kaposi sarcoma

Summary

Summary: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.

Top Publications

  1. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
  2. pmc KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
    Don Ganem
    Department of Medicine and Microbiology, University of California, 513 Parnassus Ave, San Francisco, CA 91413, USA
    J Clin Invest 120:939-49. 2010
  3. pmc Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    Xuezhong Cai
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:5570-5. 2005
  4. ncbi Trends in cancer risk among people with AIDS in the United States 1980-2002
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    AIDS 20:1645-54. 2006
  5. pmc Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
    Adam Grundhoff
    Howard Hughes Medical Institute and Department of Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    J Clin Invest 113:124-36. 2004
  6. pmc Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
    Minji Byun
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 207:2307-12. 2010
  7. ncbi Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy
    Gary M Clifford
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Natl Cancer Inst 97:425-32. 2005
  8. pmc Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research at University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 113:5938-41. 2009
  9. pmc Identification of cellular genes targeted by KSHV-encoded microRNAs
    Mark A Samols
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, United States of America
    PLoS Pathog 3:e65. 2007
  10. ncbi Kaposi sarcoma: a continuing conundrum
    Robert A Schwartz
    Department of Dermatology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Am Acad Dermatol 59:179-206; quiz 207-8. 2008

Detail Information

Publications309 found, 100 shown here

  1. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
    ..These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus...
  2. pmc KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
    Don Ganem
    Department of Medicine and Microbiology, University of California, 513 Parnassus Ave, San Francisco, CA 91413, USA
    J Clin Invest 120:939-49. 2010
    The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi sarcoma-associated herpesvirus [KSHV]) is one of the great successes of contemporary biomedical research and was achieved by using advanced genomic ..
  3. pmc Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    Xuezhong Cai
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:5570-5. 2005
    ..We hypothesize that these viral miRNAs play a critical role in the establishment and/or maintenance of KSHV latent infection in vivo and, hence, in KSHV-induced oncogenesis...
  4. ncbi Trends in cancer risk among people with AIDS in the United States 1980-2002
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    AIDS 20:1645-54. 2006
    ..People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality, but there are few large-scale studies on cancer trends...
  5. pmc Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
    Adam Grundhoff
    Howard Hughes Medical Institute and Department of Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    J Clin Invest 113:124-36. 2004
    b>Kaposi sarcoma-associated (KS-associated) herpesvirus (KSHV) infection is linked to the development of both KS and several lymphoproliferative diseases. In all cases, the resulting tumor cells predominantly display latent viral infection...
  6. pmc Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
    Minji Byun
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 207:2307-12. 2010
    Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basin, despite the high prevalence of human herpesvirus-8 (HHV-8) infection in this region...
  7. ncbi Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy
    Gary M Clifford
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Natl Cancer Inst 97:425-32. 2005
    ....
  8. pmc Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research at University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 113:5938-41. 2009
    ..miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS are associated with KS-associated herpesvirus infection...
  9. pmc Identification of cellular genes targeted by KSHV-encoded microRNAs
    Mark A Samols
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, United States of America
    PLoS Pathog 3:e65. 2007
    ..Recently, 12 miRNA genes have been identified within the genome of Kaposi sarcoma-associated herpesvirus; however, their functions are still unknown...
  10. ncbi Kaposi sarcoma: a continuing conundrum
    Robert A Schwartz
    Department of Dermatology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Am Acad Dermatol 59:179-206; quiz 207-8. 2008
    b>Kaposi sarcoma (KS) remains a challenge. Its classic or Mediterranean form tends to be benign. In transplant recipients it may be less so...
  11. pmc Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo
    Feng Qi An
    Department of Molecular Genetics and Microbiology, University of Florida, Shands Cancer Center, Gainesville, FL 32610 0232, USA
    J Virol 80:4833-46. 2006
    ..KSHV-infected LTCs represent the first xenograft model for KS and should be of use to study KS pathogenesis and for the validation of anti-KS drug candidates...
  12. ncbi Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
    C Boshoff
    Virology Laboratory, Royal Marsden Hospital, London, UK
    Nat Med 1:1274-8. 1995
    ..These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions...
  13. ncbi Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    J Clin Oncol 23:5224-8. 2005
    ..This clinical response, known as the immune reconstitution inflammatory syndrome (IRIS), occurs secondary to an immune response against previously diagnosed pathogens...
  14. ncbi Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease
    Vickie Marshall
    Viral Epidemiology Section, AIDS Vaccine Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, MD 21701, USA
    J Infect Dis 195:645-59. 2007
    MicroRNAs are small noncoding RNAs that posttranscriptionally regulate gene expression. Kaposi sarcoma (KS)-associated herpesvirus (KSHV) encodes 12 distinct microRNA genes, all of which are located within the latency-associated region ..
  15. ncbi Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells
    S A Keller
    Weill Graduate School of Medical Sciences of Cornell University, and the Departments of Medicine and Pathology of Weill Medical College of Cornell University, New York, NY, USA
    Blood 96:2537-42. 2000
    b>Kaposi sarcoma-associated herpesvirus (KSHV), or human herpervirus 8 (HHV-8), is a gamma-herpesvirus that infects human lymphocytes and is associated with primary effusion lymphoma (PEL)...
  16. ncbi A seroprevalence study of human herpesvirus type 8 (HHV8) in eastern and Central Africa and in the Mediterranean area
    D Serraino
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, IRCCS, Rome, Italy
    Eur J Epidemiol 17:871-6. 2001
    ..The high prevalence of HHV8 infection in newborns, children and adolescents in Egypt, in eastern and in Central Africa strongly suggests the existence of transmission modes other than sexual...
  17. ncbi Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa
    A Gessain
    Departement des Retrovirus, Institut Pasteur, Paris, France
    Int J Cancer 81:189-92. 1999
    ..We hypothesize that the lymphadenopathic form of KS seen in African children is related to an early and massive infection by HHV-8 in susceptible individuals...
