albuminuria

Summary

Summary: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Top Publications

  1. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
  2. ncbi Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
  3. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
  4. pmc Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:93-104. 2011
  5. ncbi The metabolic syndrome and chronic kidney disease in U.S. adults
    Jing Chen
    Tulane University Schools of Medicine and Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Ann Intern Med 140:167-74. 2004
  6. pmc Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes
    Toshiharu Ninomiya
    George Institute for International Health, University of Sydney, Sydney, NSW, Australia
    J Am Soc Nephrol 20:1813-21. 2009
  7. pmc Changes in albuminuria predict mortality and morbidity in patients with vascular disease
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Am Soc Nephrol 22:1353-64. 2011
  8. ncbi Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)
    Amanda I Adler
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, and South Cleveland Hospital, Cleveland, United Kingdom
    Kidney Int 63:225-32. 2003
  9. ncbi Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
    Hans L Hillege
    Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands
    Circulation 106:1777-82. 2002
  10. ncbi Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
    Dick de Zeeuw
    University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Lancet 376:1543-51. 2010

Detail Information

Publications357 found, 100 shown here

  1. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages...
  2. ncbi Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
    ..Kidney damage in many kidney diseases can be ascertained by the presence of albuminuria, defined as albumin-to-creatinine ratio >30 mg/g in two of three spot urine specimens...
  3. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ..assay provide a basis for estimating the prevalence and distribution of chronic kidney disease (CKD) in the United States using standardized criteria based on estimated glomerular filtration rate (GFR) and persistent albuminuria.
  4. pmc Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:93-104. 2011
    Both a low estimated glomerular filtration rate (eGFR) and albuminuria are known risk factors for end-stage renal disease (ESRD)...
  5. ncbi The metabolic syndrome and chronic kidney disease in U.S. adults
    Jing Chen
    Tulane University Schools of Medicine and Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Ann Intern Med 140:167-74. 2004
    ..The metabolic syndrome is a common risk factor for cardiovascular disease...
  6. pmc Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes
    Toshiharu Ninomiya
    George Institute for International Health, University of Sydney, Sydney, NSW, Australia
    J Am Soc Nephrol 20:1813-21. 2009
    There are limited data regarding whether albuminuria and reduced estimated GFR (eGFR) are separate and independent risk factors for cardiovascular and renal events among individuals with type 2 diabetes...
  7. pmc Changes in albuminuria predict mortality and morbidity in patients with vascular disease
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Am Soc Nephrol 22:1353-64. 2011
    The degree of albuminuria predicts cardiovascular and renal outcomes, but it is not known whether changes in albuminuria also predict similar outcomes...
  8. ncbi Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)
    Amanda I Adler
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, and South Cleveland Hospital, Cleveland, United Kingdom
    Kidney Int 63:225-32. 2003
    ..This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death...
  9. ncbi Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
    Hans L Hillege
    Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands
    Circulation 106:1777-82. 2002
    ..Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population...
  10. ncbi Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
    Dick de Zeeuw
    University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Lancet 376:1543-51. 2010
    ..RAAS) inhibitors, patients with diabetes have increased risk of progressive renal failure that correlates with albuminuria. We aimed to assess whether paricalcitol could be used to reduce albuminuria in patients with diabetic ..
  11. ncbi Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts
    Marije van der Velde
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 79:1341-52. 2011
    ..risk, but data on the independent and combined associations of estimated glomerular filtration rate (eGFR) and albuminuria with all-cause and cardiovascular mortality are limited...
  12. ncbi Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes
    Hermann Haller
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    N Engl J Med 364:907-17. 2011
    ..We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria...
  13. pmc Renal and retinal effects of enalapril and losartan in type 1 diabetes
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 361:40-51. 2009
    ..Nephropathy and retinopathy remain important complications of type 1 diabetes. It is unclear whether their progression is slowed by early administration of drugs that block the renin-angiotensin system...
  14. pmc Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes: the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study
    Anna Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes Care 35:143-9. 2012
    ..predictor of cardiovascular disease (CVD), other studies suggested that it confers a much lower risk than albuminuria alone, whereas the combination of the two abnormalities is associated with multiplicative risk...
  15. ncbi Risk factors for renal dysfunction in type 2 diabetes: U.K. Prospective Diabetes Study 74
    Ravi Retnakaran
    Diabetes Trial Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Diabetes 55:1832-9. 2006
    ..K. Prospective Diabetes Study (UKPDS) participants, prospective analyses were undertaken in those without albuminuria (n = 4,031) or with normal plasma creatinine (n=5,032) at diagnosis...
  16. ncbi Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    Katalin Susztak
    Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Diabetes 55:225-33. 2006
    ....
  17. pmc CUBN is a gene locus for albuminuria
    Carsten A Böger
    Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany
    J Am Soc Nephrol 22:555-70. 2011
    Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes...
  18. ncbi Diabetic nephropathy: diagnosis, prevention, and treatment
    Jorge L Gross
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes Care 28:164-76. 2005
    ....
  19. pmc Development and progression of renal insufficiency with and without albuminuria in adults with type 1 diabetes in the diabetes control and complications trial and the epidemiology of diabetes interventions and complications study
    Mark E Molitch
    Northwestern University, Chicago, Illinois, USA
    Diabetes Care 33:1536-43. 2010
    ..73 m(2) in type 1 diabetes up to year 14 of the Epidemiology of Diabetes Interventions and Complications (EDIC) study (mean duration of 19 years in the Diabetes Control and Complications Trial [DCCT]/EDIC)...
  20. ncbi Microalbuminuria: marker or maker of cardiovascular disease
    Ahmed H Abdelhafiz
    Department of Elderly Medicine, Rotherham General Hospital, Rotherham, UK ahmedhafiz hotmail com
    Nephron Exp Nephrol 119:e6-10. 2011
    Advancing age is associated with albuminuria and vascular changes. This review will explore the putative links between the two...
  21. ncbi Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear.
  22. ncbi Microvascular complications assessment in adolescents with 2- to 5-yr duration of type 1 diabetes from 1990 to 2006
    Yoon Hi Cho
    Institute of Endocrinology and Diabetes, The Children s Hospital at Westmead, NSW, Australia
    Pediatr Diabetes 12:682-9. 2011
    ..We therefore investigated trends in prevalence of early microvascular complications over 17 yr...
