ureteral obstruction

Summary

Top Publications

  1. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
  2. ncbi Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, 22908, USA
    Kidney Int 75:1145-52. 2009
  3. pmc Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Misako Sato
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 112:1486-94. 2003
  4. ncbi Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction
    Thomas T Tapmeier
    MRC Centre for Transplantation, King s College London School of Medicine at Guy s, King s and St Thomas Hospitals, London, UK
    Kidney Int 78:351-62. 2010
  5. ncbi Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction
    Kumi Inazaki
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Kidney Int 66:597-604. 2004
  6. ncbi Obstructive nephropathy and renal fibrosis
    Saulo Klahr
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110 1092, USA
    Am J Physiol Renal Physiol 283:F861-75. 2002
  7. ncbi Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction
    Masatoshi Kuratsune
    Department of Molecular and Internal Medicine, Graduate School of Medical Sciences, Hiroshima University, Hiroshima City, Japan
    Nephrology (Carlton) 12:565-71. 2007
  8. ncbi Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction: a P-selectin-mediated event?
    Nelson M Melo-Filho
    Laboratório de Tecido Conjuntivo, Instituto de Bioquimica Medica, and Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
    Am J Physiol Renal Physiol 299:F1299-307. 2010
  9. ncbi Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction
    Vaclav Eis
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 15:337-47. 2004
  10. ncbi Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, 5th Floor MPRB, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Soc Nephrol 16:2373-84. 2005

Research Grants

Detail Information

Publications276 found, 100 shown here

  1. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
  2. ncbi Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, 22908, USA
    Kidney Int 75:1145-52. 2009
    ..The model of unilateral ureteral obstruction (UUO) in the rodent generates progressive renal fibrosis...
  3. pmc Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Misako Sato
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 112:1486-94. 2003
    ..growth factor-beta (TGF-beta) is reportedly upregulated in response to injurious stimuli such as unilateral ureteral obstruction (UUO), causing renal fibrosis associated with epithelial-mesenchymal transition (EMT) of the renal tubules ..
  4. ncbi Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction
    Thomas T Tapmeier
    MRC Centre for Transplantation, King s College London School of Medicine at Guy s, King s and St Thomas Hospitals, London, UK
    Kidney Int 78:351-62. 2010
    ..These cells could be a potential target of therapeutic intervention to prevent excessive fibrosis and loss of function due to renal injury...
  5. ncbi Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction
    Kumi Inazaki
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Kidney Int 66:597-604. 2004
    ..factor-beta (TGF-beta) has been implicated in the development of renal fibrosis induced by unilateral ureteral obstruction (UUO)...
  6. ncbi Obstructive nephropathy and renal fibrosis
    Saulo Klahr
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110 1092, USA
    Am J Physiol Renal Physiol 283:F861-75. 2002
    ..Unilateral ureteral obstruction (UUO) has emerged as an important model for the study of the mechanisms of renal fibrosis and also for the ..
  7. ncbi Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction
    Masatoshi Kuratsune
    Department of Molecular and Internal Medicine, Graduate School of Medical Sciences, Hiroshima University, Hiroshima City, Japan
    Nephrology (Carlton) 12:565-71. 2007
    ..However, the process of STAT activation in vivo remains unclear. This study in rats aimed to localize STAT3 activation within the kidney and examine the in vivo relationship between STAT3 activation and renal fibrosis...
  8. ncbi Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction: a P-selectin-mediated event?
    Nelson M Melo-Filho
    Laboratório de Tecido Conjuntivo, Instituto de Bioquimica Medica, and Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
    Am J Physiol Renal Physiol 299:F1299-307. 2010
    ..echinoderm marine species is reported with the use of a model of renal fibrosis in rats, termed unilateral ureteral obstruction. Animals were given 4 mg/kg body wt of fucosylated chondroitin sulfate intraperitoneally, once a day...
  9. ncbi Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction
    Vaclav Eis
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 15:337-47. 2004
    ..contribute to leukocyte recruitment during renal fibrosis, the authors examined the effects of unilateral ureteral obstruction (UUO) in mice deficient for CCR1 or CCR5...
  10. ncbi Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, 5th Floor MPRB, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Soc Nephrol 16:2373-84. 2005
    ..secreted frizzled-related protein 4 (sFRP4), during renal tubular epithelial injury initiated by unilateral ureteral obstruction (UUO)...
  11. ncbi Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-beta/Smad activity
    Dongshan Zhang
    Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Lab Invest 90:436-47. 2010
    ..study, we investigated if paclitaxel can attenuate tubulointerstitial fibrosis in a rat model of unilateral ureteral obstruction (UUO)...
  12. pmc Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction
    Chuan Zuo
    Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China
    J Zhejiang Univ Sci B 10:380-90. 2009
    ..The present study investigated the potential role of AM on renal fibrosis on a rat model of unilateral ureteral obstruction (UUO)...
  13. ncbi Tissue inhibitor of metalloproteinase-3 plays important roles in the kidney following unilateral ureteral obstruction
    Hidenobu Kawamoto
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Hypertens Res 29:285-94. 2006
    ..on blood pressure and to investigate the role of Timp-3 in the kidney following unilateral ureteral obstruction. The blood pressure and heart rate of Timp-3-deficient mice were not significantly different from those of ..
  14. ncbi Fibroblast activation and myofibroblast generation in obstructive nephropathy
    Maria T Grande
    Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca 37007, Spain
    Nat Rev Nephrol 5:319-28. 2009
    ....
  15. ncbi Urinary concentration and tissue messenger RNA expression of monocyte chemoattractant protein-1 as an indicator of the degree of hydronephrotic atrophy in partial ureteral obstruction
    Miriam Stephan
    Department of Urology, University of Hamburg, Eppendorf University Hospital, Hamburg, Germany
    J Urol 167:1497-502. 2002
    ..whether the messenger (m)RNA expression and urinary concentration of monocyte chemoattractant protein-1 (MCP-1) correlated with the degree of partial ureteral obstruction, and subsequent hydronephrotic atrophy and interstitial fibrosis.
  16. ncbi Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression
    Emin Ozbek
    Department of Urology, Bezm i Alem Valide Sultan Vakif Gureba Research and Education Hospital, Istanbul, Turkey
    J Endourol 23:1165-73. 2009
    To investigate whether melatonin (MLT) treatment has any protective effect on unilateral ureteral obstruction (UUO)-induced kidney injury in rats.
