hepatitis b

Summary

Summary: INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.

Top Publications

  1. ncbi Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
    D Lavanchy
    World Health Organization, Communicable Disease Surveillance and Response, Geneva, Switzerland
    J Viral Hepat 11:97-107. 2004
  2. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
  3. ncbi Association between nucleoside analogues and risk of hepatitis B virus–related hepatocellular carcinoma recurrence following liver resection
    Chun Ying Wu
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    JAMA 308:1906-14. 2012
  4. ncbi Hepatitis B virus infection--natural history and clinical consequences
    Don Ganem
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, USA
    N Engl J Med 350:1118-29. 2004
  5. pmc Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews
    Paul K Nelson
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia
    Lancet 378:571-83. 2011
  6. ncbi Immunology of hepatitis B virus and hepatitis C virus infection
    Barbara Rehermann
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
    Nat Rev Immunol 5:215-29. 2005
  7. ncbi Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma
    Jian Huang
    Human Genome Center of Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 44:1117-21. 2012
  8. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
  9. ncbi Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination
    Xiaofeng Liang
    Chinese Center for Disease Control and Prevention, Beijing, China
    Vaccine 27:6550-7. 2009
  10. pmc Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma
    De Ke Jiang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Nat Genet 45:72-5. 2013

Detail Information

Publications293 found, 100 shown here

  1. ncbi Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
    D Lavanchy
    World Health Organization, Communicable Disease Surveillance and Response, Geneva, Switzerland
    J Viral Hepat 11:97-107. 2004
    b>Hepatitis B virus (HBV) infection is a serious global health problem, with 2 billion people infected worldwide, and 350 million suffering from chronic HBV infection...
  2. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
    ..5% of all cancer), the human papilloma viruses (5.2%), the hepatitis B and C viruses (4...
  3. ncbi Association between nucleoside analogues and risk of hepatitis B virus–related hepatocellular carcinoma recurrence following liver resection
    Chun Ying Wu
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    JAMA 308:1906-14. 2012
    ..Tumor recurrence is a major issue for patients with hepatocellular carcinoma (HCC) following curative liver resection...
  4. ncbi Hepatitis B virus infection--natural history and clinical consequences
    Don Ganem
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, USA
    N Engl J Med 350:1118-29. 2004
  5. pmc Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews
    Paul K Nelson
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia
    Lancet 378:571-83. 2011
    ..We estimated national, regional, and global prevalence and population size for hepatitis C virus (HCV) and hepatitis B virus (HBV) in injecting drug users (IDUs).
  6. ncbi Immunology of hepatitis B virus and hepatitis C virus infection
    Barbara Rehermann
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
    Nat Rev Immunol 5:215-29. 2005
    More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma...
  7. ncbi Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma
    Jian Huang
    Human Genome Center of Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 44:1117-21. 2012
    ..HCC is associated with multiple risk factors, including hepatitis B virus (HBV) infection, which is especially prevalent in China...
  8. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
    ..In hepatitis B virus (HBV)-related cirrhosis, the 5-year cumulative HCC risk is 15% in high endemic areas and 10% in the West...
  9. ncbi Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination
    Xiaofeng Liang
    Chinese Center for Disease Control and Prevention, Beijing, China
    Vaccine 27:6550-7. 2009
    To determine the prevalence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core anti-body (anti-HBc) in a representative population in China 14 years after introduction of hepatitis B ..
  10. pmc Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma
    De Ke Jiang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Nat Genet 45:72-5. 2013
    To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases ..
  11. pmc Hepatitis B virus biology
    C Seeger
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Microbiol Mol Biol Rev 64:51-68. 2000
    Hepadnaviruses (hepatitis B viruses) cause transient and chronic infections of the liver. Transient infections run a course of several months, and chronic infections are often lifelong...
  12. ncbi Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    Uchenna H Iloeje
    Global Epidemiology and Outcomes Research, Pharmaceutical Research Institute, Bristol Myers Squibb Company, Wallingford, Connecticut
    Gastroenterology 130:678-86. 2006
    Cirrhosis develops as a result of hepatic inflammation and subsequent fibrosis in chronic hepatitis B infection. We report on the relationship between hepatitis B viremia and progression to cirrhosis in chronic hepatitis B infection.
  13. pmc Hepatitis B and C virus infection and hepatocellular carcinoma in China: a review of epidemiology and control measures
    Masahiro Tanaka
    Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Epidemiol 21:401-16. 2011
    China has one of the highest carrier prevalences of hepatitis B virus (HBV) in the world: nearly 10% of the general population...
  14. pmc Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean
    Nao Nishida
    Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan
    PLoS ONE 7:e39175. 2012
    b>Hepatitis B virus (HBV) infection can lead to serious liver diseases, including liver cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85-90% of infected individuals become inactive carriers with sustained biochemical ..
  15. doi Hepatitis B virus infection
    Jules L Dienstag
    Gastrointestinal Unit Medical Services, Massachusetts General Hospital, and Department of Medicine and Office of the Dean for Medical Education, Harvard Medical School, Boston 02114, USA
    N Engl J Med 359:1486-500. 2008
  16. pmc Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients
    Severine Margeridon-Thermet
    Department of Medicine, Stanford University, Stanford, CA, USA
    J Infect Dis 199:1275-85. 2009
    The dynamics of emerging nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI) resistance in hepatitis B virus (HBV) are not well understood because standard dideoxynucleotide direct polymerase chain reaction (PCR) sequencing ..
  17. pmc Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    Carolina Boni
    Laboratorio Immunopatologia Virale, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Virol 81:4215-25. 2007
    ..We took advantage of the wide fluctuations in levels of viremia which are typical of chronic hepatitis B virus (HBV) infection to comprehensively analyze the impact of prolonged exposure to different virus quantities ..
  18. ncbi Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    Shunsuke Ura
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 49:1098-112. 2009
    ..chain reaction, we measured the expression of 188 miRNAs in liver tissues obtained from 12 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and 14 patients with hepatitis C virus (HCV)-related HCC, ..
  19. ncbi Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
    Julie Lucifora
    Institute of Virology, Technische Universität München Helmholtz Zentrum München, Trogerstrasse, 30, 81675 Munich, Germany
    J Hepatol 55:996-1003. 2011
    The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.
