glomerulonephritis

Summary

Summary: Glomerular disease characterized by an inflammatory reaction, with leukocyte infiltration and cellular proliferation of the glomeruli, or that appears to be the result of immune glomerular injury.

Top Publications

  1. ncbi The classification of glomerulonephritis in systemic lupus erythematosus revisited
    Jan J Weening
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 15:241-50. 2004
  2. pmc P2X7 deficiency attenuates renal injury in experimental glomerulonephritis
    Simon R J Taylor
    MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
    J Am Soc Nephrol 20:1275-81. 2009
  3. ncbi Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
    Thilo Kruger
    Department of Nephrology and Clinical Immunology, University Clinic of Aachen, Aachen, Germany
    J Am Soc Nephrol 15:613-21. 2004
  4. ncbi Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis
    Uta Kunter
    Division of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 17:2202-12. 2006
  5. pmc A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis
    K Makibayashi
    Division of Artificial Kidneys and the Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
    Am J Pathol 158:1733-41. 2001
  6. ncbi Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in experimental glomerulonephritis
    Hideki Uchimura
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 16:997-1004. 2005
  7. pmc Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis
    Guillaume Bollée
    Unité Mixte de Recherche UMR 970, Paris Cardiovascular Research Centre, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Nat Med 17:1242-50. 2011
  8. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011
  9. ncbi Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis
    Hidetoshi Tsuda
    Dept of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Renal Physiol 299:F1004-13. 2010
  10. ncbi Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis
    Cosimo Stambe
    Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 14:338-51. 2003

Research Grants

Detail Information

Publications328 found, 100 shown here

  1. ncbi The classification of glomerulonephritis in systemic lupus erythematosus revisited
    Jan J Weening
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 15:241-50. 2004
    ..hypercellularity; II, mesangial immune deposits with mesangial hypercellularity); class III for focal glomerulonephritis (involving <50% of total number of glomeruli) with subdivisions for active and sclerotic lesions; class ..
  2. pmc P2X7 deficiency attenuates renal injury in experimental glomerulonephritis
    Simon R J Taylor
    MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
    J Am Soc Nephrol 20:1275-81. 2009
    ..protein in mesangial cells and macrophages infiltrating the glomeruli in animal models of antibody-mediated glomerulonephritis. In this study, we used P2X7-knockout mice in the same experimental model of glomerulonephritis and found ..
  3. ncbi Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
    Thilo Kruger
    Department of Nephrology and Clinical Immunology, University Clinic of Aachen, Aachen, Germany
    J Am Soc Nephrol 15:613-21. 2004
    ..In nephrotoxic glomerulonephritis, increased numbers of CD11c(+) cells showing DC functionality were found in the tubulointerstitium...
  4. ncbi Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis
    Uta Kunter
    Division of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 17:2202-12. 2006
    ..1 glomerulonephritis was studied...
  5. pmc A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis
    K Makibayashi
    Division of Artificial Kidneys and the Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
    Am J Pathol 158:1733-41. 2001
    ..In the present study, we report a study of the effect of OCT on anti-thy-1 glomerulonephritis. Both OCT and 1,25(OH)(2)D(3) significantly inhibited mesangial cell proliferation, the degree of ..
  6. ncbi Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in experimental glomerulonephritis
    Hideki Uchimura
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 16:997-1004. 2005
    ..1 glomerulonephritis. The decrease in glomerular endothelial cells was significantly attenuated in the left kidney, as compared ..
  7. pmc Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis
    Guillaume Bollée
    Unité Mixte de Recherche UMR 970, Paris Cardiovascular Research Centre, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Nat Med 17:1242-50. 2011
    Rapidly progressive glomerulonephritis (RPGN) is a life-threatening clinical syndrome and a morphological manifestation of severe glomerular injury that is marked by a proliferative histological pattern ('crescents') with accumulation of ..
  8. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011
    ..Together, the NLRP3-ASC-caspase-1 axis does not contribute to intrinsic glomerular inflammation via glomerular parenchymal cells as these cannot produce IL-1β during sterile inflammation...
  9. ncbi Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis
    Hidetoshi Tsuda
    Dept of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Renal Physiol 299:F1004-13. 2010
    ..Here, we investigated whether allogenic FM-MSC administration could ameliorate renal injury in experimental glomerulonephritis. Lewis rats with anti-Thy1 nephritis intravenously received FM-MSC obtained from major histocompatibility ..
  10. ncbi Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis
    Cosimo Stambe
    Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 14:338-51. 2003
    ..MAPK (phosphorylated p38, p-p38) within 3 h of the induction of rat anti-glomerular basement membrane (GBM) glomerulonephritis and localized p-p38 and p-ATF-2 to infiltrating neutrophils, with increased staining of podocytes and ..
  11. pmc A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice
    Lin Leng
    Department of Medicine, Yale University, New Haven, CT 06520, USA
    J Immunol 186:527-38. 2011
    ..MIF and its receptor, CD74, and in each model of disease, it reduced functional and histological indices of glomerulonephritis, CD74(+) and CXCR4(+) leukocyte recruitment, and proinflammatory cytokine and chemokine expression...
  12. ncbi Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion
    Sanjeev Sethi
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 81:434-41. 2012
    Membranoproliferative glomerulonephritis (MPGN) denotes a general pattern of glomerular injury that is easily recognized by light microscopy. With additional studies, MPGN subgrouping is possible...
  13. ncbi Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats
    Jian Guo Wu
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    Phytomedicine 16:1033-41. 2009
    Membranous glomerulonephritis (MGN) remains the most common cause of adult-onset nephrotic syndrome in the world and up to 40% of untreated patients will progress to end-stage renal disease...
  14. ncbi T cell cross-talk with kidney dendritic cells in glomerulonephritis
    Ulf Panzer
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Mol Med (Berl) 88:19-26. 2010
    T cells have long been suspected to contribute to glomerulonephritis not only as helpers for antibody-producing B cells, but also as immune effector cells...
  15. ncbi Cryoprecipitate of patients with cryoglobulinemic glomerulonephritis contains molecules of the lectin complement pathway
    I Ohsawa
    Internal Medicine II, Nihon University School of Medicine, Tokyo, Japan
    Clin Immunol 101:59-66. 2001
    ..carried out to explore the role of the lectin complement pathway in the pathogenesis of cryoglobulinemic glomerulonephritis. Sixteen patients with mixed cryoglobulinemia type II with glomerulonephritis (GN) were enrolled...
  16. pmc Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
    Jacques Behmoaras
    Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Genet 40:553-9. 2008
    Crescentic glomerulonephritis is an important cause of human kidney failure for which the underlying molecular basis is largely unknown...
  17. pmc Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis
    Daniel P Gale
    Division of Medicine, University College, London, UK
    Lancet 376:794-801. 2010
    ..We aimed to establish the genetic basis for a familial disorder of complement regulation associated with persistent microscopic haematuria, recurrent macroscopic haematuria, glomerulonephritis, and progressive renal failure.
