chickenpox

Summary

Summary: A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)

Top Publications

  1. ncbi Using time-use data to parameterize models for the spread of close-contact infectious diseases
    Emilio Zagheni
    Department of Demography, University of California, Berkeley, 2232 Piedmont Avenue, Berkeley, CA 94720 2120, USA
    Am J Epidemiol 168:1082-90. 2008
  2. pmc Epidemiology of varicella zoster virus infection in Canada and the United Kingdom
    M Brisson
    PHLS CDSC, and City University, London
    Epidemiol Infect 127:305-14. 2001
  3. ncbi Modelling the impact of a combined varicella and zoster vaccination programme on the epidemiology of varicella zoster virus in England
    Albert Jan van Hoek
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London NW9 5EQ, UK
    Vaccine 29:2411-20. 2011
  4. ncbi The health and economic burden of chickenpox and herpes zoster in Belgium
    J Bilcke
    Center for Health Economic Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute VAXINFECTIO, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
    Epidemiol Infect 140:2096-109. 2012
  5. ncbi The incidence of varicella and herpes zoster in Taiwan during a period of increasing varicella vaccine coverage, 2000-2008
    D Y Chao
    Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Epidemiol Infect 140:1131-40. 2012
  6. ncbi Clinical and molecular pathogenesis of varicella virus infection
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Viral Immunol 16:243-58. 2003
  7. ncbi Epidemiology of herpes zoster and its relationship to varicella in Japan: A 10-year survey of 48,388 herpes zoster cases in Miyazaki prefecture
    Nozomu Toyama
    Toyama Dermatologic Clinic, Nichinan City, Miyazaki, Japan
    J Med Virol 81:2053-8. 2009
  8. pmc Primary vaccine failure after 1 dose of varicella vaccine in healthy children
    David E Michalik
    Division of Pediatric Infectious Diseases, Columbia University Medical Center, New York, New York 10032, USA
    J Infect Dis 197:944-9. 2008
  9. pmc The seroepidemiology of varicella zoster virus among pregnant Bangladeshi and white British women in the London Borough of Tower Hamlets, UK
    Y S Talukder
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Queen Mary School of Medicine and Dentistry, London, UK
    Epidemiol Infect 135:1344-53. 2007
  10. pmc Gender difference in the incidence of shingles
    D M Fleming
    Birmingham Research Unit of the Royal College of General Practitioners, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK
    Epidemiol Infect 132:1-5. 2004

Research Grants

Detail Information

Publications340 found, 100 shown here

  1. ncbi Using time-use data to parameterize models for the spread of close-contact infectious diseases
    Emilio Zagheni
    Department of Demography, University of California, Berkeley, 2232 Piedmont Avenue, Berkeley, CA 94720 2120, USA
    Am J Epidemiol 168:1082-90. 2008
    ..Finally, the authors estimate age-specific transmission parameters for varicella, commonly known as "chickenpox," from age-specific time-of-exposure and seroprevalence data (United States, 1988-1994)...
  2. pmc Epidemiology of varicella zoster virus infection in Canada and the United Kingdom
    M Brisson
    PHLS CDSC, and City University, London
    Epidemiol Infect 127:305-14. 2001
    ..Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies...
  3. ncbi Modelling the impact of a combined varicella and zoster vaccination programme on the epidemiology of varicella zoster virus in England
    Albert Jan van Hoek
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London NW9 5EQ, UK
    Vaccine 29:2411-20. 2011
    ..At high coverage (90% and 80% coverage) this is unlikely to be the case. These results will be used to inform a cost-effectiveness analysis of combined varicella and zoster vaccination programmes...
  4. ncbi The health and economic burden of chickenpox and herpes zoster in Belgium
    J Bilcke
    Center for Health Economic Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute VAXINFECTIO, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
    Epidemiol Infect 140:2096-109. 2012
    Varicella-zoster virus causes chickenpox (CP) and after reactivation herpes zoster (HZ). Vaccines are available against both diseases warranting an assessment of the pre-vaccination burden of disease...
  5. ncbi The incidence of varicella and herpes zoster in Taiwan during a period of increasing varicella vaccine coverage, 2000-2008
    D Y Chao
    Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Epidemiol Infect 140:1131-40. 2012
    ..Continuous monitoring is needed to understand the secular trends in HZ before and after varicella vaccination in Taiwan and in other countries...
  6. ncbi Clinical and molecular pathogenesis of varicella virus infection
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Viral Immunol 16:243-58. 2003
    Varicella zoster virus (VZV) is a neurotropic human herpesvirus that infects nearly all humans and causes chickenpox (varicella)...
  7. ncbi Epidemiology of herpes zoster and its relationship to varicella in Japan: A 10-year survey of 48,388 herpes zoster cases in Miyazaki prefecture
    Nozomu Toyama
    Toyama Dermatologic Clinic, Nichinan City, Miyazaki, Japan
    J Med Virol 81:2053-8. 2009
    ..This large-scale survey clarifies the epidemiology of herpes zoster by age, gender, and season in relation to the prevalence of varicella in the Miyazaki Prefecture in Japan...
  8. pmc Primary vaccine failure after 1 dose of varicella vaccine in healthy children
    David E Michalik
    Division of Pediatric Infectious Diseases, Columbia University Medical Center, New York, New York 10032, USA
    J Infect Dis 197:944-9. 2008
    ..vaccine was recommended in the United States in 1995, and it has significantly decreased the incidence of chickenpox. Outbreaks of varicella, however, are reported among vaccinated children...
  9. pmc The seroepidemiology of varicella zoster virus among pregnant Bangladeshi and white British women in the London Borough of Tower Hamlets, UK
    Y S Talukder
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Queen Mary School of Medicine and Dentistry, London, UK
    Epidemiol Infect 135:1344-53. 2007
    ..63). This implies they will have an increased risk of varicella during pregnancy. Women arriving in the United Kingdom in adulthood should be screened routinely during pregnancy and vaccination offered postpartum if they are susceptible...
  10. pmc Gender difference in the incidence of shingles
    D M Fleming
    Birmingham Research Unit of the Royal College of General Practitioners, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK
    Epidemiol Infect 132:1-5. 2004
    ..Incidence rates of chickenpox and herpes simplex were examined similarly...