  18. pmc A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing
    Eva Gottwein
    Department of Molecular Genetics and Microbiology, Box 3025, Duke University Medical Center, Durham, NC 27710, USA
    J Virol 80:5321-6. 2006
    ..This is the first report of a naturally occurring sequence polymorphism in an miRNA precursor that results in reduced processing and therefore lower levels of mature miRNA expression and function...
  19. ncbi The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium
    N S Haque
    Department of Medicine, Divisions of Hematology and Cardiology, and the Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 97:39-45. 2001
    ..for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in human cells by the Kaposi sarcoma-related human herpesvirus-8...
  20. ncbi Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy
    M Corbellino
    Institute of Infectious Diseases and Tropical Medicine, University of Milan, Italy
    Blood 98:3473-5. 2001
    b>Kaposi sarcoma-associated herpesvirus (KSHV)-related multicentric Castleman disease (MCD) is potentially lethal...
  21. ncbi Results of radiation therapy for treatment of classic Kaposi sarcoma
    David Hauerstock
    Department of Oncology, McGill University Health Centre, Montreal, QC
    J Cutan Med Surg 13:18-21. 2009
    Classic Kaposi sarcoma (CKS) is a vascular neoplasm that primarily affects men of Mediterranean and Ashkenazi Jewish descent...
  22. ncbi Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders
    Y Aoki
    Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 97:2173-6. 2001
    Expression of a viral interleukin-6 (vIL-6) has been detected in certain Kaposi sarcoma (KS)--associated herpesvirus positive (KSHV(+)) lesions...
  23. pmc Kaposi sarcoma incidence and survival among HIV-infected homosexual men after HIV seroconversion
    Sara Lodi
    Medical Research Council, Clinical Trials Unit, 222 Euston Rd, London NW1 2DA, UK
    J Natl Cancer Inst 102:784-92. 2010
    Despite the success of combination antiretroviral therapy (cART) in reducing the incidence of Kaposi sarcoma, HIV-infected individuals who have responded to treatment continue to be diagnosed with Kaposi sarcoma...
  24. pmc Kaposi sarcoma (KS)-associated herpesvirus microRNA sequence analysis and KS risk in a European AIDS-KS case control study
    Vickie Marshall
    Viral Oncology Section, SAIC Frederick, NCI Frederick, Frederick, Maryland 21702, USA
    J Infect Dis 202:1126-35. 2010
    We recently identified polymorphisms in Kaposi sarcoma-associated herpesvirus (KSHV)-encoded microRNA (miRNA) sequences from clinical subjects...
  25. pmc Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma
    M Dedicoat
    Liverpool School of Tropical Medicine, Hlabisa Hospital and the Africa Centre for Population Studies and Reproductive Health, PO Box 252, Hlabisa 3937, KwaZulu Natal, South Africa
    Br J Cancer 88:1-3. 2003
    ..These changes point to a role for other (as yet unknown) factors in the aetiology of Kaposi's sarcoma that may have the most effect in the absence of concurrent HIV infection...
  26. ncbi Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
    B Ensoli
    Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Nature 371:674-80. 1994
    ..The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present...
  27. pmc Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
    K A Staskus
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Virol 73:4181-7. 1999
    ..Our findings support the hypothesis that HHV-8 plays an important role in the pathogenesis of PEL and MCD, in which vIL-6 acts as an autocrine or paracrine factor in the lymphoproliferative processes common to both...
  28. pmc The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade
    Jeffrey S Scehnet
    Department of Pathology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Blood 113:254-63. 2009
    b>Kaposi sarcoma (KS) is associated with human herpesvirus (HHV)-8 and is dependent on the induction of vascular endothelial growth factors (VEGFs)...
  29. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
    ....
  30. ncbi Antibodies against human herpesvirus 8 in black South African patients with cancer
    F Sitas
    National Cancer Registry, Department of Anatomical Pathology, South African Institute for Medical Research, Johannesburg
    N Engl J Med 340:1863-71. 1999
    ....
  31. ncbi Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Semin Cancer Biol 18:423-36. 2008
    ..This review summarizes current knowledge of host immune evasion strategies of KSHV and their contributions to KSHV-associated diseases...
  32. ncbi Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR
    Carlos Bais
    Laboratory of Viral Oncogenesis, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Cell 3:131-43. 2003
    ..We conclude that vGPCR can cause an oncogenic immortalizing event and recapitulate aspects of the KS angiogenic phenotype in human endothelial cells, pointing to this gene as a pathogenic determinant of KSHV...
  33. pmc Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells
    Mandana Mansouri
    Vaccine and Gene Therapy Institute and Vollum Institute, Oregon Health and Science University, Portland, OR, USA
    Blood 108:1932-40. 2006
    The transmembrane ubiquitin ligase K5/MIR2 of Kaposi sarcoma herpesvirus (KSHV) mediates internalization and lysosomal degradation of glycoproteins involved in antigen presentation and co-stimulation...
  34. pmc Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases
    Li Wu Qian
    Tumor Virology Program, Greehey Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 81:7001-10. 2007
    ..Together, these results suggest that KSHV infection modulates the production of multiple MMPs to increase cell invasiveness and thus contributes to the pathogenesis of KSHV-induced malignancies...
  35. ncbi Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus
    Subhash C Verma
    Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    FEMS Microbiol Lett 222:155-63. 2003
    b>Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is the most recently discovered human oncogenic herpesvirus...
  36. pmc Comparison of serologic assays and PCR for diagnosis of human herpesvirus 8 infection
    T J Spira
    Immunology Branch, Division of AIDS, STD, and TB Laboratory Research, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 38:2174-80. 2000
    ..As described above, only a titer of >/=1:40 would be considered HHV-8 positive...
  37. pmc Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription
    Fang Lu
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    J Virol 80:5273-82. 2006
    ..These findings support the role of LANA as a transcriptional repressor of lytic reactivation and provide evidence that lysine acetylation regulates LANA interactions with chromatin, Sp1, and ORF50 promoter DNA...
