pyelonephritis

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Top Publications

  1. ncbi Clinical differentiation of acute pyelonephritis from lower urinary tract infection in children
    Daniel Tsung Ning Huang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 40:513-7. 2007
  2. ncbi International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases
    Kalpana Gupta
    Department of Medicine, Veterans Affairs Boston Health Care System, Boston University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 52:e103-20. 2011
  3. ncbi Emphysematous pyelonephritis: clinicoradiological classification, management, prognosis, and pathogenesis
    J J Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China
    Arch Intern Med 160:797-805. 2000
  4. pmc Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein
    James A Roberts
    Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    J Urol 171:1682-5. 2004
  5. ncbi Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial
    Marco Pennesi
    Clinica Pediatrica, Istituto per l Infanzia IRCCS Burlo Garofolo, Via dell Istria 65 1, 34100 Trieste, Italy
    Pediatrics 121:e1489-94. 2008
  6. ncbi Molecular epidemiology of uropathogenic Escherichia coli
    Shingo Yamamoto
    The Department of Urology, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo 663 8501, Japan
    J Infect Chemother 13:68-73. 2007
  7. ncbi Caffeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats
    Sefa Celik
    Department of Biochemistry, Faculty of Veterinary Medicine, Mustafa Kemal University, Tayfur Sokmen Campus, Antakya, Hatay, 31034, Turkey
    Mol Cell Biochem 297:131-8. 2007
  8. ncbi Predictive factors for mortality and need for nephrectomy in patients with emphysematous pyelonephritis
    Rakesh Kapoor
    Sanjay Gandhi Post Graduate Institute, Lucknow, India
    BJU Int 105:986-9. 2010
  9. pmc Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice
    O Hertting
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska Hospital, Stockholm, Sweden
    Clin Exp Immunol 131:225-33. 2003
  10. ncbi Current management of emphysematous pyelonephritis
    Alan R Pontin
    Division of Urology, Groote Schuur Hospital, Anzio Road, Observatory 7925, Cape Town, South Africa
    Nat Rev Urol 6:272-9. 2009

Detail Information

Publications317 found, 100 shown here

  1. ncbi Clinical differentiation of acute pyelonephritis from lower urinary tract infection in children
    Daniel Tsung Ning Huang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 40:513-7. 2007
    To evaluate clinical variables for diagnosing childhood acute pyelonephritis (APN) when technetium-99m dimercaptosuccinic acid (DMSA) scintigraphy is not available.
  2. ncbi International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases
    Kalpana Gupta
    Department of Medicine, Veterans Affairs Boston Health Care System, Boston University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 52:e103-20. 2011
    ..The focus of this work is treatment of women with acute uncomplicated cystitis and pyelonephritis, diagnoses limited in these guidelines to premenopausal, non-pregnant women with no known urological ..
  3. ncbi Emphysematous pyelonephritis: clinicoradiological classification, management, prognosis, and pathogenesis
    J J Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China
    Arch Intern Med 160:797-805. 2000
    Emphysematous pyelonephritis (EPN) is a rare, severe gas-forming infection of renal parenchyma and its surrounding areas...
  4. pmc Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein
    James A Roberts
    Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    J Urol 171:1682-5. 2004
    A critical early step in the establishment of Escherichia coli pyelonephritis is bacterial attachment via the tip protein of P fimbriae. This adhesin, PapG, binds to glycolipid receptors present on vaginal and kidney epithelial surfaces...
  5. ncbi Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial
    Marco Pennesi
    Clinica Pediatrica, Istituto per l Infanzia IRCCS Burlo Garofolo, Via dell Istria 65 1, 34100 Trieste, Italy
    Pediatrics 121:e1489-94. 2008
    ..trials are still needed to determine the effectiveness of long-term antibiotics for the prevention of acute pyelonephritis. In this multicenter, open-label, randomized, controlled trial, we tested the effectiveness of antibiotic ..
  6. ncbi Molecular epidemiology of uropathogenic Escherichia coli
    Shingo Yamamoto
    The Department of Urology, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo 663 8501, Japan
    J Infect Chemother 13:68-73. 2007
    ..Uropathogenic VFs not only play an important role individually but also work cooperatively in a fine-tuned manner with coordinated regulation and expression...
  7. ncbi Caffeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats
    Sefa Celik
    Department of Biochemistry, Faculty of Veterinary Medicine, Mustafa Kemal University, Tayfur Sokmen Campus, Antakya, Hatay, 31034, Turkey
    Mol Cell Biochem 297:131-8. 2007
    ..that reason, we aimed to investigate the efficiency of CAPE administration in preventing oxidative damage in pyelonephritis (PYN) caused by Escherichia coli...
  8. ncbi Predictive factors for mortality and need for nephrectomy in patients with emphysematous pyelonephritis
    Rakesh Kapoor
    Sanjay Gandhi Post Graduate Institute, Lucknow, India
    BJU Int 105:986-9. 2010
    To analyse the factors predicting the mortality and need for nephrectomy in patients with emphysematous pyelonephritis (EPN).
  9. pmc Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice
    O Hertting
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska Hospital, Stockholm, Sweden
    Clin Exp Immunol 131:225-33. 2003
    ..and secretion of MIP-2, the mouse equivalent to human IL-8, MCP-1 and RANTES in the kidneys of mice with acute pyelonephritis. Female Bki NMRI, as well as IL-1beta deficient mice and their wild-type littermates, were transurethrally ..
  10. ncbi Current management of emphysematous pyelonephritis
    Alan R Pontin
    Division of Urology, Groote Schuur Hospital, Anzio Road, Observatory 7925, Cape Town, South Africa
    Nat Rev Urol 6:272-9. 2009
    Emphysematous pyelonephritis (EPN) is a severe, necrotizing renal parenchymal infection that is characterized by the production of intraparenchymal gas...
  11. pmc Kidney dendritic cells induce innate immunity against bacterial pyelonephritis
    André P Tittel
    Institutes of Molecular Medicine and Experimental Immunology IMMEI, Rheinische Friedrich Wilhelms Universita t, Bonn, Germany
    J Am Soc Nephrol 22:1435-41. 2011
    ..in the tubulointerstitium, suggesting that they may play an important role in interstitial infections such as pyelonephritis. Here, we optimized a murine pyelonephritis model by instilling uropathogenic Escherichia coli two times at a ..
  12. ncbi Neutrophil recruitment and resistance to urinary tract infection
    M Haraoka
    Institute of Laboratory Medicine, Section of Microbiology, Lund University, Sweden
    J Infect Dis 180:1220-9. 1999
    ..The results show that neutrophils are essential for bacterial clearance from the urinary tract and that the neutrophil recruitment deficiency in C3H/HeJ mice explains their susceptibility to gram-negative UTI...
