- Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
Gerard M London
Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
Curr Opin Nephrol Hypertens 14:525-31. 2005
..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
- Review on uremic toxins: classification, concentration, and interindividual variability
The Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium
Kidney Int 63:1934-43. 2003
..potential uremic toxins for in vitro, ex vivo, and in vivo experiments remains a major area of concern; errors at this level might result in incorrect decisions regarding therpeutic correction of uremia and related clinical complications.
- Normal and pathologic concentrations of uremic toxins
RD Nephrologie, Montpellier, France
J Am Soc Nephrol 23:1258-70. 2012
..In summary, this review extends the classification of uremic retention solutes and their normal and uremic concentrations, and it should aid the design of experiments to study the biologic effects of these solutes in CKD...
- The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
Kidney Int 62:1524-38. 2002
..However, the pathophysiology of the disease process that links uremia, inflammation, and malnutrition with increased cardiovascular complications is not well understood...
- Effect of uremia on structure and function of immune system
Nosratola D Vaziri
Division of Nephrology and Hypertension, University of California, Orange, California, USA
J Ren Nutr 22:149-56. 2012
..This is coupled with immune deficiency that is caused by depletion of dendritic cells, naïve and central memory T cells and B cells, and impaired phagocytic function of polymorphonuclear leukocytes and monocytes...
Timothy W Meyer
Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
N Engl J Med 357:1316-25. 2007
- Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice
Ziad A Massy
INSERM Unit 507, Necker Hospital, 161, rue de Sèvres 75015 Paris, France
J Am Soc Nephrol 16:109-16. 2005
..We anticipate that this experimental model will be useful to test treatment strategies aimed at decreasing the accelerated atherosclerosis and arterial calcification in uremia.
- New insights into uremic toxicity
Amanda C Raff
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Curr Opin Nephrol Hypertens 17:560-5. 2008
Our concept of uremia has expanded to encompass the illness patients begin to suffer as glomerular filtration rate declines long before the onset of end-stage renal disease (ESRD) not explained by known derangements in volume status or ..
- Chronic uremia stimulates LDL carbamylation and atherosclerosis
Eugene O Apostolov
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Am Soc Nephrol 21:1852-7. 2010
..In summary, these data demonstrate that elevated plasma cLDL may represent an independent risk factor for uremia-induced atherosclerosis.
- IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly
Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden
Kidney Int 67:1216-33. 2005
- Uremia causes endothelial progenitor cell deficiency
Kirsten de Groot
Division of Nephrology, Department of Internal Medicine Hannover Medical School, Hannover, Germany
Kidney Int 66:641-6. 2004
..Their number in peripheral blood correlates with endothelial function and cardiovascular risk in humans. We explored whether uremia influences the number of EPCs.
- The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair
INSERM EMI0019, UFR de Pharmacie, Universite de la Mediterranee, Marseille, France
Kidney Int 65:442-51. 2004
..diseases are the major causes of mortality in uremic patients, and the vascular endothelium is dysfunctional in uremia. We hypothesized that uremic retention solutes may be among the factors involved in this endothelial dysfunction...
- Role of leptin and melanocortin signaling in uremia-associated cachexia
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Invest 115:1659-65. 2005
The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R)...
- The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells
UFR Pharmacie, Universite Aix Marseille, Marseille, France
J Thromb Haemost 5:1302-8. 2007
..Uremic solutes retained in these patients could be involved in these processes. Notably, the protein-bound uremic solute indoxyl sulfate induces endothelial dysfunction in vitro, and has shown pro-oxidant effects...
- Oxidative stress and inflammation: Implications in uremia and hemodialysis
Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo and University of Pavia, Italy
Clin Biochem 44:1189-98. 2011
- SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes
Adam M Zawada
Department of Internal Medicine IV, Saarland University Medical Center, Homburg, Germany
Circ Cardiovasc Genet 5:611-20. 2012
..We hypothesized that gene-specific epigenetic dysregulation in CKD exists, affecting genes pertinent to inflammation and atherosclerosis...
- Metabolite profiling identifies markers of uremia
Eugene P Rhee
Massachusetts General Hospital, 149 13th Street, 8th Floor, Boston, MA, USA
J Am Soc Nephrol 21:1041-1051. 2010
..In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis...
