herpesviridae infections

Summary

Summary: Virus diseases caused by the HERPESVIRIDAE.

Top Publications

  1. pmc Viral latency and its regulation: lessons from the gamma-herpesviruses
    Samuel H Speck
    Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
    Cell Host Microbe 8:100-15. 2010
  2. ncbi Pathogenesis and host control of gammaherpesviruses: lessons from the mouse
    Erik Barton
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Annu Rev Immunol 29:351-97. 2011
  3. ncbi Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection
    Sophie Sierro
    The Peter Medawar Building for Pathogen Research, Oxford, UK
    Eur J Immunol 35:1113-23. 2005
  4. pmc Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein
    Christopher M Collins
    Emory Vaccine Center, Atlanta, Georgia 30322, USA
    J Virol 83:6484-93. 2009
  5. pmc Recognition of herpesviruses by the innate immune system
    Søren R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    Nat Rev Immunol 11:143-54. 2011
  6. pmc Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:7125-32. 2002
  7. ncbi Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection
    Nicolas Zucchini
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy, Marseille Cedex 09, France
    J Immunol 180:5799-803. 2008
  8. pmc Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis
    Fu Chun Zhou
    Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Virol 76:6185-96. 2002
  9. ncbi Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection
    Michael W Munks
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Immunol 177:450-8. 2006
  10. pmc Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt"
    Sheila C Dollard
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Int J Cancer 127:2395-401. 2010

Research Grants

Detail Information

Publications329 found, 100 shown here

  1. pmc Viral latency and its regulation: lessons from the gamma-herpesviruses
    Samuel H Speck
    Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
    Cell Host Microbe 8:100-15. 2010
    ..Here, we review the molecular basis of latency, with special attention to the gamma-herpesviruses, in which the understanding of this process is most advanced...
  2. ncbi Pathogenesis and host control of gammaherpesviruses: lessons from the mouse
    Erik Barton
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Annu Rev Immunol 29:351-97. 2011
    ..MHV68 represents a unique model to define the effects of chronic viral infection on the antiviral immune response...
  3. ncbi Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection
    Sophie Sierro
    The Peter Medawar Building for Pathogen Research, Oxford, UK
    Eur J Immunol 35:1113-23. 2005
    ..A simple model to describe the equilibrium state in MCMV is presented, which may point to previously unexplored antiviral populations present after human CMV infection...
  4. pmc Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein
    Christopher M Collins
    Emory Vaccine Center, Atlanta, Georgia 30322, USA
    J Virol 83:6484-93. 2009
    ....
  5. pmc Recognition of herpesviruses by the innate immune system
    Søren R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    Nat Rev Immunol 11:143-54. 2011
    ....
  6. pmc Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:7125-32. 2002
    ..The immune system therefore controls chronic gammaherpesvirus infection by site-specific mechanisms that regulate both the number and reactivation phenotype of latently infected cells...
  7. ncbi Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection
    Nicolas Zucchini
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy, Marseille Cedex 09, France
    J Immunol 180:5799-803. 2008
    ..This is the first demonstration of the implication of TLR7 in the recognition of a DNA virus...
  8. pmc Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis
    Fu Chun Zhou
    Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Virol 76:6185-96. 2002
    ..The feasibility of the system was illustrated through the generation of a KSHV mutant with the vIRF gene deleted. This cellular model is useful for the investigation of KSHV infection and pathogenesis...
  9. ncbi Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection
    Michael W Munks
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Immunol 177:450-8. 2006
    ..We suggest that immunological choices are superimposed on altered viral gene expression profiles to determine immunodominance during chronic murine CMV infection...
  10. pmc Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt"
    Sheila C Dollard
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Int J Cancer 127:2395-401. 2010
    ..These findings help to explain the high KS incidence in the "KS Belt" and underscore the importance of a uniform approach to HHV-8 antibody testing...
  11. ncbi Herpesvirus latency confers symbiotic protection from bacterial infection
    Erik S Barton
    Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 447:326-9. 2007
    ..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host...
  12. pmc Early events in Kaposi's sarcoma-associated herpesvirus infection of target cells
    Bala Chandran
    H M Bligh Cancer Research Laboratories, Dept of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Virol 84:2188-99. 2010
    ..The various signaling events triggered by infection, and their potential roles in the different stages of infection and disease pathogenesis, are summarized...
  13. pmc Murine cytomegalovirus encodes a stable intron that facilitates persistent replication in the mouse
    Caroline A Kulesza
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 103:18302-7. 2006
    ..e., little virus was detected in the salivary gland at 14 days after infection. The intron functions as an in vivo virulence factor, facilitating progression from the acute to persistent phase of infection...
  14. ncbi Equine herpesvirus-1 consensus statement
    D P Lunn
    Department of Clinical Sciences, James L Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1620, USA
    J Vet Intern Med 23:450-61. 2009
    ..This consensus statement draws together current knowledge in the areas of pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment...
  15. pmc The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3
    Yanxing Yu
    Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB1 3M09, Baltimore, MD 21231, USA
    Immunity 33:863-77. 2010
    ..These results unveil a previously unrecognized "brake mechanism" for type I IFN that maintains proper low amounts of type I IFN under physiological conditions and restrains its magnitude when the antiviral response intensifies...