  17. pmc Blockade of CCR2 ameliorates progressive fibrosis in kidney
    Kiyoki Kitagawa
    Department of Gastroenterology and Nephrology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Am J Pathol 165:237-46. 2004
    ..To achieve this goal, we investigated renal interstitial fibrosis induced by a unilateral ureteral obstruction in CCR2 gene-targeted mice and mice treated with propagermanium or RS-504393, CCR2 inhibitors...
  18. pmc Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
    Hirotaka Fukasawa
    First Department of Medicine and Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Proc Natl Acad Sci U S A 101:8687-92. 2004
    ..Smad-mediated TGF-beta signaling pathway and regulatory mechanisms of inhibitory Smad7 in unilateral ureteral obstruction (UUO) kidneys in mice, a model of progressive tubulointerstitial fibrosis...
  19. pmc Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury
    Hanako Kobayashi
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 188:5106-15. 2012
    ..Global activation of Hif suppressed inflammation and fibrogenesis in mice subjected to unilateral ureteral obstruction, whereas activation of Hif in myeloid cells suppressed inflammation only...
  20. ncbi Prevention of renal interstitial fibrosis via histone deacetylase inhibition in rats with unilateral ureteral obstruction
    Fumitaka Kinugasa
    Department of Applied Pharmacology 1, Applied Pharmacology Research Laboratories, Astellas Pharma Inc, Miyukigaoka 21, Tsukuba, Ibaraki 305 8585, Japan
    Transpl Immunol 23:18-23. 2010
    ..deacetylase (HDAC) inhibitor, on interstitial fibrosis in the injured kidneys of a rat model of unilateral ureteral obstruction. The injured kidneys, harvested on Day 14 following the operation, showed progression of interstitial ..
  21. pmc Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition
    Jizhong Cheng
    Department of Medicine, Beijing Institute of Heart Lung and Blood Diseases, Beijing Anzhen Hospital affiliated to the Capital Medical University, Beijing, China
    Kidney Int 78:668-78. 2010
    ..To identify the mechanisms causing EMT, we used the mouse model of unilateral ureteral obstruction and found a rapid and significant increase in serum- and glucocorticoid-regulated kinase-1 (SGK1) ..
  22. ncbi Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes
    V Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig-Maximilians-University, Munich, Germany
    J Am Soc Nephrol 12:1173-87. 2001
    ..of CC chemokines and their receptors during initiation of tubulointerstitial fibrosis after unilateral ureteral obstruction in C57BL/6 mice...
  23. ncbi Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction
    Yasuhiro Suzuki
    Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 81:865-79. 2012
    ..is known about the interaction between lymphangiogenesis and renal fibrosis, we utilized the rat unilateral ureteral obstruction model to analyze inflammation, fibrosis, lymphangiogenesis, and growth factor expression...
  24. pmc Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney
    Shue Dong Chung
    Department of Urology, Far East Memory Hospital, New Taipei City, Taiwan
    PLoS ONE 7:e47299. 2012
    ..may induce three types of programmed cell death, autophagy, apoptosis and pyroptosis in unilateral ureteral obstruction (UUO) kidney...
  25. ncbi Laparoscopic pyeloplasty with concomitant pyelolithotomy: technique and outcomes
    Robert J Stein
    Department of Urology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Endourol 22:1251-5. 2008
    ..We report our experience with laparoscopic pyelolithotomy at the time of laparoscopic pyeloplasty and compare outcome data with a cohort of patients undergoing laparoscopic pyeloplasty without coexistent stone disease...
  26. ncbi Validation of quantitative BOLD MRI measurements in kidney: application to unilateral ureteral obstruction
    Michael Pedersen
    MR Research Centre, Clinical Institute, Aarhus University, Aarhus, Denmark
    Kidney Int 67:2305-12. 2005
    ..Second, BOLD imaging was applied to kidneys in pigs subjected to acute unilateral ureteral obstruction (UUO) to examine whether this condition is associated with changes in intrarenal oxygenation.
  27. ncbi Congenital ureteropelvic junction obstruction: physiopathology, decoupling of tout court pelvic dilatation-obstruction semantic connection, biomarkers to predict renal damage evolution
    C Alberti
    L D of Surgical Semeiotics University of Parma, Parma, Italy
    Eur Rev Med Pharmacol Sci 16:213-9. 2012
    ....
  28. ncbi Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction
    C L R Belmiro
    Laboratorio de Bioquimica e Biologia Celular de Glicoconjugados, Programa de Glicobiologia, Instituto de Bioquimica Medica, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brasil
    Braz J Med Biol Res 44:624-33. 2011
    ..the effect of porcine intestinal mucosa DS on renal inflammation and fibrosis in mice after unilateral ureteral obstruction (UUO)...
  29. pmc TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis
    Rohan Samarakoon
    Center for Cell Biology and Cancer Research MC 165, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Cell Tissue Res 347:117-28. 2012
    ..Unilateral ureteral obstruction (UUO) is a useful and accessible model to identify mechanisms underlying the progression of renal fibrosis...
  30. pmc Obstructive nephropathy: insights from genetically engineered animals
    Jean Loup Bascands
    INSERM U388, Institut Louis Bugnard, Touluse cedex, France
    Kidney Int 68:925-37. 2005
    ..An increasingly used animal model of obstructive nephropathy is unilateral ureteral obstruction (UUO)...
  31. ncbi Laparoscopic pyeloplasty with concomitant pyelolithotomy
    Sanjay Ramakumar
    Section of Urology, Department of Surgery, University of Arizona, Tucson, Arizona, USA
    J Urol 167:1378-80. 2002
    ..We present our experience with laparoscopic pyeloplasty plus pyelolithotomy in patients in whom stones were not the cause of ureteropelvic junction obstruction...
  32. ncbi Up-regulation of HSP47 in the mouse kidneys with unilateral ureteral obstruction
    T Moriyama
    First Department of Medicine, Osaka University School of Medicine, Faculty of Health and Sport Sciences, Japan
    Kidney Int 54:110-9. 1998
    Unilateral ureteral obstruction (UUO) is a well established experimental model of renal injury leading to interstitial fibrosis. The molecular and cellular mechanism(s) of interstitial fibrosis in UUO are beginning to be elucidated...