  20. pmc The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients
    Zhaoshi Jiang
    Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California 94080, USA
    Genome Res 22:593-601. 2012
    b>Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). HBV integration into the host genome has been reported, but its scale, impact and contribution to HCC development is not clear...
  21. pmc Pathogenesis of hepatitis B virus infection
    F V Chisari
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pathol Biol (Paris) 58:258-66. 2010
    The adaptive immune response is thought to be responsible for viral clearance and disease pathogenesis during hepatitis B virus infection...
  22. ncbi Global control of hepatitis B virus infection
    Jia Horng Kao
    Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    Lancet Infect Dis 2:395-403. 2002
    Worldwide about 350 million people are chronic carriers of the hepatitis B virus (HBV). The infection can cause acute and chronic liver disease including cirrhosis and hepatocellular carcinoma (HCC)...
  23. ncbi Occult hepatitis B virus infection
    Giovanni Raimondo
    Unit of Clinical and Molecular Hepatology, Department of Internal Medicine, University of Messina, 98124 Messina, Italy
    J Hepatol 46:160-70. 2007
    The persistence of hepatitis B virus (HBV) genomes in HBV surface antigen (HBsAg) negative individuals is termed occult HBV infection...
  24. ncbi Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    ..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...
  25. ncbi Role of reproductive factors in hepatocellular carcinoma: Impact on hepatitis B- and C-related risk
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Hepatology 38:1393-400. 2003
    ..factors on HCC risk, and to assess whether the association between each factor and HCC differs between hepatitis B surface antigen (HBsAg)-positive and -negative women, in which hepatitis C virus (HCV) is the major cause of ..
  26. pmc Detection of highly prevalent hepatitis B virus coinfection among HIV-seropositive persons in Ghana
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust and UCL Medical School, Pond Street, London NW3 2QG, United Kingdom
    J Clin Microbiol 48:3223-30. 2010
    Simple hepatitis B surface antigen (HBsAg) tests may facilitate ascertainment of hepatitis B virus (HBV) infection in settings with high endemicity but limited infrastructure...
  27. ncbi HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
    Chloe L Thio
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet 360:1921-6. 2002
    Although coinfection with HIV-1 and hepatitis B virus (HBV) is common, few long-term studies on liver-disease mortality in coinfected people have been undertaken...
  28. pmc Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
    Jean Pierre Vartanian
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS Pathog 6:e1000928. 2010
    DNA viruses, retroviruses and hepadnaviruses, such as hepatitis B virus (HBV), are vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3) cytidine deaminases...
  29. ncbi Hepatitis B virus genotypes
    Anna Kramvis
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193 Johannesburg, South Africa
    Vaccine 23:2409-23. 2005
    Eight genotypes of hepatitis B virus (A-H) are currently recognized, and subgenotypes have recently been described in four of these genotypes (A, B, C and F)...
  30. ncbi A mathematical model to estimate global hepatitis B disease burden and vaccination impact
    Susan T Goldstein
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1329-39. 2005
    Limited data are available regarding global hepatitis B virus (HBV)-related morbidity and mortality and potential reduction in disease burden from hepatitis B vaccination.
  31. ncbi Hepatitis B virus infection: epidemiology and vaccination
    Colin W Shepard
    Epidemiology Branch, Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Rev 28:112-25. 2006
    Worldwide, two billion people have been infected with hepatitis B virus (HBV), 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or hepatocellular carcinoma...
  32. ncbi Inhibition of hepatitis B virus replication by APOBEC3G
    Priscilla Turelli
    Department of Microbiology and Molecular Medicine and Frontiers in Genetics Research Program, University of Geneva, Switzerland
    Science 303:1829. 2004
  33. ncbi Epidemiology of hepatitis B and C viruses: a global overview
    Helen S Te
    Liver Transplantation, Center for Liver Diseases, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 7120, Chicago, IL 60637, USA
    Clin Liver Dis 14:1-21, vii. 2010
    This article reviews the prevalence, disease burden, genotype distribution, and transmission patterns of hepatitis B virus (HBV) and hepatitis C virus in the 6 World Health Organization regions...
  34. ncbi Control of cccDNA function in hepatitis B virus infection
    Massimo Levrero
    Department of Internal Medicine, Sapienza University of Rome, Policlinico Umberto I, 0061 Rome, Italy
    J Hepatol 51:581-92. 2009
    The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection...
  35. pmc Molecular and phylogenetic analyses suggest an additional hepatitis B virus genotype "I"
    Hai Yu
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China
    PLoS ONE 5:e9297. 2010
    A novel hepatitis B virus (HBV) strain (W29) was isolated from serum samples in the northwest of China...
  36. ncbi Impact of the implementation of a vaccination strategy on hepatitis B virus infections in China over a 20-year period
    Zhuanbo Luo
    National Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qing Chun Road, Hangzhou 310003, People s Republic of China
    Int J Infect Dis 16:e82-8. 2012
    b>Hepatitis B virus (HBV) vaccination has been recommended for all neonates in China since 1992. This article reviews the impact of HBV vaccination throughout the past 20 years in China...
  37. ncbi Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. Results of 3 consecutive respondent-driven sampling surveys in Beijing, 2004 through 2006
    Xiaoyan Ma
    Beijing Centers for Disease Control and Prevention, Beijing, China
    J Acquir Immune Defic Syndr 45:581-7. 2007
    ..We report on 3 consecutive cross-sectional surveys measuring the prevalence of HIV, other infectious diseases, and related risk behavior among MSM in Beijing in 2004, 2005, and 2006...
  38. ncbi Clinical implications of HIV and hepatitis B co-infection in Asia and Africa
    Christopher J Hoffmann
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet Infect Dis 7:402-9. 2007
    b>Hepatitis B virus (HBV) is the leading cause of chronic liver disease and liver-related death worldwide, with the majority of these cases occurring in areas of Africa and Asia where HBV prevalence is high...
  39. pmc A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection
    Rasmi Thomas
    Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA
    J Virol 86:6979-85. 2012
    Variants near the HLA-DP gene show the strongest genome-wide association with chronic hepatitis B virus (HBV) infection and HBV recovery/persistence in Asians...