  18. ncbi Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2
    Heather J Brown
    Department of Nephrology and Transplantation, 5th Floor Thomas Guy House, Guy s Hospital, St Thomas Street, London, UK
    J Am Soc Nephrol 18:1732-9. 2007
    Autoimmune diseases such as glomerulonephritis are exacerbated by infection. This study examined the effect of the Toll-like receptor 4 (TLR4) ligand lipid A on the development of heterologous nephrotoxic nephritis...
  19. ncbi C3 glomerulopathy: a new classification
    Fadi Fakhouri
    Departement de Nephrologie, INSERM UMR643, CHU de Nantes, 1 Place Alexis Ricordeau, 44000 Nantes, France
    Nat Rev Nephrol 6:494-9. 2010
    ..In the future, it could help to identify individuals who might benefit from therapeutic inhibition of the complement system...
  20. ncbi Pathways to nephron loss starting from glomerular diseases-insights from animal models
    Wilhelm Kriz
    Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 67:404-19. 2005
    ..The only option for extracapillary injuries with tuft adhesion is repair by formation of a segmental adherent scar (i.e., segmental glomerulosclerosis)...
  21. ncbi Fractional excretions of albumin and IgG are the best predictors of progression in primary glomerulonephritis
    Emily P McQuarrie
    Renal Research Group, British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Nephrol Dial Transplant 26:1563-9. 2011
    ..We aimed to assess the utility of available indices of IgG, total proteinuria and albumin excretions as predictors of chronic kidney disease (CKD) progression in patients with primary glomerulonephritis.
  22. pmc Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells
    Bart Smeets
    Department of Nephrology and Immunology, University Hospital of the Aachen University of Technology, Pauwelsstrasse 30, Aachen, Germany
    J Am Soc Nephrol 20:2604-15. 2009
    Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown...
  23. pmc Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis
    Markus Wornle
    Medical Policlinic, Ludwig Maximilians University, Munchen, Germany
    Am J Pathol 168:370-85. 2006
    Hepatitis C virus (HCV) infection is frequently complicated by glomerulonephritis with immune complexes containing viral RNA...
  24. ncbi Increased expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human glomerulonephritis
    Clare M Turner
    Epithelial Transport and Cell Biology Group, Department of Physiology, University College London Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    Nephrol Dial Transplant 22:386-95. 2007
    The involvement of IL-1beta and other pro-inflammatory cytokines in most forms of glomerulonephritis is now well established...
  25. ncbi Risk of renal allograft loss from recurrent glomerulonephritis
    Esther M Briganti
    Department of Epidemiology and Preventive Medicine, Monash University, Clayton, Victoria, Australia
    N Engl J Med 347:103-9. 2002
    Recurrent glomerulonephritis is a known cause of renal allograft loss; however, the incidence of this complication is poorly defined...
  26. pmc Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains
    K Maratou
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Genes Immun 12:78-89. 2011
    Crescentic glomerulonephritis (CRGN) is a major cause of rapidly progressive renal failure for which the underlying genetic basis is unknown. Wistar-Kyoto (WKY) rats show marked susceptibility to CRGN, whereas Lewis rats are resistant...
  27. ncbi Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life
    Wendy E Hoy
    Centre for Chronic Disease, University of Queensland, Herston, Queensland, Australia
    Kidney Int 81:1026-32. 2012
    Although unusual in western countries and in Australia in general, post-streptococcal glomerulonephritis (PSGN) is still common in Australian Aboriginal children living in remote communities...
  28. pmc Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis
    Melanie S Joy
    Division of Nephrology and Hypertension, UNC Kidney Center, University of North Carolina School of Medicine, Chapel Hill, USA
    Br J Clin Pharmacol 74:445-55. 2012
    Cyclophosphamide, the precursor to the active 4-hydroxycyclophosphamide, is used in active glomerulonephritis despite limited pharmacokinetics data. The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide were evaluated...
  29. ncbi P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis
    Simona Deplano
    Hammersmith Hospital, Du Cane Rd, London, UK
    J Leukoc Biol 93:127-34. 2013
    ..In conclusion, we propose a novel mechanism, whereby genetically determined P2RX7 levels in macrophages regulate Nlrp3-inflammasome activation and susceptibility to Crgn...
  30. pmc Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis
    Akira Mima
    Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    PLoS ONE 6:e17929. 2011
    ..growth factor (PDGF) plays critical roles in mesangial cell (MC) proliferation in mesangial proliferative glomerulonephritis. We showed previously that Smad1 contributes to PDGF-dependent proliferation of MCs, but the mechanism by ..
  31. ncbi Overview: end-stage renal disease in the developing world
    Rashad S Barsoum
    Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Artif Organs 26:737-46. 2002
    ..b>Glomerulonephritis, rather than diabetes, remains as the main cause of ESRD with significant geographical variations in the ..
  32. pmc Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement
    Sanjeev Sethi
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 83:293-9. 2013
    Postinfectious glomerulonephritis is a common disorder that develops following an infection. In the majority of cases, there is complete recovery of renal function within a few days to weeks following resolution of the infection...
  33. ncbi HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 67:1381-90. 2005
    ..segmental glomerulosclerosis (FSGS) [HIV-associated nephropathy (HIVAN)], immune complex-mediated forms of glomerulonephritis have been increasingly reported...
  34. pmc Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice
    Alexander Jacob
    Department of Medicine, The University of Chicago, Chicago, IL, USA
    Immunology 139:328-37. 2013
    ..of the complement cascade and protects C57BL/6 mice from immune complex-mediated complement-dependent glomerulonephritis. In chronic serum sickness (CSS) there are increased deposits of immune complexes in the glomeruli with ..
  35. pmc Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis
    Bart Smeets
    Department of Pathology, Radboud University Nijmegen Medical Center, Geert Grooteplein 24, Nijmegen, Netherlands
    J Am Soc Nephrol 20:2593-603. 2009
    ..transcriptase-PCR to demonstrate that hypercellular lesions of different podocytopathies and crescentic glomerulonephritis consist of three distinct populations: CD133(+)CD24(+)podocalyxin (PDX)(-)nestin(-) renal progenitors, CD133(..
  36. pmc Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci
    M L Watson
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    J Exp Med 176:1645-56. 1992
    ..T cells in lymphoid tissue and many features of generalized autoimmune disease, including immune complex glomerulonephritis. To positionally clone the lpr mutation and analyze the effects of background genes, backcross offspring ..
  37. ncbi Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium
    Sigridur A Asgeirsdottir
    Medical Biology Section, Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Mol Pharmacol 72:121-31. 2007
    b>Glomerulonephritis represents a group of renal diseases with glomerular inflammation as a common pathologic finding...
