mechanisms of hepatitis C virus (HCV) entry are poorly understood...
  37. pmc A genetically humanized mouse model for hepatitis C virus infection
    Marcus Dorner
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 474:208-11. 2011
    b>Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model...
  38. pmc Robust hepatitis C virus infection in vitro
    Jin Zhong
    Departments of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:9294-9. 2005
    The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines...
  39. pmc Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
    Bruno Sainz
    Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA
    Nat Med 18:281-5. 2012
    b>Hepatitis C virus (HCV) is a leading cause of liver disease worldwide...
  40. ncbi Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    Simone Susser
    JW Goethe University Hospital, Frankfurt, Germany
    Hepatology 50:1709-18. 2009
    Boceprevir is a hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor that is currently being evaluated in combination with peginterferon alfa-2b and ribavirin in phase 3 studies...
  41. ncbi MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
    Heike Varnholt
    Institute for Pathology, University Hospital Cologne, Cologne, Germany
    Hepatology 47:1223-32. 2008
    ..All patients were infected with hepatitis C, and most had liver cirrhosis...
  42. pmc Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
    Lucy Golden-Mason
    Department of Medicine, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, USA
    J Virol 83:9122-30. 2009
    ..characterize the expression of T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) in chronic hepatitis C infection...
  43. ncbi Assembly of infectious hepatitis C virus particles
    Ralf Bartenschlager
    Department of Infectious Diseases, Molecular Virology, Im Neuenheimer Feld 345, Heidelberg University, D 69120 Heidelberg, Germany
    Trends Microbiol 19:95-103. 2011
    A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles...
  44. pmc Hepatitis C virus infection protein network
    B de Chassey
    IMAP Team, Inserm Unit 851, Lyon, France
    Mol Syst Biol 4:230. 2008
    A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection...
  45. ncbi Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    Shunsuke Ura
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 49:1098-112. 2009
    ..from 12 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and 14 patients with hepatitis C virus (HCV)-related HCC, including background liver tissues and normal liver tissues obtained from nine ..
  46. ncbi Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    Christoph Sarrazin
    Klinik fur Innere Medizin II, Universitat des Saarlandes, Homburg Saar, Germany
    Gastroenterology 132:1767-77. 2007
    Telaprevir (VX-950), a hepatitis C virus (HCV) NS3.4A protease inhibitor, has shown strong antiviral activity in phase 1 clinical studies...
  47. ncbi New insights into HCV replication: potential antiviral targets
    Charles M Rice
    Rockefeller University, New York, NY, USA
    Top Antivir Med 19:117-20. 2011
    The ultimate goal of hepatitis C virus (HCV) treatment is the eradication of the virus. Ongoing research continues to add to knowledge of the HCV life cycle, revealing new potential viral and host targets for the development of therapy...
  48. pmc Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
    Troels K H Scheel
    Laboratory of Virology and Infectious Disease, Center for Study of Hepatitis C, The Rockefeller University, New York, New York, USA
    Nat Med 19:837-49. 2013
    More than two decades of intense research has provided a detailed understanding of hepatitis C virus (HCV), which chronically infects 2% of the world's population...
  49. ncbi Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
    Judith M Gottwein
    Copenhagen Hepatitis C Program CO HEP, Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre and Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Gastroenterology 141:1067-79. 2011
    The hepatitis C virus (HCV) genotype influences efficacy of interferon (IFN)-based therapy. HCV protease inhibitors are being licensed for treatment of genotype 1 infection...
  50. ncbi Humanistic and economic impacts of hepatitis C infection in the United States
    Marco daCosta Dibonaventura
    Health Sciences Practice, Kantar Health, New York, NY 10010, USA
    J Med Econ 13:709-18. 2010
    Prior research examining the effect of hepatitis C virus (HCV) on health-related quality of life (HRQoL) and healthcare costs is flawed because non-patient controls were not adequately comparable to HCV patients...
  51. pmc Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection
    Rowena A Bull
    School of Medical Sciences, University of New South Wales, Australia
    PLoS Pathog 7:e1002243. 2011
    b>Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease...
  52. ncbi Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes
    Isabel Fofana
    INSERM, U748, Strasbourg, France
    Gastroenterology 139:953-64, 964.e1-4. 2010
    b>Hepatitis C virus (HCV) infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape...
  53. pmc Determinants of viral clearance and persistence during acute hepatitis C virus infection
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 194:1395-406. 2001
    The virological and immunological features of hepatitis C virus (HCV) infection were studied weekly for 6 months after accidental needlestick exposure in five health care workers, four of whom developed acute hepatitis that progressed to ..