- Oxidized LDL modulates apoptosis of regulatory T cells in patients with ESRD
Service of Nephrology, Centre Hospitalier Universitaire Vaudois CHUV, 17, Rue du Bugnon, 1011 Lausanne, Switzerland
J Am Soc Nephrol 20:1368-84. 2009
..This response may contribute to the immune dysfunction, microinflammation, and atherogenesis observed in patients with ESRD...
- Uremic toxins in acute kidney injury
Rotes Kreuz Krankenhaus, Medizinische Klinik, Bremen, Germany
Semin Dial 22:445-8. 2009
..These uremic toxins may insofar be specific mediators of pathophysiological processes in AKI...
- Uremia and chronic kidney disease: the role of the gut microflora and therapies with pro- and prebiotics
Centre for Integrative Clinical and Molecular Medicine, School of Medicine at Princess Alexandra Hospital, The University of Queensland, Brisbane, Australia
Mol Nutr Food Res 57:824-32. 2013
b>Uremia is an illness that accompanies kidney failure and chronic kidney disease (CKD). Uremic illness is considered to be due largely to the accumulation of organic waste products that are normally cleared by the kidneys...
- Protein carbamylation links inflammation, smoking, uremia and atherogenesis
Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Nat Med 13:1176-84. 2007
..We propose that protein carbamylation is a mechanism linking inflammation, smoking, uremia and coronary artery disease pathogenesis.
- Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease
Kibow Biotech, Inc, 4629 West Chester Pike, Newtown Square, PA 19073, USA
Adv Ther 27:634-47. 2010
..This report presents preliminary data from a pilot study...
- Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies
Department of Nephrology, Dialysis Unit, University Hospital, Uppsala, Sweden
J Am Soc Nephrol 16:3742-7. 2005
..Nalfurafine showed similar types and incidences of drug-related adverse events as did placebo. Nalfurafine was shown to be an effective and safe compound for use in this severely ill patient population...
- An update on protein-bound uremic retention solutes
Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium
J Ren Nutr 22:90-4. 2012
..Results from large randomized trials are awaited, before these data can be considered as solid enough to warrant the recommendation to use these compounds for overall therapeutic purposes...
- Dysregulated oxygen metabolism of the kidney by uremic toxins: review
Chih Kang Chiang
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
J Ren Nutr 22:77-80. 2012
..Studies of uremic toxins will open a new avenue in development of novel therapeutic approaches of kidney disease...
- Inflammation in end-stage renal disease--what have we learned in 10 years?
Juan J Carrero
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Semin Dial 23:498-509. 2010
..Causes and consequences of inflammation, genetic heritability of the inflammatory response, implications on outcome prognostication, and contemporary therapeutic evidence are some of the various topics discussed...
- P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production
Renal Division, Department of Internal Medicine, University Hospital, De Pintelaan 185, 9000 Gent, Belgium
Nephrol Dial Transplant 22:592-6. 2007
..Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite...
- Immune dysfunction in uremia—an update
Abteilung für Nephrologie und Dialyse, Univ Klinik für Innere Medizin III, Wahringer Gurtel 18 20, Wien A 1090, Austria
Toxins (Basel) 4:962-90. 2012
..In uremia, the balance between pro- and anti-inflammatory and between pro- and anti-apoptotic factors is disturbed...
- Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury
Richard A Zager
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
Am J Physiol Renal Physiol 297:F961-70. 2009
..However, the impact of AKI-induced uremia on proinflammatory (e.g., TNF-alpha, MCP-1, TGF-beta1) and anti-inflammatory (e.g...
- Effects of uraemia and dialysis modality on polymorphonuclear cell apoptosis and function
Division of Nephrology, Department of Medicine, Federal University of Sao Paulo UNIFESP, Hospital do Rim e Hipertensão Rua Borges Lagoa 960, 4 andar 04038 002, Brazil
Nephrol Dial Transplant 21:160-5. 2006
..The aim of the current study was to investigate the effect of uraemia and dialysis modality on apoptosis and function in freshly harvested non-incubated PMN...
- Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST-120
Department of Advanced Medicine for Uremia, Nagoya University School of Medicine, Nagoya, Japan
Ther Apher Dial 15:120-4. 2011
..Experimental and clinical data demonstrate that AST-120 delays the progression not only of chronic kidney disease, but also of cardiovascular disease...
- Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia
D F Sun
Research Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
Kidney Int 70:453-9. 2006
..independent of GH, we tested whether work overload (WO) could increase skeletal muscle IGF-1 expression in uremia and thus bypass the defective GH action...
- Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
J Pharmacol Exp Ther 314:932-8. 2005
..The renal clearance of endogenous HA seems to be a useful indicator of changes in renal secretion that accompany the reduced levels of OAT protein in chronic renal failure...
- Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease
Department of Dermatology, Rabin Medical Center, Petach Tikva
J Am Acad Dermatol 49:842-6. 2003
..Pruritus is a common disabling problem in patients with advanced end-stage renal disease. Few studies have evaluated the clinical characteristics of uremic itch...
- Clinical evaluation of dietary modification for treatment of spontaneous chronic renal failure in dogs
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
J Am Vet Med Assoc 220:1163-70. 2002
..To determine whether a diet used for dogs with renal failure (renal food [RF]) was superior to an adult maintenance food (MF) in minimizing uremic crises and mortality rate in dogs with spontaneous chronic renal failure...
- Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patients
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
Amino Acids 32:573-92. 2007
..We have also evaluated therapeutic - either pharmacological or dialytic - strategies proposed to alleviate the accumulation of these toxins and to constrain the inflammatory and oxidative burden of ESRD...
- Update on the pharmacokinetics and redox properties of protein-bound uremic toxins
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
J Pharm Sci 100:3682-95. 2011
..Unfortunately, despite the massive amount of information on the undesirable effects of uremic toxins, methods for improving the detoxification of these toxins appear to be lacking...
- Ultrastructural analysis of vascular calcifications in uremia
Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
J Am Soc Nephrol 21:689-96. 2010
..study, we systematically investigated the ultrastructural properties of medial calcifications from patients with uremia. We collected iliac artery segments from 30 dialysis patients before kidney transplantation and studied them by ..
- Vascular incompetence in dialysis patients--protein-bound uremic toxins and endothelial dysfunction
INSERM U608, UFR Pharmacie, Universite Aix Marseille, Marseille, France
Semin Dial 24:327-37. 2011
..Endothelial damage induced by a uremic environment suggests an involvement of uremia-specific factors...
- Uremia impairs monocyte and monocyte-derived dendritic cell function in hemodialysis patients
W H Lim
Transplantation Immunology Laboratory and Department of Medicine, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Kidney Int 72:1138-48. 2007
..Our study suggests that hemodialysis regimes tailored to remove uremic toxins more efficiently may improve immune functions of these patients...
- Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors
Daniela Veit Barreto
Department of Internal Medicine Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
Kidney Int 67:1576-82. 2005
..is frequent in hemodialysis patients and it has been suggested that this increased incidence may be associated to uremia-related factors. The development and progression of coronary artery calcification is similar to osteogenesis...
- Uremia alters HDL composition and function
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
J Am Soc Nephrol 22:1631-41. 2011
..Assessing HDL composition and function in renal disease may help identify patients at increased risk for cardiovascular disease...
- Oxidative stress in uremia: nature, mechanisms, and potential consequences
Nosratola D Vaziri
Division of Nephrology and Hypertension, Department of Medicine, Physiology, and Hypertension, University of California Irvine, Irvine, CA, USA
Semin Nephrol 24:469-73. 2004
..The problem is compounded by limited intake of fresh fruits and vegetables (K(+) restriction), which contain numerous natural phytochemicals and antioxidant vitamins...
- Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice
Wai W Cheung
Department of Pediatric, University of California at San Diego, 9500 Gilman Drive, MC 0634, La Jolla, CA 92093 0634, USA
J Am Soc Nephrol 18:2517-24. 2007
We have recently shown that genetic or pharmacological blockade of the melanocortin-4 receptor (MC4-R) attenuates uremia-associated cachexia...
- SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation
Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan
J Am Soc Nephrol 20:2546-55. 2009
..These data suggest that drugs that upregulate SLCO4C1 may have therapeutic potential for patients with CKD...
- Lymphocyte apoptosis: role of uremia and permeability of dialysis membrane
Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
Nephron Clin Pract 100:c71-7. 2005
b>Uremia is associated to host defense mechanism disorders. Lymphocyte apoptosis, which may cause alteration of the immune system, is increased in uremic patients...
- Hypertrophy and fibrosis in the cardiomyopathy of uremia--beyond coronary heart disease
Marie Luise Gross
Department of Pathology, University of Heidelberg, Heidelberg, Germany
Semin Dial 21:308-18. 2008
- The uremic retention solute p-cresyl sulfate and markers of endothelial damage
Bjorn K I Meijers
Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
Am J Kidney Dis 54:891-901. 2009
..In hemodialysis patients, the protein-bound uremic retention solute p-cresol is independently associated with cardiovascular disease. The underlying mechanisms have not been elucidated...
- Impact of uremia, diabetes, and peritoneal dialysis itself on the pathogenesis of peritoneal sclerosis: a quantitative study of peritoneal membrane morphology
Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Clin J Am Soc Nephrol 3:720-8. 2008
- What is new in uremic toxicity?
Nephrology Section, Department of Internal Medicine, University Hospital, OK12, De Pintelaan, 185, Gent, Belgium
Pediatr Nephrol 23:1211-21. 2008
..The results of recent studies suggest that these strategies have better outcomes, thereby clinically corroborating the importance attributed in bench studies to these "difficult to remove" molecules...
- Cough headache and thoracic inlet valvular competence in uremia
Yu Ming Chuang
Department of Neurology, Keelung General Hospital, Taipei, Taiwan, Republic of China
Eur Neurol 53:78-80. 2005
..Headache is a common complaint of uremia patients...
- Profound mishandling of protein glycation degradation products in uremia and dialysis
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
J Am Soc Nephrol 16:1471-85. 2005
..Inefficient elimination of these free adducts in uremia may lead to their accumulation...
- A questionnaire for the assessment of pruritus: validation in uremic patients
Department of Dermatology, Rabin Medical Center, Petah Tiqva, Israel
Acta Derm Venereol 81:108-11. 2001
..Dialysis was not found to influence the pruritus. The questionnaire may also be useful in pruritus secondary to other causes...
- Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats
Department of Health Sciences, Oiya University of Nursing and Health Sciences, Oita 870 1201, Japan
Nephrol Dial Transplant 21:2768-74. 2006
..In this study, focusing on indoxyl sulphate (IS) as a representative UTx, we analysed the effect of an oral charcoal adsorbent AST-120, which removes uraemic toxins and their precursors from the gastrointestinal tract, on bone turnover...
- Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations
Henricus A M Mutsaers
Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 6:e18438. 2011
..Moreover, calculated Ki values are below the maximal plasma concentrations of the tested toxins. In conclusion, this study shows that several uremic toxins inhibit active transport by MRP4 and BCRP at clinically relevant concentrations...
- Uremic bleeding: pathophysiology and clinical risk factors
Avtar S Sohal
Department of Medicine, McMaster University, 25 Charlton Avenue East, Hamilton, Ontario, Canada L8N lY2
Thromb Res 118:417-22. 2006
..This article reviews the evidence, the pathophysiology and the risk factors for increased bleeding in patients with chronic renal insufficiency...
- Association of uraemic pruritus with inflammation and hepatitis infection in haemodialysis patients
Yen Ling Chiu
Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taiwan
Nephrol Dial Transplant 23:3685-9. 2008
..Chronic inflammation and hepatitis C virus (HCV) infection have been implicated in the pathogenesis of uraemic pruritus in haemodialysis (HD) patients. However, each one's independent roles have not been previously studied...
- Platelet/Leukocyte activation, inflammation, and uremia
Department of Internal Medicine, Renal Division, Ghent University Hospital, Gent, Belgium
Semin Dial 22:423-7. 2009
..The effect of specific uremic retention solutes, progressively retained in uremia, on important platelet and leukocytes functions is discussed and summarized...