  11. ncbi The cost-effectiveness of varicella and combined varicella and herpes zoster vaccination programmes in the United Kingdom
    Albert Jan van Hoek
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, LondonNW9 5EQ, UK
    Vaccine 30:1225-34. 2012
    ..This study is the first to assess the cost-effectiveness of combined varicella and zoster vaccination options and compare this to alternative programmes...
  12. pmc Household size is critical to varicella-zoster virus transmission in the tropics despite lower viral infectivity
    Richard A Nichols
    School of Biological and Chemical Sciences, Queen Mary University of London, UK
    Epidemics 3:12-8. 2011
    ..VZV is spread by aerosol to cause chickenpox, which, in temperate countries, is a relatively benign childhood infection; yet in tropical countries it tends ..
  13. ncbi Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against chickenpox
    M Brisson
    Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, UK
    Vaccine 20:2500-7. 2002
    ..Mass varicella vaccination is expected to cause a major epidemic of herpes-zoster, affecting more than 50% of those aged 10-44 years at the introduction of vaccination...
  14. ncbi Modelling the impact of varicella vaccination on varicella and zoster
    M Karhunen
    National Institute for Health and Welfare THL, Department of Vaccination and Immune Protection, FI 00300 Helsinki, Finland
    Epidemiol Infect 138:469-81. 2010
    ..This will be due to increase in case numbers in the 35 years age groups. However, high vaccine coverage and a two-dose programme will be very effective in stopping varicella transmission in the population...
  15. ncbi Varicella prevention in the United States: a review of successes and challenges
    Mona Marin
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A 47, Atlanta, GA 30333, USA
    Pediatrics 122:e744-51. 2008
    ..The objective of this review was to summarize the US experience with the 1-dose varicella vaccination program, present the evidence considered for the policy change, and outline future challenges of the program...
  16. pmc The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features
    M A Nagel
    Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Neurology 70:853-60. 2008
    ..Not all patients have rash before cerebral ischemia or stroke. Furthermore, other vasculitides produce similar clinical features and comparable imaging, angiographic, and CSF abnormalities...
  17. ncbi Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlates
    B K Kleinschmidt-Demasters
    Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Pathol Lab Med 125:770-80. 2001
    ..Among the most diverse disorders caused by a single known toxic, metabolic, neoplastic, or infectious agent are the central and peripheral nervous system complications of varicella-zoster virus (VZV)...
  18. ncbi Safety of varicella vaccine after licensure in the United States: experience from reports to the vaccine adverse event reporting system, 1995-2005
    Sandra S Chaves
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 197:S170-7. 2008
    ..Ongoing safety surveillance and further studies may shed light on some of the hypothesized associations...
  19. pmc Review: The neurobiology of varicella zoster virus infection
    D Gilden
    Department of Neurology, University of Colorado School of Medicine, USA
    Neuropathol Appl Neurobiol 37:441-63. 2011
    ..Primary infection usually causes chickenpox (varicella), after which virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ..
  20. ncbi Assessment of varicella vaccine effectiveness in Germany: a time-series approach
    M Hohle
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Epidemiol Infect 139:1710-9. 2011
    ....
  21. ncbi Transmission of varicella vaccine virus to a non-family member in China
    Lin Gan
    Department of Microbiology, Anhui Medical University, Hefei, 230032, China
    Vaccine 29:2015-7. 2011
    ..This is the first report in China in which an adult with varicella was attributable to vaccine virus and the 6th report of transmission of vaccine virus to a susceptible adult around the world...
  22. pmc Latent simian varicella virus reactivates in monkeys treated with tacrolimus with or without exposure to irradiation
    Ravi Mahalingam
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurovirol 16:342-54. 2010
    ..These results indicate that tacrolimus treatment produced reactivation in more monkeys than irradiation and tacrolimus and irradiation increased the frequency of SVV reactivation as compared to either treatment alone...
  23. ncbi Serologic analysis of the IgG antibody response in children with varicella zoster virus wild-type infection and vaccination
    Andreas C W Jenke
    HELIOS Children s Hospital Wuppertal, Witten Herdecke University, Germany
    Pediatr Infect Dis J 31:1148-52. 2012
    ..Because more people get vaccinated every year, the development of sensitive serological test systems for the detection of protective anti-VZV IgG will become important in the future...
  24. ncbi Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccine
    Myron J Levin
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045 0508, USA
    J Infect Dis 198:1444-7. 2008
    ..The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that >1 variant strain may reactivate to cause herpes zoster...
  25. ncbi A decline in varicella but an uncertain impact on zoster following varicella vaccination in Victoria, Australia
    Kylie S Carville
    Epidemiology Unit, Victorian Infectious Diseases Reference Laboratory, Australia
    Vaccine 28:2532-8. 2010
    ..Among those aged 80 and over the hospitalisation rate increased 5% per year (95% CI 3-7%) from 1998 to 2007. Zoster increased in community data from 2001...
  26. pmc Decline in varicella-related ambulatory visits and hospitalizations in the United States since routine immunization against varicella
    Samir S Shah
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Infect Dis J 29:199-204. 2010
    ..Widespread varicella vaccination has led to substantial decreases in varicella-related mortality and hospitalizations. The effect of the vaccine on ambulatory care utilization is poorly defined...
  27. ncbi Prevention of varicella and zoster by live attenuated VZV vaccine
    Sophie Hambleton
    Children s Bone Marrow Transplant Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, United Kingdom
    Front Biosci 13:2696-704. 2008
    ..The potential of the newly licensed zoster vaccine to reduce viral circulation still further has yet to be evaluated...
  28. pmc Epidemiological characteristics of varicella from 2000 to 2008 and the impact of nationwide immunization in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    BMC Infect Dis 11:352. 2011
    ..Varicella has an important impact on public health. Starting in 2004 in Taiwan, nationwide free varicella vaccinations were given to 1-year-old children...
  29. pmc The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998-2003
    W Katherine Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, USA
    BMC Public Health 5:68. 2005
    ..While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella protects against reactivation of the varicella zoster virus...
  30. ncbi Impact of universal vaccination on the epidemiology of varicella in Veneto, Italy
    Francesca Pozza
    Direction of Prevention, Veneto Region, Venice, Italy
    Vaccine 29:9480-7. 2011
    ..There was a remarkable decline of both varicella incidence and hospitalizations especially in 1-4 year-old children. This study confirms the positive impact of universal vaccination...