  54. ncbi Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression
    Gary L Davis
    Division of Hepatology, Baylor University Medical Center and Baylor Regional Transplant Institute, Dallas, Texas, USA
    Gastroenterology 138:513-21, 521.e1-6. 2010
    The prevalence of chronic hepatitis C (CH-C) remains high and the complications of infection are common. Our goal was to project the future prevalence of CH-C and its complications.
  55. pmc Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation
    Yun Sook Lim
    National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
    J Biol Chem 286:11290-8. 2011
    b>Hepatitis C Virus (HCV) nonstructural 5A (NS5A) is a pleiotropic protein involved in viral RNA replication and modulation of the cellular physiology in HCV-infected cells...
  56. pmc Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses
    George Koutsoudakis
    Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg 69120, Germany
    J Virol 80:5308-20. 2006
    The lack of an efficient system to produce hepatitis C virus (HCV) particles has impeded the analysis of the HCV life cycle...
  57. pmc Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    Denise Egger
    Institute for Medical Microbiology, University of Basel, CH 4003 Basel, Switzerland
    J Virol 76:5974-84. 2002
    ..In the present study, the capacity of hepatitis C virus (HCV) proteins to elicit intracellular membrane alterations was investigated by expressing, in ..
  58. pmc Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
    Barbara Rehermann
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH DHHS, Bethesda, MD 20892, USA
    J Clin Invest 119:1745-54. 2009
    Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been made in our understanding of its life cycle and interaction with the host immune system...
  59. pmc Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection
    Cheryl L Day
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 76:12584-95. 2002
    Vigorous virus-specific CD4+ T-helper-cell responses are associated with successful control of hepatitis C virus (HCV) and other human viral infections, but the breadth and specificity of responses associated with viral containment have ..
  60. ncbi FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest
    Anais Vallet-Pichard
    Universite Paris Descartes, Paris, France
    Hepatology 46:32-6. 2007
    To optimize the management of patients with chronic hepatitis C virus (HCV) infection, noninvasive tests to determine the degree of hepatic fibrosis have been developed...
  61. ncbi Awareness of infection, knowledge of hepatitis C, and medical follow-up among individuals testing positive for hepatitis C: National Health and Nutrition Examination Survey 2001-2008
    Maxine M Denniston
    Epidemiology and Surveillance Branch, Division of Viral Hepatitis, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Hepatology 55:1652-61. 2012
    Many persons infected with hepatitis C virus (HCV) are unknown to the healthcare system because they may be asymptomatic for years, have not been tested for HCV infection, and only seek medical care when they develop liver-related ..
  62. pmc IFITM1 is a tight junction protein that inhibits hepatitis C virus entry
    Courtney Wilkins
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Hepatology 57:461-9. 2013
    ..IFN) continues to be the foundation for the current standard of care combination therapy for chronic hepatitis C virus (HCV) infection, yet the component interferon-stimulated genes (ISGs) that mediate the antiviral actions ..
  63. pmc Meta-analysis of hepatitis C seroconversion in relation to shared syringes and drug preparation equipment
    Enrique R Pouget
    National Development and Research Institutes, Inc, New York, NY 10010, USA
    Addiction 107:1057-65. 2012
    We conducted a systematic review of studies reporting seroincidence of hepatitis C infection (HCV) in relation to shared syringes and drug preparation equipment among injection drug users (IDUs)...
  64. pmc Modeling hepatitis C virus infection using human induced pluripotent stem cells
    Robert E Schwartz
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:2544-8. 2012
    ..Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral ..
  65. ncbi Factors that predict response of patients with hepatitis C virus infection to boceprevir
    Fred Poordad
    Cedars Sinai Medical Center, Los Angeles, California, USA
    Gastroenterology 143:608-18.e1-5. 2012
    Little is known about factors associated with a sustained virologic response (SVR) among patients with hepatitis C virus (HCV) infection to treatment with protease inhibitors.
  66. pmc Metabolomic profile of hepatitis C virus-infected hepatocytes
    Barbara Roe
    Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    PLoS ONE 6:e23641. 2011
    b>Hepatitis C virus (HCV) is capable of disrupting different facets of lipid metabolism and lipids have been shown to play a crucial role in the viral life cycle...
  67. pmc Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting
    Benjamin Maasoumy
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e55285. 2013
    ..The aim of our study was to analyze the eligibility and safety of P/R/PI treatment in a real world setting of a tertiary referral center...
