proteinuria

Summary

Summary: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.

Top Publications

  1. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
  2. ncbi Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
  3. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
  4. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  5. ncbi Proteinuria: detection and role in native renal disease progression
    Jose Luis Gorriz
    Servicio de Nefrologia, Hospital Universitario Dr Peset, Valencia, Spain
    Transplant Rev (Orlando) 26:3-13. 2012
  6. ncbi Proteinuria and clinical outcomes after ischemic stroke
    Y Kumai
    Cerebrovascular and Neurology Center, National Hospital Organization Fukuoka Higashi Medical Center, Fukuoka, Japan
    Neurology 78:1909-15. 2012
  7. ncbi Properties of the glomerular barrier and mechanisms of proteinuria
    Borje Haraldsson
    Department of Molecular and Clinical Medicine Nephrology, Institute of Medicine, Goteborg University, Sweden
    Physiol Rev 88:451-87. 2008
  8. ncbi Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 42:617-22. 2003
  9. pmc Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation
    David G Warnock
    University of Alabama at Birmingham, Birmingham, AL, USA
    Nephrol Dial Transplant 27:1042-9. 2012
  10. ncbi Proteinuria and events beyond the slit
    Rikke Nielsen
    Department of Anatomy, Section of Cell Biology, Aarhus University, Building 1234, Aarhus C, Denmark
    Pediatr Nephrol 25:813-22. 2010

Detail Information

Publications399 found, 100 shown here

  1. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
    ..or factors that cause maternal endothelial dysfunction, resulting in the clinical findings of hypertension, proteinuria, and edema...
  2. ncbi Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    ..Although proteinuria is also associated with adverse outcomes, it is not used to refine risk estimates of adverse events in this ..
  3. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
    ..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
  4. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  5. ncbi Proteinuria: detection and role in native renal disease progression
    Jose Luis Gorriz
    Servicio de Nefrologia, Hospital Universitario Dr Peset, Valencia, Spain
    Transplant Rev (Orlando) 26:3-13. 2012
    The presence of albuminuria or proteinuria constitutes a sign of kidney damage and, together with the estimation of glomerular filtration rate, is based on the evaluation of chronic kidney disease...
  6. ncbi Proteinuria and clinical outcomes after ischemic stroke
    Y Kumai
    Cerebrovascular and Neurology Center, National Hospital Organization Fukuoka Higashi Medical Center, Fukuoka, Japan
    Neurology 78:1909-15. 2012
    ..The aim of the present study was to elucidate how CKD and its components, proteinuria and low estimated glomerular filtration rate (eGFR), affect the clinical outcomes after ischemic stroke.
  7. ncbi Properties of the glomerular barrier and mechanisms of proteinuria
    Borje Haraldsson
    Department of Molecular and Clinical Medicine Nephrology, Institute of Medicine, Goteborg University, Sweden
    Physiol Rev 88:451-87. 2008
    ..However, since all components of the glomerular membrane are important for its function, proteinuria will occur regardless of which layer is affected by disease...
  8. ncbi Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 42:617-22. 2003
  9. pmc Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation
    David G Warnock
    University of Alabama at Birmingham, Birmingham, AL, USA
    Nephrol Dial Transplant 27:1042-9. 2012
    ..The purpose of this study was to identify determinants of renal disease progression in adults with Fabry disease during treatment with agalsidase beta...
  10. ncbi Proteinuria and events beyond the slit
    Rikke Nielsen
    Department of Anatomy, Section of Cell Biology, Aarhus University, Building 1234, Aarhus C, Denmark
    Pediatr Nephrol 25:813-22. 2010
    The origin of proteinuria is found in either the glomerular filtration device or the proximal tubular reabsorption machinery...
  11. pmc Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling
    Karen Sison
    The Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    J Am Soc Nephrol 21:1691-701. 2010
    ..VEGF produced by the podocyte regulates the structure and function of the adjacent endothelial cell...
  12. pmc Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN
    D B Donoviel
    Pharmaceutical Biology, Lexicon Genetics, Inc, The Woodlands, Texas 77381, USA
    Mol Cell Biol 21:4829-36. 2001
    ..b>Proteinuria ranging from 300 to 2,000 mg/dl was present in all Neph1(-/-) mice...
  13. ncbi Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    b>Proteinuria or albuminuria is an established risk marker for progressive renal function loss. Albuminuria can be effectively lowered with antihypertensive drugs that interrupt the renin-angiotensin system (RAS)...
  14. ncbi The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death
    H Putaala
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Hum Mol Genet 10:1-8. 2001
    ..Although seemingly normal at birth, they immediately developed massive proteinuria and edema and died within 24 h...
  15. ncbi Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease...
  16. pmc Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function
    James P Lash
    University of Illinois at Chicago, Department of Medicine Section of Nephrology MC 793, 820 South Wood Street, Chicago, IL 60612 7315, USA
    Clin J Am Soc Nephrol 4:1302-11. 2009
    ..We examined baseline demographic and clinical characteristics...
  17. ncbi Remission of proteinuria improves prognosis in IgA nephropathy
    Heather N Reich
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Nephrol 18:3177-83. 2007
    b>Proteinuria has been shown to be an adverse prognostic factor in IgA nephropathy. The benefit of achieving a partial remission of proteinuria, however, has not been well described...
  18. pmc Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria
    Young Sun Kang
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 78:363-73. 2010
    b>Proteinuria is a primary clinical symptom of a large number of glomerular diseases that progress to end-stage renal failure...
  19. ncbi The podocyte's response to injury: role in proteinuria and glomerulosclerosis
    S J Shankland
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 69:2131-47. 2006
    ..They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases...
  20. ncbi Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions
    Mehmet Kanbay
    35 Sokak, 81 5, Bahcelievler, Ankara, 06490, Turkey
    Int Urol Nephrol 39:1227-33. 2007
    ..However, there is no data about the effect of lowering uric acid level on hypertension, renal function, and proteinuria in patients with glomerular filtration rate (GFR) >60 ml/min...