  38. pmc Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae
    P S Moore
    Division of Epidemiology, Columbia University, New York, New York 10032, USA
    J Virol 70:549-58. 1996
    ..These studies define the agent as a new human herpesvirus provisionally assigned the descriptive name KS-associated herpesvirus; its formal designation is likely to be human herpesvirus 8...
  39. ncbi Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas
    Harriette J Kahn
    Department of Pathology, Women s College Campus, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Mod Pathol 15:434-40. 2002
    ..We conclude that D2-40 is a new selective marker of lymphatic endothelium in normal tissues and vascular lesions and is valuable for studying benign and malignant vascular disorders in routinely processed tissue specimens...
  40. pmc Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator
    Hiroyuki Nakamura
    Department of Microbiology and Molecular Genetics, Division of Tumor Virology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 77:4205-20. 2003
    ..Thus, our streamlined gene expression system provides a novel means not only to study the effects of viral gene products on overall KSHV gene expression and replication, but also to understand the natural viral reactivation process...
  41. ncbi Impact of highly active antiretroviral therapy on the presenting features and outcome of patients with acquired immunodeficiency syndrome-related Kaposi sarcoma
    Guglielmo Nasti
    Division of Medical Oncology A, Italian National Cancer Institute, Aviano, Italy
    Cancer 98:2440-6. 2003
    ..study was to evaluate the impact of highly active antiretroviral therapy (HAART) on clinical characteristics of presentation and the natural history of Kaposi sarcoma (KS) in patients already receiving HAART at the time of KS diagnosis.
  42. pmc KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice
    Christopher H Parsons
    Myles H Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, University of Virginia Health Systems, Charlottesville, Virginia 22908, USA
    J Clin Invest 116:1963-73. 2006
    To develop an animal model of Kaposi sarcoma-associated herpesvirus (KSHV) infection uniquely suited to evaluate longitudinal patterns of viral gene expression, cell tropism, and immune responses, we injected NOD/SCID mice intravenously ..
  43. ncbi Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection
    Pramod P Naranatt
    Department of Microbiology, Molecular Genetics and Immunology, Bioinformatics Core, and Microarray Core, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Cancer Res 64:72-84. 2004
    ....
  44. ncbi Primary Kaposi's sarcoma of the appendix: a rare cause of appendicitis
    Goswin Y Meyer-Rochow
    ANZ J Surg 77:402-3. 2007
  45. pmc More on HIV-associated Kaposi's sarcoma
    Susan E Krown
    N Engl J Med 358:535-6; author reply 536. 2008
  46. pmc An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease
    Thomas S Uldrick
    HIV and AIDS Malignancy Branch, National Cancer Institute Frederick, Frederick, MD, USA
    Clin Infect Dis 51:350-8. 2010
    b>Kaposi sarcoma-associated herpesvirus (KSHV) is the causal agent for Kaposi sarcoma (KS) and multicentric Castleman disease (MCD) in human immunodeficiency virus (HIV)-infected patients...
  47. ncbi Identifying human herpesvirus 8 infection: performance characteristics of serologic assays
    E A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    J Acquir Immune Defic Syndr 23:346-54. 2000
    ..Overall, assays performed adequately for use in most epidemiologic investigations, but wider applications will require improved tests...
  48. pmc Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus
    Dimitrios Lagos
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Paul O Gorman Building, Huntley Street, University College London, London WC1E 6BT, UK
    Cell Host Microbe 4:470-83. 2008
    ..We show that infection of endothelial cells with Kaposi sarcoma herpesvirus (KSHV), a human oncogenic virus, leads to rapid suppression of TLR4 expression...
  49. ncbi Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma
    T R O'Brien
    Viral Epidemiology Branch, National Cancer Institute, EPS 8016, Rockville, MD 20852, USA
    J Infect Dis 180:1010-7. 1999
    ..5 months). This study shows an epidemic of HHV-8 among US homosexual men in the early 1980s that was associated with a high risk of developing KS...
  50. ncbi Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis
    Kwun Wah Wen
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Lett 289:140-50. 2010
    b>Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily...
  51. ncbi Antibodies to human herpesvirus 8 latent and lytic antigens in blood donors and potential high-risk groups in Sweden: variable frequencies found in a multicenter serological study
    M Enbom
    Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Med Virol 62:498-504. 2000
    ..1 ELISA to be highly specific and also showed a good agreement between two of the immunofluorescence assays. However, generally there was a poor correlation for positive results, indicating the need of further methodological development...
  52. ncbi Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review
    R Casalone
    Laboratorio di Citogenetica e Genetica, Ospedale di Circolo e Università dell Insubria, Viale Borri 57, 21100, Varese, Italy
    Cancer Genet Cytogenet 124:16-9. 2001
    The karyotype of a new tumorigenic Kaposi sarcoma (KS)-derived cell line, as defined by cytogenetic and fluorescence in situ hybridization (FISH) analysis is 49,XY,i(1)(q10),i(7)(p10),+i(7) (q10),+der(8)t(8;13)(p11;q11),-13,+del(14)(q22),+..
  53. ncbi Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma
    P S Gill
    Kenneth Norris Jr Comprehensive Cancer Center and Hospital, University of Southern California, School of Medicine, Los Angeles, USA
    J Clin Oncol 14:2353-64. 1996
    ..To compare the safety and efficacy of liposomal daunorubicin (DaunoXome; NeXstar Pharmaceuticals, Inc, Boulder, CO) with a reference regimen of doxorubicin, bleomycin, and vincristine (ABV) in advanced AIDS-related Kaposi's sarcoma (KS)...
  54. ncbi HIV-associated Kaposi sarcoma in African children
    L Feller
    Department of Periodontology and Oral Medicine, School of Oral Health Sciences, University of Limpopo, Medunsa Campus, South Africa
    SADJ 65:20-2. 2010
    HIV-associated Kaposi sarcoma (HIV-KS) is common in African countries where HIV infection is pandemic and anti-retroviral medication is not readily available...
