rocky mountain spotted fever

Summary

Summary: An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.

Top Publications

  1. ncbi Rocky Mountain spotted fever--changing ecology and persisting virulence
    J Stephen Dumler
    Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 353:551-3. 2005
  2. pmc Novel spotted fever group rickettsiosis, Brazil
    Mariana G Spolidorio
    University of Sao Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 16:521-3. 2010
  3. ncbi Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:805-11. 2004
  4. pmc Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group
    Gustavo Valbuena
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Pathol 163:1357-69. 2003
  5. ncbi Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Infect Dis 47:1188-96. 2008
  6. ncbi Rocky mountain spotted fever in the United States, 1997-2002
    Alice S Chapman
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30033, USA
    Ann N Y Acad Sci 1078:154-5. 2006
  7. pmc Experimental infection of Amblyomma aureolatum ticks with Rickettsia rickettsii
    Marcelo B Labruna
    Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 17:829-34. 2011
  8. ncbi Features of Brazilian spotted fever in two different endemic areas in Brazil
    Rodrigo N Angerami
    Núcleo de Vigilância Epidemiológica, Hospital de Clinicas, Universidade Estadual de Campinas, SP, Brazil
    Ticks Tick Borne Dis 3:346-8. 2012
  9. ncbi Experimental infection of capybaras Hydrochoerus hydrochaeris by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense
    Celso E Souza
    SUCEN Superintendência de Controle de Endemias, Laboratório de Carrapatos, Mogi Guaçu, SP, Brazil
    Vet Parasitol 161:116-21. 2009
  10. pmc Eschar-associated spotted fever rickettsiosis, Bahia, Brazil
    Nanci Silva
    Medicine and Public Health School of Bahia, Salvador, Brazil
    Emerg Infect Dis 17:275-8. 2011

Detail Information

Publications181 found, 100 shown here

  1. ncbi Rocky Mountain spotted fever--changing ecology and persisting virulence
    J Stephen Dumler
    Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 353:551-3. 2005
  2. pmc Novel spotted fever group rickettsiosis, Brazil
    Mariana G Spolidorio
    University of Sao Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 16:521-3. 2010
    ..Molecular analysis of skin samples indicated the agent was a novel spotted fever group strain closely related to Rickettsia africae, R. parkeri, and R. sibirica...
  3. ncbi Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:805-11. 2004
    ..Only Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, has been definitively associated with disease in humans in the United States...
  4. pmc Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group
    Gustavo Valbuena
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Pathol 163:1357-69. 2003
    b>Rocky Mountain spotted fever and other related diseases are systemic infections caused by rickettsiae...
  5. ncbi Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Infect Dis 47:1188-96. 2008
    ..parkeri and comment on distinctions between R. parkeri rickettsiosis and other United States rickettsioses...
  6. ncbi Rocky mountain spotted fever in the United States, 1997-2002
    Alice S Chapman
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30033, USA
    Ann N Y Acad Sci 1078:154-5. 2006
    The increased incidence of Rocky Mountain spotted fever (RMSF) in 1997-2002 compared with previous years may be related to enhanced awareness and reporting of RMSF as well as changes in human-vector interaction...
  7. pmc Experimental infection of Amblyomma aureolatum ticks with Rickettsia rickettsii
    Marcelo B Labruna
    Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 17:829-34. 2011
    ..infected Amblyomma aureolatum ticks with the bacterium Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever (RMSF). These ticks are a vector for RMSF in Brazil. R...
  8. ncbi Features of Brazilian spotted fever in two different endemic areas in Brazil
    Rodrigo N Angerami
    Núcleo de Vigilância Epidemiológica, Hospital de Clinicas, Universidade Estadual de Campinas, SP, Brazil
    Ticks Tick Borne Dis 3:346-8. 2012
    ....
  9. ncbi Experimental infection of capybaras Hydrochoerus hydrochaeris by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense
    Celso E Souza
    SUCEN Superintendência de Controle de Endemias, Laboratório de Carrapatos, Mogi Guaçu, SP, Brazil
    Vet Parasitol 161:116-21. 2009
    ..Our results indicate that capybaras act as amplifier host of R. rickettsii for A. cajennense ticks in Brazil...
  10. pmc Eschar-associated spotted fever rickettsiosis, Bahia, Brazil
    Nanci Silva
    Medicine and Public Health School of Bahia, Salvador, Brazil
    Emerg Infect Dis 17:275-8. 2011
    ..The etiologic agent is most related to Rickettsia parkeri, R. africae, and R. sibirica and probably widely distributed from Sao Paulo to Bahia in the Atlantic Forest...
  11. ncbi Rocky Mountain spotted fever in Arizona: documentation of heavy environmental infestations of Rhipicephalus sanguineus at an endemic site
    William L Nicholson
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Mail Stop G 13, 1600 Clifton Road, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1078:338-41. 2006
    A recent epidemiologic investigation identified 16 cases and 2 deaths from Rocky Mountain spotted fever (RMSF) in two eastern Arizona communities...
  12. ncbi Tick-borne diseases in North Carolina: is "Rickettsia amblyommii" a possible cause of rickettsiosis reported as Rocky Mountain spotted fever?
    Charles S Apperson
    Department of Entomology, North Carolina State University, Raleigh, North Carolina 27695 7647, USA
    Vector Borne Zoonotic Dis 8:597-606. 2008
    Cases of Rocky Mountain spotted fever (RMSF) in North Carolina have escalated markedly since 2000. In 2005, we identified a county in the Piedmont region with high case numbers of RMSF...
  13. pmc Rickettsia parkeri in Amblyomma triste from Uruguay
    Jose M Venzal
    Departamento de Parasitología Veterinaria, Facultad de Veterinaria, Universidad de la Republica, Montevideo, Uruguay
    Emerg Infect Dis 10:1493-5. 2004
    ..Rickettsia parkeri was detected in A. triste, which suggests that this species could be considered a pathogenic agent responsible for human rickettsioses in Uruguay...