  23. pmc Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
    Brad C Astor
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 79:1331-40. 2011
    We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD)...
  24. pmc Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function
    Mariana Murea
    Department of Medicine Nephrology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Kidney Int 78:514-22. 2010
    ..Hence, our results raise the possibility that Notch pathway activation is a common mechanism in the pathophysiology of a wide range of acquired renal diseases...
  25. ncbi Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals.
  26. ncbi Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    Proteinuria or albuminuria is an established risk marker for progressive renal function loss. Albuminuria can be effectively lowered with antihypertensive drugs that interrupt the renin-angiotensin system (RAS)...
  27. pmc Adiponectin regulates albuminuria and podocyte function in mice
    Kumar Sharma
    Translational Research in Kidney Disease, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0711, La Jolla, California 92093 0711, USA
    J Clin Invest 118:1645-56. 2008
    Increased albuminuria is associated with obesity and diabetes and is a risk factor for cardiovascular and renal disease. However, the link between early albuminuria and adiposity remains unclear...
  28. pmc Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality
    Carmen A Peralta
    Department of Medicine, San Francisco VA Medical Center, San Francisco, California, USA
    JAMA 305:1545-52. 2011
    ..A triple-marker approach for chronic kidney disease (CKD) evaluation has not been well studied...
  29. pmc RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
    Thoralf M Wendt
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Pathol 162:1123-37. 2003
    ..By age 27 weeks, soluble RAGE-treated db/db mice displayed diminished albuminuria and glomerulosclerosis, and improved renal function...
  30. ncbi Microalbuminuria as an early marker for cardiovascular disease
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 17:2100-5. 2006
    ..is related to the risk for the individual to develop cardiovascular (CV) disease: Absence or very low levels of albuminuria is associated with low CV risk, whereas the CV risk increases markedly with increasing amount of albumin in the ..
  31. ncbi 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98117, USA
    Am J Kidney Dis 50:69-77. 2007
    b>Albuminuria is a risk factor for chronic kidney disease progression, end-stage renal disease, cardiovascular events, and mortality. Animal studies suggested that vitamin D insufficiency may contribute to the pathogenesis of albuminuria.
  32. pmc Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria
    Chunsun Dai
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 20:1997-2008. 2009
    ..Overexpression of Wnt1 in vivo activated glomerular beta-catenin and aggravated albuminuria and adriamycin-induced suppression of nephrin expression, whereas blockade of Wnt signaling with Dickkopf-1 ..
  33. pmc Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis
    Dorothea Nitsch
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMJ 346:f324. 2013
    To assess for the presence of a sex interaction in the associations of estimated glomerular filtration rate and albuminuria with all-cause mortality, cardiovascular mortality, and end stage renal disease.
  34. ncbi Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria
    Masanori Abe
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 34:268-73. 2011
    ..and randomized trial to compare the effects of benidipine with those of amlodipine on blood pressure (BP), albuminuria and aldosterone concentration in hypertensive patients with mild-to-moderate stage chronic kidney disease (CKD)...
  35. ncbi Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability
    Andrew H J Salmon
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Pathol 226:562-74. 2012
    ..glycocalyx alters the permeability of multiple capillary beds: in the glomerulus this is clinically apparent as albuminuria. Generalized damage to the endothelial glycocalyx can therefore manifest as both albuminuria and increased ..
  36. pmc Albuminuria and racial disparities in the risk for ESRD
    William M McClellan
    Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA 30220, USA
    J Am Soc Nephrol 22:1721-8. 2011
    ..4-fold (95% CI 0.9 to 2.3) higher risk for ESRD. In conclusion, the increased prevalence of albuminuria may be an important contributor to the higher risk for ESRD experienced by African Americans.
  37. ncbi Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice
    Hui John Zhao
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C 3121 MCN, Nashville, TN 37232, USA
    J Am Soc Nephrol 17:2664-9. 2006
    ..hyperglycemia was similar to C57BLKS/J db/db mice, by 26 wk, eNOS(-/-) C57BLKS/J db/db mice exhibited dramatic albuminuria, arteriolar hyalinosis, increased glomerular basement membrane thickness, mesangial expansion, mesangiolysis, ..
  38. pmc Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease
    Mohamed E Suliman
    Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Divisions of Renal Medicine and Baxter Novum, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin J Am Soc Nephrol 3:976-85. 2008
    b>Albuminuria and inflammation predict cardiovascular events. Pentraxin 3, an inflammatory mediator produced by, among others, endothelial cells, may have a role in atherogenesis.
  39. ncbi Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms
    Coen D A Stehouwer
    Department of Medicine, Division of General Internal Medicine, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    J Am Soc Nephrol 17:2106-11. 2006
    ....
  40. ncbi Patterns of renal injury in NIDDM patients with microalbuminuria
    P Fioretto
    Department of Internal Medicine, University of Padova Medical School, Italy
    Diabetologia 39:1569-76. 1996
    ....
  41. ncbi Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity
    H L Hillege
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    J Intern Med 249:519-26. 2001
    ..Some of these associations were already observed at albuminuria levels of 10-20 mg L-1...
  42. ncbi Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Epidemiol 168:897-905. 2008
    Screening for albuminuria has been advocated because it is associated with cardiovascular morbidity and all-cause mortality. The "gold standard" to assess albuminuria is 24-hour urinary albumin excretion (UAE)...
  43. ncbi Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial
    Pooneh Alborzi
    Indiana University and VAMC, 1481 W 10th St, Indianapolis, IN 46202, USA
    Hypertension 52:249-55. 2008
    ..To better understand the effects of vitamin D on endothelial function, blood pressure, albuminuria, and inflammation in patients with chronic kidney disease (2 patients stage 2, remaining stage 3), we conducted ..
  44. ncbi Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death
    Coen D A Stehouwer
    Department of Internal Medicine and Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Diabetes 51:1157-65. 2002
    ..dysfunction and chronic inflammation (estimated from plasma markers) can explain the association between (micro)albuminuria and mortality. Of the patients, 113 died...