  33. pmc The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice
    Sayuri Suzuki
    Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 7:e36249. 2012
    ..We previously reported an increase in Skp2 in progressive nephropathy and amelioration of unilateral ureteral obstruction (UUO) renal injury associated with renal accumulation of p27 in Skp2(-/-) mice...
  34. ncbi Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction
    Neil G Docherty
    Department of Surgery, Conway Institute of Biomolecular and Biomedical Sciences, Univ College Dublin, Belfield, Dublin 4, Republic of Ireland
    Am J Physiol Renal Physiol 290:F4-13. 2006
    ..Several interventions that reduce tubular apoptosis are discussed in terms of their ability to prevent subsequent progression to end-organ damage and fibrosis...
  35. ncbi Unilateral ureteral obstruction in neonatal rats leads to renal insufficiency in adulthood
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 58:1987-95. 2000
    ..We have developed a model of temporary unilateral ureteral obstruction (UUO) in the neonatal rat: One month following the relief of five-day UUO, the glomerular filtration rate (..
  36. ncbi Association of PAX2 with cell apoptosis in unilateral ureteral obstruction rats
    Tian Biao Zhou
    Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
    Ren Fail 34:194-202. 2012
    ..to investigate whether PAX2 was associated with cell apoptosis in the progression of RIF in unilateral ureteral obstruction (UUO) rats...
  37. pmc Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model
    Michael S Forbes
    Dept of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 301:F110-7. 2011
    Unilateral ureteral obstruction (UUO), employed extensively as a model of progressive renal interstitial fibrosis, results in rapid parenchymal deterioration...
  38. pmc Postobstructive regeneration of kidney is derailed when surge in renal stem cells during course of unilateral ureteral obstruction is halted
    H C Park
    Departments of Medicine, Pharmacology, and Pathology, Renal Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Renal Physiol 298:F357-64. 2010
    Unilateral ureteral obstruction (UUO), a model of tubulointerstitial scarring (TIS), has a propensity toward regeneration of renal parenchyma after release of obstruction (RUUO)...
  39. ncbi A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
    Maoyin Pang
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Kidney Int 78:257-68. 2010
    ..In a mouse model of renal interstitial fibrosis induced by unilateral ureteral obstruction, STAT3 was activated, and administration of S3I-201 attenuated both this activation and extracellular ..
  40. ncbi Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat
    Chung Hsin Yeh
    Division of Urology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Neurourol Urodyn 30:472-9. 2011
    Oxidative stress and endoplasmic reticulum (ER) stress may induce renal apoptosis and contribute to the pathogenesis of the kidney with unilateral ureteral obstruction (UUO).
  41. pmc Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction
    Veronika Skuginna
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e19204. 2011
    ..Together, postobstructive renal interstitial fibrosis and tubular atrophy develop independent of SIGIRR, TLR2, TLR9, and MyD88. These data argue against a significant role of these molecules in renal fibrosis...
  42. ncbi Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
    M J Wu
    Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Kidney Int 69:2029-36. 2006
    Unilateral ureteral obstruction (UUO) is a well-characterized hydronephrosis model exhibiting interstitial inflammatory-cell infiltration and tubular dilatation followed by tubulointerstitial fibrosis of the obstructed kidney...
  43. ncbi Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
    Arthur C K Chung
    Department of Medicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China
    Nephrol Dial Transplant 24:1443-54. 2009
    ..The present study tested the hypothesis that disruption of Smad7 function may accelerate renal fibrosis and inflammation...
  44. ncbi DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition
    Debra F Higgins
    Department of Medicine and Therapeutics, University College Dublin, Dublin, Ireland
    Kidney Int 64:2079-91. 2003
    ..Here we have used DNA microarray technology to monitor the transcriptomic responses to murine unilateral ureteral obstruction (UUO) with a view to identifying molecular modulators of tubulointerstitial fibrosis.
  45. ncbi Laparoscopic pyeloplasty: current status
    Takeshi Inagaki
    The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    BJU Int 95:102-5. 2005
    ..To review current publications and report our results and long-term follow-up of laparoscopic transperitoneal pyeloplasty for pelvi-ureteric junction (PUJ) obstruction...
  46. pmc Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Pathol 163:1261-73. 2003
    ..mice (beta6(-/-)) to determine the role of local TGF-beta1 activation in renal fibrosis in the unilateral ureteral obstruction (UUO) model...
  47. ncbi The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice
    R G Gonçalves
    Lab Multidisciplinar de Pesquisa, Servico de Nefrologia, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil
    Kidney Int 70:1599-606. 2006
    ..the role of these receptors on the inflammatory and fibrogenic response in the kidneys of unilateral ureteral obstruction (UUO), by using P2X7 knockout mice (-/-)...
  48. ncbi A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney
    Liqiang Meng
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034 PR China
    Vascul Pharmacol 47:174-83. 2007
    ..In the present study, we investigated the effects and possible mechanisms of A&A on vasoactivators in the process of renal interstitial fibrosis...
  49. ncbi Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice
    Ping Fu
    Department of Medicine Nephrology, West China Hospital of Sichuan University, Chengdu, China
    J Am Soc Nephrol 17:3105-14. 2006
    ..This study examined the role of Rho kinase in renal fibrosis in the unilateral ureteral obstruction (UUO) model in mice that do not express the ROCK1 gene, a critical downstream mediator of Rho GTPase...
  50. ncbi TGF-beta1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction
    Meeyul Hwang
    Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea
    Exp Mol Pathol 81:48-54. 2006
    ..that the interstitial fibrosis could be prevented by abolishing TGF-beta1 function in unilateral ureteral obstruction (UUO)-induced renal fibrosis...
  51. ncbi Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury
    Takeshi Marumo
    Dept of Clinical Renal Regeneration, and Div of Nephrology and Endocrinology, Dept of Internal Medicine, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Am J Physiol Renal Physiol 298:F133-41. 2010
    ..and determined the effects of HDAC inhibition on the tubulointerstitial injury induced by unilateral ureteral obstruction. The induction of HDAC1 and HDAC2, accompanied by a decrease in histone acetylation was observed in kidneys ..
  52. pmc Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background
    Tipu S Puri
    Section of Nephrology, Department of Medicine, University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Renal Physiol 298:F1024-32. 2010
    ..Unilateral ureteral obstruction (UUO) is a well-described model of renal fibrosis and as such is considered a model of CKD...
