poliomyelitis

Summary

Summary: An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)

Top Publications

  1. ncbi Vaccine-derived polioviruses and the endgame strategy for global polio eradication
    Olen M Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Microbiol 59:587-635. 2005
  2. pmc What led to the Nigerian boycott of the polio vaccination campaign?
    Ayodele Samuel Jegede
    University of Toronto Joint Centre for Bioethics, Toronto, ON, Canada
    PLoS Med 4:e73. 2007
  3. ncbi Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus
    Olen Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Atlanta, GA 30333, USA
    Science 296:356-9. 2002
  4. pmc The final stages of the global eradication of poliomyelitis
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120140. 2013
  5. pmc Circulation of endemic type 2 vaccine-derived poliovirus in Egypt from 1983 to 1993
    Chen Fu Yang
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 77:8366-77. 2003
  6. ncbi Identification and control of a poliomyelitis outbreak in Xinjiang, China
    Hui Ming Luo
    From the Chinese Center for Disease Control and Prevention, National Immunization Program H M L, W Z Y, N W, H Q W, H B W, J S Z, F Q C, L X H, C X F, G J N, D W L, G M Z, Y S C, Y M L, D P Y, K L L, Y W, W Z Y, the Ministry of Health Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention Y Z, D M Y, D X L, S L Z, S W W, D Y W, G H H, H Z, Y X J, W B X, the Health Emergency Control Center Z J F, Turkey
    N Engl J Med 369:1981-90. 2013
  7. ncbi Implications of a circulating vaccine-derived poliovirus in Nigeria
    Helen E Jenkins
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    N Engl J Med 362:2360-9. 2010
  8. pmc Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication
    Ping Jiang
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Proc Natl Acad Sci U S A 104:9457-62. 2007
  9. ncbi Reaching the last one per cent: progress and challenges in global polio eradication
    Olen Kew
    Division of Viral Diseases, G 10, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Curr Opin Virol 2:188-98. 2012
  10. pmc From emergence to eradication: the epidemiology of poliomyelitis deconstructed
    Neal Nathanson
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Am J Epidemiol 172:1213-29. 2010

Research Grants

Detail Information

Publications358 found, 100 shown here

  1. ncbi Vaccine-derived polioviruses and the endgame strategy for global polio eradication
    Olen M Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Microbiol 59:587-635. 2005
    ..during OPV replication in humans and is the underlying cause of the rare cases of vaccine-associated paralytic poliomyelitis (VAPP) in OPV recipients and their close contacts...
  2. pmc What led to the Nigerian boycott of the polio vaccination campaign?
    Ayodele Samuel Jegede
    University of Toronto Joint Centre for Bioethics, Toronto, ON, Canada
    PLoS Med 4:e73. 2007
  3. ncbi Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus
    Olen Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Atlanta, GA 30333, USA
    Science 296:356-9. 2002
    An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001...
  4. pmc The final stages of the global eradication of poliomyelitis
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120140. 2013
    The global incidence of poliomyelitis has dropped by more than 99 per cent since the governments of the world committed to eradication in 1988...
  5. pmc Circulation of endemic type 2 vaccine-derived poliovirus in Egypt from 1983 to 1993
    Chen Fu Yang
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 77:8366-77. 2003
    From 1988 to 1993, 30 cases of poliomyelitis associated with poliovirus type 2 were found in seven governorates of Egypt...
  6. ncbi Identification and control of a poliomyelitis outbreak in Xinjiang, China
    Hui Ming Luo
    From the Chinese Center for Disease Control and Prevention, National Immunization Program H M L, W Z Y, N W, H Q W, H B W, J S Z, F Q C, L X H, C X F, G J N, D W L, G M Z, Y S C, Y M L, D P Y, K L L, Y W, W Z Y, the Ministry of Health Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention Y Z, D M Y, D X L, S L Z, S W W, D Y W, G H H, H Z, Y X J, W B X, the Health Emergency Control Center Z J F, Turkey
    N Engl J Med 369:1981-90. 2013
    ..of infection with wild-type poliovirus indigenous to China was reported in 1994, and China was certified as a poliomyelitis-free region in 2000...
  7. ncbi Implications of a circulating vaccine-derived poliovirus in Nigeria
    Helen E Jenkins
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    N Engl J Med 362:2360-9. 2010
    ....
  8. pmc Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication
    Ping Jiang
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Proc Natl Acad Sci U S A 104:9457-62. 2007
    ..in CD155 transgenic mice, the large majority of circulating vaccine-derived PVs that have caused poliomyelitis outbreaks in different parts of the world...
  9. ncbi Reaching the last one per cent: progress and challenges in global polio eradication
    Olen Kew
    Division of Viral Diseases, G 10, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Curr Opin Virol 2:188-98. 2012
    ....
  10. pmc From emergence to eradication: the epidemiology of poliomyelitis deconstructed
    Neal Nathanson
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Am J Epidemiol 172:1213-29. 2010
    b>Poliomyelitis has appeared in epidemic form, become endemic on a global scale, and been reduced to near-elimination, all within the span of documented medical history...
  11. pmc Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease
    Nogi Park
    Department of Basic Medical Sciences, University of Arizona College of Medicine Phoenix, Phoenix, Arizona 85004, USA
    J Biol Chem 285:28796-805. 2010
    ..These results are consistent with a model whereby PV and HRV disrupt nucleo-cytoplasmic trafficking by selectively removing FG repeat domains from a subset of nuclear pore complex proteins...
  12. pmc The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus
    Miki Ida-Hosonuma
    Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Tokyo 183 8526, Japan
    J Virol 79:4460-9. 2005
    ..We consider that poliovirus replication was observed in the nontarget tissues of PVR-transgenic/Ifnar knockout mice because the IFN response was null in all tissues...
  13. pmc Complex dynamic development of poliovirus membranous replication complexes
    George A Belov
    Virginia Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 86:302-12. 2012
    ..Thus, it is likely that there is a fundamental divergence in the requirements for the supporting cellular membrane-shaping machinery among different groups of positive-strand RNA viruses...
  14. ncbi New strategies for the elimination of polio from India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, UK
    Science 314:1150-3. 2006
    ..We analyze strategies to counteract this and show that switching to monovalent vaccine may finally interrupt virus transmission...