  21. ncbi Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial
    Jackson T Wright
    Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
    JAMA 288:2421-31. 2002
    ..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
  22. pmc Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria
    Yingjian Li
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Pathol 172:299-308. 2008
    Podocyte dysfunction plays an essential role in the pathogenesis of proteinuria and glomerulosclerosis. However, the mechanism underlying podocyte dysfunction in many common forms of chronic kidney diseases remains poorly understood...
  23. ncbi How does proteinuria cause progressive renal damage?
    Mauro Abbate
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    J Am Soc Nephrol 17:2974-84. 2006
    The possibility that proteinuria may accelerate kidney disease progression to end-stage renal failure has received support from the results of increasing numbers of experimental and clinical studies...
  24. pmc Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier
    George Jarad
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 116:2272-9. 2006
    Primary defects in either podocytes or the glomerular basement membrane (GBM) cause proteinuria, a fact that complicates defining the barrier to albumin...
  25. pmc Valproic acid attenuates proteinuria and kidney injury
    Katrien Van Beneden
    Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels, Belgium
    J Am Soc Nephrol 22:1863-75. 2011
    ..Administration of valproic acid before kidney injury prevented the development of proteinuria and the onset of glomerulosclerosis...
  26. ncbi Coronary artery calcification and mortality in diabetic patients with proteinuria
    Yi Wen Chiu
    Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, California, USA
    Kidney Int 77:1107-14. 2010
    ..Additional studies need to determine whether altering the natural history of coronary artery calcification in early chronic kidney disease prolongs survival...
  27. ncbi The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study
    William F Keane
    Department of Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Kidney Int 63:1499-507. 2003
    ..We examined the risk factors that predict loss of kidney function (doubling of serum creatinine) or ESRD (dialysis or transplantation) in patients with type 2 diabetes in whom blood pressure was controlled...
  28. ncbi Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States
    Paul Muntner
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
    J Am Soc Nephrol 13:745-53. 2002
    ..This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates...
  29. pmc Risk factors for end-stage renal disease: 25-year follow-up
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    Arch Intern Med 169:342-50. 2009
    ..Few cohort studies have focused on risk factors for end-stage renal disease (ESRD). This investigation evaluated the prognostic value of several potential novel risk factors for ESRD after considering established risk factors...
  30. pmc Inhibition of podocyte FAK protects against proteinuria and foot process effacement
    Hong Ma
    Departments of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Soc Nephrol 21:1145-56. 2010
    ..To understand better the mechanisms by which podocyte foot process effacement leads to proteinuria and kidney failure, we studied the function of FAK in podocytes...
  31. ncbi Proteinuria and the risk of developing end-stage renal disease
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of The Ryukyus and Okinawa General Health Maintenance Association, Okinawa, Japan
    Kidney Int 63:1468-74. 2003
    Dipstick urinalysis for proteinuria and hematuria has been used to screen renal disease, but evidence of the clinical impact of this test on development of end-stage renal disease (ESRD) is lacking.
  32. ncbi Corticosteroid effectiveness in IgA nephropathy: long-term results of a randomized, controlled trial
    Claudio Pozzi
    Department of Nephrology and Dialysis, A Manzoni Hospital, Lecco, Italy
    J Am Soc Nephrol 15:157-63. 2004
    b>Proteinuria plays a causal role in the progression of IgA nephropathy (IgAN). A previous controlled trial showed that steroids are effective in reducing proteinuria and preserving renal function in patients with IgAN...
  33. ncbi Microalbuminuria in the US population: third National Health and Nutrition Examination Survey
    Camille A Jones
    Division of Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA, 02215, USA
    Am J Kidney Dis 39:445-59. 2002
    ..The percent prevalence of clinical proteinuria (UAC > or = 300 mg/L) was similar for males and females...
  34. ncbi Antiproteinuric effect of oral paricalcitol in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Kidney Int 68:2823-8. 2005
    b>Proteinuria is a marker of cardiovascular and renal disease in patients with chronic kidney disease (CKD), and reduction in proteinuria has been associated with improved cardiovascular and renal outcomes...
  35. ncbi Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis
    Xiaolei Zhu
    Division of Nephrology, SUNY at Stony Brook, NY, USA
    Am J Kidney Dis 49:186-93. 2007
    ..The overall risk of proteinuria and hypertension in patients with cancer on bevacizumab therapy is unclear...
  36. ncbi Weight loss and proteinuria: systematic review of clinical trials and comparative cohorts
    Farsad Afshinnia
    St Joseph s Hospital, HealthEast Care System, University of Minnesota School of Public Health, Minneapolis, MN, USA
    Nephrol Dial Transplant 25:1173-83. 2010
    Obesity is a risk factor for the progression of chronic kidney disease (CKD). The impact of weight loss on proteinuria and renal function is less clear...
  37. ncbi Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK
    Shigetaka Yoshida
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 108:e57-68. 2008
    b>Proteinuria is a well-established exacerbating factor in chronic kidney disease...
  38. ncbi Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy
    Chia Chao Wu
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, Taiwan
    Clin Chim Acta 411:700-4. 2010
    ..However, the definite pathogenesis, especially the role of immune response, is still unclear...
  39. pmc Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy
    Natalia Polanco
    Hospital 12 de Octubre, Madrid, Spain
    J Am Soc Nephrol 21:697-704. 2010
    ..Spontaneous remission occurred in 104 (32%) patients: proteinuria progressively declined after diagnosis until remission of disease at 14.7 +/- 11.4 months...
  40. pmc Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis
    Shaolin Shi
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 19:2159-69. 2008
    ..Mutant mice developed proteinuria 4 to 5 weeks after birth and died several weeks later, presumably from kidney failure...
  41. ncbi Proteinuria should be used as a surrogate in CKD
    Paolo Cravedi
    Mario Negri Institute of Pharmacological Research, Azienda Ospedaliera Ospedali Riuniti di Bergamo, via Stezzano 87, 24126 Bergamo, Italy
    Nat Rev Nephrol 8:301-6. 2012
    ..The magnitude of proteinuria is widely recognized as a marker of the severity of glomerulopathy...
