hepatitis a

Summary

Summary: INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.

Top Publications

  1. pmc General epidemiological parameters of viral hepatitis A, B, C, and E in six regions of China: a cross-sectional study in 2007
    Jian Lu
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Xuanwu District, Beijing, People s Republic of China
    PLoS ONE 4:e8467. 2009
  2. pmc Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein
    Mauro Costa-Mattioli
    Laboratorie de Virologie UPRES EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, 44093 Nantes, France
    J Virol 76:9516-25. 2002
  3. ncbi Seroepidemiology of hepatitis A and E virus infections in Tehran, Iran: a population based study
    Seyed Reza Mohebbi
    The Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 7th Floor, Taleghani Hospital, Yaman Ave, Velenjak, PO Box 19835 187, Tehran, Iran
    Trans R Soc Trop Med Hyg 106:528-31. 2012
  4. ncbi Hepatitis A virus infections in the United States: model-based estimates and implications for childhood immunization
    Gregory L Armstrong
    Epidemiology Branch, Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Pediatrics 109:839-45. 2002
  5. ncbi Changing risk profile of hepatitis A in The Netherlands: a comparison of seroprevalence in 1995-1996 and 2006-2007
    L Verhoef
    National Institute for Public Health and the Environment, Center for Infectious Disease Control, Laboratory for Infectious Diseases and Perinatal Screening, Bilthoven, The Netherlands
    Epidemiol Infect 139:1172-80. 2011
  6. ncbi Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals
    S Vento
    Infectious Diseases Unit, A Pugliese Hospital, Catanzaro, Italy
    Lancet 337:1183-7. 1991
  7. pmc Declining hepatitis A seroprevalence: a global review and analysis
    K H Jacobsen
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Epidemiol Infect 132:1005-22. 2004
  8. pmc Multilevel analysis of hepatitis A infection in children and adolescents: a household survey in the Northeast and Central-west regions of Brazil
    Ricardo Arraes de Alencar Ximenes
    State University of Pernambuco, School of Medical Sciences, Oswaldo Cruz University Hospital, Recife, PE, Brazil
    Int J Epidemiol 37:852-61. 2008
  9. ncbi Hepatitis A virus seroprevalence by age and world region, 1990 and 2005
    Kathryn H Jacobsen
    Department of Global and Community Health, George Mason University, 4400 University Drive MS 5B7, Fairfax, VA 22030, USA
    Vaccine 28:6653-7. 2010
  10. pmc Epidemiology and genetic characterization of hepatitis A virus genotype IIA
    Delphine Desbois
    centre national de Référence pour les virus des hépatites à transmission entérique, AP HP, Hopital Paul Brousse, Villejuif 94804, France
    J Clin Microbiol 48:3306-15. 2010

Detail Information

Publications390 found, 100 shown here

  1. pmc General epidemiological parameters of viral hepatitis A, B, C, and E in six regions of China: a cross-sectional study in 2007
    Jian Lu
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Xuanwu District, Beijing, People s Republic of China
    PLoS ONE 4:e8467. 2009
    Viral hepatitis is a serious health burden worldwide. To date, few reports have addressed the prevalence of hepatitis A, B, C, and E in China. Therefore, the general epidemiological parameters of viral hepatitis remain unknown.
  2. pmc Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein
    Mauro Costa-Mattioli
    Laboratorie de Virologie UPRES EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, 44093 Nantes, France
    J Virol 76:9516-25. 2002
    b>Hepatitis A virus (HAV) is a positive-stranded RNA virus in the genus Hepatovirus in the family Picornaviridae So far, analysis of the genetic variability of HAV has been based on two discrete regions, the VP1/2A junction and the VP1 N ..
  3. ncbi Seroepidemiology of hepatitis A and E virus infections in Tehran, Iran: a population based study
    Seyed Reza Mohebbi
    The Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 7th Floor, Taleghani Hospital, Yaman Ave, Velenjak, PO Box 19835 187, Tehran, Iran
    Trans R Soc Trop Med Hyg 106:528-31. 2012
    b>Hepatitis A virus (HAV) and hepatitis E virus (HEV) are enteric hepatotropic viruses and their prevalence is related to the sanitary conditions of the region under investigation...
  4. ncbi Hepatitis A virus infections in the United States: model-based estimates and implications for childhood immunization
    Gregory L Armstrong
    Epidemiology Branch, Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Pediatrics 109:839-45. 2002
    The high prevalence of antibody to hepatitis A virus (HAV) in the US population suggests that the incidence of infection is much higher than reported, but the infection rate is difficult to measure directly because of anicteric infection ..
  5. ncbi Changing risk profile of hepatitis A in The Netherlands: a comparison of seroprevalence in 1995-1996 and 2006-2007
    L Verhoef
    National Institute for Public Health and the Environment, Center for Infectious Disease Control, Laboratory for Infectious Diseases and Perinatal Screening, Bilthoven, The Netherlands
    Epidemiol Infect 139:1172-80. 2011
    The prevalence of antibodies to hepatitis A virus (HAV) was assessed in a nationwide sample (n=6229) in The Netherlands in 2006-2007, and compared to the seroprevalence in a similar study in 1995-1996 (n=7376)...
  6. ncbi Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals
    S Vento
    Infectious Diseases Unit, A Pugliese Hospital, Catanzaro, Italy
    Lancet 337:1183-7. 1991
    ..3 cases of subclinical acute hepatitis A occurred during the study...
  7. pmc Declining hepatitis A seroprevalence: a global review and analysis
    K H Jacobsen
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Epidemiol Infect 132:1005-22. 2004
    b>Hepatitis A virus (HAV) is spread by faecal-oral contact or ingestion of contaminated food or water...
  8. pmc Multilevel analysis of hepatitis A infection in children and adolescents: a household survey in the Northeast and Central-west regions of Brazil
    Ricardo Arraes de Alencar Ximenes
    State University of Pernambuco, School of Medical Sciences, Oswaldo Cruz University Hospital, Recife, PE, Brazil
    Int J Epidemiol 37:852-61. 2008
    The objectives were to estimate the prevalence of hepatitis A among children and adolescents from the Northeast and Midwest regions and the Federal District of Brazil and to identify individual-, household- and area-levels factors ..
  9. ncbi Hepatitis A virus seroprevalence by age and world region, 1990 and 2005
    Kathryn H Jacobsen
    Department of Global and Community Health, George Mason University, 4400 University Drive MS 5B7, Fairfax, VA 22030, USA
    Vaccine 28:6653-7. 2010
    To estimate current age-specific rates of immunity to hepatitis A virus (HAV) in world regions by conducting a systematic review and meta-analysis of published data...
  10. pmc Epidemiology and genetic characterization of hepatitis A virus genotype IIA
    Delphine Desbois
    centre national de Référence pour les virus des hépatites à transmission entérique, AP HP, Hopital Paul Brousse, Villejuif 94804, France
    J Clin Microbiol 48:3306-15. 2010
    Three hepatitis A virus (HAV) genotypes, I, II, and III, divided into subtypes A and B, infect humans. Genotype I is the most frequently reported, while genotype II is hardly ever isolated, and its genetic diversity is unknown...
