chronic kidney failure

Summary

Summary: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Top Publications

  1. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
  2. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
  3. ncbi Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
    Ying Chun Ma
    Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, No 8 Xishiku Street, Xicheng District, Beijing 100034, PR China
    J Am Soc Nephrol 17:2937-44. 2006
  4. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
  5. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
  6. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
  7. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
  8. ncbi Vitamin D levels and early mortality among incident hemodialysis patients
    M Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 72:1004-13. 2007
  9. ncbi Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002
  10. ncbi Chronic kidney disease: the global challenge
    A Meguid El Nahas
    Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
    Lancet 365:331-40. 2005

Detail Information

Publications350 found, 100 shown here

  1. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
    ..Disorders of mineral metabolism are independently associated with mortality and morbidity associated with cardiovascular disease and fracture in hemodialysis patients...
  2. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
    ..Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR)...
  3. ncbi Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
    Ying Chun Ma
    Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, No 8 Xishiku Street, Xicheng District, Beijing 100034, PR China
    J Am Soc Nephrol 17:2937-44. 2006
    ..The modified MDRD equations that were based on the Chinese patients with CKD offered significant advantages in different CKD stages and could be applied in clinical practice, at least in Chinese patients with CKD...
  4. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
    ....
  5. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
    ..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
  6. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
    ..01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value...
  7. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
    ..Statins reduce the incidence of cardiovascular events in patients at high cardiovascular risk. However, a benefit of statins in such patients who are undergoing hemodialysis has not been proved...
  8. ncbi Vitamin D levels and early mortality among incident hemodialysis patients
    M Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 72:1004-13. 2007
    ..Our study shows that among incident hemodialysis patients, vitamin D deficiency is common, correlates poorly with other components of mineral metabolism and is associated with increased early mortality...
  9. ncbi Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002
    ..The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain...
  10. ncbi Chronic kidney disease: the global challenge
    A Meguid El Nahas
    Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
    Lancet 365:331-40. 2005
    ..Consideration is given to health economics. A global and concerted approach to CKD must be adopted in both more and less developed countries to avoid a major catastrophe...
  11. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
    ..CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes...
  12. ncbi Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
    Kidney Int 63:793-808. 2003
    ..It is possible that new standards or goals for such traditional risk factors as body mass, serum cholesterol, and blood pressure should be considered for these individuals...
  13. ncbi International comparison of the relationship of chronic kidney disease prevalence and ESRD risk
    Stein I Hallan
    Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
    J Am Soc Nephrol 17:2275-84. 2006
    ..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway...
  14. ncbi Body mass index and risk for end-stage renal disease
    Chi yuan Hsu
    Division of Nephrology, University of California, San Francisco, San Francisco, California 94143 0532, USA
    Ann Intern Med 144:21-8. 2006
    ..Although interest in the relationship between obesity and kidney disease is increasing, few epidemiologic studies have examined whether excess weight is an independent risk factor for end-stage renal disease (ESRD)...
  15. ncbi Prevalence of kidney damage in Australian adults: The AusDiab kidney study
    Steven J Chadban
    Department of Nephrology, Monash Medical Centre, USA
    J Am Soc Nephrol 14:S131-8. 2003
    ..Identifying and targeting this section of the population may provide a means to reduce the burden of ESRD...
  16. ncbi End-stage renal disease in the United States: an update from the United States Renal Data System
    Robert N Foley
    United States Renal Data System, 914 South 8th Street, Suite S 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 18:2644-8. 2007
    ..7% of total Medicare expenditures...
  17. ncbi Vascular calcification mechanisms
    Cecilia M Giachelli
    Bioengineering Department, Box 351720, University of Washington, Okanogan Lane, Bagley Hall, Seattle, WA 98195, USA
    J Am Soc Nephrol 15:2959-64. 2004
    ..Whether or not vascular calcification can be reversed is not yet known, but exciting new studies suggest that this may be possible in the future...
  18. ncbi Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999
    Robert N Foley
    United States Renal Data System Coordinating Center, 914 South 8th Street, Suite D 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:489-95. 2005
    ..On an absolute basis, however, the high death rates of patients with CKD may reflect accelerated rates of atherosclerotic vascular disease and congestive heart failure...
  19. ncbi Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial
    Jackson T Wright
    Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
    JAMA 288:2421-31. 2002
    ..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
  20. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  21. ncbi Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin
    Steven Fishbane
    Winthrop University Hospital, Mineola, New York, USA
    Kidney Int 68:1337-43. 2005
    ..Therapy, however, is often observed to be associated with recurrent cyclic fluctuations in hemoglobin levels. The purpose of this analysis was to describe the phenomenology of hemoglobin cycling during rHuEPO treatment...
  22. ncbi Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy
    O Hotta
    Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan
    Am J Kidney Dis 38:736-43. 2001
    ..These findings indicate that interventions aimed at achieving clinical remission have provided encouraging results applicable to managing patients with IgA nephropathy...
  23. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  24. ncbi Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    Douglas S Keith
    Division of Nephrology and Hypertension, Oregon Health and Science University, USA
    Arch Intern Med 164:659-63. 2004
    ..The purpose of this study was to understand the natural history of chronic kidney disease with regard to progression to renal replacement therapy (transplant or dialysis) and death in a representative patient population...