  45. ncbi Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 18:1353-61. 2007
    ..Together with testing for microalbuminuria, clinical protocols using cystatin C to diagnose early renal function decline and track response to therapeutic interventions should be developed...
  46. ncbi Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes
    Shinichi Okada
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Diabetes 52:2586-93. 2003
    ..Moreover, expressions of TGF-beta and type IV collagen in glomeruli were also suppressed in diabetic ICAM-1(-/-) mice. These results suggest that ICAM-1 is critically involved in the pathogenesis of diabetic nephropathy...
  47. pmc A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis
    K Makibayashi
    Division of Artificial Kidneys and the Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
    Am J Pathol 158:1733-41. 2001
    ..and 1,25(OH)(2)D(3) significantly inhibited mesangial cell proliferation, the degree of glomerulosclerosis, and albuminuria at day 8 compared to the disease control group...
  48. ncbi Microalbuminuria in the US population: third National Health and Nutrition Examination Survey
    Camille A Jones
    Division of Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA, 02215, USA
    Am J Kidney Dis 39:445-59. 2002
    ..In adults aged 40+ years, after excluding persons with clinical proteinuria, albuminuria (defined as ACR > or = 30 mg/g) was independently associated with older age, non-Hispanic black and Mexican ..
  49. ncbi The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 345:870-8. 2001
    ..The primary outcome was the time to the onset of diabetic nephropathy, defined by persistent albuminuria in overnight specimens, with a urinary albumin excretion rate that was greater than 200 microg per minute and ..
  50. pmc Combining GFR and albuminuria to classify CKD improves prediction of ESRD
    Stein I Hallan
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Am Soc Nephrol 20:1069-77. 2009
    ..3 yr of follow-up. In multivariable survival analysis, estimated GFR (eGFR) and albuminuria were independently and strongly associated with progression to ESRD: Hazard ratios for eGFR 45 to 59, 30 to 44, ..
  51. ncbi Renal albumin absorption in physiology and pathology
    H Birn
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
    Kidney Int 69:440-9. 2006
    ..b>Albuminuria has been accepted as an independent risk factor and a marker for renal as well as cardiovascular disease, and ..
  52. ncbi Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross-sectional study and the effects of lisinopril
    S E Nielsen
    Steno Diabetes Center, Gentofte Hospital, Denmark
    Diabet Med 27:1144-50. 2010
    ..lipocalin (NGAL) and kidney injury molecule1 (KIM1) in Type 1 diabetic patients with different levels of albuminuria and in control subjects...
  53. pmc Glomerular and tubular damage markers are elevated in patients with diabetes
    Ferdau L Nauta
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Diabetes Care 34:975-81. 2011
    ..lipocalin [NGAL], and cystatin C), and distal tubular (heart fatty acid-binding protein [H-FABP]) damage markers with kidney disease severity, as assessed by albuminuria and estimated glomerular filtration rate (eGFR).
  54. pmc Estimated GFR, albuminuria, and complications of chronic kidney disease
    Lesley A Inker
    Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 22:2322-31. 2011
    Higher levels of albuminuria associate with increased risk for adverse outcomes independent of estimated GFR (eGFR), but whether albuminuria also associates with concurrent complications specific to chronic kidney disease (CKD) is ..
  55. ncbi Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes
    Dilip K Deb
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Kidney Int 77:1000-9. 2010
    ..Vehicle-treated diabetic mice developed progressive albuminuria and glomerular abnormalities with mesangial expansion and glomerulosclerosis compared to their non-diabetic ..
  56. ncbi Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, Groningen University Medical Center, Ant Deusinglaan 1, 9713 AV Groningen, Netherlands
    Circulation 110:921-7. 2004
    b>Albuminuria is an established risk marker for both cardiovascular and renal outcomes. Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS)...
  57. pmc Low income and albuminuria among REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participants
    Deidra C Crews
    Division of Nephrology, Department of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Am J Kidney Dis 60:779-86. 2012
    b>Albuminuria is an important risk factor for progressive chronic kidney disease (CKD) and is more prevalent in black than white adults...
  58. pmc Associations of diet with albuminuria and kidney function decline
    Julie Lin
    Renal Division, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 5:836-43. 2010
    ..Sparse longitudinal data exist on how diet influences microalbuminuria and estimated GFR (eGFR) decline in people with well-preserved kidney function...
  59. pmc Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, SE 751 85, Uppsala, Sweden
    BMC Res Notes 5:537. 2012
    ....
  60. pmc Increased tubular proliferation as an adaptive response to glomerular albuminuria
    Jian Kan Guo
    Section of Nephrology and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Soc Nephrol 23:429-37. 2012
    ..Ablation of <20% of podocytes resulted in profound albuminuria that resolved over 1-2 weeks after the re-establishment of normal podocyte morphology...
  61. ncbi Serum uric acid is related to cardiovascular events and correlates with N-terminal pro-B-type natriuretic peptide and albuminuria in patients with diabetes mellitus
    M Resl
    Department of Endocrinology, Medical University of Vienna, Vienna, Austria
    Diabet Med 29:721-5. 2012
    ..It correlates to intima-media thickness and microalbuminuria. In this study we evaluated uric acid as an independent marker for cardiac events in patients with diabetes...
  62. ncbi Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    Kidney Int 69:2057-63. 2006
    ..A cross-sectional study evaluating 32,208 type II diabetic patients without known albuminuria from 33 countries was performed...
  63. pmc Albuminuria is associated with too few glomeruli and too much testosterone
    David A Long
    Nephro Urology Unit, UCL Institute of Child Health, London, UK
    Kidney Int 83:1118-29. 2013
    ..Genetic variation and both pre- and postnatal environmental factors may affect albuminuria in humans...
  64. ncbi Prevalence and relationship between diabetic retinopathy and nephropathy, and its risk factors in the North-East of Spain, a population-based study
    Romero Aroca Pedro
    Ophthalmic Service, Hospital Universitario Sant Joan, Universidad Rovira i Virgili, Reus, Spain
    Ophthalmic Epidemiol 17:251-65. 2010
    ..To determine the prevalence of microangiopathy, and its risk factors in a population-based study of diabetes mellitus patients in the north-eastern area of Spain...