  11. pmc Analysis of synonymous codon usage in hepatitis A virus
    Yiqiang Zhang
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China
    Virol J 8:174. 2011
    b>Hepatitis A virus is the causative agent of type A viral hepatitis, which causes occasional acute hepatitis. Nevertheless, little information about synonymous codon usage pattern of HAV genome in the process of its evolution is available...
  12. pmc Pattern of hepatitis a incidence according to area characteristics using national health insurance data
    Joo Youn Seo
    Department of Preventive Medicine Institute of Community Health, Hanyang University College of Medicine, Seoul, Korea
    J Prev Med Public Health 45:164-73. 2012
    Over the past several years, the incidence of hepatitis A infection has been increasing rapidly in the young-adult population in Korea...
  13. pmc Genome variability and capsid structural constraints of hepatitis a virus
    Gloria Sanchez
    Grup Virus Entèrics, Department of Microbiology, University of Barcelona, Spain
    J Virol 77:452-9. 2003
    ..mutations per nonsynonymous site (K(a)), and the codon usage statistic (N(c)) were calculated for several hepatitis A virus (HAV) isolates...
  14. ncbi Hepatitis a molecular epidemiology in the United States, 1996-1997: sources of infection and implications of vaccination policy
    Omana V Nainan
    Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA
    J Infect Dis 191:957-63. 2005
    The genetic relatedness of hepatitis A virus (HAV) isolates was determined to identify possible infection sources for case patients in the Sentinel Counties Study of Acute Viral Hepatitis.
  15. ncbi Cost-effectiveness analysis of universal childhood hepatitis A vaccination in Brazil: regional analyses according to the endemic context
    Ana Marli C Sartori
    Clínica de Moléstias Infecciosas do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil
    Vaccine 30:7489-97. 2012
    To conduct a cost-effectiveness analysis of a universal childhood hepatitis A vaccination program in Brazil.
  16. ncbi Monitoring the hepatitis A virus in urban wastewater from Rio de Janeiro, Brazil
    Tatiana Prado
    Laboratory of Technological Development in Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro RJ, Brazil
    Trans R Soc Trop Med Hyg 106:104-9. 2012
    b>Hepatitis A is a viral disease with a significant public health impact, especially in developing countries...
  17. ncbi Public awareness and practical knowledge regarding Hepatitis A, B, and C: a two-country survey
    Rik Crutzen
    Caphri, Maastricht University, The Netherlands
    J Infect Public Health 5:195-8. 2012
    To assess the level of public awareness and practical knowledge regarding Hepatitis A, B, and C in two low-endemic countries (Germany and The Netherlands).
  18. ncbi Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    George Ostapowicz
    Department of Medicine, Gold Coast Hospital, 108 Nerang Street, Southport, QLD 4215, Australia
    Ann Intern Med 137:947-54. 2002
    ..Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition...
  19. ncbi Epidemiological transition of hepatitis A in India: issues for vaccination in developing countries
    P Mathur
    Indian Council of Medical Research, New Delhi, India
    Indian J Med Res 128:699-704. 2008
    With improvement in economic and living conditions of the communities, the age of acquiring hepatitis A virus (HAV) infection is shifting from early childhood to adolescence and young adulthood...
  20. ncbi Methodology of a nationwide cross-sectional survey of prevalence and epidemiological patterns of hepatitis A, B and C infection in Brazil
    Ricardo Arraes de Alencar Ximenes
    Faculdade de Ciencias Medicas de Pernambuco, Universidade de Pernambuco, Recife, Brasil
    Cad Saude Publica 26:1693-704. 2010
    ..This paper describes the design and methodology of the study which involved a population aged 5 to 19 for hepatitis A and 10 to 69 for hepatitis B and C. Interviews and blood samples were obtained through household visits...
  21. ncbi Risk groups for hepatitis A virus infection
    Elisabetta Franco
    Department of Public Health, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy
    Vaccine 21:2224-33. 2003
    We report the conduct and results of a systematic search for evidence of risk of infection with hepatitis A virus (HAV) among blood transfusion recipients, travellers, the military, healthcare workers, sewage workers, foodhandlers, day ..
  22. ncbi Immunogenicity and safety of a virosomal hepatitis A vaccine (Epaxal) in the elderly
    Valérie D'Acremont
    Medical Outpatient Clinic, University Hospital, Lausanne, Switzerland
    J Travel Med 13:78-83. 2006
    Protection against hepatitis A virus (HAV) in the elderly is becoming more important as more senior travelers visit areas of high HAV endemicity, and less have protective antibodies acquired after natural infection during childhood...
  23. ncbi Incidence trends of viral hepatitis A, B, and C seropositivity over eight years of surveillance in Saudi Arabia
    Ziad A Memish
    Department of Infection Prevention and Control, King Abdulaziz Medical City, PO Box 22490, Riyadh 11426, Saudi Arabia
    Int J Infect Dis 14:e115-20. 2010
    ....
  24. ncbi Hepatitis A in the era of vaccination
    Annemarie Wasley
    Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Rev 28:101-11. 2006
    The World Health Organization estimates an annual total of 1.5 million clinical cases of hepatitis A worldwide, but seroprevalence data indicate that tens of millions of hepatitis A virus infections occur each year...
  25. pmc Hepatitis A: old and new
    J A Cuthbert
    Department of Internal Medicine, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390 9151, USA
    Clin Microbiol Rev 14:38-58. 2001
    The hepatitis A virus (HAV), a picornavirus, is a common cause of hepatitis worldwide...
  26. ncbi Surveillance for acute viral hepatitis - United States, 2007
    Danni Daniels
    Division of Viral Hepatitis, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, CDC, Atlanta, GA 30333, USA
    MMWR Surveill Summ 58:1-27. 2009
    ..United States, acute viral hepatitis most frequently is caused by infection with any of three distinct viruses: hepatitis A virus (HAV), hepatitis B virus (HBV), or hepatitis C virus (HCV)...
  27. ncbi [Comparison of recent IgG anti-HAV prevalence between two hospitals in Seoul and Gyeonggi area]
    Tae Yeob Kim
    Department of Internal Medicine, Hanyang University, Guri, Korea
    Korean J Hepatol 13:363-9. 2007
    Recently, the incidence of acute hepatitis A has increased nationwide and is related to the low rate of IgG anti-HAV...
  28. pmc Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination
    S M Lemon
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7030
    J Virol 65:2056-65. 1991
    Variants of hepatitis A virus (pHM175 virus) recovered from persistently infected green monkey kidney (BS-C-1) cells induced a cytopathic effect during serial passage in BS-C-1 or fetal rhesus kidney (FRhK-4) cells...
  29. ncbi Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Marek Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 107:251-7. 2003
    ..data are available on the relation between exposure to Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), and hepatitis A virus (HAV), individually or as a total pathogen score, and human cardiovascular (CV) disease.
  30. ncbi Pathogenesis of hepatitis A in orally inoculated owl monkeys (Aotus trivirgatus)
    L V Asher
    Department of Experimental Pathology, Walter Reed Army Institute of Research, Washington, D C 20307 5100, USA
    J Med Virol 47:260-8. 1995
    The pathogenesis of hepatitis A virus (HAV) infection was studied in owl monkeys following oral administration of the wild-type HM-175 strain of HAV...
