dengue

Summary

Summary: An acute infectious, eruptive, febrile disease caused by four antigenically related but distinct serotypes of the DENGUE VIRUS. It is transmitted by the bite of infected Aedes mosquitoes, especially A. aegypti. Classical dengue (dengue fever) is self-limiting and characterized by fever, myalgia, headache, and rash. DENGUE HEMORRHAGIC FEVER is a more virulent form of dengue virus infection and a separate clinical entity. (From Dorland, 28th ed)

Top Publications

  1. pmc The global distribution and burden of dengue
    Samir Bhatt
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 496:504-7. 2013
  2. doi Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial
    Arunee Sabchareon
    Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 380:1559-67. 2012
  3. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
  4. ncbi Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
    John S Mackenzie
    Australian Biosecurity Cooperative Research Centre, Curtin University of Technology, Perth, Western Australia
    Nat Med 10:S98-109. 2004
  5. doi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
  6. doi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
  7. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
  8. pmc Cross-reacting antibodies enhance dengue virus infection in humans
    Wanwisa Dejnirattisai
    Department of Medicine, Imperial College London, London W12 0NN, UK
    Science 328:745-8. 2010
  9. pmc Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission
    Louis Lambrechts
    Department of Virology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e646. 2010
  10. doi The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
    T Walker
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 476:450-3. 2011

Detail Information

Publications288 found, 100 shown here

  1. pmc The global distribution and burden of dengue
    Samir Bhatt
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 496:504-7. 2013
    b>Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For some patients, dengue is a life-threatening illness...
  2. doi Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial
    Arunee Sabchareon
    Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 380:1559-67. 2012
    Roughly half the world's population live in dengue-endemic countries, but no vaccine is licensed. We investigated the efficacy of a recombinant, live, attenuated tetravalent dengue vaccine.
  3. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
    The four dengue viruses are transmitted in tropical countries that circle the globe. All can cause syndromes that are self-limited or severe...
  4. ncbi Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
    John S Mackenzie
    Australian Biosecurity Cooperative Research Centre, Curtin University of Technology, Perth, Western Australia
    Nat Med 10:S98-109. 2004
    ..Here, we describe three of them: the resurgence of dengue in tropical and subtropical areas of the world, and the spread and establishment of Japanese encephalitis and West ..
  5. doi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
    b>Dengue is a spectrum of disease caused by four serotypes of the most prevalent arthropod-borne virus affecting humans today, and its incidence has increased dramatically in the past 50 years...
  6. doi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
    ..Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster, successfully invaded two natural A...
  7. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
    ..When introduced to nonnative mosquito hosts, Wolbachia induce resistance to a number of human pathogens, including dengue virus (DENV), Plasmodium, and filarial nematodes, but the molecular mechanism involved is unclear...
  8. pmc Cross-reacting antibodies enhance dengue virus infection in humans
    Wanwisa Dejnirattisai
    Department of Medicine, Imperial College London, London W12 0NN, UK
    Science 328:745-8. 2010
    b>Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common...
  9. pmc Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission
    Louis Lambrechts
    Department of Virology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e646. 2010
    ..of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae...
  10. doi The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
    T Walker
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 476:450-3. 2011
    b>Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries...
  11. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    b>Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation...
  12. doi From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine
    Bruno Guy
    Research and Development, Sanofi Pasteur, 69280 Marcy l Etoile, France
    Vaccine 29:7229-41. 2011
    b>Dengue vaccine development has reached a major milestone with the initiation, in 2010, of the first phase III clinical trial to investigate the Sanofi Pasteur CYD tetravalent dengue vaccine (TDV)...
  13. pmc The role of human movement in the transmission of vector-borne pathogens
    Steven T Stoddard
    Entomology, University of California, Davis, California, United States of America
    PLoS Negl Trop Dis 3:e481. 2009
    ..Here we develop a conceptual model to evaluate the importance of variation in exposure due to individual human movements for pathogen transmission, focusing on mosquito-borne dengue virus.
  14. pmc The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
    Martina Beltramello
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    Cell Host Microbe 8:271-83. 2010
    Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR)...
  15. doi Immune response to dengue virus and prospects for a vaccine
    Brian R Murphy
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:587-619. 2011
    b>Dengue virus (DENV) is a mosquito-borne member of the Flavivirus genus and includes four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), each of which is capable of causing dengue fever and dengue hemorrhagic fever/dengue shock syndrome...
  16. doi Next generation dengue vaccines: a review of candidates in preclinical development
    Julia Schmitz
    Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland
    Vaccine 29:7276-84. 2011
    b>Dengue represents a major public health problem of growing global importance. In the absence of specific dengue therapeutics, strategies for disease control have increasingly focused on the development of dengue vaccines...
  17. ncbi Dengue virus-mosquito interactions
    Scott B Halstead
    Pediatric Dengue Vaccine Initiative, Bethesda, MD 20852, USA
    Annu Rev Entomol 53:273-91. 2008
    ..now than at any time in the past, placing billions of humans at risk of infection with one or more of the four dengue viruses...
  18. pmc Genetic elimination of dengue vector mosquitoes
    Megan R Wise de Valdez
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Proc Natl Acad Sci U S A 108:4772-5. 2011
    ..gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression...
  19. pmc Dengue--quo tu et quo vadis?
    Rubing Chen
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Viruses 3:1562-608. 2011
    b>Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population...
  20. pmc Dengue-1 virus clade replacement in Thailand associated with enhanced mosquito transmission
    Louis Lambrechts
    Department of Virology, Institut Pasteur, Paris, France
    J Virol 86:1853-61. 2012
    b>Dengue viruses (DENV) are characterized by extensive genetic diversity and can be organized in multiple, genetically distinct lineages that arise and die out on a regular basis in regions where dengue is endemic...
  21. doi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009
    ..of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions...