  25. ncbi Proteinuria and the risk of developing end-stage renal disease
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of The Ryukyus and Okinawa General Health Maintenance Association, Okinawa, Japan
    Kidney Int 63:1468-74. 2003
    ..Dipstick urinalysis for proteinuria and hematuria has been used to screen renal disease, but evidence of the clinical impact of this test on development of end-stage renal disease (ESRD) is lacking...
  26. ncbi Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies
    Daniel E Weiner
    Division of Nephrology, Department of Clinical Care Research, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1307-15. 2004
    ..It is hypothesized that this effect may be due to more frequent or more severe subclinical vascular disease secondary to hypertension or diabetes in black individuals...
  27. pmc Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey
    Stein I Hallan
    Department of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7006 Trondheim, Norway
    BMJ 333:1047. 2006
    ..To find an effective screening strategy for detecting patients with chronic kidney disease and to describe the natural course of the disease...
  28. ncbi Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    Nephrol Dial Transplant 18:1731-40. 2003
    ..The aim of this study was to investigate the prognostic value of AMC in relationship to all-cause or CV mortality for stable haemodialysis (HD) patients...
  29. ncbi Cardiac diseases in maintenance hemodialysis patients: results of the HEMO Study
    Alfred K Cheung
    Veterans Affairs Salt Lake City Healthcare System and University of Utah, Salt Lake City, 84112, USA
    Kidney Int 65:2380-9. 2004
    ....
  30. ncbi Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States
    Chi yuan Hsu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Am Soc Nephrol 14:2902-7. 2003
    ..The key to understanding black-white differences in ESRD incidence lies in understanding the extreme differences in their progression from CRI to ESRD...
  31. pmc The emerging role of phosphate in vascular calcification
    Cecilia M Giachelli
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 75:890-7. 2009
    ..Disease states and cytokines can increase expression of sodium-dependent phosphate cotransporters in SMCs, thereby increasing susceptibility to calcification even at phosphate concentrations that are in the normal range...
  32. ncbi Comparing the risk for death with peritoneal dialysis and hemodialysis in a national cohort of patients with chronic kidney disease
    Bernard G Jaar
    Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Independent Dialysis Foundation, Baltimore, Maryland 21205, USA
    Ann Intern Med 143:174-83. 2005
    ..The influence of type of dialysis on survival of patients with end-stage renal disease (ESRD) is controversial...
  33. ncbi Maintenance dialysis population dynamics: current trends and long-term implications
    Michael J Lysaght
    Center for Biomedical Engineering, Brown University, Providence, Rhode Island 02818, USA
    J Am Soc Nephrol 13:S37-40. 2002
    ..The care of this group represents a major societal commitment: the aggregate cost of treating ESRD during the coming decade will exceed 1 trillion dollars, a thought-provoking sum by any economic metric...
  34. pmc Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry
    Andrea O Y Luk
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Diabetes Care 31:2357-61. 2008
    ..We examined risk associations of metabolic syndrome with new onset of chronic kidney disease (CKD) in 5,829 Chinese patients with type 2 diabetes enrolled between 1995 and 2005...
  35. ncbi Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data
    T H Jafar
    Department of Medicine, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    Ann Intern Med 135:73-87. 2001
    ..Angiotensin-converting inhibitors are indicated for treatment of nondiabetic patients with chronic renal disease and proteinuria and, possibly, those without proteinuria...
  36. ncbi Mortality caused by sepsis in patients with end-stage renal disease compared with the general population
    M J Sarnak
    Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 58:1758-64. 2000
    ..Although it is intuitive to believe that mortality caused by sepsis may be higher in patients with ESRD compared with the general population (GP), no such data are currently available...
  37. ncbi A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients
    Teresa Adragao
    Nefroclinica Estoril, Rua Vale de S Rita, 19, 2765 293 Esteril, Portugal
    Nephrol Dial Transplant 19:1480-8. 2004
    ....
  38. ncbi Nephrologist care and mortality in patients with chronic renal insufficiency
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:2002-6. 2002
    ..We sought to determine whether early or frequent access to nephrologist care prior to the initiation of dialysis was associated with a difference in mortality rates in the first year after dialysis began...
  39. ncbi Causes and consequences of chronic kidney disease: implications for managed health care
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston MA 02111, USA
    J Manag Care Pharm 13:S1-9. 2007
    ....
  40. ncbi The association among smoking, heavy drinking, and chronic kidney disease
    Anoop Shankar
    Department of Community, Occupational, and Family Medicine, Division of Epidemiology, National University of Singapore, Republic of Singapore
    Am J Epidemiol 164:263-71. 2006
    ..93, 95% CI: 2.45, 9.94). Smoking and consumption of four or more servings of alcohol per day are associated with CKD...
  41. ncbi CKD risk factors reported by primary care physicians: do guidelines make a difference?
    Janice P Lea
    Renal Division, Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Kidney Dis 47:72-7. 2006
    ....
  42. ncbi Body size and outcomes on peritoneal dialysis in the United States
    Jon J Snyder
    Nephrology Analytical Services, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    Kidney Int 64:1838-44. 2003
    ..Being overweight is often cited as a relative contraindication to peritoneal dialysis. Our primary objective was to determine whether actual mortality rates support this opinion...