  16. pmc IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
    Maria A Stacey
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
    J Immunol 187:2944-52. 2011
    ..Therefore, we conclude that IL-10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in NK cells...
  17. pmc Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis
    Yi Wei Tang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 41:2633-40. 2003
    ..05). Immunohistochemistry for EBV or HHV-8 antigen showed viral antigen primarily in airway epithelial cells. These data support the concept that a herpesvirus could be a source of chronic antigenic stimulation in IPF...
  18. pmc Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission
    Lisa M Butler
    University of California, San Francisco, 50 Beale St, Suite 120, San Francisco, California 94105, USA
    J Infect Dis 200:430-8. 2009
    ..However, few studies have directly examined children, particularly in locations where KS is not commonly endemic...
  19. pmc Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo
    Seungmin Hwang
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Virol 82:12498-509. 2008
    ....
  20. pmc Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response
    Seungmin Hwang
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Host Microbe 5:166-78. 2009
    ..Our data suggest that herpesviruses have evolved within their conserved kinase an anti-IFN activity critical for evasion of host immunity and for persistence...
  21. pmc KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo
    William Wu
    Department of Microbiology and Immunology, State University New York SUNY Upstate Medical University, Syracuse, NY, USA
    Blood 108:141-51. 2006
    ..CD34+ HPCs may be a reservoir for KSHV infection and may provide a continuous source of virally infected cells in vivo...
  22. ncbi Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4
    P G Stevenson
    Division of Virology, Department of Pathology, University of Cambridge, UK
    J Gen Virol 90:2317-30. 2009
    ..Reducing the infectivity of herpesvirus carriers in this way could be a useful adjunct to vaccinating naive individuals with attenuated mutants...
  23. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  24. ncbi The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors
    Hoe Nam Leong
    Division of Infection and Immunity, Centre for Virology, Hampstead Campus, Royal Free and University College Medical School, London, UK
    J Med Virol 79:45-51. 2007
    ..8% of UK blood donors. The presence of high HHV-6 viral loads in healthy normal individuals reiterates the need to consider the confounding effect of HHV-6 viral integration in any laboratory diagnosis of HHV-6 infection...
  25. pmc Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients
    Ethel Cesarman
    Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Cancer Lett 305:163-74. 2011
    ..Understanding the specific viral associations in selected lymphoproliferative disorders, and the insights into the molecular mechanisms of viral oncogenesis, will lead to better treatments for these frequently devastating diseases...
  26. ncbi Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
    C Boshoff
    Virology Laboratory, Royal Marsden Hospital, London, UK
    Nat Med 1:1274-8. 1995
    ..These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions...
  27. pmc Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response
    Agnieszka Kielczewska
    Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada
    J Exp Med 206:515-23. 2009
    ..These findings reveal a novel mechanism of major histocompatibility complex class I-restricted recognition of virally infected cells by an activating NK cell receptor...
  28. pmc The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin
    B Costes
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Virol 83:2819-30. 2009
    ..All the data obtained in the present study demonstrate that the skin, and not the gills, is the major portal of entry for KHV in carp...
  29. pmc CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation
    Christian O Simon
    Institute for Virology, Johannes Gutenberg University, Hochhaus am Augustusplatz, 55101 Mainz, Germany
    J Virol 80:10436-56. 2006
    ..The perpetual gene expression and antigen presentation might represent the driving molecular force in CMV-associated immunosenescence...
  30. ncbi Chromatinisation of herpesvirus genomes
    Christina Paulus
    Institute for Medical Microbiology and Hygiene, University of Regensburg, 93053 Regensburg, Germany
    Rev Med Virol 20:34-50. 2010
    ....
  31. pmc Cytomegalovirus CC chemokine promotes immune cell migration
    Jennifer Vomaske
    Portland Veterans Affairs Medical Center, Portland, Oregon, USA
    J Virol 86:11833-44. 2012
    ..Together our findings indicate that RCMV r129 is highly chemotactic, which has important implications during RCMV infection and reactivation and acceleration of TVS...
  32. pmc Myeloid infection links epithelial and B cell tropisms of Murid Herpesvirus-4
    Bruno Frederico
    Division of Virology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom
    PLoS Pathog 8:e1002935. 2012
    ..These data identify new complexity in rhadinovirus infection and potentially also new vulnerability to intervention...
  33. ncbi Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-saharan africans
    Eugene Sobngwi
    Department of Endocrinology and Diabetes, Saint Louis University Hospital, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    JAMA 299:2770-6. 2008
    ..Its sudden onset suggests precipitating factors...
  34. pmc Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes
    Lisa P Daley-Bauer
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunity 37:122-33. 2012
    ....
  35. pmc Immune modulation during latent herpesvirus infection
    Douglas W White
    Division of Rheumatology, Gundersen Lutheran Medical Center, La Crosse, WI, USA
    Immunol Rev 245:189-208. 2012
    ..The realization that latent herpesvirus infection modulates immune responses in asymptomatic hosts forces us to reconsider what constitutes a 'normal' immune system in a healthy individual...
  36. ncbi Outcome of bovine herpesvirus 4 infection following direct viral injection in the lateral ventricle of the mouse brain
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, Via del Taglio 8, 43100 Parma, Italy
    Microbes Infect 8:898-904. 2006
    ....