  38. pmc Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies
    C Mohan
    Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
    J Clin Invest 103:1685-95. 1999
    ..Sle3, exhibit low-grade polyclonal B- and T-cell activation, elevated CD4/CD8 ratios, and mildly penetrant glomerulonephritis. In contrast to these monocongenics, the present study reveals that B6...
  39. ncbi Recurrent dense deposit disease after renal transplantation: an emerging role for complementary therapies
    J A McCaughan
    Regional Nephrology Unit, Belfast City Hospital, Belfast, Northern Ireland
    Am J Transplant 12:1046-51. 2012
    Dense deposit disease is a rare glomerulonephritis caused by uncontrolled stimulation of the alternative complement pathway. Allograft survival after kidney transplantation is significantly reduced by the high rate of disease recurrence...
  40. ncbi Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Kidney Dis 42:575-81. 2003
    ..We present the hypothesis that this imbalance may help explain the predilection for membranoproliferative glomerulonephritis (GN) and mesangial proliferative GN to be associated with developing and/or poor nations, whereas ..
  41. ncbi CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis
    Ming Li
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Clayton, Victoria, Australia
    J Immunol 177:3406-12. 2006
    ..We tested the hypothesis that CD100 plays a pathogenetic role in experimental immune complex glomerulonephritis. Daily injection of horse apoferritin for 14 days induced immune complex formation, mesangial proliferative ..
  42. pmc Quantitative and qualitative urinary cellular patterns correlate with progression of murine glomerulonephritis
    Junpei Kimura
    Laboratory of Anatomy, Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS ONE 6:e16472. 2011
    ..We investigated the quantitative and qualitative urinary cellular patterns in a murine glomerulonephritis model and elucidated the correlation between cellular patterns and renal pathology...
  43. ncbi Glomerulonephritis
    W G Couser
    University of Washington, Department of Medicine, UWMC, Seattle 98195, USA
    Lancet 353:1509-15. 1999
    The differential diagnosis of glomerulonephritis without systemic disease includes poststreptococcal glomerulonephritis, IgA nephropathy, rapidly progressive glomerulonephritis (RPGN), and membranoproliferative glomerulonephritis (MPGN)...
  44. ncbi Monocytes and peritubular capillary C4d deposition in acute renal allograft rejection
    Alex B Magil
    Department of Pathology, St Paul s Hospital and the Unversity of British Columbia, Vancouver, BC, Canada
    Kidney Int 63:1888-93. 2003
    ..Monocyte/macrophage (MO) infiltration of renal allografts has been shown to adversely affect graft survival. The purpose of this study was to assess whether the two phenomena are related...
  45. ncbi Antibody blockade of TNF-alpha reduces inflammation and scarring in experimental crescentic glomerulonephritis
    Sarah B Khan
    Renal Section and Department of Histopathology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Kidney Int 67:1812-20. 2005
    ..We hypothesised that blocking TNF-alpha with a monoclonal antibody would prevent inflammation and renal fibrosis in crescentic glomerulonephritis.
  46. ncbi D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease
    Frank Bienaime
    Department of Nephrology and Dialysis, Tenon Hospital, APHP, Paris, France
    Am J Kidney Dis 50:821-5. 2007
    ..The presentation and rapidly progressive and potentially severe outcome of this complication dramatically contrast with those of membranous and minimal change glomerulopathy, also induced by the sulfhydryl compound...
  47. ncbi Hepatitis B virus-associated nephropathy
    Rajendra Bhimma
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Am J Nephrol 24:198-211. 2004
    ..The most effective tool in reducing the incidence of the disease is the use of HBV vaccines...
  48. ncbi Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 14:317-26. 2003
    Immune complex glomerulonephritis (GN) often deteriorates during infection with viruses and bacteria that, in contrast to mammals, have DNA that contains many unmethylated CpG motifs...
  49. pmc Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis
    Katharina Flür
    Medical Policlinic, University of Munich, Germany
    Am J Pathol 175:2014-22. 2009
    ..Thus, TLR-independent recognition of viral RNA is a potent inducer of type I interferon in mesangial cells, which can be an important mediator of virally induced glomerulonephritis.
  50. ncbi The spectrum of podocytopathies: a unifying view of glomerular diseases
    R C Wiggins
    Nephrology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0676, USA
    Kidney Int 71:1205-14. 2007
    ....
  51. ncbi Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis
    H J Anders
    Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University Munich, Munich, Germany
    J Am Soc Nephrol 12:919-31. 2001
    ..participate in leukocyte infiltration, which plays a major role in glomerular injury during immune complex glomerulonephritis (IC-GN)...
  52. ncbi Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis
    Claudio Bazzi
    Division of Nephrology and Dialysis and Biochemical Laboratory, San Carlo Borromeo Hospital, Milan, Italy
    Nephrol Dial Transplant 17:1890-6. 2002
    ..The second aim was to assess whether NAG excretion has a predictive value on functional outcome and response to therapy...
  53. ncbi Acute postinfectious glomerulonephritis in the modern era: experience with 86 adults and review of the literature
    Samih H Nasr
    Department of Pathology, Division of Nephrology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Medicine (Baltimore) 87:21-32. 2008
    Acute postinfectious glomerulonephritis (APIGN) is uncommon in adults, and its incidence is progressively declining in developed countries. To our knowledge there are no modern North American series addressing epidemiology and outcome...
  54. pmc Fibrillary glomerulonephritis: a report of 66 cases from a single institution
    Samih H Nasr
    Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20, 200 First Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 6:775-84. 2011
    Fibrillary glomerulonephritis (FGN) is a rare primary glomerular disease. Most previously reported cases were idiopathic...
  55. ncbi Reversible posterior leucoencephalopathy syndrome in post streptococcal glomerulonephritis
    Shalu Gupta
    Division of Pediatric Intensive Care Unit, Department of Pediatrics, Chacha Nehru Bal Chikitsalya affiliated to Maulana Azad Medical College, Geeta Colony, Delhi, India
    Indian Pediatr 47:274-6. 2010
    ..We report a case of post streptococcal glomerulonephritis presenting as reversible leukoencephalopathy syndrome...
  56. ncbi Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 12:2300-9. 2001
    ..Retinoids have previously been shown to significantly limit glomerular damage in rat experimental glomerulonephritis. Therefore, the effects of all-trans retinoic acid and isotretinoin on the components of the TGF-beta system ..
  57. pmc Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus
    Olivier C Meyer
    Rheumatology Unit, Bichat Hospital, APHP, 75018 Paris, France
    Arthritis Res Ther 11:R87. 2009
    ..Autoantibodies against C1q correlate with lupus nephritis. We compared titers of anti-C1q and anti-dsDNA in 70 systemic lupus erythematosus patients with (n = 15) or without (n = 55) subsequent biopsy-proven lupus nephritis...
  58. ncbi Transplant glomerulopathy
    F G Cosio
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Transplant 8:492-6. 2008
    ..However, it is also likely that an improved understanding of TG pathogenesis will result in the development of effective therapies for this form of progressive kidney allograft damage...