  13. ncbi Prevalence and risk factor analysis of trimethoprim-sulfamethoxazole- and fluoroquinolone-resistant Escherichia coli infection among emergency department patients with pyelonephritis
    David A Talan
    Department of Emergency Medicine, Olive View UCLA Medical Center, 14445 Olive View Dr, North Annex, Sylmar, CA 91342, USA
    Clin Infect Dis 47:1150-8. 2008
    ..High rates of resistance to trimethoprim-sulfamethoxazole (TMP-SMX) among uropathogenic Escherichia coli are recognized, and concerns exist about emerging fluoroquinolone resistance...
  14. ncbi Relationship between acute pyelonephritis, renal scarring, and vesicoureteral reflux. Results of a coordinated research project
    Pilar Orellana
    Nuclear Medicine Section, School of Medicine, Catholic University of Chile, Marcoleta 347, Santiago, Chile
    Pediatr Nephrol 19:1122-6. 2004
    Acute pyelonephritis (APN) may produce permanent renal damage (PRD), which can subsequently lead to diverse complications. We prospectively evaluated 147 females and 122 males (mean age 3...
  15. ncbi A double-blind, randomized comparison of levofloxacin 750 mg once-daily for five days with ciprofloxacin 400/500 mg twice-daily for 10 days for the treatment of complicated urinary tract infections and acute pyelonephritis
    Janet Peterson
    Ortho McNeil Janssen Scientific Affairs, LLC, Raritan, New Jersey 08869, USA
    Urology 71:17-22. 2008
    ..study was conducted to compare the efficacy and safety of levofloxacin 750 mg once daily for 5 days to ciprofloxacin twice daily for 10 days for the treatment of complicated urinary tract infections (cUTI) or acute pyelonephritis (AP).
  16. ncbi Imaging studies after a first febrile urinary tract infection in young children
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh 15213 2583, USA
    N Engl J Med 348:195-202. 2003
    ..We investigated whether imaging studies altered management or improved outcomes in young children with a first febrile urinary tract infection...
  17. pmc Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli
    Alex Smithson
    Infectious Diseases Unit, Hospital Clinic, IDIBAPS, Edificio Helios, 1 Planta C Villarroel 170, 08036 Barcelona, Spain
    Clin Vaccine Immunol 14:256-61. 2007
    ..between polymorphisms of the MBL2 gene and the incidence of septic shock and bacteremia in patients with acute pyelonephritis due to Escherichia coli. The study included 62 female patients with acute pyelonephritis due to E...
  18. pmc SoxS increases the expression of the zinc uptake system ZnuACB in an Escherichia coli murine pyelonephritis model
    Douglas M Warner
    Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Bacteriol 194:1177-85. 2012
    ..coli clinical isolate prevents persistence beyond 2 days postinfection in a mouse model of pyelonephritis. We used microarray analysis to identify 242 genes differentially expressed between the triple deletion mutant ..
  19. ncbi Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
    Prashant S Patole
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Kidney Int 68:2582-7. 2005
    The molecular mechanisms of pathogen recognition that initiate infective pyelonephritis are poorly understood...
  20. ncbi Comparative study of Escherichia coli virulence determinants in strains causing urinary tract bacteremia versus strains causing pyelonephritis and other sources of bacteremia
    Eva Moreno
    Microbiology Department, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain
    Diagn Microbiol Infect Dis 53:93-9. 2005
    ..urinary bacteremia, 50 strains isolated from this condition were compared with 50 strains isolated from pyelonephritis and 50 from other sources of bacteremia...
  21. ncbi Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis
    Ji Nan Sheu
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Cytokine 36:276-82. 2006
    ..This prospective study investigated the association between serum and urine IL-6 and IL-8 levels and acute pyelonephritis confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) scan...
  22. ncbi Intestinal carriage of P fimbriated Escherichia coli and the susceptibility to urinary tract infection in young children
    K Plos
    Department of Clinical Immunology, , Sweden
    J Infect Dis 171:625-31. 1995
    ..These results suggest that persons who develop UTI have an increased tendency to carry pap+ E. coli in the large intestine and that these pap+ E. coli cause UTI more often than pap E. coli strains in the fecal flora of the same host...
  23. ncbi Ciprofloxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial
    Torsten Sandberg
    Department of Infectious Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    Lancet 380:484-90. 2012
    Acute pyelonephritis is a common infection in adult women, but there is a paucity of controlled trials of its treatment and the optimum duration of antibiotic treatment has not been properly defined...
  24. ncbi Assessment of Toll-like receptor-4 gene polymorphism on pyelonephritis and renal scar
    I Akil
    Department of Pediatric Nephrology, Celal Bayar University, Izmir, Turkey
    Int J Immunogenet 39:303-7. 2012
    ..5% in the UTI group and in 15.1% of the control group. Forty patients showed pyelonephritis (PN) with scar tissue, 37 patients had PN without scars, and 35 patients had lower UTI. The TLR4 c...
  25. ncbi Uropathogenic Escherichia coli AL511 requires flagellum to enter renal collecting duct cells
    Christophe Pichon
    Institut Pasteur, Unité Pathogénie Bactérienne des Muqueuses, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Cell Microbiol 11:616-28. 2009
    ..We investigated the ability of 13 E. coli strains isolated from the urine of patients with pyelonephritis and cystitis and normal stools to invade collecting duct cells, which constitute the first epithelium ..
  26. pmc Comparison of Escherichia coli strains recovered from human cystitis and pyelonephritis infections in transurethrally challenged mice
    D E Johnson
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 66:3059-65. 1998
    ..A vast amount of literature regarding the mechanisms through which E. coli induces pyelonephritis has accumulated...
  27. ncbi Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis
    Aydin Yagmurlu
    Department of Pediatric Surgery, University of Ankara School of Medicine, Ankara, Turkey
    Urology 61:1037-41. 2003
    To evaluate the efficiency of pentoxifylline (PTX), a methyl xanthine derivative, in preventing renal scar formation after the induction of pyelonephritis in an experimental rat model with delayed antimicrobial therapy.
  28. ncbi The effect of vitamin A on renal damage following acute pyelonephritis in children
    Parviz Ayazi
    Department of Pediatric Infectious Diseases, Clinical Research Center, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
    Eur J Pediatr 170:347-50. 2011
    ..study was to determine the effect of vitamin A on the rate of permanent renal damage in children with acute pyelonephritis. Fifty children, median age of 24 months (range 2-144), with first-time pyelonephritis verified by an uptake ..
  29. ncbi Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study
    Eduardo H Garin
    Department of Pediatrics, University of South Florida, Tampa, Florida, USA
    Pediatrics 117:626-32. 2006
    ..and severity of urinary tract infections (UTIs) and renal parenchymal damage among patients with acute pyelonephritis and to determine whether urinary antibiotic prophylaxis reduces the frequency and/or severity of UTIs and/or ..
  30. ncbi Genetic polymorphisms and susceptibility to parenchymal renal infection among pediatric patients
    Chi Hui Cheng
    Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 30:309-14. 2011
    ..This study was performed to explore single nucleotide polymorphisms (SNPs) in genes associated with neutrophil-dependent immunity in pediatric patients with severe parenchymal infections...
  31. pmc Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Am J Trop Med Hyg 83:1322-9. 2010
    Limited microbiology services impede adequate diagnosis and treatment of common infections such as pyelonephritis in resource-limited settings...
