fanconi syndrome

Summary

Summary: Constellation of clinical and laboratory manifestations produced by generalized proximal tubular insufficiency in the presence of normal, or nearly normal, glomerular filtration.

Top Publications

  1. ncbi Urinary proteome pattern in children with renal Fanconi syndrome
    Jens Drube
    Department of Paediatric Nephrology, Children s Hospital, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 24:2161-9. 2009
  2. ncbi Fanconi syndrome due to deferasirox
    Cédric Rafat
    Universite Paris Descartes, Hopital Necker, APHP, Paris, France
    Am J Kidney Dis 54:931-4. 2009
  3. ncbi Acute renal failure and Fanconi syndrome due to deferasirox
    Steven Grangé
    Nephrology Department, Rouen University Hospital, 1 Avenue de Germont, 76031 Rouen Cedex, Rouen, France
    Nephrol Dial Transplant 25:2376-8. 2010
  4. ncbi A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice
    M S Sun
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    J Am Soc Nephrol 11:291-300. 2000
  5. pmc Genetic and physical mapping of the locus for autosomal dominant renal Fanconi syndrome, on chromosome 15q15.3
    U Lichter-Konecki
    Center for Medical Genetics, Marshfield Medical Research Foundation, Marshfield, WI, USA
    Am J Hum Genet 68:264-8. 2001
  6. ncbi Adult-onset acute tubulointerstitial nephritis and uveitis with Fanconi syndrome. Case report and review of the literature
    K Koike
    Department of Medicine, Division of Nephrology, Kurume University School of Medicine, Kurume, Japan
    Clin Nephrol 67:255-9. 2007
  7. pmc Acquired Fanconi's syndrome associated with tenofovir therapy
    George Mathew
    Division of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Gen Intern Med 21:C3-5. 2006
  8. ncbi Pamidronate-induced tubulointerstitial nephritis with Fanconi syndrome in a patient with primary hyperparathyroidism
    Martin Buysschaert
    Department of Endocrinology and Nutrition, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Bruxelles, Belgium
    Nephrol Dial Transplant 18:826-9. 2003
  9. ncbi Acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab
    Aisha Shaikh
    Wichita Nephrology Group, Wichita, KS, USA
    Ann Pharmacother 43:1370-3. 2009
  10. ncbi Fanconi syndrome and nephrogenic diabetes insipidus associated with didanosine therapy in HIV infection: a case report and literature review
    Géraldine D'Ythurbide
    Department of Nephrology, Kremlin Bicetre Hospital, AP HP, Le Kremlin Bicetre, France
    Nephrol Dial Transplant 22:3656-9. 2007

Detail Information

Publications196 found, 100 shown here

  1. ncbi Urinary proteome pattern in children with renal Fanconi syndrome
    Jens Drube
    Department of Paediatric Nephrology, Children s Hospital, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 24:2161-9. 2009
    The renal Fanconi syndrome (FS) is characterized by renal glucosuria, loss of electrolytes, bicarbonate and lactate, generalized hyperaminoaciduria and low-molecular-weight proteinuria...
  2. ncbi Fanconi syndrome due to deferasirox
    Cédric Rafat
    Universite Paris Descartes, Hopital Necker, APHP, Paris, France
    Am J Kidney Dis 54:931-4. 2009
    ..We report a case of Fanconi syndrome associated with acute renal insufficiency in a patient receiving deferasirox...
  3. ncbi Acute renal failure and Fanconi syndrome due to deferasirox
    Steven Grangé
    Nephrology Department, Rouen University Hospital, 1 Avenue de Germont, 76031 Rouen Cedex, Rouen, France
    Nephrol Dial Transplant 25:2376-8. 2010
    ..However, recent data from large studies confirmed the renal toxicity of deferasirox. We report a case of Fanconi syndrome associated with acute renal failure in a patient receiving deferasirox...
  4. ncbi A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice
    M S Sun
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    J Am Soc Nephrol 11:291-300. 2000
    ..Simultaneously, renal tubular function was impaired and Fanconi syndrome occurred...
  5. pmc Genetic and physical mapping of the locus for autosomal dominant renal Fanconi syndrome, on chromosome 15q15.3
    U Lichter-Konecki
    Center for Medical Genetics, Marshfield Medical Research Foundation, Marshfield, WI, USA
    Am J Hum Genet 68:264-8. 2001
    Autosomal dominant renal Fanconi syndrome is a genetic model for the study of proximal renal tubular transport pathology. We were able to map the locus for this disease to human chromosome 15q15...