  31. ncbi Hepatitis A outbreak activity in the United States: responding to a vaccine-preventable disease
    Allen S Craig
    Tennessee Department of Health, Nashville, Tennessee 37247, USA
    Am J Med Sci 334:180-3. 2007
    The occurrence of hepatitis A in the United States is heterogeneous because of disease cycles with substantial variation in incidence among states and involvement of numerous behavioral risk factors...
  32. ncbi [Recent etiology and clinical features of acute viral hepatitis in a single center of Korea]
    Hyung Min Kang
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Korean J Hepatol 13:495-502. 2007
    ..The aim of this study was to investigate the recent etiology and the clinical features of acute viral hepatitis in a single center of Korea...
  33. ncbi Genetic variability of hepatitis A virus in South America reveals heterogeneity and co-circulation during epidemic outbreaks
    M Costa-Mattioli
    Laboratorie de Virologie, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, Rue Quai Moncousu 9, 44093 Nantes, France
    J Gen Virol 82:2647-52. 2001
    Genetic analysis of selected genome regions of hepatitis A virus (HAV) suggested that distinct genotypes of HAV could be found in different geographical regions...
  34. ncbi Seroepidemiological markers of enterically transmitted viral hepatitis A and E in individuals living in a community located in the North Area of Rio de Janeiro, RJ, Brazil
    Damião Carlos Moraes dos Santos
    Departamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, 21045 900, Brasil
    Mem Inst Oswaldo Cruz 97:637-40. 2002
    We investigated the seroprevalence of hepatitis A virus (HAV) and hepatitis E virus (HEV) infection in subjects living in the community of Manguinhos, Rio de Janeiro, Brazil, and assisted at the Health Unit of Escola Nacional de Saúde P..
  35. ncbi A dynamic model for assessing universal Hepatitis A vaccination in Canada
    C T Bauch
    Department of Mathematics and Statistics, University of Guelph, Canada
    Vaccine 25:1719-26. 2007
    Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden...
  36. ncbi The intensity of transmission of hepatitis A and heterogeneities in socio-environmental risk factors in Rio de Janeiro, Brazil
    Liz Maria de Almeida
    Núcleo de Estudos de Saúde Coletiva, Universidade Federal do Rio de Janeiro, Av Brig Trompowski, S N, HUCFF, 5o andar Ala Sul, sala 25, Ilha do Fundao, 21941 590 Rio de Janeiro, RJ, Brazil
    Trans R Soc Trop Med Hyg 96:605-10. 2002
    The objective of this work was to assess the intensity of transmission of hepatitis A in Rio de Janeiro, Brazil. We also used the estimation of the parameters of a deterministic model to study the effects of risk factors...
  37. ncbi [Hepatitis A and hepatitis B seroprevalence in 4 centers in Brazil]
    S A Clemens
    Instituto de Pós Graduação Médica Carlos Chagas, Brasil
    Rev Soc Bras Med Trop 33:1-10. 2000
    The prevalence of antibodies to hepatitis A and B virus was assessed in 3,653 subjects across four regions of Brazil. The anti-HAV and anti-HBc seroprevalence were 64.7% and 7.9%, respectively. The highest anti-HAV (92...
  38. ncbi Person-to-person transmission of hepatitis A virus in an urban area of intermediate endemicity: implications for vaccination strategies
    J C Victor
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Am J Epidemiol 163:204-10. 2006
    Developing countries with an increasing hepatitis A disease burden may target vaccination to specific groups, such as young children, as an initial control strategy...
  39. ncbi Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis
    K Fujiwara
    First Department of Internal Medicine, Chiba University School of Medicine, Japan
    J Hepatol 35:112-9. 2001
    ..To examine whether genomic differences of hepatitis A virus (HAV) are responsible for the severity of the disease, we analyzed the whole HAV genomes from patients ..
  40. ncbi Evidence for quasispecies distributions in the human hepatitis A virus genome
    Gloria Sanchez
    Grup Virus Entèrics, Department of Microbiology, University of Barcelona, 08028 Barcelona, Spain
    Virology 315:34-42. 2003
    Nucleotide sequence analysis of multiple molecular clones of the hepatitis A virus (HAV), generated by reverse transcription-PCR of two capsid-coding regions, revealed a degree of heterogeneity compatible with a quasispecies structure in ..
  41. ncbi Inactivated hepatitis A vaccine booster given >/=24 months after the primary dose
    P Landry
    Travel Clinic, University Medical Policlinic, Rue César Roux 19, 1005, Lausanne, Switzerland
    Vaccine 19:399-402. 2000
    ..We investigated what happens with the immune response when people come back for their booster dose of inactivated hepatitis A vaccine later than the recommended time of 6-12 months after the primary dose...
  42. ncbi A mathematical model of hepatitis a transmission in the United States indicates value of universal childhood immunization
    Thierry P Van Effelterre
    GlaxoSmithKline Biologicals, Rixensart, B 1330, Belgium
    Clin Infect Dis 43:158-64. 2006
    US recommendations issued in 1999 for hepatitis A (HA) childhood immunization varied according to regional HA incidences prior to vaccination...
  43. ncbi Hepatitis A vaccination of infants: effect of maternal antibody status on antibody persistence and response to a booster dose
    Anthony E Fiore
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Mailstop G37, 1600 Clifton Road, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 22:354-9. 2003
    Infants with passively transferred maternal antibody (PMA) to hepatitis A virus (HAV) have lower concentrations of antibody to HAV (anti-HAV) after vaccination. We examined the effect of PMA on persistence of anti-HAV and on immune memory.
  44. ncbi Co-circulation of genotypes IA and IB of hepatitis A virus in Northeast Brazil
    L M Villar
    Departamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil
    Braz J Med Biol Res 39:873-81. 2006
    The Northeast region is the location of most cases of acute hepatitis A virus (HAV) in Brazil...
  45. ncbi Seroprevalence survey of varicella, measles, rubella, and hepatitis A and B viruses in a multinational healthcare workforce in Saudi Arabia
    M A Almuneef
    Department of Infection Prevention and Control, National Guard Health Affairs, King Abdulaziz Medical City King Fahad National Guard Hospital, Riyadh, Saudi Arabia
    Infect Control Hosp Epidemiol 27:1178-83. 2006
    To determine the prevalence of the vaccine-preventable diseases caused by varicella, measles, rubella, and hepatitis A and B viruses in a multinational healthcare workforce.
  46. ncbi Changing epidemiology of hepatitis A in Brazil: reassessing immunization policy
    C L Vitral
    Departamento de Microbiologia e Parasitologia, Instituto Biomedico, UFF, Niteroi, RJ, Rio de Janeiro, Brazil
    J Viral Hepat 15:22-5. 2008
    Recent studies have shown that the prevalence of antibody to hepatitis A virus (HAV) is decreasing in several Latin American countries. Brazil is a very large and heterogeneous country, showing striking regional differences...
  47. ncbi Recombination in hepatitis A virus: evidence for reproductive isolation of genotypes
    Ilya S Belalov
    M P Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia
    J Gen Virol 92:860-72. 2011
    This study analysed phylogenetic evidence of recombination in sequences of hepatitis A virus (HAV) available in international databases...
  48. ncbi Seroepidemiology of hepatitis A and hepatitis E viruses in Aden, Yemen
    Amen Ahmed Bawazir
    Medical Faculty, Aden University, P O Box 6336, Khormaksar, Aden, Yemen
    Trans R Soc Trop Med Hyg 104:801-5. 2010
    The burden of hepatitis A (HAV) and hepatitis E (HEV) infection is unknown in Aden, Yemen. This survey describes the prevalence of antibodies against HAV and HEV among individuals attending primary health care facilities in Aden, Yemen...