  15. ncbi Investigation of elevated case-fatality rate in poliomyelitis outbreak in Pointe Noire, Republic of Congo, 2010
    Christopher J Gregory
    Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    Clin Infect Dis 55:1299-306. 2012
    ..We conducted an investigation to identify factors associated with fatal outcomes among persons with poliomyelitis in Pointe Noire.
  16. ncbi Immunogenicity of supplemental doses of poliovirus vaccine for children aged 6-9 months in Moradabad, India: a community-based, randomised controlled trial
    Concepcion F Estivariz
    Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet Infect Dis 12:128-35. 2012
    ....
  17. pmc Poliomyelitis outbreak, Pointe-Noire, Republic of the Congo, September 2010-February 2011
    Arnaud Le Menach
    Health Protection Agency, London, UK
    Emerg Infect Dis 17:1506-9. 2011
    On November 4, 2010, the Republic of the Congo declared a poliomyelitis outbreak. A cross-sectional survey in Pointe-Noire showed poor sanitary conditions and low vaccination coverage (55.5%), particularly among young adults...
  18. ncbi Randomized controlled clinical trial of fractional doses of inactivated poliovirus vaccine administered intradermally by needle-free device in Cuba
    Sonia Resik
    Pedro Kouri Institute, Havana, Cuba
    J Infect Dis 201:1344-52. 2010
    ..As part of an evaluation of strategies to make inactivated poliovirus vaccine (IPV) affordable for developing countries, we conducted a clinical trial of fractional doses of IPV in Cuba...
  19. pmc Recombination between polioviruses and co-circulating Coxsackie A viruses: role in the emergence of pathogenic vaccine-derived polioviruses
    Sophie Jegouic
    Institut Pasteur, Unité de Biologie des virus entériques, Paris, France
    PLoS Pathog 5:e1000412. 2009
    Ten outbreaks of poliomyelitis caused by pathogenic circulating vaccine-derived polioviruses (cVDPVs) have recently been reported in different regions of the world. Two of these outbreaks occurred in Madagascar...
  20. ncbi The dependence of viral RNA replication on co-opted host factors
    Peter D Nagy
    Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, Kentucky 40546, USA
    Nat Rev Microbiol 10:137-49. 2012
    ..This Review presents the recent progress that has been made in understanding the role of co-opted host proteins and membranes during (+)RNA virus replication, and discusses common themes employed by different viruses...
  21. ncbi An outbreak of poliomyelitis caused by type 1 vaccine-derived poliovirus in China
    Xiaofeng Liang
    National Immunization Programme, China Center for Disease Control and Prevention, Beijing, People s Republic of China, 100044
    J Infect Dis 194:545-51. 2006
    ..In May-July 2004, type 1 vaccine-derived poliovirus (VDPV) was isolated from 2 case patients with polio and a contact of a third case patient in Guizhou Province...
  22. pmc Virus attenuation by genome-scale changes in codon pair bias
    J Robert Coleman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Science 320:1784-7. 2008
    ..Polioviruses thus customized were used to immunize mice and provided protective immunity after challenge. This "death by a thousand cuts" strategy could be generally applicable to attenuating many kinds of viruses...
  23. ncbi Characterization of a recombinant type 3/type 2 poliovirus isolated from a healthy vaccinee and containing a chimeric capsid protein VP1
    Soile Blomqvist
    Department of Microbiology, Enterovirus Laboratory, National Public Health Institute KTL, Mannerheimintie 166, 00300 Helsinki, Finland
    J Gen Virol 84:573-80. 2003
    ..Our results suggest that the chimeric virus was most likely generated by recombination events in the vaccinee, rather than representing progeny of circulating vaccine-derived virus...
  24. ncbi Seroprevalence of vaccine preventable and blood transmissible viral infections (measles, mumps, rubella, polio, HBV, HCV and HIV) in medical students
    Sabine Wicker
    Occupational Health Service, University Hospital of Frankfurt, 60590 Frankfurt Main, Germany
    Med Microbiol Immunol 196:145-50. 2007
    ..1% (type 1), 96.9% (type 2) and 70% (type 3). 68.2% had antibodies (titer 1:> or =10) against all three virus types. The partly significant gaps of immunity in the students need to be closed prior to the first contact with patients...
  25. pmc Neurovirulent vaccine-derived polioviruses in sewage from highly immune populations
    Lester M Shulman
    Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel
    PLoS ONE 1:e69. 2006
    Vaccine-derived polioviruses (VDPVs) have caused poliomyelitis outbreaks in communities with sub-optimal vaccination...
  26. ncbi Prolonged detection of indigenous wild polioviruses in sewage from communities in Egypt
    Laila El Bassioni
    Egyptian Organization for Biological Products and Vaccine Production, Cairo, Egypt
    Am J Epidemiol 158:807-15. 2003
    ..were detected in 57% of the sewage samples and 91% of the study sites, only two of which reported paralytic poliomyelitis cases in 2001...
  27. pmc Immunity status of adults and children against poliomyelitis virus type 1 strains CHAT and Sabin (LSc-2ab) in Germany
    Maren Eggers
    Labor Prof, G, Enders and Partner and Institute of Virology, Infectious Diseases and Epidemiology eV, Stuttgart, Germany
    BMC Infect Dis 10:347. 2010
    ..In Germany, vaccination against poliomyelitis was introduced in 1962 using the oral polio vaccine (OPV) containing Sabin strain LSc-2ab...
  28. ncbi CpG oligodeoxynucleotides are a potent adjuvant for an inactivated polio vaccine produced from Sabin strains of poliovirus
    Chunting Yang
    Department of Virology, National Vaccine and Serum Institute, No 4 San Jian Fang Nan Li, Chao Yang District, Beijing 100024, China
    Vaccine 27:6558-63. 2009
    ..Therefore, our study suggests that the global use of IPV could be facilitated by using CpG-ODN or other feasible adjuvants...
  29. pmc Circulating vaccine-derived polioviruses: current state of knowledge
    Olen M Kew
    WHO Global Specialized Reference Laboratory, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Bull World Health Organ 82:16-23. 2004
    Within the past 4 years, poliomyelitis outbreaks associated with circulating vaccine-derived polioviruses (cVDPVs) have occurred in Hispaniola (2000-01), the Philippines (2001), and Madagascar (2001-02)...