  6. ncbi Adult-onset acute tubulointerstitial nephritis and uveitis with Fanconi syndrome. Case report and review of the literature
    K Koike
    Department of Medicine, Division of Nephrology, Kurume University School of Medicine, Kurume, Japan
    Clin Nephrol 67:255-9. 2007
    We report a case of tubulointerstitial nephritis and uveitis (TINU syndrome) with full type Fanconi syndrome. A 32-year-old woman presented with fatigue, anorexia and weight loss...
  7. pmc Acquired Fanconi's syndrome associated with tenofovir therapy
    George Mathew
    Division of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Gen Intern Med 21:C3-5. 2006
    ..Frequent urine, renal, and electrolyte parameters should be measured at regular intervals following initiation of tenofovir therapy...
  8. ncbi Pamidronate-induced tubulointerstitial nephritis with Fanconi syndrome in a patient with primary hyperparathyroidism
    Martin Buysschaert
    Department of Endocrinology and Nutrition, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Bruxelles, Belgium
    Nephrol Dial Transplant 18:826-9. 2003
  9. ncbi Acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab
    Aisha Shaikh
    Wichita Nephrology Group, Wichita, KS, USA
    Ann Pharmacother 43:1370-3. 2009
    To describe a case of acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab.
  10. ncbi Fanconi syndrome and nephrogenic diabetes insipidus associated with didanosine therapy in HIV infection: a case report and literature review
    Géraldine D'Ythurbide
    Department of Nephrology, Kremlin Bicetre Hospital, AP HP, Le Kremlin Bicetre, France
    Nephrol Dial Transplant 22:3656-9. 2007
  11. pmc Idiopathic Fanconi syndrome with progressive renal failure: a case report and discussion
    W S Long
    Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 63:15-28. 1990
    b>Fanconi syndrome is a complex of renal tubular dysfunctions defined by glycosuria without diabetes, aminoaciduria, phosphaturia, and renal tubular acidosis...
  12. ncbi Toward understanding renal Fanconi syndrome: step by step advances through experimental models
    Christophe Sirac
    Laboratoire d Immunologie, CNRS UMR6101, Universite de Limoges, Limoges, France
    Contrib Nephrol 169:247-61. 2011
    Renal Fanconi syndrome (FS) is a generalized dysfunction of proximal tubular epithelial cells leading to the urinary leak of essential metabolites like phosphate, uric acid, glucose, amino acids and low molecular weight proteins...
  13. ncbi L-Histidinol attenuates Fanconi syndrome induced by ifosfamide in rats
    O A Badary
    Department of Pharmacology, College of Pharmacy, Al Azhar University, Cairo, Egypt
    Exp Nephrol 7:323-7. 1999
    ..The aim of this study was to assess whether oral supplementation of LHL could attenuate Fanconi syndrome (FS) induced by IFO...
  14. ncbi Tubulointerstitial nephritis and Fanconi syndrome in primary biliary cirrhosis
    Marie Lino
    Service d Hépatologie AP HP, Hopital Necker, Paris, France
    Am J Kidney Dis 46:e41-6. 2005
    ..Tubulointerstitial nephritis and Fanconi syndrome have been reported more rarely...
  15. ncbi Fanconi syndrome caused by valproic acid
    Ayumi Endo
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Pediatr Neurol 42:287-90. 2010
    ..girl, had been treated with valproic acid from the ages of 5 and 6 months, respectively, and developed Fanconi syndrome. Both patients were bedridden and fed by means of a nasogastric or gastrostomy tube...
  16. ncbi Inhibition of Na(+)-dependent transporters in cystine-loaded human renal cells: electrophysiological studies on the Fanconi syndrome of cystinosis
    Ibrahim Cetinkaya
    Department of Pediatrics, University Children s Hospital Muenster, Muenster, Germany
    J Am Soc Nephrol 13:2085-93. 2002
    Cystinosis is the most common cause of the renal Fanconi syndrome in children, leading to severe electrolyte disturbances and growth failure. A defective lysosomal transporter, cystinosin, results in intralysosomal accumulation of cystine...
  17. ncbi Glomerular protein sieving and implications for renal failure in Fanconi syndrome
    A G Norden
    Department of Clinical Biochemistry, Box 232, Addenbrooke s Hospital, Hill s Road, Cambridge CB2 2QR, England, UK
    Kidney Int 60:1885-92. 2001
    ..We have studied the proteinuria of Fanconi syndrome, a "knock-out" of renal tubular protein reabsorption, to estimate GSCs and detect potential contributors to ..
  18. ncbi Fanconi syndrome caused by antiepileptic therapy with valproic Acid
    Martin Knorr
    Department of General Pediatrics, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Epilepsia 45:868-71. 2004
    ..Regular screening for renal side effects is uncommon. Fanconi syndrome, a generalized dysfunction of renal proximal tubular cells, occurs with some inborn errors of metabolism...