  55. ncbi In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Mol Immunol 44:1352-60. 2007
    b>Kaposi sarcoma Herpes virus (KSHV), also known as human Herpes virus 8 (HHV8), can persist as episome in target cells...
  56. ncbi Classic type of Kaposi's sarcoma and human herpesvirus 8 infection in Xinjiang, China
    P Dilnur
    Second Department of Pathology, Tokyo Medical University, Japan
    Pathol Int 51:845-52. 2001
    ....
  57. pmc Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Pathog 5:e1000389. 2009
    ..novel real-time QPCR method (i) to define progressive stages of endothelial cell transformation cumulating in Kaposi sarcoma (KS) and (ii) to identify specific miRNAs that serve as biomarkers for tumor progression...
  58. ncbi Comparison of serologic responses between Kaposi's sarcoma-positive and -negative men who were seropositive for both human herpesvirus 8 and human immunodeficiency virus
    Naoki Inoue
    Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Virol 74:202-6. 2004
    ..These results suggest that there is a difference in serologic response against ORF73 between the HIV patients with and without KS...
  59. pmc Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoter
    Nathalie Cloutier
    Laboratory of Virology, Rheumatology and Immunology Research Center, Centre Hospitalier Universitaire de Quebec Research Center and Faculty of Medicine, Laval University, Quebec City, Quebec G1V 4G2, Canada
    J Biol Chem 285:7208-21. 2010
    ..The Kaposi sarcoma-associated herpesvirus (KSHV) encodes multiple proteins expressed during the lytic replication cycle that ..
  60. ncbi Lymphangioma-like Kaposi sarcoma
    James A Ramirez
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cutan Pathol 32:286-92. 2005
    ..In this study, we present the clinical and pathological features of four patients with LLKS...
  61. ncbi Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium
    Rizwan Masood
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 105:1310-8. 2005
    b>Kaposi sarcoma (KS) is an angioproliferative tumor derived from endothelial cells in which tumor cells form aberrant vascular structures...
  62. ncbi Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma
    Salvatore Di Paolo
    Department of Emergency and Organ Transplants, Division of Nephrology, Dialysis and Transplantation, University of Bari, Policlinico Piazza Giulio Cesare, 11 70124 Bari, Italy
    Am J Kidney Dis 49:462-70. 2007
    ..to explore mTOR signaling in peripheral-blood mononuclear cells (PBMCs) from renal transplant recipients with Kaposi sarcoma and ascertain whether it would reflect deregulation of the AKT-mTOR pathway in skin cancer tissue and might ..
  63. ncbi Latent and lytic HHV-8 mRNA expression in PBMCs and Kaposi's sarcoma skin biopsies of AIDS Kaposi's sarcoma patients
    Abeltje M Polstra
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 70:624-7. 2003
    ..Thus, the HHV-8 DNA load in the PBMCs increases in more advanced Kaposi's sarcoma, as does the frequency of mRNA detection in PBMCs...
  64. pmc Epidemiology of classic Kaposi's sarcoma in the Israeli Jewish population between 1960 and 1998
    E Guttman-Yassky
    Department of Dermatology, Rambam Medical Center, Haifa, Israel
    Br J Cancer 89:1657-60. 2003
    ..World standardised incidence rates of 20.7 and 7.5 per million among men and women, respectively, were calculated. The highest incidence rates were displayed by men originated from Africa and by Asian-born women...
  65. pmc Randomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus-associated Kaposi sarcoma: evidence of symptom palliation from chemotherapy
    Mary Cianfrocca
    Department of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer 116:3969-77. 2010
    ..PLD) are active cytotoxic agents for the treatment of human immunodeficiency virus (HIV)-associated Kaposi sarcoma (KS)...
  66. ncbi Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirus
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer and Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Mod Pathol 16:424-9. 2003
    ..We conclude that Kaposi's sarcoma-associated herpesvirus is present in some immunoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma...
  67. ncbi Detection and quantification of Kaposi's sarcoma-associated herpesvirus to predict AIDS-associated Kaposi's sarcoma
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    AIDS 17:1847-51. 2003
    ..To identify immunologic and virologic predictors of AIDS-associated Kaposi's sarcoma (KS)...
  68. pmc Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation
    Patrick A Carroll
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Virology 328:7-18. 2004
    ..These studies support the hypotheses that latent KSHV infection of blood endothelial cells drives their differentiation to lymphatic endothelial cells...
  69. ncbi Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells
    Shane C McAllister
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, USA
    Blood 103:3465-73. 2004
    b>Kaposi sarcoma (KS) is the most common AIDS-associated malignancy and is characterized by angiogenesis and the presence of spindle cells...
  70. ncbi High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma
    S T P Deloose
    Department of Pathology Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Leukemia 19:851-5. 2005
    b>Kaposi sarcoma-associated herpesvirus (KSHV) is known to be associated with two distinct lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)/MCD-associated plasmablastic lymphoma...
  71. ncbi Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma
    Josep M Campistol
    Renal Transplant Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Transplantation 77:760-2. 2004
    ..Sirolimus offers a new and promising approach to the management of posttransplantation KS and probably to other types of malignancies in organ transplant recipients...
  72. ncbi Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma
    Elizabeth E Brown
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer 107:2282-90. 2006
    Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm that develops in the presence of KS-associated herpesvirus (KSHV) and immune perturbation...
  73. ncbi Predictors of immune reconstitution inflammatory syndrome-associated with kaposi sarcoma in mozambique: a prospective study
    Emilio Letang
    Centro de Investigação em Saúde de Manhiça CISM, Manhiça, Maputo, Mozambique
    J Acquir Immune Defic Syndr 53:589-97. 2010
    The impact and relevance of immune reconstitution inflammatory syndrome-associated with Kaposi sarcoma (IRIS-KS) has not been assessed in sub-Saharan African countries, where the bulk of HIV-1 and KS-associated herpesvirus (KSHV) ..