  42. pmc Cubilin is essential for albumin reabsorption in the renal proximal tubule
    Sabine Amsellem
    INSERM UMR S968, Institut de la Vision, 17 rue Moreau, 75012 Paris, France
    J Am Soc Nephrol 21:1859-67. 2010
    ..These genetic models will allow further analysis of protein trafficking in the progression of proteinuric renal diseases...
  43. pmc Relationships of risk factors for pre-eclampsia with patterns of occurrence of isolated gestational proteinuria during normal term pregnancy
    Corrie Macdonald-Wallis
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e22115. 2011
    Isolated gestational proteinuria may be part of the pre-eclampsia disease spectrum...
  44. pmc Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting
    Tao Min Huang
    Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Zhong Zheng District, Taipei 100, Taiwan
    J Am Soc Nephrol 22:156-63. 2011
    Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown...
  45. ncbi Oral calcitriol for reduction of proteinuria in patients with IgA nephropathy: a randomized controlled trial
    Li Jun Liu
    Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, PR China
    Am J Kidney Dis 59:67-74. 2012
    Vitamin D has shown efficacy in the reduction of proteinuria in patients with chronic kidney disease. This study aimed to determine the effect of calcitriol on urinary protein excretion in patients with immunoglobulin A (IgA) nephropathy.
  46. ncbi Proteinuria as a surrogate outcome in CKD: report of a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration
    Andrew S Levey
    Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 54:205-26. 2009
    Changes in proteinuria have been suggested as a surrogate outcome for kidney disease progression to facilitate the conduct of clinical trials...
  47. ncbi Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy
    Fuad N Ziyadeh
    Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Curr Diabetes Rev 4:39-45. 2008
    ..all comprise the principal features of diabetic podocytopathy that clinically manifests as albuminuria and proteinuria. Many of these events are mediated by angiotensin II whose local concentration is stimulated by high glucose, ..
  48. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011
    ..Here, we report that Am580, a water-soluble RARα-specific agonist, attenuated proteinuria, glomerosclerosis, and podocyte proliferation, and restored podocyte differentiation markers in kidneys of Tg26 ..
  49. ncbi Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin A nephropathy: an uncontrolled trial
    Cheuk Chun Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Am J Kidney Dis 51:724-31. 2008
    ..We conducted an open-label study to evaluate the antiproteinuric effect of calcitriol on proteinuria in patients with immunoglobulin A (IgA) nephropathy.
  50. ncbi Inter-individual differences in anti-proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage
    Andrea B Kramer
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    J Pathol 201:160-7. 2003
    ACE inhibition (ACEi) reduces proteinuria and provides reno-protection, but not all subjects benefit from ACEi...
  51. ncbi Efficacy and safety of paricalcitol therapy for chronic kidney disease: a meta-analysis
    Jun Cheng
    Kidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China
    Clin J Am Soc Nephrol 7:391-400. 2012
    ..newer vitamin D compounds such as paricalcitol can suppress serum intact parathyroid hormone (iPTH) and reduce proteinuria in patients with CKD...
  52. ncbi Clinico-pathological correlations in 127 patients in 11 large pedigrees, segregating one of three heterozygous mutations in the COL4A3/ COL4A4 genes associated with familial haematuria and significant late progression to proteinuria and chronic kidney dis
    Alkis Pierides
    Department of Nephrology, Nicosia General Hospital, University of Cyprus, Cyprus
    Nephrol Dial Transplant 24:2721-9. 2009
    ..Heterozygous mutations in the COL4A3/ COL4A4 genes are currently thought to be responsible for familial benign microscopic haematuria and maintenance of normal long-term kidney function...
  53. ncbi Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats
    Jane L Finch
    Renal Div, Box 8126, Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Renal Physiol 302:F141-9. 2012
    ..8 μg/kg ip, 3 × wk), or U+enalapril+paricalcitol (UEP). Despite hypertension in UP rats, proteinuria decreased by 32% vs. UC rats...
  54. ncbi Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass
    Fritz Diekmann
    Department of Nephrology and Renal Transplantation, Hospital Clinic, Villarroel, 170, E 08036 Barcelona, Spain
    J Am Soc Nephrol 18:2653-60. 2007
    Many kidney transplant patients experience an increase in proteinuria when converted from a calcineurin inhibitor-based regimen to one based on a mammalian target of rapamycin (mTOR) inhibitor, and preexisting proteinuria and poor renal ..
  55. ncbi Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats
    Shintaro Nakamaki
    Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Fukushima City, Japan
    Exp Biol Med (Maywood) 236:614-20. 2011
    ..The degree of proteinuria was significantly reduced in Ad-Adipo rats compared with Ad-lacZ rats...
  56. ncbi Effect of lipid reduction on the progression of renal disease: a meta-analysis
    L F Fried
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 59:260-9. 2001
    ..We examined the effects of antilipemic agents on glomerular filtration rate and proteinuria or albuminuria in patients with renal disease.
  57. ncbi Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy
    Margo P Cohen
    University City Science Center, Institute of Metalboic Research, Philadelphia, Pennsylania 19104, USA
    Kidney Int 68:1554-61. 2005
    ....
  58. ncbi Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise
    Chirag R Parikh
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, CT, USA
    Ann Clin Biochem 47:301-12. 2010
    ..Future studies will need to address these limitations in order for further progress to be made...
  59. doi A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib
    Tejas V Patel
    J Natl Cancer Inst 100:282-4. 2008
  60. ncbi Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events
    Y Wang
    Department of Renal Medicine, University of Sydney at Westmead Hospital, Westmead, Australia
    Kidney Int 58:1797-804. 2000
    ..Herein, we describe a stable and reproducible murine model of chronic proteinuria induced by ADR.