  31. ncbi Chickenpox in childhood is associated with decreased atopic disorders, IgE, allergic sensitization, and leukocyte subsets
    Jonathan I Silverberg
    Department of Dermatology, St Luke s Roosevelt Hospital and Beth Israel Medical Centers, New York, NY 10025, USA
    Pediatr Allergy Immunol 23:50-8. 2012
    ..We sought to determine whether WTVZV in childhood protects against atopic disorders, allergic sensitization or decreases serum Immunoglobulin E (IgE) levels...
  32. ncbi Varicella in infants after implementation of the US varicella vaccination program
    Sandra S Chaves
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 128:1071-7. 2011
    ..To describe varicella disease in infants since implementation of the varicella vaccination program in the United States...
  33. ncbi One dose of varicella vaccine does not prevent school outbreaks: is it time for a second dose?
    Adriana S Lopez
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 117:e1070-7. 2006
    ....
  34. ncbi Scientific commentary
    Aisha Jumaan
    Vaccine 22:3228-31; author reply 3232-6. 2004
  35. ncbi Cost-effectiveness of varicella vaccination programs: an update of the literature
    Mark H Rozenbaum
    Groningen Research Institute of Pharmacy GRIP, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Expert Rev Vaccines 7:753-82. 2008
    ..Despite that, those aspects limit the timeliness of our review and we believe that the current work does provide useful insights in the cost-effectiveness of varicella vaccination...
  36. ncbi Current immunization policies for pneumococcal, meningococcal C, varicella and rotavirus vaccinations in Italy
    Valeria Alfonsi
    Istituto Superiore di Sanità ISS, National Center for Epidemiology Surveillance and Health Promotion CNESPS, Rome, Italy
    Health Policy 103:176-83. 2011
    ....
  37. ncbi The postmarketing safety profile of varicella vaccine
    R G Sharrar
    Worldwide Product Safety and Epidemiology, Merck Research Laboratories, BLB 30, PO Box 4, West Point, PA 19486, USA
    Vaccine 19:916-23. 2000
    ..Eleven patients were hospitalized with complications of breakthrough varicella infection...
  38. pmc Varicella-zoster virus infection of human dorsal root ganglia in vivo
    Leigh Zerboni
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:6490-5. 2005
    ..VZV-infected T cells transferred virus from the circulation into DRG, suggesting that VZV lymphotropism facilitates its neurotropism. DRG xenografts may be useful for investigating neuropathogenic mechanisms of other human viruses...
  39. pmc Hospitalization due to varicella in the Netherlands
    Alies van Lier
    Department of Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, RIVM, Postbox 1, 3720 BA Bilthoven, The Netherlands
    BMC Infect Dis 11:85. 2011
    ..Better knowledge about the severity of varicella among Dutch hospitalized patients is needed. Therefore, a medical record research was conducted among hospitalized patients with diagnosis varicella...
  40. ncbi Simian varicella virus reactivation in cynomolgus monkeys
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Virology 368:50-9. 2007
    ..Virus reactivation was confirmed not only by the occurrence of zoster in one monkey, but also by the presence of late SVV RNA in ganglia, and the detection of SVV DNA in non-ganglionic tissue, and SVV antigens in skin, ganglia and lung...
  41. ncbi The burden and cost of hospitalised varicella and zoster in Australian children
    Jonathan R Carapetis
    Department of Paediatrics, Murdoch Children s Research Institute, Royal Children s Hospital, University of Melbourne, Melbourne, Australia
    Vaccine 23:755-61. 2004
    ..Economic analyses of varicella-zoster virus (VZV) immunisation are sensitive to the costs of hospitalised cases, so there is a need to validate VZV hospitalisation data...
  42. ncbi An elementary school outbreak of varicella attributed to vaccine failure: policy implications
    Brian R Lee
    Immunization, Tuberculosis, and International Health Section, Infectious Disease Epidemiology, Prevention, and Control Division, Minnesota Department of Health, Minneapolis 55414, USA
    J Infect Dis 190:477-83. 2004
    ....
  43. ncbi Parental attitudes toward varicella vaccination. The Puget Sound Pediatric Research Network
    J A Taylor
    Department of Pediatrics, University of Washington School of Medicine, Seattle 98103 8652, USA
    Arch Pediatr Adolesc Med 154:302-6. 2000
    ..To evaluate parental health beliefs regarding the varicella vaccine and to identify potential areas for interventions designed to increase immunization against varicella...
  44. ncbi Neurologic varicella complications before routine immunization in Germany
    Anita L Rack
    Dr von Haunersches Kinderspital, University Children s Hospital Munich, Munich, Germany
    Pediatr Neurol 42:40-8. 2010
    ..Three patients died. The yearly incidence of neurologic varicella-associated hospitalizations was estimated at 2.4 neurologic complications per 100,000 children, corresponding to about one neurologic complication in 2000 varicella cases...
  45. ncbi Near elimination of varicella deaths in the US after implementation of the vaccination program
    Mona Marin
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 128:214-20. 2011
    ..Since then, vaccination coverage has increased substantially. We updated the analysis of US varicella mortality for 2002-2007 and assessed the impact of the first 12 years of the US varicella vaccination program on varicella deaths...
  46. ncbi Seroprevalence of Varicella-Zoster virus IgG antibodies in Swiss children during the first 16 months of age
    Ulrich Heininger
    Division of Pediatric Infectious Diseases, University Children s Hospital Basel, P O Box CH 4005, Basel, Switzerland
    Vaccine 24:3258-60. 2006
    ..To investigate the persistence of maternal IgG antibodies against Varicella-Zoster virus (VZV) in infants and young children...
  47. ncbi Simian varicella: a model for human varicella-zoster virus infections
    Wayne L Gray
    Department of Microbiology and Immunology, 4301 West Markham Street, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Rev Med Virol 14:363-81. 2004
    ..SVV is antigenically and genetically related to varicella-zoster virus (VZV), the etiologic agent of varicella (chickenpox) and herpes zoster (shingles) in humans...
  48. ncbi Chickenpox and stroke in childhood: a study of frequency and causation
    R Askalan
    Hospital for Sick Children and the University of Toronto, Toronto, Canada
    Stroke 32:1257-62. 2001
    ..Varicella-associated AIS has characteristic features, including a 2-fold increase in recurrent AIS and transient ischemic attacks. Varicella is an important risk factor for childhood AIS...