  37. pmc Immune senescence: relative contributions of age and cytomegalovirus infection
    Andrea Mekker
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    PLoS Pathog 8:e1002850. 2012
    ..In summary, our results directly demonstrate in a mouse model that latent CMV-infection impairs immunity in old age and propagates immune senescence...
  38. pmc Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis
    Veronika Pozharskaya
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7559. 2009
    ..We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist...
  39. pmc Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells
    Jinjong Myoung
    Howard Hughes Medical Institute, Departments of Microbiology and Medicine and GW Hooper Foundation, University of California, San Francisco, CA 94143, USA
    Virology 413:1-11. 2011
    ..These results affirm the feasibility of studying KSHV infection in primary lymphoid cells, and help to rationalize the detection of KSHV DNA in rare human T cell lymphomas in vivo...
  40. ncbi Escape of herpesviruses from the nucleus
    Chung Pei Lee
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Rev Med Virol 20:214-30. 2010
    ....
  41. ncbi The r131 gene of rat cytomegalovirus encodes a proinflammatory CC chemokine homolog which is essential for the production of infectious virus in the salivary glands
    Suzanne J F Kaptein
    Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 5800, 6202 AZ, The Netherlands
    Virus Genes 29:43-61. 2004
    ..In addition, our data indicate that r131 represents the functional homolog of the MCMV m131/129 gene...
  42. ncbi Equine multinodular pulmonary fibrosis: a newly recognized herpesvirus-associated fibrotic lung disease
    K J Williams
    College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 44:849-62. 2007
    ..Further, we propose that this newly described disease develops in association with infection by the equine gamma-herpesvirus, EHV-5...
  43. ncbi A seroprevalence study of human herpesvirus type 8 (HHV8) in eastern and Central Africa and in the Mediterranean area
    D Serraino
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, IRCCS, Rome, Italy
    Eur J Epidemiol 17:871-6. 2001
    ..The high prevalence of HHV8 infection in newborns, children and adolescents in Egypt, in eastern and in Central Africa strongly suggests the existence of transmission modes other than sexual...
  44. ncbi Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population
    F Frantzidou
    A Department of Microbiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Neurol 15:995-7. 2008
    ..The aim of the study was to identify the etiology and determine the frequency of aseptic meningitis and encephalitis due to HHVs and EVs in an immunocompetent adult population...
  45. pmc Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivo
    Xue Feng Liu
    Transplant Center, Northwestern Memorial Hospital, 675 N St Clair St, Galter Pavilion, Suite 17 200, Chicago, IL 60611, USA
    J Virol 84:3631-43. 2010
    ..The observation that repressors are bound to the MIEP and other promoters immediately upon infection suggests that latency may be established in some cells very early in infection...
  46. pmc Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations
    Kathleen A Stuller
    Center for Vaccines and Immunity, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    J Immunol 184:3850-6. 2010
    ..Our results support the concept that CD4 T cells are critical effectors for the control of gamma-herpesvirus latent infection, and they mediate this effect by two independent mechanisms: IFN-gamma production and cytotoxicity...
  47. pmc Involvement of TLR2 in recognition of acute gammaherpesvirus-68 infection
    François Michaud
    Laboratory of Innate Immunology, Centre Hospitalier Universitaire de Québec Research Center and Department of Molecular Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada
    PLoS ONE 5:e13742. 2010
    ..Because murine gammaherpesvirus-68 (MHV-68) is a useful model to study human gammaherpesvirus pathogenesis in vivo, we evaluated the importance of mouse TLR2 in the recognition of MHV-68...
  48. pmc CD4 T cell immunity is critical for the control of simian varicella virus infection in a nonhuman primate model of VZV infection
    Kristen Haberthur
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Pathog 7:e1002367. 2011
    ....
  49. ncbi Primary effusion lymphoma
    Yi Bin Chen
    Dana Faber Cancer Institute, Boston, Massachusetts, USA
    Oncologist 12:569-76. 2007
    ..The prognosis for PEL is poor, with a median survival time of around 6 months. As the exact molecular steps in HHV-8-driven oncogenesis are unraveled, it is hoped that more specific therapeutic targets will be revealed...
  50. pmc Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virus
    Michael J Molloy
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 186:6218-26. 2011
    ..These data implicate IL-10 as a promising target for the restoration of immune surveillance against chronic γ-herpesvirus infection in immunosuppressed individuals...
  51. pmc Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus
    Tracy R McMillan
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Crit Care Med 177:771-80. 2008
    ..In some cases, acute deterioration is associated with infection. Herpesviruses have been associated with this disease. Fibrocytes have also been shown to be important in the pathogenesis of pulmonary fibrosis...
  52. ncbi Viral coinfections among African children infected with human immunodeficiency virus type 1
    Rana Chakraborty
    Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    Clin Infect Dis 36:922-4. 2003
    ..A protective role for hepatitis G virus cannot be excluded but likely affects only a minority of HIV-1-infected African children...
  53. ncbi DNA viruses (CMV, EBV, and the herpesviruses)
    Martin R Zamora
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver Health Sciences Center, Aurora, Colorado 80045, USA
    Semin Respir Crit Care Med 32:454-70. 2011
    ....
