renal glycosuria

Summary

Summary: Glycosuria occurring when there is only the normal amount of sugar in the blood, due to inherited inability of the renal tubules to reabsorb glucose completely. (Dorland, 27th ed)

Top Publications

  1. ncbi Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    L P van den Heuvel
    Department of Pediatrics, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Genet 111:544-7. 2002
  2. ncbi Phlorizin: a review
    Joel R L Ehrenkranz
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Diabetes Metab Res Rev 21:31-8. 2005
  3. ncbi Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Diabetes Obes Metab 11:79-88. 2009
  4. ncbi SGLT2 inhibition--a novel strategy for diabetes treatment
    Edward C Chao
    Section of Endocrinology, Metabolism and Diabetes, VA San Diego Healthcare System and University of California, San Diego School of Medicine, 3350 La Jolla Village Drive, 111 G San Diego, California 92161, USA
    Nat Rev Drug Discov 9:551-9. 2010
  5. ncbi [Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus]
    Didac Mauricio
    Servicio de Endocrinologia y Nutricion, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España Electronic address
    Med Clin (Barc) 141:31-5. 2013
  6. ncbi [Vesical uric acid lithiasis in a child with renal hypouricemia]
    E Martin Hernandez
    Unidad de Nefrologia, Hospital de San Rafael, Madrid, Spain
    An Esp Pediatr 55:273-6. 2001
  7. ncbi Pregnancy-associated polyuria in familial renal glycosuria
    Hakan R Toka
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA Division of Nephrology, Brigham and Women s Hospital, Boston, MA
    Am J Kidney Dis 62:1160-4. 2013
  8. ncbi Reversible renal glycosuria in acute interstitial nephritis
    Chok Limsuwat
    Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Am J Med Sci 344:245-7. 2012
  9. pmc Life-threatening hypophosphataemia in a cirrhotic patient with jaundice
    Elisavet Moutzouri
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Arch Med Sci 7:736-9. 2011
  10. ncbi High blood glucose and osmolality, but not high urinary glucose and osmolality, affect neuronal nitric oxide synthase expression in diabetic rat kidney
    Ming Chia Hsieh
    Department of Internal Medicine, Kaohsiung Medical University, Taiwan
    J Lab Clin Med 141:200-9. 2003

Research Grants

  1. FAMILIAL GLUCOSE GALACTOSE MALABSORPTION
    ERNEST WRIGHT; Fiscal Year: 2001
  2. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications65

  1. ncbi Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    L P van den Heuvel
    Department of Pediatrics, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Genet 111:544-7. 2002
    ..Our data provide the first direct evidence of an etiologic role for the sodium/glucose cotransporter type 2 in the pathogenesis of renal glucosuria...
  2. ncbi Phlorizin: a review
    Joel R L Ehrenkranz
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Diabetes Metab Res Rev 21:31-8. 2005
    ..Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the ..
  3. ncbi Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Diabetes Obes Metab 11:79-88. 2009
    ..The observation that individuals with familial renal glycosuria maintain normal long-term kidney function provides some reassurance that this mode of action will not ..
  4. ncbi SGLT2 inhibition--a novel strategy for diabetes treatment
    Edward C Chao
    Section of Endocrinology, Metabolism and Diabetes, VA San Diego Healthcare System and University of California, San Diego School of Medicine, 3350 La Jolla Village Drive, 111 G San Diego, California 92161, USA
    Nat Rev Drug Discov 9:551-9. 2010
    ..Genetic mutations in the kidney-specific SGLT2 isoform that result in benign renal glycosuria, as well as preclinical and clinical studies with SGLT2 inhibitors in type 2 diabetes, support the potential ..
  5. ncbi [Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus]
    Didac Mauricio
    Servicio de Endocrinologia y Nutricion, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España Electronic address
    Med Clin (Barc) 141:31-5. 2013
    ..This article discusses the basic features of this new treatment concept and the efficacy and safety of this new drug group. ..
  6. ncbi [Vesical uric acid lithiasis in a child with renal hypouricemia]
    E Martin Hernandez
    Unidad de Nefrologia, Hospital de San Rafael, Madrid, Spain
    An Esp Pediatr 55:273-6. 2001
    ..These findings were consistent with a presecretory defect. No other tubular dysfunctions, such as renal glycosuria, aminoaciduria or phosphaturia were found...