  61. ncbi Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study
    Marcello Tonelli
    University of Alberta, Edmonton, Canada
    Ann Intern Med 154:12-21. 2011
    The staging system for chronic kidney disease relies almost exclusively on estimated glomerular filtration rate (eGFR), although proteinuria is also associated with adverse outcomes.
  62. pmc Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury
    Weichun He
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 22:90-103. 2011
    ..in other tissues, we tested whether the vitamin D analog paricalcitol could ameliorate podocyte injury, proteinuria, and renal fibrosis in adriamycin (ADR) nephropathy...
  63. ncbi The natural history of immunoglobulin a nephropathy among patients with hematuria and minimal proteinuria
    C C Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Am J Med 110:434-7. 2001
    ..natural history of immunoglobulin (Ig) A nephropathy among patients who presented with hematuria and minimal proteinuria, and factors associated with the development of adverse clinical events, such as proteinuria...
  64. ncbi Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    Regina Kunz
    Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Ann Intern Med 148:30-48. 2008
    Reduction of proteinuria is associated with delayed progression of chronic kidney disease. Reports suggest that angiotensin-receptor blockers (ARBs) reduce proteinuria, but results are variable...
  65. ncbi Proteinuria in diabetic kidney disease: a mechanistic viewpoint
    J A Jefferson
    Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Kidney Int 74:22-36. 2008
    b>Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk factor for both renal disease progression, and cardiovascular disease...
  66. ncbi Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial
    D C Cattran
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 59:1484-90. 2001
    ..Cyclosporine has been shown to be effective in cases of progressive MGN, but it has not been used in controlled studies at an early stage of the disease...
  67. pmc Urine proteomics: the present and future of measuring urinary protein components in disease
    Jonathan Barratt
    Department of Infection, Immunity and Inflammation, John Walls Renal Unit, Leicester General Hospital, Leicester, UK
    CMAJ 177:361-8. 2007
    ..Today, urinalysis, in particular the measurement of proteinuria, underpins the routine assessment of patients with renal disease...
  68. ncbi A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa
    T M Han
    Department of Nephrology, Division of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Kidney Int 69:2243-50. 2006
    ..In this single-center cross-sectional study, 615 HIV-infected patients were screened for proteinuria. Thirty patients with varying degrees of proteinuria underwent renal biopsy...
  69. pmc Melanocortin 1 receptor agonists reduce proteinuria
    Annika Lindskog
    Department of Molecular and Clinical Nephrology, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Am Soc Nephrol 21:1290-8. 2010
    ..Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown...
  70. pmc Proteinuria: an enzymatic disease of the podocyte?
    Peter Mundel
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 77:571-80. 2010
    b>Proteinuria is a major health-care problem that affects several hundred million people worldwide...
  71. ncbi Model of robust induction of glomerulosclerosis in mice: importance of genetic background
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 64:350-5. 2003
    ..A pole resection protocol, applied in 129/Sv mice, induced only mild glomerulosclerosis. We present here a highly reproducible, modified RKM approach to successfully establish a glomerulosclerosis model in mice...
  72. ncbi Vitamin D, proteinuria, diabetic nephropathy, and progression of CKD
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 4:1523-8. 2009
    ..Emerging evidence in patients with chronic kidney disease (CKD) show that vitamin D can reduce proteinuria or albuminuria even in the presence of angiotensin-converting enzyme inhibition...
  73. ncbi The mTOR inhibitor everolimus induces proteinuria and renal deterioration in the remnant kidney model in the rat
    Regina Vogelbacher
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
    Transplantation 84:1492-9. 2007
    ..immunosuppressive mammalian target of rapamycin (mTOR) inhibitors can cause renal deterioration and proteinuria after conversion from calcineurin inhibitors, especially in long-term renal transplant patients with low ..
  74. pmc Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes
    Etsuko Yanagida-Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Pathol 171:415-27. 2007
    The actin-based foot processes of kidney podocytes and the interposed slit diaphragm form the final barrier to proteinuria. Mutations affecting several podocyte proteins cause disruption of the filtration barrier and rearrangement of the ..
  75. ncbi Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes
    David Ray
    Centre for Molecular Medicine, University of Manchester, Manchester, U K
    Diabetes 53:861-4. 2004
    ..Increased VEGF production from high-expressing haplotypes, including -460C, may promote neovascularization...
  76. pmc Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
    Giuseppe Remuzzi
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    J Clin Invest 116:288-96. 2006
    ..While genetic factors contribute to susceptibility and progression of renal disease, proteinuria has been claimed as an independent predictor of outcome...
  77. ncbi Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome
    Masao Koshikawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Am Soc Nephrol 16:2690-701. 2005
    ..play an important role in maintaining normal glomerular function and structure, and podocyte injury leads to proteinuria and glomerulosclerosis...
  78. ncbi Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Jena, Germany
    Nephron Physiol 106:p26-31. 2007
    ..clinically detectable abnormalities in diabetic nephropathy is microalbuminuria that eventually progresses to proteinuria. The degree of proteinuria correlates with the progression of glomerulosclerosis and tubulointerstitial ..
  79. pmc Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 19:999-1007. 2008
    ..A low-sodium diet or addition of diuretics enhances the effects of RAAS blockade on proteinuria and BP, but the efficacy of the combination of these interventions is unknown...
  80. ncbi Key predictive factors of axitinib (AG-013736)-induced proteinuria and efficacy: a phase II study in Japanese patients with cytokine-refractory metastatic renal cell Carcinoma
    Yoshihiko Tomita
    Department of Urology, Yamagata University Faculty of Medicine, Yamagata, Japan
    Eur J Cancer 47:2592-602. 2011
    ..This phase II study investigated axitinib efficacy, safety and biomarkers in Japanese patients with cytokine-refractory metastatic renal cell carcinoma (mRCC)...
  81. ncbi Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes
    Zhuowei Wang
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 54:2328-35. 2005
    ..glomerulosclerosis, tubulointerstitial fibrosis, increased expression of type IV collagen and fibronectin, and proteinuria, which is associated with increased renal mRNA abundance of transforming growth factor-beta, plasminogen ..