  68. ncbi Hepatitis C virus production requires apolipoprotein A-I and affects its association with nascent low-density lipoproteins
    Carmine Mancone
    National Institute for Infectious Diseases L Spallanzani IRCCS, Rome, Italy
    Gut 60:378-86. 2011
    The life cycle of hepatitis C virus (HCV) is intimately linked to the lipid metabolism of the host...
  69. ncbi (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry
    Noémie Calland
    Institut Pasteur de Lille, Center for Infection and Immunity of Lille CIIL, Lille, France
    Hepatology 55:720-9. 2012
    Here, we identify (-)-epigallocatechin-3-gallate (EGCG) as a new inhibitor of hepatitis C virus (HCV) entry. EGCG is a flavonoid present in green tea extract belonging to the subclass of catechins, which has many properties...
  70. pmc Completion of the entire hepatitis C virus life cycle in genetically humanized mice
    Marcus Dorner
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 501:237-41. 2013
    More than 130 million people worldwide chronically infected with hepatitis C virus (HCV) are at risk of developing severe liver disease...
  71. pmc Hepatitis C virus host cell entry
    Alexander Ploss
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Diseases, The Rockefeller University, New York, NY 10065, USA
    Curr Opin Virol 2:14-9. 2012
    The hepatitis C virus (HCV) is a major medical problem with at least 130 million infected individuals worldwide...
  72. pmc Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitis C virus E2 protein confer noninterfering, additive neutralization
    Alexander W Tarr
    School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    J Virol 86:2739-49. 2012
    Chronic hepatitis C virus (HCV) infection can persist even in the presence of a broadly neutralizing antibody response...
  73. ncbi A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel
    Markus Cornberg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Int 31:30-60. 2011
    ..of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel.
  74. pmc Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
    Erick Giang
    Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:6205-10. 2012
    b>Hepatitis C virus (HCV) infects ∼2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt, the country with the highest HCV prevalence...
  75. pmc Frequency distribution of hepatitis C virus genotypes in different geographical regions of Pakistan and their possible routes of transmission
    Muhammad Idrees
    Division of Molecular Virology and Molecular Diagnostics, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore 53700, Pakistan
    BMC Infect Dis 8:69. 2008
    Information regarding hepatitis C virus genotypes and subtypes circulating in Pakistan and various risk factors for their transmission are not known well...
  76. ncbi An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    Alessandra Mangia
    Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Gastroenterology 139:821-7, 827.e1. 2010
    ..IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV...
  77. pmc Scaling up the national methadone maintenance treatment program in China: achievements and challenges
    Wenyuan Yin
    Chinese Center for Disease Control and Prevention, Beijing, China
    Int J Epidemiol 39:ii29-37. 2010
    ..Clinic services have been extended to offer clients a range of ancillary services, including HIV, syphilis and hepatitis C testing, information, education and communication, psychosocial support services and referrals for treatment of ..
  78. pmc Role of N-linked glycans in the functions of hepatitis C virus envelope proteins incorporated into infectious virions
    François Helle
    Institut Pasteur de Lille, Bâtiment IBL, 59021 Lille Cedex, France
    J Virol 84:11905-15. 2010
    b>Hepatitis C virus (HCV) envelope glycoproteins are highly glycosylated, with generally 4 and 11 N-linked glycans on E1 and E2, respectively...
  79. pmc Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers
    Xinxia Peng
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA
    BMC Genomics 10:373. 2009
    b>Hepatitis C virus (HCV) is a major cause of chronic liver disease by infecting over 170 million people worldwide...
  80. ncbi Hepatitis C virus infection in USA: an estimate of true prevalence
    Eric Chak
    Department of Medicine, University of California, Sylmar, CA, USA
    Liver Int 31:1090-101. 2011
    ..only the civilian, non-institutionalized population of USA and may have underestimated the prevalence of hepatitis C virus (HCV) in this country...
  81. ncbi Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Gastroenterology 127:1513-24. 2004
    Recent evidence suggests that toll-like receptors (TLRs) recognize certain viruses. We reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) proteins activate inflammatory pathways in monocytes...
  82. pmc Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease
    Yi Zhou
    Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
    Antimicrob Agents Chemother 52:110-20. 2008
    In patients chronically infected with hepatitis C virus (HCV) strains of genotype 1, rapid and dramatic antiviral activity has been observed with telaprevir (VX-950), a highly selective and potent inhibitor of the HCV NS3-4A serine ..