  40. pmc A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication
    Yanni Chen
    State Key Laboratory of Virology and College of Life Sciences, Wuhan Institutes of Biotechnology, Chinese French Liver Disease Research Institute at Zhongnan Hospital, Wuhan University, Wuhan, China
    FASEB J 25:4511-21. 2011
    ..and progeny production are essential for persistent and chronic infection by human pathogens, such as hepatitis B virus (HBV), which affects >400 million people worldwide and is a major cause of liver disease...
  41. ncbi Dating the origin and dispersal of hepatitis B virus infection in humans and primates
    Dimitrios Paraskevis
    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece
    Hepatology 57:908-16. 2013
    The origin of hepatitis B virus (HBV) infection in humans and other primates remains largely unresolved...
  42. ncbi The changing epidemiology of viral hepatitis B in Iran
    Seyed Moayed Alavian
    Research Center for Gastroenterology and Liver Disease, University of Medical Sciences, Baqiyatallah, Vanaq Square, Mola Sadra St, Tehran, Iran
    J Gastrointestin Liver Dis 16:403-6. 2007
    b>Hepatitis B virus (HBV) prevalence has decreased dramatically in Iranian population during the last decade, and now our country is classified as having low endemicity for hepatitis B infection...
  43. pmc Use of massively parallel ultradeep pyrosequencing to characterize the genetic diversity of hepatitis B virus in drug-resistant and drug-naive patients and to detect minor variants in reverse transcriptase and hepatitis B S antigen
    Mariacarmela Solmone
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Virol 83:1718-26. 2009
    ..and reverse hybridization (line probe assay [LiPA])-based methods are the most common methods for detecting hepatitis B virus (HBV) drug resistance mutations, although only mutations present in viral quasispecies with a prevalence ..
  44. ncbi Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues
    Florian van Bömmel
    Medizinische Klinik m S Hepatologie und Gastroenterologie Charité, Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
    Hepatology 51:73-80. 2010
    ..disoproxil fumarate (TDF) has demonstrated high antiviral efficacy in treatment-naive patients with chronic hepatitis B virus (HBV) infection but experience in nucleoside/nucleotide analogue (NA)-experienced patients is limited...
  45. pmc Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    The risk of hepatocellular carcinoma (HCC) increases with increasing level of hepatitis B virus (HBV) in serum (viral load)...
  46. ncbi Prevalence of hepatitis B and hepatitis C virus infections in France in 2004: social factors are important predictors after adjusting for known risk factors
    Christine Meffre
    National Institute for Public Health Surveillance, Saint Maurice, France
    J Med Virol 82:546-55. 2010
    To monitor the prevalence of hepatitis B and hepatitis C a cross-sectional survey was conducted in 2004 among French metropolitan residents. A complex sampling design was used to enroll 14,416 adult participants aged 18-80 years...
  47. pmc New complex recombinant genotype of hepatitis B virus identified in Vietnam
    Thien Tuan Huy Tran
    Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:5657-63. 2008
    A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel intergenotypic recombination between genotypes A, C, and G. VH24 showed high similarity (98.3 to 98...
  48. pmc General epidemiological parameters of viral hepatitis A, B, C, and E in six regions of China: a cross-sectional study in 2007
    Jian Lu
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Xuanwu District, Beijing, People s Republic of China
    PLoS ONE 4:e8467. 2009
    ..Viral hepatitis is a serious health burden worldwide. To date, few reports have addressed the prevalence of hepatitis A, B, C, and E in China. Therefore, the general epidemiological parameters of viral hepatitis remain unknown...
  49. ncbi The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference*
    A Hatzakis
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece
    J Viral Hepat 18:1-16. 2011
    Worldwide, the hepatitis B virus (HBV) and the hepatitis C virus (HCV) cause, respectively, 600,000 and 350,000 deaths each year...
  50. pmc Possible new hepatitis B virus genotype, southeast Asia
    Christophe M Olinger
    National Public Health Laboratory Centre de Recherche Public Santé, Luxembourg, Luxembourg
    Emerg Infect Dis 14:1777-80. 2008
    We conducted a phylogenetic analysis of 19 hepatitis B virus strains from Laos that belonged to 2 subgenotypes of a new genotype I...
  51. pmc Mycotoxins and human disease: a largely ignored global health issue
    Christopher P Wild
    International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
    Carcinogenesis 31:71-82. 2010
    ..Aflatoxins are hepatocarcinogenic in humans, particularly in conjunction with chronic hepatitis B virus infection, and cause aflatoxicosis in episodic poisoning outbreaks...
  52. ncbi Effect of age on the incidence of acute hepatitis B after 25 years of a universal newborn hepatitis B immunization program in Taiwan
    Wei Ju Su
    Centers for Disease Control, Department of Health, Taipei, Taiwan
    J Infect Dis 205:757-62. 2012
    Raising concerns about the waning immunity of cohorts receiving hepatitis B virus (HBV) vaccination in infancy persuaded us to identify the changing incidence of acute hepatitis B (AHB) in children and young adults.
  53. pmc Association between hepatitis B virus and pancreatic cancer
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:4557-62. 2008
    b>Hepatitis B virus (HBV) and hepatitis C virus (HCV) are considered to be hepatotropic and are a major cause of hepatocellular carcinoma. However, little is known about the role of HBV and HCV infection in other malignancies...
  54. ncbi Prevalence of hepatitis B in the southeast of China: a population-based study with a large sample size
    Zhuanbo Luo
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People s Republic of China
    Eur J Gastroenterol Hepatol 23:695-700. 2011
    b>Hepatitis B is a major public health problem in China. However, in the past 10 years, estimates of the prevalence of hepatitis B virus (HBV) have been sparse, with results that do not always agree...
  55. ncbi Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch-up immunization program
    Brian J McMahon
    Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
    Hepatology 54:801-7. 2011
    Alaska Native people experience the highest rates of acute and chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) in the United States...
  56. pmc Prevalence of hepatitis B in insular regions of southeast China: a community-based study
    Ping Chen
    The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China
    PLoS ONE 8:e56444. 2013
    b>Hepatitis B virus (HBV) infection remains a significant public health problem...