  30. ncbi Fractional doses of inactivated poliovirus vaccine in Oman
    Ali Jafer Mohammed
    Ministry of Health, Oman
    N Engl J Med 362:2351-9. 2010
    ..We conducted a clinical trial of fractional doses of inactivated poliovirus vaccine administered to infants in Oman, in order to evaluate strategies for making the vaccine affordable for use in developing countries...
  31. ncbi Waning intestinal immunity after vaccination with oral poliovirus vaccines in India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Infect Dis 205:1554-61. 2012
    ..Mucosal immunity is thought to wane over time but the rate of loss of protection has not been examined...
  32. ncbi Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children
    Marie Line Joffret
    Departement de Virologie, Institut Pasteur, Unité de Biologie des virus entériques, France
    J Infect Dis 205:1363-73. 2012
    Five cases of poliomyelitis due to type 2 or 3 recombinant vaccine-derived polioviruses (VDPVs) were reported in the Toliara province of Madagascar in 2005.
  33. pmc The effect of mass immunisation campaigns and new oral poliovirus vaccines on the incidence of poliomyelitis in Pakistan and Afghanistan, 2001-11: a retrospective analysis
    Kathleen M O'Reilly
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK
    Lancet 380:491-8. 2012
    ..The increasing incidence of poliomyelitis in these countries during 2010-11 led the Executive Board of WHO in January, 2012, to declare polio ..
  34. ncbi Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis
    Vaia Pliaka
    University of Thessaly, School of Health Sciences, Department of Biochemistry and Biotechnology, Microbiology Virology Laboratory, Larissa, Greece
    Expert Rev Vaccines 11:609-28. 2012
    The Global Polio Eradication Initiative was launched in 1988 with the aim to eliminate paralytic poliomyelitis. Two effective vaccines are available: inactivated polio vaccine (IPV) and oral polio vaccine (OPV)...
  35. ncbi Sabin and wild polioviruses from apparently healthy primary school children in northeastern Nigeria
    M M Baba
    World Health Organization National ITD Polio Laboratory, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
    J Med Virol 84:358-64. 2012
    ....
  36. ncbi Molecular evolution of oral poliovirus vaccine strains during multiplication in humans and possible implications for global eradication of poliovirus
    F Friedrich
    Departamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    Acta Virol 44:109-17. 2000
    The oral poliovirus vaccine (OPV) has been effectively used in the control of poliomyelitis and in the eradication of wild polioviruses...
  37. pmc Determinants of performance of supplemental immunization activities for polio eradication in Uttar Pradesh, India: social mobilization activities of the Social mobilization Network (SM Net) and Core Group Polio Project (CGPP)
    William M Weiss
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Suite E8132, Baltimore, MD 21205, USA
    BMC Infect Dis 13:17. 2013
    ..In this paper, we examine the reasons the CORE Group had been successful through exploration of which social mobilization activities of the CORE Group predicted better performance of SIAs...
  38. ncbi Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial
    Guoyang Liao
    Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, China
    J Infect Dis 205:237-43. 2012
    ..We conducted a phase II, randomized, positive-controlled trial to assess the safety and immunogenicity of Sabin IPV...
  39. pmc Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors
    L Fiette
    Unite des Virus Lents, UA 1157 Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
    J Exp Med 181:2069-76. 1995
    ..They also lend support to the notion that the Ifg gene is involved in the resistance/susceptibility of inbred strains of mice to persistent infection by this picornavirus...
  40. ncbi Priming after a fractional dose of inactivated poliovirus vaccine
    Sonia Resik
    Pedro Kouri Institute, Havana, Cuba
    N Engl J Med 368:416-24. 2013
    ..To reduce the costs of maintaining a poliovirus immunization base in low-income areas, we assessed the extent of priming immune responses after the administration of inactivated poliovirus vaccine (IPV)...
  41. pmc A statistical model of the international spread of wild poliovirus in Africa used to predict and prevent outbreaks
    Kathleen M O'Reilly
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom
    PLoS Med 8:e1001109. 2011
    Outbreaks of poliomyelitis in African countries that were previously free of wild-type poliovirus cost the Global Polio Eradication Initiative US$850 million during 2003-2009, and have limited the ability of the program to focus on ..
  42. ncbi Qualitative study of wild polio cases in high risk districts of Uttar Pradesh, India
    Jugal Kishore
    Department of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India
    Natl Med J India 16:131-4. 2003
    ..We did a qualitative survey in certain districts of western Uttar Pradesh to determine the reasons for continued occurrence of wild polio cases...
  43. ncbi Fcgamma receptor IIIA polymorphism as a risk factor for acute poliomyelitis
    Tiina Rekand
    Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    J Infect Dis 186:1840-3. 2002
    b>Poliomyelitis is a viral infection that causes flaccid paralysis in approximately 1% of cases. The Fc receptors for immunoglobulin G (FcgammaR) are associated with modifying effects of several infectious and autoimmune diseases...
  44. ncbi Polio eradication initiative in India: deconstructing the GPEI
    C Sathyamala
    Centre of Social Medicine and Community Health, Jawaharlal Nehru University, New Delhi, India
    Int J Health Serv 35:361-83. 2005
    ..They conclude that the GPEI is yet another exercise in mismanaging the health priorities and programs in developing countries in the era of globalization...
  45. ncbi Polio eradication in India: the way forward
    S K Mittal
    Department of Pediatrics, Max Hospital, Pitampura, India
    Indian J Pediatr 74:153-60. 2007
    Despite remarkable decline in the number of poliomyelitis cases, the dream of polio eradication in India remains elusive. This is despite considerable effort and expenditure for well over a decade...
  46. pmc Vaccine-associated paralytic polio in India
    T Jacob John
    Bull World Health Organ 80:917. 2002
  47. ncbi Asymptomatic wild-type poliovirus infection in India among children with previous oral poliovirus vaccination
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    J Infect Dis 201:1535-43. 2010
    ....
  48. pmc Outcomes of polio eradication activities in Uttar Pradesh, India: the Social Mobilization Network (SM Net) and Core Group Polio Project (CGPP)
    William M Weiss
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Suite E8132, Baltimore, MD 21205, USA
    BMC Infect Dis 11:117. 2011
    ..In this paper, we examine the vaccination outcomes in districts of SM Net where the CORE Group works...