  83. ncbi Modelling viral and immune system dynamics
    Alan S Perelson
    Theoretical Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Nat Rev Immunol 2:28-36. 2002
    ..in our understanding of human immunodeficiency virus 1 and other viruses, such as hepatitis B virus and hepatitis C virus, that cause chronic infection...
  84. pmc Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro
    Po Yuan Ke
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Clin Invest 121:37-56. 2011
    ..b>Hepatitis C virus (HCV) is a single-stranded, positive-sense, membrane-enveloped RNA virus that can cause chronic liver ..
  85. pmc IL28B and the control of hepatitis C virus infection
    Ashwin Balagopal
    Division of Infectious Diseases, Center for Viral Hepatitis, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 139:1865-76. 2010
    Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors...
  86. pmc Viral hepatitis in HIV infection
    Margaret James Koziel
    Division of Infectious Disease, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 356:1445-54. 2007
  87. pmc Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
    Alexander Ploss
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 457:882-6. 2009
    b>Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The development of much needed specific antiviral therapies and an effective vaccine has been hampered by the lack of a convenient small animal model...
  88. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
    Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease inhibitors in <1% of the viral quasispecies may still allow >1000-fold viral load reductions upon treatment, consistent with their reported ..
  89. pmc Hepatitis C virus hijacks host lipid metabolism
    Gulam H Syed
    Department of Medicine, Moores Cancer Center, University of California, San Diego, CA 92093, USA
    Trends Endocrinol Metab 21:33-40. 2010
    b>Hepatitis C virus (HCV) enhances its replication by modulating host cell lipid metabolism. HCV circulates in the blood in association with lipoproteins...
  90. ncbi Epidemiology of hepatitis B and C viruses: a global overview
    Helen S Te
    Liver Transplantation, Center for Liver Diseases, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 7120, Chicago, IL 60637, USA
    Clin Liver Dis 14:1-21, vii. 2010
    ..the prevalence, disease burden, genotype distribution, and transmission patterns of hepatitis B virus (HBV) and hepatitis C virus in the 6 World Health Organization regions...
  91. ncbi Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy
    Norio Akuta
    Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
    Intervirology 48:372-80. 2005
    Patients with high titer (>/=100 kIU/ml) of hepatitis C virus (HCV) genotype 1b do not achieve highly sustained virological response rates to combination therapy with interferon plus ribavirin...
  92. ncbi Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-claudin-1 associations
    Sophie E Krieger
    Institut National de la Sante et de la Recherche Medicale, U748, Strasbourg, France
    Hepatology 51:1144-57. 2010
    The tight junction protein claudin-1 (CLDN1) has been shown to be essential for hepatitis C virus (HCV) entry-the first step of viral infection...
  93. ncbi Global estimates of prevalence of HCV infection among injecting drug users
    Carmen Aceijas
    Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, University of London, London, UK
    Int J Drug Policy 18:352-8. 2007
    ..In this paper, we review evidence of HCV prevalence among injecting drug users (IDUs) worldwide...
  94. ncbi Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
    Some epidemiologic studies suggest a link between hepatitis C virus (HCV) infection and some B-cell non-Hodgkin's lymphomas...
  95. pmc Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
    Xianfang Wu
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 8:e1002617. 2012
    ..hepatocytes isolated from patient biopsies represent the most physiologically relevant cell culture model for hepatitis C virus (HCV) infection, but these primary cells are not readily accessible, display individual variability, and ..
  96. pmc Neutralizing antibody response to hepatitis C virus
    Yong Wang
    Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Viruses 3:2127-45. 2011
    A critical first step in a "rational vaccine design" approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection...
  97. ncbi The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry
    Sandra Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 54:1947-55. 2011
    b>Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Current antiviral therapy fails to clear infection in a substantial proportion of cases...
  98. ncbi Hepatitis C virus entry: beyond receptors
    Luke W Meredith
    Institute for Biomedical Research, University of Birmingham, Birmingham, UK
    Rev Med Virol 22:182-93. 2012
    ..In this review, we summarise the recent literature on HCV entry mechanisms with a view to realising the future potential of therapeutically targeting this process...
  99. pmc Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation
    Joyce A Wilson
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada
    J Virol 85:2342-50. 2011
    MicroRNA 122 (miR-122) increases the accumulation and translation of hepatitis C virus (HCV) RNA in infected cells through direct interactions with homologous sequences in the 5' untranslated region (UTR) of the HCV genome...