  54. ncbi DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Immunol 176:1741-9. 2006
    ..We propose that DC-SIGN serves as a portal for immune dysfunction and oncogenesis caused by HHV-8 infection...
  55. ncbi The pathogenicity of cytomegalovirus
    C Sweet
    School of Biological Sciences, University of Birmingham, UK
    FEMS Microbiol Rev 23:457-82. 1999
    ..Current information on the role of cytomegalovirus genes in tissue tropism, immune evasion, latency, reactivation from latency and damage is described...
  56. ncbi Biology of bovine herpesvirus 5
    María P Del Médico Zajac
    Virology Institute, Veterinary and Agricultural Science Research Centre, National Institute of Agricultural Technology, N Repeto y Los Reseros S N, Cc25 B1712WAA, Castelar, Buenos Aires, Argentina
    Vet J 184:138-45. 2010
    ..This review focuses on the genomic characteristics, pathobiology and epidemiology of BoHV-5, in order to provide information on the possible basis of alphaherpesvirus neuropathogenesis...
  57. ncbi Phylogenetic comparison of the carboxy-terminal region of glycoprotein C (gC) of bovine herpesviruses (BoHV) 1.1, 1.2 and 5 from South America (SA)
    P A Esteves
    Embrapa Suinos e Aves, BR 153, Km 110, CEP 89700 000, Concordia, SC, Brazil
    Virus Res 131:16-22. 2008
    ..1, BoHV-1.2 and BoHV-5 after phylogenetic analysis. The results suggest that the phylogenetic analysis performed here can be used as a potential molecular epidemiological tool for herpesviruses...
  58. pmc Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract
    Michael B Gill
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Virol 84:10937-42. 2010
    ..RNR could therefore provide a good target for gammaherpesvirus chemotherapy...
  59. ncbi Development of a multiplex polymerase chain reaction for the differentiation of bovine herpesvirus-1 and -5
    M Alegre
    , , , Moron, Argentina
    J Vet Med B Infect Dis Vet Public Health 48:613-21. 2001
    ....
  60. ncbi BHV-1 vaccine induces cross-protection against BHV-5 disease in cattle
    M P Del Médico Zajac
    Instituto de Virologia, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas CICVyA, Instituto Nacional de Tecnologia, Agropecuaria INTA, Castelar, CC77, 1708 Moron, Argentina
    Res Vet Sci 81:327-34. 2006
    ....
  61. pmc Equine herpesvirus 1 enters cells by two different pathways, and infection requires the activation of the cellular kinase ROCK1
    Arthur R Frampton
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Virol 81:10879-89. 2007
    ..These results show that EHV-1 can enter disparate cell types by at least two distinct mechanisms and that productive infection is dependent upon the activation of ROCK1...
  62. ncbi The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells
    G Campadelli-Fiume
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Rev Med Virol 10:305-19. 2000
    ..This provides the first example of a mediator of HSV entry independent of a detectable interaction with gD...
  63. pmc Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses
    Tadahiro Suenaga
    Department of Immunochemistry, Research Institute for Microbial Diseases and WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:866-71. 2010
    ..MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is involved in VZV and HSV infection of neural tissues...
  64. pmc Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 204:1217-25. 2007
    ..Collectively, the results indicate that modulating effector T cell differentiation can counteract pathogen exploitation of the mucosa, thus limiting persistent virus replication and transmission...
  65. ncbi CD46 is a cellular receptor for human herpesvirus 6
    F Santoro
    Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Cell 99:817-27. 1999
    ..The use of a ubiquitous immunoregulatory receptor opens novel perspectives for understanding the tropism and pathogenicity of HHV-6...
  66. pmc Murid herpesvirus-4 exploits dendritic cells to infect B cells
    Miguel Gaspar
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Pathog 7:e1002346. 2011
    ..In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells...
  67. pmc Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels
    R M Presti
    Center for Immunology, Departments of Pathology and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 188:577-88. 1998
    ..This provides a new model for analysis of the interrelationships among herpesvirus latency, the immune system, and chronic disease of the great vessels...
  68. pmc Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation
    Meagan A Jacoby
    Division of Microbiology and Immunology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Virol 76:1790-801. 2002
    ..These results indicate that the requirements for the establishment of latency are affected by the route of infection...
  69. ncbi The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host
    Torsten Sacher
    Max von Pettenkofer Institute, Ludwig Maximilians University, Munich D 80336, Germany
    Cell Host Microbe 3:263-72. 2008
    ..Thus, the cell type producing the most viruses was not necessarily the one responsible for virus dissemination within the host...
  70. pmc The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response
    Maja Mitrovic
    Department of Histology and Embryology, University of Rijeka, Rijeka, Croatia
    J Virol 86:2165-75. 2012
    ....
  71. pmc A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology
    Andrew G Evans
    Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:669-84. 2008
    ....
  72. ncbi Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice
    Ana L Mora
    Center for Translational Research of the Lung, Division of Pulmonary, Allergy, and Critical Care, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 289:L711-21. 2005
    ..In summary, chronic herpesvirus pulmonary infection in IFN-gammaR-/- mice causes progressive pulmonary fibrosis and many of the pathological features seen in IPF...