  59. pmc Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury
    Felix Heymann
    Institutes for Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, Bonn, Germany
    J Clin Invest 119:1286-97. 2009
    ..and inflammation of parietal epithelial cells, similar to lesions frequently observed in human chronic glomerulonephritis. Repetitive T cell injections aggravated infiltration and caused progression to structural and functional ..
  60. ncbi Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis
    Marcus J Moeller
    Division of Nephrology, Department of Internal Medicine, University of Michigan, and Department of Veterans Affairs, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 15:61-7. 2004
    Cellular crescents are a defining histologic finding in many forms of inflammatory glomerulonephritis. Despite numerous studies, the origin of glomerular crescents remains unresolved...
  61. pmc Membranous glomerulonephritis with ANCA-associated necrotizing and crescentic glomerulonephritis
    Samih H Nasr
    Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC14 224, New York, NY 10032, USA
    Clin J Am Soc Nephrol 4:299-308. 2009
    Only rare cases of concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been reported.
  62. pmc Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Immunol 183:6831-8. 2009
    ..Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ...
  63. ncbi Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice
    Mei Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nat Med 12:1081-7. 2006
    Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by loss of renal function within days to weeks and by glomerular crescents on biopsy...
  64. ncbi Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure
    G Einecke
    Alberta Transplant Applied Genomics Centre, Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2520-31. 2009
    ..b>Glomerulonephritis accounted for 6/27 late losses, whereas T-cell-mediated rejection, drug toxicity and unexplained scarring ..
  65. ncbi Podocyte biology and the emerging understanding of podocyte diseases
    Laura Barisoni
    Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA
    Am J Nephrol 23:353-60. 2003
    ..The major podocytopathies can also be organized into four categories, including those with a normal glomerular histology, diffuse mesangial sclerosis, focal segmental glomerulosclerosis, and collapsing glomerulopathy...
  66. pmc C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis
    Adrian Schreiber
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Berlin, Germany
    J Am Soc Nephrol 20:289-98. 2009
    Anti-neutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis (NCGN) requires complement participation in its pathogenesis...
  67. ncbi Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury
    Masanori Hara
    Department of Pediatrics, Yoshida Hospital, Yoshida machi, Nishikanbara gun, 959 0242 Niigata, Japan
    J Am Soc Nephrol 16:408-16. 2005
    ..In conclusion, podocyte apical cell membranes are shed into the urine from injured podocytes, indicating a previously unrecognized manifestation of podocyte injury...
  68. pmc Membranoproliferative glomerulonephritis
    Bassam Alchi
    Renal Unit, Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
    Pediatr Nephrol 25:1409-18. 2010
    Membranoproliferative glomerulonephritis is an uncommon kidney disorder characterized by mesangial cell proliferation and structural changes in glomerular capillary walls...
  69. pmc Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
    Renate Kain
    Department of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Nat Med 14:1088-96. 2008
    Pauci-immune focal necrotizing glomerulonephritis (FNGN) is a severe inflammatory disease associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA)...
  70. pmc Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Am J Pathol 164:1967-77. 2004
    The involvement of proinflammatory cytokines interleukin (IL)-1 and tumor necrosis factor (TNF) in crescentic glomerulonephritis (GN) is well established...
  71. ncbi Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Science 304:1147-50. 2004
    ..MFG-E8-/- mice developed splenomegaly, with the formation of numerous germinal centers, and suffered from glomerulonephritis as a result of autoantibody production...
  72. pmc Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees
    Yiannis Athanasiou
    Department of Nephrology, Nicosia General Hospital, Nicosia, Cyprus
    Clin J Am Soc Nephrol 6:1436-46. 2011
    ..A subgroup of patients, particularly men, develop additional proteinuria, hypertension, and chronic renal disease or ESRD...
  73. pmc The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis
    Hans Joachim Paust
    Universitatsklinikum Hamburg Eppendorf, III Medizinische Klinik, Martinistrasse 52, 20246 Hamburg, Germany
    J Am Soc Nephrol 20:969-79. 2009
    T cells infiltrate the kidney in both human and experimental glomerulonephritis, and several lines of evidence indicate that T cell-mediated tissue damage plays an important role in the immunopathogenesis of renal inflammatory diseases...
  74. pmc Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis
    M Yanagita
    Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara cho, Sho goin, Sakyo ku, Kyoto 606 8507, Japan
    Am J Pathol 158:1423-32. 2001
    ..therefore, we examined in vivo roles of Gas6 and Axl in an experimental model of mesangial proliferative glomerulonephritis induced by the injection of anti-Thy1.1 antibody (Thy1 GN)...
  75. ncbi Histopathologic classification of ANCA-associated glomerulonephritis
    Annelies E Berden
    Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
    J Am Soc Nephrol 21:1628-36. 2010
    ..cytoplasmic antibody (ANCA)-associated vasculitis is the most common cause of rapidly progressive glomerulonephritis worldwide, and the renal biopsy is the gold standard for establishing the diagnosis...
  76. pmc Viral RNA and DNA trigger common antiviral responses in mesangial cells
    Ramanjaneyulu Allam
    Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 20:1986-96. 2009
    Extrarenal viral infections commonly trigger glomerulonephritis, usually in association with immune complex disease...
  77. ncbi WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    Jian Kan Guo
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hum Mol Genet 11:651-9. 2002
    ..transgenic mouse models, we demonstrate that reduced expression levels of WT1 result in either crescentic glomerulonephritis or mesangial sclerosis depending on the gene dosage...
  78. ncbi Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis
    Satoshi Hisano
    Department of Pathology, Faculty of Medicine, Fukuoka University, Nanakuma, Fukuoka, Japan
    Pathol Int 57:351-7. 2007
    ..the correlation between complement pathways and clinicopathological findings in post-streptococcal acute glomerulonephritis (PSAGN)...
  79. ncbi Crescentic glomerulonephritis: new aspects of pathogenesis
    Ruth M Tarzi
    Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Semin Nephrol 31:361-8. 2011
    This review provides a summary of recent advances in the understanding of crescentic glomerulonephritis, focusing on antineutrophil cytoplasm antibody (ANCA)-associated vasculitis and anti-glomerular basement membrane (anti-GBM) antibody ..
  80. ncbi Clinicopathologic predictors of death and ESRD in patients with pauci-immune necrotizing glomerulonephritis
    Penelope P Kapitsinou
    Department of Pathophysiology, Medical School, University of Athens, Athens, Greece
    Am J Kidney Dis 41:29-37. 2003
    Pauci-immune necrotizing glomerulonephritis (PING) occurs in various settings and has a very variable prognosis. We investigated whether clinicopathologic findings at the time of renal biopsy may predict major disease outcomes.