  32. ncbi Urinary interleukin-8 in acute pyelonephritis of children: a before-after study
    Masoumeh Mohkam
    Pediatric Infectious Research Center, Shahid Beheshti University MC, Tehran, Iran
    Iran J Kidney Dis 2:193-6. 2008
    The aim of this study was to assess urinary interleukin-8 (IL-8) levels in pyelonephritis and its relation with the clinical course of the infection and of inflammatory changes detected by renal scintigraphy.
  33. ncbi Risk factors for renal scar formation in infants with first episode of acute pyelonephritis: a prospective clinical study
    Yoon Jung Lee
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Urol 187:1032-6. 2012
    We prospectively determined the risk factors for renal scar formation after the first episode of acute pyelonephritis as confirmed on dimercapto-succinic acid scintigraphy in children younger than 1 year.
  34. ncbi Melatonin prevents neutrophil-mediated oxidative injury in Escherichia coli-induced pyelonephritis in rats
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    J Pineal Res 41:220-7. 2006
    Regarding the mechanisms of renal scarring in pyelonephritis, several hypotheses have been put forward, among which oxidative stress is prominent...
  35. pmc Evaluation of inflammatory and renal-injury markers in women treated with antibiotics for acute pyelonephritis caused by Escherichia coli
    Juan P Horcajada
    Service of Infectious Diseases, Institut Clinic Infeccions i Immunologia, Hospital Clinic Universitari IDIBAPS, Barcelona, Spain
    Clin Diagn Lab Immunol 11:142-6. 2004
    ..evolution and the relationship between inflammatory and renal-injury markers in women with acute uncomplicated pyelonephritis under antimicrobial therapy were investigated in a prospective study...
  36. pmc Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection
    Hans Fischer
    Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden
    PLoS Pathog 6:e1001109. 2010
    ..Host susceptibility to common infections like UTI may thus be strongly influenced by single gene modifications affecting the innate immune response...
  37. ncbi Emphysematous pyelonephritis: a case report series of four patients with review of literature
    N Mohsin
    Department of Nephrology, Royal Hospital, Muscat, Oman
    Ren Fail 31:597-601. 2009
    Emphysematous pyelonephritis (EPN) is an acute necrotizing infection with gas presence in the kidney, perinephric space, and/or urinary collecting system that carries a bad prognosis...
  38. ncbi Color and power Doppler sonography versus DMSA scintigraphy in acute pyelonephritis and in prediction of renal scarring
    Anne Hitzel
    Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France
    J Nucl Med 43:27-32. 2002
    Capabilities of color and power Doppler sonography (DS) were prospectively evaluated for diagnosis of acute pyelonephritis and for prediction of scarring by comparison with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA).
  39. ncbi Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis
    Metin Kaya Gurgoze
    Department of Pediatrics, Firat University Faculty of Medicine, Elazig, Turkey
    Pediatr Nephrol 20:1445-8. 2005
    ..of procalcitonin (PCT) and proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) in children with acute pyelonephritis documented by dimercaptosuccinic acid scintigraphy (DMSA)...
  40. pmc Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece
    Antimicrob Agents Chemother 48:93-9. 2004
    ..Acute pyelonephritis was induced after ligation of the right ureter and injection of 10(8) CFU of the test isolate per kg of body ..
  41. ncbi [Usefulness of procalcitonin for the diagnosis of acute pyelonephritis in children]
    S Bigot
    Clinique de Pediatrie, Hopital Jeanne de Flandre, Lille, France
    Arch Pediatr 12:1075-80. 2005
    Acute pyelonephritis can induce parenchymal scarring. The aim of this study was to evaluate the usefulness of procalcitonin (PCT) to predict renal involvement in febrile children with urinary tract infection (UTI).
  42. ncbi A disseminated multidrug-resistant clonal group of uropathogenic Escherichia coli in pyelonephritis
    James R Johnson
    Medical Service, Minneapolis VA Medical Center and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Lancet 359:2249-51. 2002
    In acute pyelonephritis, bacterial resistance to co-trimoxazole predicts treatment failure, but the clonal basis of such resistance is undefined...
  43. ncbi Is percutaneous drainage the new gold standard in the management of emphysematous pyelonephritis? Evidence from a systematic review
    Bhaskar K Somani
    University of Aberdeen, Aberdeen, Scotland, United Kingdom
    J Urol 179:1844-9. 2008
    There is no current consensus on what constitutes the ideal management of emphysematous pyelonephritis. We review the current management strategies including the role of nephron preserving percutaneous drainage in the treatment of ..
  44. pmc Transmission of an extended-spectrum-beta-lactamase-producing Escherichia coli (sequence type ST131) strain between a father and daughter resulting in septic shock and Emphysematous pyelonephritis
    Peter T Ender
    St Luke s Hospital, 801 Ostrum Street, Bethlehem, PA 18015, USA
    J Clin Microbiol 47:3780-2. 2009
    ..The father developed severe, recurrent pyelonephritis with multiple small abscesses; the daughter later developed septic shock, bacteremia, and extensive ..
  45. ncbi Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis
    L Hang
    Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden
    J Infect Dis 182:1738-48. 2000
    ..In their absence, the neutrophils are trapped, and the tissues are destroyed. This molecular deficiency may determine the progression from acute pyelonephritis to renal scarring.
  46. ncbi Diagnosis and management of acute pyelonephritis in adults
    Kalyanakrishnan Ramakrishnan
    Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am Fam Physician 71:933-42. 2005
    There are approximately 250,000 cases of acute pyelonephritis each year, resulting in more than 100,000 hospitalizations. The most common etiologic cause is infection with Escherichia coli...
  47. ncbi A trial of levofloxacin 750 mg once daily for 5 days versus ciprofloxacin 400 mg and/or 500 mg twice daily for 10 days in the treatment of acute pyelonephritis
    Howard A Klausner
    Henry Ford Hospital, Detroit, MI, USA
    Curr Med Res Opin 23:2637-45. 2007
    ..efficacy of a once-daily, 5-day course of levofloxacin 750 mg compared to a twice-daily, 10-day course of ciprofloxacin in complicated urinary tract infections (cUTI) and acute pyelonephritis (AP). This report focuses on subjects with AP.
  48. ncbi Procalcitonin: a marker of severity of acute pyelonephritis among children
    Paolo Pecile
    Department of Pediatrics, School of Medicine, University of Udine, Piazzale S M della Misericovolio Udine 33100, Italy
    Pediatrics 114:e249-54. 2004
    Febrile urinary tract infection (UTI) is a common problem among children. The diagnosis and management of acute pyelonephritis is a challenge, particularly during infancy...
  49. ncbi The osmotic stress response and virulence in pyelonephritis isolates of Escherichia coli: contributions of RpoS, ProP, ProU and other systems
    D E Culham
    Department of Microbiology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Microbiology 147:1657-70. 2001
    ..b>Pyelonephritis isolates CFT073 and HU734 were similar and diminished in osmotolerance, respectively, compared to E. coli K-12...