  19. ncbi MYO5B mutations in patients with microvillus inclusion disease presenting with transient renal Fanconi syndrome
    Magdalena R Golachowska
    Department of Cell Biology, Section of Membrane Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Pediatr Gastroenterol Nutr 54:491-8. 2012
    ..We report 2 patients with MVID that developed renal Fanconi syndrome while receiving total parenteral nutrition...
  20. ncbi Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment--case report and review of literature
    Amyn Malik
    Department of Internal Medicine, University of Minnesota, 516 Delaware Street, MMC 194, PWB 14 110, Minneapolis, MN 55108, USA
    J Infect 51:E61-5. 2005
    ..We report another patient who developed Fanconi syndrome while on tenofovir. Her condition improved on discontinuation of the drug...
  21. ncbi Drug-induced Fanconi's syndrome
    Hassane Izzedine
    Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
    Am J Kidney Dis 41:292-309. 2003
    ..Acquired renal tubular defects resulting in FS also have been described in association with many exogenous agents, whether administered or accidentally ingested. This review concentrates on drug-induced FS...
  22. ncbi Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS Patient Care STDS 22:99-103. 2008
    ..A relatively uncommon adverse effect of this drug is Fanconi syndrome. What is known about this toxicity, especially in regards to concomitant medication use and outcomes, is ..
  23. ncbi Fanconi syndrome and renal failure induced by tenofovir: a first case report
    David Verhelst
    Department of Nephrology, Hopital Tenon AP HP, Paris, France
    Am J Kidney Dis 40:1331-3. 2002
    ..The authors report the case of a patient who had Fanconi syndrome, nephrogenic diabetes insipidus, and acute renal failure during treatment with tenofovir, a nucleotide ..
  24. ncbi Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome
    Anthony G W Norden
    Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 13:125-33. 2002
    ..are present in the urine of patients with Dent's disease, Lowe's syndrome, or autosomal dominant idiopathic Fanconi syndrome was explored. They are all forms of the renal Fanconi syndrome and are associated with tubular proteinuria...
  25. ncbi Nephropathic cystinosis: late complications of a multisystemic disease
    Galina Nesterova
    Section on Human Biochemical Genetics, Human Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1851, USA
    Pediatr Nephrol 23:863-78. 2008
    ..prominent feature of cystinosis and, along with dehydration and electrolyte imbalance due to renal tubular Fanconi syndrome, has accounted for the bulk of deaths from this disorder...
  26. ncbi Resveratrol improves ifosfamide-induced Fanconi syndrome in rats
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Toxicol Appl Pharmacol 222:33-41. 2007
    ..The results demonstrated that IFO induced a Fanconi syndrome characterized by increased urinary sodium, phosphate, glucose and protein, along with increased serum ..
  27. ncbi L-Carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Nephrol 24:490-8. 2011
    The effects of L-carnitine on ifosfamide (IFO)-induced Fanconi syndrome have not been studied to date...
  28. ncbi Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome
    Annalisa Vilasi
    Second University of Naples, Italy
    Am J Physiol Renal Physiol 293:F456-67. 2007
    The renal Fanconi syndrome is a defect of proximal tubular function causing aminoaciduria and low-molecular-weight proteinuria...
  29. ncbi Fanconi syndrome associated with didanosine therapy
    Hassane Izzedine
    AIDS 19:844-5. 2005
  30. ncbi Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy
    Mark Nelson
    Imperial College, Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
    AIDS 22:1374-6. 2008
    We report a case of the nucleoside reverse transcriptase inhibitors, stavudine and lamivudine inducing Fanconi syndrome in a patient...
  31. pmc Oral carnitine therapy in children with cystinosis and renal Fanconi syndrome
    W A Gahl
    Section of Human Biochemical Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    J Clin Invest 81:549-60. 1988
    ..with either cystinosis or Lowe's syndrome had a reduced content of plasma and muscle carnitine due to renal Fanconi syndrome. After treatment with oral L-carnitine, 100 mg/kg per d divided every 6 h, plasma carnitine concentrations ..
  32. ncbi Efforts to establish an animal model of Fanconi syndrome after ifosfamide administration to rats
    D Appenroth
    Institute of Pharmacology and Toxicology, Friedrich Schiller University of Jena, Jena, Germany
    J Appl Toxicol 27:327-36. 2007
    About 10% of children develop Fanconi syndrome (FS) a few months after ifosfamide (IFO) treatment...
  33. ncbi Pearson's syndrome presenting with Fanconi syndrome
    R D Gilbert
    Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital, Rondebosch, South Africa
    Ultrastruct Pathol 20:473-5. 1996
    ..The dominant clinical feature was a generalized disorder of proximal tubule function with severe renal magnesium wasting. Renal and muscle biopsies were performed and showed bizarre giant mitochondria...