  22. ncbi Critical review of the vector status of Aedes albopictus
    N G Gratz
    Med Vet Entomol 18:215-27. 2004
    ..albopictus is a competent vector for at least 22 arboviruses), notably dengue (all four serotypes) more commonly transmitted by Aedes (Stegomyia) aegypti (L.)...
  23. ncbi Neutralization and antibody-dependent enhancement of dengue viruses
    Scott B Halstead
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Adv Virus Res 60:421-67. 2003
  24. pmc Economic impact of dengue illness in the Americas
    Donald S Shepard
    Brandeis University, Waltham, MA 02454 9110, USA
    Am J Trop Med Hyg 84:200-7. 2011
    The growing burden of dengue in endemic countries and outbreaks in previously unaffected countries stress the need to assess the economic impact of this disease...
  25. ncbi Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization
    Kala Jessie
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Infect Dis 189:1411-8. 2004
    b>Dengue viral antigens have been demonstrated in several types of naturally infected human tissues, but little is known of whether these same tissues have detectable viral RNA...
  26. pmc Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania
    Julian T Hertz
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Trop Med Hyg 86:171-7. 2012
    ..Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result...
  27. pmc Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions
    Ruklanthi de Alwis
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:7439-44. 2012
    b>Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has developed into a major health and economic burden in over 50 countries...
  28. pmc The human antibody response to dengue virus infection
    Wahala M P B Wahala
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Viruses 3:2374-95. 2011
    b>Dengue viruses (DENV) are the causative agents of dengue fever (DF) and dengue hemorrhagic fever (DHF). Here we review the current state of knowledge about the human antibody response to dengue and identify important knowledge gaps...
  29. pmc Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Negl Trop Dis 5:e1385. 2011
    The mosquito Aedes aegypti is the primary vector of dengue virus (DENV) infection in humans, and DENV is the most important arbovirus across most of the subtropics and tropics worldwide...
  30. pmc Kinetics of viremia and NS1 antigenemia are shaped by immune status and virus serotype in adults with dengue
    Vianney Tricou
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Ho Chi Minh City, Viet Nam
    PLoS Negl Trop Dis 5:e1309. 2011
    b>Dengue is a major public health problem in tropical and subtropical countries...
  31. pmc Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
    Marcus S C Blagrove
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Proc Natl Acad Sci U S A 109:255-60. 2012
    ..cytoplasmic incompatibility and provide new strategies for controlling mosquito-borne tropical diseases, such as dengue. The overreplicating wMelPop strain was recently shown to strongly inhibit the replication of dengue virus when ..
  32. doi Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
    Alan L Rothman
    Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island 02903, USA
    Nat Rev Immunol 11:532-43. 2011
    b>Dengue is a mosquito-borne viral disease of expanding geographical range and incidence...
  33. pmc Refining the global spatial limits of dengue virus transmission by evidence-based consensus
    Oliver J Brady
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Negl Trop Dis 6:e1760. 2012
    b>Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain...
  34. pmc Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections
    Sophie Alcon
    Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Clin Microbiol 40:376-81. 2002
    ..in vivo, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) to detect the protein in the sera of dengue virus-infected patients...
  35. pmc Usefulness and applicability of the revised dengue case classification by disease: multi-centre study in 18 countries
    Judit Barniol
    Section Clinical Tropical Medicine, Department for Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    BMC Infect Dis 11:106. 2011
    In view of the long term discussion on the appropriateness of the dengue classification into dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), the World Health Organization (WHO) has outlined in its new ..
  36. pmc The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
    ..Given the large overlap in tissue distribution and intracellular localization between Wolbachia and dengue virus in mosquitoes, we conducted experiments to characterize their interactions...
  37. pmc The Aedes aegypti toll pathway controls dengue virus infection
    Zhiyong Xi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 4:e1000098. 2008
    Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans...
  38. pmc Revealing the microscale spatial signature of dengue transmission and immunity in an urban population
    Henrik Salje
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:9535-8. 2012
    ..Here, we use the location of dengue patients' homes in Bangkok with the serotype of the infecting pathogen to investigate the spatiotemporal ..
  39. pmc Dengue virus targets the adaptor protein MITA to subvert host innate immunity
    Chia Yi Yu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    PLoS Pathog 8:e1002780. 2012
    b>Dengue is one of the most important arboviral diseases caused by infection of four serotypes of dengue virus (DEN)...
  40. pmc Animal models of dengue virus infection
    Simona Zompi
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 1 Barker Hall, Berkeley, CA 94720, USA
    Viruses 4:62-82. 2012
    The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species...
  41. pmc Dengue outbreak in Key West, Florida, USA, 2009
    Elizabeth G Radke
    Florida Department of Health, Tallahassee, Florida, USA
    Emerg Infect Dis 18:135-7. 2012
    After 3 dengue cases were acquired in Key West, Florida, we conducted a serosurvey to determine the scope of the outbreak...
  42. pmc Forecast of dengue incidence using temperature and rainfall
    Yien Ling Hii
    Umeå Centre for Global Health Research, Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    PLoS Negl Trop Dis 6:e1908. 2012
    ..early warning system to predict impending epidemics enhances the effectiveness of preventive measures against dengue fever...
  43. pmc Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic
    Camila Malta Romano
    Departamento de Moléstias Infecciosas e Parasitárias LIMHC, Instituto de Medicina Tropical de São Paulo e Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 5:e11811. 2010
    b>Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State...
  44. pmc Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance
    Ashley L St John
    Duke National University of Singapore, Singapore 169857
    Proc Natl Acad Sci U S A 108:9190-5. 2011
    ..We now report that rodent, monkey, and human MCs are able to detect dengue virus (DENV), a lymphotropic, enveloped, single-stranded, positive-sense RNA virus that results in MC activation ..
  45. pmc Evaluation of the traditional and revised WHO classifications of Dengue disease severity
    Federico Narvaez
    Infectious Diseases Unit, Hospital Infantil Manuel de Jesus Rivera, Managua, Nicaragua
    PLoS Negl Trop Dis 5:e1397. 2011
    b>Dengue is a major public health problem worldwide and continues to increase in incidence...