  43. ncbi Mortality differences by dialysis modality among incident ESRD patients with and without coronary artery disease
    Santhi K Ganesh
    Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 14:415-24. 2003
    ..Whether differences in solute clearance and/or cardiac risk profiles between PD and HD may explain these findings deserves further investigation...
  44. ncbi The acute-phase response varies with time and predicts serum albumin levels in hemodialysis patients. The HEMO Study Group
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, 95616, USA
    Kidney Int 58:346-52. 2000
    ..The longitudinal relationship among laboratory measurements and how they vary over time in a population of patients are unknown...
  45. ncbi On the evolving nature of understanding dialysis-related disorders
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Kidney Dis 41:S1-3. 2003
  46. ncbi Epidemiology of chronic renal failure in children: data from the ItalKid project
    Gianluigi Ardissino
    Unit of Pediatric Nephrology, Dialysis and Transplantation, Department of Pediatrics, Milano, Italy
    Pediatrics 111:e382-7. 2003
    ..This article reports the epidemiologic results...
  47. ncbi Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Eric W Young
    University of Michigan Veterans Administration Medical Center, Ann Arbor, MI 48105, USA
    Am J Kidney Dis 44:34-8. 2004
    ..Mineral metabolism has emerged as an important predictor of morbidity and mortality in dialysis patients, independent of bone and muscle concerns. Several expert panels have issued management guidelines for mineral metabolism...
  48. pmc Vascular access use and outcomes: an international perspective from the Dialysis Outcomes and Practice Patterns Study
    Jean Ethier
    Department of Nephrology, Centre Hospitalier de l Université de Montéal, Montreal, Quebec, Canada
    Nephrol Dial Transplant 23:3219-26. 2008
    ..DOPPS is a prospective, observational study of haemodialysis (HD) practices and patient outcomes at >300 HD units from 12 countries and has collected data thus far from >35,000 randomly selected patients...
  49. ncbi Renal replacement therapy in Europe: the results of a collaborative effort by the ERA-EDTA registry and six national or regional registries
    P C van Dijk
    ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Nephrol Dial Transplant 16:1120-9. 2001
    ..The improvement in patient survival over the last two decades has been much greater in transplant recipients than in dialysis patients...
  50. ncbi COL4A3/COL4A4 mutations producing focal segmental glomerulosclerosis and renal failure in thin basement membrane nephropathy
    Konstantinos Voskarides
    Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
    J Am Soc Nephrol 18:3004-16. 2007
    ..The findings presented here do not justify the labelling of thin basement membrane nephropathy as a benign condition with excellent prognosis...
  51. ncbi Cost analysis of ongoing care of patients with end-stage renal disease: the impact of dialysis modality and dialysis access
    Helen Lee
    Department of Economics, University of Calgary, Alberta, Canada
    Am J Kidney Dis 40:611-22. 2002
    ..Care of patients with end-stage renal disease (ESRD) is important and resource intense. To enable ESRD programs to develop strategies for more cost-efficient care, an accurate estimate of the cost of caring for patients with ESRD is needed...
  52. ncbi Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia
    Nizar Attallah
    Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Kidney Dis 47:644-54. 2006
    ..We conducted an open-label prospective study to assess the effect of vitamin C, an antioxidant, on EPO-hyporesponsive anemia in hemodialysis patients with unexplained hyperferritinemia...
  53. ncbi Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: the USRDS waves 1, 3, and 4 study
    Yelena Slinin
    United States Renal Data System Coordinating Center, 914 South 8th Street, Suite D 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:1788-93. 2005
    ....
  54. ncbi Factors associated with health-related quality of life among hemodialysis patients in the DOPPS
    Antonio Alberto Lopes
    Department of Medicine, Federal University of Bahia, Salvador, Brazil
    Qual Life Res 16:545-57. 2007
    ..To identify modifiable factors associated with health-related quality of life (HRQOL) among chronic hemodialysis patients...
  55. ncbi Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compared to placebo and iron dextran
    Beckie Michael
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Kidney Int 61:1830-9. 2002
    ..S. under FDA's priority drug review. This Phase IV study was designed to evaluate the safety of a single dose of intravenous SFGC as compared to placebo and a historical iron dextran control...
  56. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
    ..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
  57. ncbi Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis
    J M Kaplan
    Renal and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 24:251-6. 2000
    ..Our results have implications for understanding the role of the cytoskeleton in the pathophysiology of kidney disease and may lead to a better understanding of the genetic basis of susceptibility to kidney damage...
  58. ncbi Vascular calcification and cardiovascular function in chronic kidney disease
    Mhairi Sigrist
    Department of Renal Medicine, Derby City General Hospital, Derby, DE22 3NE, UK
    Nephrol Dial Transplant 21:707-14. 2006
    ..Few data are currently available comparing vascular calcification and its attendant functional cardiovascular consequences between CKD stage 4 patients and both peritoneal dialysis (PD) and haemodialysis (HD) (CKD stage 5) patients...
  59. ncbi Is obesity a major cause of chronic kidney disease?
    John E Hall
    Department of Physiology and Biophysics and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, MS, USA
    Adv Ren Replace Ther 11:41-54. 2004
    ..Special considerations for the obese patient, in addition to adequately controlling the blood pressure, include correction of the metabolic abnormalities and protection of the kidneys from further injury...