  73. pmc Regulation of CD1d expression and function by a herpesvirus infection
    David Jesse Sanchez
    George Williams Hooper Foundation, University of California, San Francisco, 94143, USA
    J Clin Invest 115:1369-78. 2005
    ..KSHV modulation of CD1d expression represents a strategy for viral evasion of innate host immune responses and implicates CD1d-restricted T cells as regulators of this viral infection...
  74. ncbi HIV-associated lymphomas and gamma-herpesviruses
    Antonino Carbone
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy
    Blood 113:1213-24. 2009
    ....
  75. ncbi The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection
    Senta M Walton
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Immunol 181:1128-34. 2008
    ..Furthermore, MCMV-specific CD4 T cells displayed a Th1 phenotype, secreting high levels of IFN-gamma and TNF-alpha and to some extent IL-2, cytokines which are involved in protection from CMV disease...
  76. pmc Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication
    Vera L Tarakanova
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 1:275-86. 2007
    ..Thus, activation of proximal components of the DNA damage signaling response is an active viral kinase-driven strategy required for efficient gamma-herpesvirus replication...
  77. pmc Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response
    Ramon Arens
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:6472-6. 2008
    ..In total, this study reveals that the MCMV-specific CD4 T cell response is complex and functionally diverse, highlighting its important role in controlling this persistent pathogen...
  78. ncbi A mouse model for infectious mononucleosis
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Res 25:201-17. 2002
    ..The focus of this article will be to highlight the similarities and differences in the infectious mononucleosis syndrome associated with human and murine gamma-herpesviruses...
  79. ncbi Batf3 transcription factor-dependent DC subsets in murine CMV infection: differential impact on T-cell priming and memory inflation
    Nicole Torti
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 41:2612-8. 2011
    ..These results highlight differential antigen presentation requirements during acute and latent MCMV infection...
  80. pmc Latent herpesvirus infection augments experimental pulmonary fibrosis
    Kevin M Vannella
    Graduate Program in Immunology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 181:465-77. 2010
    ..Accumulating evidence implicates herpesviruses as cofactors (either initiating or exacerbating agents) of fibrotic lung disease, but a role for latent herpesvirus infection has not been studied...
  81. pmc Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans
    Ilhem Messaoudi
    Vaccine and Gene Therapy, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, United States of America
    PLoS Pathog 5:e1000657. 2009
    ..Intrabronchial inoculation of rhesus macaques with SVV provides a novel model to analyze viral and immunological mechanisms of VZV latency and reactivation...
  82. ncbi Immune control of herpes simplex virus during latency
    Kamal M Khanna
    Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213 2588, USA
    Curr Opin Immunol 16:463-9. 2004
    ....
  83. pmc Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
    Hongyu Deng
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 90095, USA
    J Virol 76:8252-64. 2002
    ..We propose that the existence of two vIL-6 promoters offers opportunities for differential regulation of vIL-6 gene expression in different tissue types and may account for the variable vIL-6 levels observed in KS, PEL, and MCD...
  84. pmc Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalovirus latency in the lungs
    N K Grzimek
    Institute for Virology, , Mainz, Germany
    J Virol 75:2692-705. 2001
    ..Our data are consistent with a stochastic nature of enhancer action as it is proposed by the "binary" or probability model...
  85. pmc Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype
    Rafaela Holtappels
    Institute for Virology, Johannes Gutenberg University, 55101 Mainz, Germany
    J Virol 76:151-64. 2002
    ..We conclude that the low number of antigenic peptides identified so far for CMVs reflects a focused memory repertoire, and we predict that more antigenic peptides will be disclosed by analysis of the acute immune response...
  86. ncbi Seroprevalence of six different viruses among pregnant women and blood donors in rural and urban Burkina Faso: A comparative analysis
    Ellen Collenberg
    Abteilung Virologie, Universitaetsklinikum Heidelberg, Heidelberg, Germany
    J Med Virol 78:683-92. 2006
    ..3%) than in urban (36.5%) Burkina Faso...
  87. ncbi Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders
    M Q Du
    Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
    Blood 97:2130-6. 2001
    ..Activation of the IL-6 receptor signaling pathway may play a role in differentiation of KSHV-infected naive B cells into plasmablasts and development of lymphoproliferative lesions. (Blood. 2001;97:2130-2136)..
  88. pmc Cyprinid herpesvirus 3
    Benjamin Michel
    University of Liege, Liege, Belgium
    Emerg Infect Dis 16:1835-43. 2010
    ..nonreplicative). Recent advances with regard to CyHV-3 provide a role for this virus in fundamental and applied research...
  89. ncbi Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1119-26. 2008
    ..Activation of these pathways may result from altered surfactant protein processing or chronic herpesvirus infection...
  90. pmc Cloning of the koi herpesvirus genome as an infectious bacterial artificial chromosome demonstrates that disruption of the thymidine kinase locus induces partial attenuation in Cyprinus carpio koi
    B Costes
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Virol 82:4955-64. 2008
    ..The availability of the KHV BAC is an important advance that will allow the study of viral genes involved in KHV pathogenesis, as well as the production of attenuated recombinant candidate vaccines...