  14. ncbi Evaluation of conventional and real-time PCR assays for detection and differentiation of Spotted Fever Group Rickettsia in dog blood
    L Kidd
    Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA
    Vet Microbiol 129:294-303. 2008
    ..They may also facilitate the discovery of novel SFG Rickettsia infecting dogs, and in the investigation of dogs as sentinels for emerging rickettsioses...
  15. ncbi Family cluster of Rocky Mountain spotted fever
    T F Jones
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 28:853-9. 1999
    Soon after a patient from Tennessee died of Rocky Mountain spotted fever (RMSF), several family members developed symptoms suggestive of the disease and were treated presumptively for RMSF...
  16. pmc A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever
    S Vishwanath
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    Infect Immun 58:646-53. 1990
    There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present ..
  17. ncbi Serologic evidence for exposure to Rickettsia rickettsii in eastern Arizona and recent emergence of Rocky Mountain spotted fever in this region
    Linda J Demma
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Atlanta, Georgia, USA
    Vector Borne Zoonotic Dis 6:423-9. 2006
    During 2002 through 2004, 15 patients with Rocky Mountain spotted fever (RMSF) were identified in a rural community in Arizona where the disease had not been previously reported...
  18. ncbi [Rocky Mountain spotted fever in Brazil]
    Fernando del Sá DelFiol
    Programa de Mestrado em Ciências Farmacêuticas, Universidade de Sorocaba, Cerquilho, SP, Brasil
    Rev Panam Salud Publica 27:461-6. 2010
    ..Since early diagnosis and the adequate drug treatment are key to a good prognosis, health care professionals must be better prepared to recognize and treat spotted fever...
  19. pmc Characterization of spotted fever group rickettsiae in flea and tick specimens from northern Peru
    Patrick J Blair
    U S Naval Medical Research Center Detachment, Lima, Peru
    J Clin Microbiol 42:4961-7. 2004
    ..Furthermore, molecular analysis of sequences derived from the two separate species of hard ticks identified a possibly novel member of the SFG rickettsiae...
  20. ncbi Spatial clustering by disease severity among reported Rocky Mountain spotted fever cases in the United States, 2001-2005
    Jennifer Zipser Adjemian
    Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30030, USA
    Am J Trop Med Hyg 80:72-7. 2009
    b>Rocky Mountain spotted fever (RMSF) occurs throughout much of the United States, ranging in clinical severity from moderate to fatal infection...
  21. pmc Trends in clinical diagnoses of Rocky Mountain spotted fever among American Indians, 2001-2008
    Arianne M Folkema
    Division of High Consequence Pathogens and Pathology, and Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 86:152-8. 2012
    American Indians are at greater risk for Rocky Mountain spotted fever (RMSF) than the general U.S. population...
  22. ncbi Experimental infection of the tick Amblyomma cajennense, Cayenne tick, with Rickettsia rickettsii, the agent of Rocky Mountain spotted fever
    J F Soares
    Faculty of Veterinary Medicine, Department of Preventive Veterinary Medicine and Animal Health, University of Sao Paulo, Sao Paulo, SP, Brazil
    Med Vet Entomol 26:139-51. 2012
    ..Our results indicate that A. cajennense have a low efficiency to maintain R. rickettsii for successive generations, as R. rickettsii-infection rates should decline drastically throughout the successive tick generations...
  23. ncbi Spotted fever group Rickettsia infecting ticks (Acari: Ixodidae) in the state of Santa Catarina, Brazil
    Alessandra Pereira Medeiros
    Departamento de Medicina Veterinaria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Lages, SC, Brasil
    Mem Inst Oswaldo Cruz 106:926-30. 2011
    ..parkeri strain Atlantic rainforest was recently shown to have caused two cases of human spotted fever in other states of Brazil, the role of this rickettsial agent as a possible etiological agent of spotted fever in SC is discussed...
  24. ncbi Physician knowledge of the diagnosis and management of Rocky Mountain spotted fever: Mississippi, 2002
    M O'REILLY
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 990:295-301. 2003
    b>Rocky Mountain spotted fever (RMSF), a tick-borne illness that has its highest incidence in the south central and southeastern United States, is often a diagnostic challenge, as patients frequently present with nonspecific symptoms during ..
  25. ncbi Epidemiology of Brazilian spotted fever in the Atlantic Forest, state of São Paulo, Brazil
    Maria Ogrzewalska
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Universidade de Sao Paulo, Sao Paulo, Brazil
    Parasitology 139:1283-300. 2012
    ..However, not all forest patches in the southern part of the SPMA were shown to be associated with BSF endemism...
  26. pmc Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of São Paulo, Brazil, where Brazilian spotted fever is endemic
    Marcelo B Labruna
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    J Clin Microbiol 42:90-8. 2004
    ..These results do not support the role of A. cooperi in the ecology of R. rickettsii in the area studied, but they add two more species of rickettsiae to the poorly developed list of species occurring in ticks in South America...
  27. ncbi Rocky Mountain spotted fever
    Filipe Dantas-Torres
    Department of Immunology, Centre of Research Aggeu Magalhães, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil
    Lancet Infect Dis 7:724-32. 2007
    b>Rocky Mountain spotted fever (RMSF) is a life-threatening disease caused by Rickettsia rickettsii, an obligately intracellular bacterium that is spread to human beings by ticks...
  28. ncbi Rocky Mountain spotted fever: a clinician's dilemma
    Edwin J Masters
    Department of Pediatrics, St Francis Medical Center and Southeast Missouri Hospital, Cape Girardeau, MO, USA
    Arch Intern Med 163:769-74. 2003
    b>Rocky Mountain spotted fever is still the most lethal tick-vectored illness in the United States...
  29. ncbi Rocky Mountain Spotted Fever as a cause of macular star figure
    Michael S Vaphiades
    UAB Department of Ophthalmology, Suite 601, 700 South 18th Street, Birmingham, AL 35233, USA
    J Neuroophthalmol 23:276-8. 2003
    ..The serum Rickettsia rickettsii antibody test was markedly positive, establishing a diagnosis of Rocky Mountain Spotted Fever (RMSF) as the cause of the ophthalmic findings...