  74. ncbi Biology of Kaposi's sarcoma
    B Ensoli
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Eur J Cancer 37:1251-69. 2001
    ....
  75. ncbi Weekly paclitaxel for advanced aggressive classic Kaposi sarcoma: experience in 17 cases
    L Brambilla
    Institute of Dermatological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milan, Italy
    Br J Dermatol 158:1339-44. 2008
    Paclitaxel has proved to be highly effective in the treatment of severe AIDS-related Kaposi sarcoma (KS), for which it is now considered as a second-line monotherapy...
  76. ncbi Coexistent Kaposi sarcoma, cryptococcosis, and Mycobacterium avium intracellulare in a solitary cutaneous nodule in a patient with AIDS: report of a case and literature review
    Thomas A Pietras
    University of Iowa Roy and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
    J Am Acad Dermatol 62:676-80. 2010
    We present a report of a 63-year-old man with AIDS who was diagnosed with coexistent Kaposi sarcoma (KS), Cryptococcus neoformans, and Mycobacterium avium intracellulare in a single, solitary lesion...
  77. ncbi Virology, pathogenetic mechanisms, and associated diseases of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8)
    Ronit Sarid
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mayo Clin Proc 77:941-9. 2002
    b>Kaposi sarcoma-associated herpesvirus (KSHV) is a recently discovered and characterized member of the herpesvirus family. It is one of a few viruses proved to be associated with tumorigenesis in humans...
  78. pmc Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response
    Huong Q Nguyen
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 22:937-45. 2008
    To evaluate the role of highly active antiretroviral therapy and chemotherapy on tumor response among persons with AIDS-related Kaposi sarcoma and identify factors associated with response in a clinic setting.
  79. ncbi HHV-8-associated Kaposi sarcoma in a child with IFNgammaR1 deficiency
    Yildiz Camcioglu
    Department of Pediatrics, Infectious Diseases and Clinical Immunology Division, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey
    J Pediatr 144:519-23. 2004
    Mediterranean classic Kaposi sarcoma (KS) of childhood is rare and unexplained. Our objective is to describe the case of a child with complete IFNgammaR1 deficiency and severe mycobacterial disease in whom Kaposi sarcoma (KS) developed.
  80. pmc Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis
    Sonja Koopal
    Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Finland
    PLoS Pathog 3:1348-60. 2007
    b>Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)-infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA...
  81. ncbi Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agents
    B Ensoli
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Cytokine Growth Factor Rev 9:63-83. 1998
    ..However, given time, reactive KS may progress to a sarcoma as suggested by evidence of monoclonality in late-nodular lesions...
  82. ncbi Use of liposomal anthracyclines in Kaposi's sarcoma
    Susan E Krown
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Oncol 31:36-52. 2004
    ..Health-related quality of life was improved in several domains in patients treated with PLD or DNX compared with ABV...
  83. ncbi Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma
    Anil Tulpule
    Division of Hematology, Department of Medicine, Kenneth Norris Cancer Hospital and Research Institute, University of Southern California School of Medicine, Los Angeles, California, USA
    Cancer 95:147-54. 2002
    Treatment options are limited for patients with advanced acquired immunodeficiency syndrome (AIDS)-related Kaposi sarcoma (AIDS-KS) whose disease has progressed after receiving therapy with liposomal anthracyclines or combination ..
  84. ncbi Solid tumors after chronic lymphocytic leukemia
    M Hisada
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Blood 98:1979-81. 2001
    ..19). Significant excesses were found for Kaposi sarcoma (O/E = 5.09), malignant melanoma (O/E = 3.18), and cancers of the larynx (O/E = 1.72) and the lung (O/E = 1...
  85. ncbi Geographic variation in the prevalence of Kaposi sarcoma-associated herpesvirus and risk factors for transmission
    Silvia de Sanjose
    Institut Catala d Oncologia, and 2Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública, Barcelona, Spain
    J Infect Dis 199:1449-56. 2009
    The aim of the present study was to estimate the prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in the female general population, to define geographic variation in and heterosexual transmission of the virus.
  86. ncbi Regression of Kaposi's sarcoma in renal graft recipients after conversion to sirolimus treatment
    S C Zmonarski
    Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland
    Transplant Proc 37:964-6. 2005
    ..It is difficult to ascertain whether KS regression may be attributed to sirolimus treatment or to the reduced overall immunosuppression...
  87. ncbi Lymph nodes involved by multicentric Castleman disease among HIV-positive individuals are often involved by Kaposi sarcoma
    Kikkeri N Naresh
    Department of Histopathology, Hammersmith Hospital and Imperial College, London, UK
    Am J Surg Pathol 32:1006-12. 2008
    Multicentric Castleman disease (MCD), a lymphoproliferative disorder and Kaposi sarcoma (KS), a vascular tumor, both occur at a higher frequency among patients with human immunodeficiency virus (HIV) infection...
  88. ncbi Risk factors for Kaposi's sarcoma: a case-control study of HIV-seronegative people in Uganda
    John Ziegler
    Uganda Cancer Institute and Makerere University Medical School, Kampala, Uganda
    Int J Cancer 103:233-40. 2003
    ..7; p < 0.001). The risk of Kaposi's sarcoma is clearly linked to antibody status for KSHV, but it would seem that in Uganda other factors are also important in the development of the tumour...
  89. pmc Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells
    Ling Wang
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Res 68:4640-8. 2008
    ..Collectively, these results suggest that KSHV infection of endothelial cells modulates cell signaling pathways and induces cell survival and angiogenesis, thereby contributing to the pathogenesis induced by KSHV...