  91. pmc Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm
    Sergio Covarrubias
    University of California, Berkeley, 94720 3102, USA
    J Virol 83:9554-66. 2009
    ..These results have important mechanistic implications for how SOX and muSOX target nascent cellular transcripts in the nucleus. Furthermore, our findings establish MHV68 as a new, genetically tractable model to study host shutoff...
  92. ncbi Cloning, expression, purification and characterization of UL24 partial protein of duck enteritis virus
    Renyong Jia
    Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Ya an 625014, China
    Intervirology 52:326-34. 2009
    ..On the basis of subcellular location, UL24 appeared to be predominantly nuclear membrane-associated, especially at later times in infection, and provided a good tool to further study the biofunctions of UL24 protein...
  93. pmc Comparison of serologic assays and PCR for diagnosis of human herpesvirus 8 infection
    T J Spira
    Immunology Branch, Division of AIDS, STD, and TB Laboratory Research, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 38:2174-80. 2000
    ..As described above, only a titer of >/=1:40 would be considered HHV-8 positive...
  94. ncbi Water, socioeconomic factors, and human herpesvirus 8 infection in Ugandan children and their mothers
    Sam M Mbulaiteye
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
    J Acquir Immune Defic Syndr 38:474-9. 2005
    ..Human herpesvirus 8 (HHV-8) infection is common in sub-Saharan Africa, but its distribution is uneven. Transmission occurs during childhood within families by unclear routes...
  95. pmc Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2
    Xiaozhen Liang
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Virol 80:5862-74. 2006
    ..Our results suggest that gammaHV68 M2 blocks apoptosis-mediated intracellular innate immunity, which might ultimately contribute to its role in latent infection...
  96. ncbi Herpesviruses and immunity: the art of evasion
    Bryan D Griffin
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Vet Microbiol 143:89-100. 2010
    ..The subversion of the natural killer cell response by herpesvirus proteins and microRNAs is also discussed...
  97. pmc Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection
    N Saederup
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124, USA
    J Virol 75:9966-76. 2001
    ..The data further reinforce the role of MCK-2 as a proinflammatory signal that recruits leukocytes to increase the efficiency of viral dissemination in the host...
  98. ncbi Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients
    D V Ablashi
    Department of Microbiology, Georgetown University, School of Medicine, Washington, DC, USA
    J Clin Virol 16:179-91. 2000
    ..HHV-6 is a ubiquitous virus and its infection usually occurs in childhood and then becomes a latent infection. HHV-6 reactivation has been shown to play a role in the pathogenesis of AIDS and several other diseases...
  99. ncbi Specific and nonspecific NK cell activation during virus infection
    A O Dokun
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    Nat Immunol 2:951-6. 2001
    ..These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo...
  100. pmc Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda
    Lisa M Butler
    Department of Epidemiology and Biostatistics and Global Health Sciences, University of California, San Francisco, CA 94105, USA
    J Infect Dis 203:625-34. 2011
    ..We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission...
  101. pmc Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus
    O R Oakley
    Department of Clinical Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
    Clin Exp Immunol 151:155-64. 2008
    ..These data suggest that increased weight loss observed in IL-10 knock-out mice may be attributed to the uncontrolled production of proinflammatory cytokines, including IL-6...

Research Grants62

  1. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
  2. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ....
  3. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ....
  4. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..The goal of this research is to characterize the latency associated transcript gene (LAT) region and investigate the role of LAT during latency in a natural host model system. . ..
  5. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ....
  6. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..abstract_text> ..
  7. MOLECULAR GENETICS OF HSV DNA POLYMERASE GENE
    James M Hogle; Fiscal Year: 2013
    ..The research proposed should not only provide information that could aid in drug discovery and understanding how viruses become resistant to current drugs, but aims directly to discover new anti-herpesvirus drugs. ..
  8. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich-Zugich; Fiscal Year: 2012
    ....
  9. Infectious Agents and B Cell Anergy
    John C Cambier; Fiscal Year: 2013
    ..g. EBV in human and gHV68 in mouse, re-awaken anergic B cells thereby leading to autoimmunity. Results of these studies may provide new strategies for prevention, diagnosis and treatment of autoimmunity. ..
  10. Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
    Donald Coen; Fiscal Year: 2009
    ..This assay will be used to screen libraries of small molecules and natural products. "Hits" will be assayed for specificity, and for anti-HCMV activity and cytotoxicity, and then studied for their mechanisms of action. ..
  11. Renal transplant and subclinical herpesvirus infection
    Jodi Smith; Fiscal Year: 2009
    ..abstract_text> ..
  12. MOLECULAR CHARACTERIZATION OF HERPES SIMPLEX VIRUS ICP27
    Stephen A Rice; Fiscal Year: 2013
    ..It is also possible that these studies will lead to novel strategies for therapeutic modalities to prevent or treat herpesvirus infections. ..
  13. Evasion of intrinsic antiviral host cell responses by herpesviruses
    PAUL DALLING LING; Fiscal Year: 2013
    ..Our studies will yield new insights into virus-host interactions that modulate viral infections and possibly identify new viral targets for development of novel antiviral therapeutics. ..