  46. ncbi Potential effect of population and climate changes on global distribution of dengue fever: an empirical model
    Simon Hales
    Department of Public Health, Wellington School of Medicine and Health Sciences, PO Box 7343, Mein Street, Wellington, New Zealand
    Lancet 360:830-4. 2002
    ..Our aim was to investigate the potential effects of global climate change on human health, and in particular, on the transmission of vector-borne diseases...
  47. pmc Economic and disease burden of dengue in Southeast Asia
    Donald S Shepard
    Schneider Institutes for Health Policy, Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts, USA
    PLoS Negl Trop Dis 7:e2055. 2013
    b>Dengue poses a substantial economic and disease burden in Southeast Asia (SEA). Quantifying this burden is critical to set policy priorities and disease-control strategies.
  48. ncbi Prospects for a dengue virus vaccine
    Stephen S Whitehead
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 5:518-28. 2007
    The number of cases of severe dengue disease continues to grow in endemic areas of southeast Asia, Central and South America, and other subtropical regions...
  49. ncbi Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines
    Celia C Carlos
    Department of Pediatrics, and Research and Biotechnology Division, St Luke s Medical Center, Quezon City, The Philippines
    Am J Trop Med Hyg 73:435-40. 2005
    To demonstrate the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St...
  50. pmc Genetic mapping of specific interactions between Aedes aegypti mosquitoes and dengue viruses
    Thanyalak Fansiri
    Institut Pasteur, Centre National de la Recherche Scientifique, Unite de Recherche Associee 3012, Paris, France
    PLoS Genet 9:e1003621. 2013
    ..In this study, we aimed to determine whether G×G interactions observed between dengue viruses and their Aedes aegypti vectors in nature can be mapped to discrete loci in the mosquito genome and to ..
  51. pmc The incubation periods of Dengue viruses
    Miranda Chan
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    PLoS ONE 7:e50972. 2012
    b>Dengue viruses are major contributors to illness and death globally. Here we analyze the extrinsic and intrinsic incubation periods (EIP and IIP), in the mosquito and human, respectively...
  52. pmc Wolbachia uses a host microRNA to regulate transcripts of a methyltransferase, contributing to dengue virus inhibition in Aedes aegypti
    Guangmei Zhang
    Australian Infectious Disease Research Centre, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
    Proc Natl Acad Sci U S A 110:10276-81. 2013
    ..showed that Wolbachia uses host microRNAs to manipulate host gene expression for its efficient maintenance in the dengue mosquito vector, Aedes aegypti...
  53. pmc Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
    Minh Nguyen Nguyet
    Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Vietnam
    Proc Natl Acad Sci U S A 110:9072-7. 2013
    b>Dengue is the most prevalent arboviral disease of humans...
  54. pmc High-content assay to identify inhibitors of dengue virus infection
    David Shum
    HTS Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Assay Drug Dev Technol 8:553-70. 2010
    b>Dengue virus (DENV) infections are vectored by mosquitoes and constitute one of the most prevalent infectious diseases in many parts of the world, affecting millions of people annually...
  55. ncbi The Innovative Vector Control Consortium: improved control of mosquito-borne diseases
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 22:308-12. 2006
    ..this new initiative to enable industry and academia to change the vector control paradigm for malaria and dengue and to ensure that vector control, alongside drugs, case management and vaccines, can be better used to reduce ..
  56. pmc The relative importance of innate immune priming in Wolbachia-mediated dengue interference
    Edwige Rancès
    School of Biological Sciences, Monash University, Clayton, Australia
    PLoS Pathog 8:e1002548. 2012
    ..wMelPop-CLA, both originally from Drosophila melanogaster, have been stably introduced into the mosquito vector of dengue fever, Aedes aegypti...
  57. doi Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
    Singapore experienced its worst dengue outbreak in 30 years in 2004, with 9459 notified cases, of which 83% were hospitalized.
  58. pmc Dengue infection increases the locomotor activity of Aedes aegypti females
    Tamara N Lima-Camara
    Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 6:e17690. 2011
    Aedes aegypti is the main vector of the virus causing Dengue fever, a disease that has increased dramatically in importance in recent decades, affecting many tropical and sub-tropical areas of the globe...
  59. doi Critical issues in dengue vaccine development
    Stephen J Thomas
    Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Curr Opin Infect Dis 24:442-50. 2011
    b>Dengue is currently an expanding global health problem. Development of an effective tetravalent dengue vaccine is considered a high public health priority...
  60. ncbi Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua
    Samantha Nadia Hammond
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Am J Trop Med Hyg 73:1063-70. 2005
    To investigate age-related differences in dengue severity, 114 infants, 1,211 children, and 346 adults with laboratory-confirmed dengue virus (DEN) infections presenting to three hospitals in major urban centers in Nicaragua were ..
  61. ncbi Dispersal of the dengue vector Aedes aegypti within and between rural communities
    Laura C Harrington
    Department of Entomology, Cornell University, Ithaca, New York 14850, USA
    Am J Trop Med Hyg 72:209-20. 2005
    ..Results demonstrate that adult Ae. aegypti disperse relatively short distances, suggesting that people rather than mosquitoes are the primary mode of dengue virus dissemination within and among communities.
  62. pmc Insecticide resistance in the dengue vector Aedes aegypti from Martinique: distribution, mechanisms and relations with environmental factors
    Sebastien Marcombe
    Unité mixte de recherche MIVEGEC UM1 CNRS 5290 IRD 224, Institut de recherche pour le developpement IRD, Montpellier, France
    PLoS ONE 7:e30989. 2012
    b>Dengue is an important mosquito borne viral disease in Martinique Island (French West Indies). The viruses responsible for dengue are transmitted by Aedes aegypti, an indoor day-biting mosquito...