  90. ncbi The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo
    Emmy W Verschuren
    Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94115, USA
    Cancer Cell 2:229-41. 2002
    ..However, in the absence of p53, such cells survive and expand as an aneuploid population. Corroborating these findings, in vivo Emu; K cyclin expression cooperates with p53 loss in the induction of lymphomas...
  91. ncbi A nuclear role for Kaposi's sarcoma-associated herpesvirus-encoded K13 protein in gene regulation
    H Matta
    Department of Medicine, Division of Hematology Oncology, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    Oncogene 27:5243-53. 2008
    ....
  92. ncbi AIDS-related Kaposi's Sarcoma: evaluation of potential new prognostic factors and assessment of the AIDS Clinical Trial Group Staging System in the Haart Era--the Italian Cooperative Group on AIDS and Tumors and the Italian Cohort of Patients Naive From A
    Guglielmo Nasti
    Division of Medical Oncology A, National Cancer Institute, Aviano PN, Italy
    J Clin Oncol 21:2876-82. 2003
    ..To assess potential new prognostic factors and to validate the AIDS Clinical Trials Group (ACTG) for AIDS-related Kaposi's sarcoma (AIDS-KS) staging system in the highly active antiretroviral therapy (HAART) era...
  93. ncbi Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy
    Elizabeth Connick
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
    Clin Infect Dis 39:1852-5. 2004
    Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated ..
  94. pmc Molecular virology of Kaposi's sarcoma-associated herpesvirus
    P S Moore
    School of Public Health and Department of Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Philos Trans R Soc Lond B Biol Sci 356:499-516. 2001
    ..However, due to the overlapping nature of innate immune and tumour-suppressor pathways, inhibition of these regulatory networks can lead to unregulated cell proliferation and may contribute to virus-induced tumorigenesis...
  95. ncbi Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling
    Christine L Curry
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    Mol Cancer Ther 6:1983-92. 2007
    ..Taken together, these studies suggest that Notch inhibition can initiate aberrant mitosis by inducing NF-kappaB activity that inappropriately increases cyclin B1 resulting in cell death via mitotic catastrophe...
  96. pmc HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway
    Elena Toschi
    AIDS National Center, Istituto Superiore di Sanita, 00161 Rome, Italy
    Mol Biol Cell 17:1985-94. 2006
    ..Taken together, these data provide novel evidence about the ability of Tat to activate the Ras-ERK cascade which may be relevant for endothelial cell proliferation and for Kaposi's sarcoma progression...
  97. pmc Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells
    G Miller
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 71:314-24. 1997
    ..The differential inducibility of these two herpesviruses in the same cell line points to the importance of viral factors in the switch from latency to lytic cycle...
  98. ncbi Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia
    Dimitra Bourboulia
    Wolfson Institute for Biomedical Research and the Department of Sexually Transmitted Diseases, University College London, London, UK
    AIDS 18:485-93. 2004
    To investigate the effect of highly active antiretroviral therapy (HAART) on Kaposi sarcoma-associated herpesvirus (KSHV) DNA load, anti-KSHV antibody responses and KSHV-specific CD8 T cell responses in HIV-infected individuals over a 2 ..
  99. ncbi The sero-epidemiology of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in adults with cancer in Uganda
    Robert Newton
    Cancer Research UK, Epidemiology Unit, Radcliffe Infirmary, Oxford, United Kingdom
    Int J Cancer 103:226-32. 2003
    ..03). In conclusion, in this population in Uganda, where KSHV is relatively common, the prevalence of anti-KSHV antibodies increased with age but showed little association with nearly 50 other factors studied...
  100. doi Transmission of Kaposi sarcoma-associated herpesvirus in sub-Saharan Africa
    Sam M Mbulaiteye
    AIDS 22:535-7. 2008
  101. ncbi Cancer risk in people infected with human immunodeficiency virus in the United States
    Eric A Engels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 123:187-94. 2008
    ..Risk was elevated for Kaposi sarcoma (KS, SIR 1,300 [n = 173 cases]), non-Hodgkin lymphoma (NHL, 7.3 [n = 203]), cervical cancer (2...

Research Grants62

  1. Targeting Kinases that Phosphorylate the KSHV LANA Chromatin Binding Domain
    S Diane Hayward; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): KSHV is associated with the endothelial malignancy Kaposi sarcoma (KS) and the B cell cancers primary effusion lymphoma (PEL) and multicentric Castleman disease...
  2. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward H Egelman; Fiscal Year: 2012
    ..1 Virus (HSV-1) ICP8, but will then be extended to related viral proteins, such as from Epstein Barr Virus and Kaposi Sarcoma Herpes Virus...
  3. Epigenetic regulation of viral infection and replication by periodontal bacteria
    Fengchun Ye; Fiscal Year: 2013
    ..more frequent infections by herpesviruses such as herpes simplex virus (HSV), Epstein Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (KSHV). The oral cavity is also a potential reservoir for latent HIV infection...
  4. Human Herpesvirus-8 Replication and Kaposi Sarcoma Response to Treatment
    Warren Phipps; Fiscal Year: 2013
    ..training program which will allow him to develop a career as an independent investigator in the field of Kaposi sarcoma (KS) and HIV-associated malignancies...
  5. Transport and Insertion of Outer Membrane Proteins
    Sangita Sinha; Fiscal Year: 2009
    ..virus which causes infectious mononucleosis and malignant tumors of lymphoid and epithelial tissues and Kaposi Sarcoma virus, which causes Kaposi sarcoma tumors, especially among immunocompromised individuals such as AIDS ..
  6. The role of cell surface heat shock protein 90 in KSHV pathogenesis
    MICHAEL ROBERT DEFEE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kaposi sarcoma (KS) is the most common cancer arising in HIV- infected individuals with as many as 60% of cases involving the oral cavity...
  7. Targeted Therapies for HIV-Associated Kaposi Sarcoma and Lymphoma
    Dirk P Dittmer; Fiscal Year: 2013
    ..This includes, even to date, the AIDS-defining cancers Kaposi sarcoma (KS) and lymphoma, such as primary effusion lymphoma...