  100. pmc Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus
    Susanne Knapp
    Department of Hepatology, Division of Medicine, Imperial College London, UK
    Hepatology 51:1168-75. 2010
    ..antigen (HLA)-C ligand has been shown to be associated with spontaneous resolution of viremia following hepatitis C virus (HCV) infection...
  101. ncbi Hepatocellular carcinoma and hepatitis C in the United States
    Hashem B El-Serag
    Sections of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, 77030, USA
    Hepatology 36:S74-83. 2002
    Chronic infection with hepatitis C virus (HCV) is a major risk factor for development of hepatocellular carcinoma (HCC)...

Research Grants86

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Transfused patients are also screened annually for hepatitis C surface antibody and if positive, PCR for hepatitis C is measured...
  2. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Due to the epidemic of hepatitis C in the 1960's-70's, incidence has increased;approximately 3...
  3. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..11] In addition to chronic HBV, other chronic liver disease etiologies including chronic hepatitis C, non- alcoholic fatty liver disease and autoimmune hepatitis have been shown to cause substantial morbidity and ..
  4. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic Hepatitis C virus (HCV) infection remains a global health concern with nearly 200 million carriers worldwide...
  5. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    ..RNA and the recently reported crystal structures of YFV and DEN2 RNA helicases and those of hepatitis C virus and bovine viral diarrhea virus (BVDV) RdRP for docking studies...
  6. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..C5A corresponds to a small (18 amino acids) N-terminal region (aa 3-20) of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) (477 amino acids)...
  7. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..An estimated 170 million people worldwide and 4 million people in the United States are infected with hepatitis C virus (HCV)...
  8. Mechanisms of Neutralizing Antibody Resistance in Chronic HCV and HIV Infection
    JUSTIN RICHARD BAILEY; Fiscal Year: 2013
    ..by applicant): The research objectives of this K08 career development award are to to define shared patterns of hepatitis C virus (HCV) envelope mutation that mediate escape from autologous neutralizing antibody (nAb), to measure the ..
  9. Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)
    PATRICK O'CONNOR; Fiscal Year: 2013
    ..and prescription drug abuse and addiction, tobacco, alcohol, HIV, and medical complexities such as pain and hepatitis C;(2) Synergy with well established, high quality post-doctoral training programs at Yale;(3) The use of clinical ..
  10. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..Her research has focused on the interaction between lipid metabolism and chronic liver disease, specifically hepatitis C and non-alcoholic fatty liver disease (NAFLD)...
  11. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..effective vaccines for many of the world's serious chronic infectious diseases, including HIV, malaria and hepatitis C, have not been successful;vaccines that look promising in other species often fail in human clinical trials...
  12. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection has a worldwide prevalence of 3% and is the main entity responsible for liver transplantation in developed countries for treatment of cirrhosis...
  13. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    ..S. The leading cause of cirrhosis is the hepatitis C virus infection which affects more than 4 million Americans...
  14. Structure and Function of the Hepatitis C Virus Genome
    Peter Sarnow; Fiscal Year: 2013
    ..carcinoma, a leading cause of cancer-related deaths, is caused by infection with either hepatitis B or hepatitis C virus (HCV)...
  15. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is an expected increased incidence of chronic hepatitis C virus infection (HCV) in the Unites States within the next years, with subsequent increased risks of liver damage, including fibrosis ..
  16. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..Knowledge thus gained will help us to advance towards our long-term objective to develop RNA interference based therapies to treat HIV infection and counteract the deleterious effects of opioid-abuse. ..
  17. Hepatocyte Nox proteins in the pathogenesis of hepatocellular carcinoma
    Jinah Choi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis C virus is a major etiologic agent of hepatocellular carcinoma (HCC). HCV-induced HCC is typically preceded by chronic hepatitis and cirrhosis...
  18. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..from complications of liver fibrosis/cirrhosis are expected to triple over the next decade as a result of the hepatitis C epidemic and the growing incidence of liver disease associated with non-alcoholic steatohepatitis...
  19. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) is a major public health problem with more than 170 millions people are currently infected. Most infections become chronic often leading to liver cirrhosis and cancer...
  20. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..non-tumor tissues, and test whether the miRNA methylation levels are different for hepatitis B virus (HBV) and hepatitis C virus (HCV)-related HCC;(2) To examine whether a subgroup of miRNA genes showing significant methylation ..