  14. A longitudinal immunological and virological study for ME CFS biomarker discovery
    Eleanor M Riley; Fiscal Year: 2013
    ....
  15. Evasion of intrinsic antiviral host cell responses by herpesviruses
    Paul Ling; Fiscal Year: 2009
    ..Finally, targeting ORF75 for developing novel anti-gammaherpesvirus therapeutics might be a rewarding strategy, especially if it is found to possess intrinsic enzymatic functions. ..
  16. Control of Gammaherpesvirus Replication
    Samuel H Speck; Fiscal Year: 2013
    ..Understanding how virus reactivation is regulated may identify novel targets for therapeutic intervention. This grant aims to study the regulation of entry into the gamma-herpesvirus replication cycle. ..
  17. MICRORNA REGULATION OF NK CELL DEVELOPMENT AND FUNCTION
    Todd A Fehniger; Fiscal Year: 2013
    ..These studies may therefore inform future strategies to augment NK cell functionality as an immunotherapeutic strategy. ..
  18. INTERACTIONS OF PROTECTIVE IMMUNITY AND TRANSPLANTATION TOLERANCE
    Christian P Larsen; Fiscal Year: 2010
    ....
  19. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2013
    ..This technology and knowledge also will provide opportunities to develop enhanced viral tracers for understanding the organization and functional architecture of the nervous system. ..
  20. Induction of Apoptosis in T cells by Herpes Simplex Virus Type 2
    Jin Young Han; Fiscal Year: 2010
    ..This work has potential applicability in developing novel therapies to reduce public health consequences from virus reactivation in genital and neonatal infections. ..
  21. Herpes Simples Virus Capsid Assembly and DNA Packaging
    FREDERICK L HOMA; Fiscal Year: 2011
    ..These studies utilize genetic, biochemical and structural (cryoEM) approaches to understand how the protein complexes assemble and carry out the cleavage/packaging reaction. ..
  22. HERPESVIRUS GENE EXPRESSION IN TRANSFORMED CELLS
    RICHARD M LONGNECKER; Fiscal Year: 2013
    ..The results of these studies will lead to an understanding of the mechanism of herpesvirus-induced membrane fusion and to new approaches for the prevention and treatment of herpesvirus infections. ..
  23. 26th Intl Herpesvirus Workshop, Regensburg, Germany
    Jay Nelson; Fiscal Year: 2001
    ..entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy, ..
  24. 25TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay Nelson; Fiscal Year: 2000
    ....
  25. International Herpesvirus Workshop, Cairns, Australia
    Jay Nelson; Fiscal Year: 2002
    ..abstract_text> ..
  26. Role of gammaherpesvirus lytic replication-associated genes in the establishment
    Scott A Tibbetts; Fiscal Year: 2013
    ..This work has important implications for the development of drugs to prevent or treat virus-associated cancers. ..
  27. CMV ACCESSORY GENES AND RETINAL CELL INFECTION
    Lenore Pereira; Fiscal Year: 1999
    ..Findings of these studies will have far-reaching implications for understanding pathogenic mechanisms of herpesviruses and form a foundation for developing novel strategies to arrest cell-cell spread of retinal herpesvirus infections. ..
  28. 24TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Frederick Wang; Fiscal Year: 1999
    ..abstract_text> ..
  29. NEW PHENYL NUCLEOSIDES AS ANTI-HIV AGENTS
    Shashikant Phadtare; Fiscal Year: 2003
    ..abstract_text> ..
  30. STRUCTURE AND FUNCTION OF THE HSV DNA POLYMERASE
    DAVID DORSKY; Fiscal Year: 1993
    ..The in vitro translated pol and mutants will also be used as targets for affinity-labeling by photoactive nucleotide analogs and specifically designed small DNA fragments...
  31. MOLECULAR STUDIES OF HUMAN CYTOMEGALOVIRUS PROTEASE
    Liang Tong; Fiscal Year: 2003
    ....
  32. DRUGS TO PREVENT RECURRENT HERPESVIRUS INFECTIONS
    George Wright; Fiscal Year: 2001
    ..Drugs that reduce the morbidity of HSV encephalitis and neonatal herpes infections will have great benefit in these poorly managed diseases. ..
  33. TRANS-ACTIVATED EXPRESSION OF HSV IMMEDIATE EARLY GENES
    STEVEN TRIEZENBERG; Fiscal Year: 2001
    ..These experiments will bring a greater understanding not only of VP16 as a model transcriptional activator, but also of VP16 in its biological role as a key regulator of gene expression of an important human pathogen. ..
  34. Tumor-Associated Herpesviruses Conference
    Nancy Raab Traub; Fiscal Year: 2006
    ..Recognize and encourage young investigators and 3. Highlight new developments in the field and identify areas for future investigation. ..
  35. SIXTEENTH INTERNATIONAL HERPESVIRUS WORKSHOP
    Edward Mocarski; Fiscal Year: 1991
    ....
  36. TRANSCRIPTION IN HERPESVIRUS INFECTED CELLS
    John Staczek; Fiscal Year: 1990
    ..This information will be compared to data obtained in lytically infected cells in an attempt to identify alterations in virus transcription that modulate lytic infections and thus lead to oncogenic transformation/persistent infection...