  8. Interferon Alpha Regulation of Murine Gammaherpesvirus Latency
    Erik S Barton; Fiscal Year: 2013
    ..of mice and displays genetic and pathologic similarities to the human ?-herpesviruses Epstein-Barr virus and Kaposi Sarcoma herpesvirus...
  9. Characterization of ER-localized Activity of HHV-8 Interleukin-6
    EMILY MARIE COUSINS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) has been etiologically linked to Kaposi sarcoma, multicentric Castleman's disease, and primary effusion lymphoma (PEL)...
  10. Early Events in KSVH Infection of Primary B-cells
    Erle S Robertson; Fiscal Year: 2013
    ..associated herpesvirus (KSHV/HHV-8) is associated with a number of human cancers in particular AIDS associated Kaposi sarcoma (KS) and pleural effusion lymphomas (PELs)...
  11. Columbia-South Africa Training Program for Research on HIV-associated Malignanci
    Alfred I Neugut; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In sub-Saharan Africa, Kaposi sarcoma (KS) and non-Hodgkin lymphoma (NHL) incidence and mortality rates have risen dramatically as the HIV/AIDS epidemic has evolved...
  12. Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and Neutralization
    Ronald C Desrosiers; Fiscal Year: 2012
    ..of rhesus monkeys, rhesus monkey rhadinovirus (RRV), will be used as a model of human herpesvirus 8 (HHV-8;the Kaposi sarcoma-associated herpesvirus) to define the viral glycoproteins required for entry into different types of target ..
  13. Peptide-mediated immunotherapy of KSHV-associated malignancy.
    Jae U Jung; Fiscal Year: 2010
    ..Area: 5-DE-109 Novel Immunotherapies to Treat HIV/AIDS-related Oral Manifestations and AIDS Malignancies Kaposi sarcoma (KS), specifically oral KS, is the leading cause of cancer in patients with HIV infection...
  14. Herpresviral Gene Expression in Kaposis Sarcoma
    Don Ganem; Fiscal Year: 2010
    ..By determining how viral infection leads to KS, we hope to identify molecular targets that can explain how the disease arises;these could also serve as targets for the therapies of the future. ..
  15. Herpesviral, Oncogenesis, Latency and Reactivation
    NANCY JOAN RAAB-TRAUB; Fiscal Year: 2013
    ..applicant): The program continues its focus on the human oncogenic herpesvirus, Epstein-Barr Virus (EBV) and Kaposi Sarcoma-associated Herpesvirus (KSHV) to identify the critical mechanisms by which these agents induce cancer and ..
  16. Impact of HIV and HHV-8 Co-Infection on Antiretroviral Therapy Efficacy in Africa
    Corey Casper; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kaposi sarcoma (KS), the most common HIV-associated malignancy worldwide, is attributable to infection with human herpesvirus 8 (HHV-8)...
  17. VEGFs in Artery-Vein Imbalance in AIDS-Kaposi Sarcoma
    Parkash Gill; Fiscal Year: 2009
    ..This work is anticipated to enhance our understanding of KS pathogenesis, provide opportunities for novel therapies for KS, and contribute to the understanding of vascular biology. ..
  18. CRITICAL ROLE OF HHV8 ENCODED IRF IN AIDS LYMPHOMAS
    PAULA PITHA ROWE; Fiscal Year: 2001
    DESCRIPTION: Two major AIDS-associated malignancies are Kaposi sarcoma (KS) and Non-Hodgkin's lymphoma (NHL)...
  19. KAPOSIS SARCOMA ASSOCIATED VIRUS IN AIDS/LYMPHOMAS
    Ethel Cesarman; Fiscal Year: 1999
    ..This will lead to a better understanding of a novel human herpesvirus which appears to be playing a relevant role in the malignant transformation of a subset of AIDS-associated lymphomas. ..
  20. HERPESVIRUS PERSISTENCE AND ONCOGENICITY
    Thomas Shenk; Fiscal Year: 2004
    ..simplex type 1 virus and pseudorabies virus; beta, human cytomegalovirus; and gamma, Epstein- Barr virus and Kaposi sarcoma-associated herpes virus...
  21. MIAMI ADULT AIDS CLINICAL TRIALS GROUP, AACTG
    Margaret Fischl; Fiscal Year: 2006
    ..pathogenesis and treatment, HIV dementia pathogenesis and treatment and peripheral neuropathy pain assessment, Kaposi sarcoma (KS) pathogenesis, intensive immunologic monitoring and definition, and validation of immunologic determinants ..
  22. HHV-8 VIRAL LOAD AND PROGRESSION TO KAPOSIS SARCOMA
    Frank Jenkins; Fiscal Year: 2000
    ..These results will also determine the rate of occurrence of detectable levels of HHV-8 DNA in the PBMCs from the time of HHV-8 seroconversion to the onset of KS. ..
  23. ART Modulation of Viral Pathogenesis
    Dirk P Dittmer; Fiscal Year: 2013
    ..HIV replication to below 50 copies / ml, not much is known about the long-term effect of these ART drugs on Kaposi sarcoma associated herpesvirus (KSHV) transmission and disease...
  24. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ....
  25. CHARACTERIZATION SIGNAL TRANSDUCTION IN KAPOSIS SARCOMA
    Ramesh Ganju; Fiscal Year: 2002
    ..This structured approach to characterize cytokine, chemokine and TAT signaling pathways and their functional roles in KS spindle cells should provide insight into the mechanisms of KS growth and spread. ..
  26. MECHANISMS OF THE HSV-1 UL42 PROTEIN
    DEBORAH PARRIS; Fiscal Year: 2002
    ..Functional analogs of HSV-1 pol and UL42 are encoded by all human herpesviruses, including Kaposi sarcoma-associated virus (HHV-8), Epstein Barr virus, and human cytomegalovirus, all of which are significant human ..
