uremia

Summary

Top Publications

  1. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
  2. ncbi Review on uremic toxins: classification, concentration, and interindividual variability
    Raymond Vanholder
    The Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium
    Kidney Int 63:1934-43. 2003
  3. pmc Normal and pathologic concentrations of uremic toxins
    Flore Duranton
    RD Nephrologie, Montpellier, France
    J Am Soc Nephrol 23:1258-70. 2012
  4. ncbi The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 62:1524-38. 2002
  5. pmc Effect of uremia on structure and function of immune system
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Orange, California, USA
    J Ren Nutr 22:149-56. 2012
  6. ncbi Uremia
    Timothy W Meyer
    Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    N Engl J Med 357:1316-25. 2007
  7. ncbi Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice
    Ziad A Massy
    INSERM Unit 507, Necker Hospital, 161, rue de Sèvres 75015 Paris, France
    J Am Soc Nephrol 16:109-16. 2005
  8. ncbi New insights into uremic toxicity
    Amanda C Raff
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    Curr Opin Nephrol Hypertens 17:560-5. 2008
  9. pmc Chronic uremia stimulates LDL carbamylation and atherosclerosis
    Eugene O Apostolov
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Am Soc Nephrol 21:1852-7. 2010
  10. ncbi IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly
    Peter Stenvinkel
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Kidney Int 67:1216-33. 2005

Detail Information

Publications354 found, 100 shown here

  1. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
    ..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
  2. ncbi Review on uremic toxins: classification, concentration, and interindividual variability
    Raymond Vanholder
    The Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium
    Kidney Int 63:1934-43. 2003
    ..potential uremic toxins for in vitro, ex vivo, and in vivo experiments remains a major area of concern; errors at this level might result in incorrect decisions regarding therpeutic correction of uremia and related clinical complications.
  3. pmc Normal and pathologic concentrations of uremic toxins
    Flore Duranton
    RD Nephrologie, Montpellier, France
    J Am Soc Nephrol 23:1258-70. 2012
    ..In summary, this review extends the classification of uremic retention solutes and their normal and uremic concentrations, and it should aid the design of experiments to study the biologic effects of these solutes in CKD...
  4. ncbi The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 62:1524-38. 2002
    ..However, the pathophysiology of the disease process that links uremia, inflammation, and malnutrition with increased cardiovascular complications is not well understood...
  5. pmc Effect of uremia on structure and function of immune system
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Orange, California, USA
    J Ren Nutr 22:149-56. 2012
    ..This is coupled with immune deficiency that is caused by depletion of dendritic cells, naïve and central memory T cells and B cells, and impaired phagocytic function of polymorphonuclear leukocytes and monocytes...
  6. ncbi Uremia
    Timothy W Meyer
    Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    N Engl J Med 357:1316-25. 2007
  7. ncbi Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice
    Ziad A Massy
    INSERM Unit 507, Necker Hospital, 161, rue de Sèvres 75015 Paris, France
    J Am Soc Nephrol 16:109-16. 2005
    ..We anticipate that this experimental model will be useful to test treatment strategies aimed at decreasing the accelerated atherosclerosis and arterial calcification in uremia.
  8. ncbi New insights into uremic toxicity
    Amanda C Raff
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    Curr Opin Nephrol Hypertens 17:560-5. 2008
    Our concept of uremia has expanded to encompass the illness patients begin to suffer as glomerular filtration rate declines long before the onset of end-stage renal disease (ESRD) not explained by known derangements in volume status or ..
  9. pmc Chronic uremia stimulates LDL carbamylation and atherosclerosis
    Eugene O Apostolov
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Am Soc Nephrol 21:1852-7. 2010
    ..In summary, these data demonstrate that elevated plasma cLDL may represent an independent risk factor for uremia-induced atherosclerosis.
  10. ncbi IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly
    Peter Stenvinkel
    Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Kidney Int 67:1216-33. 2005
    ....
  11. ncbi Uremia causes endothelial progenitor cell deficiency
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine Hannover Medical School, Hannover, Germany
    Kidney Int 66:641-6. 2004
    ..Their number in peripheral blood correlates with endothelial function and cardiovascular risk in humans. We explored whether uremia influences the number of EPCs.
  12. ncbi The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair
    Laetitia Dou
    INSERM EMI0019, UFR de Pharmacie, Universite de la Mediterranee, Marseille, France
    Kidney Int 65:442-51. 2004
    ..diseases are the major causes of mortality in uremic patients, and the vascular endothelium is dysfunctional in uremia. We hypothesized that uremic retention solutes may be among the factors involved in this endothelial dysfunction...
  13. pmc Role of leptin and melanocortin signaling in uremia-associated cachexia
    Wai Cheung
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 115:1659-65. 2005
    The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R)...
  14. ncbi The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells
    L Dou
    UFR Pharmacie, Universite Aix Marseille, Marseille, France
    J Thromb Haemost 5:1302-8. 2007
    ..Uremic solutes retained in these patients could be involved in these processes. Notably, the protein-bound uremic solute indoxyl sulfate induces endothelial dysfunction in vitro, and has shown pro-oxidant effects...
  15. ncbi Oxidative stress and inflammation: Implications in uremia and hemodialysis
    Carmelo Libetta
    Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo and University of Pavia, Italy
    Clin Biochem 44:1189-98. 2011
    ....
  16. ncbi SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes
    Adam M Zawada
    Department of Internal Medicine IV, Saarland University Medical Center, Homburg, Germany
    Circ Cardiovasc Genet 5:611-20. 2012
    ..We hypothesized that gene-specific epigenetic dysregulation in CKD exists, affecting genes pertinent to inflammation and atherosclerosis...
  17. pmc Metabolite profiling identifies markers of uremia
    Eugene P Rhee
    Massachusetts General Hospital, 149 13th Street, 8th Floor, Boston, MA, USA
    J Am Soc Nephrol 21:1041-1051. 2010
    ..In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis...