  49. ncbi The complexity of social mobilization in health communication: top-down and bottom-up experiences in polio eradication
    Rafael Obregón
    School of Media Arts and Studies, Ohio University, Athens, Ohio 45701, USA
    J Health Commun 15:25-47. 2010
    ..Further studies using these perspectives should be a priority for global health programs, including studies of the trust level, or lack thereof, among social actors...
  50. ncbi Poliomyelitis outbreaks in Angola genetically linked to India: risk factors and implications for prevention of outbreaks due to wild poliovirus importations
    Sarah Kidd
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA United States
    Vaccine 29:3760-6. 2011
    We conducted an investigation of two outbreaks of poliomyelitis in Angola during 2007-2008 due to wild poliovirus (WPV) genetically linked to India...
  51. ncbi Immunogenicity of bivalent types 1 and 3 oral poliovirus vaccine: a randomised, double-blind, controlled trial
    Roland W Sutter
    World Health Organization, Geneva, Switzerland
    Lancet 376:1682-8. 2010
    Poliovirus types 1 and 3 co-circulate in poliomyelitis-endemic countries. We aimed to assess the immunogenicity of a novel bivalent types 1 and 3 oral poliovirus vaccine (bOPV).
  52. ncbi Trial of a supplemental dose of four poliovirus vaccines
    R W Sutter
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 343:767-73. 2000
    ..We conducted a multicenter trial in Oman to evaluate the response to a supplemental dose of four poliovirus vaccine formulations...
  53. pmc Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995-2008
    Shohreh Shahmahmoodi
    Tehran University of Medical Sciences, 14194 Tehran, Iran
    Emerg Infect Dis 16:1133-6. 2010
    To determine the prevalence of vaccine-associated paralytic poliomyelitis (VAPP) in immunodeficient infants, we reviewed all documented cases caused by immunodeficiency-associated vaccine-derived polioviruses in Iran from 1995 through ..
  54. ncbi Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus
    T M Herremans
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    J Immunol 162:5011-8. 1999
    The inactivated poliovirus vaccine (IPV) is used for protection against poliomyelitis in The Netherlands. It is not clear, however, whether IPV vaccination can lead to priming of the mucosal immune system and the induction of IgA...
  55. ncbi Communication for polio eradication: improving the quality of communication programming through real-time monitoring and evaluation
    Silvio Waisbord
    School of Media and Public Affairs, George Washington University, Washington, DC, USA
    J Health Commun 15:9-24. 2010
    ....
  56. ncbi Vaccine-derived poliovirus (VDPV): Impact on poliomyelitis eradication
    Philip Minor
    Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshirre EN6 3QG, UK
    Vaccine 27:2649-52. 2009
    ..This may, in rare cases, cause vaccine-associated paralytic poliomyelitis (VAPP) in vaccinees or result in transmissible and neurovirulent circulating vaccine-derived poliovirus (cVDPV)..
  57. ncbi Isolation of vaccine-derived polioviruses in the Slovak Republic
    B Cernáková
    National Reference Centres, Public Health Office of the Slovak Republic, Trnavska 52, 82645 Bratislava, Slovak Republic
    Eur J Clin Microbiol Infect Dis 24:438-9. 2005
  58. pmc Impact of targeted programs on health systems: a case study of the polio eradication initiative
    Benjamin Loevinsohn
    Department of Vaccines and Biologicals, World Health Organization, 20 Ave Appia, 1211 Geneva 27, Switzerland
    Am J Public Health 92:19-23. 2002
    ..Improved planning in disease eradication initiatives can minimize disruptions in the delivery of other services. Future initiatives should include indicators and baseline data for monitoring effects on health systems development...
  59. pmc Intratypic recombination among lineages of type 1 vaccine-derived poliovirus emerging during chronic infection of an immunodeficient patient
    Chen Fu Yang
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:12623-34. 2005
    ..nine type 1 immunodeficient vaccine-derived poliovirus (iVDPV) isolates obtained over a 337-day period from a poliomyelitis patient from Taiwan with common variable immunodeficiency...
  60. pmc Outbreak of type 2 vaccine-derived poliovirus in Nigeria: emergence and widespread circulation in an underimmunized population
    Steven Wassilak
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 203:898-909. 2011
    ..Strengthened routine immunization programs in countries with suboptimal coverage and balanced use of OPV formulations in SIAs are necessary to minimize risks of VDPV emergence and circulation...
  61. ncbi Poliovirus-specific memory immunity in seronegative elderly people does not protect against virus excretion
    Frithjofna Abbink
    Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 191:990-9. 2005
    ..We examined whether people with low or undetectable antibody levels are susceptible to infection and whether memory immunity provides protection against virus excretion...
  62. pmc Surveillance of acute flaccid paralysis in the Marches region (Italy): 1997-2007
    Marcello M D'Errico
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Italy
    BMC Infect Dis 8:135. 2008
    The last case of poliomyelitis due to transmission of indigenous wild poliovirus occurred in Italy in 1982, however, it is important to guarantee a high quality surveillance as there is a risk of importation of cases from areas where ..
  63. pmc Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis
    Javier Martin
    Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom
    J Virol 76:10921-8. 2002
    The isolation of a capsid intertypic poliovirus recombinant from a child with vaccine-associated paralytic poliomyelitis is described...
  64. pmc Prolonged replication of a type 1 vaccine-derived poliovirus in an immunodeficient patient
    O M Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 36:2893-9. 1998
    VP1 sequences were determined for poliovirus type 1 isolates obtained over a 189-day period from a poliomyelitis patient with common variable immunodeficiency syndrome (a defect in antibody formation)...
  65. ncbi Protective efficacy of a monovalent oral type 1 poliovirus vaccine: a case-control study
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet 369:1356-62. 2007
    ..A high-potency monovalent oral type 1 poliovirus vaccine (mOPV1) was developed in 2005 to tackle persistent poliovirus transmission in the last remaining infected countries. Our aim was to assess the efficacy of this vaccine in India...
  66. ncbi Transmission of imported vaccine-derived poliovirus in an undervaccinated community in Minnesota
    James P Alexander
    National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 199:391-7. 2009
    ..An investigation was conducted to determine the source of the virus and its means of transmission...
  67. pmc Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 78:13512-21. 2004
    ..Type 1 cVDPV was last detected in the Philippines in September 2001, and population immunity to polio was raised by extensive OPV campaigns in late 2001 and early 2002...