  63. pmc Eco-bio-social determinants of dengue vector breeding: a multicountry study in urban and periurban Asia
    Natarajan Arunachalam
    Centre for Research in Medical Entomology, Indian Council of Medical Research, Madurai, TN, India
    Bull World Health Organ 88:173-84. 2010
    To study dengue vector breeding patterns under a variety of conditions in public and private spaces; to explore the ecological, biological and social (eco-bio-social) factors involved in vector breeding and viral transmission, and to ..
  64. pmc Spatial evaluation and modeling of Dengue seroprevalence and vector density in Rio de Janeiro, Brazil
    Nildimar Alves Honorio
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
    PLoS Negl Trop Dis 3:e545. 2009
    Rio de Janeiro, Brazil, experienced a severe dengue fever epidemic in 2008. This was the worst epidemic ever, characterized by a sharp increase in case-fatality rate, mainly among younger individuals...
  65. doi The pathogenesis of dengue
    Jamie Whitehorn
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Vaccine 29:7221-8. 2011
    b>Dengue is an important cause of childhood and adult morbidity in Asian and Latin American countries and its geographic footprint is growing...
  66. pmc Spatial and temporal clustering of dengue virus transmission in Thai villages
    Mammen P Mammen
    Department of Virology, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    PLoS Med 5:e205. 2008
    Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and environment...
  67. pmc Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus
    Gilberto A Santiago
    Centers for Disease Control and Prevention, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico, USA
    PLoS Negl Trop Dis 7:e2311. 2013
    b>Dengue is an acute illness caused by the positive-strand RNA dengue virus (DENV). There are four genetically distinct DENVs (DENV-1-4) that cause disease in tropical and subtropical countries...
  68. doi Spatiotemporal patterns of Aedes aegypti populations in Cairns, Australia: assessing drivers of dengue transmission
    Jennifer Duncombe
    Infectious Disease Epidemiology Unit, The University of Queensland, Brisbane, Australia
    Trop Med Int Health 18:839-49. 2013
    To identify the meteorological drivers of dengue vector density and determine high- and low-risk transmission zones for dengue prevention and control in Cairns, Australia.
  69. pmc Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009
    Hoang Quoc Cuong
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Unit, Hanoi, Vietnam
    PLoS Negl Trop Dis 5:e1322. 2011
    An estimated 2.4 billion people live in areas at risk of dengue transmission, therefore the factors determining the establishment of endemic dengue in areas where transmission suitability is marginal is of considerable importance...
  70. doi Potential distribution of dengue fever under scenarios of climate change and economic development
    Christofer Aström
    Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Ecohealth 9:448-54. 2012
    b>Dengue fever is the most important viral vector-borne disease with ~50 million cases per year globally...
  71. pmc Dengue virus capsid protein usurps lipid droplets for viral particle formation
    Marcelo M Samsa
    Fundación Instituto Leloir CONICET, Buenos Aires, Argentina
    PLoS Pathog 5:e1000632. 2009
    b>Dengue virus is responsible for the highest rates of disease and mortality among the members of the Flavivirus genus. Dengue epidemics are still occurring around the world, indicating an urgent need of prophylactic vaccines and antivirals...
  72. ncbi Neurological manifestations of dengue infection
    T Solomon
    Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    Lancet 355:1053-9. 2000
    Severe forms of dengue, the most important arboviral infection of man, are associated with haemorrhagic disease and a generalised vascular leak syndrome. The importance of dengue as a cause of neurological disease is uncertain.
  73. doi Dengue vaccines: progress and challenges
    Beth Ann G Coller
    Vaccines Research, WP17 2131, Merck and Company, 770 Sumneytown Pike, P O Box 4, West Point, PA 19486, United States
    Curr Opin Immunol 23:391-8. 2011
    With several dengue vaccine candidates progressing through clinical trials, several options for controlling this disease appear feasible. This would represent a major achievement and reflect decades of research and development activities...
  74. pmc Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis
    Karen Clyde
    Division of Infectious Diseases, School of Public Health, 140 Warren Hall, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    J Virol 80:11418-31. 2006
  75. ncbi Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand
    Timothy P Endy
    Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Epidemiol 156:40-51. 2002
    b>Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Knowledge about the epidemiology and host determinants of inapparent and severe dengue virus infections is limited...
  76. pmc High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections
    Khoa T D Thai
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Virol 86:835-43. 2012
    Little is known about the rate at which genetic variation is generated within intrahost populations of dengue virus (DENV) and what implications this diversity has for dengue pathogenesis, disease severity, and host immunity...
  77. pmc Liver involvement associated with dengue infection in adults in Vietnam
    Dinh The Trung
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Am J Trop Med Hyg 83:774-80. 2010
    Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children...
  78. pmc Validation of an internally controlled one-step real-time multiplex RT-PCR assay for the detection and quantitation of dengue virus RNA in plasma
    Kien Duong Thi Hue
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Viet Nam
    J Virol Methods 177:168-73. 2011
    b>Dengue is mosquito-borne virus infection that annually causes ~50 million clinically apparent cases worldwide...
  79. pmc Dengue--how best to classify it
    Anon Srikiatkhachorn
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Infect Dis 53:563-7. 2011
    b>Dengue has emerged as a major public health problem worldwide. Dengue virus infection causes a wide range of clinical manifestations...
  80. pmc Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status
    Huynh T L Duyen
    Oxford University Clinical Research Unit, Churchill Hospital, Oxford, UK
    J Infect Dis 203:1292-300. 2011
    ..of plasma viremia and nonstructural protein 1 (sNS1) levels in sequential samples from 167 children with acute dengue, enrolled early in a community study in Vietnam. All children recovered fully, and only 5 required hospitalization...
  81. pmc Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking
    Hilde M van der Schaar
    Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Ant Deusinglaan 1, 9700 RB Groningen, The Netherlands
    J Virol 81:12019-28. 2007
    In this study, we investigated the cell entry characteristics of dengue virus (DENV) type 2 strain S1 on mosquito, BHK-15, and BS-C-1 cells...