  49. ncbi Comparative analysis of disease severity between genotypes IA and IIIA of hepatitis A virus
    Young Kyung Yoon
    Division of Infectious Diseases, Korea University College of Medicine, Seoul, Korea
    J Med Virol 83:1308-14. 2011
    Although hepatitis A is a major health problem worldwide, it has not yet been clarified whether or not viral factors affect the clinical characteristics...
  50. ncbi [Epidemiology and clinical features of acute hepatitis A: from the domestic perspective]
    Young Kul Jung
    Department of Internal Medicine, Gachon University of Medicine and Science, Inchon, Korea
    Korean J Hepatol 15:438-45. 2009
    Acute viral hepatitis A has recently become a major public health problem in Korea, and the incidence of symptomatic hepatitis A is growing rapidly...
  51. ncbi Hepatitis A virus genetic diversity in Venezuela: exclusive circulation of subgenotype IA and evidence of quasispecies distribution in the isolates
    Y Sulbaran
    Laboratorio de Virologia Molecular, CMBC, IVIC, Caracas, Venezuela
    J Med Virol 82:1829-34. 2010
    b>Hepatitis A virus (HAV) infection is highly prevalent in Latin America, including Venezuela. Subgenotype IA seems to circulate in an almost exclusive fashion, except in Brazil...
  52. ncbi Prevalence of hepatitis A, B and C serological markers in children from western Mexico
    Griselda Escobedo-Meléndez
    Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara Fray Antonio Alcalde and University of Guadalajara, Guadalajara, Jalisco, Mexico
    Ann Hepatol 11:194-201. 2012
    ..Viral hepatitis in children is a major public health problem worldwide...
  53. pmc Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection
    Yan Zhou
    Center for Vaccines and Immunity, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    J Exp Med 209:1481-92. 2012
    b>Hepatitis A virus (HAV) infection typically resolves within 4-7 wk but symptomatic relapse occurs in up to 20% of cases...
  54. ncbi Use of molecular epidemiology to confirm a multistate outbreak of hepatitis A caused by consumption of oysters
    Stephanie R Bialek
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 44:838-40. 2007
    The 39 oyster consumption-related cases of hepatitis A reported in 2005 represent the first large outbreak of hepatitis A associated with shellfish consumption in the United States in >15 years...
  55. ncbi Ecology and prevention of a shellfish-associated hepatitis A epidemic in Shanghai, China
    Z Y Xu
    Department of Epidemiology, School of Public Health, Shanghai Medical University, People s Republic of China
    Vaccine 10:S67-8. 1992
    During a shellfish-borne hepatitis A outbreak in Shanghai during the first quarter of 1988, 300,000 cases were reported in two months...
  56. ncbi Prevalence of hepatitis A virus infection: the paradoxical example of isolated communities in the western Brazilian Amazon region
    Wornei Silva Miranda Braga
    Virology Unit, Tropical Medicine Foundation of Amazonas, Av Pedro Teixeira 25, Manaus, AM, Brazil
    Rev Soc Bras Med Trop 42:277-81. 2009
    This study evaluated the prevalence of hepatitis A virus infection in the rural area of Lábrea, in the western Brazilian Amazon region. Communities and households were selected randomly...
  57. pmc Seroprevalence of fecal-oral transmitted hepatitis A and E virus antibodies in Burkina Faso
    Kuan Abdoulaye Traoré
    Centre de Recherche en Sciences Biologique Alimentaire Nutritionnelles CRSBAN, Universite de Ouagadougou, Ouagadougou, Burkina Faso
    PLoS ONE 7:e48125. 2012
    b>Hepatitis A virus (HAV) and hepatitis E virus (HEV) infections occur chiefly as a result of unhygienic conditions...
  58. pmc Hepatitis A surveillance and vaccine use in China from 1990 through 2007
    Fuqiang Cui
    Chinese Center for Disease Control and Prevention, Beijing, China
    J Epidemiol 19:189-95. 2009
    b>Hepatitis A vaccines have been highly effective in preventing hepatitis A...
  59. ncbi Exposure to multiple subgenotypes of hepatitis A virus during an outbreak using matched serum and saliva specimens
    Luciane Almeida Amado
    Laboratory of Technological Development in Virology, Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro RJ, Brazil
    J Med Virol 83:768-75. 2011
    Matched serum and saliva samples were collected simultaneously from 124 subjects exposed during a hepatitis A virus (HAV) outbreak at a daycare center in Rio de Janeiro, Brazil...
  60. ncbi Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil
    Claudia Lamarca Vitral
    Departamento de Microbiologia e Parasitologia, Instituto Biomedico, Universidade Federal Fluminense, Niteroi, RJ, Brasil
    Mem Inst Oswaldo Cruz 107:652-8. 2012
    ..studies that have been conducted in Brazil have indicated a transition from a high to a medium endemicity of hepatitis A virus (HAV) infection in the population...
  61. pmc Nucleotide variability and translation efficiency of the 5' untranslated region of hepatitis A virus: update from clinical isolates associated with mild and severe hepatitis
    Vincent Mackiewicz
    AP HP, Hôpital Paul Brousse Centre National de Référence du Virus de l Hépatite A, Villejuif, France
    J Virol 84:10139-47. 2010
    Mutations in the internal ribosome entry site (IRES) of hepatitis A virus (HAV) have been associated with enhanced in vitro replication and viral attenuation in animal models...
  62. ncbi Prevalence of anti-HAV and anti-HEV antibodies in Konya, Turkey
    M Emre Atabek
    Department of Paediatrics, School of Medicine, Selcuk University, Konya 38039, Turkey
    Health Policy 67:265-9. 2004
    To determine the prevalence of antibodies to hepatitis A (HAV) and E (HEV) viruses in the different areas of Konya.
  63. pmc The increasing prominence of household transmission of hepatitis A in an area undergoing a shift in endemicity
    J C Victor
    Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, USA
    Epidemiol Infect 134:492-7. 2006
    In the rapidly developing city of Almaty, Kazakhstan, rates of hepatitis A have fallen, but no data on prevalence of antibody to hepatitis A virus (anti-HAV) exist with which to interpret incidence data...
  64. ncbi The association of hepatitis A and Helicobacter pylori with sensitization to common allergens, asthma and hay fever in a population of young British adults
    D Jarvis
    Department of Public Health Sciences, Kings College London Guys Campus, London, UK
    Allergy 59:1063-7. 2004
    ..A negative association of oro-faecally spread infection with serological markers of sensitization and allergic disease has been reported...
  65. ncbi Acute hepatitis A and B in patients with chronic liver disease: prevention through vaccination
    Emmet B Keeffe
    Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Am J Med 118:21S-27S. 2005
    Retrospective and prospective studies have demonstrated that the occurrence of acute hepatitis A in patients with chronic liver disease is associated with higher rates of morbidity and mortality than in previously healthy individuals ..