  53. ncbi Activation of Erk1/2 and Akt following unilateral ureteral obstruction
    Ana B Rodríguez-Peña
    Departamento de Fisiologia y Farmacologia, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca and Red de Investigación en Enfermedades Renales, RedinRen del Instituto Carlos III, Salamanca, Spain
    Kidney Int 74:196-209. 2008
    Chronic unilateral ureteral obstruction is a well characterized model of renal injury leading to tubulointerstitial fibrosis and distinct patterns of cell proliferation and apoptosis in the obstructed kidney...
  54. ncbi Laparoscopic pyeloplasty for secondary ureteropelvic junction obstruction
    Chandru P Sundaram
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Urol 169:2037-40. 2003
    ..However, little has been written on the application of this technique for secondary ureteropelvic junction obstruction. We report the largest series of secondary ureteropelvic junction obstruction managed by laparoscopic pyeloplasty...
  55. ncbi Losartan modulation on NOS isoforms and COX-2 expression in early renal fibrogenesis in unilateral obstruction
    Walter Manucha
    Catedra de Fisiopatologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Centro Universitario, Mendoza, Argentina
    Kidney Int 65:2091-107. 2004
    ..in the initiation of renal fibrogenesis at a very early stage leading to a rapid progression in unilateral ureteral obstruction (UUO)...
  56. pmc Laparoscopic pyeloplasty and flexible nephroscopy: simultaneous treatment of ureteropelvic junction obstruction and nephrolithiasis
    Adam J Ball
    Department of Urology, University of Miami School of Medicine, Miami, FL 33101, USA
    JSLS 8:223-8. 2004
    ..Therapeutic controversy exists regarding their ideal management. We report our use of flexible nephroscopy during laparoscopic pyeloplasty for caliceal stone removal...
  57. ncbi Renal damage inhibited in mice lacking angiotensinogen gene subjected to unilateral ureteral obstruction
    Yasumitsu Uchida
    Department of Urology, Keio University School of Medicine, Tokyo, Japan
    Urology 74:938-43. 2009
    ..angiotensin II (Ang II) contributes to renal interstitial fibrosis, the inflammatory response, and tubular cell apoptosis and proliferation in unilateral ureteral obstruction using mice genetically deficient in angiotensinogen (Agt(-/-)).
  58. ncbi alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction
    Chunling Li
    The Water and Salt Research Center, Institute of Clinical Medicine, University of Aarhus, Brendstrupgaardsvej, DK 8230 Aarhus N, Denmark
    Am J Physiol Renal Physiol 290:F384-96. 2006
    ..function and expression of aquaporins (AQPs) and Na-K-ATPase in the kidney in response to 24 h of bilateral ureteral obstruction (BUO) or release of BUO (BUO-R)...
  59. ncbi Laparoscopic pyeloplasty using endoscopic GIA stapler for ureteropelvic junction obstruction
    Hidemori Araki
    Department of Urology, Nagoya University Graduate School of Medicine, Tsurumai, Nagoya, Japan
    J Endourol 19:143-6. 2005
    ..To evaluate the efficiency and safety of this procedure using an endoscopic GIA stapler, the clinical outcomes and our procedures are presented...
  60. ncbi A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats
    Hideki Terashima
    Biological Research Laboratories I, R and D Division, Daiichi Sankyo Co, Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Am J Physiol Renal Physiol 299:F792-801. 2010
    ..In unilateral ureteral obstruction (UUO), a well-characterized model of renal fibrosis, the luciferase activity in obstructed kidneys showed a ..
  61. ncbi Biochemical-molecular markers in unilateral ureteral obstruction
    Walter Manucha
    Laboratorio de Fisiología y Fisiopatología Renal, Area de Fisiopatologia, Departamento de Patologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina
    Biocell 31:1-12. 2007
    ..During unilateral ureteral obstruction induced uncoordinated and aberrant growth may lead to the loss of cellular phenotype and apoptosis...
  62. ncbi Complement C5 mediates experimental tubulointerstitial fibrosis
    Peter Boor
    Division of Nephrology, Rheinische Westfälische Technische Hochschule, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 18:1508-15. 2007
    ..Using a combined genetic and pharmacologic approach, C5, in particular C5a, is identified as a novel profibrotic factor in renal disease and as a potential new therapeutic target...
  63. ncbi Creation of ureteropelvic junction obstruction and its correction by chemical glue-assisted laparoscopic dismembered pyeloplasty
    Allen W Chiu
    Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
    J Endourol 17:23-8. 2003
    ..We established a porcine model of ureteropelvic junction (UPJ) obstruction using a laparoscopic technique and assessed the outcome of standard suture-assisted and chemical glue-assisted laparoscopic pyeloplasty...
  64. ncbi Therapeutic effect of retinoic acid on unilateral ureteral obstruction model
    Kazuya Kishimoto
    Department of Nephrology and Rheumatology, Kinki University Faculty of Medicine, Osaka, Japan
    Nephron Exp Nephrol 118:e69-78. 2011
    ..We investigated the therapeutic effect of all-trans-retinoic acid (ATRA) on unilateral ureteral obstruction (UUO) model mice.
  65. ncbi Effects of nitric oxide on renal interstitial fibrosis in rats with unilateral ureteral obstruction
    Dong Sun
    Department of Nephrology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, PR China
    Life Sci 90:900-9. 2012
    ..Mounting evidence shows that nitric oxide (NO) plays an important role in angiogenesis. Therefore, we investigated to the effects of NO on kidney angiogenesis and renal fibrosis...
  66. ncbi Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction
    Ae S Lee
    Department of Internal Medicine and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Korea
    Kidney Int 83:50-62. 2013
    ..Here we investigated lymphangiogenesis in fibrotic area in unilateral ureteral obstruction, a model of progressive renal fibrosis, and evaluated the roles of vascular endothelial growth factor (VEGF)..
  67. ncbi CD4+ T Lymphocytes, especially Th2 cells, contribute to the progress of renal fibrosis
    Lili Liu
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, PR China
    Am J Nephrol 36:386-96. 2012
    ..But the role of CD4+ T lymphocytes in renal fibrosis is controversial and its cellular mechanism needs to be further investigated...