  68. ncbi Deconstructing social resistance to pulse polio campaign in two North Indian districts
    Sanjay Chaturvedi
    INCLEN Trust International, INCLEN Executive Office, New Delhi
    Indian Pediatr 46:963-74. 2009
    ..To gain an insight into the phenomenon of social resistance and rumors against pulse polio campaign...
  69. pmc Virus-specific CD4+ and CD8+ cytotoxic T-cell responses and long-term T-cell memory in individuals vaccinated against polio
    Rahnuma Wahid
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 511, Little Rock, AR 72205, USA
    J Virol 79:5988-95. 2005
    ..Thus, immunity to PV vaccination involves not only an effective neutralizing antibody titer but also long-term CD4(+) and CD8(+) cytotoxic T-cell responses...
  70. ncbi Monovalent type 1 oral poliovirus vaccine in newborns
    Nasr El-Sayed
    Ministry of Health and Population, Cairo, Egypt
    N Engl J Med 359:1655-65. 2008
    In 1988, the World Health Assembly resolved to eradicate poliomyelitis. Although substantial progress toward this goal has been made, eradication remains elusive...
  71. ncbi Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy
    Matteo Zignol
    Department of Pediatrics, Faculty of Medicine and Surgery, University of Padua, Padua, Italy
    Cancer 101:635-41. 2004
    ....
  72. ncbi Histopathologically proven poliomyelitis with quadriplegia and loss of brainstem function due to West Nile virus infection
    Shira I Doron
    Department of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA, USA
    Clin Infect Dis 37:e74-7. 2003
    ..We report histopathological confirmation of this poliomyelitis-like syndrome in a patient with WNV infection in Massachusetts.
  73. pmc Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome
    Seii Ohka
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Virol 78:7186-98. 2004
    ..These results suggest that direct efficient interaction between the cytoplasmic domain and Tctex-1 is essential for the efficient retrograde transport of PV-containing vesicles along microtubules in vivo...
  74. pmc Eradication of poliomyelitis in countries affected by conflict
    R H Tangermann
    World Health Organization, Geneva, Switzerland
    Bull World Health Organ 78:330-8. 2000
    The global initiative to eradicate poliomyelitis is focusing on a small number of countries in Africa (Angola, Democratic Republic of the Congo, Liberia, Sierra Leone, Somalia, Sudan) and Asia (Afghanistan, Tajikistan), where progress ..
  75. ncbi Sabin monovalent oral polio vaccines: review of past experiences and their potential use after polio eradication
    V M Caceres
    National Immunization Program, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Clin Infect Dis 33:531-41. 2001
    ..of polio is achieved, there will be a need for stockpiles of vaccine to combat potential outbreaks of poliomyelitis caused by (1) unforeseen release of polioviruses, (2) continued circulation of vaccine-derived strains, or (3) ..
  76. ncbi Recommendations of 2nd National Consultative Meeting of Indian Academy of Pediatrics (IAP) on polio eradication and improvement of routine immunization
    Vipin M Vashishtha
    Indian Pediatr 45:367-78. 2008
    ....
  77. doi Immunisation against poliomyelitis: moving forward
    Ellie Ehrenfeld
    National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2220, USA
    Lancet 371:1385-7. 2008
  78. pmc Future of polio vaccines
    Ellie Ehrenfeld
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Expert Rev Vaccines 8:899-905. 2009
    Over the past half-century, global use of highly effective vaccines against poliomyelitis brought this disease to the brink of elimination...
  79. pmc Achieving polio eradication: a review of health communication evidence and lessons learned in India and Pakistan
    Rafael Obregón
    School of Media Arts and Studies, Ohio University, Athens, OH, United States of America
    Bull World Health Organ 87:624-30. 2009
    ..The review concludes with observations about the added value of communication strategies in polio eradication efforts and implications for global and local public health communication interventions...
  80. ncbi Effectiveness of immunization against paralytic poliomyelitis in Nigeria
    Helen E Jenkins
    Medical Research Council Centre for Outbreak Analysis and Modeling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    N Engl J Med 359:1666-74. 2008
    The number of cases of paralytic poliomyelitis has declined in Nigeria since the introduction of newly licensed monovalent oral poliovirus vaccines and new techniques of vaccine delivery...
  81. pmc Immunity status against poliomyelitis in Germany: determination of cut-off values in International Units
    Sabine Diedrich
    Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    BMC Infect Dis 2:2. 2002
    ..Standard methodology for determination of polio antibodies is a feature aimed at obtaining consistent results. An International Standard Serum for polio antibodies exists, but no protective level in International Units is defined...
  82. ncbi Will India need inactivated poliovirus vaccine (IPV) to complete polio eradication?
    T Jacob John
    Indian J Med Res 122:365-7. 2005
  83. ncbi Vaccine-associated paralytic poliomyelitis and other diseases with acute flaccid paralysis syndrome in Belarus
    E O Samoilovich
    Research Institute for Epidemiology and Microbiology, Ministry of Health, Minsk, Republic of Belarus
    Cent Eur J Public Health 11:213-8. 2003
    ..According to the final classification, 11 AFP cases were classified as vaccine-associated paralytic poliomyelitis (VAPP)...
  84. ncbi IAP recommendations on Polio Eradication and Improvement of Routine Immunization
    Roland W Sutter
    Indian Pediatr 45:353-5. 2008
  85. ncbi Respiratory function during wakefulness and sleep among survivors of respiratory and non-respiratory poliomyelitis
    T E Dolmage
    Dept of Medicine, University of Toronto, West Park Hospital, Canada
    Eur Respir J 5:864-70. 1992
    ..There were no differences among groups for diffusion, flow rates and chemoreflexes. All other polio survivors showed essentially normal respiratory function.(ABSTRACT TRUNCATED AT 250 WORDS)..
  86. pmc Risk of vaccine-associated paralytic poliomyelitis in Latin America, 1989-91
    J K Andrus
    Expanded Programme on Immunization, WHO Regional Office for South East Asia, New Delhi, India
    Bull World Health Organ 73:33-40. 1995
    A major factor influencing the success of poliomyelitis eradication in the Americas was the reliance on mass immunization campaigns with oral poliovirus vaccine (OPV)...