  50. ncbi Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis
    Lindsay E Nicolle
    Departments of Internal Medicine and Medical Microbiology, Health Sciences Centre, University of Manitoba, Winnipeg, MB, Canada
    Urol Clin North Am 35:1-12, v. 2008
    Acute uncomplicated urinary tract infection and acute pyelonephritis are very common infections affecting many women throughout their lives...
  51. ncbi Acute pyelonephritis in pregnancy
    James B Hill
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 105:18-23. 2005
    To examine the incidence of pyelonephritis and the incidence of risk factors, microbial pathogens, and obstetric complications in women with acute antepartum pyelonephritis.
  52. ncbi Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways
    Cecilia Chassin
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Unité de Formation et de Recherche de Médecine Xavier Bichat, 16 rue Henri Huchard, F 75870 Paris Cedex 18, France
    J Immunol 177:4773-84. 2006
    TLR4 plays a central role in resistance to pyelonephritis caused by uropathogenic Escherichia coli (UPEC)...
  53. pmc Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infection
    Susan R Heimer
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 72:593-7. 2004
    ..UPEC strain isolates (n = 87) and in 33% of fecal strains (n = 27), whereas pic was present in 31% of the pyelonephritis (n = 67) and 7% of the fecal strains...
  54. ncbi Usefulness of procalcitonin rapid test for the diagnosis of acute pyelonephritis in children in the emergency department
    Roya Nikfar
    Department of Pediatric Infectious Diseases, Abuzar Children s Medical Center Hospital, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Iran
    Pediatr Int 52:196-8. 2010
    ..Urinary tract infection (UTI) is a common problem in children. The aim of this study was to determine the usefulness of the procalcitonin (PCT) rapid test in the diagnosis of renal involvement in children with urinary tract infection...
  55. ncbi Risk factors for mortality in patients with emphysematous pyelonephritis: a meta-analysis
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Urol 178:880-5; quiz 1129. 2007
    Emphysematous pyelonephritis, an infection most commonly seen in cases of diabetes mellitus, is associated with considerable case fatality...
  56. ncbi Screening and treating asymptomatic bacteriuria in pregnancy
    Pisake Lumbiganon
    Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Curr Opin Obstet Gynecol 22:95-9. 2010
    Asymptomatic bacteriuria (ASB) in pregnancy, if left undiagnosed and appropriately treated can lead to acute pyelonephritis in mothers and low birth weight in infants. Urine culture is the gold standard for diagnosing ASB...
  57. pmc Bacterial characteristics in relation to clinical source of Escherichia coli isolates from women with acute cystitis or pyelonephritis and uninfected women
    James R Johnson
    Infectious Diseases 111F, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    J Clin Microbiol 43:6064-72. 2005
    Characteristics differentiating Escherichia coli strains that cause cystitis or pyelonephritis from fecal E. coli remain incompletely defined, particularly among adult women in the United States...
  58. ncbi Acute pyelonephritis in pregnancy: a retrospective study
    Paban Sharma
    Department of Obstetrics and Gynecology, Patan Hospital, Lalitpur, Nepal
    Aust N Z J Obstet Gynaecol 47:313-5. 2007
    To examine the incidence, risk factors, microbial pathogens, and pregnancy outcomes of pregnant women with acute antepartum pyelonephritis.
  59. ncbi Acute graft pyelonephritis following renal transplantation
    N S Kamath
    Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu 632004, India
    Transpl Infect Dis 8:140-7. 2006
    Urinary tract infection is the most common form of bacterial infection encountered in a renal transplant recipient. Studies explaining the long-term consequences of acute graft pyelonephritis (AGPN) are few.
  60. ncbi Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers
    R Gupta
    Department of Microbiology, Dayanand Medical College and Hospital, Tagore Nagar Civil Lines, Ludhiana, Punjab 141001, India
    Comp Immunol Microbiol Infect Dis 27:225-34. 2004
    ..radical scavengers in preventing the tissue injury using a non obstructive, ascending mouse model for chronic pyelonephritis was assessed...
  61. ncbi Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and outcomes
    Evelina Farkash
    Department of Diagnostic Radiology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Obstet Gynecol Reprod Biol 162:24-7. 2012
    To test the incidence and sonographic parameters of pyelonephritis during pregnancy, and to examine risk factors and pregnancy outcomes of women with acute antepartum pyelonephritis.
  62. ncbi Combined use of urinary alpha1-microglobulin and 99mTc DMSA scintigraphy in the diagnosis and follow-up of acute pyelonephritis and cystitis in children
    K Everaert
    Department of Urology, University Hospital of Ghent, Belgium
    Eur Urol 34:486-91. 1998
    ..of specific symptomatology in children and neurogenic bladder disease patients, the early diagnosis of acute pyelonephritis is a challenge...
  63. ncbi Is acute lobar nephronia the midpoint in the spectrum of upper urinary tract infections between acute pyelonephritis and renal abscess?
    Chi Hui Cheng
    Division of Pediatric Nephrology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Pediatr 156:82-6. 2010
    To examine acute lobar nephronia (ALN) in the spectrum of upper urinary tract infections between acute pyelonephritis (APN) and renal abscess.
  64. ncbi Risk factors of septic shock in bacteremic acute pyelonephritis patients admitted to an ER
    Jae Hoon Lee
    Department of Internal Medicine, Wonkwang University College of Medicine, 344 2, Sinyong dong, Iksan, 570 749, Republic of Korea
    J Infect Chemother 18:130-3. 2012
    Our objective was to identify factors associated with septic shock in patients with bacteremic acute pyelonephritis who were admitted to our emergency department (ER)...
  65. ncbi Efficacy of treatment with carbapenems and third-generation cephalosporins for patients with febrile complicated pyelonephritis
    Satoshi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Infect Chemother 15:390-5. 2009
    ..the clinical relevance of carbapenem and third-generation cephalosporin treatment for febrile complicated pyelonephritis, which often leads to urosepsis...
  66. pmc Intravenous doripenem at 500 milligrams versus levofloxacin at 250 milligrams, with an option to switch to oral therapy, for treatment of complicated lower urinary tract infection and pyelonephritis
    K G Naber
    Technical University of Munich, Munich, Germany
    Antimicrob Agents Chemother 53:3782-92. 2009
    ..Patients (n = 753) with complicated lower UTI or pyelonephritis were randomly assigned to receive IV doripenem at 500 mg every 8 h (q8h) or IV levofloxacin at 250 mg q24h...
  67. ncbi Diagnosis and treatment of acute pyelonephritis in women
    Richard Colgan
    Department of Family and Community Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Fam Physician 84:519-26. 2011
    Acute pyelonephritis is a common bacterial infection of the renal pelvis and kidney most often seen in young adult women. History and physical examination are the most useful tools for diagnosis...
  68. ncbi Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections
    Bryndis Ragnarsdottir
    Institute of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology MIG, Lund University, Solvegatan 23, 22362 Lund, Sweden
    Pediatr Nephrol 27:2017-29. 2012
    ..The symptoms of acute pyelonephritis are caused by the innate immune response, and inflammation in the urinary tract decreases renal tubular ..