  81. pmc Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages
    Richard P Hull
    MRC Clinical Sciences Centre, Imperial College London, HammersmithHospital, Du Cane Road W12 0NN, London, UK
    BMC Genomics 14:92. 2013
    ..The WKY rat strain is uniquely susceptible to experimentally induced macrophage-dependent crescentic glomerulonephritis (Crgn)...
  82. ncbi C3 glomerulopathy masquerading as acute postinfectious glomerulonephritis
    Gagangeet Sandhu
    Division of Nephrology, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Kidney Dis 60:1039-43. 2012
    ..Kidney biopsy showed diffuse proliferative and exudative glomerulonephritis with C3-dominant staining by immunofluorescence...
  83. ncbi Predicting kidney function from renal biopsy. Semiquantitative versus quantitative approach
    Krzysztof Okon
    Chair and Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 58:65-71. 2007
    The term glomerulonephritis encompass a heterogeneous group of diseases; these are a important cause of end stage renal disease...
  84. ncbi Systematic Review: Estimation of global burden of non-suppurative sequelae of upper respiratory tract infection: rheumatic fever and post-streptococcal glomerulonephritis
    Stewart J Jackson
    Centre for Population Sciences, University of Edinburgh, Edinburgh, UK
    Trop Med Int Health 16:2-11. 2011
    To establish the incidence of post-streptococcal glomerulonephritis (PSGN) and acute rheumatic fever, the prevalence of rheumatic heart disease (RHD), and to estimate morbidity and mortality caused by these diseases globally.
  85. ncbi Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    M Botto
    Rheumatology Section, Hammersmith Campus, Imperial College School of Medicine, London, UK
    Nat Genet 19:56-9. 1998
    ..Of the C1qa-/- mice, 25% had glomerulonephritis with immune deposits and multiple apoptotic cell bodies...
  86. ncbi Role of rituximab therapy in glomerulonephritis
    David Jayne
    Renal Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Am Soc Nephrol 21:14-7. 2010
    ..rituximab is attracting increasing attention in systemic lupus erythematosus, vasculitis, and primary glomerulonephritis. Existing, uncontrolled data report high response rates in patients with refractory disease...
  87. pmc Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers
    J Floege
    Division of Nephrology, Medizinische Hochschule, Hannover, Germany
    Am J Pathol 154:169-79. 1999
    ..In vivo effects of the aptamer were evaluated in a rat mesangioproliferative glomerulonephritis model. Twice-daily intravenous (i.v.) injections from days 3 to 8 after disease induction of 2...
  88. pmc Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice
    N S Sheerin
    Department of Nephrology and Transplantation, Guy s Hospital, UMDS, London, UK
    Clin Exp Immunol 110:403-9. 1997
    ..These studies support a critical role for complement in the development of anti-GBM disease. However, the protective effect of complement deficiency can be broken if the dose of nephritogenic antibody is increased...
  89. pmc Clinical outcomes and predictors for ESRD and mortality in primary GN
    Yu Hsiang Chou
    Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Yun Lin branch, Yunlin County, Taiwan
    Clin J Am Soc Nephrol 7:1401-8. 2012
    Relatively little is known about the long-term outcomes of different histologic types of primary glomerulonephritis in Asian populations.
  90. ncbi Improved outcome in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a 30-year follow-up study
    Marc Hilhorst
    Department of Internal Medicine Division of Clinical and Experimental Immunology, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Nephrol Dial Transplant 28:373-9. 2013
    Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has a poor prognosis. In the current study, we assessed whether prognosis in these patients improved over the last three decades.
  91. ncbi Mortality and renal outcome of primary glomerulonephritis in Korea: observation in 1,943 biopsied cases
    Hajeong Lee
    Department of Internal Medicine, Seoul National University Hospital, Seongnam, Republic of Korea
    Am J Nephrol 37:74-83. 2013
    Previous epidemiological studies have focused on the prevalence of primary glomerulonephritis (GN), but few have explored long-term patient outcomes...
  92. ncbi Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies
    Takao Masaki
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 15:1835-43. 2004
    ..ERK activation may promote renal repair through tubular proliferation while promoting renal fibrosis via proliferation of glomerular and interstitial myofibroblasts...
  93. ncbi Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
    Elisabeth Dittrich
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, 1090 Vienna, Austria
    Transpl Int 17:215-20. 2004
    ..We report, however, on four kidney-transplant recipients who developed post-transplantation glomerulonephritis after conversion from a calcineurin-inhibitor-based immunosuppression to rapamycin...
  94. ncbi The spectrum of antibody-mediated renal allograft injury: implications for treatment
    J Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Transplant 8:1367-73. 2008
    ..Although effective therapy is available for acute AMR, allografts remain at risk for chronic AMR and shortened survival. The optimum approach to treatment for chronic AMR remains to be determined...
  95. ncbi p38 Mitogen-activated protein kinase activation and cell localization in human glomerulonephritis: correlation with renal injury
    Cosimo Stambe
    Department of Nephrology and Monash University Department of Medicine, Melbourne, Australia
    J Am Soc Nephrol 15:326-36. 2004
    ..It was postulated that p38 MAPK is important in the pathogenesis of human glomerulonephritis and contributes to the development of renal injury...
  96. pmc Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 110:955-63. 2002
    ..identified in the circulation of approximately 80% of patients with pauci-immune necrotizing and crescentic glomerulonephritis and systemic small vessel vasculitis, such as microscopic polyangiitis and Wegener granulomatosis...
  97. ncbi Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 30:621-6. 2007
    ..study compared the chronic effects of efonidipine and amlodipine on proteinuria in patients with chronic glomerulonephritis. The study subjects were 21 chronic glomerulonephritis patients presenting with spot proteinuria greater ..
  98. ncbi Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma
    Izaya Nakaya
    Department of Internal Medicine, Kanazawa Municipal Hospital, Kanazawa
    Intern Med 43:102-5. 2004
    ..In addition, crescent formations and immune complexes in glomeruli were observed. We report the first case of GIST complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
  99. ncbi Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis
    Adrian Schreiber
    Department of Nephrology and Hypertension, Medical Faculty of the Charite, Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Schwanebecker Chaussee 50, Berlin, Germany
    Kidney Int 77:118-28. 2010
    Antineutrophil cytoplasmic autoantibodies (ANCA) are associated with necrotizing crescentic glomerulonephritis (NCGN) and systemic vasculitis...
  100. ncbi Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation
    D A Mitchell
    Rheumatology Section and Department of Histopathology, Hammersmith Campus, Imperial College School of Medicine, London, United Kingdom
    J Immunol 162:5676-9. 1999
    C1q-deficient (C1qa-/-) mice develop antinuclear Abs and glomerulonephritis (GN) characterized by multiple apoptotic bodies...
  101. ncbi Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis
    T Matthew Eison
    Division of Pediatric Nephrology, Department of Pediatrics, University of Tennessee Health Science Center, and Children s Foundation Research Center at Le Bonheur Children s Medical Center, 50 North Dunlap, Memphis, TN 38103, USA
    Pediatr Nephrol 26:165-80. 2011
    Post-streptococcal acute glomerulonephritis (PSAGN) is one of the most important and intriguing conditions in the discipline of pediatric nephrology...