  65. ncbi Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
    Eur Heart J 32:1493-9. 2011
    ..is associated with the short-term lowering of its primary target blood pressure, but also with the lowering of albuminuria. Since the individual blood pressure and albuminuria response to an ARB varies between and within an individual,..
  66. ncbi Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes
    Klaus Klausen
    Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark
    Circulation 110:32-5. 2004
    ..Microalbuminuria has been suggested as an atherosclerotic risk factor. However, the lower cutoff level of urinary albumin excretion is unknown. It is also unknown whether impaired renal function confounds the association...
  67. ncbi The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease
    K S Eardley
    Department of Nephrology, Queen Elizabeth Hospital, Birmingham, UK
    Kidney Int 69:1189-97. 2006
    ..We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large ..
  68. ncbi Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    P L Drury
    Auckland Diabetes Centre, New Zealand
    Diabetologia 54:32-43. 2011
    We investigated effects of renal function and albuminuria on cardiovascular outcomes in 9,795 low-risk patients with diabetes in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.
  69. pmc Predictors of incident albuminuria in the Framingham Offspring cohort
    Conall M O'Seaghdha
    Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Kidney Dis 56:852-60. 2010
    Predictors for incident albuminuria are not well known in population-based cohorts. The purpose of this study is to identify predictors of incident albuminuria in an unselected middle-aged population.
  70. ncbi Differential expression of nephrin according to glomerular size in early diabetic kidney disease
    Jin Ju Kim
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemoon Gu, Seoul, Korea 120 752
    J Am Soc Nephrol 18:2303-10. 2007
    ..Furthermore, more hypertrophied glomeruli with lesser nephrin expression may be responsible for albuminuria in the early stage of DN.
  71. ncbi Impact of microalbuminuria on incident stroke: a meta-analysis
    Meng Lee
    Stroke Center and Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Stroke 41:2625-31. 2010
    ..The purpose of this study was to assess the consistency and strength of the association of microalbuminuria with risk of stroke in prospective studies using meta-analysis...
  72. pmc Comparison of estimated glomerular filtration rates and albuminuria in predicting risk of coronary heart disease in a population with high prevalence of diabetes mellitus and renal disease
    Nawar M Shara
    MedStar Health Research Institute, Hyattsville, Maryland, USA
    Am J Cardiol 107:399-405. 2011
    ..The addition of albuminuria to established methods of CHD risk calculation was reported in the Strong Heart Study (SHS) cohort...
  73. ncbi Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes
    S G Sayyed
    Nephrological Center, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Diabetologia 52:2445-54. 2009
    ....
  74. ncbi Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion
    Auke H Brantsma
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3851-8. 2008
    ..In this study we evaluated cardiovascular and renal outcome in subjects with stage 1 and 2 CKD. For comparison, we also studied these outcomes in stage 3 CKD...
  75. pmc Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo
    Liming Wang
    Division of Nephrology, Department of Medicine, Duke University, Durham Veterans Affairs Medical Centers, Durham, North Carolina 27710, USA
    Mol Endocrinol 25:1376-86. 2011
    ..Apoptosis requires NFAT-dependent gene transcription and is mediated, in part, by CN-dependent COX2 induction, prostaglandin E(2) generation, and autocrine activation of the Gq-coupled E-series prostaglandins receptor...
  76. ncbi Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury
    Liming Wang
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    J Am Soc Nephrol 16:3611-22. 2005
    ..Transgenic (TG) mice demonstrated albuminuria as well as a decrease in both kidney mass and nephron number...
  77. ncbi Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes
    Minghao Ye
    Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    J Am Soc Nephrol 17:3067-75. 2006
    ..ACE2 inhibition increases UAE suggests that ACE2, likely by modulating the levels of glomerular angiotensin II via its degradation, may be a target for therapeutic interventions that aim to reduce albuminuria and glomerular injury.
  78. ncbi Estimated glomerular filtration rate and urinary albumin excretion are independently associated with greater arterial stiffness: the Hoorn Study
    Marc M H Hermans
    Department of Internal Medicine, Division of Nephrology, Academic Hospital Maastricht, 6202 AZ Maastricht, Netherlands
    J Am Soc Nephrol 18:1942-52. 2007
    Mild renal insufficiency is a risk factor for cardiovascular disease (CVD). Both a decline in GFR and (micro)albuminuria are associated with greater cardiovascular mortality...
  79. ncbi Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Diabetes 56:380-8. 2007
    ..has previously been implicated in the progression of diabetic nephropathy, including the onset of fibrosis and albuminuria. Here we report for the first time the use of a high-affinity TGF-beta1 binding molecule, the soluble human TGF-..
  80. ncbi Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial
    George L Bakris
    Hypertensive Diseases Unit, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Lancet 375:1173-81. 2010
    ..We assessed the effects of these drug combinations on progression of chronic kidney disease...
  81. ncbi Microalbuminuria, von Willebrand factor and fibrinogen levels as markers of the severity in COPD exacerbation
    Mehmet Polatli
    Department of Pulmonology, Adnan Menderes University Hospital, Aydin, Turkey
    J Thromb Thrombolysis 26:97-102. 2008
    ..We suggest that further studies are necessary to investigate the impact of antithrombotic treatment on microalbuminuria, plasma vWF and fibrinogen as markers of endothelial dysfunction coexisting COPD exacerbation...
  82. ncbi Ambulatory arterial stiffness index and renal abnormalities in primary hypertension
    Elena Ratto
    Department of Cardio Nephrology, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    J Hypertens 24:2033-8. 2006
    ..We investigated the relationship between a recently proposed ambulatory blood pressure monitoring-derived index of arterial stiffness and early signs of renal damage in patients with primary hypertension...
  83. ncbi Low-grade albuminuria is associated with carotid intima-media thickness in Chinese type 2 diabetic patients
    Yun Huang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Endocrinol Metab 95:5122-8. 2010
    Low-grade albuminuria was reported to be associated with cardiovascular risk factors...
  84. pmc Activation of RhoA in podocytes induces focal segmental glomerulosclerosis
    Lei Zhu
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Am Soc Nephrol 22:1621-30. 2011
    ..Induction of activated RhoA with doxycycline resulted in significant albuminuria. Furthermore, both the degree of albuminuria and the histologic changes in the glomerulus positively correlated ..