  49. pmc Varicella-Zoster virus pathogenesis and immunobiology: new concepts emerging from investigations with the SCIDhu mouse model
    Chia Chi Ku
    Stanford University School of Medicine, 300 Pasteur Dr, Room G 311, Stanford, CA 94305 5119, USA
    J Virol 79:2651-8. 2005
  50. pmc Phylogenetic analysis of varicella-zoster virus: evidence of intercontinental spread of genotypes and recombination
    Winsome Barrett Muir
    School of Medicine, Queen Mary College, University of London, London E1 1BB, England
    J Virol 76:1971-9. 2002
    ..However, at least one probable recombinant between two of the major strains was found among the samples originating from Brazil, where mixtures of genotypes co-occur...
  51. ncbi Economic evaluations of varicella vaccination programmes: a review of the literature
    Nancy Thiry
    Department of Epidemiology and Social Medicine, Centre for the Evaluation of Vaccination, University of Antwerp, Antwerp, Belgium
    Pharmacoeconomics 21:13-38. 2003
    b>Chickenpox infections are generally mild but due to their very high incidence among healthy children they give rise to considerable morbidity and occasional mortality...
  52. ncbi VZV T cell-mediated immunity
    Adriana Weinberg
    University of Colorado Denver, Aurora, CO 80045, USA
    Curr Top Microbiol Immunol 342:341-57. 2010
    ..Similarly, the magnitude of these responses early after the onset of herpes zoster correlates with the extent of zoster-associated pain. These essential immune responses are boosted by the VZV vaccine developed to prevent herpes zoster...
  53. ncbi The effectiveness of the varicella vaccine in clinical practice
    M Vazquez
    Department of Pediatrics, Yale University School of Medicine, New Haven, Conn 06520 8064, USA
    N Engl J Med 344:955-60. 2001
    ..A live attenuated varicella vaccine was approved for use in the United States in March 1995 and is recommended for all susceptible persons 12 months of age or older...
  54. pmc Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo
    Stefan L Oliver
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Virol 83:7495-506. 2009
    ..This is the first evidence that cleavage of a herpesvirus fusion protein contributes to viral pathogenesis in vivo, as seen for fusion proteins in other virus families...
  55. pmc Varicella vaccination in England and Wales: cost-utility analysis
    M Brisson
    Immunisation Division, PHLS Communicable Disease Surveillance Centre, London NW9 5EQ, UK
    Arch Dis Child 88:862-9. 2003
    ..To assess the cost-effectiveness of varicella vaccination, taking into account its impact on zoster...
  56. ncbi Safety profile of live varicella virus vaccine (Oka/Merck): five-year results of the European Varicella Zoster Virus Identification Program (EU VZVIP)
    Nicolas Goulleret
    Sanofi Pasteur MSD, Lyon, France
    Vaccine 28:5878-82. 2010
    ..The European VZVIP provides data on VZV clade distribution...
  57. ncbi Varicella-zoster virus neurotropism in SCID mouse-human dorsal root ganglia xenografts
    L Zerboni
    Stanford University Medical Center, Stanford, CA, USA
    Curr Top Microbiol Immunol 342:255-76. 2010
    ..The SCID mouse-human DRG xenograft model may aid in the development of clinical strategies in the management of herpes zoster as well as in the development of "second generation" neuroattenuated vaccines...
  58. ncbi A seroepidemiology study of varicella among children aged 0-12 years in Taiwan
    H F Tseng
    Institute of Medical Research, Chang Jung University, Taiwan
    Southeast Asian J Trop Med Public Health 36:1201-7. 2005
    ..The efforts of implementing a varicella vaccination program in Taiwan should focus on reaching high levels of coverage...
  59. ncbi Varicella vaccination: impact of vaccine efficacy on the epidemiology of VZV
    M Brisson
    Immunisation Division, PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    J Med Virol 70:S31-7. 2003
    ....
  60. ncbi The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccination
    Hester de Melker
    Centre for Infectious Disease Epidemiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:3946-52. 2006
    We studied the epidemiology of varicella (chickenpox) and herpes zoster (shingles) in The Netherlands to assess the desirability to implement routine varicella zoster virus vaccination in The Netherlands...
  61. ncbi A household study of chickenpox in Guinea-Bissau: intensity of exposure is a determinant of severity
    A Poulsen
    Projecto de Saude de Bandim, Guinea Bissau, Denmark
    J Infect 45:237-42. 2002
    To determinate the relative importance of state of nutrition and intensity of exposure for clinical severity of chickenpox in a developing country.
  62. ncbi Seroprevalence of varicella antibodies in healthcare workers and health sciences students. Reliability of self-reported history of varicella
    J R de Juanes
    Preventive Medicine Service, 12 de Octubre University Hospital, Madrid, Spain
    Vaccine 23:1434-6. 2005
    ..4%, 66.7%, 95.4% and 17.2%, respectively. The preferred approach in these groups at risk of varicella will be to undergo serologic testing before immunization in those with negative or unknown history of varicella...
  63. ncbi Breakthrough VZV infection after immunization, presenting as herpes zoster
    Rogier P Schade
    Department of Medical Microbiology, Nijmegen, The Netherlands
    Scand J Infect Dis 40:428-30. 2008
    ..VZV-vaccinated child had a breakthrough infection with VZV, acquired at a day-care centre during a chickenpox outbreak. Interestingly, the infection manifested as herpes zoster of 1 dermatome...
  64. ncbi Challenges to implementing second-dose varicella vaccination during an outbreak in the absence of a routine 2-dose vaccination requirement--Maine, 2006
    Amy A Parker
    Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
    J Infect Dis 197:S101-7. 2008
    ..These findings support ACIP's June 2007 recommendation for a routine 2-dose varicella vaccination program...
  65. ncbi How reliable is the history of chickenpox? Varicella serology among children up to 14 years of age
    J Kavaliotis
    Department of Pediatrics, Hospital for Infectious Diseases, Thessaloniki, Greece
    Int J Infect Dis 7:274-7. 2003
    ..The aim of this study was to assess the seroprevalence of antibodies to varicella-zoster virus (VZV) in children of northern Greece and to estimate the reliability of varicella history...
  66. ncbi An increasing incidence of chickenpox central nervous system complications in children: what's happening in Tuscany?