  60. ncbi Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, London, UK
    Lancet 366:2026-33. 2005
    ..Guidelines specify that these are the drugs of choice for the treatment of hypertension in patients with renal disease. We sought to determine to what extent this consensus is supported by the available evidence...
  61. ncbi Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease
    Carmine Zoccali
    National Research Council Center of Clinical Physiology, Reggio Calabria, Italy
    J Am Soc Nephrol 13:134-41. 2002
    ..Furthermore, ADPN is related to several metabolic risk factors in a manner consistent with the hypothesis that this protein acts as a protective factor for the cardiovascular system...
  62. ncbi Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study
    Holly Kramer
    Loyola Medical Center, Department of Preventive Medicine, 2160 First Avenue, Maywood, IL 60153, USA
    J Am Soc Nephrol 16:507-13. 2005
    ..These findings need to be confirmed in study populations that include adults >65 yr of age and a larger number of CKD cases...
  63. ncbi Predictors of loss of residual renal function among new dialysis patients
    L M Moist
    Department of Medicine, University of Western Ontario, London, Canada
    J Am Soc Nephrol 11:556-64. 2000
    ..The observations of demographic groups at risk and potentially modifiable factors and therapies have generated testable hypotheses regarding therapies that may preserve RRF among end-stage renal disease patients...
  64. ncbi Arterial wave reflections and survival in end-stage renal failure
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, Ste Genevieve des Bois, France
    Hypertension 38:434-8. 2001
    ..16 to 1.90; P<0.0001) for CV mortality. These results provide the first direct evidence that in ESRF patients increased effect of arterial wave reflections is an independent predictor of all-cause and CV mortality...
  65. pmc Patient awareness of chronic kidney disease: trends and predictors
    Laura C Plantinga
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Arch Intern Med 168:2268-75. 2008
    ..The impact of recent guidelines for early detection and prevention of chronic kidney disease (CKD) on patient awareness of disease and factors that might be associated with awareness have not been well described...
  66. ncbi Impact of timing of nephrology referral and pre-ESRD care on mortality risk among new ESRD patients in the United States
    Austin G Stack
    Department of Internal Medicine, Division of Renal Diseases and Hypertension, University of Texas Medical School Houston, TX, 77030, USA
    Am J Kidney Dis 41:310-8. 2003
    ..We evaluated the impact of early nephrology referral and pre-end-stage renal disease (ESRD) care on mortality risk in a national cohort of new patients starting dialysis therapy in 1996 and 1997...
  67. ncbi Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE Study
    J Craig Longenecker
    Johns Hopkins University School of Medicine, Suite 2 637, 2024 E Monument Street, Baltimore, MD 21205, USA
    J Am Soc Nephrol 13:1918-27. 2002
    ..In summary, many ASCVD risk factors are more prevalent in ESRD than in the general population and may explain some, but probably not all, of the increased ASCVD risk in ESRD...
  68. ncbi Body mass index and mortality in 'healthier' as compared with 'sicker' haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    S F Leavey
    Division of Nephrology, University of Michigan and VAMC, Ann Arbor, USA
    Nephrol Dial Transplant 16:2386-94. 2001
    ..e. have better overall survival). We hypothesized that an increased mortality risk might be associated with high BMI in a variety of other 'healthier' subgroups of HD patients...
  69. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....
  70. ncbi Inflammation in end-stage renal disease: the hidden enemy
    Peter Stenvinkel
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Nephrology (Carlton) 11:36-41. 2006
    ..Elevated CRP in dialysis patients could be evaluated at three different levels: (i) national/regional level; (ii) dialysis unit level; and (iii) individual patient level...
  71. ncbi Insulin resistance in patients with chronic kidney disease
    Shuzo Kobayashi
    Department of Nephrology and Kidney and Dialysis Center, Shonan Kamakura General Hospital, Kamakura, Japan
    Am J Kidney Dis 45:275-80. 2005
    ..However, few data are available concerning what factors of metabolic abnormalities, such as apolipoprotein (Apo) profile or acidosis, might be associated with insulin resistance in patients with CKD...
  72. pmc African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
    Doron M Behar
    Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel
    Hum Mol Genet 19:1816-27. 2010
    ....
  73. ncbi Cardiovascular disease and mortality in ESRD
    R N Foley
    The Division of Nephrology, The Health Sciences Centre, Memorial University, St John s, Newfoundland, Canada
    J Nephrol 11:239-45. 1998
    ..Many risk factors act in concert to produce cardiovascular disease in ESRD. Many can be treated, suggesting that the huge burden of disease can be reduced considerably...
  74. ncbi Statins for improving renal outcomes: a meta-analysis
    Sabrina Sandhu
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2006-16. 2006
    ..17 to 0.98). Statin therapy seems to reduce proteinuria modestly and results in a small reduction in the rate of kidney function loss, especially in populations with cardiovascular disease...
  75. ncbi Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease
    Kayo Shinohara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Am Soc Nephrol 13:1894-900. 2002
    ..In contrast, HOMA-IR did not show such a significant association with noncardiovascular mortality. These results indicate that insulin resistance is an independent predictor of cardiovascular mortality in ESRD...