  82. pmc The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease
    Jan Skupien
    Research and Clinic Divisions, Joslin Diabetes Center, Boston, MA, USA
    Kidney Int 82:589-97. 2012
    The risk of end-stage renal disease (ESRD) remains high in patients with type 1 diabetes and proteinuria; however, little is known about the rate of decline in their renal function...
  83. pmc Hemodynamic correlates of proteinuria in chronic kidney disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine Medical Center, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 6:2403-10. 2011
    Brachial artery measures of BP are associated with increasing degrees of proteinuria. Whether central measures of BP or vascular stiffness are associated with increased risk of proteinuria in patients with chronic kidney disease (CKD) is ..
  84. pmc Inducible podocyte injury and proteinuria in transgenic zebrafish
    Weibin Zhou
    University of Michigan Medical School, 8240 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5646, USA
    J Am Soc Nephrol 23:1039-47. 2012
    ..zebrafish expressing green fluorescent protein (GFP)-tagged vitamin D-binding protein (VDBP) as a tracer for proteinuria. In the VDBP-GFP and pod::NTR-mCherry double-transgenic fish, induction of podocyte damage led to whole-body ..
  85. ncbi Influence of smoking and obesity on the development of proteinuria
    Masahiko Tozawa
    Third Department of Internal Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Kidney Int 62:956-62. 2002
    b>Proteinuria is a significant risk factor for end-stage renal disease. Previous evidence suggested that smoking and obesity increase the risk of proteinuria...
  86. ncbi Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria
    Donghai Yu
    Department of Medicine, Division of Nephrology and Clinical Immunology, University of Aachen, Germany
    J Am Soc Nephrol 16:1733-41. 2005
    ..1 nephritis) in parallel to the onset of proteinuria. However, subsequently proteinuria persisted despite remission of podocyturia...
  87. ncbi Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat
    John W Newman
    Western Human Nutrition Research Center, United States Department of Agriculture, USA
    J Lipid Res 48:1792-800. 2007
    We previously established that proteinuria alters the apolipoprotein content of lipoproteins...
  88. pmc The threshold level of urinary cadmium associated with increased urinary excretion of retinol-binding protein and beta 2-microglobulin: a re-assessment in a large cohort of nickel-cadmium battery workers
    Agnès Chaumont
    Unit of Toxicology and Applied Pharmacology, Catholic University of Louvain, Avenue E Mounier 53 02, Brussels B 1200, Belgium
    Occup Environ Med 68:257-64. 2011
    ..On the basis of associations undistorted by smoking and adjusted for covariates, the BMDL5 of CdU for low-molecular-weight proteinuria induced by occupational exposure to Cd can be reliably estimated between 5.5 and 6.6 μg/g creatinine.
  89. ncbi Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
    Kalani L Raphael
    VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 79:356-62. 2011
    ..Mean baseline serum bicarbonate, measured GFR, and proteinuria were 25.1 mmol/l, 46 ml/min per 1.73 m(2), and 326 mg/g of creatinine, respectively...
  90. ncbi Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases
    Shunichi Kojima
    Division of Internal Medicine, National Hospital Organization Shizuoka Medical Center, Japan
    Hypertens Res 27:379-85. 2004
    ..This study compared cilnidipine and amlodipine with respect to their effects on renal function and proteinuria. Twenty-eight proteinuric hypertensive outpatients (13 men and 15 women, aged 62+/-2 years) who had been ..
  91. ncbi Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease
    T H Jafar
    Division of Nephrology, New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 60:1131-40. 2001
    ..effect of ACE inhibitors on the progression of renal disease in patients with higher baseline levels of proteinuria is due to their greater antiproteinuric effect in these patients...
  92. pmc Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome?--a prospective cohort study
    Farhad F Vasanwala
    Department of Family Medicine and Continuing Care, Singapore General Hospital, Bowyer Block A, Level 2, 169608, Singapore
    BMC Infect Dis 11:212. 2011
    ..We explored whether proteinuria could be used as such a marker.
  93. ncbi Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro
    Zhao Hong Chen
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Kidney Int 77:974-88. 2010
    ..a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-..
  94. ncbi Urine excretion of protein HC in proteinuric glomerular diseases correlates to urine IgG but not to albuminuria
    O Bakoush
    Department of Nephrology, Lund University Hospital, Klinikgatan 18, S 221 85 Lund, Sweden
    Kidney Int 60:1904-9. 2001
    ..Patients with nonselective proteinuria, that is, increased urine excretion of high-molecular-weight plasma proteins such as IgG in comparison to ..
  95. ncbi Tubular changes in early diabetic nephropathy
    M C Thomas
    Danielle Alberti Memorial Centre for Diabetes Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Adv Chronic Kidney Dis 12:177-86. 2005
    ..ion transport, and other tubular changes reviewed in this paper, are already apparent before the onset of proteinuria in diabetes...
  96. ncbi Significance and management of proteinuria in kidney transplant recipients
    Hatem Amer
    Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 20:2490-2. 2009
    b>Proteinuria is common after kidney transplantation and typically urine protein levels are below 500 mg/d. However, even these low levels are associated with reduced graft survival...
  97. ncbi Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy
    Ramon G B Bonegio
    Evans Biomedical Research Center, Room X530, Boston University Medical Center, 650 Albany Street, Boston, MA 02129, USA
    J Am Soc Nephrol 16:2063-72. 2005
    b>Proteinuria is a risk factor for progression of chronic renal failure. A model of proteinuria-associated tubulointerstitial injury was developed and was used to examine the therapeutic effect of rapamycin. Two studies were performed...
  98. ncbi Beneficial effect of Bupleurum polysaccharides on autoimmune disease induced by Campylobacter jejuni in BALB/c mice
    Zheng Wang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China
    J Ethnopharmacol 124:481-7. 2009
    ..This study was to determine whether the crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium, had beneficial effects on autoimmune disease...