  18. pmc Oxidized LDL modulates apoptosis of regulatory T cells in patients with ESRD
    Pascal Meier
    Service of Nephrology, Centre Hospitalier Universitaire Vaudois CHUV, 17, Rue du Bugnon, 1011 Lausanne, Switzerland
    J Am Soc Nephrol 20:1368-84. 2009
    ..This response may contribute to the immune dysfunction, microinflammation, and atherogenesis observed in patients with ESRD...
  19. ncbi Uremic toxins in acute kidney injury
    Stefan Herget-Rosenthal
    Rotes Kreuz Krankenhaus, Medizinische Klinik, Bremen, Germany
    Semin Dial 22:445-8. 2009
    ..These uremic toxins may insofar be specific mediators of pathophysiological processes in AKI...
  20. ncbi Uremia and chronic kidney disease: the role of the gut microflora and therapies with pro- and prebiotics
    Luis Vitetta
    Centre for Integrative Clinical and Molecular Medicine, School of Medicine at Princess Alexandra Hospital, The University of Queensland, Brisbane, Australia
    Mol Nutr Food Res 57:824-32. 2013
    b>Uremia is an illness that accompanies kidney failure and chronic kidney disease (CKD). Uremic illness is considered to be due largely to the accumulation of organic waste products that are normally cleared by the kidneys...
  21. ncbi Protein carbamylation links inflammation, smoking, uremia and atherogenesis
    Zeneng Wang
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nat Med 13:1176-84. 2007
    ..We propose that protein carbamylation is a mechanism linking inflammation, smoking, uremia and coronary artery disease pathogenesis.
  22. ncbi Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease
    Natarajan Ranganathan
    Kibow Biotech, Inc, 4629 West Chester Pike, Newtown Square, PA 19073, USA
    Adv Ther 27:634-47. 2010
    ..This report presents preliminary data from a pilot study...
  23. ncbi Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies
    Bjorn Wikstrom
    Department of Nephrology, Dialysis Unit, University Hospital, Uppsala, Sweden
    J Am Soc Nephrol 16:3742-7. 2005
    ..Nalfurafine showed similar types and incidences of drug-related adverse events as did placebo. Nalfurafine was shown to be an effective and safe compound for use in this severely ill patient population...
  24. ncbi An update on protein-bound uremic retention solutes
    Raymond Vanholder
    Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium
    J Ren Nutr 22:90-4. 2012
    ..Results from large randomized trials are awaited, before these data can be considered as solid enough to warrant the recommendation to use these compounds for overall therapeutic purposes...
  25. ncbi Dysregulated oxygen metabolism of the kidney by uremic toxins: review
    Chih Kang Chiang
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    J Ren Nutr 22:77-80. 2012
    ..Studies of uremic toxins will open a new avenue in development of novel therapeutic approaches of kidney disease...
  26. ncbi Inflammation in end-stage renal disease--what have we learned in 10 years?
    Juan J Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Semin Dial 23:498-509. 2010
    ..Causes and consequences of inflammation, genetic heritability of the inflammatory response, implications on outcome prognostication, and contemporary therapeutic evidence are some of the various topics discussed...
  27. ncbi P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production
    Eva Schepers
    Renal Division, Department of Internal Medicine, University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Nephrol Dial Transplant 22:592-6. 2007
    ..Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite...
  28. pmc Immune dysfunction in uremia—an update
    Gerald Cohen
    Abteilung für Nephrologie und Dialyse, Univ Klinik für Innere Medizin III, Wahringer Gurtel 18 20, Wien A 1090, Austria
    Toxins (Basel) 4:962-90. 2012
    ..In uremia, the balance between pro- and anti-inflammatory and between pro- and anti-apoptotic factors is disturbed...
  29. pmc Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury
    Richard A Zager
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Physiol Renal Physiol 297:F961-70. 2009
    ..However, the impact of AKI-induced uremia on proinflammatory (e.g., TNF-alpha, MCP-1, TGF-beta1) and anti-inflammatory (e.g...
  30. ncbi Effects of uraemia and dialysis modality on polymorphonuclear cell apoptosis and function
    Camila Sardenberg
    Division of Nephrology, Department of Medicine, Federal University of Sao Paulo UNIFESP, Hospital do Rim e Hipertensão Rua Borges Lagoa 960, 4 andar 04038 002, Brazil
    Nephrol Dial Transplant 21:160-5. 2006
    ..The aim of the current study was to investigate the effect of uraemia and dialysis modality on apoptosis and function in freshly harvested non-incubated PMN...
  31. ncbi Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST-120
    Toshimitsu Niwa
    Department of Advanced Medicine for Uremia, Nagoya University School of Medicine, Nagoya, Japan
    Ther Apher Dial 15:120-4. 2011
    ..Experimental and clinical data demonstrate that AST-120 delays the progression not only of chronic kidney disease, but also of cardiovascular disease...
  32. ncbi Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia
    D F Sun
    Research Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Kidney Int 70:453-9. 2006
    ..independent of GH, we tested whether work overload (WO) could increase skeletal muscle IGF-1 expression in uremia and thus bypass the defective GH action...
  33. ncbi Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats
    Tsuneo Deguchi
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Exp Ther 314:932-8. 2005
    ..The renal clearance of endogenous HA seems to be a useful indicator of changes in renal secretion that accompany the reduced levels of OAT protein in chronic renal failure...
  34. ncbi Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease
    Inbar Zucker
    Department of Dermatology, Rabin Medical Center, Petach Tikva
    J Am Acad Dermatol 49:842-6. 2003
    ..Pruritus is a common disabling problem in patients with advanced end-stage renal disease. Few studies have evaluated the clinical characteristics of uremic itch...