  30. ncbi [Rickettsial spotted fever in the Paraná Delta. An emerging disease]
    Alfredo Seijo
    Servicio de Zoonosis, Hospital de Infecciosas F J Muñiz, Buenos Aires, Argentina
    Medicina (B Aires) 67:723-6. 2007
    ..Several considerations relating to the identity of the rickettsial species and tick vector are discussed, including the possibility that this patient's illness may have been caused by Rickettsia parkeri...
  31. ncbi Rickettsial infections of dogs, horses and ticks in Juiz de Fora, southeastern Brazil, and isolation of Rickettsia rickettsii from Rhipicephalus sanguineus ticks
    R C Pacheco
    Department of Basic Sciences and Animal Production, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiaba, MT, Brazil
    Med Vet Entomol 25:148-55. 2011
    ..Overall, the results of the present study indicate a potential risk for transmission of R. rickettsii to humans by Rh. sanguineus, an occurrence yet to be documented in Brazil...
  32. ncbi Infrequency of Rickettsia rickettsii in Dermacentor variabilis removed from humans, with comments on the role of other human-biting ticks associated with spotted fever group Rickettsiae in the United States
    Ellen Y Stromdahl
    Entomological Sciences Program, US Army Public Health Command, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Vector Borne Zoonotic Dis 11:969-77. 2011
    ..in a small number of samples, but no ticks were found positive for Rickettsia rickettsii, the agent of Rocky Mountain spotted fever (RMSF) until May 2009, when it was detected in one D. variabilis male removed from a child in Maryland...
  33. ncbi Rocky Mountain spotted fever from an unexpected tick vector in Arizona
    Linda J Demma
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, The Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 353:587-94. 2005
    b>Rocky Mountain spotted fever is a life-threatening, tick-borne disease caused by Rickettsia rickettsii. This disease is rarely reported in Arizona, and the principal vectors, Dermacentor species ticks, are uncommon in the state...
  34. pmc Rocky Mountain spotted fever, Colombia
    Marylin Hidalgo
    Instituto Nacional de Salud, Bogota, Colombia
    Emerg Infect Dis 13:1058-60. 2007
    We investigated 2 fatal cases of Rocky Mountain spotted fever that occurred in 2003 and 2004 near the same locality in Colombia where the disease was first reported in the 1930s...
  35. pmc Fatal spotted fever rickettsiosis, Minas Gerais, Brazil
    Márcio Antonio Moreira Galvâo
    Universidade Federal de Ouro Preto, Minas Gerais, Brazil
    Emerg Infect Dis 9:1402-5. 2003
    ..The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests...
  36. pmc Spotted-fever group Rickettsia in Dermacentor variabilis, Maryland
    Nicole C Ammerman
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Emerg Infect Dis 10:1478-81. 2004
    ..8%, as determined by polymerase chain reaction. Single strand conformational polymorphism (SSCP) analysis followed by sequencing indicated that all infections represented a single rickettsial taxon, Rickettsia montanensis...
  37. pmc Fatal human infection with Rickettsia rickettsii, Yucatán, Mexico
    Jorge E Zavala-Castro
    Universidad Auttónoma de Yucatán, Merida Yucatan, Mexico
    Emerg Infect Dis 12:672-4. 2006
    ..The diagnosis of R. rickettsii infection was established by immunohistochemistry and specific polymerase chain reaction...
  38. ncbi The expanding spectrum of eschar-associated rickettsioses in the United States
    W Chad Cragun
    Dermatology Service, San Antonio Military Medical Center, 2200 Bergquist Dr, Ste 1, Lackland AFB, TX 78236 9908, USA
    Arch Dermatol 146:641-8. 2010
    ..Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tick-borne SFG rickettsiosis...
  39. ncbi Experimental infection of Rhipicephalus sanguineus ticks with the bacterium Rickettsia rickettsii, using experimentally infected dogs
    Eliane M Piranda
    Curso de Medicina Veterinaria, Escola Superior Batista do Amazonas, Manaus, Amazonas, Brazil
    Vector Borne Zoonotic Dis 11:29-36. 2011
    ..It appears that Rh. sanguineus, in the absence of horizontal transmission, would not maintain Ri. rickettsii through successive generations, possibly because of low filial infection rates...
  40. ncbi Canine Rocky Mountain Spotted fever: a retrospective study of 30 cases
    A M Gasser
    Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Am Anim Hosp Assoc 37:41-8. 2001
    b>Rocky Mountain spotted fever (RMSF) was diagnosed in 30 dogs examined at North Carolina State University, Veterinary Teaching Hospital between 1984 and 1997. Historical, physical examination, and laboratory abnormalities were reviewed...
  41. pmc Amblyomma imitator ticks as vectors of Rickettsia rickettsii, Mexico
    Karla A Oliveira
    University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0609, USA
    Emerg Infect Dis 16:1282-4. 2010
    ..Sequence analyses of 17-kD common antigen and outer membrane protein A and B gene fragments showed to it to be R. rickettsii, which suggested a potential new vector for this bacterium...
  42. pmc Rickettsiae in Gulf Coast ticks, Arkansas, USA
    Rebecca Trout
    University of Arkansas, Fayetteville, Arkansas 72701, USA
    Emerg Infect Dis 16:830-2. 2010
    ..Of the screened ticks, 30% had PCR amplicons consistent with Rickettsia parkeri or Candidatus Rickettsia amblyommii...
  43. ncbi Assessing the magnitude of fatal Rocky Mountain spotted fever in the United States: comparison of two national data sources
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, and Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 67:349-54. 2002
    To assess the magnitude of fatal Rocky Mountain spotted fever (RMSF) and to evaluate the completeness of national surveillance for this occurrence from 1983 through 1998, two independent sources of RMSF mortality data were analyzed using ..