  69. ncbi Multidrug-resistant Escherichia coli clonal groups causing community-acquired pyelonephritis
    Amee R Manges
    Division of Epidemiology, School of Public Health, University of California at Berkeley, 94720, USA
    Clin Infect Dis 38:329-34. 2004
    ..coli in a California community. This study describes the prevalence of pyelonephritis caused by CgA in the same community. E...
  70. ncbi Outcome of nephrectomy and kidney-preserving procedures for the treatment of emphysematous pyelonephritis
    Bum Soo Park
    Department of Urology, School of Medicine, Kyung Hee University, Seoul, South Korea
    Scand J Urol Nephrol 40:332-8. 2006
    Emphysematous pyelonephritis (EPN) is an acute necrotizing infection of the kidney characterized by gas formation...
  71. ncbi Severe sepsis and septic shock in pregnancy: indications for delivery and maternal and perinatal outcomes
    Candice C Snyder
    Department of Obstetrics and Gynecology, Maternal Fetal Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinanati, Ohio 45267 0526, USA
    J Matern Fetal Neonatal Med 26:503-6. 2013
    ..To report maternal and perinatal outcomes in obstetric patients with severe sepsis and septic shock...
  72. ncbi Successful treatment of ctx-m ESBL producing Escherichia coli relapsing pyelonephritis with long term pivmecillinam
    Lindsay E Nicolle
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Scand J Infect Dis 39:748-9. 2007
    Oral therapy options for pyelonephritis caused by ESBL producing E. coli are limited. We describe a woman with relapsing pyelonephritis due to a CTX-M ESBL E. coli who was cured with a prolonged course of pivmecillinam...
  73. ncbi Urinary tract infections in pregnancy
    A Ovalle
    Department of Obstetrics and Gynecology, San Borja Arriaran Clinical Hospital, Santiago, Chile
    Curr Opin Urol 11:55-9. 2001
    ..Ampicillin should not be used because of its high resistance to Escherichia coli. Pyelonephritis can cause morbidity and can be life-threatening to both mother and fetus...
  74. ncbi Comparison of extended virulence genotypes for bacteria isolated from pediatric patients with urosepsis, acute pyelonephritis, and acute lobar nephronia
    Chi Hui Cheng
    Department of Pediatrics, Division of Pediatric Nephrology, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 29:736-40. 2010
    ..This study was conducted to explore and differentiate bacterial virulence factors associated with urosepsis and 2 other severe parenchymal infections, acute pyelonephritis (APN) and acute lobar nephronia (ALN), in pediatric patients.
  75. ncbi Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis
    Mostafa Sharifian
    Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran
    Saudi J Kidney Dis Transpl 24:731-6. 2013
    ..Urinary ET-1 could be a useful marker that can be utilized in young children for diagnosis of hydronephrosis, especially obstructive cases. ..
  76. doi Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping
    A Sledzinska
    Medical University of Gdansk, Poland
    BJOG 118:266-9. 2011
  77. ncbi Clinical significance of periportal tracking as an extrarenal manifestation of acute pyelonephritis
    Robert Vollmann
    Department of Radiology, Medical University of Graz, Austria
    Abdom Imaging 36:557-60. 2011
    The purpose of this study was to evaluate whether hepatic periportal tracking (PPT) in patients with acute pyelonephritis correlates with the severity of pyelonephritis.
  78. ncbi Clofibric and ethacrynic acids prevent experimental pyelonephritis by Escherichia coli in mice
    Claudia E Balagué
    Laboratorio de Toxicologia Experimental, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
    FEMS Immunol Med Microbiol 42:313-9. 2004
    Interfering Escherichia coli attachment to the urinary tract, using P-fimbriation inhibitors, can prevent pyelonephritis. Clofibric and ethacrynic acids are organic compounds structurally related, but with different pharmacological uses...
  79. ncbi Bilateral emphysematous pyelonephritis and emphysematous cystitis with autosomal-dominant polycystic kidney disease: is conservative management justified?
    Narayanaswamy Arun
    Departments of Surgery Urology Unit and Nephrology, Al Amiri Hospital, Kuwait
    Med Princ Pract 16:155-7. 2007
    To report a case of bilateral emphysematous pyelonephritis (EPN) and emphysematous cystitis in a 64-year-old diabetic male with autosomal-dominant polycystic kidney disease (ADPKD).
  80. ncbi Effects of melatonin on suppression of renal scarring in experimental model of pyelonephritis
    Mustafa Imamoglu
    Department of Pediatric Surgery, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
    Urology 67:1315-9. 2006
    To determine the effects of melatonin combined with antibiotic administration on the suppression of renal scarring in an experimental pyelonephritis model.
  81. ncbi Extrarenal manifestations of severe acute pyelonephritis: CT findings in 21 cases
    Rivka Zissin
    Department of Diagnostic Imaging, Meir Medical Center, Kfar Saba, 44281, Israel
    Emerg Radiol 13:73-7. 2006
    The aim of this study is to report the extrarenal computerized tomography (CT) findings in patients with acute pyelonephritis (APN)...
  82. ncbi Clinical implications of healthcare-associated infection in patients with community-onset acute pyelonephritis
    Young Eun Ha
    Division of Infectious Diseases, Samsung Medical Center, Seoul, Republic of Korea
    Scand J Infect Dis 43:587-95. 2011
    Clinical and microbiological characteristics of healthcare-associated acute pyelonephritis (HCA-APN) have not been described in detail yet...
  83. ncbi Phylogenetic groups and virulence factors of Escherichia coli strains causing pyelonephritis in children with and without urinary tract abnormalities
    V Houdouin
    Laboratoire d études de génétique bactérienne dans les infections de l enfant EA3105, Universite Denis Diderot Paris 7, Paris, France
    Clin Microbiol Infect 13:740-2. 2007
    Escherichia coli isolates causing acute pyelonephritis in 93 children (25% with urinary tract abnormalities) were tested for nine virulence factors (papC, papGII, papGIII, sfa/foc, hlyC, cnf1, iucC, fyuA and iroN) and their phylogenetic ..
  84. ncbi Enterococcus hirae-related acute pyelonephritis and cholangitis with bacteremia: an unusual infection in humans
    Tze Sian Chan
    Division of Gastroenterology, Department of Internal Medicine, Taipei Medical University, Wanfang Hospital, Taipei, Taiwan
    Kaohsiung J Med Sci 28:111-4. 2012
    ..We report two patients with E hirae bacteremia caused by acute pyelonephritis and acute cholangitis. The clinical courses have been smooth on use of sensitive antibiotic therapy...
  85. ncbi Antenatal hydronephrosis and the risk of pyelonephritis hospitalization during the first year of life
    Thomas J Walsh
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    Urology 69:970-4. 2007
    To assess the risk of hospitalization for pyelonephritis within the first year of life among infants with and without antenatal hydronephrosis.