  34. ncbi A patient with cystinosis presenting transient features of Bartter syndrome
    Bilal Yildiz
    Department of Pediatrics, Osmangazi University Faculty of Medicine, Eskisehir, Turkey
    Turk J Pediatr 48:260-2. 2006
    ..Renal Fanconi syndrome with metabolic acidosis is prominent in cystinosis; however, in rare instances, if sodium-dependent trans-..
  35. ncbi Fanconi syndrome in a patient with β-thalassemia major after using deferasirox for 27 months
    Hsin Yi Wei
    Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Transfusion 51:949-54. 2011
    ..Its advantages are that it is convenient and better tolerated and adhered to due to "once-daily" oral dosage. However, its use in the field is limited and it is yet to be subjected to postmarketing surveillance...
  36. ncbi Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine
    Florence Rollot
    Internal Medicine, Cochin and Saint Vincent de Paul Hospital, Paris, France
    Clin Infect Dis 37:e174-6. 2003
    ..Until there is a better understanding of these interactions, close monitoring is recommended for patients receiving tenofovir, PIs, and didanosine...
  37. ncbi Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome
    Nancy M Brim
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    AIDS Read 17:322-8, C3. 2007
    We report the case of an HIV-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fractures...
  38. ncbi Hypokalemia due to Fanconi syndrome in a patient with obstructive jaundice
    George Liamis
    Department of Internal Medicine, University of Ioannina, Greece
    Nephron 92:711-2. 2002
    ....
  39. ncbi Fanconi's syndrome in HIV+ adults: report of three cases and literature review
    Karen E Earle
    Endocrinology Division, Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Bone Miner Res 19:714-21. 2004
    ..This was temporally related to their HIV treatment. Physicians caring for patients with HIV should recognize the association of this rare syndrome with antiretroviral medications and monitor their patients carefully...
  40. ncbi Detection and analysis of urinary peptides by on-line liquid chromatography and mass spectrometry: application to patients with renal Fanconi syndrome
    Pedro R Cutillas
    BioAnalytical Chemistry Laboratory, Ludwig Institute for Cancer Research, First Floor, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Clin Sci (Lond) 104:483-90. 2003
    ..This approach is a potentially powerful tool to discover new markers and/or causative factors in renal disease; in addition, its sensitivity may also make it applicable to the direct ultramicroanalysis of renal tubule fluid...
  41. ncbi Editorial comment: Fanconi syndrome and tenofovir--understanding proximal tubular function
    Derek M Fine
    AIDS Read 17:326-7. 2007
  42. ncbi Nephropathic cystinosis in adults: natural history and effects of oral cysteamine therapy
    William A Gahl
    National Human Genome Research Institute and Intramural Office of Rare Diseases, National Institutes of Health, Bethesda, Maryland 20892 1851, USA
    Ann Intern Med 147:242-50. 2007
    ..The full burden of nephropathic cystinosis in adulthood and the effects of long-term oral cysteamine therapy on its nonrenal complications have not been elucidated...
  43. ncbi Development of Fanconi syndrome during infancy in a patient with cystinosis
    Elena Levtchenko
    Acta Paediatr 95:379-80. 2006
  44. ncbi Abacavir-induced reversible Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome
    M Ahmad
    Department of Nephrology, University Health Network, University of Toronto, Ontario, Canada
    J Postgrad Med 52:296-7. 2006
    There are several reports of Fanconi syndrome (FS) with or without nephrogenic diabetes insipidus (NDI) in patients with human immunodeficiency virus (HIV) infection, treated with various antiretroviral medications like cidofovir, ..
  45. ncbi The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy
    M J Parsonage
    Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Crumpsall, Manchester, UK
    HIV Med 6:341-6. 2005
    ..developed in patients on tenofovir-containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia. Bone pain was the presenting feature and myopathy followed in one case...
  46. ncbi The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells
    Pedro R Cutillas
    Ludwig Institute for Cancer Research, London, UK
    Am J Physiol Renal Physiol 287:F353-64. 2004
    ..completely reabsorbed in the first segment of the proximal tubule by receptor-mediated endocytosis; in renal Fanconi syndrome (FS), there is failure to reabsorb many of these polypeptides...
  47. ncbi Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases
    Joan M Irizarry-Alvarado
    Division of General Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA
    AIDS Read 19:114-21. 2009
    We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine...
  48. ncbi Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22
    M A Pook
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, London, UK
    Hum Mol Genet 2:2129-34. 1993
    ..22, and a further characterisation of this gene will help to elucidate the factors controlling proximal renal tubular function and the development of kidney stones...