Research Grants75

  1. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    ..Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by immune complex glomerulonephritis and infiltration of activated macrophages into the glomerulus...
  2. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..lupus), a prototypical autoimmune disease affecting 300,000 Americans and often associated with glomerulonephritis and kidney failure, is increased by occupational exposure (e.g...
  3. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2013
    ..The mice exhibit markedly positive ANAs, anti-dsDNA titers, high circulating immunoglobulin levels, and glomerulonephritis. The spleens and lymph nodes are characterized by the persistence of high levels of apoptotic bodies in ..
  4. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..response in acute kidney injury following ischemia-reperfusion, nephrotoxins, transplantation, acute glomerulonephritis and rhabdomyolysis as well as several non-renal settings of injury...
  5. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2013
    ..for tissue damage by anti-phospholipid antibodies in NZW/BXSB F1 (W/B) mice that develop both proliferative glomerulonephritis and anti-phospholipid syndrome...
  6. FEASIBILITY OF REPAIRING GBM DEFECTS IN VIVO
    Jeffrey H Miner; Fiscal Year: 2012
    ..cause human kidney disease: mutations that affect the collagen IV chains cause Alport syndrome (hereditary glomerulonephritis), and those that affect laminin beta2 (LAMB2) cause Pierson syndrome/congenital nephrotic syndrome...
  7. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..for Mac-1 on neutrophils in two additional complement dependent models, bullous pemphigoid and thrombotic glomerulonephritis. The current application builds on these discoveries...
  8. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J J FERNANDES; Fiscal Year: 2012
    ..Its clinical features include glomerulonephritis, cardiovascular disease (CVD), skin rashes, serositis, hemolytic anemia, impairment of the central nervous ..
  9. Caspase 8: A Novel Suppressor of Dendritic Cell-Mediated Autoimmunity
    Carla M Cuda; Fiscal Year: 2013
    ..CreCD11cCasp8flox/flox mice display splenomegaly, lymphadenopathy, dsDNA-reactive autoantibodies, glomerulonephritis, immune complex deposition in the kidney, exacerbated proteinuria levels, heightened amounts of serum pro-..
  10. The role of cell death in Lupus Nephritis
    Roberto Caricchio; Fiscal Year: 2013
    ..cell death, the ultimate cell damage, has been recognized as a fundamental pathogenic mechanism in lupus glomerulonephritis (GN). GN is among the most devastating effects of lupus disease...
  11. B cell metabolism in activation and autoantibody production
    Jeffrey C Rathmell; Fiscal Year: 2013
    ..SLE-associated pathologies, including immune complex formation and deposition responsible for vasculitis and glomerulonephritis, many therapeutic approaches to treat SLE have targeted B cell survival or function...
  12. Progesterone &Estrogen Differentially Regulate DC Function in Lupus Autoimmunity
    Grant Hughes; Fiscal Year: 2012
    ..TC) model closely reconstitutes the NZB/W phenotype of female-predominant anti-dsDNA Abs, glomerulonephritis and mortality...
  13. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2009
    ..for tissue damage by anti-phospholipid antibodies in NZW/BXSB F1 (W/B) mice that develop both proliferative glomerulonephritis and anti-phospholipid syndrome...
  14. Immune and genetic determinants of murine glomerulonephritis
    Elahna Paul; Fiscal Year: 2012
    ..C57BL/6 (B6) mice with genetic ablation of CD48 (B6.CD48-/-) develop autoimmunity with severe glomerulonephritis (CD48GN) that is reminiscent of human systemic lupus erythematosus...
  15. Macrophage Infiltration of Renal Tissue via beta-3 Integrins and Agrin
    Scott D Blystone; Fiscal Year: 2013
    b>Glomerulonephritis is most commonly an autoimmune-induced inflammatory event wherein infiltration of the kidney by macrophages results in loss of renal function due to fibrosis...
  16. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2013
    ..immune complexes (IC) in tissues underlies the pathogenesis of a range of human autoimmune diseases from glomerulonephritis, SLE and arthritis, to transplantation rejection...
  17. MicroRNA expression in the NZB/W lupus mouse
    CHRISTOPHER MICHAEL REILLY; Fiscal Year: 2013
    ..cells from NZB/W female mice will show an altered miRNA profile in the initiation and progression of glomerulonephritis and that immunosuppressive agents used in the therapeutic management of SLE act to correct disease, in part, ..
  18. Genetic control of renal disease in lupus-prone mice
    Marcia McDuffie; Fiscal Year: 2010
    We have identified a susceptibility locus for lupus-associated chronic glomerulonephritis using congenic mouse strains that replace segments of distal chromosome (Chr) 4 in the lupus-prone NZM2328 (NZM) strain with those from the ..
  19. B CELL HYPERACTIVITY IN AUTOIMMUNITY
    Ann Marshak Rothstein; Fiscal Year: 2010
    ..can deposit in blood vessel walls, glomeruli, and joints and contribute to complications ranging from glomerulonephritis to coagulation disorders...
  20. Cross-Talk Between Estrogen and T Cells Mediated Pathways in Lupus Pathogenesis
    Alessandra B Pernis; Fiscal Year: 2010
    ..effector T cells and IgG+ B cells, profound hypergammaglobulinemia, autoantibody production, proteinuria and glomerulonephritis. Like human SLE, development of these manifestations primarily affects the female gender...
  21. Role of innate responses to viruses in the genesis of IgA Nephropathy
    Steven N Emancipator; Fiscal Year: 2012
    ..will provide insight to the mechanisms of pathogenesis and progression of IgA nephropathy, a common form of glomerulonephritis that affects Veterans and leads (in ~30% of patients) to end stage renal disease...
  22. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2013
    ..Despite significant progress, immune mediated glomerulonephritis (GN) remains a major cause of end stage renal failure...
  23. PATHOGENESIS OF AUTOANTIBODIES IN PRISTANE-INDUCED LUPUS
    Westley H Reeves; Fiscal Year: 2013
    ..TMPD, pristane), anti-Sm/RNP and anti-DNA autoantibodies are induced and immune complex-mediated glomerulonephritis develops...
  24. Molecular pathogenesis of anti-glomerular basement membrane nephritis
    Dorin Bogdan Borza; Fiscal Year: 2012
    ..is an essential part of the blood filtration barrier and the primary site of injury in aggressive forms of glomerulonephritis mediated by anti-GBM antibodies...
  25. Role of Autoreactivity in Pathogenesis of Chronic GVHD
    Defu Zeng; Fiscal Year: 2013
    ..DBA/2 donors to BALB/c hosts, in which the recipients developed high serum levels of autoantibodies, glomerulonephritis, and scleroderma-like skin damage...