- Renin-angiotensin gene polymorphism in children with uremia and essential hypertension
Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6720 Szeged, Hungary
Pediatr Nephrol 18:150-4. 2003
..Furthermore, there was a significant increase in MT genotype frequency of ANG M235T polymorphism in pediatric ESRD and JEHT. The role of AT1R gene polymorphism needs further investigation...
- Inflammation as a risk factor and target for therapy in chronic kidney disease
Division of Baxter Novum, Karolinska Institutet, Stockholm, Sweden
Curr Opin Nephrol Hypertens 20:662-8. 2011
..Inflammation is a major driving force of the uremic phenotype. This review provides an update on inflammatory biomarkers in chronic kidney disease and possible therapeutic approaches targeting the uremic inflammatory milieu...
- The gut: the forgotten organ in uremia?
Nephrology Section, University Hospital, Gent, Belgium
Blood Purif 29:130-6. 2010
..as an active player by presenting more precursors for fermentation due to disturbances in assimilation caused by uremia, followed by alterations in further processing related to changes in the composition of the fermenting flora...
- C-reactive protein and uremia
Division of Nephrology, Department of Medicine, University of Wuerzburg, Wurzburg, Germany
Semin Dial 22:438-41. 2009
..The causes for inflammation are multiple and have been well studied in the past 10 years. Nondialysis, uremia related and endogenous factors as well as the dialysis procedure itself may be responsible for the high prevalence ..
- The epigenetic conductor: a genomic orchestrator in chronic kidney disease complications?
Tomas J Ekström
Department of Clinical Neuroscience, Karolinska University Hospital at Solna, Stockholm, Sweden
J Nephrol 22:442-9. 2009
..The importance of 1-carbon metabolism for epigenetic modifications suggests that specific diets may also prove to play an important part as efficient remedies in CKD and associated atherosclerotic pathologies...
- Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration
H A M Mutsaers
Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Biochim Biophys Acta 1832:142-50. 2013
..This may have a significant impact on drug and uremic retention solute disposition in CKD patients...
- The role of EUTox in uremic toxin research
Department of Internal Medicine, Nephrology Section, University Hospital, Gent, Belgium
Semin Dial 22:323-8. 2009
..In the future, EUTox intends to continue its focus on bench to bedside research with specific consideration of proteomics, metabonomics, secretomics, and genomics...
- Uremic pruritus in chronic hemodialysis patients
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Nephrol 21:161-5. 2008
..Of all systemic disorders, uremia is the most important cause of pruritus...
- Protein damage in diabetes and uremia--identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect
Paul J Thornalley
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK
Free Radic Res 45:89-100. 2011
..The role of mathematical systems biology, bioinformatics and proteome dynamics in future investigations is discussed...
- Serum amyloid A in uremic HDL promotes inflammation
Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
J Am Soc Nephrol 23:934-47. 2012
b>Uremia impairs the atheroprotective properties of HDL, but the mechanisms underlying why this occurs are unknown...
- Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells
Department of Pharmacology, Tokyo Women s Medical University, School of Medicine, Tokyo, Japan
Kidney Int 63:1671-80. 2003
..The present study examined the signaling pathway that is activated by uremic toxins to induce PAI-1 and activate NF-kappaB in human renal proximal tubular cells (HK-2)...
- p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease
I Wen Wu
Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan
Nephrol Dial Transplant 26:938-47. 2011
..However, only a few prospective studies have evaluated possible associations between these two retained solutes and renal disease progression in chronic kidney disease (CKD) patients...
- New-onset diabetes mellitus after kidney transplantation in Denmark
Department of Nephrology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, P 2131, DK 2100 Copenhagen, Denmark
Clin J Am Soc Nephrol 5:709-16. 2010
..This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in a prospective study of 97 nondiabetic uremic patients...
- Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation
Nosratola D Vaziri
Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA, USA
Nephrol Dial Transplant 27:2686-93. 2012
..This study was designed to test the hypothesis that impaired intestinal barrier function in uremia must be due to disruption of the intestinal tight junction complex.
- Albumin is the major plasma protein target of oxidant stress in uremia
Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
Kidney Int 60:358-63. 2001
Patients with uremia are exposed to increased oxidative stress...