  49. ncbi Exfoliated human proximal tubular cells: a model of cystinosis and Fanconi syndrome
    Guido F Laube
    Nephrourology Unit, Institute of Child Health and University College London Medical School, 30 Guilford Street, London, WC1 N 1EH, UK
    Pediatr Nephrol 20:136-40. 2005
    The renal Fanconi syndrome (FS) is characterised by generalised proximal tubular dysfunction...
  50. ncbi Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
    M Pontoglio
    Unite des Virus Oncogenes, Departement des Biotechnologies, InstitutPasteur, Paris, France
    Cell 84:575-85. 1996
    ..Mutant mice also suffer from severe Fanconi syndrome caused by renal proximal tubular dysfunction...
  51. ncbi Kearns-Sayre syndrome associated with de Toni-Debré-Fanconi syndrome due to cytochrome-c-oxidase (COX) deficiency
    A Berio
    Pediatric Chair, Department of Pediatrics, University of Genoa, Genoa, Italy
    Panminerva Med 43:211-4. 2001
    ..renal tubule: first hyperphosphaturia and hyperaminoaciduria and, later, also glucosuria (de Toni-Debré-Fanconi syndrome), a syndrome to date rarely diagnosed in association with complete Kearns-Sayre syndrome...
  52. ncbi Fanconi syndrome and acute renal failure in a patient treated with tenofovir: a call for caution
    Gabriel Gaspar
    AIDS 18:351-2. 2004
  53. ncbi Patient with Fanconi Syndrome (FS) and retinitis pigmentosa (RP) caused by a deletion and duplication of mitochondrial DNA (mtDNA)
    E M Pitchon
    Jules Gonin Eye Hospital, Lausanne, Switzerland
    Klin Monbl Augenheilkd 224:340-3. 2007
    ..We report a patient with a highly unusual presentation of a mitochondrial disorder...
  54. ncbi Aminoglycoside-associated Fanconi syndrome
    Razvan A Ghiculescu
    Department of Clinical Pharmacology, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Brisbane, Australia
    Am J Kidney Dis 48:e89-93. 2006
    The objective is to describe a case of probable aminoglycoside-induced Fanconi syndrome and make clinicians aware of the existence of this underrecognized and underdiagnosed complication in patients treated with a prolonged course of high-..
  55. ncbi Fanconi's syndrome, interstitial fibrosis and renal failure by aristolochic acid in Chinese herbs
    Yin Tai Hong
    Division of Immunology and Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan
    Pediatr Nephrol 21:577-9. 2006
    ..AAN was diagnosed after other etiologies had been excluded. The case demonstrates the hazards of Chinese herbs with regard to children's health in Taiwan and suggests that more attention should be paid to this issue...
  56. ncbi Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failure
    Brian S Rifkin
    Am J Med 117:282-4. 2004
  57. ncbi [Nephrotoxicity of ifosfamide with special reference to Fanconi Syndrome]
    Elzbieta Rogowska
    Klinika Chirurgii Onkologicznej Dzieci, Instytut Matki i Dziecka, Kasprzaka 17a, 01 211 Warszawa, Poland
    Med Wieku Rozwoj 8:289-95. 2004
    The article is a case presentation of Fanconi syndrome in a patient treated with high doses of ifosfamide. ifosfamide nephrotoxicity relates to glomerular and tubular disfunction...
  58. ncbi Secondary renal Fanconi syndrome caused by valproate therapy
    Toru Watanabe
    Department of Pediatrics, Niigata City General Hospital, Japan
    Pediatr Nephrol 20:814-7. 2005
    Although renal Fanconi syndrome resulting from valproate (VPA) has occasionally been reported, the detailed clinical characteristics of this disease remain unclear...
  59. ncbi Osteomalacia revealing celiac disease and primary biliary cirrhosis-related Fanconi syndrome in a patient with systemic sclerosis
    B Terrier
    Department of Internal Medicine and French Reference Center for necrotizing vasculitides and systemic sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, France
    Clin Exp Rheumatol 26:467-70. 2008
    ..exceptional conditions in the setting of SSc: celiac disease (CD) and primary biliary cirrhosis (PBC)-related Fanconi syndrome. Oral prednisone with angiotensin-converting enzyme inhibitors, was initiated because of active lesions of ..
  60. ncbi Fanconi syndrome and CKD in a patient with paroxysmal nocturnal hemoglobinuria and hemosiderosis
    Po Jen Hsiao
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Neihu 114, Taipei, Taiwan
    Am J Kidney Dis 55:e1-5. 2010
    b>Fanconi syndrome and chronic kidney disease associated with paroxysmal nocturnal hemoglobinuria is rarely reported...