  86. ncbi Percutaneous manual aspiration embolectomy of renal vein thrombosis due to acute pyelonephritis
    Luigi Novelli
    Radiologie cardiovasculaire, HEGP, Paris, France
    Cardiovasc Intervent Radiol 30:1075-8. 2007
    ..Optimal restoration of renal vein flow was obtained by percutaneous manual aspiration embolectomy (PMAE) in this patient with contraindication to fibrinolytic therapy and surgery...
  87. ncbi [Emphysematous pyelonephritis]
    Christina Gade
    Urologisk Afdeling, Regionshospitalet Randers, DK 8900 Randers, Denmark
    Ugeskr Laeger 172:220-2. 2010
    Emphysematous pyelonephritis (EPN) is a rare, life-threatening infection of the kidney, characterized by production of gas within the renal parenchyma or perinephric tissue...
  88. pmc Increased concentration of the complement split product C5a in acute pyelonephritis during pregnancy
    Eleazar Soto
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 17:247-52. 2005
    Pregnant women with acute pyelonephritis develop acute respiratory distress syndrome (ARDS) more frequently than non-pregnant women. The reasons for this remain unknown...
  89. pmc Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and pyelonephritis d
    A Louie
    Divisions of Infectious Diseases, Albany Medical College, Albany, New York 12208, USA
    Antimicrob Agents Chemother 43:2831-40. 1999
    ..of Flu plus 5FC and Flu plus AmB in a rabbit model of Candida albicans endocarditis, endophthalmitis, and pyelonephritis. The dose of Flu used was that which resulted in an area under the concentration-time curve in rabbits ..
  90. ncbi Acute pyelonephritis: comparison of diagnosis with computed tomography and contrast-enhanced ultrasonography
    Michael Mitterberger
    Department of Urology, University of Innsbruck, Innsbruck, Austria
    BJU Int 101:341-4. 2008
    ..ultrasonography (US) with the contrast pulse-sequence (CPS) technique for detecting renal parenchymal changes in acute pyelonephritis (APN), compared with contrast-enhanced computed tomography (CT) as the reference standard.
  91. ncbi [Bilateral emphysematous pyelonephritis caused by Candida glabrata: An exceptional entity]
    Hajer Harrabi
    Service de Maladies Infectieuses, CHU Hedi Chaker, route El Ain Km 0, 5, 3029 Sfax, Tunisie
    Nephrol Ther 6:541-3. 2010
    Acute emphysematous pyelonephritis (AEP) is a severe form of urinary tract infection. It occurs usually in diabetics. The most concerned agents are the Gram-negative bacilli...
  92. ncbi Impact of discordant empirical therapy on outcome of community-acquired bacteremic acute pyelonephritis
    Seung Soon Lee
    Division of Infectious Diseases and Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang si, Korea
    J Infect 62:159-64. 2011
    ..As ciprofloxacin resistance rate of Escherichia coli causing urinary tract infections has been increasing, concern about inappropriate empirical therapy has been arisen...
  93. ncbi [Escherichia coli-induced emphysematous pyelonephritis in a diabetic patient with polycystic kidney disease]
    Vincenzo Cosentini
    U O C Nefrologia e Dialisi, Ospedale G Fracastoro di San Bonifacio, Verona, Italy
    G Ital Nefrol 28:85-8. 2011
    Emphysematous pyelonephritis is a rare, necrotizing infection of the kidney and the perirenal space resulting in the formation of gas in both structures and associated with a high mortality rate...
  94. ncbi Five patients with emphysematous pyelonephritis
    Indu Bhushan Dubey
    GTB Hospital and University College of Medical Sciences, Delhi, India
    Iran J Kidney Dis 5:204-6. 2011
    Emphysematous pyelonephritis is an acute necrotizing infection of the renal parenchyma, resulting in presence of gas within either in the collecting system or perinephric space...
  95. ncbi Emphysematous pyelonephritis
    Sarvpreet Singh Ubee
    Department of Urology, The Heart of England NHS Foundation Trust, Birmingham, UK
    BJU Int 107:1474-8. 2011
    Emphysematous pyelonephritis (EPN) is a severe necrotizing infection of the renal parenchyma. The clinical course of EPN can be severe and life-threatening if not recognized and treated promptly...
  96. ncbi Hepatic portal venous gas induced by emphysematous pyelonephritis: a rare case in hemodialytic women
    Chih Jan Chang
    Department of Emergency Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan 704, Taiwan
    Am J Emerg Med 27:1171.e1-3. 2009
    ..on abdominal computed tomography, which implied a unilateral perirenal abscess (so-called emphysematous pyelonephritis)...
  97. ncbi Contribution of quorum-sensing systems to virulence of Pseudomonas aeruginosa in an experimental pyelonephritis model
    Rahul Mittal
    Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Immunol Infect 39:302-9. 2006
    ..In the present investigation, we studied the contribution of quorum-sensing signals during the course of P. aeruginosa-induced pyelonephritis in mice.
  98. ncbi Uterine contraction frequency during treatment of pyelonephritis in pregnancy and subsequent risk of preterm birth
    Lynnae K Millar
    Kapiolani Medical Center for Women and Children, John A Burns School of Medicine, University of Hawaii at Manoa, 1319 Punahou Street, Room 540 Honolulu, Hawaii 96826
    J Perinat Med 31:41-6. 2003
    To assess ceftriaxones effect on uterine contraction frequency and determine risk factors for subsequent preterm birth in women with pyelonephritis.
  99. ncbi Maternal and perinatal outcomes in pregnancy with acute pyelonephritis
    S Pitukkijronnakorn
    Department of Obstetrics and Gynaecology, Division of Maternal and Fetal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Int J Gynaecol Obstet 89:286-7. 2005
  100. ncbi Virulence determinants, phylogenetic groups and fluoroquinolone resistance in Escherichia coli isolated from cystitis and pyelonephritis
    S Ferjani
    Laboratoire de Recherche Résistance aux Antimicrobiens, Hôpital Charles Nicolle de Tunis, Boulevard 9 avril, 1006 Tunis, Tunisia
    Pathol Biol (Paris) 60:270-4. 2012
    The aim of this study is to assess the relation between virulence genotype, phylogenetic group and susceptibility to fluoroquinolones and the urinary tract infection type including pyelonephritis and cystitis due to Escherichia coli.
  101. ncbi Evaluation of acute pyelonephritis with DMSA scans in children presenting after the age of 5 years
    Neamatollah Ataei
    Department of Pediatrics, The Children s Hospital Medical Center, Faculty of Medicine, Tehran University of Medical Sciences, Dr Gharib St Azadi Avenue, 14194 Tehran, Iran
    Pediatr Nephrol 20:1439-44. 2005
    It is generally believed that infants are more susceptible to development of renal scarring after pyelonephritis than children over 5 years old. This view has led to differences in investigations and treatment according to age...

Research Grants62

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..50% at 10 days, >90% at 28 days, 100% long term) leading to complications such as cystitis, pyelonephritis, gram-negative bacteremia, prostatitis, epididymitis, urosepsis, septicemia, orchitis, endocarditis, vertebral ..