  7. ncbi Pregnancy-associated polyuria in familial renal glycosuria
    Hakan R Toka
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA Division of Nephrology, Brigham and Women s Hospital, Boston, MA
    Am J Kidney Dis 62:1160-4. 2013
    ..amino acid 168 and leading to premature termination of the protein at amino acid 186) diagnostic of familial renal glycosuria. Pregnant women with familial renal glycosuria can be at risk of profound polyuria during pregnancy due to ..
  8. ncbi Reversible renal glycosuria in acute interstitial nephritis
    Chok Limsuwat
    Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Am J Med Sci 344:245-7. 2012
    b>Renal glycosuria is defined as the excretion of glucose in urine in a normoglycemic state. It results from renal tubular dysfunction or immaturity of tubular function in the newborn...
  9. pmc Life-threatening hypophosphataemia in a cirrhotic patient with jaundice
    Elisavet Moutzouri
    Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
    Arch Med Sci 7:736-9. 2011
    ..7 mg/dl [101 µmol/l]) with renal uric acid wasting and renal glycosuria. This generalized proximal tubular defect may occasionally be seen in deeply jaundiced patients...
  10. ncbi High blood glucose and osmolality, but not high urinary glucose and osmolality, affect neuronal nitric oxide synthase expression in diabetic rat kidney
    Ming Chia Hsieh
    Department of Internal Medicine, Kaohsiung Medical University, Taiwan
    J Lab Clin Med 141:200-9. 2003
    ..Phlorizin, a competitive inhibitor of glucose transport in the proximal tubule, causes renal glycosuria in nondiabetic rats and reverses hyperglycemia in diabetic rats...
  11. ncbi Transient proximal tubular renal injury following Ecstasy ingestion
    Charles Kwon
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Pediatr Nephrol 18:820-2. 2003
    ..evaluation revealed hyponatremia (Na 117 mEq/L), polyuria (urine output >400 mL/h for several hours), renal glycosuria (blood glucose 120 mg/dL, urine glucose >1,000 mg/dL), and solute diuresis (urine osmolality 552 mOsm/kg H2O)...
  12. ncbi [Problems in the diagnosis of gestational diabetes]
    A Adamikova
    Interni klinika IPVZ, Zlin
    Vnitr Lek 47:777-80. 2001
    ..19 patients with gestational diabetes were detected, 6 with impaired glucose tolerance and 18 with renal glycosuria. During the investigation no patient was detected with negative screening and subsequently confirmed ..
  13. ncbi [Renal glycosuria: report of two cases]
    Joana Chaves Rebelo
    Centro Hospitalar do Médio Ave CHMA, Unidade de Famalicão, Portugal
    J Bras Nefrol 34:291-2. 2012
    ..The genetic study confirmed the diagnosis of renal glycosuria, by revealing SCL5A2 gene mutations...
  14. ncbi Fanconi's syndrome and distal (type 1) renal tubular acidosis in a patient with primary Sjögren's syndrome with monoclonal gammopathy of undetermined significance
    T Kobayashi
    Department of Nephrology, Jichi Medical School, Shimotsuke, Tochigi, Japan
    Clin Nephrol 65:427-32. 2006
    ..Further studies revealed proximal tubular dysfunction, including renal glycosuria, generalized aminoaciduria, phosphaturia, uricosuria and proximal RTA...
  15. ncbi Renal tubular function in children with beta-thalassemia minor
    Suleyman Kalman
    Division of Pediatric Nephrology, Gulhane Military Medical Faculty, Ankara, Turkey
    Nephrology (Carlton) 10:427-9. 2005
    ..Our aim was to investigate the renal tubular functions in children with beta-thalassemia minor and to determine its possible harmful effects...
  16. ncbi Renal glycosuria: occurrence in two siblings and a review of the literature
    Aaron Friedman
    Department of Pediatrics, Brown Medical School, Providence, RI 02903, USA
    J Pediatr 147:639. 2005
  17. ncbi [Juvenile cataract associated with microcornea and glucosuria: a new syndrome]
    K Vandekerckhove
    Augenklinik, Kantonsspital Luzern, Schweiz
    Klin Monbl Augenheilkd 224:344-6. 2007
    ..Predisposition is responsible for approximately 50% of age-related cataracts. Investigation of inherited forms of cataract provides the opportunity to identify the genes that may play a role in age-related cataract as well...