    Stefano Frenos
    Department of Pediatrics, University of Florence, Anna Meyer Children s Hospital, Via Luca Giordano, 13, I 50132 Florence, Italy
    J Clin Virol 38:358-61. 2007
    The most frequent noncutaneous site of involvement of chickenpox is the central nervous system (CNS) and complications include cerebellar ataxia, encephalitis, and meningitis.
  67. pmc Varicella-zoster virus proteins in skin lesions: implications for a novel role of ORF29p in chickenpox
    P W Annunziato
    Departments of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Virol 74:2005-10. 2000
    ..ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts...
  68. ncbi Reactions of pediatricians to the recommendation for universal varicella vaccination
    R D Newman
    Department of Pediatrics, University of Washington School of Medicine, Children s Hospital and Medical Center, Seattle, USA
    Arch Pediatr Adolesc Med 152:792-6. 1998
    ....
  69. ncbi Use of combination measles, mumps, rubella, and varicella vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP)
    Mona Marin
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-12. 2010
    ..cdc.gov/vaccines/recs/provisional/downloads/combo-vax-Aug2009-508.pdf), which state that use of a combination vaccine generally is preferred over its equivalent component vaccines...
  70. pmc Varicella vaccination during early pregnancy: a cause of in utero miliary fetal tissue calcifications and hydrops?
    Joseph Apuzzio
    Department of Obstetrics, Gynecology and Women s Health, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Infect Dis Obstet Gynecol 10:159-60. 2002
    ....
  71. ncbi Varicella vaccine and shingles
    Marc Brisson
    JAMA 287:2211; author reply 2211-2. 2002
  72. ncbi A new challenge for Europe: introducing a pediatric quadrivalent vaccine for measles, mumps, rubella, and varicella
    Jose Ramet
    Department of Pediatrics, Universitair Ziekenhuis Antwerpen, Antwerp Belgium
    Int J Infect Dis 11:S49-55. 2007
    ..Varicella is often considered to be a benign disease of childhood. In fact, varicella is associated with serious complications and mortality even among healthy individuals...
  73. pmc Simian varicella virus infection of Chinese rhesus macaques produces ganglionic infection in the absence of rash
    Werner J D Ouwendijk
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurovirol 18:91-9. 2012
    Varicella-zoster virus (VZV) causes varicella (chickenpox), becomes latent in ganglia along the entire neuraxis, and may reactivate to cause herpes zoster (shingles)...
  74. pmc Effectiveness of 2 doses of varicella vaccine in children
    Eugene D Shapiro
    Department of Pediatrics, Yale University School of Medicine and Graduate School of Arts and Sciences, New Haven, Connecticut 06520 8064, USA
    J Infect Dis 203:312-5. 2011
    ..Because of ongoing outbreaks of varicella, a second dose of varicella vaccine was added to the routine immunization schedule for children in June 2006 by the Centers for Disease Control and Prevention...
  75. ncbi Exploring the impact of exposure to primary varicella in children on varicella-zoster virus immunity of parents
    Benson Ogunjimi
    Centre for Health Economics Research and Modeling Infectious Diseases CHERMID, University of Antwerp, Antwerp, Belgium
    Viral Immunol 24:151-7. 2011
    ..One year after initial re-exposure to VZV, VZV-immune adults showed a rise in cellular response as assessed by IFN-γ ELISPOT, and steady-state levels for the humoral response...
  76. pmc Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responses
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
    J Infect Dis 201:1024-30. 2010
    ..We studied the relationship between VZV cell-mediated immunity and age after varicella or VZV vaccination in healthy and human immunodeficiency virus (HIV)-infected individuals...
  77. ncbi Seroprevalence of varicella-zoster virus immunoglobulin G antibodies in Swiss adolescents and risk factor analysis for seronegativity
    U Heininger
    University Children s Hospital, Basel, Switzerland
    Pediatr Infect Dis J 20:775-8. 2001
    ..Little is known about the seroprevalence of anti-varicella-zoster virus (VZV) serum antibodies in adolescents in Switzerland as in most other European countries...
  78. ncbi Assessing the introduction of universal varicella vaccination in the Netherlands
    Hein J Boot
    Laboratory of Vaccine Preventable Diseases, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:6288-99. 2006
    ..Despite these uncertainties it is clear that universal childhood vaccination will prevent most of the varicella related GP-visits, hospitalizations, and deaths...
  79. ncbi Fatal outbreak of chickenpox (varicella-zoster virus infection) among institutionalised adults with learning difficulties
    J Noorda
    Department of Infectious Diseases, Western and Eastern South Limburg Municipal Health Service, Heerlen, The Netherlands
    Commun Dis Public Health 7:164-8. 2004
    Most adults are not susceptible to chickenpox. We present a report of an outbreak of chickenpox among institutionalised adults with learning difficulties...
  80. ncbi [Varicella: previously healthy children sometimes develop complications]
    M E Mérelle
    Spaarne Ziekenhuis, afd Kindergeneeskunde, Postbus 770, 2130 AT Hoofddorp
    Ned Tijdschr Geneeskd 150:2625-9. 2006
    ..Last year, a European consensus was published that recommended that all healthy children be vaccinated against chickenpox. In The Netherlands, routine varicella zoster virus (VZV) vaccination has not (yet) been implemented...
  81. ncbi Seroepidemiology of Varicella zoster in Israel prior to large-scale use of varicella vaccines
    D I Cohen
    Department of Epidemiology and Preventive Medicine, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel
    Infection 34:208-13. 2006
    ..This large-scale study provides up-to-date estimates of Varicella zoster virus (VZV) age-specific seroprevalence and characteristics of VZV transmission in a representative sample of the Israeli population...
  82. ncbi The burden of varicella complications before the introduction of routine varicella vaccination in Germany
    Johannes G Liese
    Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Pediatr Infect Dis J 27:119-24. 2008
    ..The true burden of varicella complications in Germany is not known. We investigated the incidence and pattern of varicella complications in children and adolescents using 3 independent surveillance sources...
  83. ncbi Chickenpox and the geniculate ganglion: facial nerve palsy, Ramsay Hunt syndrome and acyclovir treatment
    Charles Grose
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242, USA
    Pediatr Infect Dis J 21:615-7. 2002
    ..The site of reactivation from latency is the geniculate ganglion. Virus most likely enters the ganglion during chickenpox, via the sensory branches of the facial nerve located on the ear and tongue...