  57. pmc Risk factors for syphilis and prevalence of HIV, hepatitis B and C among men who have sex with men in Beijing, China: implications for HIV prevention
    Yuhua Ruan
    Epidemiology and Biostatistics Branch, Division of Virology and Immunology, State Key Laboratory for Infectious Disease Prevention and Control, NCAIDS, Chinese CDC, Beijing 100050, People s Republic of China
    AIDS Behav 13:663-70. 2009
    To examine the correlates for syphilis and the prevalence for HIV, hepatitis B, hepatitis C among men-who-have-sex-with-men (MSM) in Beijing, China. A total of 541 MSM was recruited using peer-referral, community outreach, and Internet...
  58. ncbi Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    Dongping Xu
    Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China
    J Immunol 177:739-47. 2006
    ..In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B (CHB)...
  59. ncbi Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study
    De zhong Xu
    Department of Epidemiology, Fourth Military Medical University, Xi an, China
    J Med Virol 67:20-6. 2002
    Intrauterine hepatitis B virus (HBV) infection has been suggested to be caused by transplacental transmission that cannot be blocked by hepatitis B vaccine. This would decrease the effectiveness of hepatitis B vaccine...
  60. ncbi Hepatocyte polarization is essential for the productive entry of the hepatitis B virus
    Andreas Schulze
    Department of Infectious Diseases, Molecular Virology, Otto Meyerhof Zentrum, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 55:373-83. 2012
    Human hepatitis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism. Within the liver, HBV replication occurs in differentiated and polarized hepatocytes...
  61. ncbi Increasing burden of liver disease in patients with HIV infection
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Lancet 377:1198-209. 2011
    ..have been accompanied by an increase in liver-related morbidity and mortality due to co-infection with chronic hepatitis B and C viruses...
  62. ncbi Hepatitis B in China
    Jie Liu
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    Lancet 369:1582-3. 2007
  63. ncbi Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
    Hang Li
    Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Hepatology 56:1342-51. 2012
    ..Here we studied the expression, function, and regulation of the Tim-3/galectin-9 pathway in patients with hepatitis B virus (HBV)-associated HCC...
  64. pmc A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers
    Johannes Vermehren
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    PLoS ONE 7:e32605. 2012
    Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide...
  65. ncbi Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection
    Yu Tse Tsan
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, 17 Syujhou Rd, Taipei 10055, Taiwan
    J Clin Oncol 30:623-30. 2012
    Statins have potential protective effects against cancers, but no studies have focused on patients with chronic hepatitis B virus (HBV) infection...
  66. ncbi Minimization of hepatitis B infection by a 25-year universal vaccination program
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 57:730-5. 2012
    b>Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984...
  67. ncbi Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 95:1485-8. 2003
    Chronic infection with hepatitis B virus (HBV) causes DNA damage. An arginine (Arg)-to-glutamine (Gln) polymorphism at codon 399 in the XRCC1 gene is putatively associated with DNA damage...
  68. ncbi Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin
    Jin Feng Huang
    The Department of Medical Genetics, Second Military Medical University, Shanghai, China
    Hepatology 57:1882-92. 2013
    The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear...
  69. ncbi Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
    Jinfeng Huang
    Department of Medical Genetics, Second Military Medical University, Shanghai, People s Republic of China
    Hepatology 52:60-70. 2010
    The hepatitis B virus (HBV) X protein has been implicated as a potential trigger of the epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying mechanisms remain unknown...
  70. pmc Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study
    Jin Li
    Institute of Liver Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    PLoS ONE 6:e24221. 2011
    Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand...
  71. ncbi Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha
    Maya Mouler Rechtman
    The Institute of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    FEBS Lett 584:2485-90. 2010
    b>Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy...
  72. pmc Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 West 168th Street, RM19 418, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 18:846-53. 2009
    ..57 (0.14-2.43), 1.43 (0.32-6.42), and 4.91 (1.18-20.48; Ptrend=0.02), respectively, among noncarriers of hepatitis B virus (HBV) infection. The adjusted OR (95% CI) was 7.49 (5.13-10...
  73. ncbi Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus
    Anna Kramvis
    MRC CANSA University Molecular Hepatology Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Med Virol 80:27-46. 2008
    Using phylogenetic analysis and pairwise comparison of 670 complete hepatitis B virus (HBV) genomes, we demonstrated that nucleotide divergence greater than 7.5% can be used to separate strains into genotypes A-H...
  74. pmc A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus
    Ye Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Gastroenterology 141:1897-906. 2011
    ..IL-22 induces expression of proinflammatory genes but is also mitogenic and antiapoptotic in hepatocytes. Therefore, it could have multiple functions in the immune response to hepatitis B virus (HBV).
  75. pmc Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner
    Josef Kock
    Department of Medicine II, University Hospital of Freiburg, Freiburg, Germany
    PLoS Pathog 6:e1001082. 2010
    Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes ..
  76. ncbi Hepatitis B vaccines: protective efficacy and therapeutic potential
    M L Michel
    Laboratoire de pathogenèse des virus de l hépatite B, Institut Pasteur, Batiment Lwoff, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Pathol Biol (Paris) 58:288-95. 2010
    Worldwide, two billion people have at some time been infected by hepatitis B virus, 370 millions suffer from chronic infection and around one million die each year from HBV-related liver diseases of which liver cancer is the ultimate ..
  77. ncbi The global impact of vaccination against hepatitis B: a historical overview
    Alessandro R Zanetti
    Department of Public Health Microbiology Virology, Faculty of Medicine, University of Milan, Via C Pascal 36, 20133 Milan, Italy
    Vaccine 26:6266-73. 2008
    b>Hepatitis B virus (HBV) infection is a world wide public health problem of major concern. HBV infection may lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC)...
  78. pmc Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients
    Tong V Hoang
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    PLoS ONE 6:e28113. 2011
    ..We genotyped a Vietnamese cohort comprising of 423 clinically classified hepatitis B virus patients and 303 controls for functional single nucleotide polymorphisms in the promoter region (-986G>..
  79. pmc Ethnogeographical structure of hepatitis B virus genotype distribution in Indonesia and discovery of a new subgenotype, B9
    Meta Dewi Thedja
    Eijkman Institute for Molecular Biology, Jakarta, Indonesia
    Arch Virol 156:855-68. 2011
    The distribution of hepatitis B virus (HBV) in the populations of island Southeast Asia is of medical and anthropological interest and is associated with an unusually high genetic diversity...