  18. ncbi Massive immune hemolysis caused by anti-D after dual kidney transplantation
    Gregory J Pomper
    Department of Pathology, Wake Forest University School of Medicine and North Carolina Baptist Hospital, Winston Salem, NC, USA
    Am J Transplant 5:2586-9. 2005
    ..Transfusion support subsided after two months. If complications of anemia can be avoided, the deleterious effects of hemolysis may be well tolerated by renal allografts using antigen negative transfusion alone...
  19. ncbi A clinical and molecular genetic study of hypophosphatemic rickets in children
    Hee Y Cho
    Department of Pediatrics, Seoul National University Children s Hospital, Seoul 110 744, Korea
    Pediatr Res 58:329-33. 2005
    ..b>Renal glycosuria was detected in six cases and was associated with more severe skeletal disease...
  20. ncbi A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria
    Daniella Magen
    Pediatric Nephrology Unit, Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Kidney Int 67:34-41. 2005
    ..The purpose of this study was to examine the phenotypic and genetic characteristics of three unrelated consanguineous families with FRG accompanied by aminoaciduria...
  21. ncbi A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria
    Jean Francis
    Department of Internal Medicine, Hospital of St Raphael, CT, USA
    Nephrol Dial Transplant 19:2893-5. 2004
  22. ncbi Gene Symbol: SLC55A2. Disease: familial renal glucosuria
    J Calado
    Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal
    Hum Genet 115:170. 2004
  23. ncbi Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting
    J Calado
    Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, Rua da Junquiera no 96, 1349 008 Lisbon, Portugal
    Kidney Int 69:852-5. 2006
    ..Definite proof of renin-angiotensin aldosterone system activation in FGR should rely on evaluation of additional patients with massive glucosuria...
  24. ncbi [Disorders of renal tubular transport of amino acids, hexose and phosphate]
    Hajime Hasegawa
    Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical School
    Nihon Rinsho 64:522-7. 2006
  25. ncbi Biology of human sodium glucose transporters
    Ernest M Wright
    Department of Physiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1751, USA
    Physiol Rev 91:733-94. 2011
    ..We also discuss the physiology and pathophysiology of SGLTs, e.g., glucose galactose malabsorption and familial renal glycosuria, and briefly report on targeting of SGLTs for new therapies for diabetes.
  26. ncbi The Na(+)/glucose cotransporters: from genes to therapy
    R Sabino-Silva
    Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 43:1019-26. 2010
    ..caused by aberrant expression of the SGLT1 in glucose-galactose malabsorption and the SGLT2 in familial renal glycosuria. Finally, it covers some pharmacological compounds that are being currently studied focusing on the interest ..
  27. pmc Heterogeneous stock rats: a new model to study the genetics of renal phenotypes
    Leah C Solberg Woods
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 298:F1484-91. 2010
    ....
  28. ncbi Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor
    Murugesan Ram Prabahar
    Department of Nephrology, Sri Ramachandra Medical College, Sri Ramachandra University, Chennai, Tamilnadu, India
    Saudi J Kidney Dis Transpl 19:964-8. 2008
    ..magnesium wasting, decreased tubular absorption of phosphorus, hypo-uricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have been described even in patients with beta thalassemia minor...
  29. ncbi Can we generate new hypotheses about Dent's disease from gene analysis of a mouse model?
    Sandra E Guggino
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Exp Physiol 94:191-6. 2009
    ..The sodium-proton exchanger-like protein, Nhe10/sperm, encoded by Slc9a10, has a 0.5-fold decrease in transcript number. These genes are discussed with regard to the possible physiological outcomes of their transcript or protein changes...
  30. ncbi Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2
    Bruce A Ellsworth
    Research and Development, Bristol Myers Squibb Co, PO Box 5400, Princeton, NJ 08543 5400, USA
    Bioorg Med Chem Lett 18:4770-3. 2008
    ..The lead C-arylglucoside (7a) demonstrates superior metabolic stability to its O-arylglucoside counterpart (4) and it promotes glucosuria when administered in vivo...
  31. ncbi Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion
    Joaquim Calado
    Departamento de Genética da Faculdade de Ciências Médicas, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal
    Nephrol Dial Transplant 23:3874-9. 2008
    ..We have now extended this analysis to another 21 consecutive cases from 17 pedigrees, including 11 cases with severe glucose excretion...