  21. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    b>Hepatitis C virus (HCV) infects 170 million people worldwide and exacts a heavy toll on global health. Diseases caused by chronic HCV infection include acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma...
  22. Role of inflammation and cellular stress in the pathogenesis of type 2 diabetes
    Liangyou Rui; Fiscal Year: 2013
    ..B2 levels were increased in the livers of mice with obesity and humans with alcoholic fatty liver disease or hepatitis C. Obesity was associated with an increase in Cdc37 (an Hsp90 cochaperone) that bound to NIK...
  23. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..Chronic liver disease due to drug toxicity, alcoholic steatohepatitis (ASH), non-alcoholic hepatitis (NASH), hepatitis C and B are over-represented in the veteran population...
  24. MECHANISMS OF LIVER INJURY BY HEPATITIS C AND ALCOHOL
    Steven A Weinman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The combination of Hepatitis C virus (HCV) infection and alcohol consumption produces a more severe liver disease than either condition alone with increased rates of both cirrhosis and hepatocellular ..
  25. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2013
    ..with disruption of crime, social disruption, and severe health consequences including the spread of HIV and hepatitis C. There are several medications already available or the treatment of heroin addiction, including methadone, ..
  26. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..by applicant): The major goal of this proposal is to understand the molecular mechanism(s) of liver fibrosis by hepatitis C virus (HCV) infection. Hepatitis C virus (HCV) is the leading cause of chronic liver disease worldwide...
  27. Liver cancer risk and prevention among persons living with HIV/AIDS
    LESLEY SUEJEAN PARK; Fiscal Year: 2013
    ..The aging of this population, impaired immune function, and high prevalence of liver cancer risk factors hepatitis C virus, hepatitis B virus, an alcohol abuse and dependency contribute to the rising incidence of liver cancer ..
  28. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2012
    ..health care expenditures, and intravenous drug abuse contributes substantially to the spread of HIV/AIDS, hepatitis C and other infections...
  29. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..risk of disease transmission from current blood supplies including HIV, Hepatitis A virus, B19 parvovirus, Hepatitis C virus, and infectious prion proteins the agents associated with variant Creutzfeldt-Jakob disease, mad cow ..
  30. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a causal agent of chronic liver disease in humans, afflicting more than 123 million people worldwide (approximately 2% of the human population)...
  31. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..Susceptibility factors include hepatitis C, alcohol use, smoking, iron overload, HIV, estrogens and an inherited partial deficiency of UROD...
  32. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..an expert in HCV-induced chronic liver diseases will supervise the epidemiological and clinical components of hepatitis C virus (HCV) and liver cirrhosis. I propose two developmental projects that will further my career progress...
  33. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2013
    ..area will help medical professionals better understand the causes of liver disease and lead to the discovery of new treatments for patients suffering from liver diseases associated with diabetes, obesity, hepatitis C, and alcoholism.
  34. Antisense Mediated Treatment of Hepatitis B Virus Infection
    STEFAN FRANK WIELAND; Fiscal Year: 2013
    ..together with our collaborators at the Salk Institute, we have recently demonstrated efficient HBV and hepatitis C virus infection in a novel chimeric mouse model repopulated with human hepatocytes that allows us to study all ..
  35. Murine Model of HCV-Associated Human Liver Cancer
    Lishan Su; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic hepatitis C virus (HCV) infection is now the leading cause of hepatocellular carcinoma (HCC), a highly lethal cancer with rapidly increasing incidence in the U.S...
  36. 2011 Nucleic Acids Gordon Research Conference
    Christopher D Lima; Fiscal Year: 2011
    ..Acids GRC, specifically RNAi therapeutics, are currently in clinical trials for macular degeneration and hepatitis C. PUBLIC HEALTH RELEVANCE: The stated goal of NIGMS is to support research that "is the foundation for disease ..
  37. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..We therefore will target RNA viruses, focusing on pathogens with abnormally high global burdens of disease: hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (..
  38. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..immunodeficiency virus (HIV-1 and HIV-2), simian immunodeficiency virus (SIV), dengue virus, Marburg virus, hepatitis C, Ebola, and cytomegalovirus...
  39. Catalytic inactivation of miRNA function by customized RNase P-based ribozymes
    DANIEL R contact SCHOENBERG; Fiscal Year: 2010
    ..acid metabolism, the abundant liver-specific microRNA miR-122 also plays a central role in the pathogenesis of Hepatitis C virus (HCV) and associated hepatocellular carcinoma by stimulating viral replication through its binding to ..