  35. ncbi Clinical evaluation of dietary modification for treatment of spontaneous chronic renal failure in dogs
    Frederic Jacob
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    J Am Vet Med Assoc 220:1163-70. 2002
    ..To determine whether a diet used for dogs with renal failure (renal food [RF]) was superior to an adult maintenance food (MF) in minimizing uremic crises and mortality rate in dogs with spontaneous chronic renal failure...
  36. ncbi Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patients
    M Piroddi
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
    Amino Acids 32:573-92. 2007
    ..We have also evaluated therapeutic - either pharmacological or dialytic - strategies proposed to alleviate the accumulation of these toxins and to constrain the inflammatory and oxidative burden of ESRD...
  37. ncbi Update on the pharmacokinetics and redox properties of protein-bound uremic toxins
    Hiroshi Watanabe
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Pharm Sci 100:3682-95. 2011
    ..Unfortunately, despite the massive amount of information on the undesirable effects of uremic toxins, methods for improving the detoxification of these toxins appear to be lacking...
  38. pmc Ultrastructural analysis of vascular calcifications in uremia
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 21:689-96. 2010
    ..study, we systematically investigated the ultrastructural properties of medial calcifications from patients with uremia. We collected iliac artery segments from 30 dialysis patients before kidney transplantation and studied them by ..
  39. ncbi Vascular incompetence in dialysis patients--protein-bound uremic toxins and endothelial dysfunction
    Noémie Jourde-Chiche
    INSERM U608, UFR Pharmacie, Universite Aix Marseille, Marseille, France
    Semin Dial 24:327-37. 2011
    ..Endothelial damage induced by a uremic environment suggests an involvement of uremia-specific factors...
  40. ncbi Uremia impairs monocyte and monocyte-derived dendritic cell function in hemodialysis patients
    W H Lim
    Transplantation Immunology Laboratory and Department of Medicine, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Kidney Int 72:1138-48. 2007
    ..Our study suggests that hemodialysis regimes tailored to remove uremic toxins more efficiently may improve immune functions of these patients...
  41. ncbi Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors
    Daniela Veit Barreto
    Department of Internal Medicine Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Kidney Int 67:1576-82. 2005
    ..is frequent in hemodialysis patients and it has been suggested that this increased incidence may be associated to uremia-related factors. The development and progression of coronary artery calcification is similar to osteogenesis...
  42. pmc Uremia alters HDL composition and function
    Michael Holzer
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
    J Am Soc Nephrol 22:1631-41. 2011
    ..Assessing HDL composition and function in renal disease may help identify patients at increased risk for cardiovascular disease...
  43. ncbi Oxidative stress in uremia: nature, mechanisms, and potential consequences
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, Physiology, and Hypertension, University of California Irvine, Irvine, CA, USA
    Semin Nephrol 24:469-73. 2004
    ..The problem is compounded by limited intake of fresh fruits and vegetables (K(+) restriction), which contain numerous natural phytochemicals and antioxidant vitamins...
  44. ncbi Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice
    Wai W Cheung
    Department of Pediatric, University of California at San Diego, 9500 Gilman Drive, MC 0634, La Jolla, CA 92093 0634, USA
    J Am Soc Nephrol 18:2517-24. 2007
    We have recently shown that genetic or pharmacological blockade of the melanocortin-4 receptor (MC4-R) attenuates uremia-associated cachexia...
  45. pmc SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation
    Takafumi Toyohara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan
    J Am Soc Nephrol 20:2546-55. 2009
    ..These data suggest that drugs that upregulate SLCO4C1 may have therapeutic potential for patients with CKD...
  46. ncbi Lymphocyte apoptosis: role of uremia and permeability of dialysis membrane
    Sagrario Soriano
    Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Nephron Clin Pract 100:c71-7. 2005
    b>Uremia is associated to host defense mechanism disorders. Lymphocyte apoptosis, which may cause alteration of the immune system, is increased in uremic patients...
  47. ncbi Hypertrophy and fibrosis in the cardiomyopathy of uremia--beyond coronary heart disease
    Marie Luise Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Semin Dial 21:308-18. 2008
    ....
  48. ncbi The uremic retention solute p-cresyl sulfate and markers of endothelial damage
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Am J Kidney Dis 54:891-901. 2009
    ..In hemodialysis patients, the protein-bound uremic retention solute p-cresol is independently associated with cardiovascular disease. The underlying mechanisms have not been elucidated...
  49. pmc Impact of uremia, diabetes, and peritoneal dialysis itself on the pathogenesis of peritoneal sclerosis: a quantitative study of peritoneal membrane morphology
    Kazuho Honda
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Clin J Am Soc Nephrol 3:720-8. 2008
    ..g., uremia)...
  50. pmc What is new in uremic toxicity?
    Raymond Vanholder
    Nephrology Section, Department of Internal Medicine, University Hospital, OK12, De Pintelaan, 185, Gent, Belgium
    Pediatr Nephrol 23:1211-21. 2008
    ..The results of recent studies suggest that these strategies have better outcomes, thereby clinically corroborating the importance attributed in bench studies to these "difficult to remove" molecules...
  51. ncbi Cough headache and thoracic inlet valvular competence in uremia
    Yu Ming Chuang
    Department of Neurology, Keelung General Hospital, Taipei, Taiwan, Republic of China
    Eur Neurol 53:78-80. 2005
    ..Headache is a common complaint of uremia patients...
  52. ncbi Profound mishandling of protein glycation degradation products in uremia and dialysis
    Stamatina Agalou
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    J Am Soc Nephrol 16:1471-85. 2005
    ..Inefficient elimination of these free adducts in uremia may lead to their accumulation...