  80. ncbi Viral hepatitis B
    Ching Lung Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Lancet 362:2089-94. 2003
    More than 400 million people worldwide are chronically infected by the hepatitis B virus. The virus is responsible for more than 300000 cases of liver cancer every year and for similar numbers of gastrointestinal haemorrhage and ascites...
  81. ncbi Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma
    Hui Chuan Sun
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
    J Hepatol 47:684-90. 2007
    To study the impact of hepatitis B e antigen on tumor recurrence and patients' survival after curative resection of hepatocellular carcinoma.
  82. pmc CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    Robert Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:68-76. 2003
    Although the CD4(+)- and CD8(+)-T-cell responses to the hepatitis B virus (HBV) are thought to be crucial for the control of HBV infection, the relative contribution of each T-cell subset as an effector of viral clearance is not known...
  83. ncbi Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China
    Xiaofeng Liang
    Chinese Center for Disease Control and Prevention, Beijing, China
    J Infect Dis 200:39-47. 2009
    Endemic hepatitis B virus (HBV) infection is a serious health problem in China. Hepatitis B vaccination of infants was introduced in 1992 and was progressively expanded during the subsequent 15 years.
  84. ncbi Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, Hannover, Germany
    J Hepatol 52:514-22. 2010
    The quantifiable level of HBsAg has been suggested as a predictor of treatment response in chronic hepatitis B. However, there is limited information on HBsAg levels considering the dynamic natural course of HBV-infection...
  85. ncbi Interaction of hepatitis B virus, chemical carcinogen, and genetic susceptibility: multistage hepatocarcinogenesis with multifactorial etiology
    Chien Jen Chen
    Hepatology 36:1046-9. 2002
  86. ncbi The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study
    Shahin Merat
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 12:225-31. 2009
    b>Hepatitis B virus infection is a very common cause of chronic liver disease worldwide. It is estimated that 3% of Iranians are chronically infected with hepatitis B virus...
  87. ncbi Epidemiology, risk factors, and natural history of hepatocellular carcinoma
    Giuseppe Montalto
    Institute of Internal Medicine, Institute of Development Biology, CNR, University of Palermo, Palermo, Italy
    Ann N Y Acad Sci 963:13-20. 2002
    ..reflects the epidemiologic impact of the main etiologic factors and environmental risk, which are the hepatitis B (HBV) and hepatitis C (HCV) viruses...
  88. ncbi Hepatitis B virus genetic variability and evolution
    Alan Kay
    INSERM, U871, Physiopathologie moléculaire et nouveaux traitements des hépatites virales, 151 Cours A Thomas, Lyon F 69424, France
    Virus Res 127:164-76. 2007
    b>Hepatitis B virus has been evolving gradually over a long period of time, resulting in a large amount of genetic diversity, despite the constraints imposed by the complex genetic organization of the viral genome...
  89. ncbi Occult hepatitis B in HIV-infected patients
    Norah J Shire
    University of Cincinnati College of Medicine, OH 45267, USA
    J Acquir Immune Defic Syndr 36:869-75. 2004
    Prevalence of hepatitis B virus (HBV) markers, including occult HBV, has not been described in diverse cohorts among HIV-infected patients...
  90. ncbi Practical difficulties in the management of hepatitis B in the Asia-Pacific region
    Rosmawati Mohamed
    Department of Medicine, University Malaya, Kuala Lumpur, Malaysia
    J Gastroenterol Hepatol 19:958-69. 2004
    The Asia-Pacific Expert Committee on Hepatitis B Management recently reviewed the impact of hepatitis B in the region and assessed the differences and similarities observed in the practical management of the disease in individual Asia-..
  91. pmc Rapid and sensitive assays for determination of hepatitis B virus (HBV) genotypes and detection of HBV precore and core promoter variants
    Munira Hussain
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    J Clin Microbiol 41:3699-705. 2003
    b>Hepatitis B virus (HBV) genotypes may influence HBeAg seroconversion rates, mutational patterns in the precore (PC) and core promoter (CP) regions, severity of liver disease, and response to antiviral treatment...
  92. pmc Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model
    Yi Jiun Lin
    Graduate Institute of Microbiology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 10002, Taiwan
    Proc Natl Acad Sci U S A 107:9340-5. 2010
    We recently developed a mouse model of hepatitis B virus (HBV) persistence, in which a single i.v...
  93. ncbi Traditional Chinese medicine and related active compounds against hepatitis B virus infection
    Xiaoyan Cui
    Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
    Biosci Trends 4:39-47. 2010
    b>Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide...
  94. pmc Eliminating the blood: ongoing outbreaks of hepatitis B virus infection and the need for innovative glucose monitoring technologies
    Nicola D Thompson
    Epidemiology and Surveillance Branch, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Diabetes Sci Technol 3:283-8. 2009
    ..In settings where multiple persons require assistance with blood glucose monitoring, opportunities for bloodborne pathogen transmission may exist...
  95. ncbi Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-κB
    Xingfei Pan
    Department of Infectious Diseases, The 3rd Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, People s Republic of China
    Mol Immunol 48:1573-7. 2011
    ..However, the role of HBV in IL-32 expression remains unclear. In the present study, we demonstrate that hepatitis B virus protein X (HBx) increases IL-32 expression through the promoter of IL-32 at positions from -746 to +25 ..
  96. pmc Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection
    Priscilla L Yang
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:13825-30. 2002
    b>Hepatitis B virus (HBV) is a prototype for liver-specific pathogens in which the failure of the immune system to mount an effective response leads to chronic infection...
  97. ncbi Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    Patrizia Paterlini-Brechot
    INSERM Pasteur Unit 370, Necker Faculty of Medicine, Necker Enfants Malades Hospital, Paris 75015, France
    Oncogene 22:3911-6. 2003
    Integration of Hepatitis B Virus (HBV) DNA into liver cell DNA has been well established, but its implication in liver carcinogenesis is still being debated...
  98. ncbi Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China: a possible role of hepatitis B virus
    Ning Fu Peng
    Department of Hepatobiliary Surgery, Guangxi Medical University, Guangxi Province, China
    Ann Surg Oncol 18:1258-66. 2011
    Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor cell in ICC development, without definitive conclusions...