  40. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The genomes of a number of viruses, including poliovirus, hepatitis C virus and foot-and-mouth disease virus contain structured RNA elements known as `internal ribosomal entry sites&..
  41. HCV Strain Variation and HCC
    Andrea D Branch; Fiscal Year: 2012
    ..core gene sequences of "cases" who developed HCC to those of "controls" who did not develop HCC during the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial...
  42. Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic Steatosis
    Phyllis C Tien; Fiscal Year: 2013
    ..b>Hepatitis C virus (HCV) coinfection is implicated in many of these cases, but other causes of liver injury are common in ..
  43. Hepatitis C: Studies of Immunity and Pathogenesis
    Charles Rice; Fiscal Year: 2009
    b>Hepatitis C virus (HCV) is an important cause of chronic liver disease, cirrhosis and cancer. Its limited host range (humans and chimpanzees) and poor replication in cell culture have made it difficult to study...
  44. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..e. hepatitis C virus), but also in other T cell-mediated pathological conditions such as autoimmunity, graft rejection or ..
  45. Listeria-Based Therapeutic Cancer Vaccine for Melanoma
    Dirk G Brockstedt; Fiscal Year: 2011
    ..were dosed safely with up to 1 x 109 live-attenuated bacteria for the treatment of advanced cancers and chronic hepatitis C infections...
  46. Murine coronavirus neurovirulence: role of type I interferon response
    Susan R Weiss; Fiscal Year: 2013
    ..Moreover, understanding type I IFN signaling in the CNS may aid in developing or refining therapeutic applications for type I IFNs, which are currently used in treatment of MS and hepatitis C.
  47. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis C and hepatitis B virus infections in humans are characterized by hepatocellular necrosis, inflammation, and development of hepatoma...
  48. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2011
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV)...
  49. Intracellular immunization strategy in inhibit HCV related liver cancer
    Srikanta Dash; Fiscal Year: 2010
    ..strategy with a genetically engineered human antibody clone as a novel antiviral therapy against the hepatitis C virus...
  50. Key determinants of dengue virus neutralization by naturally occurring human mAbs
    Scott A Smith; Fiscal Year: 2013
    ..to develop my career in a direction independently of my mentor and begin to work on the rational design of a hepatitis C virus vaccine. My surroundings at Vanderbilt are ideal for my proposed project and my career development...
  51. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..coli, HIV and Hepatitis C infected drug users, and patients with inflammatory bowel disease) can only be done using the GS FLX system...
  52. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    Chronic hepatitis C (HCV) infection is a major cause of liver disease, cirrhosis, and hepatocellular carcinoma (HCC) in alcoholics...
  53. The mechanism of mRNA recruitment to the human ribosome.
    Christopher S Fraser; Fiscal Year: 2013
    ..The mechanism by which the hepatitis c virus (HCV) internal ribosome entry site (IRES) functionally replaces the cap-binding complex in mRNA ..
  54. GB Virus C and Non-Hodgkins Lymphoma Risk and Prognosis
    Jack T Stapleton; Fiscal Year: 2013
    ..In addition, hepatitis C virus is an accepted risk for NHL, and GBV-C is closely related to HCV, sharing considerable amino acid ..
  55. Role of Pellino1 in liver inflammation
    Liselotte E Jensen; Fiscal Year: 2010
    ..It is estimated that over 2 billion people worldwide are infected with hepatitis B virus (HBV) or hepatitis C virus (HCV)...
  56. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..We demonstrated that circulating EMP levels, initially elevated in patients with Hepatitis C cirrhosis, were decreased to the levels seen in healthy people two weeks after liver transplantation...
  57. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus, hepatitis C virus, hepatitis A virus, respiratory syncytial virus, and human immunodeficiency virus and play a critical ..
  58. The effects of hepatitis C virus (HCV) E2 protein on host immunomodulation
    Jack T Stapleton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) is an important and worldwide cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma...
  59. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Hepatitis C virus (HCV) is a leading cause of liver disease including cancer...
  60. Transgenic mouse models of HCV infection and replication
    Jieyun Jiang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). HCV chronically infects approximately 4 million people in the U.S...
  61. Genetic Determinants of Drug Effects
    Tamara J Phillips; Fiscal Year: 2012
    ..programs that address the complicating effects of substance abuse on other chronic health problems such as hepatitis C, HIV/AIDS, cancers, and heart disease...