  84. pmc Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaques
    Ravi Mahalingam
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Virol 84:12454-7. 2010
    ..Virus transcription and the detection of open reading frame (ORF) 63 protein in the cytoplasm of neurons were comparable. Thus, a 30-h delay after death did not affect varicella-zoster virus expression in latently infected ganglia...
  85. pmc The burden of varicella from a parent's perspective and its societal impact in The Netherlands: an Internet survey
    Judith H Wolleswinkel-van den Bosch
    Pallas, Health Research and Consultancy BV, Rotterdam, The Netherlands
    BMC Infect Dis 11:320. 2011
    ..Most data on the burden of varicella stem from health service databases. This study aims to provide insight in the burden of varicella from a parent's perspective including cases outside the healthcare system...
  86. ncbi Isolated bilateral anterior optic neuritis following chickenpox in an immunocompetent adult
    A Galbussera
    Neurology Section, Department of Neurosciences, University of Milan Bicocca S Gerardo Hospital, Via Donizetti 106, I 20052, Monza MI, Italy
    Neurol Sci 27:278-80. 2006
    b>Chickenpox may lead to several different neurological complications, but optic neuritis has rarely been described; in particular, only one case of isolated bilateral anterior optic neuritis (AON) in an immune-competent adult has so far ..
  87. ncbi Varicella-zoster virus human ganglionic latency: a current summary
    Peter G E Kennedy
    Department of Neurology, Glasgow University, Southern General Hospital, Glasgow, Scotland, UK
    J Neurovirol 16:411-8. 2010
    ..virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for ..
  88. ncbi Hospitalization of newborns and young infants for chickenpox in France
    Aurélie Lécuyer
    Association Clinique et Thérapeutique Infantile du Val de Marne ACTIV, Saint Maur des Fossés, France
    Eur J Pediatr 169:1293-7. 2010
    b>Chickenpox is often considered more severe during the first year of life, but its course is usually mild during the first 3 months of life, presumably owing to the persistence of maternal antibodies...
  89. ncbi [Chickenpox: sufficient reasons for the introduction of vaccination]
    H Rumke
    Vaxinostics Universitair Vaccincentrum Rotterdam Nijmegen, p a Erasmus MC, kamer Ee1931, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 150:2630-2. 2006
    The incidence of chickenpox and its complications is high enough to favour introducing varicella vaccination into the Dutch immunisation programme for children, although current Dutch figures may even underestimate the incidence...
  90. pmc Pyomyositis secondary to chickenpox
    Dhruv Rastogi
    Royal London Hospital, London, UK
    Arch Dis Child 92:871. 2007
  91. ncbi Chickenpox increasingly affects preschool children
    A M Ross
    Commun Dis Public Health 3:213-5. 2000
    Between 1983 and 1998, age specific incidences of chickenpox derived from consultations with general practitioners taking part in the Royal College of General Practitioners Weekly Returns Service doubled in children aged 0 to 4 years, ..
  92. ncbi Susceptibility to infectious rash illness in pregnant women from diverse geographical regions
    S J Knowles
    Department of Microbiology, Rotunda Hospital, Parnell Square, Dublin 1, Ireland
    Commun Dis Public Health 7:344-8. 2004
    ..There are important differences in immunity to these infections and so of potential risk of an adverse outcome in indigenous and immigrant pregnant women in Ireland...
  93. ncbi Immigration flows and new epidemiological evidence in southern Italy
    Giovanni Gabutti
    Department of Biological and Environmental Sciences and Technologies DiSTeBA, University of Lecce, Via provinciale Lecce Monteroni, 73100 Lecce, Italy
    Vaccine 21:399-400. 2003
    ..Recently, 55 chickenpox cases were reported among Sri Lankan immigrants, four cases among subjects already sheltered in the centres who ..
  94. ncbi Strategies to prevent varicella among newly arrived adult immigrants and refugees: a cost-effectiveness analysis
    Patrick Merrett
    Respiratory Division and Respiratory Epidemiology Unit, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Clin Infect Dis 44:1040-8. 2007
  95. ncbi Chickenpox: presentation and complications in adults
    Ali Hassan Abro
    Infectious Diseases Unit, Rashid Hospital Dubai, United Arab Emirates
    J Pak Med Assoc 59:828-31. 2009
    To describe the clinical manifestations laboratory findings and frequency of complications in adult chickenpox patients admitted in the hospital.
  96. ncbi Risk factors and outcome of varicella-zoster virus pneumonia in pregnant women
    James H Harger
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3180, USA
    J Infect Dis 185:422-7. 2002
    ..6-16.7) and to have > or = 100 skin lesions (OR, 15.9; 95% CI, 1.9-130.2). Pregnant women with VZV infection may be more likely to develop varicella pneumonia if they are smokers or manifest > or = 100 skin lesions...
  97. ncbi Seroprevalence of measles, rubella, and varicella in refugees
    Elizabeth D Barnett
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, MA 02118, USA
    Clin Infect Dis 35:403-8. 2002
    ..Antibody to all 3 diseases increased with increasing age. No clinically significant differences in presence of antibody were noted by region of origin...
  98. ncbi Risk factors for chickenpox incidence in Taiwan from a large-scale computerized database
    Po Yuan Wu
    Graduate Institute of Medical Informatics, Taipei Medical University, Guangyan Dermatology Clinic, School of Public Health, China Medical University, Taipei, Taiwan
    Int J Dermatol 46:362-6. 2007
    We analyzed data from the National Health Insurance Research (NHIR) database in the year 2000 to estimate the seasonal variation in the chickenpox rate in Taiwan.
  99. pmc Epidemiological game-theory dynamics of chickenpox vaccination in the USA and Israel
    Jingzhou Liu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J R Soc Interface 9:68-76. 2012
    ..However, diseases that become more severe with age, such as chickenpox, pose an exception to this general consensus...
  100. ncbi Growth, morbidity and mortality after chickenpox infection in young children in Guinea-Bissau
    Anja Poulsen
    Projecto de Saude de Bandim, Guinea Bissau, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Infect 51:307-13. 2005
    To examine whether chickenpox in children below 2 years of age is associated with post-infection changes in growth, morbidity or mortality.
  101. ncbi Outbreak of varicella at a day-care center despite vaccination
    Karin Galil
    Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 347:1909-15. 2002
    ..We investigated an outbreak of varicella in a population of children with a high proportion of vaccinees who were attending a day-care center in a small community in New Hampshire...