  99. ncbi Frequencies of hepatitis B and C infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: analysis of registry data
    David W Johnson
    Australia and New Zealand Dialysis and Transplant Registry, Discipline of Public Health, University of Adelaide, Adelaide, Australia
    Nephrol Dial Transplant 24:1598-603. 2009
    ..The aim of the present investigation was to evaluate the rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in peritoneal dialysis (PD) and haemodialysis (HD) patients in the Asia-Pacific region.
  100. ncbi Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study
    W M Xu
    Shanghai Infectious Disease Hospital, Shanghai, China
    J Viral Hepat 16:94-103. 2009
    ..double-blind, placebo-controlled study evaluated whether lamivudine given during late pregnancy can reduce hepatitis B virus (HBV) perinatal transmission in highly viraemic mothers...
  101. ncbi The worldwide impact of vaccination on the control and protection of viral hepatitis B
    Luisa Romano'
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Milano, Italy
    Dig Liver Dis 43:S2-7. 2011
    Viral hepatitis B is a leading cause of acute and chronic liver disease worldwide, including cirrhosis and hepatocellular carcinoma...

Research Grants74

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Specific transfusion protocols are followed and all transfused patients are screened annually for hepatitis B surface antibody, surface antigen and core antibody and HIV...
  2. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..b>Hepatitis B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and ..
  3. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..serodiagnostic antigens for non-biodefense targets including: Bartonella henselae, Borrelia burgdorferi, Hepatitis B Virus, Chlamydia, Plasmodium falciparum, Human papillomavirus, and Herpes simplex virus...
  4. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..The numbers of annual deaths due to infections by Salmonella Typhi and S. Paratyphi A, hepatitis B virus (HBV), Streptococcus pneumoniae and Mycobacterium tuberculosis (Mtb) vary widely but may account for ..
  5. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..panels and submission, and community health forums;2) research topics - to include diet, smoking cessation, hepatitis B, occupational exposure reduction, comparative- and cost-effectiveness of mobile mammography, and breast, ..
  6. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..both wild type and chimeric VLPs will be evaluated in delivery of DNA vaccine encoding the surface antigen of hepatitis B virus, as potential gene carrier for treatment of chronic progressive hepatitis B...
  7. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is the most common cause of chronic viral liver disease worldwide...
  8. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..With a continuing focus on the roles of infection with hepatitis B virus and co-exposure to the fungal toxin aflatoxin on human risk for hepatocellular carcinoma, we will purse ..
  9. Mechanism(s) of Hepatocyte Transformation by the Hepatitis B Virus X Protein
    Ourania M Andrisani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic Hepatitis B Virus (HBV) infection is a major factor in the pathogenesis of hepatocellular carcinoma (HCC)...
  10. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus (HBV) infection affects approximately 350 million people worldwide and is a significant risk factor for severe liver disease, including hepatocellular carcinoma (HCC)...
  11. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    ..sex hormone testosterone may play a role in increasing risk of liver cancer due to another viral infection, Hepatitis B virus...
  12. Structure and Function of the Hepatitis C Virus Genome
    Peter Sarnow; Fiscal Year: 2013
    ..80% of hepatocellular carcinoma, a leading cause of cancer-related deaths, is caused by infection with either hepatitis B or hepatitis C virus (HCV)...
  13. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..Its major risk factors are infection with hepatitis B and C viruses, and exposure to toxic chemicals, including alcohol, all of which cause chronic liver injury and ..
  14. Double Humanization of Liver and Blood in Mice
    ELIZABETH MARIE WILSON; Fiscal Year: 2012
    ..The applications include studies of human infectious diseases (hepatitis B and B, malaria etc...
  15. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..affecting tens of millions of patients worldwide, is the liver scarring response to chronic injury from viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, ..
  16. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..compared with adjacent non-tumor tissues, and test whether the miRNA methylation levels are different for hepatitis B virus (HBV) and hepatitis C virus (HCV)-related HCC;(2) To examine whether a subgroup of miRNA genes showing ..
  17. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    There are an estimated 350 million people worldwide who are chronically infected with hepatitis B virus (HBV) and are at high risk for the development of hepatitis, cirrhosis (end stage liver disease) and hepatocellular carcinoma (HCC)...
  18. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..High risk factors include chronic infection with hepatitis B (HBV) and C viruses (HCV), while additional risk factors include exposure to tobacco smoke...
  19. A Targeted Preemptive Approach to Addressing Mitochondrial Toxicity of Nucleoside
    John K Buolamwini; Fiscal Year: 2013
    ..antiviral nucleoside drugs such as fialuridine (FIAU) and clevudine (L-FMAU) that were being developed to treat hepatitis B (HBV) infections, and gemcitabine, the drug of choice for the treatment of pancreatic cancer...
  20. Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car
    Ourania M Andrisani; Fiscal Year: 2010
    Chronic Hepatitis B virus (HBV) infection is linked to hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis by an unknown mechanism...
  21. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..Epidemiological studies have suggested that hepatitis B virus infection and dietary aflatoxin B1 (AFB1) are the two major etiological agents for human HCC...
  22. Liver cancer risk and prevention among persons living with HIV/AIDS
    LESLEY SUEJEAN PARK; Fiscal Year: 2013
    ..this population, impaired immune function, and high prevalence of liver cancer risk factors hepatitis C virus, hepatitis B virus, an alcohol abuse and dependency contribute to the rising incidence of liver cancer among PLWHA...
  23. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..due to aging (lymphoid atrophy), autoimmune diseases, genetic causes (such as SCID), infectious diseases (HIV, hepatitis B/C), corticosteroids, shock, radio- or chemo-therapy and radiation injury (nuclear accident or terrorism).
  24. Modeling distinct neonatal purine metabolism to inform vaccine development
    Ofer Levy; Fiscal Year: 2013
    ..the novel NTC, interrogating the ability of adjuvants and vaccines, such as Bacillus Calmette-Guerin (BCG), hepatitis B vaccine, and pneumoccal conjugate vaccine to induce ADA, modulate Ado levels, and trigger differentiation and ..
  25. Novel Therapeutic Vaccines for Chronic HBV
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that results in a self-limited acute infection in a majority of otherwise healthy individuals but can also cause chronic infection, ..