- Adipokines as uremic toxins
Service of Nephrology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Ren Nutr 22:81-5. 2012
..Obesity superimposed to uremia may further aggravate hyperadipokinemia, with the exception of adiponectinemia, which is mitigated by adiposity...
- Proinflammatory CD14+CD16+ monocytes are associated with microinflammation in patients with type 2 diabetes mellitus and diabetic nephropathy uremia
Department of Nephrology, First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
Inflammation 35:388-96. 2012
..expression of Toll-like receptor 4 (TLR4) and CD14(+)CD16(+) monocytes in patients with T2DM and DN patients with uremia and TLR4 response to lipopolysaccharide (LPS), and to further explore the potential effects of inflammatory immune ..
- Uremic toxins: a new focus on an old subject
Division of Nephrology and Transplantation, Akdeniz University, Antalya, Turkey
Semin Dial 18:203-11. 2005
..Our increasing knowledge of uremic toxins will help guide future treatment strategies to remove them...
- Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients
Servizio di Nefrologia e Dialisi Ospedale di Manerbio, Manerbio, BS, Italy
Am J Kidney Dis 40:590-9. 2002
..Therefore, it is expected that antioxidant therapy might exert a beneficial effect on these parameters...
- Improvements in cognition in patients converting from thrice weekly hemodialysis to nocturnal hemodialysis: a longitudinal pilot study
S V Jassal
Department of Medicine, University of Health Network, and Neurobehavioural Research Unit, St Michael s Hospital, Toronto, Ontario, Canada
Kidney Int 70:956-62. 2006
Cognitive impairment has been documented in uremia with partial improvement after dialysis. Nocturnal daily hemodialysis (NHD) is a novel dialysis modality with multiple benefits...
- Metabolomic profiling of uremic solutes in CKD patients
Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Hypertens Res 33:944-52. 2010
..These compounds provide diagnostic information and may be targets for therapies designed to treat the complications of CKD patients...
- Uraemic pruritus--new perspectives and insights from recent trials
Robert Bosch Hospital Stuttgart, Department of Internal Medicine, Division of General Internal Medicine and Nephrology, Stuttgart, Germany
Nephrol Dial Transplant 17:1558-63. 2002
- The general picture of uremia
Groupe Rein et Hypertension, Institut Universitaire de Recherche Clinique, Montpellier Cedex, Montpellier, France
Semin Dial 22:329-33. 2009
The clinical presentation and manifestations of uremia that constitute the uremic syndrome are presented...
- Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-alpha in visceral adipocytes
Mohammad A Aminzadeh
Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
Nephrol Dial Transplant 24:3626-31. 2009
..This study was designed to test the hypothesis that uraemic plasma may stimulate leptin release and suppress adiponectin release in normal adipocytes...
- HPLC study of uremic fluids related to optical dialysis adequacy monitoring
Department of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Tallinn, Estonia
Int J Artif Organs 33:96-104. 2010
The aim of this study was to investigate uremia-related high-performance liquid chromatography (HPLC) ultraviolet (UV) absorbance profiles of serum and spent dialysate and to study the removal of uremic retention solutes in connection ..
- An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats
Clinical Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
Am J Nephrol 31:160-4. 2010
..We determined if administration of an oral sorbent, AST-120, increases the expression of Klotho, and inhibits cell senescence in the kidney of CRF rats...
- Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration
Detlef H Krieter
Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
Nephrol Dial Transplant 25:212-8. 2010
..In the present study, the impact of the albumin permeability of recently introduced advanced high-flux dialysis membranes on the removal of such substances was tested in haemodialysis and online post-dilution haemodiafiltration...
- Uremic toxins modulate the spontaneous apoptotic cell death and essential functions of neutrophils
Division of Nephrology, Department of Medicine, University of Vienna, Vienna, Austria
Kidney Int Suppl 78:S48-52. 2001
..Their concentrations as well as the microenvironment in which they are acting seem to be important for their actual effects...