  32. pmc Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria
    Barbara Kloeckener-Gruissem
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University Zurich, CH 8603 Schwerzenbach, Switzerland
    Am J Hum Genet 82:772-9. 2008
    ..This report demonstrates biological relevance of this solute carrier. We hypothesize that SLC16A12 is important for lens and kidney homeostasis and discuss its potential role in age-related cataract...
  33. ncbi Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity
    H S Freitas
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05505 900 Sao Paulo, SP, Brazil
    Endocrinology 149:717-24. 2008
    ..in Na(+)-glucose transporters (SGLT)-2 and hepatocyte nuclear factor (HNF)-1alpha genes have been related to renal glycosuria and maturity-onset diabetes of the young 3, respectively...
  34. ncbi Transient renal tubulopathy in a racing Greyhound
    L A Abraham
    Department of Veterinary Science, The University of Melbourne, Werribee VIC 3030
    Aust Vet J 84:398-401. 2006
    ..Systemic hypertension, renal glucosuria and altered fractional excretion of electrolytes resolved during the 7 day period of hospital treatment. The Greyhound resumed training without recurrence of renal dysfunction...
  35. ncbi Long-term outcome of renal glucosuria type 0: the original patient and his natural history
    Sabine Scholl-Burgi
    Department of Pediatrics, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 19:2394-6. 2004
  36. ncbi Renal glucosuria due to SGLT2 mutations
    Robert Kleta
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 10, Room 10C 107, MSC 1851, 10 Center Drive, Bethesda, MD 20892 1851, USA
    Mol Genet Metab 82:56-8. 2004
    ..Here we present clinical and molecular data regarding a 19-year-old woman with isolated glucosuria. She was compound heterozygous for two SGLT2 mutations, i.e., a new missense mutation, T200K, and a known missense mutation, N654S...
  37. ncbi Autosomal recessive renal proximal tubulopathy and hypercalciuria: a new syndrome
    Daniella Magen
    Pediatric Nephrology Unit, Meyer Children s Hospital, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Kidney Dis 43:600-6. 2004
    ....
  38. ncbi Renal glycosuria treated as diabetes mellitus: case report
    J Orem
    Department of Medicine, Mulago Hospital, Kampala, Uganda
    East Afr Med J 74:740-2. 1997
    A case of renal glycosuria is reported. A 55 year old female was diagnosed and treated in an upcountry hospital for diabetes mellitus...
  39. ncbi Hypercalciuria in renal glucosuria
    S Kavukcu
    Department of Pediatrics, Dokuz Eylul University, Izmir, Turkey
    Acta Paediatr Jpn 38:72-4. 1996
    ..In this paper, we report on a case who has both renal glucosuria and hypercalciuria...
  40. ncbi Hyperoxaluria with hyperglycoluria not due to alanine:glyoxylate aminotransferase defect: a novel type of primary hyperoxaluria
    K J Van Acker
    Department of Pediatrics, University Hospital, Antwerp Belgium
    Kidney Int 50:1747-52. 1996
    ..Although the underlying defect leading to hyperoxaluria and hyperglycoluria could not be identified in these patients, it is probable that they represent a separate type of primary hyperoxaluria...
  41. ncbi Preventive effect of betamipron on nephrotoxicity and uptake of carbapenems in rabbit renal cortex
    Y Hirouchi
    Product Development Laboratory, Sankyo Co, Ltd, Tokyo, Japan
    Jpn J Pharmacol 66:1-6. 1994
    ..Because of the low toxicity of BP (LD50 in the rat, more than 3,000 mg/kg, i.v.), it was concluded that BP might be a good candidate for reducing the nephrotoxicity induced by panipenem or imipenem...
  42. ncbi Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28
    M Kambouris
    Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223
    Am J Med Genet 29:239-46. 1988
    ..01 (theta = 0) obtained for the molecular markers F8A (F8C) and DXS15 (DX13) respectively, indicate that the NDI gene is located in Xq28. A lod score of 3.61 (theta = 0) was obtained with multipoint linkage analysis of F8A and DXS15...
  43. ncbi Effect of camostat mesilate on heavy proteinuria in various nephropathies
    M Matsubara
    Renal Unit, Sendai Shakaihoken Hospital, Japan
    Clin Nephrol 32:119-23. 1989
    ....