  82. pmc Climate-based models for understanding and forecasting dengue epidemics
    Elodie Descloux
    UMR190, Emergence of Viral Pathologies, Institute of Research for the Development, Aix Marseille University, Marseille, France
    PLoS Negl Trop Dis 6:e1470. 2012
    b>Dengue dynamics are driven by complex interactions between human-hosts, mosquito-vectors and viruses that are influenced by environmental and climatic factors...
  83. pmc Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota, innate immune system and dengue virus influences vector competence
    Jose Luis Ramirez
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 6:e1561. 2012
    b>Dengue virus is one of the most important arboviral pathogens and the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome...
  84. doi Geographic expansion of dengue: the impact of international travel
    Annelies Wilder-Smith
    Department of Medicine, Travelers Screening and Vaccination Clinic, National University Hospital of Singapore, National University of Singapore, 5, Lower Kent Ridge, Singapore 119074
    Med Clin North Am 92:1377-90, x. 2008
    b>Dengue has emerged as an international public health problem...
  85. doi Reducing costs and operational constraints of dengue vector control by targeting productive breeding places: a multi-country non-inferiority cluster randomized trial
    W Tun-Lin
    Department of Medical Research, Yangon, Myanmar
    Trop Med Int Health 14:1143-53. 2009
    ....
  86. pmc Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity
    Fernando A Bozza
    Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    BMC Infect Dis 8:86. 2008
    b>Dengue virus pathogenesis is not yet fully understood and the identification of patients at high risk for developing severe disease forms is still a great challenge in dengue patient care...
  87. pmc Dengue incidence in urban and rural Cambodia: results from population-based active fever surveillance, 2006-2008
    Sirenda Vong
    Institut Pasteur Cambodia, Phnom Penh, Cambodia
    PLoS Negl Trop Dis 4:e903. 2010
    b>Dengue vaccines are now in late-stage development, and evaluation and robust estimates of dengue disease burden are needed to facilitate further development and introduction...
  88. pmc In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection
    Ruklanthi de Alwis
    Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    PLoS Negl Trop Dis 5:e1188. 2011
    Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection...
  89. pmc An in-depth analysis of original antigenic sin in dengue virus infection
    Claire M Midgley
    Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom
    J Virol 85:410-21. 2011
    The evolution of dengue viruses has resulted in four antigenically similar yet distinct serotypes. Infection with one serotype likely elicits lifelong immunity to that serotype, but generally not against the other three...
  90. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    b>Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation ..
  91. pmc Dengue virus pathogenesis: an integrated view
    Byron E E Martina
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Clin Microbiol Rev 22:564-81. 2009
    Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans...
  92. pmc Dengue: a continuing global threat
    Maria G Guzman
    Instituto de Medicina Tropical, Pedro Kouri, PO Box 601, Marianao 13, Ciucad de la Habana, Cuba
    Nat Rev Microbiol 8:S7-16. 2010
    b>Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases...
  93. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
    b>Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences.
  94. pmc House-to-house human movement drives dengue virus transmission
    Steven T Stoddard
    Department of Entomology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:994-9. 2013
    b>Dengue is a mosquito-borne disease of growing global health importance. Prevention efforts focus on mosquito control, with limited success...
  95. ncbi First two autochthonous dengue virus infections in metropolitan France, September 2010
    G La Ruche
    French Institute for Public Health Surveillance Institut de Veille Sanitaire, InVS, Saint Maurice, France
    Euro Surveill 15:19676. 2010
    In September 2010, two cases of autochthonous dengue fever were diagnosed in metropolitan France for the first time...
  96. pmc Phylogeography of dengue virus serotype 4, Brazil, 2010-2011
    Marcio Roberto Teixeira Nunes
    Departamento de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, Brazil
    Emerg Infect Dis 18:1858-64. 2012
    b>Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982...
  97. doi Ten years of dengue drug discovery: progress and prospects
    Siew Pheng Lim
    Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05 01 Chromos, Singapore 138670, Singapore
    Antiviral Res 100:500-19. 2013
    ..One of NITD's missions is to develop antivirals for dengue virus (DENV), the most prevalent mosquito-borne viral pathogen...
  98. pmc Spatial patterns and socioecological drivers of dengue fever transmission in Queensland, Australia
    Wenbiao Hu
    School of Population Health, The University of Queensland, Brisbane, Queensland, Australia
    Environ Health Perspect 120:260-6. 2012
    Understanding how socioecological factors affect the transmission of dengue fever (DF) may help to develop an early warning system of DF.
  99. pmc Immature dengue virus: a veiled pathogen?
    Izabela A Rodenhuis-Zybert
    Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS Pathog 6:e1000718. 2010
    Cells infected with dengue virus release a high proportion of immature prM-containing virions. In accordance, substantial levels of prM antibodies are found in sera of infected humans...
  100. pmc Population dynamics of Aedes aegypti and dengue as influenced by weather and human behavior in San Juan, Puerto Rico
    Roberto Barrera
    Entomology and Ecology Activity, Dengue Branch, Centers for Disease Control and Prevention, Calle Cañada, San Juan, Puerto Rico
    PLoS Negl Trop Dis 5:e1378. 2011
    ..dynamics in Puerto Rico suggested that rainfall was a significant driver of immature mosquito populations and dengue incidence, but mostly in the drier areas of the island. We conducted a longitudinal study of Ae...
  101. pmc The epidemiology of dengue in the americas over the last three decades: a worrisome reality
    José Luis San Martín
    Dengue Regional Program, Pan American Health Organization PAHO, Panama, Republic of Panama
    Am J Trop Med Hyg 82:128-35. 2010
    We have reported the epidemic patterns of dengue disease in the Region of the Americas from 1980 through 2007...

Research Grants76

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..tuberculosis, variola major related pox viruses, Dengue, and West Nile)...
  2. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..For example, dengue endemic regions have rapidly expanded throughout the world, especially in South America...
  3. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are diseases caused by 4 serotypes of dengue virus (DV)...
  4. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..including that of Kyasanur Forest Disease (KFD), Leptospirosis, Rickettsial disease such as Scrub Typhus, Dengue and Lyme disease in the Western Ghat region of India...