  66. ncbi Epidemiologic shift in the prevalence of Hepatitis A virus in Saudi Arabia: a case for routine Hepatitis A vaccination
    M A Almuneef
    Department of Infection Prevention and Control, King Abdulaziz Medical City King Fahad National Guard Hospital, Riyadh, Saudi Arabia
    Vaccine 24:5599-603. 2006
    This study aims to determine the seroprevalence of Hepatitis A among a selected group of Saudi children and thus, identify the best immunization strategy...
  67. ncbi Seroepidemiology of hepatitis A virus infection among schoolchildren in Taiwan
    Chin Feng Tsai
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    J Med Virol 83:196-200. 2011
    Taiwan was a hyperendemic area for hepatitis A virus (HAV) infection before 1980. The aim of this study was to examine the association between seropositivity of antibodies against HAV (anti-HAV) by a community-based survey...
  68. ncbi Hepatitis a in Lebanon: a changing epidemiological pattern
    Robert G Sacy
    St Georges Hospital, Beirut, Lebanon
    Am J Trop Med Hyg 73:453-6. 2005
    In this multicenter study in Lebanon, hepatitis A virus (HAV) seroprevalence rates were surveyed by age, gender, and socioeconomic factors. Blood samples collected from 606 subjects aged 1 to 30 years were analyzed for anti-HAV IgG...
  69. pmc Control of hepatitis A by universal vaccination of adolescents, Puglia, Italy
    Pietro Luigi Lopalco
    Emerg Infect Dis 14:526-8. 2008
  70. ncbi Age-specific prevalence of antibodies to hepatitis A in Santiago, Chile: risk factors and shift in age of infection among children and young adults
    Alan D Fix
    International Health Division, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Trop Med Hyg 66:628-32. 2002
    Transition from high to lower endemicity of hepatitis A virus (HAV) infection may portend increased public health burden with the shift of infection to older ages and increasing morbidity and mortality...
  71. ncbi Assessing potential introduction of universal or targeted hepatitis A vaccination in the Netherlands
    A W M Suijkerbuijk
    Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 30:5199-205. 2012
    In many industrialized countries, hepatitis A incidence rates have declined steadily in the past decades...
  72. ncbi Prevalence of hepatitis A virus infection among sewage workers in Georgia
    Linda Venczel
    Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Ind Med 43:172-8. 2003
    Wastewater (WW) workers could have opportunity for direct contact with raw sewage, which might contain hepatitis A virus (HAV).
  73. ncbi Hepatitis A seroprevalence in children and young adults in Istanbul, Turkey: seroprevalence change and associated factors
    N Ceran
    Haydarpasa Numune Training and Research Hospital, Infectious Diseases and Clinical Microbiology Department, Istanbul, Turkey
    J Viral Hepat 19:72-6. 2012
    b>Hepatitis A is a widespread infectious disease. The prevalence of the disease is closely related to socioeconomic status (SES) and environmental factors. Understanding its prevalence is essential for instituting appropriate precautions...
  74. ncbi Acute hepatitis A in Italy: incidence, risk factors and preventive measures
    M E Tosti
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome, Italy
    J Viral Hepat 15:26-32. 2008
    The incidence of, and risk factors for, acute hepatitis A (AHA) were assessed by using data collected from the Italian surveillance system of acute viral hepatitis (SEIEVA)...
  75. pmc A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates
    Donghun Lee
    Department of Internal Medicine, Seoul Saeroun Internal Medicine, Seoul, Korea
    Korean J Hepatol 17:44-50. 2011
    Recent outbreak of hepatitis A in Korea is clearly related to the epidemiological shift of hepatitis A virus (HAV). However, nationwide seroprevalence data have been limited...
  76. ncbi A unique HAV strain circulated in patients with acute HAV infection with different risk exposures in Tuscany, Italy
    Stefania Taffon
    Istituto Superiore di Sanita, Department of Infectious, Parasitic and Immune Mediated Disease, Rome, Italy
    J Clin Virol 50:142-7. 2011
    Acute Hepatitis A Virus (HAV) is reported to be an emergent problem in several developed countries.
  77. ncbi Hepatitis A seroprevalence and demographics in Turkish children in Ankara
    Rukiye U Sac
    Department of Pediatrics, Ankara Training and Research Hospital, Ankara, Turkey
    Pediatr Int 51:5-8. 2009
    b>Hepatitis A virus (HAV) is the most common cause of hepatitis in childhood and an important public health problem...
  78. ncbi Changing epidemiology of hepatitis A infection in Izmir, Turkey
    Zafer Kurugol
    Ege University, Medical Faculty, Department of Pediatrics, 35100 Izmir, Turkey
    Vaccine 29:6259-61. 2011
    The seroprevalence study was conducted in order to determine the current seroepidemiology hepatitis A in Izmir, Turkey and to evaluate the epidemiological shift in HAV serostatus...
  79. ncbi Hepatitis A vaccines
    Hans Dieter Nothdurft
    Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany, Leopoldstrasse 5, D 80802 Munich, Germany
    Expert Rev Vaccines 7:535-45. 2008
    The global disease burden associated with hepatitis A virus (HAV) is expected to increase in the coming years due to a shift in the epidemiological pattern of the disease...
  80. ncbi Age-specific seroprevalence of hepatitis A infection among children visited in pediatric hospitals of Tehran, Iran
    Ali Jafari Mehr
    Research Center for Gastroenterology and Liver Disease, Taleghani Hospital, Tehran, Iran
    Eur J Epidemiol 19:275-8. 2004
    b>Hepatitis A is an enterically transmitted disease that still remains endemic in many developing countries...
  81. ncbi Response to hepatitis A vaccine in HIV-positive patients
    S Weissman
    Infectious Disease Section, Department of Medicine, Hospital of Saint Raphael, New Haven, CT, USA
    J Viral Hepat 13:81-6. 2006
    ..with human immunodeficiency virus (HIV) recommends that all susceptible HIV+ patients at increased risk for hepatitis A virus (HAV) or with chronic liver disease, be vaccinated against HAV...
  82. ncbi A comparison of hepatitis A and hepatitis B measures among vaccinated and susceptible online men who have sex with men
    L K Gilbert
    American Social Health Association, Research Triangle Park, NC 27709, USA
    Int J STD AIDS 21:400-5. 2010
    b>Hepatitis A virus (HAV) and hepatitis B virus (HBV) continue to be major health concerns among men who have sex with men (MSM)...
  83. ncbi Prevalence of hepatitis A IgG in individuals with chronic hepatitis B infection in Babol
    M R H Roushan
    Department of Infectious Diseases, Yahyanejad Hospital, Islamic Republic of Iran
    East Mediterr Health J 13:1108-13. 2007
    To determine the prevalence of previous hepatitis A virus (HAV) infection in people chronically infected with hepatitis B virus (HBV), we assessed the prevalence of anti-HAV IgG in 392 patients...
  84. ncbi Hepatitis A: disease burden and current childhood vaccination strategies in the United States
    Mary Beth Koslap-Petraco
    Suffolk County Department of Health Services, Hauppauge, NY 11788, USA
    J Pediatr Health Care 22:3-11. 2008
    b>Hepatitis A can be a serious disease and represents a substantial health and economic burden...
  85. pmc Community-based cross-sectional seroprevalence study of hepatitis A in Bangladesh
    Samir K Saha
    Bangladesh Institute of Child Health, Dhaka Shishu Hospital, Dhaka 1207, Bangladesh
    World J Gastroenterol 15:4932-7. 2009
    To elucidate the age-distribution of anti-hepatitis A virus (HAV) seroprevalence across different socioeconomic status (SES) categories in Bangladesh which, despite scarce data, is generally deemed to have high endemicity.