  53. ncbi A questionnaire for the assessment of pruritus: validation in uremic patients
    G Yosipovitch
    Department of Dermatology, Rabin Medical Center, Petah Tiqva, Israel
    Acta Derm Venereol 81:108-11. 2001
    ..Dialysis was not found to influence the pruritus. The questionnaire may also be useful in pruritus secondary to other causes...
  54. ncbi Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats
    Yoshiko Iwasaki
    Department of Health Sciences, Oiya University of Nursing and Health Sciences, Oita 870 1201, Japan
    Nephrol Dial Transplant 21:2768-74. 2006
    ..In this study, focusing on indoxyl sulphate (IS) as a representative UTx, we analysed the effect of an oral charcoal adsorbent AST-120, which removes uraemic toxins and their precursors from the gastrointestinal tract, on bone turnover...
  55. pmc Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations
    Henricus A M Mutsaers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e18438. 2011
    ..Moreover, calculated Ki values are below the maximal plasma concentrations of the tested toxins. In conclusion, this study shows that several uremic toxins inhibit active transport by MRP4 and BCRP at clinically relevant concentrations...
  56. ncbi Uremic bleeding: pathophysiology and clinical risk factors
    Avtar S Sohal
    Department of Medicine, McMaster University, 25 Charlton Avenue East, Hamilton, Ontario, Canada L8N lY2
    Thromb Res 118:417-22. 2006
    ..This article reviews the evidence, the pathophysiology and the risk factors for increased bleeding in patients with chronic renal insufficiency...
  57. ncbi Association of uraemic pruritus with inflammation and hepatitis infection in haemodialysis patients
    Yen Ling Chiu
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taiwan
    Nephrol Dial Transplant 23:3685-9. 2008
    ..Chronic inflammation and hepatitis C virus (HCV) infection have been implicated in the pathogenesis of uraemic pruritus in haemodialysis (HD) patients. However, each one's independent roles have not been previously studied...
  58. ncbi Platelet/Leukocyte activation, inflammation, and uremia
    Griet Glorieux
    Department of Internal Medicine, Renal Division, Ghent University Hospital, Gent, Belgium
    Semin Dial 22:423-7. 2009
    ..The effect of specific uremic retention solutes, progressively retained in uremia, on important platelet and leukocytes functions is discussed and summarized...
  59. ncbi Renin-angiotensin gene polymorphism in children with uremia and essential hypertension
    Ferenc Papp
    Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6720 Szeged, Hungary
    Pediatr Nephrol 18:150-4. 2003
    ..Furthermore, there was a significant increase in MT genotype frequency of ANG M235T polymorphism in pediatric ESRD and JEHT. The role of AT1R gene polymorphism needs further investigation...
  60. ncbi Inflammation as a risk factor and target for therapy in chronic kidney disease
    Tetsu Miyamoto
    Division of Baxter Novum, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Nephrol Hypertens 20:662-8. 2011
    ..Inflammation is a major driving force of the uremic phenotype. This review provides an update on inflammatory biomarkers in chronic kidney disease and possible therapeutic approaches targeting the uremic inflammatory milieu...
  61. ncbi The gut: the forgotten organ in uremia?
    Eva Schepers
    Nephrology Section, University Hospital, Gent, Belgium
    Blood Purif 29:130-6. 2010
    ..as an active player by presenting more precursors for fermentation due to disturbances in assimilation caused by uremia, followed by alterations in further processing related to changes in the composition of the fermenting flora...
  62. ncbi C-reactive protein and uremia
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wuerzburg, Wurzburg, Germany
    Semin Dial 22:438-41. 2009
    ..The causes for inflammation are multiple and have been well studied in the past 10 years. Nondialysis, uremia related and endogenous factors as well as the dialysis procedure itself may be responsible for the high prevalence ..
  63. ncbi The epigenetic conductor: a genomic orchestrator in chronic kidney disease complications?
    Tomas J Ekström
    Department of Clinical Neuroscience, Karolinska University Hospital at Solna, Stockholm, Sweden
    J Nephrol 22:442-9. 2009
    ..The importance of 1-carbon metabolism for epigenetic modifications suggests that specific diets may also prove to play an important part as efficient remedies in CKD and associated atherosclerotic pathologies...
  64. ncbi Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration
    H A M Mutsaers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochim Biophys Acta 1832:142-50. 2013
    ..This may have a significant impact on drug and uremic retention solute disposition in CKD patients...
  65. ncbi The role of EUTox in uremic toxin research
    Raymond Vanholder
    Department of Internal Medicine, Nephrology Section, University Hospital, Gent, Belgium
    Semin Dial 22:323-8. 2009
    ..In the future, EUTox intends to continue its focus on bench to bedside research with specific consideration of proteomics, metabonomics, secretomics, and genomics...
  66. ncbi Uremic pruritus in chronic hemodialysis patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 21:161-5. 2008
    ..Of all systemic disorders, uremia is the most important cause of pruritus...
  67. ncbi Protein damage in diabetes and uremia--identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect
    Paul J Thornalley
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK
    Free Radic Res 45:89-100. 2011
    ..The role of mathematical systems biology, bioinformatics and proteome dynamics in future investigations is discussed...
  68. pmc Serum amyloid A in uremic HDL promotes inflammation
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    J Am Soc Nephrol 23:934-47. 2012
    b>Uremia impairs the atheroprotective properties of HDL, but the mechanisms underlying why this occurs are unknown...
  69. ncbi Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells
    Masaru Motojima
    Department of Pharmacology, Tokyo Women s Medical University, School of Medicine, Tokyo, Japan
    Kidney Int 63:1671-80. 2003
    ..The present study examined the signaling pathway that is activated by uremic toxins to induce PAI-1 and activate NF-kappaB in human renal proximal tubular cells (HK-2)...
  70. pmc p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease
    I Wen Wu
    Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan
    Nephrol Dial Transplant 26:938-47. 2011
    ..However, only a few prospective studies have evaluated possible associations between these two retained solutes and renal disease progression in chronic kidney disease (CKD) patients...