  85. pmc Risk for ESRD in type 1 diabetes remains high despite renoprotection
    Elizabeth T Rosolowsky
    Section on Genetics and Epidemiology, Research and Clinic Divisions, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 22:545-53. 2011
    ..In conclusion, despite the widespread adoption of renoprotective treatment, patients with type 1 diabetes and macroalbuminuria remain at high risk for ESRD, suggesting that more effective therapies are desperately needed...
  86. ncbi Microalbuminuria and hypoxemia in patients with chronic obstructive pulmonary disease
    Ciro Casanova
    Respiratory Research Unit, Pulmonary Department, Hospital Universitario La Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Am J Respir Crit Care Med 182:1004-10. 2010
    ..There is evidence of vascular dysfunction in patients with chronic obstructive pulmonary disease (COPD)...
  87. ncbi Relation of albuminuria to angiographically determined coronary arterial narrowing in patients with and without type 2 diabetes mellitus and stable or suspected coronary artery disease
    Philipp Rein
    Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
    Am J Cardiol 107:1144-8. 2011
    b>Albuminuria is associated with atherothrombotic events and all-cause mortality in patients with and without diabetes. However, it is not known whether albuminuria is associated with atherosclerosis per se in the same manner...
  88. ncbi Clinical practice. Nephropathy in patients with type 2 diabetes
    Giuseppe Remuzzi
    Unit of Nephrology, Ospedali Riuniti di Bergamo, Italy
    N Engl J Med 346:1145-51. 2002
  89. ncbi Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions
    Tamara Isakova
    Division of Nephrology and Hypertension, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Ren Nutr 21:295-302. 2011
    ..We evaluated the relationship between calcidiol (25D), calcitriol (1,25D), inflammation, and albuminuria in Study of Early Evaluation of Kidney Disease, a multicenter CKD cohort.
  90. pmc Inflammation, kidney function and albuminuria in the Framingham Offspring cohort
    Ashish Upadhyay
    Division of Nephrology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 26:920-6. 2011
    ..Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood.
  91. ncbi CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice
    Young Sun Kang
    Division of Nephrology, Department of Internal Medicine, Korea University, Ansan City, Korea
    Kidney Int 78:883-94. 2010
    ..Hence, our findings suggest that CCR2 antagonists can improve insulin resistance by modulation of the adipose tissue and restore renal function through both metabolic and anti-fibrotic effects in type 2 diabetic mice...
  92. ncbi Risk profile in chronic kidney disease stage 3: older versus younger patients
    Natasha J McIntyre
    Department of Renal Medicine, Royal Derby Hospital, Derby, UK
    Nephron Clin Pract 119:c269-76. 2011
    ..Moreover, subjects ≥75 years are often excluded from research studies. We therefore undertook a prospective study of patients with CKD stage 3 in primary care to compare the risk profile of older versus younger subjects...
  93. ncbi Flow-mediated dilation is associated with microalbuminuria independent of cardiovascular risk factors in type 2 diabetes - interrelations with arterial thickness and stiffness
    Hiroki Yokoyama
    Jiyugaoka Medical Clinic, Internal Medicine, Obihiro, Japan
    J Atheroscler Thromb 18:744-52. 2011
    ....
  94. ncbi Urinary tubular biomarkers in short-term type 2 diabetes mellitus patients: a cross-sectional study
    Wen Jin Fu
    Department of Laboratory, Affiliated Houjie Hospital, Guangdong Medical College, Dongguan, 523945, Guangdong, China
    Endocrine 41:82-8. 2012
    ..In conclusion, these results suggest that tubular damage is common in short-term T2DM patients. Urinary NGAL may be a promising early marker for monitoring renal impairment in short-term T2DM patients...
  95. ncbi Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
    M F Yuyun
    Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    J Intern Med 255:247-56. 2004
    ..To examine the relationship between microalbuminuria and incident stroke in the general population...
  96. pmc Kidney dysfunction and cognitive decline in women
    Imran Sajjad
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 7:437-43. 2012
    ..ESRD is associated with substantial cognitive deficits but whether earlier kidney dysfunction predicts cognitive decline is less well defined...
  97. pmc Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons
    Andy I Choi
    Department of Medicine, San Francisco Veterans Affairs Medical Center, and University of California, San Francisco, USA
    Circulation 121:651-8. 2010
    ..We examined the association between longitudinal measures of kidney function and albuminuria with risk of atherosclerotic CVD and heart failure in a contemporary cohort of HIV-infected individuals.
  98. ncbi Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study
    Johanna W M Nin
    Care and Public Health Research Institute, University of Maastricht, Maastricht, The Netherlands
    Eur J Endocrinol 166:325-32. 2012
    ....
  99. ncbi Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy
    Andrew Advani
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Nephrology (Carlton) 16:573-81. 2011
    ..In the present study we sought to investigate the effects of long-term inhibition of the EGFR tyrosine kinase in an experimental model of diabetes that is characterized by angiotensin II dependent hypertension...
  100. pmc Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Epidemiol 170:1156-64. 2009
    ..survey year, sociodemographic factors, chronic kidney disease risk factors, and blood lead, the odds ratios for albuminuria (>or=30 mg/g creatinine), reduced estimated glomerular filtration rate (eGFR) (<60 mL/minute/1...
  101. ncbi [Methods of collecting urine for the determination of microalbuminuria: time for consensus]
    A J Bakker
    Stichting Klinisch Chemisch Laboratorium, Postbus 850, 8901 BR Leeuwarden
    Ned Tijdschr Geneeskd 148:2012-5. 2004
    ..5 g/mol for men and above 3.5 g/mol for women. If microalbuminuria is detected, the investigation should be repeated at least twice in a period of a few months in order to establish the degree of microalbuminuria...

Research Grants70

  1. New insights in mechanisms of renal injury
    Balakuntalam S Kasinath; Fiscal Year: 2013
    ..in association with renal hypertrophy, increase in renal matrix laminin beta1 and fibronectin expression, and albuminuria. 2...
  2. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in CKD patients and also provide survival benefits for CKD patients...
  3. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..The trial will include a total of 400 T1D patients at high risk for GFR loss because of increased albuminuria and a relatively high serum uric acid (e 4...