  26. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..the efficacy, safety and tolerance of each of two drugs, tenofovir and lamivudine, versus placebo, given to hepatitis B (HB) chronically infected pregnant women with a positive HBeAg test and normal liver function tests, from 28 ..
  27. Antisense Mediated Treatment of Hepatitis B Virus Infection
    STEFAN FRANK WIELAND; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that causes acute and chronic hepatitis and kills a million people each year from cirrhosis of the liver and hepatocellular ..
  28. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The liver is also a target for persistent viral infections, such as chronic infections with the hepatitis B virus (HBV)...
  29. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma (HCC)...
  30. Hepatic Non-viral Gene Therapy
    Leaf Huang; Fiscal Year: 2013
    ..Over 2 billion people have been infected with the hepatitis B virus (HBV) and 350 million live with chronic HBV infection worldwide, about 25% of whom die from liver ..
  31. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis C and hepatitis B virus infections in humans are characterized by hepatocellular necrosis, inflammation, and development of hepatoma...
  32. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2011
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human ..
  33. Role of Hepatitis B virus X protein in HBV replication
    Michael J Bouchard; Fiscal Year: 2011
    Individuals with a chronic hepatitis B virus (HBV) infection of the liver have an increased risk for developing hepatocellular carcinoma (HCC)...
  34. Hepatitis B virus X protein modulation of calcium signaling in HCC development
    JESSICA GARNER; Fiscal Year: 2013
    ..to exposure to various toxins or infectious agents, the majority of HCC cases are associated with chronic hepatitis B virus (HBV) infections...
  35. Identifying a role for commensal bacteria on the liver immune priming environment
    Jean Publicover; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a partially double-stranded DNA virus that causes acute and hepatitis in humans...
  36. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus, hepatitis C virus, hepatitis A virus, respiratory syncytial virus, and human immunodeficiency virus and ..
  37. Role of Pellino1 in liver inflammation
    Liselotte E Jensen; Fiscal Year: 2010
    ..It is estimated that over 2 billion people worldwide are infected with hepatitis B virus (HBV) or hepatitis C virus (HCV)...
  38. ROLE OF WNT SIGNALING IN CHRONIC ALCOHOLIC LIVER DISEASE
    Miran Kim; Fiscal Year: 2013
    ..Moreover, ALD either additively or synergistically contributes to liver failure in patients with chronic hepatitis B or C viral infections...
  39. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..provided by applicant): The human liver serves as the reservoir for several important pathogens, including hepatitis B (HBV) and C viruses (HCV) and the malaria parasites, all of which represent serious global health problems...
  40. NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE
    BRIAN JAMES MCMAHON; Fiscal Year: 2012
    Infections from hepatitis A virus (HAV) and hepatitis B virus (HBV) are significant problems in Alaska Natives. Hepatitis A and B vaccines have been routine immunizations in Alaska Natives since 1984 and 1994, respectively...
  41. Pathogenesis of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2011
    Many viral infections induce liver pathology, and the association of infection, by hepatitis B virus and hepatitis C virus, with the development of cirrhosis and hepatoma in humans, highlights the need to understand mechanisms regulating ..
  42. The Environment as a Variable to Calibrate Mouse Models of Human Disease
    John M Essigmann; Fiscal Year: 2013
    ..an established risk factor for human hepatocellular carcinoma that strongly elevates risk in synergy with hepatitis B virus infection...
  43. Biological Markers of Aflatoxin Exposure and Methylation
    Regina M Santella; Fiscal Year: 2013
    ..In ongoing studies, we demonstrated that, in conjunction with hepatitis B or C virus infection, elevated levels of biomarkers of aflatoxin B1 (AFB1) and polycyclic aromatic hydrocarbon (..
  44. IeDEA West -Africa collaboration
    Francois Dabis; Fiscal Year: 2013
    ..the following topics: retention in care, natural history of HIV-2 and HIV-1/HIV-2 infections, cancer, malaria, hepatitis B, pregnancy outcomes, pharmacovigilance, adolescent and pediatric access and efficiency of care...
  45. Discovery of novel anti-HBV compounds targeting host factors
    Pavel A Petukhov; Fiscal Year: 2013
    ..approach to discover lead candidates suitable for further lead optimization as therapeutics for chronic hepatitis B virus (HBV) infections...
  46. Mechanism of CCC DNA Synthesis in Hepatitis B Virus
    Christoph Seeger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Investigations on hepatitis B virus (HBV) and related animal viruses, particularly duck hepatitis B virus (DHBV), have provided a detailed model of the hepadnavirus replication cycle...
  47. HBx regulation of miRNA-mediated mRNA silencing in HCC development.
    RICHARD JASON LAMONTAGNE; Fiscal Year: 2013
    ..It is known however, that chronic infection with the hepatitis B virus (HBV) is one of the leading risk factors for developing HCC...
  48. MOLECULAR MANIPULATION TO ENHANCE ANTI-MYELOMA RESPONSE
    Nikhil C Munshi; Fiscal Year: 2013
    ..We evaluated development of immune response to Hepatitis B vaccination in patients with MM and monoclonal gammopathy of undetermined significance (MGUS) and observed that ..
  49. 10-Theory and Experiment for Genome Packaging in HBV Nucleocapsids
    JIANZHONG contact WU; Fiscal Year: 2010
    ..Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Hepatitis B virus (HBV) infects more than 2 billion people alive today and is responsible for over 1 million deaths caused ..
  50. Liver Inflammation and Injury: Molecular Mechanisms
    Mario Chojkier; Fiscal Year: 2013
    ..burden of liver diseases to the Veteran's Administration is substantial, as it is associated with Hepatitis B and C, rejection of a transplanted liver, auto-immune hepatitis, fatty liver of obesity and diabetes and ..
  51. Regulation of CD8 T Cell Immunity by CDK Inhibitor p27Kip1
    Marulasiddappa Suresh; Fiscal Year: 2012
    ..provided by applicant): CD8 T cells play a crucial role in defense against viral infections like HIV, hepatitis B and C, Epstein Barr virus, cytomegalovirus, and arenaviruses...
  52. Virologic and Serologic Outcomes of Persons with HIV and HBV co-infection on Mono
    JUDITH ANN ABERG; Fiscal Year: 2010
    ..Among those with HBV mono-infection, HBe seroconversion from the state of Hepatitis B e antigen (HBeAg) positive chronic hepatitis to an "inactive" or "carrier" state (HBeAg negative) has ..