  68. ncbi Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction
    Shin ichi Satoh
    Institute of Life Science Research, Asahi Kasei Corporation, 632 1, Mifuku, Ohito cho, Tagata gun, Shizuoka 410 2321, Japan
    Eur J Pharmacol 455:169-74. 2002
    ..effects of the Rho-kinase inhibitor, fasudil, on the progression of renal failure in rats with unilateral ureteral obstruction. The renal failure markers monitored were the extent of renal interstitial fibrosis and that of macrophage ..
  69. ncbi Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
    Junwei Yang
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 13:2464-77. 2002
    ..These findings may provide the basis for designing future therapeutic regimens for blocking progressive renal fibrosis in patients...
  70. ncbi Evaluation of pelvic contractility in ureteropelvic junction obstruction: an experimental study
    S Ekinci
    Department of Paediatric Surgery, Hacettepe University Medical Faculty, Ankara, Turkey
    Eur J Pediatr Surg 14:93-9. 2004
    ..Thus, an experimental study was designed to determine the alterations of renal pelvic contractility in response to partial and complete UPJ obstruction...
  71. ncbi Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction
    Paramit Chowdhury
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, UK
    Nephron Exp Nephrol 115:e122-30. 2010
    ..We hypothesised that following injury, TLRs on renal tubular cells are activated by these endogenous ligands, resulting in cytokine production and cellular infiltration which propagate the fibrotic process...
  72. ncbi Erythropoietin attenuates renal injury in an experimental model of rat unilateral ureteral obstruction via anti-inflammatory and anti-apoptotic effects
    Yoon Kyung Chang
    Department of Nephrology, Catholic University Daejeon St Mary Hospital, Daejeon, Republic of Korea
    J Urol 181:1434-43. 2009
    ..We examined whether erythropoietin also attenuates renal injury in a rat model of unilateral ureteral obstruction via anti-apoptotic and anti-inflammatory actions.
  73. ncbi Pathophysiology of unilateral ureteral obstruction: studies from Charlottesville to New York
    E Darracott Vaughan
    James Buchanan Brady Department of Urology, Weill Cornell Medical College, New York, New York, USA
    J Urol 172:2563-9. 2004
    ..30 years ago the decreased renal blood flow and glomerular filtration rate characteristic of unilateral ureteral obstruction (UUO) was described...
  74. ncbi Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction
    Maher El Chaar
    Dept of Urology, Weill Cornell Medical College, Box 94, 1300 York Ave, New York, NY 10021, USA
    Am J Physiol Renal Physiol 292:F1291-301. 2007
    In unilateral ureteral obstruction (UUO), the kidney is characterized by increased fibrosis and apoptosis...
  75. ncbi The expression of Cajal cells at the obstruction site of congenital pelviureteric junction obstruction and quantitative image analysis
    Xinghai Yang
    Department of Pediatric Surgery, Hubei Women and Children s Hospital, Wuhan 430070, People s Republic of China
    J Pediatr Surg 44:2339-42. 2009
    ..The study aimed to analyze the expression and significance of interstitial cells of Cajal (ICC) at the obstruction site of congenital pelviureteric junction obstruction (PUJO)...
  76. ncbi Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor
    Shuei Liong Lin
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Am Soc Nephrol 16:2702-13. 2005
    ..fibrosis, myofibroblasts accumulation, and expression of CTGF and Col I (alpha1) in unilateral ureteral obstruction kidneys. The mechanism by which PTX reduced CTGF in NRK-49F and NRK-52E was investigated...
  77. ncbi Laparoendoscopic single-site pyeloplasty: a comparison with the standard laparoscopic technique
    Robert J Stein
    Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA
    BJU Int 107:811-5. 2011
    ..To compare laparoendoscopic single-site (LESS) and standard laparoscopic pyeloplasty procedures with the aim of defining whether perioperative, recovery or health-related quality of life (HRQL) benefits exist for the LESS procedure...
  78. ncbi Long-term outcomes and late complications of laparoscopic nephrectomy with renal autotransplantation
    Michael L Eisenberg
    Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
    J Urol 179:240-3. 2008
    ..We report long-term outcomes and late complications after laparoscopic nephrectomy with autotransplantation...
  79. ncbi Retrograde ureteral stents for extrinsic ureteral obstruction: nine years' experience at University of Michigan
    Henry M Rosevear
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Urology 70:846-50. 2007
    To review our experience with retrograde ureteral stenting for extrinsic ureteral obstruction because previous reports have suggested only moderate success.
  80. ncbi Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction
    Valeria Solari
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Urol 170:2420-2. 2003
    ..We investigated the expression of c-kit positive cells in the muscle layer of normal and obstructed UPJ specimens...
  81. ncbi Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    Pediatr Nephrol 25:687-97. 2010
    ..Advances will depend on new biomarkers to evaluate the severity of obstruction, to determine therapy, and to follow the evolution of lesions...
  82. pmc The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO)
    Martin E Rinaldi Tosi
    Área de Farmacología y Toxicología, Departamento de Farmacia, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Cell Stress Chaperones 16:57-68. 2011
    ..Rats were subjected to unilateral ureteral obstruction or sham operation and kidneys harvested at 5, 7, 10, and 14 days after obstruction...
  83. ncbi Retrograde ureteroscopic holmium laser endopyelotomy in a selected population of patients with ureteropelvic junction obstruction
    Nicolaj M Stilling
    Department of Urology, Hospital Littlebaelt, Fredericia, Denmark
    Scand J Urol Nephrol 43:68-72. 2009
    ..Significant controversy remains concerning the best way to treat ureteropelvic junction obstruction (UPJO). This study evaluates subjective and objective outcomes of retrograde holmium laser endopyelotomy in a selected population with UPJO...
  84. ncbi The effects of ureteral obstruction on Cajal-like cells in rats
    Baris Kuzgunbay
    Department of Urology, Cukurova University, Adana 01330, Turkey
    J Pediatr Urol 5:269-73. 2009
    To determine the changes in number and morphology of interstitial cells of Cajal (ICC)-like cells (ICC-LC) at the ureteropelvic junction (UPJ) of rats after experimental distal ureteral obstruction.
  85. ncbi Interleukin-18 stimulates a positive feedback loop during renal obstruction via interleukin-18 receptor
    Brian A VanderBrink
    Department of Urology, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202, USA
    J Urol 186:1502-8. 2011
    ..We hypothesized that interleukin-18 stimulates a positive feedback loop during obstruction via interleukin-18 receptor to increase interleukin-18 gene expression and protein production...