  87. ncbi Intradermal fractional booster dose of inactivated poliomyelitis vaccine with a jet injector in healthy adults
    Darius Soonawala
    Leiden University Medical Center LUMC, Department of Infectious Diseases, Leiden, The Netherlands
    Vaccine 31:3688-94. 2013
    For global eradication of poliomyelitis, inactivated poliovirus vaccine (IPV) needs to become available in all countries...
  88. ncbi Two good reasons to drop type 2 virus from oral polio vaccine
    T Jacob John
    Lancet 364:1666. 2004
  89. ncbi Infectious disease. Polio experts strive to understand a puzzling outbreak
    Leslie Roberts
    Science 312:1581. 2006
  90. ncbi Polio eradication in India: what is the future?
    T Jacob John
    IAP Polio Eradication Committee, 439, Civil Supplies Godown Lane, Kamalakshipuram, Vellore, Tamil Nadu 632 002, India
    Indian Pediatr 40:455-62. 2003
  91. ncbi Seroprevalence of antibodies to poliovirus in individuals living in Portugal, 2002
    M Pires de Miranda
    Unidade de Vírus Respiratórios e Enterovirus, Instituto Nacional de Saude, Unit of Respiratory and Enteroviruses, National Health Institute, INS, Lisbon, Portugal
    Euro Surveill 12:E7-8. 2007
    The last case of poliomyelitis in Portugal caused by indigenous wild poliovirus occurred in 1986 and the country was declared polio-free in 2002. High levels of immunity must be maintained to prevent the importation of wild poliovirus...
  92. ncbi [Spinal anesthesia in a patient with hemiparesis after poliomyelitis]
    Tomoaki Higashizawa
    Department of Anesthesia, Sakai Hospital in Institute of Basic Clinical Medicine, Kinki University, Sakai 590 0132
    Masui 52:1335-7. 2003
    ..man who underwent transurethral resection of the prostate (TUR-P), had carried over the palsy after poliomyelitis inflicted at one year of age...
  93. ncbi Paralytic poliomyelitis in a rural area of north India
    M Varghese
    St Stephen s Hospital, Tis Hazari, New Delhi, India
    Natl Med J India 10:8-10. 1997
    BACKGROUND: Paralysis due to poliomyelitis is common in rural areas...
  94. ncbi Reducing resistance against polio drops
    M Athar Ansari
    Department of Community Medicine, J N Medical College, A M U, Aligarh 202002, India
    J R Soc Promot Health 127:276-9. 2007
    ..The present study was carried out to impart correct health education regarding polio eradication programme and to assess the impact of social mobilization of a Muslim community carried out by medical interns...
  95. ncbi Electrodiagnostic features of acute paralytic poliomyelitis associated with West Nile virus infection
    Amer Al-Shekhlee
    Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106 5040, USA
    Muscle Nerve 29:376-80. 2004
    ..Guillain-Barré syndrome (GBS) has also been described, but acute paralytic poliomyelitis has only recently been recognized...
  96. ncbi The golden jubilee of vaccination against poliomyelitis
    T Jacob John
    Indian J Med Res 119:1-17. 2004
    ..Had we strictly followed the principles of science and health economics, perhaps we could have achieved success earlier and cheaper, with the absence of vaccine-induced polio as the bonus...
  97. ncbi Immunity to poliomyelitis in The Netherlands
    M A Conyn-van Spaendonck
    Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Am J Epidemiol 153:207-14. 2001
    Despite a vaccination coverage rate of 97%, several poliomyelitis outbreaks occurred in the Netherlands during the last three decades, all among sociogeographically clustered, unvaccinated persons...
  98. ncbi Vaccine-derived poliovirus from long term excretors and the end game of polio eradication
    Javier Martin
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Biologicals 34:117-22. 2006
    ..The relevance of these cases in the context of the global polio eradication initiative and the design of vaccination strategies for the last stages of eradication and the post-eradication era are discussed...
  99. ncbi Outbreak of poliomyelitis in Finland in 1984-85 - Re-analysis of viral sequences using the current standard approach
    Marja Leena Simonen
    Gastrointestinal Infections Unit, Department of Infectious Disease Surveillance and Control, Division of Health Protection, National Institute for Health and Welfare THL, P O Box 30, FI 00271 Helsinki, Finland
    Virus Res 147:91-7. 2010
    In 1984, a wild type 3 poliovirus (PV3/FIN84) spread all over Finland causing nine cases of paralytic poliomyelitis and one case of aseptic meningitis. The outbreak was ended in 1985 with an intensive vaccination campaign...
  100. ncbi An open-label, randomized, multicenter study of the safety, tolerability, and immunogenicity of quadrivalent human papillomavirus (types 6/11/16/18) vaccine given concomitantly with diphtheria, tetanus, pertussis, and poliomyelitis vaccine in healthy adol
    Timo Vesikari
    Vaccine Research Centre, University of Tampere Medical School, Tampere, Finland
    Pediatr Infect Dis J 29:314-8. 2010
    ..In this study, we evaluated the immunogenicity and safety of GARDASIL administered concomitantly with REPEVAX (diphtheria, tetanus, acellular pertussis, and poliomyelitis vaccine).
  101. ncbi [The German Health Interview and Examination Survey for Children and Adolescents (KiGGS): state of immunity against poliomyelitis in German children]
    S Diedrich
    Robert Koch Institut, Berlin, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:771-4. 2007
    One of the goals of the WHO is the worldwide eradication of poliomyelitis in the coming years. Europe was declared poliofree in 2002, but increasing migration may lead to a come-back of circulating polioviruses...

Research Grants62

  1. RISK FACTORS FOR YOUNG ADULT HODGKIN'S DISEASE IN TWINS
    Wendy Cozen; Fiscal Year: 2004
    ..pattern (highest risk in young white adults of high social class), are reminiscent of the risk pattern for poliomyelitis. The etiologic mechanism may involve relative social isolation and protection from exposure to common ..
  2. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013
    ..human enteroviruses cause a diverse spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of neonates...
  3. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..Live vaccinia virus (the original vaccine) was used to end smallpox epidemics. Poliomyelitis, mumps, measles, rubella, and chickenpox are prevented with childhood vaccines that contain live, replicating ..
  4. Reconstitution of Poliovirus and HCV RNA Replication Complexes on Membranes
    JENNIFER BARBARA PTACEK; Fiscal Year: 2010
    ..Although a vaccine exists to prevent poliovirus infection and the development of poliomyelitis, a vaccine has not yet been developed for numerous other positive-strand RNA viruses, including HCV, the ..