  86. pmc Emerging need for vaccination against hepatitis A virus in patients with chronic liver disease in Korea
    Hyun Joo Song
    Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University College of Medicine, Seoul, Korea
    J Korean Med Sci 22:218-22. 2007
    Vaccination against hepatitis A virus (HAV) is recommended for patients with chronic liver disease (CLD), but this has been deemed unnecessary in Korea since the immunity against HAV was almost universal in adults...
  87. ncbi [The age-specific seroprevalence of hepatitis A virus antibody in Korea]
    Young Bong Song
    Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Hepatol 13:27-33. 2007
    The epidemiology of hepatitis A is associated with socioeconomic and hygiene status. Recently, the prevalence of hepatitis A in young adults has been steadily increasing in Korea...
  88. ncbi [Changes in the seroprevalence of hepatitis A virus antibody in Korea]
    Jae Hong Park
    Korean J Hepatol 13:1-4. 2007
  89. ncbi Molecular epidemiological studies show that hepatitis A virus is endemic among active homosexual men in Europe
    Kathrine Stene-Johansen
    Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
    J Med Virol 79:356-65. 2007
    Large outbreaks of hepatitis A have occurred in Denmark, Germany, the Netherlands, Norway, Spain, Sweden, and the United Kingdom during the period 1997-2005 affecting homosexual men...
  90. pmc Epidemiology of hepatitis A virus infections, Germany, 2007-2008
    Mirko S Faber
    Robert Koch Institute, Berlin 13086, Germany
    Emerg Infect Dis 15:1760-8. 2009
    Approximately 60% of hepatitis A virus infections in Germany occur in persons without a travel history to disease-endemic areas and for whom sources of infection are unknown...
  91. ncbi Increasing incidence of hepatitis A in Korean adults
    Yoon Jun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Intervirology 53:10-4. 2010
    b>Hepatitis A infection is caused by the hepatitis A virus (HAV), which is transmitted through the fecal-oral route. Lifelong protective antibodies are present after infection...
  92. ncbi Seroprevalence and risk factors of hepatitis A virus infection in Iran: a population based study
    Shahin Merat
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, N Kargar Street, Tehran, Iran
    Arch Iran Med 13:99-104. 2010
    In older studies, the seroprevalence of hepatitis A virus infection has been reported to be over 95% in Iranians. Most of these studies were performed on volunteer blood donors. Studies on the general population are sparse...
  93. ncbi Seroepidemiology of hepatitis A virus in children of different age groups in Tehran, Iran: implications for health policy
    Masoomeh Sofian
    Arak University of Medical Sciences, Arak, Iran
    Travel Med Infect Dis 8:176-9. 2010
    b>Hepatitis A is one of the most frequently reported vaccine-preventable diseases throughout the world and remains endemic in many areas. Studies in various communities have shown that Hepatitis A virus (HAV) prevalence rises with age...
  94. ncbi Hepatitis A and travel amongst Nova Scotia postsecondary students: evidence for a targeted vs. universal immunization strategy
    Katherine Matheson
    Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Vaccine 28:8105-11. 2010
    Canadian guidelines recommend hepatitis A virus (HAV) vaccination for high-risk persons, such as travelers to HAV-endemic areas. The US CDC advocates universal immunization.
  95. pmc Seroepidemiology of hepatitis A and hepatitis B virus in Luxembourg
    J Mossong
    Laboratoire National de Santé, LuxembourgCRP Santé, Luxembourg
    Epidemiol Infect 134:808-13. 2006
    ..carried out in Luxembourg in 2000-2001 to determine the antibody status of the Luxembourg population against hepatitis A virus (HAV) and hepatitis B virus (HBV)...
  96. ncbi The evolving epidemiology of hepatitis a in the United States: incidence and molecular epidemiology from population-based surveillance, 2005-2007
    R Monina Klevens
    Division of Viral Hepatitis, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 37, Atlanta, Georgia 30333, USA
    Arch Intern Med 170:1811-8. 2010
    The incidence of hepatitis A virus (HAV) disease is the lowest ever in the United States...
  97. ncbi A review of the long-term protection after hepatitis A and B vaccination
    Pierre Van Damme
    Centre for the Evaluation of Vaccination, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, Department of Epidemiology and Social Medicine, University of Antwerp, Belgium
    Travel Med Infect Dis 5:79-84. 2007
    ..4 million cases of hepatitis A are reported every year. The true incidence, however, has been estimated to be 3-10 times higher...
  98. pmc Hepatitis A and B superimposed on chronic liver disease: vaccine-preventable diseases
    Emmet B Keeffe
    Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Trans Am Clin Climatol Assoc 117:227-37; discussion 237-8. 2006
    A number of studies have demonstrated that the acquisition of hepatitis A or hepatitis B in patients with chronic liver disease is associated with high rates of morbidity and mortality...
  99. ncbi Decline in the risk of hepatitis A virus infection in China, a country with booming economy and changing lifestyles
    Zhi Yu Xu
    International Vaccine Institute, Seoul, Korea
    J Viral Hepat 15:33-7. 2008
    The objective of the study was to identify the protective factors for the rapid decline in the risk of hepatitis A virus (HAV) infection in China between 1990 and 2006...
  100. ncbi Duration of viremia in human hepatitis A viral infection as determined by polymerase chain reaction
    H Yotsuyanagi
    First Department of Internal Medicine, University of Tokyo, Japan
    J Med Virol 40:35-8. 1993
    Viremia in hepatitis A viral (HAV) infection is said to be limited to pre-symptomatic period. However, it is not clear how long viremia lasts in human infection due to the lack of a simple and sensitive detection system...
  101. ncbi Hepatitis A impairs the function of human hepatic CYP2A6 in vivo
    M Pasanen
    Department of Pharmacology and Toxicology, University of Oulu, Finland
    Toxicology 123:177-84. 1997
    ..Such metabolic responses may be of clinical importance and may also interfere with other drug therapy in these patients...

Research Grants62

  1. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    Project Summary Prior to implementing universal childhood vaccination in Alaska, rates of hepatitis A in Alaska Native persons were more than five times higher than those in other racial/ethnic populations...
  2. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..In addition, there is increasing risk of disease transmission from current blood supplies including HIV, Hepatitis A virus, B19 parvovirus, Hepatitis C virus, and infectious prion proteins the agents associated with variant ..
  3. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2011
    ..to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV)...
  4. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..continue to be essential models in the development of vaccines for hepatitis B virus, hepatitis C virus, hepatitis A virus, respiratory syncytial virus, and human immunodeficiency virus and play a critical role in the evaluation ..
  5. NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE
    BRIAN JAMES MCMAHON; Fiscal Year: 2012
    Infections from hepatitis A virus (HAV) and hepatitis B virus (HBV) are significant problems in Alaska Natives. Hepatitis A and B vaccines have been routine immunizations in Alaska Natives since 1984 and 1994, respectively...
  6. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..Cyclospora cayatanensis, Entamoeba histolytica, Giardia lamblia and Microsporidia) and viruses (Caliciviruses, Hepatitis A virus and Rotavirus) respectively...