  5. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    ..list of Class A, B, or C emerging human pathogens such as Yellow fever virus (YFV), West Nile virus (WNV) and Dengue (DEN1-4) viruses that cause serious illnesses with considerable morbidity and mortality...
  6. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..These studies will include the yellow and dengue fever virus vector Aedes aegypti, as well as the malaria vector Anopheles gambiae...
  7. Development of a Recombinant Tetravalent Dengue Vaccine Based on a Subunit Envelo
    Lynda G Tussey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue disease poses a significant threat to over 2.5 billion people worldwide and currently, no licensed vaccine is available...
  8. Fatty Acid Synthase Inhibitors As Broad Spectrum Anti-Flaviviral Therapeutics
    Glenn Randall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus (DENV) is the most clinically important arbovirus and a Category A bioterrorism agent...
  9. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE D RYMAN; Fiscal Year: 2010
    ..In adults, the infection resembles dengue fever, with acute febrile illness associated with excruciating muscle and joint pain...
  10. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    Yearly, millions of people die, or are seriously debilitated, from malaria, dengue fever, yellow fever and several forms of viral encephalitis. Hematophageous mosquitoes transmit the causative agents of these diseases [1, 2]...
  11. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..g. Ebola virus, Lassa fever virus, Dengue virus, etc.)...
  12. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..target RNA viruses, focusing on pathogens with abnormally high global burdens of disease: hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and human ..
  13. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..dendritic cell receptor for human immunodeficiency virus (HIV-1 and HIV-2), simian immunodeficiency virus (SIV), dengue virus, Marburg virus, hepatitis C, Ebola, and cytomegalovirus...
  14. Alternative regulation of ISGs in WNV-infected cells
    Margo A Brinton; Fiscal Year: 2013
    ..flaviviruses, including West Nile virus (WNV), Japanese encephalitis virus, tick- borne encephalitis virus and dengue virus, are significant human pathogens...
  15. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..Relevance: Many mosquito-borne disease agents, including malaria parasites, dengue virus, and West Nile virus, must develop in mosquitoes for extended periods before being transmitted to humans...
  16. Key determinants of dengue virus neutralization by naturally occurring human mAbs
    Scott A Smith; Fiscal Year: 2013
    ..of the science in the current application, is focused on generation and study of human monoclonal antibodies to dengue viruses...
  17. Mosquito Saliva in Dengue Virus Pathogenesis
    REBECCA R RICO-HESSE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mosquito Saliva in Dengue Virus Pathogenesis. Dengue virus is a single-stranded RNA Flavivirus that causes dengue fever (DF), the most prevalent arthropod-borne viral illness in humans...
  18. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    ..influenza (currently in clinical trial) and flaviviruses such as West Nile virus, Japanese encephalitis virus, and Dengue virus by VaxInnate...
  19. A semi field trial test on efficacy of transgenic antimalarial biocontrol fungi
    Raymond J St Leger; Fiscal Year: 2013
    ..population lives in areas where mosquito-borne diseases including malaria, filariasis, viral encephalitides, dengue and yellow fever are endemic...
  20. MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSION
    Abdu F Azad; Fiscal Year: 2013
    ..Due to its resemblance to diseases like typhoid- or dengue fever it is often misdiagnosed and under reported...
  21. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Four serotypes of dengue virus (DENV-1-4) that circulate globally, causing more human illness than any other arthropod-borne virus...
  22. The Mechanisms of IFITM-Mediated Restriction
    I Chueh Huang; Fiscal Year: 2013
    ..IFITM) proteins critical to the interferon-mediated control of several pathogenic viruses, including IAV, dengue virus and West Nile virus...
  23. The role of the host Ca/Mn pump in emergence of novel viral RNA recombinants
    Peter Nagy; Fiscal Year: 2010
    ..of the similarity of TBSV replicase proteins to proteins of important pathogens, such as Hepatitis C virus (HCV), dengue virus, West Nile virus and other Flaviviruses and Pestiviruses...
  24. Development of a Recombinant Subunit Vaccine for CCHF
    David E Clements; Fiscal Year: 2013
    ..Candidate vaccines against dengue and West Nile virus have already been produced in this system and both have entered clinical trials...
  25. Rational Development of Candidate Attenuated Flavivirus Vaccines
    Tian Wang; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The flaviviruses contain many pathogens of public health importance, including dengue virus (DENV) and West Nile virus (WNV) for which we have no licensed vaccines...
  26. MOLECULAR MECHANISMS OF ALPHAVIRUS ENTRY AND EXIT
    Margaret Kielian; Fiscal Year: 2013
    ..important human pathogens such as the encephalitic alphaviruses and chikungunya virus, and the flaviviruses dengue, yellow fever, and West Nile virus...
  27. Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using Odorants
    Anandasankar Ray; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aedes aegypti mosquitoes transmit Dengue and Yellow Fever virus, and Culex quinquefasciatus mosquitoes transmit the West Nile virus and filarial parasite Wuchereria bancrofti to hundreds of millions ..
  28. Mechanism of RNA synthesis and 5'-capping by dengue virus NS5 polymerase
    Kyung H Choi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Flaviviruses including dengue, West Nile, yellow fever, and Japanese encephalitis viruses, pose significant threats as emerging diseases and potential bioterror agents...
  29. Novel Tetravalent Vaccines for Dengue Virus
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus infection is an emerging disease and an expanding global health problem...
  30. Control of cap-independent translation by a viral 3'UTR
    WYATT ALLEN MILLER; Fiscal Year: 2013
    ..Although this work focuses on model plant viruses, many growing human viruses such as dengue and hepatitis C viruses use similar mechanisms...
  31. Innate Immune Recognition Enhances Flavivirus Vaccine Efficacy
    Gregg N Milligan; Fiscal Year: 2010
    ..Vaccines are urgently needed for multiple flavivirus diseases, notably dengue and West Nile encephalitis...