  44. ncbi Experimental infection of opossums Didelphis aurita by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense
    Mauricio C Horta
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Universidade de Sao Paulo, Sao Paulo, Brasil
    Vector Borne Zoonotic Dis 9:109-18. 2009
    ..The study demonstrated that R. rickettsii was capable of infecting opossums without causing illness and developing rickettsemia capable of causing infection in guinea pigs and ticks, although the infection rate in ticks was low...
  45. ncbi New epidemiological data on Brazilian spotted fever in an endemic area of the state of São Paulo, Brazil
    Jonas Moraes-Filho
    Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Vector Borne Zoonotic Dis 9:73-8. 2009
    ..sanguineus in the epidemiology of R. rickettsii, corroborating previous findings in Mexico and the United States, where R. sanguineus has been implicated in the transmission of R. rickettsii to humans...
  46. ncbi Spotted fever in Brazil: a seroepidemiological study and description of clinical cases in an endemic area in the state of São Paulo
    E R de Lemos
    Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil
    Am J Trop Med Hyg 65:329-34. 2001
    ..Twenty-two (4.2%) of these samples demonstrated titers > or = 1:64. The results indicate that Brazilian spotted fever is endemic within this region of Brazil...
  47. ncbi Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals
    Alice S Chapman
    National Center for Infectious Diseases, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 55:1-27. 2006
    ..Viral and Rickettsial Zoonoses Branch, in consultation with 11 clinical and academic specialists of Rocky Mountain spotted fever, human granulocytotropic anaplasmosis, and human monocytotropic ehrlichiosis, developed guidelines to ..
  48. pmc Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain spotted fever in dogs
    E B Breitschwerdt
    Department of Companion Animal, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Antimicrob Agents Chemother 43:813-21. 1999
    ..and trovafloxacin to that of the current antibiotic standard, doxycycline, for the treatment of Rocky Mountain spotted fever. Clinicopathologic parameters, isolation of rickettsiae in tissue culture, and PCR amplification of ..
  49. pmc Rickettsial pathogens and their arthropod vectors
    A F Azad
    University of Maryland School of Medicine, Baltimore, USA
    Emerg Infect Dis 4:179-86. 1998
    ..This article examines the common features of the host-pathogen relationship and of the arthropod vectors of the typhus and spotted fever group rickettsiae...
  50. ncbi Prevalence of rickettsia-like organisms and spotted fever group rickettsiae in ticks (Acari: Ixodidae) from Zimbabwe
    L Beati
    Unite des Rickettsies, Faculte de Medecine, Marseille, France
    J Med Entomol 32:787-92. 1995
    ....
  51. ncbi Rocky Mountain spotted fever in the United States, 1997-2002
    Alice S Chapman
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Vector Borne Zoonotic Dis 6:170-8. 2006
    b>Rocky Mountain spotted fever (RMSF) is the most commonly reported fatal tick-borne disease in the United States...
  52. ncbi Rocky Mountain spotted fever and pregnancy: a case report and review of the literature
    S P Stallings
    Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Obstet Gynecol Surv 56:37-42. 2001
    ..rash occurring 1 to 2 weeks after a tick bite in an endemic area should raise suspicions for Rocky Mountain spotted fever (RMSF)...
  53. ncbi Rocky Mountain spotted fever
    N L Lacz
    UMDNJ New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Eur Acad Dermatol Venereol 20:411-7. 2006
    b>Rocky Mountain spotted fever (RMSF) is an unusual but important dermatological condition to identify without hesitation...
  54. ncbi What's new in Rocky Mountain spotted fever?
    Luke F Chen
    Division of Infectious Diseases and International Health, Duke University Medical Center, DUMC Box 3824, Durham, NC, 27710, USA
    Infect Dis Clin North Am 22:415-32, vii-viii. 2008
    b>Rocky Mountain spotted fever (RMSF) remains an important illness despite an effective therapy because it is difficult to diagnose and is capable of producing a fatal outcome. The pathogenesis of RMSF remains, in large part, an enigma...
  55. ncbi Serosurvey of Rickettsia spp. in dogs and humans from an endemic area for Brazilian spotted fever in the State of São Paulo, Brazil
    Adriano Pinter
    Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, Brasil
    Cad Saude Publica 24:247-52. 2008
    ..parkeri, R. felis, or R. bellii. Our serological results showed that dogs are important sentinels for the presence of R. rickettsii in areas where the tick A. aureolatum is the main vector of Brazilian spotted fever...
  56. ncbi Rocky Mountain spotted fever in the USA: a benign disease or a common diagnostic error?
    Didier Raoult
    Lancet Infect Dis 8:587-9. 2008
  57. ncbi Developmental profiles in tick water balance with a focus on the new Rocky Mountain spotted fever vector, Rhipicephalus sanguineus
    J A Yoder
    Department of Biology, Wittenberg University, Springfield, Ohio 45501, USA
    Med Vet Entomol 20:365-72. 2006
    ..tick, or kennel tick, Rhipicephalus sanguineus (Latreille) (Acari: Ixodidae) is a competent vector of Rocky Mountain spotted fever in the U.S.A...
  58. ncbi Short report: concurrent Rocky Mountain spotted fever in a dog and its owner
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 66:197-9. 2002
    A sequential occurrence of Rocky Mountain spotted fever (RMSF) in a dog and its owner is described. Diagnosis of RMSF in the animal guided subsequent testing for and diagnosis of the same disease in the human patient...
  59. ncbi Central nervous system dysfunction associated with Rocky Mountain spotted fever infection in five dogs
    Jessica S Mikszewski
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6010, USA
    J Am Anim Hosp Assoc 41:259-66. 2005
    ..northeastern United States were presented with clinical signs of neurological disease associated with Rocky Mountain spotted fever (RMSF) infection. Four of the five dogs had vestibular system dysfunction...