  44. ncbi Changes in parathyroid hormone in diabetic patients on long-term hemodialysis
    K Kikunami
    Inoue Hospital, Suita, Japan
    Nephron 54:318-21. 1990
    ..In patients in both groups, the mean concentration of the mid-region of PTH increased significantly. Secondary hyperparathyroidism in HD/DM develops slower than in HD/non-DM...
  45. ncbi Juvenile nephronophthisis diagnosed from glucosuria detected by urine screening at school
    H Tsukahara
    Department of Pediatrics, Fukui Medical School, Japan
    Acta Paediatr Jpn 32:548-51. 1990
    ..On admission, she showed renal failure with combined proximal and distal tubular defects and progressive deterioration of renal function. JN should be considered in children with glucosuria...
  46. ncbi Type O renal glucosuria
    A Bagga
    Department of Paediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Acta Paediatr Scand 80:116-9. 1991
    ....
  47. ncbi Nephrotic proteinuria without hypoalbuminemia: clinical characteristics and response to angiotensin-converting enzyme inhibition
    M Praga
    Department of Nephrology, Hospital 12 de Octubre, Madrid, Spain
    Am J Kidney Dis 17:330-8. 1991
    ..1 +/- 2.4 to 8.8 +/- 4 g/d). Serum creatinine (Scr) remained stable during captopril treatment in group I, whereas three patients in group II showed a worsening of renal function.(ABSTRACT TRUNCATED AT 250 WORDS)..
  48. ncbi Glucose transporters
    L J Elsas
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322
    Annu Rev Med 43:377-93. 1992
    ..Molecular defects of different transporters of this class cause familial glucose-galactose malabsorption and renal glycosuria. In the basolateral membrane of epithelial cells and in nonepithelial cells, glucose flows down its ..
  49. pmc Is questionnaire information valid in the study of a chronic disease such as diabetes? The Nord-Trøndelag diabetes study
    K Midthjell
    National Institute for Public Health, Community Medicine Research Centre, Verdal, Norway
    J Epidemiol Community Health 46:537-42. 1992
    ..The aim was to validate information about diabetes mellitus collected by questionnaire in a large epidemiological survey...
  50. ncbi Hypercalciuria in children with renal glycosuria: evidence of dual renal tubular reabsorptive defects
    D Schneider
    Department of Pediatrics, Schneider Children s Hospital of Long Island Jewish Medical Center, New Hyde Park, New York 11042
    J Pediatr 121:715-9. 1992
    ..5 years, we have identified idiopathic hypercalciuria in five of seven patients referred for evaluation of renal glycosuria between 1985 and 1991. The children, all boys, ranged in age from 6 to 12 years...
  51. ncbi Transient renal glucosuria in patients with tetanus
    G R Rezaian
    Intensive Care Unit, Department of Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Nephron 80:292-5. 1998
    ..CONCLUSION: Significant but transient glucosuria of renal origin possibly induced by tetanospasmin is common in patients with tetanus...
  52. ncbi [Renal glucosuria and membranous glomerulonephritis in chronic inflammatory demyelinating polyradiculoneuropathy: CIDP]
    K Kanemoto
    Department of Pediatrics, Seinan Medical Center Hospital, Tsukuba University, Ibaraki, Japan
    Nippon Jinzo Gakkai Shi 41:511-6. 1999
    ..We surmise that chronic interstitial nephritis of insidious onset was followed by MGN which developed subsequently, probably at the time of the start of proteinuria...
  53. ncbi Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria
    Joaquim Calado
    Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, Rua da Junqueira 96, 1349 008 Lisbon, Portugal
    Hum Genet 114:314-6. 2004
    ..N654S mutation involving a highly conserved residue. These findings confirm that mutations in the SLC5A2 gene are responsible for recessive renal glucosuria...
  54. ncbi Molecular analysis of the SGLT2 gene in patients with renal glucosuria
    Rene Santer
    Department of Pediatrics, University of Kiel, Kiel, Germany
    J Am Soc Nephrol 14:2873-82. 2003
    ..We conclude that SGLT2 plays an important role in renal tubular glucose reabsorption. Inheritance of renal glucosuria shows characteristics of a codominant trait with variable penetrance...