  4. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in diabetic nephropathy patients and also provide cardiovascular and survival benefits for CKD patients...
  5. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..in our cohort was associated with greater left ventricular mass index, increased arterial stiffness, greater albuminuria, and nocturnal natriuresis...
  6. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..and coorelate these measures with markers of kidney function (estimated glomerular filtration rate, albuminuria), daytime and nighttime blood pressure, NT-proBNP, cardiac troponins I, and left ventricular geometry and ..
  7. Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study
    Clifford E Kashtan; Fiscal Year: 2013
    ..and (2) to test the hypothesis that in males with Alport syndrome urinary uromodulin excretion decreases as albuminuria and proteinuria increase and that uromodulin offers an independent and insightful measure of renal fibrosis and ..
  8. Chronic kidney disease in survivors of hematopoietic cell transplant
    Sangeeta Hingorani; Fiscal Year: 2012
    ..Using univariable and multivariable Cox regression models, graft vs. host disease, albuminuria, hypertension, post-transplant diabetes and calcinuerin inhibitor use will be analyzed as risk factors for ..
  9. Phenotypes of diabetic kidney disease and the relationship to retinal pathology
    Amy Mottl; Fiscal Year: 2013
    ..The predictive ability of retinopathy severity for albuminuria progression and decline in glomerular filtration rate (GFR) over four years will be analyzed...
  10. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..doxercalciferol, cholecalciferol, and placebo on bone and mineral metabolism, physical strength and function, albuminuria, and kidney function...
  11. The Role of Cyclooxygenase-2 in Podocyte Injury in Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2013
    ..The clinical syndrome of diabetic nephropathy (DN) is comprised of albuminuria, characteristic renal histopathologic changes and decreased renal function...
  12. Molecular Mechanisms of Albumin Trafficking in Podocytes
    Judith T Blaine; Fiscal Year: 2013
    ..b>Albuminuria is one of the key features of chronic kidney disease and a marker of CKD progression...
  13. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..We aim to test whether vitamin D3 and/or omega-3 fatty acids prevent progression of albuminuria and loss of glomerular filtration rate, two complementary manifestations of DKD, over 4 years of treatment...
  14. Ameliorating Sickle Nephropathy and Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..With increasing age, glomerulopathy develops, manifest initially as micro-albuminuria, then macro- albuminuria, progressing to renal failure and end stage renal disease...
  15. The Aging Kidney in HIV-Infection: biomarkers for early detection of injury
    Michael G Shlipak; Fiscal Year: 2013
    ..However, a major challenge in clinical practice is the current reliance on serum creatinine and albuminuria testing to detect kidney injury and disease...
  16. Interactions of Lipoproteins and Cells in Diabetes Mellitus
    RICHARD LOUIS KLEIN; Fiscal Year: 2013
    ..sphingolipid subspecies in VLDL, LDL, HDL2, and HDL3 prepared from Type 2 diabetic patients with and without albuminuria. We will determine if the concentration and distribution in lipoproteins of these additional bioactive lipids ..
  17. Urinary Biomarkers of Chronic Kidney Disease Pathology and Progression
    Sushrut S Waikar; Fiscal Year: 2013
    ..of CKD progression;and that urinary biornarkers are superior to conventional markers (serum creatinine and albuminuria) as predictors of CKD progression...
  18. TNF-like weak inducer of apoptosis (TWEAK) signaling in lupus nephritis
    Chaim Putterman; Fiscal Year: 2013
    ..Determine the effect of TWEAK signaling in resident kidney cells, and particularly podocytes, in the development of LN, including albuminuria and glomerulosclerosis.
  19. Regulation of Podocyte Differentiation by the Transcription Factor EBF1
    Jackie Fretz; Fiscal Year: 2013
    ..form present with dysfunctional vascularization, crescents, severely effaced podocytes, and these mice exhibit albuminuria and elevated blood urea nitrogen...
  20. Impact of Vitamin D on Diabetic Kidney Disease in African Americans
    VANESSA ASTRUD DIAZ; Fiscal Year: 2012
    ..D3 at 400 IU/d versus supplementation of 4000 IU/d) on the proportion of African Americans with progression of albuminuria over 12 months and 2) to identify whether kidney disease risk factors such as blood pressure and glycemic ..
  21. AT1 Receptors in Renal Microvascular Physiology
    LISA HARRISON BERNARD; Fiscal Year: 2009
    ..This chronic and debilitating disease is characterized by progressive albuminuria, declining glomerular filtration rate (GFR), and increased risk for cardiovascular disease, eventually ..
  22. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2012
    ..the association of MYH9 gene polymorphisms with cross-sectional and longitudinal measures of blood pressure, albuminuria, serum cystatin C and creatinine concentrations, and estimated glomerular filtration rates in members of the ..
  23. Endothelial Dysfunction in the Pathogenesis of Sickle Cell Nephropathy
    Kenneth I Ataga; Fiscal Year: 2013
    ..suggests that by inducing endothelial dysfunction, sFLT-1 may play an important role in the development of albuminuria in SCD...
  24. Racial Disparities in Chronic Kidney Disease and Vitamin D: Are they related?
    Michal L Melamed; Fiscal Year: 2011
    ..randomized clinical trial of vitamin D repletion in a multi-ethnic population with CKD, vitamin D deficient and albuminuria to evaluate correction of vitamin D levels, and reductions in albuminuria and blood pressure...
  25. Glomerular Cell-Cell Crosstalk and Injury
    Erwin P Bottinger; Fiscal Year: 2013
    ..When TbrI(AAD) signaling is activated in podocytes, mice eventually develop albuminuria and subsequently progressive glomerulosclerosis associated with podocyte depletion...
  26. Podocytes and oxidative stress in diabetic kidney
    Paul N Epstein; Fiscal Year: 2010
    ..They show a 100 fold increase in albuminuria, extensive interstitial fibrosis and a modest reduction in GFR...
  27. Early-Stage Chronic Kidney Disease in HIV-infected Individuals
    Gregory M Lucas; Fiscal Year: 2013
    ..In the general population, albuminuria is typically the earliest detectable marker of chronic kidney disease (CKD), and even very low levels of ..