  61. ncbi Fanconi syndrome caused by sodium valproate: report of three severely disabled children
    Hideto Yoshikawa
    Department of Pediatrics, Niigata City General Hospital, Niigata, Japan
    Eur J Paediatr Neurol 6:165-7. 2002
    ..treated with sodium valproate from the age of 2 months, 3 months and 7 years, respectively, and who developed Fanconi syndrome. All three patients were bed-ridden and fed by means of a nasogastric or gastrostomy tube...
  62. ncbi Analysis of molecular forms of urine Retinol-Binding Protein in Fanconi Syndrome and design of an accurate immunoassay
    Keith A Burling
    Core Biochemical Assay Laboratory, NIHR Cambridge Biomedical Research Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    Clin Chim Acta 413:483-9. 2012
    ..Protein in urine (uRBP), a biomarker for the proximal renal tubular disease of congenital and acquired Fanconi Syndrome (FS) occurs in multiple forms...
  63. ncbi Reversible Fanconi syndrome in a pediatric patient on deferasirox
    Michelle N Rheault
    Department of Pediatrics, University of Minnesota Amplatz Children s Hospital, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 56:674-6. 2011
    ..We report one pediatric patient with reversible Fanconi syndrome associated with long-term deferasirox therapy and one patient with mild proximal tubular dysfunction...
  64. ncbi Hypokalemic paralysis as primary presentation of Fanconi syndrome associated with Sjögren syndrome
    Chih Chiang Wang
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces, General Hospital, Kaohsiung, Taiwan, Republic of China
    J Clin Rheumatol 16:178-80. 2010
    Hypokalemic paralysis is a rare presentation of Fanconi syndrome (FS) caused by Sjögren Syndrome (SS). We describe a 39-year-old man who manifested flaccid paralysis of 4 limbs. Laboratory investigations showed profound hypokalemia (1...
  65. ncbi Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient
    Lionel Duck
    Medical Oncology Unit, Centre du Cancer, Cliniques Universitaires St Luc, Av Hippocrate 10, 1200 Brussels, Belgium
    Gynecol Oncol 98:329-31. 2005
    Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia.
  66. ncbi Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report and review of the literature
    David Quimby
    Department of Medicine, University of Illinois at Chicago College of Medicine, USA
    AIDS Read 15:357-64. 2005
    We report a case of Fanconi syndrome associated with the use of tenofovir disoproxil fumarate, a nucleotide reverse transcriptase inhibitor used in the treatment of HIV infection...
  67. ncbi Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus
    Alexandre Karras
    Service de Nephrologie, Hopital Saint Louis, 75475 Paris Cedex 10, France
    Clin Infect Dis 36:1070-3. 2003
    ..Patients receiving tenofovir must be monitored closely for early signs of tubulopathy (glycosuria, acidosis, mild increase in the plasma creatinine level, and proteinuria)...
  68. ncbi Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma
    Cynthia X Ma
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 104:40-2. 2004
    Adult-acquired Fanconi syndrome (FS) is a rare complication of monoclonal gammopathy. We retrospectively reviewed 32 patients diagnosed with adult-acquired FS between April 1968 and June 2002 at Mayo Clinic (Rochester, MN)...
  69. ncbi Selected rare, noninfectious syndromes associated with HIV infection
    Molly E Eaton
    Emory University School of Medicine, Atlanta, GA, USA
    Top HIV Med 13:75-8. 2005
    ..and sometimes treatable noninfectious syndromes associated with HIV disease include tenofovir-associated Fanconi syndrome, a proximal renal tubular disorder; pulmonary hypertension that appears to be due to HIV-driven inflammation ..
  70. ncbi [Acute renal failure and proximal renal tubular dysfuntion in a patient with acquired immunodeficiency syndrome treated with tenofovir]
    F J de la Prada
    Servicio de Nefrologia, Hospital Universitario Son Dureta, Andrea Doria, Palma de Mallorca
    Nefrologia 26:626-30. 2006
    ..renal transport of organic anions leading to proximal tubular intracellular accumulation of tenofovir, yield Fanconi syndrome-type tubulopathy...
  71. ncbi Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice
    Sara Louise Day
    Brighton and Sussex University Hospitals, National Health Service Trust, Brighton, Sussex, United Kingdom
    J Acquir Immune Defic Syndr 38:301-4. 2005
    ..The etiology of HP seems to be multifactorial and unrelated to TDF or renal dysfunction. This questions the utility of routine phosphate testing, in isolation, in TDF recipients...