  26. Mechanism of Renal Cell Injury
    Goutam Ghosh Choudhury; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A major manifestation of mesangioproliferative glomerulonephritis in human and experimental model is increased expression of platelet-derived growth factor receptor-2 (PDGFR) in mesangial cells with ..
  27. Interplay of Innate and Adaptive Immunity in Lupus Pathogenesis
    Michelle L Hermiston; Fiscal Year: 2013
    ..hybrid 129-C57Bl/6 (B6) background, CD45E613R mice develop anti-dsDNA antibodies and immune complex-mediated glomerulonephritis (GN)...
  28. Altered miRNA expression in mesangial cells in lupus mice
    CHRISTOPHER MICHAEL REILLY; Fiscal Year: 2011
    ..cells from NZB/W female mice will show an altered miRNA profile in the initiation and progression of glomerulonephritis. To test our hypothesis we propose the following Specific Aim: Specific Aim 1: Define the expression profile ..
  29. Regulation of inflammatory responses by nucleic-acid binding polymers
    EDUARTA K HOLL; Fiscal Year: 2013
    ..For example, inhibition of TLR7 and 9 results in reduced inflammation and glomerulonephritis, a hallmark of SLE...
  30. Characterization of microRNA-regulated signaling pathways in mouse SLE
    Marianthi Kiriakidou; Fiscal Year: 2013
    ..Sle123. Autoimmune disease in B6.Sle123 is characterized by autoantibodies, lymphosplenomegaly and glomerulonephritis, strongly resembling human lupus. We studied the expression of miRNAs in B6...
  31. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
    Progressive kidney disease is characterized by the accumulation of fibrotic mediators in the kidney. Glomerulonephritis, diabetic nephropathy, pyelonephritis, and renovascular disease together account for over 75% of patients requiring ..
  32. Targeted delivery of TGFbeta blockade to diseased glomeruli
    Yufeng Huang; Fiscal Year: 2010
    ..in glomerular mesangial cells will ameliorate the progression of matrix expansion in experimental glomerulonephritis. Our long-term goal is to develop the mesangial cell- targeting nanoparticle-based siRNA as novel molecular ..
  33. Genetic Basis of Non-Familial IgA Nephropathy
    Tongzhong Ju; Fiscal Year: 2012
    ..Primary IgAN is the most common form of primary glomerulonephritis, leading to progressive renal failure in almost one third of the patients...
  34. Reduction of kidney progressive fibrosis by A2A adenosine receptor activation: P
    Gabriela E Garcia; Fiscal Year: 2013
    ..Crescentic glomerulonephritis (GN) is a severe and rapidly progressive glomerular disease with a poor prognosis...
  35. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): IgA nephropathy (IgAN) is the most common primary glomerulonephritis and an important cause of end-stage kidney failure...
  36. HUMAN PROTEOLYTIC FOR IgA NEPHROPATHY
    Robert F Balint; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis worldwide...
  37. Integrative Biology of Childhood Kidney Disease
    ELLIS DAVID AVNER; Fiscal Year: 2011
    ..of disease progression and tubulointerstitial fibrosis in diabetic nephropathy, focal segmental sclerosing glomerulonephritis, hypertension, and any primary renal disease which leads to nephron loss...
  38. Tertiary lymphoid neogenesis in human lupus nephritis
    Marcus R Clark; Fiscal Year: 2012
    ..Of the pathological manifestations of LN, glomerulonephritis (GN) is both the best studied and the feature most often replicated in murine models of autoimmune disease...
  39. Fourth Dense Deposit Disease Focus Group Meeting
    Richard J H Smith; Fiscal Year: 2011
    ..advances in our understanding of the pathophysiology of C3-glomerulopathies, which include DDD and primary glomerulonephritis with C3 deposits (GN-C3); 2...
  40. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): IgA nephropathy (IgAN) is the most common primary glomerulonephritis and an important cause of end-stage kidney failure...
  41. Defining genetic pathways to severe systemic autoimmunity
    Edward K Wakeland; Fiscal Year: 2010
    ..SIe1Sle3 or B6.S/e7S/e5 bi-congenics) will drive the development of severe systemic autoimmunity and fatal glomerulonephritis. The overall goal of this project will be to identify the gene or genes responsible for the S/e3 and S/e5 ..
  42. Endogenous RNA Ligands For Toll-like Receptors In Immune-Complex Nephritis
    Ramon G B Bonegio; Fiscal Year: 2013
    ..The resulting kidney inflammation or glomerulonephritis is often destructive and progresses over time to end-stage kidney failure that requires dialysis or ..
  43. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald J Falk; Fiscal Year: 2013
    b>Glomerulonephritis and vasculitis caused by anti-neutrophil cytoplasmic autoantibodies (ANCA) Is the most common form of rapidly progressive glomerular disease...
  44. A critical role of TAM receptors in autoimmune nephritis
    Wenhai Shao; Fiscal Year: 2013
    ..has been a useful model that produces pathological changes similar to those seen in immune-mediated glomerulonephritis. Using this model, we found an important protective role for Mer...
  45. Cellular Regulation of Dictyostelium Myosin Heavy Chain Kinases
    Paul A Steimle; Fiscal Year: 2012
    ..of how defects in human myosin II bipolar filament turnover can lead to abnormal platelet formation, glomerulonephritis, among other pathologies associated with MYH9-related disorders...
  46. Molecular mechanisms of the impact of Fli-1 on lupus
    Xian Zhang; Fiscal Year: 2013
    ..SLE) is a prototypic autoimmune disease characterized by arthritis, vasculitis, immune complex glomerulonephritis and infiltration of inflammation cells into the glomeruli...
  47. The Quality of Care in Evaluating Patients Suspected of Having Bladder Cancer
    Daniel A Barocas; Fiscal Year: 2013
    ..disease such as kidney stones (nephrolithiasis), urinary tract infection;or intrinsic renal disease, such as glomerulonephritis. The proper evaluation of patients with hematuria is essential to identify the 1 person in 10 who may have a ..
  48. Regulation of Podocyte Actin Cytoskeleton
    Puneet Garg; Fiscal Year: 2012
    ..2 percent of medicare spending (21.3 billion dollars). Diabetic nephropathy and glomerulonephritis contributes about 56.5 percent of the incident patients on dialysis...
  49. Development of Complement Modulating Therapeutics for AMD
    Gregory S Hageman; Fiscal Year: 2010
    ..macular degeneration (AMD), the most common cause of blindness worldwide, and for membranoproliferative glomerulonephritis type II (MPGN II), a renal disease characterized by ocular features that are indistinguishable from those ..
  50. Immunoglobulin Receptors and Immune Complex Processing in the Kidney
    Scott E Wenderfer; Fiscal Year: 2013
    ..mechanisms of accumulation and clearance is essential for accurately diagnosing and treating these forms of glomerulonephritis. CD300g is a novel immune complex receptor expressed on endothelial cells...