  60. ncbi Implications of presumptive fatal Rocky Mountain spotted fever in two dogs and their owner
    Brigid N Elchos
    Mississippi Department of Health, PO Box 1700, Jackson, MS 39215, USA
    J Am Vet Med Assoc 223:1450-2, 1433. 2003
    ..The dog was not examined by a veterinarian, but Rocky Mountain spotted fever (RMSF) was suspected on the basis of clinical signs...
  61. pmc Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov
    Pierre Edouard Fournier
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    J Clin Microbiol 41:5456-65. 2003
    ..3% for the ompA and ompB genes and gene D, respectively. By use of our classification scheme, "Rickettsia heilongjiangii" belongs to a new species for which we officially propose the name Rickettsia heilongjiangensis sp. nov...
  62. ncbi An outbreak of Rocky Mountain Spotted Fever associated with a novel tick vector, Rhipicephalus sanguineus, in Arizona, 2004: preliminary report
    Linda J Demma
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Mail Stop G 13, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 1078:342-3. 2006
    ..This study describes preliminary results of an investigation of RMSF in Arizona associated with the brown dog tick, Rhipicephalus sanguineus. High numbers of dogs and heavy infestations of ticks created a situation leading to human disease...
  63. ncbi Experimental infection of dogs with a Brazilian strain of Rickettsia rickettsii: clinical and laboratory findings
    Eliane M Piranda
    Departamento de Parasitologia Animal, Instituto de Veterinaria, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Brasil
    Mem Inst Oswaldo Cruz 103:696-701. 2008
    The bacterium Rickettsia rickettsii is the etiological agent of an acute, severe disease called Rocky Mountain spotted fever in the United States or Brazilian spotted fever (BSF) in Brazil...
  64. ncbi Managing Rocky Mountain spotted fever
    Timothy D Minniear
    St Jude Children s Research Hospital, Department of Infectious Diseases, 262 Danny Thomas Place, Mail Stop 320, Memphis, TN 38105, USA
    Expert Rev Anti Infect Ther 7:1131-7. 2009
    b>Rocky Mountain spotted fever is caused by the tick-borne bacterium Rickettsia rickettsii. Symptoms range from moderate illness to severe illness, including cardiovascular compromise, coma and death...
  65. ncbi Laboratory-acquired Rocky Mountain spotted fever. The hazard of aerosol transmission
    C N Oster
    N Engl J Med 297:859-63. 1977
    Nine patients with laboratory-acquired Rocky Mountain spotted fever were seen during the period 1971 to 1976...
  66. ncbi Rocky Mountain spotted fever in Argentina
    Christopher D Paddock
    Infectious Disease Pathology Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 78:687-92. 2008
    We describe the first molecular confirmation of Rickettsia rickettsii, the cause of Rocky Mountain spotted fever (RMSF), from a tick vector, Amblyomma cajennense, and from a cluster of fatal spotted fever cases in Argentina. Questing A...
  67. pmc Rocky mountain spotted fever in the United States, 2000-2007: interpreting contemporary increases in incidence
    John J Openshaw
    Division of Viral and Rickettsial Diseases, National Center of Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Trop Med Hyg 83:174-82. 2010
    b>Rocky Mountain spotted fever (RMSF), a potentially fatal tick-borne infection caused by Rickettsia rickettsii, is considered a notifiable condition in the United States...
  68. pmc Evaluation of a PCR assay for quantitation of Rickettsia rickettsii and closely related spotted fever group rickettsiae
    Marina E Eremeeva
    School of Medicine, University of Maryland Baltimore, Baltimore, Maryland 21201 1559, USA
    J Clin Microbiol 41:5466-72. 2003
    ....
  69. ncbi Passive surveillance as an instrument to identify risk factors for fatal Rocky Mountain spotted fever: is there more to learn?
    James E Childs
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 66:450-7. 2002
    National surveillance for Rocky Mountain spotted fever (RMSF) dates from 1920; however, the collection of detailed epidemiologic, clinical, and laboratory data on RMSF by using case report forms began in 1970...
  70. pmc Rocky Mountain spotted fever, Panama
    Dora Estripeaut
    Hospital del Nino, Panama City, Panama
    Emerg Infect Dis 13:1763-5. 2007
    We describe a fatal pediatric case of Rocky Mountain spotted fever in Panama, the first, to our knowledge, since the 1950s...
  71. ncbi Rocky mountain spotted fever
    Byron L Lam
    Ann Ophthalmol (Skokie) 38:3-4. 2006
  72. ncbi Cross-protection between distantly related spotted fever group rickettsiae
    Hui Min Feng
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Vaccine 21:3901-5. 2003
    ....
  73. ncbi Rickettsia rickettsii: as virulent as ever
    David H Walker
    Am J Trop Med Hyg 66:448-9. 2002
  74. pmc Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
    Damon W Ellison
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 76:542-50. 2008
    Rickettsia rickettsii is an obligate intracellular pathogen that is the causative agent of Rocky Mountain spotted fever. To identify genes involved in the virulence of R. rickettsii, the genome of an avirulent strain, R...
  75. ncbi Spotted fever rickettsiosis in Coronel Fabriciano, Minas Gerais State
    Márcio Antonio Moreira Galvâo
    Departamento de Nutrição Clínica e Social, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil
    Rev Soc Bras Med Trop 36:479-81. 2003
    ..The serological results confirm the difficulty in the differential diagnosis of patients with symptoms of rickettsial diseases...
  76. ncbi Prevalence of antibodies against spotted fever group rickettsiae in a rural area of Colombia
    Marylin Hidalgo
    Grupo de Microbiologia, Instituto Nacional de Salud, Bogota, Colombia
    Am J Trop Med Hyg 77:378-80. 2007
    We recently rediscovered Rocky Mountain spotted fever in Villeta, Colombia, near the same locality (Tobia) where it was first recognized in 1937...
  77. ncbi Molecular characterization of Rickettsia rickettsii infecting dogs and people in North Carolina
    Linda Kidd
    TheScripps Research Institute, Department of Immunology, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1078:400-9. 2006
    b>Rocky Mountain spotted fever (RMST) is an important cause of morbidity and mortality in people and dogs in the United States. Disease manifestations are strikingly similar in both species, and illness in dogs can precede illness in people...