Research Grants62

  1. ROLE OF VARICELLA ZOSTER VIRUS GLYCOPROTEIN B DURING VIR
    THOMAS HEINEMAN; Fiscal Year: 2003
    Herpesviruses are responsible for several human diseases including chickenpox, shingles, oral and genital herpes, and life-threatening infections in persons with weakened immune systems...
  2. Varicella zoster virus: molecular controls of cell fusion-dependent pathogenesis
    Ann Arvin; Fiscal Year: 2013
    ..Varicella-zoster virus (VZV) is a medically important human [unreadable]-herpesvirus that causes varicella (chickenpox) and leads to zoster (shingles) upon reactivation from latently infected sensory ganglia...
  3. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..The highly innovative aspect of this proposal is the potential for developing safe subunit vaccines that are as immunogenic as live vaccines in stimulating cell-mediated immunity against intracellular pathogens of humans. ..
  4. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..Poliomyelitis, mumps, measles, rubella, and chickenpox are prevented with childhood vaccines that contain live, replicating viruses that occur in nature, but are ..
  5. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ....
  6. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ....
  7. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Varicella zoster virus (VZV) causes chickenpox, after which the virus becomes latent in cranial nerve, dorsal root and autonomic nervous system ganglia along the entire neuraxis...
  8. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ....
  9. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    ..virus (VZV), reactivates from a latent state that was established in the host sensory neurons during chickenpox. While viral replication induces nerve damage and inflammation to initiate pain, the mechanisms by which VZV ..
  10. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..abstract_text> ..
  11. Prevention of VZV Reactivation
    Randall J Cohrs; Fiscal Year: 2013
    ..by applicant): Varicella zoster virus (VZV), a ubiquitous neurotropic alphaherpesvirus that causes varicella (chickenpox), becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis...
  12. The molecular pathogenesis of varicella zoster virus infection
    Donald Gilden; Fiscal Year: 2013
    ..Primary infection by varicella zoster virus (VZV) usually causes varicella (chickenpox), after which virus becomes latent in human ganglionic neurons along the entire neuraxis...
  13. Genome packaging in DNA viruses
    Liang Tang; Fiscal Year: 2013
    ..Herpes viruses are important human pathogens that cause diseases ranging from chickenpox to various forms of cancer...
  14. MECHANISMS OF DNA REPLICATION AND RECOMBINATION IN HSV-1
    Paul E Boehmer; Fiscal Year: 2010
    ..They will also increase our overall knowledge of fundamental mechanisms in replication and recombination. ..
  15. Real-time detection and identification of single viruses
    Lukas Novotny; Fiscal Year: 2011
    ..Viruses are responsible for a considerable number of human diseases such as chickenpox or the common flu. In some cases (Ebola, AIDS, SARS,) viral pathogens result in serious disease or even death...
  16. Structure/Function of Varicella Zoster Virus DNA.
    William Ruyechan; Fiscal Year: 2009
    ..S. population it is important to understand how the virus interacts with its human host. This work should also result in information that could be used in strategies to develop better anti-viral drugs and vaccines. ..
  17. SEVENTEENTH INTERNATIONAL HERPESVIRUS WORKSHOP
    S Hayward; Fiscal Year: 1992
    ....
  18. The Role of Infection in Childhood Stroke
    Heather J Fullerton; Fiscal Year: 2010
    ..Understanding why strokes occur in children is the first step towards designing effective methods of preventing stroke. ..
  19. 26th Intl Herpesvirus Workshop, Regensburg, Germany
    Jay Nelson; Fiscal Year: 2001
    ..entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy, ..
  20. International Herpesvirus Workshop, Cairns, Australia
    Jay Nelson; Fiscal Year: 2002
    ..abstract_text> ..
  21. 25TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay Nelson; Fiscal Year: 2000
    ....
  22. EIGHTEENTH INTERNATIONAL HERPES VIRUS MEETING
    Joseph Glorioso; Fiscal Year: 1993
    ....
  23. 24TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Frederick Wang; Fiscal Year: 1999
    ..abstract_text> ..
  24. 15TH INTERNATIONAL HERPESVIRUS WORKSHOP
    LEONARD ROSENTHAL; Fiscal Year: 1990
    ..The topics include: gene regulation, latency and pathogenesis, immunology, neoplasia, replication, glycoproteins and structural proteins, enzymes and nonstructural proteins, and AIDS and herpesviruses...
  25. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
    Varicella zoster virus (VZV) causes chickenpox (varicella) and shingles (herpes zoster)...
  26. VZV Receptors & Infective Mechanisms
    Anne Gershon; Fiscal Year: 2001
    Varicella zoster virus (VZV), the cause of varicella (chickenpox) and zoster (shingles), is highly infectious but, paradoxically, spreads only by cell-to-cell contact in vitro...
  27. Fourth International Conference--Varicella Zoster Virus
    Anne Gershon; Fiscal Year: 2001
    ..The meeting is planned to occur March 3-5, 2001 in LaJolla, CA. VZV is the agent that causes varicella (chickenpox) and zoster (shingles), both of which are important pathogens for humans...
  28. Molecular mechanisms of gammaherpesvirus latency and reactivation
    Douglas White; Fiscal Year: 2009
    ..This research aims to understand, at a molecular level, how herpesviruses maintain latency and reactivate to cause disease. ..
  29. Ecology and Evolution of Disease Interference
    Pejman Rohani; Fiscal Year: 2007
    ..spatio-temporal data-sets, much of this work will focus on childhood infections (eg as measles, pertussis, chickenpox and rubella), though the proposed mechanism is quite general...
  30. EGFP-Tagged VZV for the Study of Neuronal Infection
    THOMAS HEINEMAN; Fiscal Year: 2006
    Varicella-zoster virus (VZV) is a member of the herpesvirus family. Infection with VZV causes chickenpox, which typically resolves on its own...
  31. SIMIAN VARICELLA MODEL FOR HUMAN VZV INFECTIONS
    WAYNE GRAY; Fiscal Year: 1992
    Varicella-zoster virus (VZV) is the etiologic agent of varicella (chickenpox) and zoster (shingles)...
  32. GENE REGULATION BY VARICELLA ZOSTER VIRUS 140K. PROTEIN
    JOAN BETZ; Fiscal Year: 1992
    ....