  7. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..in inactivating enveloped viruses, such as HIV, but are not very effective against nonenveloped viruses such as Hepatitis A (HAV) and parvovirus B19...
  8. Immunotoxicity in Humans with Lifetime Exposure to Ocean Pullutants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2013
    ..response in adults aged 28 to a booster dose (diphtheria and tetanus) and to vaccination with new antigens (hepatitis A and B)...
  9. Validity of Self-Reported Adult Vaccination Status
    SHARON L ROLNICK; Fiscal Year: 2010
    ..Many of the vaccinations, such as tetanus/diphtheria, pneumococcal polysaccharide vaccine, and the hepatitis A and hepatitis B series, may have been administered 10-15 years before the survey is answered, thereby ..
  10. 3C Protease Polyubiquitylation as a Picornavirus Replication Success Determinant
    THOMAS GLEN LAWSON; Fiscal Year: 2012
    ..Like all picornaviruses, the encephalomyocarditis virus (EMCV) and hepatitis A virus (HAV) produce a protein called the 3C protease, which is absolutely required for virus replication in ..
  11. Membrane Hijacking: Biogenesis and Fate of Enveloped Hepatovirus
    Stanley M Lemon; Fiscal Year: 2013
    ..diverse family of positive-strand RNA viruses that include a number of important human pathogens, among them hepatitis A virus (HAV), an hepatotropic virus that is the causative agent of acute hepatitis A and the only species in the ..
  12. A New Point of Use Decontamination Method for Fresh Produce
    ADRIAN J DENVIR; Fiscal Year: 2010
    ..coli O157:H7, Salmonella species, Listeria monocytogenes, Shigella species, Cyclospora cayetanensis, Hepatitis A virus, and Norwalk-like virus...
  13. Electron microscopy studies of novel poliovirus genome-releasing intermediates
    Hazel C Levy; Fiscal Year: 2010
    ..HEALTH RELEVANCE: The Picornavirus family includes cardioviruses, foot-and-mouth disease virus, rhinoviruses, hepatitis A virus and enteroviruses. Among these, there are significant causes of human and veterinary diseases...
  14. Connecticut Emerging Infections Program
    MATTHEW LEWIS CARTTER; Fiscal Year: 2011
    ..conducts an integrated hepatitis surveillance project that includes surveillance and prevention activities for hepatitis A, B, and C;a population-based surveillance for newly diagnosed and pre-existing cases of chronic liver disease ..
  15. Functional role of a host metabolic enzyme in viral replication
    Peter Nagy; Fiscal Year: 2010
    ..Accordingly, GAPDH has been shown to bind to AU-rich sequences present in various RNA viruses, including hepatitis A virus (HAV), hepatitis C virus, and human parainfluenza virus type 3...
  16. Prevention of the Complications of Bleeding Disorders Through Hemo Tmt Centers
    CHRISTINE KEMPTON; Fiscal Year: 2010
    ..Other specific project objectives include: (1) provide continuous screening for HIV and Hepatitis A, B, and C;(2) facilitate improved regional information management systems, data collection and evaluation;(3) ..
  17. Assembly of Picornaviral Replication Complexes
    Olve Peersen; Fiscal Year: 2009
    ..Members include acute hepatitis A virus, the heart disease causing coxsackie B3 virus, rhinoviruses that cause more than half the occurrences of ..
  18. Subversion of Autophagy Pathway and Constituents by RNA viruses
    Karla Kirkegaard; Fiscal Year: 2013
    ..These principles are also applied to the study of hepatitis A virus, a picornavirus whose ability to spread through the liver with no apparent cell lysis remains mysterious ..
  19. Assembly of Picornaviral Replication Complexes
    OLVE BREIEN PEERSEN; Fiscal Year: 2013
    ..Members include acute hepatitis A virus, the heart disease causing coxsackie B3 virus, rhinoviruses that cause more than half the occurrences of ..
  20. CENTER FOR VULNERABLE POPULATIONS RESEARCH
    Deborah Koniak Griffin; Fiscal Year: 2009
    ..g., HIV/AIDS, hepatitis A/B/C, tuberculosis), chronic illness (cardiovascular disease, diabetes, asthma) substance use, and environmental ..
  21. The Role of Proteasomes in Viral RNA Translation
    Evgeny V Pilipenko; Fiscal Year: 2010
    ..mRNA translation is mediated by an Internal Ribosome Entry Segment (IRES), such as Hepatitis C virus (HCV) and Hepatitis A virus (HAV)...
  22. A Multi-Center Group to Study Acute Liver Failure
    William M Lee; Fiscal Year: 2013
    ..APAP) in ALF in United States patients and further characterized many of the other etiologies such as hepatitis A, hepatitis B, autoimmune hepatitis and ischemic liver disease as well as focusing on disease outcomes and the ..
  23. Hepatitis Care Coordination in Methadone Treatment
    David C Perlman; Fiscal Year: 2010
    ..provided by applicant): Intravenous drug users have extremely high rates of viral hepatitis including hepatitis A (HAV), hepatitis B (HBV), and hepatitis C (HCV) and are the major vector of spread of HCV in the U.S...
  24. Hepatitis Care Coordination in Methadone Treatment
    Carmen L Masson; Fiscal Year: 2010
    ..provided by applicant): Intravenous drug users have extremely high rates of viral hepatitis including hepatitis A (HAV), hepatitis B (HBV), and hepatitis C (HCV) and are the major vector of spread of HCV in the U.S...
  25. Signaling and Cell Biology of TIM-1
    Lawrence P Kane; Fiscal Year: 2013
    ..The founding member of the family, TIM-1, was first described as a receptor for the hepatitis A virus (HAVcr-1)...
  26. Isothermal Titration Calorimeter
    Robert S Hodges; Fiscal Year: 2013
    ..of RNAs to cellular proteins and ribosomes to elucidate mechanisms of viral infection which cause hepatitis C, hepatitis A, polio, and HIV (Kieft, J.S...
  27. Positive Strand RNA Viruses
    David L Woodland; Fiscal Year: 2013
    ..including a large number of important human pathogens like hepatitis C virus, West Nile and dengue viruses, hepatitis A virus and poliovirus...
  28. An Antisense Design and Simulation Platform
    NORM EARL WATKINS; Fiscal Year: 2013
    ..literature for cancer, immune deficiency disorders, diabetes, muscular dystrophy and cardiovascular disease, hepatitis A and C, HIV, SARS-coronovirus, Ebola, Dengue Fever, paramyxoviruses (measles), and the West Nile virus...
  29. Manipulation of cellular translation machinery by viral RNAs
    Jeffrey S Kieft; Fiscal Year: 2013
    ..IRESs are central players in the infection cycles of many important viruses (e.g. hepatitis C, hepatitis A, poliovirus, HIV-1) and are significant regulators of gene expression...
  30. Stress management and vaccine response among women at risk for breast cancer
    Bonnie A McGregor; Fiscal Year: 2010
    ..Study outcomes will include antibody and cellular immune response to hepatitis A vaccine and self-reported distress...
  31. Yeast-Based High-throughput Assays for Proteases of Category A, B, & C Viruses
    Hong Fang; Fiscal Year: 2009
    ..produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and Norwalk Virus...
  32. STRUCTURAL STUDIES OF PROTEIN SUBUNITS
    Thomas Smith; Fiscal Year: 2004
    Picornaviruses are among the largest of animal virus families and include cardio-, polio-, rhino-, and hepatitis A viruses...