  72. ncbi [Acute renal failure, Fanconi syndrome and insipidus diabetes in a HIV-infected patient treated with Tenofovir]
    H Harmouche
    Rev Med Interne 26:522-3. 2005
  73. ncbi Editorial comment: tenofovir nephrotoxicity--vigilance required
    Derek M Fine
    AIDS Read 15:362-3. 2005
  74. ncbi Tenofovir-induced renal tubular dysfunction presenting with hypocalcaemia
    John Williams
    Department of Infection and Travel Medicine, The James Cook University Hospital, Marton Rd, Middlesbrough TS4 3BW, UK
    J Infect 52:e107-8. 2006
  75. ncbi Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate
    David H Shepp
    Gilead Sciences, Foster City, California, USA
    AIDS 21:1479-81. 2007
    ..In none of the six fatal cases did hypokalemia appear to contribute to death...
  76. ncbi Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy
    Hassane Izzedine
    Department of Nephrology, La Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie Paris IV, 75013 Paris, France
    J Infect Dis 194:1481-91. 2006
    ..Tenofovir disoproxil fumarate (TDF) may induce renal proximal tubulopathy (rPT). There are no data on pharmacogenomic predictors of rPT in the genes encoding the multidrug-resistance protein (MRP) 2 and MRP4 transporters...
  77. ncbi Toward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity
    Todd Hulgan
    J Infect Dis 194:1471-4. 2006
  78. ncbi Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir
    Sabiha Hussain
    Pediatric Infectious Diseases and Immunology, University of Florida, Jacksonville, FL, USA
    Pediatr Nephrol 21:1034-6. 2006
    Tenofovir-related tubule damage characterized by Fanconi syndrome, renal insufficiency and nephrogenic diabetes insipidus has been reported in the adult HIV-infected population...
  79. ncbi [Proximal tubular impairment (Fanconi syndrome)]
    G Deschenes
    Assistance Publique Hopitaux de Paris, Paris, France
    Arch Pediatr 13:524-5. 2006
  80. ncbi [Role of bone gammagraphy in the diagnosis of secondary osteomalacia in a patient treated with tenofovir]
    M V Torres Isidro
    Servicio de Medicina Nuclear, Hospital Carlos III, Madrid
    Rev Esp Med Nucl 25:103-6. 2006
    ..In further analysis, a secondary hyperparathyroidism and osteomalacia were diagnosed in the context of Fanconi syndrome, an infrequent complication described in patients under treatment with tenofovir.
  81. ncbi Adult onset Fanconi syndrome: extensive tubulo-interstitial lesions and glomerulopathy in the early stage of Chinese herbs nephropathy
    Itsuro Kazama
    Division of Molecular Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Clin Exp Nephrol 8:283-7. 2004
    ..generalized aminoaciduria and glycosuria, features which were consistent with the clinical manifestations of Fanconi syndrome. Renal biopsy was performed when her plasma creatinine was 0...
  82. ncbi The Fanconi syndrome of cystinosis: insights into the pathophysiology
    Abdullah Sakarcan
    Department of Pediatrics, University of South Carolina School of Medicine, South Carolina, USA
    Turk J Pediatr 44:279-82. 2002
    Cystinosis is a lysosomal storage disease, and is one of the most common causes of the Fanconi syndrome. In vitro studies of the cystine-loaded tubule provided insights into the pathophysiology of the proximal tubular defect...
  83. ncbi [From gene to disease: cystinosis]
    E N Levtchenko
    afd Kindergeneeskunde, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 148:476-8. 2004
    ..The most severe infantile form of cystinosis starts with Fanconi syndrome at the age of 3-6 months. Untreated patients develop renal failure before the age of 10...
  84. ncbi Estimating renal function in patients on tenofovir disoproxil fumarate: suggestions for safer use
    J Winston
    HIV Med 7:484-5. 2006
  85. pmc Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California 95616, USA
    Antimicrob Agents Chemother 48:1469-87. 2004
    ....
  86. ncbi Fanconi-like syndrome and rhabdomyolysis in a person with HIV infection on highly active antiretroviral treatment including tenofovir
    Steven Callens
    J Infect 47:262-3. 2003
  87. pmc Late-onset nephropathic cystinosis: clinical presentation, outcome, and genotyping
    Aude Servais
    Department of Nephrology, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Clin J Am Soc Nephrol 3:27-35. 2008
    ....
  88. ncbi Renal lesions in HIV-1-positive patient treated with tenofovir
    Caroline Creput
    AIDS 17:935-7. 2003
  89. ncbi Tenofovir-related nephrotoxicity: case report and review of the literature
    Christopher W James
    HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899 1668, USA
    Pharmacotherapy 24:415-8. 2004
    ..However, our case report and literature review underscore the importance of monitoring renal function when treating patients with any nucleotide reverse transcriptase inhibitor...
  90. ncbi Perioperative care of the patient with nephropathic cystinosis
    Theresa L Ray
    Department of Child Health, The Division of Pediatric Critical Care Pediatric Anesthesiology, The University of Missouri, Columbia, MO, USA
    Paediatr Anaesth 14:878-85. 2004
    ..Issues of primary concern during perioperative care include preservation of renal function and maintenance of fluid and electrolyte homeostasis...