  86. ncbi Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo
    Naoya Morisada
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    J Pharmacol Sci 114:379-89. 2010
    ..We addressed this point in mice lacking all NOSs. Renal injury was induced by unilateral ureteral obstruction (UUO)...
  87. pmc IL-18 mediates proapoptotic signaling in renal tubular cells through a Fas ligand-dependent mechanism
    Hongji Zhang
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Renal Physiol 301:F171-8. 2011
    ..This study reveals that IL-18 is a significant mediator of obstruction-induced tubular cell apoptosis, and it demonstrates that IL-18 stimulates proapoptotic signaling through a FasL-dependent mechanism...
  88. ncbi Transplantation of endothelial progenitor cells alleviates renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction
    Yan Yan Ma
    Department of Nephrology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, PR China
    Life Sci 86:798-807. 2010
    The present study investigated whether transplantation of bone marrow-derived endothelial progenitor cells (BM-EPCs) in renal capillary network improves renal interstitial fibrosis in unilateral ureteral obstruction (UUO) model in mice.
  89. ncbi A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren
    Wen Pyng Wu
    Graduate Institute of Clinical Medical Science, China Medical University, China
    Am J Physiol Renal Physiol 299:F929-41. 2010
    ..effects of the combination of valsartan and aliskiren against renal fibrosis induced by unilateral ureteral obstruction (UUO)...
  90. ncbi Early induction of osteoactivin expression in rat renal tubular epithelial cells after unilateral ureteral obstruction
    Atsushi Nakamura
    Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama shi, Saitama, Japan
    Exp Toxicol Pathol 59:53-9. 2007
    In this study, we examined the expression of osteoactivin in the rat kidney after unilateral ureteral obstruction. Male Wistar rats were sacrificed at 6h, and on days 1, 2, 3 and 7 after the obstruction...
  91. pmc Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis
    Yi Chun Yeh
    tDepartment of Medicine, Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Skeleton Joint Research Center, Tainan 70101, Taiwan
    Am J Pathol 177:1743-54. 2010
    ..Furthermore, induction of unilateral ureteral obstruction triggered increases of β(1) integrin in both renal epithelial and interstitial cells...
  92. pmc Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis
    Na Liu
    Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, China
    J Am Soc Nephrol 23:854-67. 2012
    ..Here, after unilateral ureteral obstruction (UUO), wild-type mice exhibited sustained EGFR phosphorylation in the kidney and developed renal fibrosis ..
  93. ncbi Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction
    Kwon Moo Park
    Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:2040-9. 2002
    Protection against ischemic kidney injury is afforded by 24 h of ureteral obstruction (UO) applied 6 or 8 days prior to the ischemia...
  94. ncbi Altered expression of genes profiles modulated by a combination of Astragali Radix and Angelicae Sinensis Radix in obstructed rat kidney
    Liqiang Meng
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Planta Med 76:1431-8. 2010
    ..Ninety-six male Wistar rats were divided randomly into sham, SAA (sham + A&A), UUO (unilateral ureteral obstruction), and UAA (UUO + A&A) groups...
  95. ncbi Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction
    Katsuyuki Nagatoya
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, and School ofHealth and Sport Sciences, Osaka University, Osaka, Japan
    Kidney Int 61:1684-95. 2002
    ..These actions of Rho mediated by downstream Rho effectors such as Rho-associated coiled-coil forming protein kinase (ROCK) may be partly responsible for the progression of renal interstitial fibrosis...
  96. ncbi Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction
    Reiko Sunami
    Okayama Univ Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Physiol Renal Physiol 286:F1030-8. 2004
    ..The effect of catalase deficiency on renal tubulointerstitial injury induced by unilateral ureteral obstruction (UUO) has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) compared with wild-type ..
  97. ncbi Stented versus nonstented pediatric pyeloplasty: a modern series and review of the literature
    Karen E Smith
    Division of Urology, Albany Medical College, Department of Urology, University of California San Francisco Medical Center, San Francisco, California, USA
    J Urol 168:1127-30. 2002
    ..We compared stented versus nonstented repairs in a modern series...
  98. pmc A prospective comparison of robotic and laparoscopic pyeloplasty
    Richard E Link
    James Buchanan Brady Urological Institute and Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg 243:486-91. 2006
    ..To determine whether robotic-assisted pyeloplasty (RLP) has any significant clinical or cost advantages over laparoscopic pyeloplasty (LP) for surgeons already facile with intracorporeal suturing...
  99. ncbi Urinary and serum carbohydrate antigen 19-9 as a biomarker in ureteropelvic junction obstruction in children
    Abdol Mohammad Kajbafzadeh
    Pediatric Urology Research Center, Department of Urology, Pediatric Center of Excellence, Children s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Urol 183:2353-60. 2010
    ..We evaluated the predictive role of serum and urinary carbohydrate antigen 19-9 in the diagnosis and followup of pediatric ureteropelvic junction obstruction...
  100. pmc HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis
    Aparna Vidyasagar
    Nephrology Section, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53713, USA
    Am J Physiol Renal Physiol 295:F707-16. 2008
    ..We first examined its expression in the rat unilateral ureteral obstruction (UUO) model of kidney fibrosis and epithelial-to-mesenchymal transition (EMT)...
  101. ncbi Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway
    Jin Hyun Kim
    Department of Internal Medicine, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Chilam dong 92, Jinju, Gyeongnam 660 751, Republic of Korea
    J Am Soc Nephrol 17:1373-81. 2006
    ..study examined the functional significance of heme oxygenase-1 (HO-1) expression on renal injury induced by ureteral obstruction in the rat kidney...

Research Grants62

  1. Role of PPARalpha in acute kidney injury
    Didier Portilla; Fiscal Year: 2013
    ..and reduced interstitial fibrosis in PPARalpha Tg mice subjected to both unilateral ischemia and Unilateral Ureteral Obstruction (UUO), when compared to wild type mice...
  2. Microvascular Endothelial Cells in the Pathogenesis of Chronic Kidney Injury
    Ikuyo Yamaguchi; Fiscal Year: 2011
    ..Preliminary data show that levels of VE-cadherin and PIGF are increased in the unilateral ureteral obstruction (UUO) model of chronic renal injury...
  3. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
    ..Using a model of progressive renal fibrosis (unilateral ureteral obstruction (DUO)) we will study the role of mast cell renin and local ANG II production in this process as well as ..