  51. Phosphatases in Human Lupus
    George C Tsokos; Fiscal Year: 2013
    ..Finally, a novel mouse over expressing PP2Ac in T cells produces increased amounts of IL-17 and is prone to glomerulonephritis. The hypothesis that PP2Ac represents a main contributor in the immunopathogenesis of SLE will be tested by ..
  52. Lupus Glomenulonephritis and NK T cells
    Samuel Strober; Fiscal Year: 2013
    Systemic lupus is an autoimmune disease that results in immune complex glomerulonephritis in NZB/W mice and humans...
  53. Quantitative Genetics of Defective IgA1 Glycosylation in IgA Nephropathy
    Krzysztof Kiryluk; Fiscal Year: 2013
    ..IgA nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. Most IgAN patients exhibit a characteristic under-glycosylation of the IgA1 molecule...
  54. Modified Human Anti-a(3) IV Antibodies for Drug Delivery in Nephritis
    Michael P Madaio; Fiscal Year: 2010
    ..a major advantage of this approach and technology is that it will have application to all forms of glomerulonephritis. Furthermore, since the reagents are derived from human Ab sequences, they have the potential of being ..
  55. Inflammation in Vascular Injury and Repair
    Daniel I Simon; Fiscal Year: 2013
    ..that the Mac-1-GP Iba interaction broadly regulates inflammation in models of thrombosis, vasculitis, glomerulonephritis, and multiple sclerosis...
  56. A GWAS for IgA Nephropathy, the Most Common form of Glomerulonephritis
    Richard P Lifton; Fiscal Year: 2010
    ..It is the most common cause of kidney failure among Asian populations, and the most common form of primary glomerulonephritis among young Caucasians...
  57. Novel Receptor-Ligand Interactions in Glomerulonephritis
    Mary H Foster; Fiscal Year: 2013
    ..The model will also generate unique human immune reagents and tools, with the ultimate goal of providing a platform for preclinical testing to validate research findings and to test immune modulating interventions in vivo. ..
  58. Urinary Polypeptide Biomarkers of IgA Nephropathy
    Jan Novak; Fiscal Year: 2010
    ..Relevance: IgAN is the most common primary glomerulonephritis worldwide...
  59. Role of CD48:CD244 Pathway in Systemic Lupus Erythematosus
    DANIEL RABIN BROWN; Fiscal Year: 2013
    ..were bred to the Y-linked autoimmune accelerator locus (Yaa), the resulting strain developed proliferative glomerulonephritis, in marked contrast to Yaa mice that do not develop renal disease...
  60. IgA1 glycosylation and receptor interactions in IgA nephropathy
    Andrew B Herr; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): IgA nephropathy (IgAN) is the most common form of glomerulonephritis, an inflammatory disease of the kidney...
  61. Population-based study of serum IgA, IgA1, and galactose-deficient IgA1 levels
    Krzysztof Kiryluk; Fiscal Year: 2013
    ..IgAN is the most common form of primary glomerulonephritis worldwide and progresses to end-stage renal disease in up to 40% of cases...
  62. Lupus and the inhibitory dual receptor hypothesis
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2013
    ..also study their immune modulatory properties on the in vivo disease activity in murine models of autoimmune glomerulonephritis. Moreover, to investigate the relevance to clinical disease, we will also assess whether there is a ..
  63. 2011 ASN Program for Medical Students and Residents
    Donald E Kohan; Fiscal Year: 2012
    ..bone and mineral metabolism, cell and transport physiology, chronic kidney disease, development, dialysis, glomerulonephritis, hypertension and cardiovascular disease, novel translational approaches, pathology, renal cystic diseases, ..
  64. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Adapted from Investigator's Abstract): Anti-GBM disease in humans is associated with rapidly progressive glomerulonephritis, anti-a3(IV)NC1 collagen antibodies, and sometimes pulmonary hemorrhage...
  65. Prediction of Lupus Outcome by Gene Expression Patterns
    Robert Winchester; Fiscal Year: 2006
    ..studies to define the gene expression profiles of glomeruli isolated from biopsy sections of lupus glomerulonephritis with the overall goals of determining whether the glomerular gene expression phenotype will predict outcome ..
  66. STREPTOCOCCAL HYALURONATE CAPSULE
    Ivo van de Rijn; Fiscal Year: 1999
    ..a variety of severe suppurative infections, as well as non-suppurative sequelae such as post-streptococcal glomerulonephritis and rheumatic fever...
  67. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..immune-mediated arthritis, diabetes, inflammatory bowel diseases, systemic lupus erythematosus (SLE), glomerulonephritis, vasculitis, atherosclerosis and asthma, a major impediment to their diagnosis and clinical management is ..
  68. Specialized Center of Research in Systemic Lupus Erythe*
    Shu Man Fu; Fiscal Year: 2006
    ..have led to the identification of new SLE susceptibility loci, the distinction between acute and chronic glomerulonephritis, and most importantly the dissociation of ANA, anti-dsDNA and anti-nucleosome antibody production from ..
  69. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..proliferation and migration, phenotypes manifest in many glomerular diseases including mesangioproliferative glomerulonephritis (GN)...
  70. Inhibition of lupus nephritis in IRF-1 deficient mice
    Christopher Reilly; Fiscal Year: 2003
    MRL/Ipr mice spontaneously develop immune complex glomerulonephritis similar to human lupus...
  71. ROLE OF ANTI-PROTEINASE-3 IN WEGENER'S VASCULOPATHY
    Judith James; Fiscal Year: 2003
    ..disease of unknown etiology which is characterized by small to medium vessel vasculitis, pauci-immune glomerulonephritis, necrosis/granuloma formation of the respiratory tracts and autoantibodies to neutrophilic components...
  72. NOVEL INFLAMMATORY MEDIATORS IN GLOMERULONEPHRITIS
    Elias Lianos; Fiscal Year: 1992
    ..aforementioned mediators on renal hemodynamic perturbations occurring following induction of experimental glomerulonephritis in the rat...
  73. Human Autoantibodies in Anti-GBM Disease
    Anne Christensen; Fiscal Year: 2005
    ..The usual clinical picture is rapidly progressive glomerulonephritis (RPGN) resulting in end stage renal disease...
  74. EXPRESSION OF TRANSGENIC TCR GENES IN AUTOIMMUNE 1PR/1PR
    JOHN MOUNTZ; Fiscal Year: 1993
    ..and autoimmune disease characterized by hypergammaglobulinemia, autoantibody production, arthritis and glomerulonephritis. The lpr gene has not been mapped and is defined only by the autoimmune phenotype...
  75. Accurate profiles of IgA1 O-glycan heterogeneity in IgA nephropathy
    MATTHEW RENFROW; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): IgA nephropathy (IgAN) is the most common form of glomerulonephritis in the world and is a leading cause of end-stage renal disease...