  76. ncbi Health-related quality of life and estimates of utility in chronic kidney disease
    Irina Gorodetskaya
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94118 1211, USA
    Kidney Int 68:2801-8. 2005
    ..Health-related quality of life and estimates of utility have been carefully evaluated in persons with end-stage renal disease. Fewer studies have examined these parameters in persons with chronic kidney disease (CKD)...
  77. ncbi Cardiovascular disease risk factors in chronic renal insufficiency
    M J Sarnak
    New England Medical Center, Boston, MA 02111, USA
    Clin Nephrol 57:327-35. 2002
    ..Coronary heart disease (CHD) is an important cause of morbidity and mortality in end-stage renal disease (ESRD). Prevention of CHD in ESRD requires identification and treatment of coronary risk factors in chronic renal insufficiency (CRI)...
  78. ncbi Inflammation is associated with carotid atherosclerosis in dialysis patients. Creed Investigators. Cardiovascular Risk Extended Evaluation in Dialysis Patients
    C Zoccali
    CNR Centro Fisiologia Clinica e Divisione di Nefrologia, Ospedali Riuniti, Reggio Cal, Italy
    J Hypertens 18:1207-13. 2000
    ..To investigate the relationship between inflammatory processes and atherosclerosis in uraemic patients on chronic dialysis...
  79. ncbi Type of vascular access and survival among incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study
    Brad C Astor
    Johns Hopkins Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, 2024 East Monument Street, Suite 2 600 Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 16:1449-55. 2005
    ....
  80. pmc Abdominal aortic calcification in dialysis patients: results of the CORD study
    Eero Honkanen
    Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Nephrol Dial Transplant 23:4009-15. 2008
    ..AAC may be recorded using plain radiographs. The present report is an analysis of baseline data on AAC in patients enrolled in the CORD (Calcification Outcome in Renal Disease) study...
  81. ncbi Sudden cardiac death and dialysis patients
    Charles A Herzog
    Cardiovascular Special Studies Center, United States Renal Data System, Minneapolis, Minnesota, USA
    Semin Dial 21:300-7. 2008
    ....
  82. ncbi C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 68:766-72. 2005
    ..There are limited data evaluating the relationships between CRP, albumin, and outcomes in chronic kidney disease (CKD) stages 3 and 4...
  83. ncbi Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United States
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and RLR VA Medical Center, Indianapolis 46202, USA
    Am J Med 115:291-7. 2003
    ..Hypertension is common in chronic hemodialysis patients, yet there are limited data on the epidemiology of hypertension in these patients in the United States...
  84. pmc Recombinant erythropoietin in clinical practice
    T Ng
    Phase One Clinical Trials Unit Ltd, Plymouth, UK
    Postgrad Med J 79:367-76. 2003
    ..Besides highlighting both the historical and functional aspects of RHuEPO, this review discusses the applications of RHuEPO in clinical practice and the potential problems of RHuEPO treatment...
  85. ncbi Cancer in end-stage renal disease: potential factors involved -editorial-
    S Vamvakas
    Institut fur Toxikologie, Universitat Wurzburg, Deutschland
    Am J Nephrol 18:89-95. 1998
    ....
  86. ncbi Validation of the KDQOL-SF: a dialysis-targeted health measure
    J C Korevaar
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
    Qual Life Res 11:437-47. 2002
    ..The aim of this study was to determine the basic psychometric properties, reliability and validity of the short form of the KDQOL i.e. the KDQOL-SF, a dialysis-targeted instrument, and to assess its ability to detect changes over time...
  87. ncbi Exercise in the end-stage renal disease population
    Kirsten L Johansen
    Nephrology Section, 111J, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 18:1845-54. 2007
    ....
  88. ncbi Exercise training in patients with end-stage renal disease on hemodialysis: comparison of three rehabilitation programs
    Erasmia Konstantinidou
    Laboratory of Sports Medicine, Renal Unit, Aristotle University of Thessaloniki, Greece
    J Rehabil Med 34:40-5. 2002
    ..These results demonstrate that intense exercise training on non-dialysis days is the most effective way of training, whereas exercise during HD is also effective and preferable...
  89. ncbi Predicting initiation and progression of chronic kidney disease: Developing renal risk scores
    M W Taal
    Department of Renal Medicine, Derby Hospitals NHS Foundation Trust and Centre for Integrated Systems in Biology and Medicine, University of Nottingham, Derby City General Hospital, Derby, UK
    Kidney Int 70:1694-705. 2006
    ....
  90. ncbi Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis
    Arintaya Phrommintikul
    NHMRC Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Australia
    Lancet 369:381-8. 2007
    ..Our aim was to determine whether targeting different haemoglobin concentrations with such treatment is associated with altered all-cause mortality and cardiovascular events in patients with anaemia caused by chronic kidney disease...
  91. ncbi A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa
    T M Han
    Department of Nephrology, Division of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Kidney Int 69:2243-50. 2006
    ..This will allow diagnosis and treatment of HIVAN at an early stage and may prevent further disease progression...
  92. pmc Failure of ICD-9-CM codes to identify patients with comorbid chronic kidney disease in diabetes
    Elizabeth F O Kern
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Department of Medicine, Cleveland, OH 44106 4951, USA
    Health Serv Res 41:564-80. 2006
    ..To determine prevalence of chronic kidney disease (CKD) in patients with diabetes, and accuracy of International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes to identify such patients...