  4. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA'AYAN; Fiscal Year: 2013
    ..HIPK2 knockout mice are protected from the development of tubulointerstitial injury in the unilateral ureteral obstruction model and by assessing the effect of HIPK2 knockout on the development of tubulointerstitial injury in Tg26...
  5. Integrin/TGF-beta Axis in Tubulointerstitial Fibrosis
    Ambra Pozzi; Fiscal Year: 2013
    ..is a negative regulator of TI fibrosis, as integrin [unreadable]1KO mice show increased unilateral ureteral obstruction-induced fibrosis...
  6. Cell Signaling in Developing Epithelia
    Gregory R Dressler; Fiscal Year: 2010
    ..kcp-/- mice proved to be hypersensitive to developing renal interstitial fibrosis in the unilateral ureteral obstruction model and showed decreased recovery and increased scarring in an acute nephrotoxicity model...
  7. Role of the M1 macrophage response in the progression of chronic kidney disease
    Steven D Crowley; Fiscal Year: 2013
    ..in M1 KO mice and controls following angiotensin II (Ang II)- dependent hypertension and unilateral ureteral obstruction (UUO)...
  8. Monobody for Renal Inflammaton
    James W Larrick; Fiscal Year: 2011
    ..For example, the anti-Fc-alphaRI Fab A77 blocks renal inflammation induced by ureteral obstruction or anti-glomerular basement membrane antibodies (Kanamaru 2007a,b;2008)...
  9. Attachment, Targeting and Localization of Galpha Subunits
    Bradley M Denker; Fiscal Year: 2010
    ..In Aim 3, animal models of hypoxia, I/R and ureteral obstruction will be used to determine Ga12/13 activation of Src and Rho pathways in renal tubules...
  10. Cellular and Molecular Mechanisms of Renal Fibrosis
    Yanlin Wang; Fiscal Year: 2013
    ..We have studied the factors initiating and controlling renal fibrosis in a model of ureteral obstruction and have discovered a critical and obligate role for immune-inflammatory dysregulation in the initiation of ..
  11. RENIN-ANGIOTENSIN AND GROWTH IN URETERAL OBSTRUCTION
    ROBERT CHEVALIER; Fiscal Year: 1991
    ..study is to elucidate the role of individual components of the RAS In the renal response to unilateral ureteral obstruction (UUO)...
  12. Elastic biodegradable ureteral stent
    Haesun Park; Fiscal Year: 2009
    ..to allow urine flow until the ureter heals sufficiently to maintain its own integrity and flow or to bypass ureteral obstruction. This process takes approximately 2 weeks, after which non-degradable stents must be removed by a second ..
  13. Selective LPA1 receptor antagonists as agents in prevention of renal fibrosis
    FABIO COHEN TUCCI; Fiscal Year: 2012
    ..will then be evaluated for their ability to prevent the progression of renal fibrosis in a unilateral ureteral obstruction (UUO) animal model...
  14. The Role of Nectin in Congenital Obstructive Nephropathy
    PAUL R BRAKEMAN; Fiscal Year: 2010
    ..3) Evaluating the effect of disruption of nectin-1 on apoptosis in the unilateral ureteral obstruction model of congenital obstructive nephropathy...
  15. Ureteral Stent Coatings
    KRISTIN S TATON; Fiscal Year: 2013
    ..of the upper urinary tract and instrumental in management of stone disease, as well as in cases of other ureteral obstruction such as injury, fibrosis or malignancies...
  16. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..bladder tissues that ureteral replacement in a model of total bladder replacement is feasible, without ureteral obstruction or vesicoureteral reflux, and that bioengineered bladders can be emptied efficiently in an intermittent ..
  17. ROLE OF LEUKOCYTES IN OBSTRUCTIVE NEPHROPATHY
    Saulo Klahr; Fiscal Year: 1992
    ..of the cellular infiltrate that occurs in the renal interstitium following acute unilateral or bilateral ureteral obstruction; examine the kinetics of clearance of immune cells from the kidney after the release of obstruction; ..
  18. RENAL GROWTH/DURING URETERAL OBSTRUCTION
    Ihor Sawczuk; Fiscal Year: 1993
    Unilateral ureteral obstruction results in growth of both the obstructed contralateral kidney. In the obstructed kidney, renal tubular cell trophy and cell death follow an initial brief phase of interstitial proliferation...
  19. CORTICAL OSTEOPONTIN EXPRESSION IN HYDRONEPHROSIS
    RUSSELL SCADUTO; Fiscal Year: 2002
    ..The principal investigator hypothesizes that within hours of ureteral obstruction there is increased expression of the renin angiotensin system within the renal cortical proximal tubules...
  20. THE DEVELOPING KIDNEY IN HEALTH AND DISEASE
    Adrian Spitzer; Fiscal Year: 1980
    ..b>Ureteral obstruction is one of the most common congenital abnormalities of the urinary tract in children and is responsible for ..
  21. Ureteral Obstruction: TGF-B & NO in Function & Apoptosis
    Diane Felsen; Fiscal Year: 2004
    Unilateral ureteral obstruction [UUO] with subsequent hydronephrosis is a common clinical occurrence. It affects both men and women and occurs in approximately 1 percent of the pediatric population...
  22. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..for renal injury resulting from urinary tract obstruction are elucidated in models of complete unilateral ureteral obstruction (UUO) in adult animals, the developing kidney responds very differently to obstruction...
  23. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..Following unilateral ureteral obstruction (UUO), there is marked activation of the intrarenal renin-angiotensin system, and heterogeneity in ..
  24. DECORIN--MECHANISMS OF ANTIFIBROTIC EFFECTS
    WAYNE BORDER; Fiscal Year: 2002
    ..to fibrotic disease associated with anti-glomerular basement membrane glomerulonephritis and unilateral ureteral obstruction and whether the susceptibility can be reversed by administration of recombinant decorin 2) Produce ..
  25. Cellular Regulation in Genitourinary Development
    William Steers; Fiscal Year: 2007
    ..study the mediators of both salutary and injurious effects in a newly developed model of neonatal partial ureteral obstruction. A translational research component will search for urinary markers for obstructive nephropathy...
  26. Renal Injury Prevention by SF/HGF-like Small Molecules
    Prakash Narayan; Fiscal Year: 2004
    ..renal dysfunction, we propose to evaluate the in vivo efficacy of C6 in chronic renal disease secondary to ureteral obstruction, renal ischemia, or heavy metal toxicity; determine the proteomic mechanism of action of the C6 in renal ..