  71. pmc New-onset diabetes mellitus after kidney transplantation in Denmark
    Mads Hornum
    Department of Nephrology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, P 2131, DK 2100 Copenhagen, Denmark
    Clin J Am Soc Nephrol 5:709-16. 2010
    ..This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in a prospective study of 97 nondiabetic uremic patients...
  72. pmc Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 27:2686-93. 2012
    ..This study was designed to test the hypothesis that impaired intestinal barrier function in uremia must be due to disruption of the intestinal tight junction complex.
  73. ncbi Albumin is the major plasma protein target of oxidant stress in uremia
    J Himmelfarb
    Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 60:358-63. 2001
    Patients with uremia are exposed to increased oxidative stress...
  74. ncbi Adipokines as uremic toxins
    Daniel Teta
    Service of Nephrology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Ren Nutr 22:81-5. 2012
    ..Obesity superimposed to uremia may further aggravate hyperadipokinemia, with the exception of adiponectinemia, which is mitigated by adiposity...
  75. ncbi Proinflammatory CD14+CD16+ monocytes are associated with microinflammation in patients with type 2 diabetes mellitus and diabetic nephropathy uremia
    Mengxue Yang
    Department of Nephrology, First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
    Inflammation 35:388-96. 2012
    ..expression of Toll-like receptor 4 (TLR4) and CD14(+)CD16(+) monocytes in patients with T2DM and DN patients with uremia and TLR4 response to lipopolysaccharide (LPS), and to further explore the potential effects of inflammatory immune ..
  76. ncbi Uremic toxins: a new focus on an old subject
    Asuman Yavuz
    Division of Nephrology and Transplantation, Akdeniz University, Antalya, Turkey
    Semin Dial 18:203-11. 2005
    ..Our increasing knowledge of uremic toxins will help guide future treatment strategies to remove them...
  77. ncbi Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients
    Mario Usberti
    Servizio di Nefrologia e Dialisi Ospedale di Manerbio, Manerbio, BS, Italy
    Am J Kidney Dis 40:590-9. 2002
    ..Therefore, it is expected that antioxidant therapy might exert a beneficial effect on these parameters...
  78. ncbi Improvements in cognition in patients converting from thrice weekly hemodialysis to nocturnal hemodialysis: a longitudinal pilot study
    S V Jassal
    Department of Medicine, University of Health Network, and Neurobehavioural Research Unit, St Michael s Hospital, Toronto, Ontario, Canada
    Kidney Int 70:956-62. 2006
    Cognitive impairment has been documented in uremia with partial improvement after dialysis. Nocturnal daily hemodialysis (NHD) is a novel dialysis modality with multiple benefits...
  79. ncbi Metabolomic profiling of uremic solutes in CKD patients
    Takafumi Toyohara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 33:944-52. 2010
    ..These compounds provide diagnostic information and may be targets for therapies designed to treat the complications of CKD patients...
  80. ncbi Uraemic pruritus--new perspectives and insights from recent trials
    Thomas Mettang
    Robert Bosch Hospital Stuttgart, Department of Internal Medicine, Division of General Internal Medicine and Nephrology, Stuttgart, Germany
    Nephrol Dial Transplant 17:1558-63. 2002
  81. ncbi The general picture of uremia
    Cyrielle Almeras
    Groupe Rein et Hypertension, Institut Universitaire de Recherche Clinique, Montpellier Cedex, Montpellier, France
    Semin Dial 22:329-33. 2009
    The clinical presentation and manifestations of uremia that constitute the uremic syndrome are presented...
  82. ncbi Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-alpha in visceral adipocytes
    Mohammad A Aminzadeh
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 24:3626-31. 2009
    ..This study was designed to test the hypothesis that uraemic plasma may stimulate leptin release and suppress adiponectin release in normal adipocytes...
  83. ncbi HPLC study of uremic fluids related to optical dialysis adequacy monitoring
    Kai Lauri
    Department of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Tallinn, Estonia
    Int J Artif Organs 33:96-104. 2010
    The aim of this study was to investigate uremia-related high-performance liquid chromatography (HPLC) ultraviolet (UV) absorbance profiles of serum and spent dialysate and to study the removal of uremic retention solutes in connection ..
  84. ncbi An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats
    Ayinuer Adijiang
    Clinical Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Am J Nephrol 31:160-4. 2010
    ..We determined if administration of an oral sorbent, AST-120, increases the expression of Klotho, and inhibits cell senescence in the kidney of CRF rats...
  85. ncbi Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration
    Detlef H Krieter
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 25:212-8. 2010
    ..In the present study, the impact of the albumin permeability of recently introduced advanced high-flux dialysis membranes on the removal of such substances was tested in haemodialysis and online post-dilution haemodiafiltration...
  86. ncbi Uremic toxins modulate the spontaneous apoptotic cell death and essential functions of neutrophils
    G Cohen
    Division of Nephrology, Department of Medicine, University of Vienna, Vienna, Austria
    Kidney Int Suppl 78:S48-52. 2001
    ..Their concentrations as well as the microenvironment in which they are acting seem to be important for their actual effects...
  87. ncbi Parathyroid hormone and phosphorus overload in uremia: impact on cardiovascular system
    Melani R Custódio
    Department of Internal Medicine, Universidade de Sao Paulo, Sao Paulo, Brazil
    Nephrol Dial Transplant 27:1437-45. 2012
    Cardiac remodeling in uremia is characterized by left ventricular hypertrophy, interstitial fibrosis and microvascular disease...
  88. ncbi CpG array analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of uremia patients
    Li Zhang
    Department of Nephrology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China
    DNA Cell Biol 30:179-86. 2011
    Studies of the epigenome have attracted little interest in nephrology, especially in uremia. Several lines of evidence have suggested that there are links between genomic DNA hypomethylation and cardiovascular complications in uremia ..