- Parathyroid hormone and phosphorus overload in uremia: impact on cardiovascular system
Melani R Custódio
Department of Internal Medicine, Universidade de Sao Paulo, Sao Paulo, Brazil
Nephrol Dial Transplant 27:1437-45. 2012
Cardiac remodeling in uremia is characterized by left ventricular hypertrophy, interstitial fibrosis and microvascular disease...
- CpG array analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of uremia patients
Department of Nephrology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China
DNA Cell Biol 30:179-86. 2011
Studies of the epigenome have attracted little interest in nephrology, especially in uremia. Several lines of evidence have suggested that there are links between genomic DNA hypomethylation and cardiovascular complications in uremia ..
- Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells
Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
Haematologica 87:1053-61. 2002
..Recent investigations indicate that uremia is associated with endothelial dysfunction and a microinflammatory state...
- Automated monitoring of hemodialysis adequacy by dialysis machines: potential benefits to patients and cost savings
John T Daugirdas
Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612 7323, USA
Kidney Int 78:833-5. 2010
..No disposables or reagents are required. Cost may be reduced by reducing the need for blood sampling and laboratory analysis...
- Increased platelet phosphatidylserine exposure and caspase activation in chronic uremia
Institute of Nephrology, Department of Medicine, G D Annunzio University, Chieti, Italy
J Thromb Haemost 2:1275-81. 2004
..Because platelet activation may occur in patients suffering from chronic uremia, which is frequently associated with a thrombophilic tendency, we studied whether uremic platelets show an ..
- Bilateral basal ganglia and unilateral cortical involvement in a diabetic uremic patient
Chang Hyo Yoon
Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea
Clin Neurol Neurosurg 111:477-9. 2009
..We postulated that the underlying mechanism of uremic encephalopathy based on diffusion-weighted imaging and apparent diffusion coefficient maps...
- Uremia aggravates left ventricular remodeling after myocardial infarction
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Am J Nephrol 32:13-22. 2010
Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations.
- Sexual dysfunction in uremia
B F Palmer
Department of Medicine, University of Texas Southwestern Medical School, Dallas 75235, USA
J Am Soc Nephrol 10:1381-8. 1999
..These abnormalities are primarily organic in nature and are related to uremia as well as the other comorbid conditions that frequently accompany the chronic renal failure patient...
- Pathogenesis of parathyroid hyperplasia in renal failure
Renal Division, San Paolo Hospital, Milan Italy
J Nephrol 18:5-8. 2005
..In this review, we analyze the current understanding concerning the new insights into the molecular mechanisms of parathyroid hyperplasia and PTH secretion in renal failure regulated by calcium, phosphate and vitamin D...
- Characteristics and causes of immune dysfunction related to uremia and dialysis
Aline Borsato Hauser
Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
Perit Dial Int 28:S183-7. 2008
..Understanding the mechanisms behind the immune dysfunction that is peculiar to CKD generates a perspective to improve outcomes in this group of patients...
- Factors associated with blood concentrations of indoxyl sulfate and p-cresol in patients undergoing peritoneal dialysis
Chien Te Lee
Division of Nephrology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
Perit Dial Int 30:456-63. 2010
..We conducted a cross-sectional study to analyze the factors that correlate with both total and free indoxyl sulfate and p-cresol...
- Sevelamer carbonate reduces inflammation and endotoxemia in an animal model of uremia
Aline B Hauser
Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceição 1155, Curitiba, Brazil
Blood Purif 30:153-8. 2010
..The aim of this study was to evaluate the ET-binding capacity of sevelamer carbonate in an animal model of renal failure...
- Endothelin A receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals
Department of Pathology, University of Heidelberg, Heidelberg, Germany
J Am Soc Nephrol 11:1702-11. 2000
..The results support a role of ET-1 in the genesis of left ventricular capillary/myocyte mismatch in uremia.
- AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients
INSERM U507 and Division of Nephrology, Necker Hospital, Paris, France
Kidney Int 64:82-91. 2003
..AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: A potential target forN-acetylcysteine treatment in dialysis patients...
- Arterial stiffness in predialysis patients with uremia
Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
Kidney Int 65:936-43. 2004
..We compared aortic PWV of uremic patients before starting hemodialysis treatment with that of patients on maintenance hemodialysis...