  27. LATENCY AND TRANSFORMATION BY HERPESVIRUSES
    Brian Wigdahl; Fiscal Year: 1990
    ..Furthermore, HSV and HCMV have been associated with human neoplasia; cervical carcinoma and Kaposi sarcoma, respectively...
  28. PROTECTION AGAINST IL12 TOXICITY BY CNI1493
    CLARISSA NAFTZGER; Fiscal Year: 1999
    ..of a drug that will extend the use of IL-12 to a variety of cancers, including melanoma, renal carcinoma, Kaposi sarcoma as well as others...
  29. HHV 8 AND KAPOSIS SARCOMA
    Brian Nickoloff; Fiscal Year: 2000
    ..By successfully completing all 4 aims over the next 4 years, a better understanding of the etiology and pathophysiology of this common, enigmatic, and potentially deadly neoplasm will be had ..
  30. ACTIVATION OF KAPOSI SARCOMA-ASSOCIATED HERPES VIRUS
    I Miller; Fiscal Year: 2003
    ..The studies should provide insights into molecular pathogenesis of KSHV-associated disease and address fundamental questions about control of oncogenic herpesvirus gene expression. ..
  31. DEVELOPMENT OF HHV-8 DETECTION/NEUTRALIZATION REAGENTS
    Yi chun Wang; Fiscal Year: 2001
    ....
  32. IMMUNOBIOLOGY OF HHV8 IN KAPOSIS SARCOMA
    David Scadden; Fiscal Year: 2000
    ....
  33. EPIDEMIOLOGY OF CLASSIC KAPOSIS SARCOMA
    Nancy Mueller; Fiscal Year: 1992
    ..By combined serologic, immunologic and interview information, a comprehensive screening for risk factors and evaluation of roles of the CMV and HTLV's should be achieved...
  34. ELECTRON MICROSCOPE TO DEFINE MICROBIAL/HOST INTERACTION
    Ruth Nussenzweig; Fiscal Year: 1992
    ..regulation of sporulation in Bacilli; g) characterize the ENV proteins of the AIDS virus and investigate the viral etiology and pathogenesis of Kaposi sarcoma and h) investigate the viral and cellular gene expression of growth regulation.
  35. PATHOGENISIS OF KAPOSI'S SARCOMA
    Parkash Gill; Fiscal Year: 1993
    The goal of this proposal is to elucidate the pathogenesis of Kaposi sarcoma (KS) in the presence or absence of IEV infection, based on the hypothesis that glucocorticoids and certain cytokines/monokines (IL-l, TNF, IL-6, novel growth ..
  36. CD34+ PROGENITOR IN PATHOGENESIS OF AIDS KAPOSI SARCOMA
    ENRIQUE MESRI; Fiscal Year: 1999
    ..The results of this study will provide important insights into the pathogenesis of AIDS-KS and will foster development of novel mechanistic and intervention studies for AIDS-KS. ..
  37. BCL-XS MEDIATED APOPTOSIS OF KAPOSI SARCOMA CELLS
    Gabriel Nunez; Fiscal Year: 1999
    ....
  38. Validating VIL-6 as a target for KSHV-associated disease
    Scott Wong; Fiscal Year: 2005
    ..The results should help elucidate the role of the vlL-6 in virus infection and provide new insights into the future development of diagnostics and therapies for gamma-2 herpesvirus-induced malignancies. ..
  39. REGULATION OF APOPTOSIS IN AIDS RELATED KAPOSIS SARCOMA
    Kimberly Foreman; Fiscal Year: 2002
    ..Such new treatment options are important for AIDS patients who frequently develop this deadly neoplasm. ..
  40. REGULATION OF ANGIOGENESIS BY HUMAN HERPESVIRUS 8
    Sankar Swaminathan; Fiscal Year: 2000
    ..To determine the role of two Kaposi sarcoma-associated herpesvirus trans-activating genes (Rta and ORF57) in the regulation of endothelial cell genes ..
  41. EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA
    Lisa Jacobson; Fiscal Year: 1999
    ....
  42. 9 CIS-RETINOIC ACID AND INTERFERON-A IN KAPOSIS SARCOMA
    Leonard Liebes; Fiscal Year: 1999
    ..In addition, we have ample patient resources as well as a strong support structure to ensure the successful completion of the proposed research. ..
  43. KAPOSIS SARCOMA ASSOCIATED HERPESVIRUS DNA REPLICATION
    Peter Medveczky; Fiscal Year: 2000
    ..The first is to identify ori P of KSHV. The second is to map the initiation site and direction of replication. The third aim is to search for the transactivator. This study should lead to better understanding of latency. ..
  44. KSHV Modulation of the Host Innate Immune System
    John West; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: KSHV is associated with three types of cancer in humans;Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD)...
  45. ORAL IMPLICATIONS OF HUMAN HERPES VIRUS 8 (HHV8)
    Stephen Porter; Fiscal Year: 1999
    ..A limited cohort and study will be done on HIV-1 positive patients to determine parameters associated with the development of oral KS. ..
  46. Hunter Killer Peptides: Membrane Interactions and Receptor Binding
    Leigh Plesniak; Fiscal Year: 2007
    ..was designed to target tumor vasculature, and has been shown to be effective against breast cancer cells and kaposi sarcoma. A second HKP that kills white fat tissue reduces fatty deposits and has a positive impact on glucose ..
  47. Survival Signals in AIDS Lymphomas
    Ethel Cesarman; Fiscal Year: 2010
    ..Our data will help elucidate how best to inhibit EBV to improve the treatment of AIDS patients with lymphoma. ..
  48. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  49. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
  50. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
    Susan Mallery; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. KSHV TRANSFORMATION AND ANGIOGENESIS IN KAPOSIS SARCOMA
    Ethel Cesarman; Fiscal Year: 2001
    ..These studies will also provide information that will enrich our general knowledge of viral oncogenesis. ..