  5. Oral Polio Vaccine Circulation in Mexico
    Stephanie B Troy; Fiscal Year: 2013
    ..stopped abruptly, there would be a real threat of the OPV still in circulation causing outbreaks of paralytic poliomyelitis among the youngest, unvaccinated children...
  6. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..Subsequent to the virtual eradication of poliomyelitis, GBS is now considered the leading cause of acute flaccid paralysis in Western countries (1) with a reported ..
  7. Infectious Diseases and Child Health in Pakistan Research Training Program.
    Anita K M Zaidi; Fiscal Year: 2013
    ..Pakistan also harbours the highest numbers of poliomyelitis cases in the world, threatening global eradication goals...
  8. Enterovirus RNA Translation and Replication
    David Barton; Fiscal Year: 2009
    ..human enteroviruses cause a diverse spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of neonates...
  9. PICORNAVIRUS MOLECULAR BIOLOGY
    Eckard Wimmer; Fiscal Year: 2013
    ..These infections lead to a variety of diseases ranging from the mild (common cold) to the serious (poliomyelitis). In spite of research for many years the details of most steps in the life cycle of PV remain unknown...
  10. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010
    ..Diseases associated with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold...
  11. GENETIC ANALYSIS OF PICORNAVIRUS RNA REPLICATION IN VIVO
    JAMES FLANEGAN; Fiscal Year: 2006
    ..Some of the diseases associated with these viruses include meningitis, encephalitis, poliomyelitis, myocarditis, respiratory infections and hepatitis...
  12. CONFERENCE ON POSITIVE-STRAND RNA VIRUSES
    MARGO BRINTON; Fiscal Year: 1992
    ..Human pathology resulting from positive-strand RNA virus infections includes encephalitis, poliomyelitis, heart disease, hepatitis, the common cold, gastroenteritis, hemorrhagic fever, and birth defects...
  13. EUROPIC america 2002: a conference for picornaviruses
    Eckard Wimmer; Fiscal Year: 2002
    ..The over will discuss the difficulties (circulation of vaccine strains, recent outbreak of poliomyelitis in the Western Hemisphere) that have emerged during the current, historic effect to globally eradicate ..
  14. CONFERENCE ON POSITIVE-STRAND RNA VIRUSES
    MARGO BRINTON; Fiscal Year: 2001
    ..Human encephalitis, poliomyelitis, heart disease, hepatitis, the common cold, gastroenteritis, haemorrhagic fever, eye infections, and birth ..
  15. STRUCTURE OF POLIOVIRUS/ANTIVIRAL DRUG COMPLEXES
    JAMES HOGLE; Fiscal Year: 1991
    ..induced common cold (which account for 80% of the colds in the United States) and for early intervention in poliomyelitis and coxsackievirus induced diseases...
  16. LDV-INDUCED GENETICALLY RESTRICTED CNS DISEASE
    MARGO BRINTON; Fiscal Year: 1991
    ..in the mice they infect, one isolate, LDV-C, efficiently induces two distinct host strain specific diseases, poliomyelitis in C58 and AKR mice and meningitis and white matter inflammation in C57BR/cd mice...
  17. Structual Analysis of Enterovirus Cell Entry Pathways
    JAMES HOGLE; Fiscal Year: 2002
    ..These viruses are responsible for a variety of human diseases including: common colds, summer flu, poliomyelitis, encephalitis, meningitis, and a variety of cardiomyopathies...
  18. TRANSLATION-INHIBITION OF HEPATITIS C AND POLIO VIRUSES
    Asim Dasgupta; Fiscal Year: 2003
    ..and Flaviviruses encompass a large variety of medically important human viruses which include those inducing poliomyelitis (poliovirus), infectious (Hep...
  19. LOGIC CONTROLLED ELECTROMECHANICAL FREE KNEE ORTHOSIS
    Kenton Kaufman; Fiscal Year: 2000
    ..This orthosis will be useful for patients with poliomyelitis, spinal cord injuries, myopathic disorders, congenital spinal defects, and acquired paralysis due to ..
  20. Evolution of Human C-cluster Enteroviruses
    Eckard Wimmer; Fiscal Year: 2003
    ..Enterovirus, that are characterized by closely related genotypes but vastly different pathogenic properties (poliomyelitis vs. respiratory disease)...
  21. LDH VIRUS/AKR MULV INTERACTION IN POLIOMYELITIS OF MICE
    PETER PLAGEMANN; Fiscal Year: 1991
    ..We anticipate that the concepts developed in our study of the interaction of two viruses in motor neuron disease may have more general applicability to other human and animal diseases...
  22. POLIOVIRUS USING INFECTIOUS VIRAL CDNA CLONES
    VINCENT RACANIELLO; Fiscal Year: 1992
    ..Another series of experiments employ a mouse model for poliomyelitis to identify and study viral functions essential for production of disease...
  23. SPEECH BREATHING KINEMATICS ACROSS THE HUMAN LIFE SPAN
    THOMAS HIXON; Fiscal Year: 1991
    ..should extend to various disorders caused by neuromotor dysfunction, including cerebral palsy, spinal cord injury, poliomyelitis, myasthenia gravis, spinal muscular atrophy, peripheral neuropathy, muscular dystrophy, and others.
  24. WELLNESS FOR WOMEN WITH POLIO: HOLISTIC PROGRAM MODEL
    DENISE TATE; Fiscal Year: 1999
    ..200 subjects age 41-65 will be selected from a pool of women registered with a history of paralytic poliomyelitis who live in lower Michigan and Northern Ohio...
  25. Stem Cell Therapy for Motoneuron Degeneration
    Ping Wu; Fiscal Year: 2006
    ..data will provide a beginning assessment of the use of stem cell therapy for axotomy derived motoneuron loss and hopefully give insights into treatment of diseases such as amyotrophic lateral sclerosis and poliomyelitis.
  26. FUNCTION OF POLIOVIRUS RECEPTOR ON BLOOD CELLS
    MARION FREISTADT; Fiscal Year: 1999
    ..Despite the control of poliomyelitis in this country through the use of safe vaccines against poliovirus (PV; an enteric picornavirus), polio ..