  99. pmc Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria
    Cary Stelloh
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Transl Res 159:80-9. 2012
    ....
  100. ncbi Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study
    Sydney C W Tang
    Nephrology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Nephrol Dial Transplant 27:613-8. 2012
    ..Its potential efficacy in nondiabetic chronic kidney diseases that are driven by renin-angiotensin system activation remains to be explored...
  101. ncbi Renal protection with angiotensin receptor blockers: where do we stand
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    J Nephrol 24:569-80. 2011
    ..Few within-class comparative studies exist. Telmisartan provides superior reductions in proteinuria to losartan, however, even when blood pressures are equalized with concomitant antihypertensives...

Research Grants71

  1. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..Intravenous injection of this fraction causes proteinuria in rats...
  2. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..We propose that combined oral supplementation of NAC and MTh flavonolignans will reduce proteinuria and urinary and systemic manifestations of oxidative stress and inflammation, which are characteristically ..
  3. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ..antibody or a soluble VEGF receptor antagonist, sFlt1, in rats and mice lead to the development of severe proteinuria and hypertension accompanied by glomerular endotheliosis...
  4. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..Physiological studies will be performed to assess GFR, blood pressure, and proteinuria, Western blot, immunofluorescence, genomic analysis will be used to evaluate the complex signaling pathways ..
  5. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..by applicant): Preeclampsia (PE) is a serious complication of pregnancy manifested by high blood pressure, proteinuria, and edema, sometimes with encephalopathy, seizures, and hepatic failure...
  6. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..We propose that combined oral supplementation of NAC and MTh flavonolignans will reduce proteinuria and urinary and systemic manifestations of oxidative stress and inflammation, which are characteristically ..
  7. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..The renal tubular abnormalities of LOCR, particularly low molecular weight (LMW) proteinuria and aminoaciduria, overlap with those of Dent disease, a disorder that affects only the kidney...
  8. Role of Endocytosis and Vesicular Trafficking in Podocyte Health and Filter Integ
    Puneet Garg; Fiscal Year: 2012
    ..Glomerular diseases including diabetic nephropathy present with protein leak (proteinuria) in the urine...
  9. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in CKD patients and also provide survival benefits for CKD patients...
  10. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in diabetic nephropathy patients and also provide cardiovascular and survival benefits for CKD ..
  11. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..It is characterized by maternal hypertension, edema, and proteinuria, conditions that in the more serious, early onset disease can manifest as soon as 20 weeks of pregnancy...
  12. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    ..of sex chromosome complement on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  13. Transcriptional regulation of proteinuria
    SUMANT SINGH CHUGH; Fiscal Year: 2011
    ..Our long term goal is to define the precise mechanisms of proteinuria and glomerular disease, so as to develop new treatments in the future...
  14. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ..by applicant): Preeclampsia is a major complication of pregnancy characterized by hypertension (HTN) and proteinuria;however, the underlying mechanisms are unclear...
  15. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    ..In both strains, the female ER[unreadable] KOs developed significantly less proteinuria and pathologic renal disease and had significantly prolonged survival, despite increased serum levels of ..
  16. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..Preeclampsia (PE) is a dangerous complication of pregnancy characterized by sudden onset hypertension, proteinuria, inflammation, and coagulopathy...
  17. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..In addition, the maternal RAS becomes dysregulated in PE which is characterized by maternal hypertension and proteinuria. We have recently discovered that the Brown Norway (BN) rat model of placental insufficiency present ..
  18. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ..Nephrotic syndrome (NS) is a kidney disease characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, due to the disruption of renal glomerular filtration barrier (GFB) ..
  19. Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
    Sarosh Rana; Fiscal Year: 2013
    ..PE is characterized by new onset hypertension and proteinuria occurring after 20 weeks of gestation. Currently, the only treatment for PE is delivery...
  20. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..syndrome is a major cause of kidney failure, and patients with this condition develop large amounts of proteinuria and elevated levels of plasma lipids (triglycerides and cholesterol)...
  21. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2013
    ..When podocytes are damaged, the cell body retracts resulting in effacement and subsequently, proteinuria. For effacement to occur, cells must regulate adhesive contacts between the glomerular basement membrane and ..
  22. Vitamin D Deficiency in Glomerular Disease
    Michelle Denburg; Fiscal Year: 2013
    ..challenges of managing vitamin D deficiency in patients with glomerular diseases complicated by nephrotic-range proteinuria. Vitamin D deficiency may be an important modifiable risk factor for renal disease progression and ..
  23. Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study
    Clifford E Kashtan; Fiscal Year: 2013
    ..to populate adequately-powered clinical trials focused on two clinical targets, microalbuminuria and overt proteinuria, and (2) to test the hypothesis that in males with Alport syndrome urinary uromodulin excretion decreases as ..
  24. The role of NFAT in podocyte damage and proteinuric kidney disease
    ALEXIS JOANNA SLOAN; Fiscal Year: 2013
    ..in the presence of calcium, and our group has demostrated that constitutive activation of calcineurin leads to proteinuria. However, to date calcineurins canonical downstream target, the transcription factor nuclear factor of ..
  25. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..supplementation on urine protein excretion in adults with diabetes and kidney disease defined by the presence proteinuria. Diabetes is the most common cause of end-stage-kidney disease in the United States...
  26. Chronic kidney disease in survivors of hematopoietic cell transplant
    Sangeeta Hingorani; Fiscal Year: 2012
    ..Specific aim 2 will identify risk factors for mortality in patients with proteinuria at day 100 post-transplant...
  27. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..that the sequence of events leading to diabetic nephropathy begins from microalbuminuria, progressing to overt proteinuria and eventual end-stage renal disease...
  28. Caspase 8: A Novel Suppressor of Dendritic Cell-Mediated Autoimmunity
    Carla M Cuda; Fiscal Year: 2013
    ..dsDNA-reactive autoantibodies, glomerulonephritis, immune complex deposition in the kidney, exacerbated proteinuria levels, heightened amounts of serum pro-inflammatory cytokines (IL-12, IL-1[unreadable], and IFN[unreadable]/[..