  78. ncbi Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs
    V L Hinrichsen
    Center for Vector-Borne Disease, University of Rhode Island, Kingston 02881, USA
    J Am Vet Med Assoc 218:1092-7. 2001
    ..Knowledge concerning tick distributions may be useful in predicting the pattern of disease associated with particular tick species and may aid diagnostic, prevention, and control efforts...
  79. ncbi Clinical and laboratory features, hospital course, and outcome of Rocky Mountain spotted fever in children
    Steven C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Pediatr 150:180-4, 184.e1. 2007
    To describe the clinical characteristics and course of children with laboratory-diagnosed Rocky Mountain spotted fever (RMSF) and to identify clinical findings independently associated with adverse outcomes of death or discharge with ..
  80. pmc Molecular typing of isolates of Rickettsia rickettsii by use of DNA sequencing of variable intergenic regions
    Sandor E Karpathy
    Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 45:2545-53. 2007
    Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, is found throughout the Americas, where it is associated with different animal reservoirs and tick vectors...
  81. ncbi Interactions of Rickettsia rickettsii with endothelial nuclear factor-kappaB in a "cell-free" system
    Sanjeev K Sahni
    Hematology Oncology Unit, Hemostasis and Thrombosis Program, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann N Y Acad Sci 990:635-41. 2003
  82. ncbi Rocky Mountain spotted fever
    Ronald D Warner
    Department of Family and Community Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430 0001, USA
    J Am Vet Med Assoc 221:1413-7. 2002
  83. ncbi [Emerging and reemerging rickettsiosis in an endemic area of Minas Gerais State, Brazil]
    Marcio A M Galvao
    Departamento de Nutrição Clínica e Social, Escola de Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, MG, 35400 000, Brasil
    Cad Saude Publica 18:1593-7. 2002
    ..81%), respectively. The results in schoolchildren and the presence of canine seroreactivity to Ehrlichiaspecies that are potentially pathogenic to humans suggests the risk of transmission of other Rickettsiaein the study area...
  84. ncbi Brazilian spotted fever: description of a fatal clinical case in the State of Rio de Janeiro
    Elba Regina Sampaio de Lemos
    Departamento de Virologia do Instituto Oswaldo Cruz da Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Rev Soc Bras Med Trop 35:523-5. 2002
    ..Serologic test in a serum sample, using an immunofluorescence assay, revealed reactive IgM/IgG...
  85. ncbi Antibodies reactive to Rickettsia rickettsii among children living in the southeast and south central regions of the United States
    Gary S Marshall
    Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY40202, USA
    Arch Pediatr Adolesc Med 157:443-8. 2003
    The reported annual incidence of Rocky Mountain spotted fever in the United States is 2.2 per million, but studies have suggested that human infection with Rickettsia rickettsii may be more common...
  86. ncbi Molecular detection of spotted fever group Rickettsia in Dermacentor silvarum from a forest area of northeastern China
    Wu Chun Cao
    Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, 20 Dong Da St, Fengtai District, Beijing 100071, People s Republic of China
    J Med Entomol 45:741-4. 2008
    ..sibirica and discovered a novel rickettsial agent in this area, the sequence of which was identical to that of DnS14 genotype Rickettsia previously reported in the former Soviet Union...
  87. ncbi Active immunisation against human tick-borne diseases
    Simona Bratu
    Infectious Diseases IIIE, VA NY Harbor Healthcare System, 800 Poly Place, Brooklyn, New York 11209, USA
    Expert Opin Biol Ther 2:187-95. 2002
    ..This review highlights vaccine information for Lyme borreliosis, tick-borne encephalitis (TBE), Rocky Mountain spotted fever, tularaemia, Query (Q) fever, Kyasanur Forest disease (KFD) and tick paralysis...
  88. pmc Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity
    Suresh G Joshi
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:4127-36. 2003
    ..The potentially fatal human infection caused by Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever, involves the vascular endothelium of various organ systems of the host...
  89. ncbi Ecology and epidemiology of spotted fever group Rickettsiae and new data from their study in Russia and Kazakhstan
    N V Rudakov
    Omsk Research Institute of Natural Foci Infections, Omsk, Russia
    Ann N Y Acad Sci 990:12-24. 2003
    ..Interference between rickettsiae with different virulence may affect its populations and levels of morbidity...
  90. ncbi Rickettsia rickettsii infection in the pine vole, Microtus pinetorum: kinetics of infection and quantitation of antioxidant enzyme gene expression by RT-PCR
    Marina E Eremeeva
    Viral and Rickettsial Zoonoses Branch, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 990:468-73. 2003
    ..rickettsii. Our results provide the first experimental evidence that R. rickettsii causes alteration(s) of the anti-oxidant system in vivo...
  91. ncbi [Fever that should not kill]
    Gustavo Valbuena
    Biomedica 27:321-4. 2007
  92. ncbi Rocky Mountain spotted fever: a review for the pediatrician
    Steven C Buckingham
    Department of Pediatrics, Division of Infectious Disease, University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
    Pediatr Ann 31:163-8. 2002
  93. pmc Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins
    Elena Rydkina
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Infect Immun 74:5067-74. 2006
    ..b>Rocky Mountain spotted fever and boutonneuse fever, due to Rickettsia rickettsii and R...
  94. ncbi [Study on spotted fever group Rickettsiae in Guangdong province]
    Jian Feng He
    Center for Disease Control and Prevention of Guandong Province, Guangzhou 510300, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:700-3. 2003
    ..To explore the existence of spotted fever group Rickettsiae (SFGR) in Guangdong province...
  95. pmc Lymph node hemophagocytosis in rickettsial diseases: a pathogenetic role for CD8 T lymphocytes in human monocytic ehrlichiosis (HME)?