  27. MOTOR NEURON DISEASE--A PROGRAM PROJECT
    Raymond Roos; Fiscal Year: 2002
    ..of the Program Project and involves experimental treatments, studies of sporadic and familial MND, and post-poliomyelitis syndrome; Core B- Administrative core...
  28. A Dynamic Disability Specific Physical Activity Scale
    Barth Riley; Fiscal Year: 2006
    ..e., spinal cord injury, stroke, poliomyelitis, and multiple sclerosis). Data will be analyzed using a Rasch partial credit measurement model...
  29. EFFECTS OF LONG-TERM USE OF PARTIALLY DENERVATED MUSCLE
    BRUCE PACHTER; Fiscal Year: 1991
    ..chronic muscle overuse in patients with a neuronal deficit leading to partially denervated muscles in unclear, poliomyelitis is just one of the many neurogenic disorders which produce a neuronal deficit and partially denervated muscles...
  30. IGF-I/ALS Trial
    Eric Sorenson; Fiscal Year: 2007
    ..The preliminary data from our prior trial allows design of a phase III treatment trial that will yield a definitive result about the treatment effect of IGF-I. ..
  31. QUANTITATIVE FUNCTION IN MOTOR NEURON DISEASE
    Eric Sorenson; Fiscal Year: 2004
    ..will study quantitative neuromuscular function longitudinally in a cohort of patients with prior paralytic poliomyelitis and in ALS...
  32. HEALTH PROMOTION AND QUALITY OF LIFE IN CHRONIC ILLNESS
    Alexa Stuifbergen; Fiscal Year: 2009
    ..Longitudinal data will be analyzed with hierarchical linear models (HIM) and structural equation modeling techniques. ..
  33. Health Promotion for Women with Fibromyalgia
    Alexa Stuifbergen; Fiscal Year: 2006
    ..Hierarchical linear modeling techniques will be used to determine the significance of group by time interactions across the four measurement periods. ..
  34. Computer-Assisted Cognitive Rehabilitation Intervention for Persons with MS
    Alexa K Stuifbergen; Fiscal Year: 2010
    ..The proposed study will test a computer-assisted cognitive rehabilitation intervention that is designed to improve both cognitive performance and cognitive competence for functioning in everyday life. ..
  35. Role of CNS CD4+ T cells in TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  36. Enterovirus persistence in myocarditis
    Nora Chapman; Fiscal Year: 2003
    ....
  37. ANTI-HIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 2003
    ..We believe that these new, novel antigen delivery systems and processing methods will be highly efficient at inducing a broad spectrum of anti-HIV-1 T cell responses in ART patients. ..
  38. Short Tandem Repeat Polymorphisms in Cytomegalovirus
    James Bale; Fiscal Year: 2003
    ..Characterizing HCM' strains by STR analysis will facilitate future studies of HCMV evolution and will provide a novel means t to fingerprint HCMV strains. ..
  39. Host factors involved in viral RNA recombination
    Peter Nagy; Fiscal Year: 2006
    ..Knowledge of recombination promises untold health benefits by providing means to limit virus infections and to develop safer vaccines. ..
  40. EARLY STAGES OF INFECTION BY NONENVELOPED VIRUSES
    Marie Chow; Fiscal Year: 2002
    ..It is aticipated that the studies will provide the biochemical and biophysical make-up of the channel structure and allow the applicants to build a general model of the early stages of infection by nonenveloped viruses. ..
  41. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
  42. POLIOVIRUS USING INFECTIOUS VIRAL CDNA CLONE
    VINCENT RACANIELLO; Fiscal Year: 2002
    ..The results of these experiments will contribute to the long term goal of this research, which is to provide a complete description of the replication and pathogenesis of a human viral pathogen. ..
  43. PATHOLOGICAL MECHANISMS OF DEMYELINATION
    Thomas Lane; Fiscal Year: 2002
    ..Together, these studies will provide insight into the complex immunological mechanisms involved in CNS demyelinating disease and allow a better understanding of the pathological mechanisms which exist in human demyelinating disease. ..
  44. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  45. Transgenic Mouse Model for Echovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2004
    ..of the poliovirus receptor, Pvr, was essential for the establishment of a transgenic mouse model for poliomyelitis. Although a great deal is known about the pathogenesis of poliovirus infection, relatively little is ..
  46. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  47. Dendritic Cell-Based Immunotherapy for HIV Infection
    Charles Rinaldo; Fiscal Year: 2005
    ..We believe that this novel immunotherapy strategy ideally fulfills the intent of the NIAID Integrated Preclinical/Clinical Program. ..
  48. Human Papillovirus Testing in Adolescents
    Jessica Kahn; Fiscal Year: 2006
    ..Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls. ..
  49. The Influence of Nutrition on Influenza Virus Infection
    Melinda Beck; Fiscal Year: 2004
    ..abstract_text> ..
  50. INFLUENZA VIRUS RIBONUCLEOPROTEINS (RNP)
    Peter Palese; Fiscal Year: 2006
    ..abstract_text> ..
  51. Dissecting the mechanism of viral RNA recombination
    Peter Nagy; Fiscal Year: 2004
    ..Knowledge of recombination promises untold health benefits by providing means to limit virus infections and safer vaccines. ..
  52. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  53. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  54. Nutrition, Viral Mutation and Host Defense
    Melinda Beck; Fiscal Year: 2007
    ..abstract_text> ..
  55. Stringent response and bmp expression in B. burgdorferi
    Felipe Cabello; Fiscal Year: 2007
    ..burgdorferi from a descriptive paradigm to a paradigm framed by mechanistic and causal interpretations. ..
  56. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..The data acquired could provide new insights and therapeutic intervention strategies for monocyte BBB trafficking during progressive HIV-1 infection in brain tissue. ..
  57. Development of Guinea Pig as Mamalian for Influenza Virus Transmission
    Peter Palese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. Modeling inter-rater agreement using mixed models
    Donald Edwards; Fiscal Year: 2007
    ..User-friendly software to fit the proposed models and measure of agreement will be developed and made publicly available. [unreadable] [unreadable] [unreadable]..
  59. Enterovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2007
    b>Poliomyelitis is an acute infection of the central nervous system cause by poliovirus. Poliovirus is an important human pathogen, yet our understanding of how the virus causes disease is incomplete...
  60. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
    ..unreadable] [unreadable]..