  93. ncbi Hemodialysis clinical practice guidelines for the Canadian Society of Nephrology
    Kailash Jindal
    J Am Soc Nephrol 17:S1-27. 2006
  94. ncbi National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification
    Ronald J Hogg
    North Texas Hospital for Children and the Department of Clinical Research at Medical City Dallas Hospital, Dallas, Texas 75230, USA
    Pediatrics 111:1416-21. 2003
    ....
  95. ncbi Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial
    Bruce F Culleton
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 298:1291-9. 2007
    ..Morbidity and mortality rates in hemodialysis patients remain excessive. Alterations in the delivery of dialysis may lead to improved patient outcomes...
  96. ncbi Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, Minn 55415, USA
    Circulation 106:2941-5. 2002
    ..This study determined the prevalence of increased cardiac troponin I (cTnI) and T (cTnT) in end-stage renal disease (ESRD) patients and whether an increased troponin was predictive of death...
  97. ncbi Body mass index and the risk of development of end-stage renal disease in a screened cohort
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Kidney Int 65:1870-6. 2004
    ..However, few studies have examined the significance of body mass index (BMI) as a risk factor for the development of ESRD in the general population...
  98. ncbi Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?
    Thomas Grobner
    Department of Nephrology, General Hopsital of Wiener Neustadt, A 2700 Wiener Neustadt, Austria
    Nephrol Dial Transplant 21:1104-8. 2006
  99. ncbi Medication prescribing patterns in ambulatory haemodialysis patients: comparisons of USRDS to a large not-for-profit dialysis provider
    Harold J Manley
    University of Missouri, Kansas City, Kansas City School of Pharmacy, Kansas City, MI 64108, USA
    Nephrol Dial Transplant 19:1842-8. 2004
    ..The objective was to analyse and compare haemodialysis (HD) patient medication prescribing patterns between the Dialysis Clinic, Inc. (DCI) database and the USRDS report...
  100. ncbi Mortality in end-stage renal disease: a reassessment of differences between patients treated with hemodialysis and peritoneal dialysis
    E F Vonesh
    Baxter Healthcare Corporation, Applied Statistics Center, Round Lake, Illinois 60073, USA
    J Am Soc Nephrol 10:354-65. 1999
    ..Additional incident-based studies that allow for additional case-mix adjustments are needed to better compare outcomes between HD and PD...
  101. ncbi Determinants of type and timing of initial permanent hemodialysis vascular access
    C O Stehman-Breen
    Department of Surgery, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA
    Kidney Int 57:639-45. 2000
    ..We undertook a population-based study of hemodialysis (HD) patients to determine which factors are important in predicting the type of permanent access initially placed and if a functional permanent access is in place at the start of HD...

Research Grants64

  1. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ....
  2. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ....
  3. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ....
  4. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..No specific treatment currently exists. This proposal will test the feasibility of treating these disorders using a new technology, microRNA-based therapeutics. ..
  5. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ....
  6. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2013
    ..The goal of the proposal is to define the mechanisms that are involved during kidney injury and to utilize inhibitors that antagonize against the offending agent(s) responsible for disease progression. ..
  7. Mechanisms of cLDL-Induced Endothelial Injury
    Sudhir V Shah; Fiscal Year: 2013
    ..In addition, we have demonstrated that elevated plasma cLDL concentration from either chronic kidney failure or chronic urea consumption results in the development of aortic atherosclerosis in mice...
  8. Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study
    Clifford E Kashtan; Fiscal Year: 2013
    ..We hope that the approaches we develop will be of relevance to investigators studying other unusual genetic renal disorders. ..
  9. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..We are hopeful that omega-3 fatty acid supplements may add to current therapies that help protect against progression of kidney disease, a common and devastating complication of diabetes. ..
  10. The exocyst in ciliogenesis and cystogenesis
    Joshua H Lipschutz; Fiscal Year: 2013
    ..Here, we propose experiments to test how the exocyst builds primary cilia, with successful completion leading to identification of novel candidate targets for intervention in ADPKD. ..
  11. Sun protection Internet-based program for kidney transplant recipients
    June K Robinson; Fiscal Year: 2013
    ....
  12. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2013
    ..abstract_text> ..
  13. Identification of a Multi-Analyte Profile for Primary Hyperoxaluria
    James P Mapes; Fiscal Year: 2012
    ..abstract_text> ..
  14. Molecular Mechanisms of Albumin Trafficking in Podocytes
    Judith T Blaine; Fiscal Year: 2013
    ....
  15. RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASE
    Gary V Desir; Fiscal Year: 2010
    ..Renalase itself or components of the renalase pathway may offer valuable therapeutic options for patients with kidney disease. ..
  16. Immune Dysregulation in Uremia
    Neal B Blatt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic kidney failure, also known as end-stage renal disease (ESRD), results in the build-up of waste toxins that affect organs and tissues throughout the body, and causes significant mortality...
  17. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El-Dahr; Fiscal Year: 2012
    ..Abnormalities of kidney development (i.e., congenital malformations) account for up to 40% of cases of chronic kidney failure in infants and children requiring dialysis and transplantation...
  18. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Congenital malformations of the kidney and urinary tract account for up to 40% of chronic kidney failure in children less than 4 years of age...