    Kerry L Dierberg
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Infect Dis 6:121. 2006
    Human monocytic ehrlichiosis (HME) and Rocky Mountain spotted fever (RMSF) are caused by Ehrlichia chaffeensis and Rickettsia rickettsii, respectively...
  96. ncbi Prevalence of antibodies to spotted fever group rickettsiae in humans and domestic animals in a Brazilian spotted fever-endemic area in the state of São Paulo, Brazil: serologic evidence for infection by Rickettsia rickettsii and another spotted fever gro
    Mauricio C Horta
    Faculty of Veterinary Medicine, and Department of Parasitology, University of Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 71:93-7. 2004
    ..rickettsii, and one dog serum had antibodies against a Rickettsia species very closely related to R. africae. The latter may have been caused by infection with the recently identified COOPERI strain...
  97. ncbi Serologic survey of select infectious diseases in coyotes and raccoons in Nebraska
    Richard Bischof
    Nebraska Game and Parks Commission, 2200 North 33rd Street, Lincoln, Nebraska 68503 0370, USA
    J Wildl Dis 41:787-91. 2005
    ..For raccoons, antibodies were detected against CDV (33%), F. tularensis (38%), and three serovars of L. interrogans (11%)...
  98. ncbi Tick-borne infections in children: epidemiology, clinical manifestations, and optimal management strategies
    Steven C Buckingham
    Department of Pediatrics, Division of Infectious Disease, University of Tennessee Health Science Center and Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
    Paediatr Drugs 7:163-76. 2005
    ..Doxycycline is the antimicrobial treatment of choice for all patients, regardless of age, with Rocky Mountain spotted fever, human monocytic ehrlichiosis, or human granulocytic ehrlichiosis...
  99. ncbi [Rickettsia helvetica: an emerging tick-borne pathogen in Hungary and Europe]
    Tamás Sréter
    Országos Allategészségügyi Intézet, Bakteriológiai Fosztály
    Orv Hetil 146:2547-52. 2005
    ..A summary of the information available from Hungary and neighbouring countries on the prevalence of tick-borne encephalitis virus, Anaplasma, Borrelia, Francisella, Rickettsia and Babesia infections in I. ricinus is also presented...
  100. ncbi Tick-borne bacterial, rickettsial, spirochetal, and protozoal infectious diseases in the United States: a comprehensive review
    Jarrett R Amsden
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Pharmacotherapy 25:191-210. 2005
    ..Because pharmacists are the most accessible health care providers, they are often asked how to treat tick-borne diseases. Thus, practitioners should be familiar with the ticks that inhabit their locale...
  101. ncbi [Spotted fever group rickettsiosis on Awaji Island, Japan]
    K Kodama
    Department of Internal Medicine, Prefectural Awaji Hospital, Hyogo
    Kansenshogaku Zasshi 64:504-9. 1990
    ..It would be of considerable interest from an epidemiological viewpoint to study the vector of these spotted fever group rickettsiae...

Research Grants39

  1. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..the medical and veterinary perspectives;for example, they are vectors of Rickettsia rickettsii causing Rocky Mountain spotted fever;Rickettsia sibirica causing North Asian tick typhus;Rickettsia conori causing Boutenneuse fever;..
  2. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    ..available from the CDC, the incidence of tick-borne disease, including anaplasmosis, ehrlichiosis and Rocky Mountain spotted fever, has been steadily increasing (CDC tick diseases website)...
  3. Host Cell JAK-STAT Activation and Pathogenesis of Spotted Fever Rickettsioses
    Sanjeev K Sahni; Fiscal Year: 2012
    ..conorii are Gram-negative, obligate intracellular a-proteobacteria known to cause Rocky Mountain spotted fever (RMSF) and Mediterranean SF in humans...
  4. Coinfection by Rickettsiae in Amblyomma maculatum: Impact on Disease Transmission
    ANDREA SOARES VARELA-STOKES; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rocky Mountain spotted fever became reportable in the United States nearly a century ago and cases are currently at their highest levels...
  5. INTERSPECIFIC COMPETITION BETWEEN RICKETTSIAE IN TICKS
    Abdu F Azad; Fiscal Year: 2013
    ..in the United States including the highly pathogenic Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever (RMSF)...
  6. First Transcriptome to the Tick Olfactory System
    RICHARD MICHAEL ROE; Fiscal Year: 2012
    ..The American dog tick, Dermacentor variabilis, which is the focus of this proposal is the vector of Rocky Mountain spotted fever in the US, and an excellent model for the studies proposed, in part, because of its large size, ease of ..
  7. Culture and Identification of Rickettsia-like Organisms in Maryland
    Douglas E Norris; Fiscal Year: 2010
    ..The best known of the human rickettsial infections is responsible for Rocky Mountain Spotted Fever (RMSF), a disease that has remained severe with a fatality rate of 3-10%, even with modern medical care...
  8. GENETIC ANALYSIS OF RICKETTSIA PROWAZEKII
    David Wood; Fiscal Year: 2010
    ..In addition, two species, R. rickettsii and R. prowazekii, the causative agents of Rocky Mountain spotted fever and epidemic typhus, respectively, are designated as re-emerging pathogens and Category B Select Agents ..
  9. Manipulation of the actin cytoskeleton by spotted fever group Rickettsia
    Matthew D Welch; Fiscal Year: 2011
    ..of the genus Rickettsia are obligate intracellular bacteria that cause serious human illnesses such as Rocky Mountain Spotted Fever. They require the host actin cytoskeleton to facilitate internalization into host cells, and to power ..
  10. Rickettsia ricketti and Rickettsia-like organisms in Maryland
    Douglas Norris; Fiscal Year: 2009
    ..The best known of the human rickettsial infections is Rocky Mountain Spotted Fever (RMSF), a disease that maintains a fatality rate of 3-10%, even with modern medical care...
  11. REPRODUCTION IN TICKS AND MITES
    James Oliver; Fiscal Year: 1993
    ..variabilis is the major vector of Rocky Mountain Spotted Fever; A...