  3. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..mixture of urine in the bladder whereas independent catheterization of ureters (split renal function) lead to pyelonephritis. In this proposal we intend to answer these questions by using a novel three-dimensional tomographer with high ..
  4. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..e., cystitis or pyelonephritis, or acute prostatitis...
  5. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..In pregnancy, GBS can cause urinary tract infections, chorioamnionitis, postpartum wound infection, pyelonephritis, sepsis, and rarely meningitis...
  6. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..The most common uropathogen, Escherichia coli, can cause acute cystitis or pyelonephritis in the uncomplicated urinary tract...
  7. Arrayed Lateral Flow Biosensor for Rapid Molecular Identification of UTI-Related
    Anjal C Sharma; Fiscal Year: 2012
    ..Up to 10% of UTIs result in serious complications such as gram-negative sepsis or chronic pyelonephritis with loss of renal function...
  8. STUDIES ON THE STRUCTURE OF BASEMENT MEMBRANES
    BILLY GERALD HUDSON; Fiscal Year: 2013
    ..binding sites for usherin, a defective protein in Usher syndrome, for bacterial Dr adhesins in chronic pyelonephritis, and for integrins...
  9. Delayed Onset of Biofilm Formation and CAUTI with Superhydrophobic Catheters
    Sanjiv Lalwani; Fiscal Year: 2011
    ..symptomatic, the resulting sequelae can range from mild (fever, urethritis and cystitis) to severe (acute pyelonephritis, renal scarring, calculu formation and bacteremia)...
  10. Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
    JAMES CARTER RICE; Fiscal Year: 2010
    ..Despite the lack of UTI symptoms, some renal transplant patients with ASB develop cystitis, pyelonephritis or acute kidney injury...
  11. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
    ..Glomerulonephritis, diabetic nephropathy, pyelonephritis, and renovascular disease together account for over 75% of patients requiring renal transplants...
  12. Biomarkers for Acute Pyelonephrititis in Children
    Nader Shaikh; Fiscal Year: 2011
    ..In others, bacteria successfully ascend from the bladder to the kidney causing acute pyelonephritis (APN). APN is one of the principal causes of acquired renal scarring in children...
  13. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..Similarly, children are afflicted with UTIs, albeit at a lower frequency but with the added risk of pyelonephritis and chronic renal dysfunction with undertreatment...
  14. IDENTIFICATION OF VUR GENES BY COMBINED LINKAGE ANALYSIS AND EXOME SEQUENCING
    RASHEED ADEBAYO GBADEGESIN; Fiscal Year: 2013
    ..PVUR is the single most important risk factor for pyelonephritis and renal parenchymal scarring in the pediatric age group...
  15. E. coli virulence gene expression during clinical UTIs in women
    Harry L Mobley; Fiscal Year: 2013
    ..UTI in humans;2) determine the iron acquisition systems required for cystitis and those required for acute pyelonephritis;and 3) Determine the toxins expressed during human UTI that predict virulence...
  16. BACTERIAL UREASE IN THE CATHETERIZED URINARY TRACT
    HARRY MOBLEY; Fiscal Year: 1990
    ..half (47%) of the gram-negative bacilli isolated produced the enzyme urease which has been implicated in pyelonephritis, hepatic coma, hyperammonemia, complement inactivation, and kidney and bladder stone formation...
  17. EMERGEncy ID Net Study
    DAVID ANDREW TALAN; Fiscal Year: 2010
    ..most recently addressing uropathogen antimicrobial resistance and outcomes among patients with acute pyelonephritis;specific host gene responses to infections;emergency physicians'(EPs) attitudes towards smallpox ..
  18. The multiple antibiotic resistance (Mar) regulon
    Stuart B Levy; Fiscal Year: 2013
    ..that MarA/SoxS/Rob enhance the ability of bacteria to persist in the murine kidney in a model of ascending pyelonephritis. Aim C will focus on the bacterial targets and pathways involved, including that of the carbon storage ..
  19. Validity of Rapid Tests to Detect Nosocomial Urinary Tract Infection in Hospital*
    THOMAS J BLODGETT; Fiscal Year: 2010
    ..has the potential to eliminate the delay in CAUTI identification and treatment in hospitalized elders, which may prevent the complications associated with high bacterial-load CAUTI, such as pyelonephritis, septic shock, and death.
  20. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott Hultgren; Fiscal Year: 2007
    ..the aggregation of human erythrocytes by bacteria expressing PapG, the bacterial adhesin associated with pyelonephritis. In addition, the flavonol extract exhibited high anti-inflammatory activity in a TPA-induced mouse ear edema ..
  21. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..coli strain isolated from a human pyelonephritis case...
  22. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    ..4) Specific Aim 4: To describe the pathogenesis of pyelonephritis during pregnancy and determine whether the infected urinary tract undergoes physiologic changes during ..
  23. PATHOGENIC MECHANISMS IN UTI
    Walter Stamm; Fiscal Year: 2007
    ..In Project 4, the association of host susceptibility to recurrent cystitis or pyelonephritis with known or novel mutations in specifically selected candidate host genes will be examined...
  24. VIRUL FACTORS OF UROPATH ESCHERICHIA COLI
    Peter Redford; Fiscal Year: 2003
    ..and the hypothesis to be tested is that they code for the factors necessary in the development of cystitis, pyelonephritis and sepsis...
  25. LIGAND RECEPTOR INTERACTIONS IN BACTERIAL ADHERENCE
    SOMAN ABRAHAM; Fiscal Year: 1993
    ..against various genera and species of Enterobacteriaceae in vitro and in vivo in a mouse model of ascending pyelonephritis. The D- mannose binding adhesin will be isolated from FimH overproducing recombinant E...
  26. E COLI PATHOGENICITY ISLANDS
    RODNEY WELCH; Fiscal Year: 1999
    ..Coli extra intestinal infections, such as pyelonephritis and sepsis are linked within PAIs...
  27. REGULATION OF E-SELECTIN DURING ACUTE INFLAMMATION
    Kevin Billups; Fiscal Year: 1999
    ..Examples of specific disorders include: pyelonephritis, cystitis, epididymitis, orchitis, and prostatitis...
  28. BACTERIAL UREASE IN UTI
    HARRY MOBLEY; Fiscal Year: 2000
    ..In addition to cystitis and acute pyelonephritis, these infections are further complicated by the production of urinary stones, a hallmark of infection with ..
  29. Immune Reconstitution in Nonhuman Primates
    Thomas Macvittie; Fiscal Year: 2005
    ..S. The most common uropathogen, Escherichia coli, can cause acute cystitis or pyelonephritis in the uncomplicated urinary tract...
  30. EFFECT OF NAVAJO INTERPRETERS ON DIABETES OUTCOMES
    Melvina McCabe; Fiscal Year: 2004
    ..non-ketotic states including coma, diabetic ketoacidosis, pneumonia, infections of the feet, skin, pyelonephritis; emergency/urgent care visits for medication refills, foot problems, hypoglycemia, urinary tract infections, ..