  29. The Role of Cyclooxygenase-2 in Podocyte Injury in Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2013
    ..COX-2) increases in models of progressive renal injury, and selective COX-2 inhibitors decrease proteinuria and retard progressive renal injury in models of renal ablation, diabetes and salt- sensitive hypertension...
  30. Novel Models of Diabetic Nephropathy
    Moshe Levi; Fiscal Year: 2010
    ..accumulation is associated with development of robust glomerulosclerosis, tubulointerstitial fibrosis, and proteinuria. We have also found that the Farnesoid X Receptor (FXR) is highly expressed in the kidney and the expression of ..
  31. Podocyte TRB in Diabetic Nephropathy
    ROBYN A CUNARD; Fiscal Year: 2012
    ..Diabetic kidney disease is associated with podocyte (glomerular epithelial cell) dysfunction, which results in proteinuria and eventually glomerulosclerosis...
  32. Use of small molecules that stabilize dynamin rings in podocytopathies
    Sanja Sever; Fiscal Year: 2013
    ..Most forms of proteinuria and nephrotic syndrome are characterized by transformation of podocyte FPs into a band of cytoplasm due to de- ..
  33. Novel ex-vivo Immunoadsorption Therapy to Treat Preeclampsia
    Woo Joo; Fiscal Year: 2013
    ..PE is characterized by the onset of hypertension and proteinuria and can lead to more serious complications, such as seizure (eclampsia) and HELLP syndrome associated with ..
  34. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2013
    ..Nephrotic syndrome (NS) is a kidney disease characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, due to the disruption of renal glomerular filtration barrier (GFB) ..
  35. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2012
    ..Preeclampsia, a vascular disorder of pregnancy, characterized by hypertension and proteinuria, complicates up to 8 per cent of all pregnancies, and it is a leading cause of maternal morbidity worldwide...
  36. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..the diabetic phenotype and secondary effects of diabetes as demonstrated by the development of hyperglycemia, proteinuria and a decreased parasympathetic inhibition of Isoproterenol-stimulated L-type Ca2+ currents, and that estrogen ..
  37. Role of Epithelial Chemokines in Kidney Injury-Molecule-1 Induced Renal Fibrosis
    Benjamin D Humphreys; Fiscal Year: 2010
    ..Older mice developed progressive inflammatory cell infiltration and progressive proteinuria, anemia, renal failure, interstitial fibrosis and death from renal failure by 19 weeks...
  38. Serine Protease Corin in Pregnancy-induced Hypertension
    Qingyu Wu; Fiscal Year: 2013
    ..The mice also had late gestational proteinuria, a phenotype reminiscent of preeclampsia in humans...
  39. Proteinuria causes progressive kidney disease by impairing autophagy
    Andrea Havasi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Proteinuria is associated with progressive chronic kidney disease...
  40. Cytokine based murine focal glomerulosclerosis model a prelude to novel therapy
    Virginia J Savin; Fiscal Year: 2013
    ..b>Proteinuria recurs promptly after transplantation in about 1/3 of patients with FSGS...
  41. Pro-inflammatory regulation of angiogenic gene expression in human trophoblast
    Donald S Torry; Fiscal Year: 2012
    ..anti-angiogenic" environment contributes to the clinical symptoms that define preeclampsia: hypertension and proteinuria. Although we and others have shown that oxygen tension can regulate trophoblast expression of PGF and sFlt1, we ..
  42. New Thoughts on Parietal Epithelial Cells
    Stuart Shankland; Fiscal Year: 2010
    ..However, when proteinuria is marked in primary podocyte disease, we propose that increased uptake leading to excess intra-PEC albumin ..
  43. Vascular ANGII/Jak2 in progression of renal disease
    Peter P Sayeski; Fiscal Year: 2012
    ..for blood pressure measurement by telemetry, will have metabolic cage studies to follow the development of proteinuria and total NO production and tissues/blood will be harvested for assessment of renal pathology, 24 hour ..
  44. Cross-Talk Between Estrogen and T Cells Mediated Pathways in Lupus Pathogenesis
    Alessandra B Pernis; Fiscal Year: 2010
    ..accumulation of effector T cells and IgG+ B cells, profound hypergammaglobulinemia, autoantibody production, proteinuria and glomerulonephritis. Like human SLE, development of these manifestations primarily affects the female gender...
  45. An Integrative Systems Genetics Approach to Nephrotic Syndrome
    MATTHEW GORDON SAMPSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nephrotic syndrome (NS) is a clinical syndrome of massive proteinuria caused by abnormal glomerular permeability...
  46. TNF-like weak inducer of apoptosis (TWEAK) signaling in lupus nephritis
    Chaim Putterman; Fiscal Year: 2013
    ..Preliminary studies show a beneficial effect of anti-TWEAK antibodies in reducing proteinuria in the chronic graft versus host murine model of SLE...
  47. Primary care eHealth intervention for improved outcomes in chronic kidney disease
    Veronica Yank; Fiscal Year: 2013
    ..The primary outcome will be a 4-point metric assessing control of risk factors for CKD progression (proteinuria, blood pressure, plasma glucose, cholesterol) at 12-month follow-up...
  48. VEGF Signaling in Endothelial and Glomerular Epithelial Cells in Preeclampsia
    Vesna Garovic; Fiscal Year: 2012
    Preeclampsia is a pregnancy-specific disorder clinically characterized by hypertension and proteinuria that occurs after 20 weeks of gestation...
  49. Role of KLF15 in podocyte differentiation
    Sandeep Mallipattu; Fiscal Year: 2012
    ..Although, KLF15-/- mice at baseline had only a two-fold increase in proteinuria with minimal podocyte injury, KLF15-/- mice treated with lipopolysaccharide (LPS), a murine model of podocyte ..