  55. ncbi The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease
    Nina Zeh
    School of Medicine, University of Rostock, Germany
    Liver Int 23:34-8. 2003
    ..ECAD causes a transient increase in PLFA toward normal levels and also increases the proportion of n3 and n6 FA...
  56. ncbi The sodium/glucose cotransport family SLC5
    Ernest M Wright
    Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1751, USA
    Pflugers Arch 447:510-8. 2004
    ..Mutations in three genes produce genetic diseases (glucose-galactose malabsorption, renal glycosuria and hypothyroidism)...
  57. ncbi Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine
    Blanche M Chavers
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Nephrol 18:565-9. 2003
    ..06). At 5 years post Tx, recipients had a high prevalence of hyperlipidemia. The identification and treatment of hyperlipidemia should be included in pediatric kidney Tx protocols...
  58. ncbi Differential regulation of mouse kidney sodium-dependent transporters mRNA by cadmium
    N M Tabatabai
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    Toxicol Appl Pharmacol 177:163-73. 2001
    Chronic exposure to cadmium can result in renal glycosuria. Previously, we reported that cadmium reduced the relative abundance of the sodium-glucose cotransporter mRNA (Blumenthal et al., Toxicol. Appl. Pharmacol.149, 49-54, 1998)...
  59. ncbi Transient renal glycosuria in a patient with acute pyelonephritis
    C J Wu
    Division of Endocrinology and Metabolism of Internal Medicine, Chia Yi Veterans Hospital, Taiwan, ROC
    Intern Med 40:519-21. 2001
    ..Thus definite diagnosis of diabetes mellitus should be made only after recovery of APN by means of urinalysis or by simultaneous blood glucose concentration analysis...
  60. ncbi Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine
    S Sankarasubbaiyan
    Divisions of Nephrology and Internal Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Am J Kidney Dis 37:1039-43. 2001
    ..Future investigations could determine whether the syndrome involves a defect in the SGLT2 gene...
  61. ncbi Postprandial reactive hypoglycemia
    J F Brun
    Service Central de Physiologie Clinique, Centre d Exploration et de Réadaptation des Anomalies Métaboliques et Musculaires CERAMM, Lapeyronie Hospital Montpellier, France
    Diabetes Metab 26:337-51. 2000
    ..insulin response, either related to insulin resistance or to increased glucagon-like-peptide 1; (b) renal glycosuria; (c) defects in glucagon response; (d) high insulin sensitivity, probably the most frequent cause (50-70%), ..
  62. ncbi Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome
    O Sakamoto
    Department of Pediatrics, Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Pediatr Res 48:586-9. 2000
    ..Heterozygotes of L389P or V423E mutation from the patients' families showed renal glucosuria. These data suggested that GLUT2 gene defects may be a cause of renal glucosuria...
  63. ncbi Glucose transporters: structure, function and consequences of deficiency
    G K Brown
    Department of Biochemistry, Oxford, UK
    J Inherit Metab Dis 23:237-46. 2000
    ..of the secondary active sodium/glucose transporters result in glucose/galactose malabsorption or congenital renal glycosuria. GLUT1 deficiency produces a seizure disorder with low glucose concentration in cerebrospinal fluid and GLUT2 ..
  64. ncbi Serum fructosamine measurement: a new diagnostic approach to renal glucosuria in dogs
    S I Thoresen
    Department of Small Animal Clinical Sciences, The Norwegian School of Veterinary Science, Oslo, N 0033, Norway
    Res Vet Sci 67:267-71. 1999
    ..To distinguish between primary renal glucosuria and the Fanconi syndrome, measurement of the amino acid concentration in urine was performed...
  65. ncbi Angiotensin-converting enzyme inhibitors and glycosuria
    J J Milavetz
    Department of Internal Medicine, University of Arizona, Tucson 85724
    Arch Intern Med 152:1081-3. 1992
    b>Renal glycosuria associated with the use of angiotensin-converting enzyme inhibitors has been previously reported in two patients. A third patient was studied who developed isolated glycosuria associated with lisinopril therapy...

Research Grants2

  1. FAMILIAL GLUCOSE GALACTOSE MALABSORPTION
    ERNEST WRIGHT; Fiscal Year: 2001
    ..This study will enable us to identify and treat patients with sugar malabsorption due to mutations in the SGLT1 gene, and will provide unique information about the synthesis, trafficking and function of the cotransporter. ..
  2. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2005
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..