  89. ncbi Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells
    Mireia Serradell
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Haematologica 87:1053-61. 2002
    ..Recent investigations indicate that uremia is associated with endothelial dysfunction and a microinflammatory state...
  90. ncbi Automated monitoring of hemodialysis adequacy by dialysis machines: potential benefits to patients and cost savings
    John T Daugirdas
    Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612 7323, USA
    Kidney Int 78:833-5. 2010
    ..No disposables or reagents are required. Cost may be reduced by reducing the need for blood sampling and laboratory analysis...
  91. ncbi Increased platelet phosphatidylserine exposure and caspase activation in chronic uremia
    M Bonomini
    Institute of Nephrology, Department of Medicine, G D Annunzio University, Chieti, Italy
    J Thromb Haemost 2:1275-81. 2004
    ..Because platelet activation may occur in patients suffering from chronic uremia, which is frequently associated with a thrombophilic tendency, we studied whether uremic platelets show an ..
  92. ncbi Bilateral basal ganglia and unilateral cortical involvement in a diabetic uremic patient
    Chang Hyo Yoon
    Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea
    Clin Neurol Neurosurg 111:477-9. 2009
    ..We postulated that the underlying mechanism of uremic encephalopathy based on diffusion-weighted imaging and apparent diffusion coefficient maps...
  93. ncbi Uremia aggravates left ventricular remodeling after myocardial infarction
    Ralf Dikow
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Am J Nephrol 32:13-22. 2010
    Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations.
  94. ncbi Sexual dysfunction in uremia
    B F Palmer
    Department of Medicine, University of Texas Southwestern Medical School, Dallas 75235, USA
    J Am Soc Nephrol 10:1381-8. 1999
    ..These abnormalities are primarily organic in nature and are related to uremia as well as the other comorbid conditions that frequently accompany the chronic renal failure patient...
  95. ncbi Pathogenesis of parathyroid hyperplasia in renal failure
    Mario Cozzolino
    Renal Division, San Paolo Hospital, Milan Italy
    J Nephrol 18:5-8. 2005
    ..In this review, we analyze the current understanding concerning the new insights into the molecular mechanisms of parathyroid hyperplasia and PTH secretion in renal failure regulated by calcium, phosphate and vitamin D...
  96. ncbi Characteristics and causes of immune dysfunction related to uremia and dialysis
    Aline Borsato Hauser
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
    Perit Dial Int 28:S183-7. 2008
    ..Understanding the mechanisms behind the immune dysfunction that is peculiar to CKD generates a perspective to improve outcomes in this group of patients...
  97. ncbi Factors associated with blood concentrations of indoxyl sulfate and p-cresol in patients undergoing peritoneal dialysis
    Chien Te Lee
    Division of Nephrology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
    Perit Dial Int 30:456-63. 2010
    ..We conducted a cross-sectional study to analyze the factors that correlate with both total and free indoxyl sulfate and p-cresol...
  98. ncbi Sevelamer carbonate reduces inflammation and endotoxemia in an animal model of uremia
    Aline B Hauser
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceição 1155, Curitiba, Brazil
    Blood Purif 30:153-8. 2010
    ..The aim of this study was to evaluate the ET-binding capacity of sevelamer carbonate in an animal model of renal failure...
  99. ncbi Endothelin A receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals
    K Amann
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 11:1702-11. 2000
    ..The results support a role of ET-1 in the genesis of left ventricular capillary/myocyte mismatch in uremia.
  100. ncbi AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients
    Véronique Witko-Sarsat
    INSERM U507 and Division of Nephrology, Necker Hospital, Paris, France
    Kidney Int 64:82-91. 2003
    ..AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: A potential target forN-acetylcysteine treatment in dialysis patients...
  101. ncbi Arterial stiffness in predialysis patients with uremia
    Kayo Shinohara
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Int 65:936-43. 2004
    ..We compared aortic PWV of uremic patients before starting hemodialysis treatment with that of patients on maintenance hemodialysis...

Research Grants64

  1. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..J. Chan, Scheinman; growth failure and growth hormone secretion and female reproductive functions in uremia (Drs. Krieg, J. Chan); parenchymal and vascular cell injury and response (Dr...
  2. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..However, processes underlying intimal hyperplasia in the setting of uremia, and, specifically, in the venous outflow of hemodialysis AV fistulas, have not been delineated...
  3. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..understanding of the mechanisms behind muscle wasting and the exaggerated atrophy that occurs during disuse in uremia. The study will be carried out with muscle biopsied from normal and end-stage CKD patients, CKD rats with muscle ..
  4. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..chronic kidney disease (CKD) may or may not benefit from the initiation of dialysis in the absence of symptomatic uremia (accumulation of the bloodstream with by- products of metabolism)...
  5. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    ..cyclosporine or tacrolimus) and;(4) increased dietary caloric load secondary to the abrogation of chronic uremia-related anorexia...
  6. Mechanisms of cLDL-Induced Endothelial Injury
    Sudhir V Shah; Fiscal Year: 2013
    ..Aim 3. Test whether genetic inactivation of EndoG or inhibition of mechanisms upregulating EndoG attenuate uremia/cLDL-induced endothelial cell injury and atherosclerosis...
  7. Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
    Ralph Rabkin; Fiscal Year: 2009
    ..Furthermore the study should provide new insight into the molecular mechanisms of muscle wasting in uremia. If effective as anticipated, this TT replacement strategy will form the basis for more extensive studies of TT ..
  8. Vascular Structure and Function in Arteriovenous Fistula Maturation
    Jonathan Himmelfarb; Fiscal Year: 2012
    ..There is now substantial evidence that uremia is accompanied by increased oxidative stress, and inflammation, leading to endothelial dysfunction and structural ..