  19. Role of Par1 Polarity Proteins in Podocyte Development and Glomerular Disease
    KIMBERLY JEAN REIDY; Fiscal Year: 2013
    ....
  20. The Role of the Calcium Activated Potassium Channel, KCa3.1, in the Pathogenesis
    Edward Skolnik; Fiscal Year: 2010
    ..1) already exists and are in human trials without any major side effects. Thus, if inhibiting this channel shows promise in mouse models of ADPKD, we can rapidly move into the clinic to assess treatment in patients. ..
  21. The role of DNA damage response signaling in chronic kidney disease
    Rannar Airik; Fiscal Year: 2013
    ..The BCH/HMS has several collaborative research groups working on kidney development and diseases providing an ideal environment for my training and career development. ..
  22. Novel Urinary Proteomic Biomarkers for Acute Renal Transplant Rejection
    Minnie M Sarwal; Fiscal Year: 2010
    ..In this study, we propose to utilize two most powerful proteomic techniques to identify non-invasive proteomic biomarkers for acute rejection. ..
  23. Mineral metabolism disturbances and arteriovenous fistula maturation
    Bryan R Kestenbaum; Fiscal Year: 2013
    ....
  24. Urinary Proteome Monitoring for Transplant Injury
    Minnie M Sarwal; Fiscal Year: 2013
    ..We are going to use two most powerful proteomic methods to identify these biomarkers which will be first of its kind in the field of transplantation. ..
  25. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA'AYAN; Fiscal Year: 2013
    ....
  26. Identifying urinary biomarkers for early type 2 diabetic nephropathy
    Maryam Afkarian; Fiscal Year: 2013
    ..We plan to find urine marker proteins that can be used to detect early signs of diabetic damage to the kidneys, when it is more likely to be stopped or reversed. ..
  27. Cell Cycle and Podocytes
    STUART JAMES SHANKLAND; Fiscal Year: 2013
    ..Our published work shows that studying podo has the added advantage that discoveries in cell cycle can be broadly applied to other terminally differentiated cells, which helps drive discovery in the field. ..
  28. Redefining membranous nephropathy by autoantibody-specific subclassification
    Laurence H Beck; Fiscal Year: 2013
    ....
  29. Prognostic Biomarkers to Predict Progression of Pediatric Chronic Kidney Disease
    ELLEN ROSE BROOKS; Fiscal Year: 2013
    ..If successful, we will provide a better understanding of the role of MADs in pediatric CKD and provide rational screening strategies to test new hypotheses about changing rates of CKD progression or CV disease burden in future studies. ..
  30. ADENOSINE AND RENAL INJURY
    MARK OKUSA; Fiscal Year: 2009
    ..These experiments also will shed light on the role of inflammation in the etiology of DN and provide insights into other potential anti-inflammatory therapeutic strategies. ..
  31. Chronic Kidney Disease Knowledge and Awareness among American Indians
    Stacey Jolly; Fiscal Year: 2013
    ..In summary, with this K23 award, Dr. Jolly will be able to focus the majority of her time and effort on career development and research to acquire the advanced training and receive the critical mentorship needed. ..
  32. A Pilot Study Validating Novel Algorithm for Kidney Disease
    Abhijit V Kshirsagar; Fiscal Year: 2010
    ....
  33. CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve
    Sudhir V Shah; Fiscal Year: 2011
    ..the development of aortic atherosclerosis in mice that have elevated plasma cLDL due either to chronic kidney failure or chronic urea consumption...
  34. Uncovering CD36-mediated oxidative and inflammatory pathways in progressive renal
    DARYL MIYOSHI OKAMURA; Fiscal Year: 2010
    ..Our studies on the cellular receptor CD36 and its ligand oxidized lipoprotein will shed new light in the progression of chronic kidney failure with hopes of developing new innovative therapies to alter its natural progression.
  35. IDENTIFICATION OF VUR GENES BY COMBINED LINKAGE ANALYSIS AND EXOME SEQUENCING
    RASHEED ADEBAYO GBADEGESIN; Fiscal Year: 2013
    ....
  36. Novel Biomarkers in Interstitial Fibrosis/Tubular Atrophy in Kidney Transplants
    SANJEEV KUMAR AKKINA; Fiscal Year: 2013
    ..RELEVANCE: The results of this study will provide further insight into IF/TA and provide biomarkers that may assist clinicians in treating a growing problem in kidney transplantation. ..
  37. Outcomes/Costs Related to Frequency of Physician-Patient Visits on Hemodialysis
    Areef Ishani; Fiscal Year: 2012
    ..Should the trial verify these findings, the current CMS policy should be revised, potentially leading to significant cost savings. ..
  38. Natriuretic Mechanisms Uderlying Spontaneous Hypertension
    Shetal H Padia; Fiscal Year: 2012
    ..Identification of these defects are essential to our understanding of the pathogenesis of essential hypertension in humans. ..
  39. The Role of Endocytosis and Actin Regulation in Podocytes
    Shuta Ishibe; Fiscal Year: 2013
    ..By completing these aims, we will have an opportunity to further expand our knowledge of endocytic pathways vital for podocyte homeostasis. ..
  40. A New Locus for Hereditary FSGS on Chromosome 2p
    RASHEED ADEBAYO GBADEGESIN; Fiscal Year: 2013
    ....