  27. RENAL AFFERENTS INVOLVED IN CARDIOVASCULAR REGULATION
    MARK KNUEPFER; Fiscal Year: 1990
    ..ARN) have been implicated in the control of arterial pressure, fluid balance and the intense pain due to ureteral obstruction. Electrical stimulation of ARN elicits reflex changes in arterial pressure and sympathetic hypertension in ..
  28. The Role of Matrix Metalloproteinase-2 in Renal Fibrosis
    Brian Radbill; Fiscal Year: 2005
    ..We plan to test this hypothesis as follows: 1) Compare the degree of fibrosis after unilateral ureteral obstruction in MMP-2 -/- mice versus MMP-2 +/+ mice by measuring collagen content (histologically) and synthesis (real-..
  29. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  30. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  31. Decision Support Systems for MAG3 Renography
    Andrew Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  32. DEVELOPMENT OF TC-99M RENAL TUBULAR AGENTS
    Andrew Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  33. MOLECULAR MECHANISMS IN RENAL INTERSTITIAL FIBROSIS
    Allison Eddy; Fiscal Year: 2008
    ..Finally an alternative as yet unidentified uPA receptor that is up-regulated in the absence of uPAR is proposed to stimulate fibroblast proliferation. The identity of this receptor will be pursued. ..
  34. STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLs
    Stephen Nakada; Fiscal Year: 2005
    ..abstract_text> ..
  35. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
    ..abstract_text> ..
  36. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  37. The Role of BMP-7 in Chronic Kidney Disease
    Keith Hruska; Fiscal Year: 2005
    ..Successful completion of the proposed studies will significantly clarify the usefulness of BMP-7 in CKD, and encourage its development as a new therapeutic agent. ..
  38. FATE OF BF 2 EXPRESSING RENAL PROGENITORS
    Doris Herzlinger; Fiscal Year: 2005
    ..Data generated will provide the basis for future studies on the origin of activated stromal cells in the diseased kidney and their role in nephron degeneration and/or repair. ..
  39. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2006
    ..abstract_text> ..
  40. MATRIX PROTEIN/INTEGRIN MEDIATED OSTEOCLAST REGULATION
    Keith Hruska; Fiscal Year: 2004
    ..Studies in this proposal will be performed in avian and murine osteoclasts that are transduced by fusion proteins containing a human immunodeficiency virus peptide, TAT, which can transduce proteins across cell membranes. ..
  41. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  42. PET IMAGING OF THE 5HT TRANSPORTER IN ALCOHOLISM
    Zsolt Szabo; Fiscal Year: 2003
    ..The results of this project will lead to better understanding of the role of serotonin in the biological vulnerability for alcoholism and may lead to improved approaches to prevent and treat alcoholism. ..
  43. HGF RECEPTOR GENE REGULATION AND RENAL GROWTH
    Youhua Liu; Fiscal Year: 2003
    ..Ultimately, these studies may suggest novel strategies to alter the course of human renal disease by regulating the HGF/c-met axis. ..
  44. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  45. HGF Gene Therapy for Chronic Renal Fibrosis
    Youhua Liu; Fiscal Year: 2009
    ..Ultimately, these studies may lead to development of novel strategies to alter the course of human kidney disease by manipulating the activity of HGF signaling system. ..
  46. Calcineurin in Congenital Urinary Tract Obstruction
    Feng Chen; Fiscal Year: 2009
    ..Results from the proposed studies will provide mechanistic insights into the function of calcineurin in normal and abnormal development of the urinary tract and the etiology of congenital obstructive nephropathy. ..
  47. HGF receptor and renal cell survival and differentiation
    Youhua Liu; Fiscal Year: 2006
    ..knockout mice under normal conditions as well as in chronically injured kidney induced by unilateral ureteral obstruction. These studies will provide fundamental and important insights into understanding the mechanism controlling ..
  48. SHARED INSTRUMENTATION GRANT
    Zsolt Szabo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
  50. ATP-Sensitive K Channels in Renal Proximal Tubule
    Alan Segal; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  52. Hypoxia VHL nad HIF in Renal Tumor Development
    Volker Haase; Fiscal Year: 2008
    ..Ultimately they have the potential to create a murine model of VHL associated renal tumors. ..
  53. The Role of Bone Morphogenetic Protein-7 in Renal Endothelial Cell Biology
    Jeremiah Morrissey; Fiscal Year: 2008
    ..will utilize a reproducible animal model of renal fibrosis the mouse with acute and chronic unilateral ureteral obstruction (UUO)...
  54. ADIPOSE DERIVED STEM CELLS FOR TREATMENT OF INCONTINENCE
    LARISSA RODRIGUEZ; Fiscal Year: 2008
    ..Lastly, we will use an animal model of incontinence and decreased urethral resistance to test the hypothesis that these cells can be used to reconstruct a functional urethra as a treatment of stress incontinence. ..
  55. Endothelin Receptor Imaging of Cancer with PET
    Zsolt Szabo; Fiscal Year: 2007
    ..They have the potential to improve selection of cancer patients for treatment with endothelin antagonists. [unreadable] [unreadable] [unreadable]..
  56. Integrin-linked Kinase and Renal Interstitial Fibrosis
    Youhua Liu; Fiscal Year: 2008
    ..abstract_text> ..
  57. PTEN REGULATION DURING ISCHEMIC ACUTE RENAL FAILURE
    Manjeri Venkatachalam; Fiscal Year: 2008
    ..We will employ PTEN antisense oligonucleotides to suppress kidney PTEN in vivo to study how this intervention affects the course of proximal tubule regeneration and recovery. ..
  58. Center for Pediatric Stem/Progenitor Cell Translational Research
    Alice Tarantal; Fiscal Year: 2008
    ..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
  59. TNF Mediates Obstruction-Induced Renal Injury
    KIRSTAN MELDRUM; Fiscal Year: 2008
    ..and enhance the knowlegde gained by the applicant during her residency and fellowship training to develop a clinically relevant therapeutic approach to the treatment and prevention of obstructive renal injury [unreadable] [unreadable]..
  60. Pediatric Training Program in Chronic Kidney Diseases
    Keith Hruska; Fiscal Year: 2008
    ....