  50. Fat1 and Conventional Kinesin in Lateral Polarity
    DUNCAN BRUCE JOHNSTONE; Fiscal Year: 2012
    ..Deletion of fat1 in experimental mice results in abnormal development of the slit diaphragm, massive proteinuria, and death shortly after birth with nephrotic syndrome, a phenotype similar to mice deleted for nphs1 (Nephrin)...
  51. Genetic Epidemiology of Treatment Resistant Hypertension in African Americans
    CHRISTOPHER O apos BRIAN PHILLIPS; Fiscal Year: 2013
    ..higher levels of pro-inflammatory cytokines), biomarkers of acute and chronic renal injury (microalbuminuria, proteinuria and kidney injury marker-1 [KIM-1]), and increased vascular stiffness (pulse wave velocity [PWV] and ..
  52. Discover and functionally characterize full-penetrance causes of nephrosis/FSGS
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..Nephrotic syndrome (NS) is defined by significant proteinuria, resulting in hypoalbuminemia and edema...
  53. Role of the novel gene fam4b in phosphatidylserine synthesis in podocytes and mai
    HUA A LU; Fiscal Year: 2012
    ..Disruption of the slit diaphragm (SD) causes leakiness of the glomerulus, manifested as proteinuria, a typical presentation in many renal diseases...
  54. Use of PAP in women with pre-eclampsia
    LOUISE M O'BRIEN; Fiscal Year: 2013
    Pre-eclampsia is a pregnancy-specific disorder characterized by hypertension and proteinuria observed after the 20th week of gestation. It affects 5-8% of U.S...
  55. Glucocorticoid Receptor Function in Steroid Resistant Childhood Nephrotic Syndrom
    JORGE A INIGUEZ LLUHI; Fiscal Year: 2010
    Nephrotic Syndrome, characterized by massive proteinuria, hypoalbuminemia and edema, is one of the most frequently seen kidney diseases in children...
  56. Molecular Pathogenesis of Vesicoureteral Reflux
    Weining Lu; Fiscal Year: 2012
    ..Patients with VUR may present later in life with reflux nephropathy, a condition characterized by proteinuria, hypertension and focal glomerulosclerosis, which accounts for about 10% of cases of end-stage renal failure...
  57. Characterization of a novel protein required for glomerular podocyte function
    LORI L O'BRIEN; Fiscal Year: 2012
    ..This detachment is thought to be the major cause of disease symptoms such as proteinuria and will eventually lead to kidney failure in many cases...
  58. Therapeutic targeting of GSK3beta: A novel approach for podocyte protection
    Rujun Gong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Proteinuria is an invariable finding in patients with most types of chronic kidney disease and it is one of the few modifiable risk factors for long-term prognosis and progression to end stage renal ..
  59. Cell Cycle and Podocytes
    STUART JAMES SHANKLAND; Fiscal Year: 2013
    ..to study the glomerular podocytes (podo), because of their critical biological role in the prevention of proteinuria and sclerosis...
  60. Urinary Biomarkers in Biopsy Defined Early Nephropathy in Types 1 and 2 Diabetes
    S MICHAEL MAUER; Fiscal Year: 2013
    ..Also, since microalbuminuria (MA) is associated with only a 35-45% risk of progression to proteinuria (P), we will search for predictors of this progression...
  61. Prognostic Biomarkers to Predict Progression of Pediatric Chronic Kidney Disease
    ELLEN ROSE BROOKS; Fiscal Year: 2013
    ..model the relative risk of CKD progression to the level of MADs, determined by decline in mGFR, accounting for proteinuria of a non-nephrotic nature in CKD of glomerular and non-glomerular origin...
  62. Role of Protein Acetylation in Diabetic kidney Disease
    John C He; Fiscal Year: 2013
    ..MS417 also attenuates proteinuria and glomerulosclerosis in a mouse model of HIV-associated nephropathy, in which NF-kB-mediated inflammation is ..
  63. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..also develop positive ANA, antibodies to DNA, and clinical features reminiscent of human lupus including proteinuria, red cell casts, renal insufficiency, hypoalbuminemia, thrombocytopenia, alopecia, and seizures...
  64. OXIDANT MECHANISMS IN MEMBRANOUS NEPHROPATHY
    Sudhir Shah; Fiscal Year: 1993
    ..We have recently shown marked reduction in proteinuria in PHN with hydroxyl radical scavengers and an iron chelator...
  65. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..In half of this number (6-8%), maternal and fetal mortality and morbidity are threatened by the hypertension, proteinuria and pathological edema of pre-eclampsia...
  66. HIV ASSOCIATED NEPHROPATHY IN CHILDREN
    JOSE STRAUSS; Fiscal Year: 1993
    ..Most of these children initially presented with proteinuria and nephrosis...
  67. Efficacy Measures for Pediatric Lupus Studies
    Hermine Brunner; Fiscal Year: 2009
    ..variables (disease activity, MD rating of disease activity, patient rating of well-being, physical function, proteinuria, damage, growth &development) are best suited to define disease flares in cSLE and that the same cSLE core ..
  68. Role of VEGF in Glomerular Endothelial Health & Diseases
    S Karumanchi; Fiscal Year: 2007
    ..However, the mechanisms of endothelial damage and proteinuria in these disorders are poorly understood...
  69. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    Preeclampsia consists of hypertension and proteinuria in pregnancy and is the most common cause of maternal mortality if left untreated...
  70. PATHOPHYSIOLOGY OF AIDS GLOMERULOPATHY
    Bryan Myers; Fiscal Year: 1992
    ..Twenty-five AIDS patients with heavy proteinuria will then be examined with physiologic, morphometric and cell biologic techniques to elucidate the pathogenesis ..
  71. Cellular Physiology of Podocytes
    Stuart E Dryer; Fiscal Year: 2010
    ..in three podocyte proteins that will be studied in this research - TRPC6, nephrin, and Neph1- lead to severe proteinuria. However, the cellular physiology of podocytes has not been extensively studied...