  37. Mechanisms of NK Recognition of HCMV Infected Cells
    William Carr; Fiscal Year: 2005
    ..An objective of the training plan is that Dr. Carr will be competitive for a RO1 on cellular, innate immunity to be submitted by the end of the four-year award period. ..
  38. NEW CHEMICAL ENTITIES AND UNIQUE TARGETS FOR HCMV
    JOHN DRACH; Fiscal Year: 2002
    ..In these ways, we shall provide a comprehensive program for the critical initial phases of drug discovery and development of new therapies for an important AIDS-associated opportunistic infection. ..
  39. Neuroimmune Modulation of Virus Immunity In Aging
    Raymond Stowe; Fiscal Year: 2002
    ..These data will subsequently be used to support an R01 application to develop a mechanistic investigation on how neuroendocrine hormones modulate herpesvirus-specific immunity in the elderly. ..
  40. ANTIVIRAL RESISTANCE IN AIDS
    Douglas Richman; Fiscal Year: 2004
    ....
  41. RADIOIODINATED ANTIVIRALS AS DIAGNOSTIC AGENTS
    Stephen Sacks; Fiscal Year: 1990
    ..A successful outcome to these studies will directly enhance the physician's ability to diagnose serious herpesvirus infections, by increasing the rapidity of diagnosis as well as the accuracy and safety of the test...
  42. HERPES SIMPLEX VIRUS TYPE 1 GLYCOPROTEINS
    Subhendra Chattopadhyay; Fiscal Year: 1990
    ..Finally, the roles of glycoproteins in viral assembly and in induction of cell fusion will be studied through mammalian cell lines expressing cloned glycoprotein genes and by the analysis of deletion mutants in these glycoprotein genes...
  43. LIGHT- A NEW THERAPEUTIC FOR HERPESVIRUS INFECTIONS
    Theresa Banks; Fiscal Year: 2000
    ..LIGHT immunotherapy may prove beneficial for several different patient populations including transplant recipients, AIDS patients, and individuals undergoing chemotherapy/radiation. ..
  44. IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS
    BARRY ROUSE; Fiscal Year: 2005
    ..Our experiments may identify better methods of generating protective immunity against HSV. ..
  45. VIRAL KERATOCONJUNCTIVITIS AND RELATED DISORDERS
    Ernest Jawetz; Fiscal Year: 1980
    ..We hope to contribute materially in the future, as we have in the past, to improved understanding of host-parasite relationships and mechanisms of control of a number of serious external eye diseases...
  46. REGULATION OF HERPES PROTEINS IN PERSISTENT INFECTION
    Gretchen Caughman; Fiscal Year: 1993
    ..These studies will yield information not only about herpesviral gene regulation, but also about the functions of critical viral gene products in determining the outcome of herpesvirus infections. ..
  47. SALIVARY-VIRAL INTERACTIONS IN DENTAL DISEASE
    EARL BERGEY; Fiscal Year: 1992
    ....
  48. GENETICS OF RESISTANCE TO HSV-1 IN THE MOUSE
    Carlos Lopez; Fiscal Year: 1980
    ..In addition, lymphocyte-macrophage interactions leading to resistance will be investigated...
  49. Molecular dissection of specific NK cell activation
    JONATHAN HEUSEL; Fiscal Year: 2005
    ..g., in MHC class I and related loci). The results will advance our insight on the cellular and molecular bridges between innate and adaptive immunity. ..
  50. A Genetic Determinant of Resistance to HSV
    Edouard Cantin; Fiscal Year: 2006
    ..abstract_text> ..
  51. Role of EBV gene products in lung fibrogenesis
    Joseph Lasky; Fiscal Year: 2009
    ..There are currently no proven medicinal therapies for the treatment of IPF. Defining the mechanisms through which EBV gene products promote IPF will provide new options for the treatment of this fatal disease. ..
  52. DEFECTIVE CD8 T CELL-MEDIATED CONTROL IN AIDS
    Susan Plaeger; Fiscal Year: 1992
    ....
  53. ROLE OF HERPESVIRUS COMPLEMENT BINDING GYCOPROTEIN
    Betsy Herold; Fiscal Year: 1993
    ..The knowledge gained from these studies will help further formulate theories on viral infectivity and may lead to promising new treatment modalities in the management of herpesvirus infections...
  54. Novel inhibitors of the replication of poxviruses
    Johan Neyts; Fiscal Year: 2004
    ..The final goal of this application is to advance a compound for the treatment of (systemic or cutaneous) poxvirus infections to the initial stages of development, i.e., selecting an IND candidate. ..
  55. Survival Signals in AIDS Lymphomas
    Ethel Cesarman; Fiscal Year: 2010
    ..Our data will help elucidate how best to inhibit EBV to improve the treatment of AIDS patients with lymphoma. ..
  56. Identifying small molecule inhibitors of KSHV vFLIP-TRAF2 interactions.
    Ethel Cesarman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Does the HSV-1 latency associated transcript (LAT) encode a protein?
    Clinton Jones; Fiscal Year: 2008
    ..Studies will also determine whether LAT encoded proteins inhibit apoptosis, and whether these proteins are necessary for the latency reactivation cycle. [unreadable] [unreadable] [unreadable]..