  9. Skeletal muscle function and mitochondrial metabolism in non-diabetic CKD
    Baback Roshanravan; Fiscal Year: 2012
    ..better understanding of the role of skeletal muscle dysfunction in CKD will help link the metabolic consequence of uremia with functional impairment as well as cardiovascular morbidity and mortality...
  10. Omega-3 Fatty Acid Administration In Dialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2010
    ..of this grant application is to examine the role of EPA supplementation in ameliorating the inflammatory state of uremia and the related muscle protein catabolism associated with this disease state...
  11. Immune Dysregulation in Uremia
    Neal B Blatt; Fiscal Year: 2013
    ..Ultimately, it is hoped that these studies will lead to the development of new methods to reset immune responses in ESRD, and help to prevent both cardiovascular disease and lethal infections. ..
  12. The Mechanism of Uremia Induced Vascular Calcification
    Sharon M Moe; Fiscal Year: 2013
    ..We have previously demonstrated that uremia is a major risk factor and in vitro studies show that the effect of uremia on vascular smooth muscle cells (VSMC) ..
  13. Molecular Mechanisms of Age-related Muscle Loss
    Christopher M Adams; Fiscal Year: 2013
    ..of a small number of mRNAs increased by a variety of acute atrophy-inducing stresses (fasting, cancer, diabetes, uremia and muscle denervation)...
  14. Mechanisms involved in uremic toxin mediated down regulation of ApoA-I expression
    Hamid Moradi; Fiscal Year: 2011
    ..ApoA-l promoter-luciferase construct, we have shown decreased ApoA-l promoter activity in liver cells exposed to uremia. Furthermore, we believe this inhibitory effect is mediated through a uremia responsive element (URE) within the ..
  15. MicroRNA and Muscle Wasting in Uremia
    XIAONAN H WANG; Fiscal Year: 2013
    ..These results should provide new approaches for developing therapeutic strategies to correct muscle wasting in catabolic disease. ..
  16. PROTEIN NUTRITION IN EXPERIMENTAL UREMIA
    WILLIAM EVANS MITCH; Fiscal Year: 2013
    ..Our long-term goal is to identify uremia-induced mechanisms causing muscle loss in order to devise novel therapies to combat this problem...
  17. Metabolite Profiling and Cardiovascular Mortality in End-stage Renal Disease
    Eugene P Rhee; Fiscal Year: 2013
    ..The applicant's long-term goal is to become an R01 funded investigator with expertise in uremia. Environment: Dr. Rhee's mentors provide complementary expertise. Dr...
  18. Mechanisms of uremic vascular calcification
    Koba A Lomashvili; Fiscal Year: 2013
    ..Using rat and mouse uremia models, as well as in vitro model of vascular calcification the applicant will investigate temporal and spatial ..
  19. Novel antithrombotic agents to prevent hemodialysis vascular access failure
    TZE CHEIN WUN; Fiscal Year: 2013
    ..Surgical trauma, repeated needle punctures, mechanical shear stress, the foreign graft material and uremia can elicit a strong thrombotic response that lays down a mural fibrin- and platelet-rich substrate on which ..
  20. Outcomes, Costs and Trends in Dialysis Timing in VA
    ANN M O'HARE; Fiscal Year: 2013
    ..is often based on declining levels of the estimated Glomerular Filtration Rate (eGFR) and patient symptoms of uremia, such as fatigue and weight loss, but optimal timing for dialysis is not well understood...
  21. Role of Bone Marrow-Derived Fibroblast Precursors in Cardiac Fibrosis
    Yanlin Wang; Fiscal Year: 2013
    ..To test this hypothesis, the following specific aims will be pursued. Specific Aim 1 is to determine whether uremia stimulates chemokine production followed by accumulation of fibroblast precursors in the heart...
  22. Research Training in Renal Diseases
    WILLIAM EVANS MITCH; Fiscal Year: 2013
    ..g, how uremia influences vascular complications, protein metabolism, etc.)...
  23. Mitochondrial Injury in the Anemia of Chronic Kidney Disease
    Madhumathi Rao; Fiscal Year: 2010
    ..Recent advances point to the emerging association of mitochondrial injury with uremia, oxidative stress and inflammation. Mitochondria have key roles in the marrow response to EPO and heme synthesis...
  24. Biodegradable Magensium Stents to Enhance AV Fistula Maturation
    Prabir Roy-Chaudhury; Fiscal Year: 2013
    ..not allow for the release of vasodilator molecules such as nitric oxide and (c) abnormal vascular biology due to uremia and oxidative stress...
  25. Role of Wnt signaling in uremia-induced entothelial dysfunction
    Vipul C Chitalia; Fiscal Year: 2013
    ..This work will be the first detailed functional analysis of the role of signaling pathway in uremia-induced endothelial dysfunction. The applicant is an Instructor in Medicine and is pursing a Ph.D...
  26. Effects of Vascular Runx 2 deletion on osteogenesis and calcification in vessels
    Koba A Lomashvili; Fiscal Year: 2013
    ..and test the effect of complete inhibition of VSMC osteogenic differentiation on vascular calcification in uremia. We also propose to examine if Runx2 overexpression is capable of launching osteogenic program in vessels in ..
  27. DEVELOPMENT OF A SYNTHETIC VON WILLEBRAND FACTOR
    Dennis Lynch; Fiscal Year: 1992
    ..with apparently normal vWF synthetic capability, may sometimes require vWF supplementation in situations such as uremia or after prolonged cardiac by-pass surgery. Many will respond to DDAVP, but others require cryoprecipitate...
  28. ERYTHROPOIETIN THERAPY IN RENAL FAILURE
    JOSEPH ESCHBACH; Fiscal Year: 1991
    ..be studied to see if the reciprocal changes in Ep production and erythropoiesis, observed in normals, are found in uremia or whether these changes will be blunted or non-existent...