  12. Development of Paratransgenic ticks for Disease Control
    Ulrike Munderloh; Fiscal Year: 2001
    ..Some are due to the resurgence of previously known illnesses, like Rocky Mountain spotted fever, but others are due to new, emerging pathogens...
  13. RICKETTSIA RICKETTSII IN HUMAN ENDOTHELIAL CELLS
    David Silverman; Fiscal Year: 2002
    ..The investigators are interested in the interaction of R. rickettsii (Rocky Mountain spotted fever) with the endothelial cell, the target cell in human infection, and the mechanism(s) of cell injury ..
  14. Comparative rickettsial protein profiles during tick infection
    KEVIN MACALUSO; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Rickettsia rickettsii is the causative agent of Rocky Mountain spotted fever (RMSF), one of the most severe infectious diseases in the United States...
  15. ACTIN BASED MOTILITY BY RICKETTSIA RICKETTSII
    ROBERT HEINZEN; Fiscal Year: 2002
    ..Spotted fever group (SFG) rickettsiae are the etiologic agents of serious human diseases including Rocky Mountain spotted fever, caused by Rickettsia rickettsii...
  16. TICK-BORNE DISEASE PANEL TEST
    Andrew Levin; Fiscal Year: 2000
    ..agents of Lyme disease, Human Granulocytic Ehrlichiosis, Human Monocytic Ehrlichiosis, Babesiosis, and Rocky Mountain Spotted Fever. Early and accurate diagnosis of these emerging tick-borne diseases is critical to successful therapy, ..
  17. TRANSPORT OF S-ADENOSYLMETHIONINE IN RICKETTSIA
    David Wood; Fiscal Year: 2002
    ..Epidemic and endemic typhus and rocky mountain spotted fever caused by R. prowazekii, R. typhi and R...
  18. RICKETTSIA-INDUCED TRANSCRIPTIONAL ACTIVATION
    SANJEEV SAHNI; Fiscal Year: 2002
    b>Rocky Mountain spotted fever, the most prevalent and important of the rickettsioses in the United States, is an acute tick-borne febrile illness caused by Rickettsia rickettsii...
  19. Role of the endothelium in the T cell-mediated anti-rickettsial immune response
    Gustavo Valbuena; Fiscal Year: 2009
    ..bacteria include agents of potential use for bioterrorism such as Rickettsia rickettsii (the cause of Rocky Mountain spotted fever) and R. prowazekii (the cause of epidemic typhus)...
  20. Sequence of Rickettsia Rickettsii Genome
    Anup Madan; Fiscal Year: 2001
    ..It is the etiologic agent of Rocky Mountain spotted fever, the most severe of the human rickettsioses...
  21. Molecular dynamics of rickettsial infection in ticks
    KEVIN MACALUSO; Fiscal Year: 2006
    b>Rocky Mountain spotted fever is the most frequently reported rickettsial disease in the United States...
  22. T-DNA INTEGRATION DURING CROWN GALL TUMORIGENESIS
    LLOYD REAM; Fiscal Year: 1991
    ..Agrobacterium and rickettsiae (bacteria which cause trench fever, Q fever, and Rocky Mountain spotted fever in humans) share lifestyle similarities (close association with eukaryotic host cells and plasmids ..
  23. EVALUATION OF LATEX TEST IN ROCKY MOUNTAIN SPOTTED FEVER
    KARIM HECHEMY; Fiscal Year: 1980
    ..evaluation of the newly developed, simple, sensitive, specific, rapid latex test for the detection of Rocky Mountain spotted fever in collaboration with other state health departments where RMSF is endemic...
  24. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  25. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  26. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
  27. RICKETTSIA-INDUCED TRANSCRIPTIONAL ACTIVATION
    SANJEEV SAHNI; Fiscal Year: 2007
    Rickettsia rickettsii, an obligate intracellular bacterium and etiologic agent of Rocky Mountain spotted fever, infects and proliferates predominantly within vascular endothelial cells, which respond by activating a series of distinct ..
  28. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ..Among them are Rocky Mountain spotted fever and epidemic typhus caused respectively by R. rickettsii and R. prowazekii...
  29. Murine Typhus: Vector Biology & Transmission
    Abdu Azad; Fiscal Year: 2007
    ..typhi and ELB upon challenge with[unreadable] the heterologous rickettsiae and involvement of 120 kDa in the protection.[unreadable] [unreadable]..
  30. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
    ..The underlying hypothesis tested is whether recombinant strains with altered genes maintain their immunogenicity within mammals and provide cross protection to subsequent challenge with virulent strains. ..
  31. Modulation of Host Cell Apoptosis By Pathogenic Rickettsiae
    SANJEEV SAHNI; Fiscal Year: 2008
    ..b>Rocky Mountain spotted fever and epidemic typhus, caused respectively by R. rickettsii and R...
  32. Proximal determinants of risk for tularemia outbreaks
    Sam Telford; Fiscal Year: 2004
    ..tularensis in the environment; and, ultimately, a better understanding of F. tularensis-host interactions. ..
  33. HOST IMMUNOSUPPRESSIVE PROTEINS OF TICK SALIVARY GLAND
    Stephen Wikel; Fiscal Year: 2003
    ..And 4) purify and clone additional immunomodulatory proteins from two size ranges previously identified using preparative SDS-PAGE fractionation, as well as determine their immunomodulatory activities and utility as vaccine immunogens. ..
  34. Perpetuation of Francisella tularensis
    Sam R Telford; Fiscal Year: 2010
    ..Taken together, these observations will provide a basis for understanding how the agent of tularemia is perpetuated on Martha's Vineyard, and why pneumonic human disease is prevalent there. ..
  35. Tick polarized T-cell responses and Borrelia infection
    Stephen K Wikel; Fiscal Year: 2010
    ..The third aim is to immunize with the recombinant forms of the reactive salivary gland molecules and determine whether tick induced cytokine polarization and B. burgdorferi transmission are blocked. ..