  32. Role of innate immunity in responding to an alphavirus-based adjuvant
    Benjamin P Steil; Fiscal Year: 2010
    ..adjuvants (such as nVRPs) that can improve both existing and new vaccines to diseases such as tuberculosis, HIV, dengue virus and hepatitis C virus...
  33. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2011
    ..In this project, we will investigate the mechanisms by which 2 arboviruses with important public health impacts, dengue (DENV) and chikungunya viruses (CHIKV), emerge from sylvatic cycles in non-human primates in Senegal to circulate ..
  34. A new synergy for flavivirus therapy: RNAi enhancement and viral mutagens
    KATHRYN ALYCE HANLEY; Fiscal Year: 2012
    ..In the last 50 years many flaviviruses, such as dengue, West Nile, and tick-borne encephalitis viruses, have exhibited dramatic increases in incidence, disease severity ..
  35. Examining Human Behavior in Dengue Prevention Efforts in Iquitos, Peru
    VALERIE ANDREA PAZ-SOLDAN; Fiscal Year: 2013
    ..Three years ago I found my niche as a social scientist working on dengue prevention, but I need training and mentorship in this new field to me...
  36. MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiology
    Lee Gehrke; Fiscal Year: 2013
    ..The prototype will offer 1) direct identification of the four different dengue virus serotypes by detecting circulating viral protein NS1, as well as 2) indirect Ebola virus and dengue virus ..
  37. Evolution of interactions between Wolbachia and its hosts: Drosophila model syste
    Michael Turelli; Fiscal Year: 2013
    ..introduce into natural mosquito populations Wolbachia strains that suppress disease-causing viruses (particularly dengue fever)...
  38. Nanocapsule-mediated topical delivery of VLP-generating Dengue DNA vaccine
    Gretchen M Unger; Fiscal Year: 2013
    ..by applicant): The ultimate goal of this project is to develop a safe and effective topical vaccine against the dengue virus (DENV)...
  39. Metagenomic detection of emerging viruses in the blood supply
    Eric L Delwart; Fiscal Year: 2013
    ..we will analyze 2000 plasma specimens collected from blood donors in Honduras and Brazil during outbreaks of dengue virus and from 200 WNV RNA+ blood donors from the US...
  40. Ultraviolet light sensing by cryptochrome
    Todd C Holmes; Fiscal Year: 2013
    ..afflict hundreds of millions people worldwide and some insect-mediated diseases such as West Nile virus and dengue fever are alarmingly on the rise in the U...
  41. Regulation of reovirus induced apoptosis
    John S Parker; Fiscal Year: 2012
    ..Many pathogenic human viruses, e.g., dengue virus, influenza virus, and West Nile virus, cause disease by inducing apoptosis...
  42. Dengue Virus Genome Encapsidation and Its Interplay with Host Lipid Droplets
    Andrea Gamarnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus, a member of the Flaviviridae family, is a Category A pathogen that causes the most prevalent arthropod-borne viral illnesses in humans...
  43. Dengue diagnostics using a novel peroxidase chain reaction (PxCR)
    PETER PETER ZASSENHAUS; Fiscal Year: 2013
    ..In this proposal we focus on using PxCR to develop diagnostics for dengue virus...
  44. Broad Detection of Infectious Agents in Blood by Microarrays and Deep Sequencing
    CHARLES YEN CHIU; Fiscal Year: 2013
    ..associated with the most common bloodborne infections, including malaria, Chagas disease, HIV, hepatitis B/C, and dengue virus...
  45. Manipulation of stem cell activity and cell death by intracellular bacteria
    Horacio M Frydman; Fiscal Year: 2013
    ..affect mosquito reproduction and inhibit the ability of several pathogens to infect mosquitoes, including Dengue, Chikungunya, West Nile Virus, and both chicken and human plasmodium...
  46. Role of TRIM79 in innate immunity to tick-borne encephalitis virus
    ROGER TRAVIS TAYLOR; Fiscal Year: 2013
    ..The flaviviruses represent a tremendous disease burden to humans, including dengue virus, West Nile virus (WNV) and tick-borne encephalitis virus (TBEV)...
  47. MODULATION OF INNATE AND ADAPTIVE IMMUNITY BY DENGUE VIRUS
    Ana Fernandez-Sesma; Fiscal Year: 2012
    b>Dengue virus (DenV) is a devastating human pathogen that causes disease and viremia in millions of people worldwide every year. But very little is known about the initiation of immunity by DenV...
  48. Genetic dissection of the RNAi-mediated antiviral immunity in C. elegans
    Shou Wei Ding; Fiscal Year: 2013
    ..Many RNA viruses such as influenza, hepatitis C virus, poliovirus, dengue virus and West Nile virus are important human pathogens...
  49. Slit2N for the Treatment of Viral Hemorrhagic Fever
    ALAN L MUELLER; Fiscal Year: 2012
    ..and mortality has been studied in multiple forms of hemorrhagic fever and it has been well established in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) which are characterized by fever and vascular leakage ..
  50. Development of a Novel, Chimeric Chikungunya Vaccine
    Richard Kinney; Fiscal Year: 2009
    ..Like dengue virus, CHIKV uses humans as amplifying hosts and therefore can disseminate readily in travelers, suggesting that ..
  51. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2012
    b>Dengue virus (DENV) is the most important mosquito-borne viral disease affecting humans today, with an estimated 2.5 billion living in areas at risk for epidemic transmission...
  52. Gene silencing as an antiviral defense in animal cells
    Shou Wei Ding; Fiscal Year: 2013
    ..provided by applicant): RNA viruses include important human pathogens such as hepatitis C, West Nile and dengue viruses and exhibit distinct genetic and immunological properties from DNA viruses...
  53. Development of an autodissemination station for control of mosquito vectors
    Yi Wang; Fiscal Year: 2012
    ..control of urban container-breeding mosquitoes, many of which vector deadly or debilitating diseases, such as dengue, Chikungunya and yellow fever, and also hamper outdoor activity through incessant biting behaviors...