  28. Role of TSC-mTORC1 pathway for podocyte injury in diabetic nephropathy
    Ken Inoki; Fiscal Year: 2013
    ..Podocyte injury may produce micro-albuminuria, an early feature of DN. The molecular mechanisms by which diabetes causes podocyte injury remain unclear...
  29. Renal Processing of Albumin
    Oliver Smithies; Fiscal Year: 2010
    ..Correctly understanding the pathogenesis of albuminuria is prerequisite for interpreting its significance in different conditions, and for designing appropriate ..
  30. Vitamin D hormones in CKiD: Prevalence of deficiency and clinical correlates.
    Juhi Kumar; Fiscal Year: 2013
    ..as a potential risk factor for CKD progression, because of their association with higher blood pressure and albuminuria.FGF-23 is a novel hormone that is a negative regulator of 1,25 dihydroxy vitamin D levels and has been shown to ..
  31. Kidney Function, Aortic Stiffness and Aging
    Andrew S Levey; Fiscal Year: 2013
    ..It is well-known that GFR declines and albuminuria increases with aging, and that both are associated, independently and in combination, with an increased risk ..
  32. PDE5i with Tadalafil Changes the Extent of Renal Damage (PITCH_ER)
    Ravi Thadhani; Fiscal Year: 2013
    ..Both chronic kidney disease (CKD) (reflected by albuminuria and reduced glomerular filtration rate [GFR]) and acute kidney injury (AKI) significantly contribute to ..
  33. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2012
    ..hypothesis, we have recently found that ACE2 inhibition using a specific pharmacologic agent, MLN-4760, worsens albuminuria and induces glomerular injury in two different models of nephropathy in diabetic mice...
  34. Development of MASP-2 MoAbs for the treatment of diabetic nephropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2010
    ..Mice will be treated with anti-MASP-2 antibody or isotype control, and effects of antibody treatment on albuminuria, renal function and histological features of DN will be assessed...
  35. Health system based clinical trial recruitment
    Trevor J Orchard; Fiscal Year: 2011
    ..type 1 diabetes cohort, Hp predicted early renal function decline and end-stage renal disease (ESRD) but not albuminuria per se...
  36. AORTA, BRAIN AND KIDNEY STRUCTURE AND FUNCTION IN THE AGES-REYKJAVIK STUDY
    GARY FRANK MITCHELL; Fiscal Year: 2012
    ..with abnormal brain and kidney structure (MRI) and function (cognitive testing, glomerular filtration rate, albuminuria)...
  37. Genomic Medicine Pilot For Hypertension And Kidney Disease In Primary Care
    Carol R Horowitz; Fiscal Year: 2013
    ..renoprotective renin angiotensin blockade, appropriate control of blood pressure in hypertensive patients with albuminuria of African ancestry, will be improved significantly in those facilities that receive EMR-enabled renal care CDS ..
  38. Interactive Spaced Education to Optimize Diabetes Care
    B Price Kerfoot; Fiscal Year: 2013
    ..ARBs) substantially reduce morbidity and mortality in patients with diabetes, particularly in those with albuminuria. Even so, these medications are currently under-prescribed across the United States...
  39. Novel EP receptor antagonists for the treatment of hypertension and of diabetes
    Richard M Breyer; Fiscal Year: 2013
    ..Mice will assessed for changes in blood pressure, and changes in markers of DM including albuminuria, renal function and histopathological changes in the kidney and the heart to examine the effects of EP receptor ..
  40. Proteomic Approach to CKD Biomarker Discovery and Validation
    Josef Coresh; Fiscal Year: 2013
    ..Two biomarkers, serum creatinine and albuminuria, provide the mainstay for staging and risk assessment for the majority of CKD patients...
  41. Stroke and Cognitive Impairment in Aging Chronic Kidney Disease Patients
    Anne M Murray; Fiscal Year: 2013
    ..silent incident stroke, a structured cognitive battery to detect impairment, and laboratory values to assess albuminuria and inflammatory markers, to measure the role of stroke and white matter disease and of factors specific to CKD ..
  42. Novel serum and urinary biomarkers of diabetic kidney disease
    Steven G Coca; Fiscal Year: 2013
    ..We propose that there are better markers to predict CKD in diabetics than albuminuria. These include biomarkers that reflect tubulointerstitial injury, inflammation and fibrosis, and oxidative ..
  43. Prorenin Receptor Mediates Early Changes in Diabetic Kidney
    Helmy M Siragy; Fiscal Year: 2013
    ..there is upregulation of V-ATPase and Wnt3a expression and activity leading to renal inflammation fibrosis and albuminuria. In vivo intrarenal interstitia administration of PRR shRNA or Wnt3a shRNA reduced albuminuria, renal ..
  44. Biological Variation in A1c on Mortality, Cardiovascular Events, Hypoglycemia
    James M Hempe; Fiscal Year: 2012
    ..treatment of dyslipidemia reduced the rate of progression of diabetic retinopathy and delayed the onset of albuminuria. However, these microvascular benefits of intensive management did not clearly outweigh the concomitant ..
  45. Chronic Kidney Disease in Children (CKiD)
    Susan L Furth; Fiscal Year: 2013
    ..the Kidney Disease Improving Global Outcomes (KDIGO) classification of CKD according to Cause, GFR and level of albuminuria, to define risk factors for accelerated and non-linear decline in GFR among strata of children with glomerular ..
  46. Chronic Kidney Disease in Children (CKiD III)
    BRADLEY ALAN WARADY; Fiscal Year: 2013
    ..the Kidney Disease Improving Global Outcomes (KDIGO) classification of CKD according to Cause, GFR and level of albuminuria, to define risk factors for accelerated and non-linear decline in GFR among strata of children with glomerular ..
  47. The Role of Nontraditional Glycemic Markers in Diabetes and Albuminuria
    April P Carson; Fiscal Year: 2013
    ..incident diabetes;2) to evaluate the association of GA, fructosamine, and 1,5-AG with prevalent and incident albuminuria;and 3) to evaluate racial differences in the association of GA, fructosamine, and 1,5-AG with diabetes and ..