  31. PATHOLOGY OF EXPERIMENTAL ACUTE PYELONEPHRITIS
    TETSUO SHIMAMURA; Fiscal Year: 1980
    The role of leukocytes in renal tissue destruction which occurs in E. coli induced acute pyelonephritis has been investigated Acute pyelonephritis was produced by E. coli in the rats that were treated with cobra venom factor...
  32. CD11B/CD18 AND NEUTROPHIL EPITHELIAL INTERACTIONS
    CHARLES PARKOS; Fiscal Year: 2003
    ..ulcerative colitis, Crohn's disease), respiratory tract (bronchial pneumonia, bronchitis), and urinary tract (pyelonephritis, cystitis)...
  33. BETA-DEFENSINS IN THE FEMALE GENITAL TRACT AND KIDNEYS
    Tomas Ganz; Fiscal Year: 2000
    ..In the long term, these studies may lead to novel ways to prevent and treat several of the most common and costly human afflictions: cystitis, pyelonephritis and the major sexually transmitted diseases.
  34. Epidemiology of an uropathogenic E coli clonal group
    Lee Riley; Fiscal Year: 2003
    ..The incidence and prevalence of complications of UTI (pyelonephritis and bacteremia) caused by CgA will be determined by the analyses of E...
  35. MOLECULAR AND CELLULAR PATHOGENESES OF URINARY INFECTION
    John Warren; Fiscal Year: 2004
    ..UTI) are among the most common infections in humans which can be asymptomatic or cause cystitis, acute pyelonephritis and blood stream invasion...
  36. BACTERIAL ADHERENCE IN URINARY TRACT INFECTIONS
    DAVID UEHLING; Fiscal Year: 1980
    Bacterial invasion of the lower urinary tract commonly leads to incapacitating symptoms and ascending pyelonephritis. Despite antibiotics and corrective surgery, morbidity and mortality from urinary tract infections (UTI) are rising...
  37. ANALYSIS OF ESCHERICHIA COLI VIRULENCE DETERMINANTS
    David Low; Fiscal Year: 1992
    ..The pyelonephritis-associated pili (pap) gene cluster has been shown to encode P-adhesion activity as well as pilin monomers that ..
  38. Rim J and thermoregulation of pili transcription
    CHRISTINE WHITE ZIEGLER; Fiscal Year: 2001
    ..goal of the study proposed here is to characterize RimJ and understand how RimJ controls transcription of the pyelonephritis-associated pili (pap) operon in response to changes in temperature...
  39. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2006
    ..The oxyR strain also appears to be markedly attenuated for virulence in a mouse model of ascending pyelonephritis. This proposal seeks to characterize oxyR effects more fully, and to explore the effects of selected other ..
  40. VASCULAR ENDOTHELIAL CADHERIN FUNCTION IN INFLAMMATION
    SUNIL SHAW; Fiscal Year: 2003
    ..ulceration, celiac sprue, Crohn disease and ulcerative colitis, glomerulonephritis, interstitial nephritis and pyelonephritis are all characterized by the activation of inflammatory cells leading to tissue injury...
  41. ANTI-REFLUX SURGERY FOR LONG-TERM URINARY DIVERSION
    Jerome Richie; Fiscal Year: 1980
    ..of anti-refluxing colonic conduits compared to freely refluxing ileal conduits in the prevention of pyelonephritis. This study is designed to evaluate the possible long-term detrimental effects of reflux in urinary conduit ..
  42. IMMUNIZATION AGAINST URINARY TRACT INFECTION
    DAVID UEHLING; Fiscal Year: 2001
    ..Even in patients without demonstrable vesico-ureteral reflux or obstruction, an lower tract UTI may proceed to pyelonephritis. The overall goal of this research continues to be establishment of a safe and effective vaccine treatment ..
  43. NCRR Shared Instrumentation/1H (13C/15N) 5mm Cold Probe
    Frederick Dahlquist; Fiscal Year: 2005
    ..of the proteins involved in the epigenetic control of the expression of genes that encode proteins present in pyelonephritis-associated pili; the structure an assembly of tau protein; structural elucidation of marine siderophores; ..
  44. Control of bladder infections by NF-kappaB
    Matthew Mulvey; Fiscal Year: 2005
    Urinary tract infections, including cystitis and pyelonephritis, are among the most common of infectious diseases acquired by humans. These infections are responsible for substantial morbidity, mortality and high medical costs worldwide...
  45. Anti-Adhesion Mechanisms of Cranberry Constituents on E. coli
    Terri Camesano; Fiscal Year: 2009
    ..In particular, we are focusing on P-fimbriated E. coli, which cause the most serious type of UTI, acute pyelonephritis (kidney infection). These infections often develop when P-fimbriated E. coli ascend from the bladder...
  46. ROLE OF BACTERIAL LECTINS IN KIDNEY DISEASES
    Bogdan Nowicki; Fiscal Year: 2000
    ..Dr-tissue-ligand interaction resulted in the development of an experimental model of ascending chronic pyelonephritis (ChP) that fulfills histological requirements for human ChP...
  47. DNA METHYLATION-BASED BIOMARKERS OF UTI OUTCOME
    JEFFREY JEDDELOH; Fiscal Year: 2005
    ..Ideally, our biomarkers will not only be capable of discriminating cystits inducing strains from pyelonephritis inducing strains, but also providing a measure of relative virulence through the analysis of the methylation ..
  48. INTERNATIONAL WORKSHOP ON REFLUX AND PYELONEPHRITIS
    James Roberts; Fiscal Year: 1991
    The specific aim of this workshop on reflux and pyelonephritis is to determine the relation of the two disorders, reflux and bacterial infection to renal damage...
  49. Feedback regulation of innate immune signaling at mucosal surfaces
    Derek Abbott; Fiscal Year: 2009
    ..is an initiating event in a variety of inflammatory disorders including Inflammatory Bowel Disease, Asthma, Pyelonephritis and a number of primary immunodeficiencies...
  50. Purchase of an 800 MHz NMR spectrometer
    Frederick Dahlquist; Fiscal Year: 2006
    ..of the proteins involved in the epigenetic control of the expression of genes that encode proteins present in pyelonephritis-associated pili; the structure and assembly of tau protein; and the structures of complexes of proteins and ..
  51. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  52. Prediciting Severe Neonatal Hyperbilirubinemia
    Ron Keren; Fiscal Year: 2007
    ....
  53. INTERLEUKIN-12 REGULATION BY DR-FIMBRIATED E. COLI
    Pawel Goluszko; Fiscal Year: 2002
    ..The investigators propose to evaluate in three Specific Aims the general hypothesis that cross-linking of DAF on human monocytes/macrophages by E. coli bearing Dr fimbriae inhibits IL-2 production. ..
  54. Ectopic Pregnancy: Assessing Long-Term Trends in Rates and Risk Factors
    Delia Scholes; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  55. Oral Contraceptive Use and Bone Density in Young Women
    Delia Scholes; Fiscal Year: 2008
    ..abstract_text> ..