  54. The West Nile virus methyltransferase
    Hongmin Li; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Many flaviviruses cause significant human diseases. Among then, dengue, yellow fever, West Nile, Japanese encephalitis, and tick-borne encephalitis are categorized as the NIAID Priority ..
  55. Altered peptide ligands and immunopathogenesis of dengue virus infection
    ALLISON ANNE IMRIE; Fiscal Year: 2010
    Principal Investigator/Program Director (Last, first, middle): Imrie, Allison 1 R21 AI074831-01A2 Dengue causes significant morbidity and mortality in tropical and subtropical regions, where it is endemic...
  56. Regulation of juvenile hormone titers in mosquitoes
    FERNANDO GABRIEL NORIEGA; Fiscal Year: 2013
    ..Recent dramatic increases in the incidence of mosquito-borne diseases, like malaria and dengue fever, and the wide-spread resistance of mosquitoes to insecticides underscores the need for new approaches for ..
  57. A Study of Heterologous Immunity Induced by Neonatal BCG Vaccination
    Daniel H Libraty; Fiscal Year: 2012
    ..cells (PBMC) and plasma samples that have been collected as part of an ongoing prospective clinical study of dengue virus infections during infancy...
  58. Does Dengue Virus Suppress RNA Interference in its Mosquito Vector?
    KATHRYN ALYCE HANLEY; Fiscal Year: 2010
    ..interaction in the mosquito-borne flaviviruses, which include a number of important emerging pathogens such as dengue, yellow fever and West Nile virus...
  59. Chimeric Alphavirus Vaccines for Chikungunya
    Scott C Weaver; Fiscal Year: 2010
    ..Like dengue virus, CHIKV uses humans as amplifying hosts and therefore can disseminate readily in travelers, suggesting that ..
  60. Dendritic Cell Targeting Enhances Flavivirus Vaccine Efficacy
    Gregg Milligan; Fiscal Year: 2009
    ..Vaccines are needed for multiple flavivirus diseases, most notably dengue, and detailed knowledge of how flaviviruses interact with the innate immune system is critical for vaccine ..
  61. Methyltransferase inhibition assay development
    Bernard Weisblum; Fiscal Year: 2010
    ..In the proposed studies, a Dengue virus-encoded cap-methyltransferase will be used as a model enzyme target that converts the partially methylated ..
  62. Inhibiting Cellular Autophagy to Thwart Dengue Virus Packaging and Replication
    Karla Kirkegaard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus, a category A pathogen, infects 40-100 million people each year...
  63. A Novel Method of Generating Hepatitis C Virus-Like Particles using Lentivirus
    Boro Dropulic; Fiscal Year: 2009
    ..for a wide range of other viral diseases of clinical interest such as hepatitis C, yellow fever, West Nile fever, dengue fever, and influenza...
  64. A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
    Qianjun Li; Fiscal Year: 2007
    ..Several recent human and/or animal epidemics are caused by arboviruses, including Dengue virus (DNV) in Asia, West Nile virus (WNV) in North America and Bluetongue virus (BTV) in Europe...
  65. POPULATION GENETICS OF AEDES AEGYPTI IN THE WEST INDIES
    David Severson; Fiscal Year: 1999
    ..aegypti particularly as it relates to mosquito control measures. Ae. aegypti is the host for Dengue virus as well as yellow fever virus...
  66. YELLOW FEVER 17D-BASED CHIMERIC FLAVIVIRUS VACCINES
    William Wold; Fiscal Year: 2002
    b>Dengue and Japanese encephalitis viruses are important causes of human disease on a global scale and vaccine development against both viruses remains a public health priority...
  67. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..proposal describes several novel technologies directed at the development of a new form of epitope-based dengue genetic vaccine encoding an ensemble of selected antigen peptide units (epitopes) containing the minimum antibody ..
  68. Dengue and West Nile Viral Protease Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2005
    ..family includes human pathogens such as yellow fever virus (YFV), West Nile virus (WNV), and the four serotypes of Dengue (DEN) viruses...
  69. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    b>Dengue virus (DEN), a priority "A" pathogen on the NIH/CDC list of bioterrorism related and emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock ..
  70. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    b>Dengue viruses, members of Flaviviridae, are recognized as the causative agent of mosquito borne viral diseases affecting about 100 million people annually...
  71. Broad-Spectrum Therapeutic Human Antibodies for Dengue Virus Infections
    Yorgo Modis; Fiscal Year: 2006
    ..protein epitopes can prevent and treat infection by several different flaviviruses, including all 4 serotypes of dengue virus and West Nile virus (WNV). Passive immunization is an accepted medical practice to protect against infection...
  72. Vector Surveillance Ontology and Vector Management Ontology
    Saul Lozano Fuentes; Fiscal Year: 2010
    Vector-borne diseases such as dengue and malaria affect hundreds of millions of people each year in subtropical and tropical areas of the world...
  73. Invasive Aedes Mosquitoes and Dengue in Brazil
    Leon Philip Lounibos; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dengue emerged as a serious health problem in the tropical Americas late in the 20th century following the resurgence of Aedes aegypti and the failure of an earlier eradication campaign to quash this ..
  74. The Aedes aegypti Genome Project
    David Severson; Fiscal Year: 2003
    ..For example, the incidence of dengue fever has increased greatly over the past 20 years, recently including its hemorrhagic form with associated human ..
  75. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2004
    DESCRIPTION (adapted from the applicant's abstract): Dengue viruses, members of the Flaviviridae are recognized as the causative agent or one of the most important mosquito-borne viral diseases of humans affecting 100 million people ..
  76. A MODEL SYSTEM FOR PHYSIOLOGICAL EXOCYTOSIS
    FREDRIC COHEN; Fiscal Year: 2009
    ..Viruses that contain these proteins include Dengue, West Nile, almost all encephalitis viruses, and Semliki Forest Virus (SFV)...