  29. ABNORMALITIES OF PLATELET CALCIUM IN DISEASE
    J Ware; Fiscal Year: 1991
    ..The Ca++ abnormalities will be compared to those found in platelets from patients with uremia, which is associated with a prolonged bleeding time for reasons that are unclear...
  30. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..Inhibition of EGFR activation by AG1478, a highly specific EGFR-tyrosine kinase inhibitor (TKI), reduces uremia- and high P-induced PT hyperplasia by 60%...
  31. PSYCHOSOCIAL HYPERTENSION, CATECHOLAMINES AND DRUGS
    James Henry; Fiscal Year: 1980
    ..An interstitial nephritis also develops. As many as 20% of males die in uremia by 6-9 months...
  32. EXTRA-RENAL REGULATION OF POTASSIUM HOMEOSTASIS
    ALICIA MCDONOUGH; Fiscal Year: 2004
    ..both NKA a2 and NKCC1 coupled to resistance to insulin stimulated K+ uptake, and that this process is altered in uremia accompanying chronic renal failure...
  33. CARDIOVASCULAR RISK FACTORS--CHRONIC RENAL INSUFFICIENCY
    Mark Sarnak; Fiscal Year: 2004
    ..is that the progression of CVD and chronic renal disease share common mechanisms; and that "traditional" and "uremia-related" risk factors, in particular total plasma homocysteine (tHcy), lipoprotein(a) (Lp(a)) and C-reactive ..
  34. CYANASE AND THE CYANASE OPERON
    Paul Anderson; Fiscal Year: 1993
    ..administration as a drug or originating naturally from spontaneous breakdown of urea (present at high levels in uremia or chronic diarrhea) or as an environmental pollutant can have undesirable pharmacological effects...
  35. REGULATION OF CELL METABOLISM IN UREMIA
    JACK METCOFF; Fiscal Year: 1980
    It is hypothesized that the known defects for metabolism of CHO, proteins and lipids in uremia result from an imbalance of some positive and/or negative effectors of key enzymes which regulate these pathways...
  36. CLINICAL MODEL OF ERYTHROPOIETIN GENE THERAPY
    William Osborne; Fiscal Year: 1999
    ..fistulae across the carotid artery and jugular vein to treat the anemia of sheep with surgically induced stable uremia. This research may be applied to patients with chronic renal failure who are subject to dialysis and require ..
  37. Comparison of exercise responses in four ESRD treatments
    Patricia Painter; Fiscal Year: 2006
    ..It is suspected that factors associated with uremia impair the normal integration of physiological systems required for increased oxygen transport and utilization ..
  38. METABOLISM OF PROPRANOLOL IN UREMIC RAT LIVER
    Danny Shen; Fiscal Year: 1991
    ..b>Uremia-induced inhibition of metabolic clearance has been reported with several of the newer beta-blockers and various ..
  39. IGF-I RESISTANCE IN CHRONIC UREMIA
    Ralph Rabkin; Fiscal Year: 1999
    ..Whether such a defect in tissue responsiveness occurs in children with chronic uremia is not known...
  40. Oxidative Stress and Hemodialysis Access Failure
    MIRIAM WEISS; Fiscal Year: 2002
    ..There is a great deal of evidence for increased oxidative stress in uremia. The rationale for this proposal stems from emerging evidence for efficacy of vitamin E in uremia...
  41. Novel Cardiovascular Risk Factors in Renal Insufficiency
    Sylvia Rosas; Fiscal Year: 2005
    ..Task Force on Cardiovascular Disease concluded that emphasis should be placed on risk factors related to uremia such as proteinuria, elevated Lp(a) and homocysteine whose adverse profile worsens as the chronic kidney disease (..
  42. UREMIA--EFFECTS ON INSULIN BINDING & RECEPTOR FUNCTION
    Robert May; Fiscal Year: 1993
    b>Uremia is a state characterized by muscle protein wasting and insulin resistance...
  43. LDL isoforms in kidney-related atherosclerosisv
    Alexei Basnakian; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) with or without uremia affects approximately 10% of worldwide population and increases the risk of developing cardiovascular diseases to several times that of persons with ..
  44. Apoptosis of Neutrophils in Uremia
    MARY PERIANAYAGAM; Fiscal Year: 2004
    ..The results are expected to enhance our understanding of leukocyte biology in CRF, and lay the foundation for developing novel strategies to combat immune dysfunction in CRF. ..
  45. MECHANISM AND SIGNIFIANCE OF AGE ACCUMULATION IN ESRD
    MIRIAM WEISS; Fiscal Year: 2000
    ..Because AGEs bind metal ions, creating a highly oxidizing metal-protein complex, oxidant stress in uremia may be caused by increased AGE formation on proteins. A good marker of uremic toxicity has yet been defined...
  46. Urinary Biomarkers for Steroid Resistant Nephrotic Syndr
    Robert Mak; Fiscal Year: 2005
    ..We believe that data from the current study will improve our diagnostic and therapeutic strategy and may provide clues to the pathogenetic significance of the identified biomarkers. ..
  47. Molecular Analysis of Ureteric Reflux
    Robert Mak; Fiscal Year: 2006
    ..A clinical database of primary VUR and RN will be set up to establish correlations between biomarkers and phenotype and to test the sensitivity and specificity of these markers for detecting primary VUR and RN. ..
  48. Continuation of Dialysis Access Consortium Clinical Trials
    Jonathan Himmelfarb; Fiscal Year: 2007
    ..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..
  49. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  50. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  51. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
    ..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
  52. MALNUTRITION IN DIALYSIS PATIENTS
    TALAT IKIZLER; Fiscal Year: 2006
    ..abstract_text> ..
  53. Removal of Protein-Bound Solutes by Dialysis
    Timothy Meyer; Fiscal Year: 2007
    ..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..