  48. REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-2
    Monika M Safford; Fiscal Year: 2013
    ..g., cholesterol, albuminuria, CRP) and ECGs...
  49. Generating Mouse Mutants with Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2010
    ..not ApoE or LDLR was associated with a marked acceleration of DN in C57BL/6, not only characterized by a robust albuminuria, but also by dramatic mesangiolysis and expansion with decrease renal function (GFR)...
  50. Mechanisms of Renal Lipid Accumulation in Diabetic Nephropathy
    Lisa R Tannock; Fiscal Year: 2013
    ..Despite best current treatments, significant numbers of individuals with albuminuria progress to end stage renal disease...
  51. Podocyte Microenvironment in Diabetic Nephropathy
    Alaa S Awad; Fiscal Year: 2011
    ..podocyte niche (microenvironment) are likely responsible for abnormal podocyte function leading to progressive albuminuria and progressive renal failure. Podocj^e function is intimately linked to its complex cytoskeletal structure...
  52. Health IT Enhanced for CKD in Safety-Net Primary Care
    Neil R Powe; Fiscal Year: 2013
    ..the Enhanced CKD Registry. We will also examine secondary clinical (e.g., albuminuria, HbA1c), intermediate (e.g., awareness, activation, ACE/ARB use), and sustainability (e.g...
  53. Natural History of Microalbuminuria in Type 1 Diabetes
    Andrzej S Krolewski; Fiscal Year: 2013
    ..of Microalbuminuria (MA) in type 1 diabetes we found that in the majority of patients MA regresses to normo-albuminuria, However, in a third of patients with MA significant renal function decline occurs;this decline is progressive ..
  54. Podocyte Secreted Proteins
    SUMANT SINGH CHUGH; Fiscal Year: 2013
    ..with transgenic expression of Angptl4 from podocytes over a period of 12 day results in over 40% reduction in albuminuria, and significantly increases sialylation of Angptl4...
  55. Adiponectin and Podocytes
    Kumar Sharma; Fiscal Year: 2013
    ..Summary/Abstract We have recently identified that circulating adiponectin levels negatively correlate with albuminuria in obese African Americans...
  56. Pathophysiological role of prorenin in CKD
    Alfred K Cheung; Fiscal Year: 2013
    ..a correlation between serum prorenin/renin levels with the development of microvascular diseases, including albuminuria and retinopathy, in patients with diabetes...
  57. Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial
    Andrew S Levey; Fiscal Year: 2011
    ..studies under review will further address the interrelationships between initial renal function and degree of albuminuria, and/or serial changes in these parameters, with both renal and CVD outcomes in the FAVORIT cohort...
  58. Hypertensive Renal Injury
    Peter A Doris; Fiscal Year: 2013
    ..This variation associates with increased albuminuria. We propose to investigate whether alterations in immune function that are encoded by differences in the heavy ..
  59. EPIDEMIC HYPERTENSION IN NIGERIAN WORKERS
    Clareann Bunker; Fiscal Year: 1999
    ..recalls, alcohol intake, menopausal status, psychosocial measures, 24 hour urine for Na, K, creatinine, micro-albuminuria, and fasting serum for lipids, insulin, glucose, and creatinine...
  60. Hypertensive Renal Injury
    Peter A Doris; Fiscal Year: 2012
    ..This variation associates with increased albuminuria. We propose to investigate whether alterations in immune function that are encoded by differences in the heavy ..
  61. PATHOGENIC ROLE OF THE COMPLEMENT SYSTEM IN MURINE LUPUS
    Richard Quigg; Fiscal Year: 2009
    ..In addition to examining renal phenotype through the measurement of albuminuria and glomerular filtration, additional complement dependent phenotypic changes that will be studied include ..
  62. Angiogenic Signals in Diabetic Complications
    Thomas M Coffman; Fiscal Year: 2010
    ..3. To define the consequences of altered angiogenic signaling on the development of albuminuria and nephropathy in diabetes.
  63. Effects of the DASH Diet in Albuminuria
    David Jacobs; Fiscal Year: 2003
    Clinical grade albuminuria and microalbuminuria are associated with high risk of chronic renal insufficiency, cardiovascular disease and death...
  64. PATHOPHYSIOLOGY OF AIDS GLOMERULOPATHY
    Bryan Myers; Fiscal Year: 1992
    ..of 500 AIDS patients with a sensitive immunochemical technique for subclinical as well as overt elevation of albuminuria. Twenty-five AIDS patients with heavy proteinuria will then be examined with physiologic, morphometric and cell ..
  65. Pathobiology of HMG-CoA reductase inhibitors in diabetes
    Yashpal Kanwar; Fiscal Year: 2006
    ..whether the renoprotective effect of simvastatin will translate into a significant improvement in reducing albuminuria in vivo, studies are proposed using NOD mice and streptozotocin-induced diabetic rats, established models of ..
  66. PATHOBIOLOGY OF GLOMERULAR INJURY IN TYPE II DIABETES
    Timothy Meyer; Fiscal Year: 1993
    ..of type II diabetes (Group 3), GFR becomes still more elevated, and falls back to the normal range only after albuminuria has increased to above 300 mu(g)/min following several more years of type II diabetes (Group 4)...
  67. Angiotensin II, TGF-beta, and the podocyte in diabetes
    Sheldon Chen; Fiscal Year: 2009
    ..of diabetic glomerulopathy, as reflected by altered GBM composition, decreased podocyte number, and albuminuria. The mechanisms of these changes are incompletely understood, but up-regulation of Vascular Endothelial Growth ..
  68. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR EXPRESSION
    NICOLAS GUZMAN; Fiscal Year: 2001
    ..In these patients, thiazolidinediones reduce albuminuria by mechanisms independent of their glucose-lowering action...
  69. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    ..hyperintensities, brain atrophy, and ventricular volume) and chronic kidney disease (serum creatinine and albuminuria) have been collected...
  70. Role of TRP Channels in Statin Reversal of Nephropathy in Early Stage Type 2 DM
    STEVEN SANSOM; Fiscal Year: 2009
    ..mesangial proliferation, collagen IV deposition, basement membrane thickening, glomerular hypertrophy, and albuminuria in the early stages of type 2 DM...