  62. Glycerolipid synthesis in liver
    ROSALIND ANNE COLEMAN; Fiscal Year: 2013
    ..hepatocellular carcinoma, and the presence of TAG droplets in liver is required for replication of viruses like hepatitis C. Our long term goal is to determine how the enzymes in the pathway of TAG synthesis contribute to hepatic fatty ..
  63. A Novel Method of Generating Hepatitis C Virus-Like Particles using Lentivirus
    Boro Dropulic; Fiscal Year: 2009
    ..retroviral diseases such as AIDS but also for a wide range of other viral diseases of clinical interest such as hepatitis C, yellow fever, West Nile fever, dengue fever, and influenza...
  64. Structure and Function of the Hepatitis C Virus Genome
    PETER contact SARNOW; Fiscal Year: 2010
    ..carcinoma, a leading cause of cancer-related deaths, is caused by infection with either hepatitis B or hepatitis C virus (HCV)...
  65. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2005
    ..goal is to use pharmacogenetic principles to better understand the influence of liver disease associated with hepatitis C on drug disposition and develop new tools to evaluate hepatic function...
  66. HEPATITIS C VIRUS IN ETIOLOGY OF WA RHEUMATOID FACTORS
    Vincent Agnello; Fiscal Year: 2001
    We have established the association of hepatitis C virus (HCV) infection with type II cryoglobulinemia (MC-II) and with the WA crossidiotype (XId) positive monoclonal rheumatoid factors (WA mRF), and the selective concentration of HCV ..
  67. PROTEOMICS AND HEPATITIS C: FIBROSIS AND PROGNOSIS
    Glenn Gourley; Fiscal Year: 2005
    Liver fibrosis is an important factor in the progression of disease for millions of people with chronic hepatitis C. There is a fundamental gap in understanding the development of liver fibrosis in people with chronic hepatitis C which ..
  68. VIRAHEP-C Clinical Center
    Anna Lok; Fiscal Year: 2005
    Chronic hepatitis C is the leading cause of chronic liver disease and cirrhosis in the United States and is now the leading cause for liver transplantation due to end-stage liver disease. Approximately 1...
  69. EXPERIMENTAL MODELS AND CLINICAL VIROLOGY OF HEPATITIS C
    Nelson Fausto; Fiscal Year: 1999
    ..HCV infection is characterized by persistent viremia and often progressive liver disease. Chronic hepatitis C is the most common indication for liver transplantation in adults, and at the University of Washington Medical ..
  70. Interferon-gamma To Treat Chronic HCV Infection
    Andrew Muir; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Current treatment options for chronic hepatitis C infection remain limited and unsatisfactory...
  71. Cell Culture System for Hepatitis C Virus Genotype 1a
    Adrian Di Bisceglie; Fiscal Year: 2009
    b>Hepatitis C virus (HCV) results in persistent infection in up to 80% of infected individuals and causes a wide spectrum of liver diseases...
  72. Hepatitis C Clinical Trial-Clinical Center
    Jules L Dienstag; Fiscal Year: 2009
    Patients with chronic hepatitis C who do not respond to antiviral treatment are at risk of progression to cirrhosis, liver failure, hepatocellular carcinoma (HCC) and death...
  73. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2005
    An estimated 600,000 African-Americans have chronic hepatitis C virus (HCV) infection, representing 22% of the total infected population in the U.S...
  74. HEPATITIS C IN CLINICALLY DISCORDANT HEMOPHILIC SIBLINGS
    Michael Fried; Fiscal Year: 2002
    The clinical spectrum of hepatitis C is variable and the factors responsible for these divergent outcomes with chronic hepatitis C infection remain unknown...
  75. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..b>Hepatitis C is the major risk factor for HCC with approximately 3 million individuals currently infected nationwide...
  76. DECREASING SEVERITY OF RECURRENT HEPATITIS C IN LIVER
    Lakshmi Gaur; Fiscal Year: 1999
    Based on observations we have recently made, there is evidence that the recurrence of hepatitis C virus (HCV)-induced liver disease in transplanted livers may be reduced by the careful selection of the donor...
  77. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2002
    ..virological techniques, Non-A Non-B hepatitis patients have now been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "..
  78. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
    ..virological techniques, Non-A Non-B hepatitis patients have now been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "..
  79. STUDIES OF THE NATURAL HISTORY OF HEPATITIS C IN LIVER
    Robert Carithers; Fiscal Year: 2002
    Chronic hepatitis C virus infection has emerged as the most important form of viral hepatitis in the United States...