  33. HEPATITIS A AND GASTROENTERITIS VIRUSES IN MARINE LIFE
    Charles Gerba; Fiscal Year: 1980
    ..The methods will then be used in the field to determine the prevalence of HAV and the agents of viral gastroenteritis in sewage and shellfish. ..
  34. INFECTION AND CARDIOVASCULAR DISEASE
    Michael Davidson; Fiscal Year: 2001
    ..In addition, assays will be performed for antibodies to Helicobacter pylori, hepatitis A virus, (HAV) and herpes simplex virus (HSV) type 1 and 2...
  35. Determinants of RNA virus evolution
    ISABEL NOVELLA; Fiscal Year: 2009
    ..Some representatives of this large group of pathogens are hepatitis A, B and C viruses, HIV, influenza virus, most of the cold viruses, rabies virus, Ebola virus, West Nile virus, ..
  36. APLASTIC ANEMIA EPIDEMIOLOGY--INCIDENCE AND CASE CONTROL
    David Kaufman; Fiscal Year: 2000
    ..that poor sanitation increases the risk, suggested by associations with low socioeconomic status and hepatitis A; and a more detailed evaluation of occupation...
  37. STRUCTURE/FUNCTION RELATIONS IN HAV REPLICATION
    STANLEY LEMON; Fiscal Year: 2000
    ..studies are aimed at characterizing structure-function relationships within the 5 nontranslated RNA (5NTR) of hepatitis A virus (HAV)...
  38. BIODEGRADABLE MINERAL MICROSPHERE ADJUVANTS FOR VACCINES
    ELIE NUWAYSER; Fiscal Year: 1999
    ..vaccines, now recommended for a large population including all adolescents and all health workers, but also for hepatitis A vaccine and for many components of the childhood vaccination series...
  39. Innovative Single-Dose Hepatitis B Vaccine Formulation
    J Kitchell; Fiscal Year: 2002
    ..Their discovery led to a simple and elegant method of formulating alum-adjuvanted hepatitis A vaccine as a single-dose injection giving multiple delayed pulses...
  40. MOLECULAR PATHOGENESIS OF DIGESTIVE DISEASES
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..Infections under study include hepatitis A-D, polio virus, H. pylori, and diarrheal agents such as rotavirus, salmonella, E...
  41. Temperature-dependent, Intermediate Particles from the Entry of Picornaviruses in
    David Belnap; Fiscal Year: 2009
    ..Picornaviruses (e.g. common-cold viruses, poliovirus, and hepatitis A virus) are important human pathogens...
  42. A Randomized Trial of Vaccine Adherence in Young IDU
    Paula Lum; Fiscal Year: 2006
    ..We will follow this cohort of 300 individuals for one year, administering a combined hepatitis A virus (HAV) inactivated and hepatitis B virus (HBV) recombinant vaccine (Twinrix() to study medical management ..
  43. STRESS AND MENTAL HEALTH IN OLDER ADULTS
    Janice Kiecolt Glaser; Fiscal Year: 2001
    ..By assessing immune responses to hepatitis A and pneumococcal pneumonia vaccines (as well as continued studies on influenza vaccine), the study will provide ..
  44. A Rapid On-Site Human Fecal Contamination Biosensor
    JACK U REN; Fiscal Year: 2005
    ..a serious health hazard for the transmission of waterborne diseases such as typhoid fever, cholera, and hepatitis A. Therefore, sensitive measurements of water supplies and food handling processes for fecal microorganism are of ..
  45. THE IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE
    Antonio Chedid; Fiscal Year: 1991
    ....
  46. Pre-diagnostic markers of infection and risk of MS
    Alberto Ascherio; Fiscal Year: 2009
    ..now propose to expand our findings on EBV, to extend the investigation to human herpes virus 6 (HHV-6) and the hepatitis A virus, and to examine whether the presence of IgM antibodies to myelin oligodendrocyte glycoprotein (MOG) or ..
  47. A Prospective Study of Viral and Immune Correlates in Pediatric HIV-1 Infection
    Natascha Ching; Fiscal Year: 2009
    ..initiated a prospective evaluation of cellular and humoral immune responses to recall antigens (tetanus booster/Hepatitis A)...
  48. T cell diversity in the induction of autoimmunity
    Terri Laufer; Fiscal Year: 2006
    ..Understanding the requirements for T cell diversity and the interactions between "graft" T cells and host antigen presenting cells offers improved immunologic targets for preventing GVHD following bone marrow transplant. ..
  49. PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
    Thomas VanCott; Fiscal Year: 2000
    ..of specific antibody can protect against disease caused by viruses such as polio, measles, rubella, varicella, hepatitis A and hepatitis B...
  50. Genetics of Infection and its Relationship with CVD Risk
    Harald Goring; Fiscal Year: 2009
    ..7 common pathogens---Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, cytomegalovirus, hepatitis A virus, herpes simplex virus 1, and human herpesvirus 8---in a much larger pedigree sample of 2,500 Mexican ..
  51. SYNTHETIC HEPATITIS C ANTIGENS FOR SUBUNIT VACCINE
    ALAN WALFIELD; Fiscal Year: 1991
    ..A vaccine for hepatitis C would be the final application of this research proposal. Biologicals for the treatment of HCV infection may also be generated by this project...
  52. DEVELOPMENT OF A DETECTIVE HEPATITIS A VIRUS VACCINE
    Gary Van Nest; Fiscal Year: 1990
    ....
  53. Plasmacytoid dendritic cells, IFN-alpha, Th-1 response
    Frederick Siegal; Fiscal Year: 2004
    ..b>Hepatitis A vaccine, an FDA-approved immunogen that is well tolerated and often clinically indicated in humans will be the ..
  54. Single Well MPCR Donor Screen to ID Blood Pathogens
    Raymond Ranken; Fiscal Year: 2009
    ..West Nile and Dengue viruses), all influenza viruses (including human and avian), parvoviruses (including B19), hepatitis A virus, human herpes viruses (1-3, 5,8, excluding EBV), trypanosomes, and Plasmodium species...
  55. VIRAL INACTIVATION OF INTRAVENOUS IMMUNOGLOBULIN (IVIG)
    CLARK EDSON; Fiscal Year: 1999
    ..opportunity for treating plasma derivatives contaminated with pathogenic viruses like HIV, hepatitis C (HCV), hepatitis A (HAV) and parvovirus Bl9...
  56. Structural and biophysical analysis of a viral IRES
    JEFFREY KIEFT; Fiscal Year: 2009
    ..Viruses that use this mechanism include hepatitis C (HCV), hepatitis A (HAV), and foot and mouth disease (FMDV), among many others...
  57. Kim-1 in Renal Epithelial Cell Motility and Adhesion
    BENJAMIN HUMPHREYS; Fiscal Year: 2005
    ..It is proposed to be the cellular receptor for the hepatitis A virus and Kim-1 expression is upregulated in almost all renal cell carcinomas...
  58. RAPID ASSAY FOR HIV-1 ANTIBODIES IN SALIVA
    Thomas Thieme; Fiscal Year: 1992
    ..They propose clinical trials with their test for HIV-l antibodies and preclinical studies in development of tests for hepatitis A and hepatitis B.