  33. Role of gM and gE in herpesvirus infection of neurons
    LISA POMERANZ; Fiscal Year: 2004
    ..herpes simplex virus type-1 (HSV-l) and -2 (HSV-2) and varicella zoster virus (VZV), the causative agent of chickenpox. Subsequent to lytic infection of the host's epithelial tissue, alphaherpesviruses establish a reactivatable ..
  34. SIMIAN VARICELLA--VZV PATHOGENESIS & LATENCY
    WAYNE GRAY; Fiscal Year: 2000
    DESCRIPTION (Adapted from Applicant's Abstract): Varicella zoster virus (VZV) causes varicella (chickenpox) and zoster (shingles), diseases associated with significant morbidity in children and the elderly, respectively, and severe and ..
  35. Structure/Function of Varicella Zoster Virus DNA
    William Ruyechan; Fiscal Year: 2002
    ..VZV) is a ubiquitous human alphaherpesvirus, which is the infectious agent of two diseases, causing varicella (chickenpox) during primary infection and zoster (shingles) after reactivation from latency...
  36. VARICELLA-ZOSTER VIRUS MEMBRANE ANTIGENS
    CLARK EDSON; Fiscal Year: 1992
    ..virus (VZV) is s neurotropic human herpesvirus that causes two clinically distinct diseases: varicella (chickenpox) and zoster (shingles)...
  37. VARICELLA ZOSTER VIRUS PATHOGENESIS
    John Hay; Fiscal Year: 2001
    Varicella zoster virus (VZV) is a ubiquitous human herpesvirus and is the infectious agent of chickenpox (varicella) and shingles (zoster). Both varicella and, particularly, zoster continue to be health problems...
  38. Synergistic infection by varicella and streptococci
    Colette Cywes Bentley; Fiscal Year: 2004
    ..infection is increased by approximately 50-fold in children with primary varicella zoster virus (VZV) infection (chickenpox)...
  39. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Varicella zoster virus (VZV), the cause of varicella (chickenpox) and zoster (shingles), is highly infectious but spreads only by cell-to-cell contact in vitro...
  40. PEDIATRICS AIDS CLINICAL TRIALS GROUP
    Anne Gershon; Fiscal Year: 2006
    ..We have competent, outstanding staff whose aim is not only to provide compassionate medical care to HIV-infected patients but also to perform meaningful and useful research on prevention and treatment of HIV infection. ..
  41. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  42. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    Varicella zoster virus (VZV) causes varicella (chickenpox), a common disease of childhood. Following resolution of the acute disease, VZV establishes latent infection in neural ganglia...
  43. Assessing Functional Outcomes in Adolescent with ESRD
    Susan Furth; Fiscal Year: 2002
    ..This experience will give Dr. Furth the tools she needs to develop into an independent clinical investigator in a nurturing academic environment. ..
  44. Clinical Performance Measures & Outcomes in Adolescents
    Susan Furth; Fiscal Year: 2005
    ..abstract_text> ..
  45. METHYLPHENIDATE TREATMENT AND PRENATAL ALCOHOL EXPOSURE
    SARAH MATTSON; Fiscal Year: 2002
    ..Knowledge gained from this research will help to provide a more rational basis for the treatment of the well-documented attentional problems in these children. ..
  46. DETERMINING/UNDERSTANDING BARRIERS TO ADULT IMMUNIZATION
    Richard Zimmerman; Fiscal Year: 2001
    ..This project will furnish relevant, up-to-date to enhance policy planning, practice management and medical education. ..
  47. Using MEPS Data to Inform Public-Plan Consumerism
    Matthew Davis; Fiscal Year: 2007
    ..Findings will have immediate relevance for implementation of the HOA projects and other consumerism efforts. [unreadable] [unreadable] [unreadable]..
  48. Fetal Alcohol Syndrome: Neuropsychological Assessment of Children
    SARAH MATTSON; Fiscal Year: 2007
    ..Clarification of these dissociations will help define the profile of weaknesses and strengths in children with heavy prenatal alcohol exposure and help identify core deficits in this population. ..
  49. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Varicella-zoster virus (VZV) is the cause of chickenpox and herpes zoster. VZV infection is a recurrent problem in both transplant and cancer patients...
  50. ASSESSING PATIENT OUTCOMES IN PEDIATRIC ESRD
    Susan Furth; Fiscal Year: 2003
    ..Furth the tools she needs to develop into an independent clinical investigator in a nurturing academic environment. ..
  51. A RANDOMIZED CONTROLLED TRIAL OF ECHINACEA IN CHILDREN
    James Taylor; Fiscal Year: 2001
    ..abstract_text> ..
  52. THE EFFECTIVENESS OF VACCINES IN CLINICAL PRACTICE
    Eugene Shapiro; Fiscal Year: 2004
    ..Shapiro to review their progress and to help them develop their own studies as well as to develop strategies for the development of their careers. ..
  53. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
    ..The results will be important for immunodeficient humans chronically infected with the parasite. ..
  54. Effectiveness of Varicella Vaccine in Clinical Practice
    Eugene Shapiro; Fiscal Year: 2006
    ..abstract_text> ..
  55. Training in Patient-Oriented Research for Physicians
    Eugene Shapiro; Fiscal Year: 2006
    ..Ultimately, the Yale CRS Program will help to increase the pool of physician-investigators who will be uniquely poised to conduct research to directly improve the health of all Americans. [unreadable] [unreadable] [unreadable]..
  56. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..Thus, patients who can tolerate higher doses of chemotherapy can be treated more efficiently, suffering from less side effects and potentially may have a better outcome. ..
  57. ADULT AIDS CLINICAL TRIALS UNIT
    HENRY BALFOUR; Fiscal Year: 2008
    ..The Iowa subunit has expertise in detection of hepatitis C and will be collaborating in studies of the pathogenesis of coinfection with HIV and hepatitis C. ..
  58. MOLECULAR EPIDEMIOLOGY OF GLIOMAS
    Melissa Bondy; Fiscal Year: 2004
    ..no abstract available ..
  59. IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS
    BARRY ROUSE; Fiscal Year: 2005
    ..Our experiments may identify better methods of generating protective immunity against HSV. ..
  60. VACCINATION AGAINST HERPES SIMPLEX VIRUS
    BARRY ROUSE; Fiscal Year: 2004
    ..Our results should be applicable to the future design of vaccines against HSV and may have application to other situations that require immunomodulation. ..
  61. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
    ..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..