  53. A New Low Power Low Cost Ozone Sterilizer for Medical Equipment
    Joseph R Stetter; Fiscal Year: 2012
    ..as a miniature, low power and low cost platform capable of decontamination of viral pathogens such as HIV, Hepatitis B and Hepatitis C (HBV, HCV)...
  54. Hepatitis B Virus PreS2 Mutant as Risk Factor for Hepatocellular Carcinoma
    Eric J Huang; Fiscal Year: 2010
    ..b>Hepatitis B virus (HBV) is a major cause of serious liver diseases, including chronic hepatitis, cirrhosis and ..
  55. Validity of Self-Reported Adult Vaccination Status
    SHARON L ROLNICK; Fiscal Year: 2010
    ..of the vaccinations, such as tetanus/diphtheria, pneumococcal polysaccharide vaccine, and the hepatitis A and hepatitis B series, may have been administered 10-15 years before the survey is answered, thereby increasing the likelihood ..
  56. Intervention of HBV DNA synthesis and transcription
    Aleem Siddiqui; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus infections affect about 300 million people worldwide and constitute a significant risk factor for fibrosis and hepatocellular carcinoma (HCC)...
  57. An infrastructure for cancer virus discovery from next-generation sequencing data
    Matthew L Meyerson; Fiscal Year: 2010
    ..In recent years, hepatitis B vaccination has led to a dramatic decrease in the occurrence of liver cancer, and human papillomavirus ..
  58. Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
    Hee Soon Juon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) infection is globally most common and serious viral infection of the liver. It can cause premature death from liver diseases or liver cancer...
  59. The RB pathway in liver cancer
    Julien Sage; Fiscal Year: 2013
    ..The environmental factors that cause HCC are well known and include infection by hepatitis B and C viruses (HBV and HCV), exposure to Aflatoxin B1, and excessive alcohol intake...
  60. Metabolic control of hepatitis B virus (HBV) biosynthesis: role of FXR and SHP
    VANESSA CURRAGH REESE; Fiscal Year: 2010
    This fellowship will support the study of the metabolic control of hepatitis B virus (HBV) biosynthesis...
  61. PDGFR and KDR Inhibitors for Liver Fibrosis
    Bert Oehlen; Fiscal Year: 2010
    ..affecting tens of millions of patients worldwide, is the liver scarring response to chronic injury from viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, ..
  62. Occult Hepatitis B Infection in South African HIV Patients
    Jason T Blackard; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Globally, 350 million people are chronically infected with hepatitis B virus (HBV) - the world's leading cause of cirrhosis and hepatocellular carcinoma (HCC)...
  63. Plant-Derived hepatitis B Vaccine from Biomanufacturing System to Clinical Trial
    Robert Britt; Fiscal Year: 2009
    ..In the current application we provide an example of a plant-made-pharmaceutical (recombinant hepatitis B vaccine) that we propose to take all the way from large scale controlled containment growth, secondary ..
  64. DRW HIV-Ab/HBsAg Duplex Rapid Test submission for FDA-PMA approval
    Helen Lee; Fiscal Year: 2009
    ..detect antibodies to HIV (HIV-Ab) for diagnosis of human immunodeficiency virus (HIV) infection and hepatitis B surface antigen (HBsAg) for diagnosis of hepatitis B virus (HBV) infection...
  65. CD07-005, Translating Research into the Jade Ribbon Campaign
    Samuel So; Fiscal Year: 2009
    ..Major gaps exist in the timely identification and immunization of infants born to women infected with hepatitis B virus (HBV)...
  66. An HBV polymerase RNA binding assay suitable for inhibitor screening
    Feng Cao; Fiscal Year: 2009
    b>Hepatitis B virus (HBV) is a hepatotropic DNA virus that replicates by reverse transcription. It chronically infects over 350 million people worldwide and causes 600,000 deaths annually...
  67. 2010 Molecular Biology of Hepatitis B Viruses Meeting
    Adam Zlotnick; Fiscal Year: 2010
    ..by applicant): Approximately 25% of the earth's population, 2 billion people, have been infected by Hepatitis B Virus (HBV). Approximately 360 million people suffer from chronic infection...
  68. HEPATITIS B VIRUS - CHRONIC HEPATITIS - LIVER CANCER
    DAVID SHAFRITZ; Fiscal Year: 1991
    Our overall goal is to study regulation of hepatitis B virus (HBV) gene expression and events in virus replication in human, animal model and cell culture systems and to investigate mechanisms whereby persistent infection with hepatitis ..
  69. Liver Disease and Drug Use in the HAART Era
    Chloe Thio; Fiscal Year: 2009
    ..of morbidity and mortality of HIV-infected individuals in the HAART era, which is primarily due to chronic hepatitis B and C infections...
  70. Structural Studies of HBsAg: Support for Quentin Florence
    QUENTIN FLORENCE; Fiscal Year: 2009
    DESCRIPTION (provided by investigator): Hepatitis B virus (HBV) is a blood-born-associated virus that has infected over 2 billion people worldwide. It is also one of the major causes of liver cancer...
  71. RECURRENT HEPATITIS B AFTER LIVER TRANSPLANTATION
    Anna Lok; Fiscal Year: 2007
    b>Hepatitis B accounts for approximately 5000 deaths/yr in the United States. Early results with orthotopic liver transplantation (OLT) for hepatitis B were poor with recurrence rates of >80% and 2-year mortality rates of 50%...
  72. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) remains a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV is a member of the hepadnavirus group, double-stranded DNA viruses...
  73. Antiviral/Antitumor Roles of Ganoderma Lucidum Spores
    Rui Liu; Fiscal Year: 2005
    Over 350 million people worldwide are chronic carriers of hepatitis B virus (HBV) - over one million in the United States alone. Chronic hepatitis B infection is a major risk for the development of primary hepatocellular carcinoma (HCC)...
  74. RANDOMIZED HEPATITIS B VACCINE DELIVERY TRIAL FOR IDUS
    Karen Seal; Fiscal Year: 2000
    ..and retaining injected drug users (IDUs) in a six-month program to provide them with a full series of three hepatitis B vaccine doses...