  41. Improving Kidney Transplant Outcomes Using Novel B-cell Immune Profiling
    Julie M Yabu; Fiscal Year: 2013
    ..Yabu's training. The planned research will form the basis for prospective studies using anti-B-cell therapies in sensitized kidney transplant recipients to be proposed in an R01 application before the end of the K23 award period. ..
  42. Mitochondrial Injury in the Anemia of Chronic Kidney Disease
    Madhumathi Rao; Fiscal Year: 2010
    ..The results of this proposal will provide new insight into the pathogenesis of anemia in patients with CKD with scope for novel therapeutic strategies. ..
  43. Mechanisms of Increased Ambulatory Blood Pressure in Intradialytic Hypertension
    Peter Noel Van Buren; Fiscal Year: 2013
    ....
  44. RESEARCH TRAINING IN RENAL DISEASE
    STUART JAMES SHANKLAND; Fiscal Year: 2012
    ..It is our expectation that continuing our success in developing the next generation of physician-scientists will insure a vigorous pipeline for delivering novel therapeutics to patients with kidney disease. ..
  45. The Alport Syndrome Symposium for Physicians, Researchers and Families
    Clifford E Kashtan; Fiscal Year: 2010
    ....
  46. Renal senescence in kidney donors
    Jane C Tan; Fiscal Year: 2013
    ..A central question in chronic kidney disease will shift toward the care of the elderly. My goal is to determined evidence-based guideline for selection of elderly individuals for safe transplantation and donation. ..
  47. Discovery &Validation of Biomarkers of Kidney Pathology
    Brad H Rovin; Fiscal Year: 2013
    ....
  48. Kidney Progenitor Cells in Disease
    STUART JAMES SHANKLAND; Fiscal Year: 2012
    ..The investigators will determine how important these progenitors are in regeneration after kidney damage. ..
  49. The Role of microRNA in Congenital Obstructive Nephropathy
    SUSAN ELIZABETH INGRAHAM; Fiscal Year: 2013
    ..Specific Aim 3 explores the potential of miRNA-targeted therapeutics in the mgb mouse model of congenital obstructive nephropathy. ..
  50. GDPrime
    BRUCE MARSHALL ROBINSON; Fiscal Year: 2013
    ..abstract_text> ..
  51. Pediatric Nephrology Training Program
    Sangeeta Hingorani; Fiscal Year: 2013
    ....
  52. The New York CKD Biomarker Discovery Program
    Erwin P Bottinger; Fiscal Year: 2013
    ..Thus, discovery of 'predictive'biomarkers for CKD progression is an important unmet need and the goal of the proposed New York CKD Biomarker Discovery Program. ..
  53. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    ..After the Contrast Extraction Monitor is approved for clinical use, it will provide essential information about the amount of contrast removed from the patient, which is pivotal to a successful outcome. ..
  54. Mapping Multidimensional Illness Trajectories of Patients With ESKD
    Mi Kyung Song; Fiscal Year: 2013
    ..This study will provide data to help identify and meet the complex needs of patients with ESKD who experience acute life-threatening events superimposed on the demands of dialysis and co-morbidities. ..
  55. AOSSM Post-joint Injury Conference II
    Scott A Rodeo; Fiscal Year: 2010
    ....
  56. The Role of BMP-7 in Chronic Kidney Disease
    Keith Hruska; Fiscal Year: 2005
    ..A second hypothesis to be tested is that replacement of BMP-7 in chronic kidney failure will maintain bone remodeling rates in the absence of secondary hyperparathyroidism...
  57. The Hexosamine Pathway and Diabetic Nephropathy
    Leighton James; Fiscal Year: 2005
    ..These studies should further our understanding of the role of the hexosamine pathway in diabetic nephropathy, and may also provide a new animal model, in which to study diabetic nephropathy and its associated vascular complications...
  58. The Molecular Physiology of Renalase
    Gary V Desir; Fiscal Year: 2010
    ..Renalase itself or components of the renalase pathway may offer valuable therapeutic options for patients with kidney disease. ..
  59. PODOCYTURIA IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    DAVID KURNIT; Fiscal Year: 2005
    ..Once fully developed, this non-invasive tool will provide the clinician important information on the severity of disease, response to treatment, and nature of the podocyte injury. ..
  60. Mouse Model of X-Linked Alport Syndrome
    Yoav Segal; Fiscal Year: 2003
    ..abstract_text> ..
  61. Gene therapy treatment for severe anemia
    David Lewis; Fiscal Year: 2002
    ..abstract_text> ..
  62. A NOVEL APPROACH TO PREVENT ARTERIOVENOUS ACCESS FAILURE IN HEMODIALYSIS PATIENTS
    Eric T Choi; Fiscal Year: 2010
    ....
  63. Gene therapy treatment for severe anemia
    MAGDOLNA SEBESTYEN; Fiscal Year: 2006
    ..This Phase II project will use this simple and safe gene delivery approach and will combine it with an innovative way to control EPO expression in order to develop a regulatable gene therapy protocol for the treatment of severe anemia. ..
  64. Team Approach to Translate Novel Biomarkers for Diabetes
    Randall Nelson; Fiscal Year: 2009
    ....