  91. ncbi Acquired fanconi syndrome with osteomalacia secondary to monoclonal gammopathy of undetermined significance
    Toru Hashimoto
    Division of Hypertension and Nephrology, National Kyushu Medical Center, Fukuoka, Japan
    Intern Med 46:241-5. 2007
    ..Examination revealed hypophosphatemic osteomalacia and acquired Fanconi syndrome. Further exploration revealed monoclonal gammopathy of undetermined significance (MGUS) excreting urinary ..
  92. ncbi Expanding the pathologic spectrum of immunoglobulin light chain proximal tubulopathy
    Umesh Kapur
    Department of Pathology, Loyola University Medical Center, Maywood, Ill, USA
    Arch Pathol Lab Med 131:1368-72. 2007
    ..In plasma cell dyscrasias, involvement of the distal tubules is frequent and well characterized. In contrast, proximal tubules have only rarely been reported to show diagnostic pathology such as intracytoplasmic crystals...
  93. ncbi Tubular changes in early diabetic nephropathy
    M C Thomas
    Danielle Alberti Memorial Centre for Diabetes Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Adv Chronic Kidney Dis 12:177-86. 2005
    ..From this "holonephric" point of view, an understanding of the changes in the diabetic tubule forms an important component to the understanding of kidney disease in diabetes...
  94. ncbi Paraquat-induced Fanconi syndrome
    Hyo W Gil
    Department of Internal Medicine and Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea
    Nephrology (Carlton) 10:430-2. 2005
    ..Although paraquat has been established as one cause of acute tubular necrosis, Fanconi syndrome presenting as severe hypophosphataemia after paraquat intoxication has not been reported...
  95. ncbi Fanconi's syndrome induced by a monoclonal Vkappa3 light chain in Waldenstrom's macroglobulinemia
    Frank Bridoux
    Department of Nephrology, University Hospital, Poitiers, France
    Am J Kidney Dis 45:749-57. 2005
    ..Mechanisms other than resistance of LCs to endosomal proteolysis probably are involved in the pathogenesis of FS-associated plasma cell dyscrasias...
  96. ncbi Metabolomic study of cisplatin-induced nephrotoxicity
    D Portilla
    Department of Internal Medicine, Division of Nephrology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Kidney Int 69:2194-204. 2006
    ..We propose that the injury-induced metabolic profile may be used as a biomarker of cisplatin-induced nephrotoxicity...
  97. ncbi A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II
    Jonas Heilskov Graversen
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark
    Lipids 43:467-70. 2008
    Renal handling of major HDL components was studied by analyzing urine from patients with Fanconi syndrome, a rare renal proximal tubular reabsorption failure, including dysfunction of the kidney HDL receptor, cubilin...
  98. ncbi Prominent hypophosphatemia due to proximal tubulopathy mimicking Fanconi's syndrome in a patient with obstructive jaundice
    G Kalambokis
    Clin Nephrol 65:306-7. 2006
  99. ncbi [Chinese herbs-induced renal failure with Fanconi syndrome: a report of 6 cases]
    Yang Yu
    Renal Division, Deptartment of Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China
    Zhonghua Nei Ke Za Zhi 42:110-2. 2003
    To understand the clinical and pathological features of patients with Fanconi syndrome associated with renal function damage induced by Chinese herbs.
  100. ncbi Skeletal scintigraphy in acquired adult Fanconi syndrome
    Vincent M Brandenburg
    Medical Clinic II, Division of Nephrology, University Hospital, Medical School, Aachen, Germany
    Clin Nucl Med 27:53-4. 2002
  101. ncbi Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome
    Yi Sun Yang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, 110 Sec 1, Chien Kuo N Road, Taichung, 402, Taiwan
    Rheumatol Int 27:593-7. 2007
    ..Conversely, in patients with Sjögren's syndrome, early investigation and treatment of renal tubular dysfunction may prevent future complications, such as osteomalacia...

Research Grants28

  1. Lentiviral-transduced hematopoictic stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..Affected individuals typically present with proximal tubulopathy (Fanconi syndrome) before one year of age and without specific treatment progress to end-stage renal failure by the end of the ..
  2. Secretory Vesicle Function During Spermatogenesis & Fertilization in C. elegans
    STEVEN W L apos HERNAULT; Fiscal Year: 2010
    ..In addition to its role during spermatogenesis, V-ATPase function is defective in diseases that include renal Fanconi syndrome and the bone diseases, infantile ostepetrosis and osteoporosis...
  3. Kidney-targeted gene delivery for cystinosis
    Stephanie Cherqui; Fiscal Year: 2012
    ..Affected individuals typically present with proximal tubulopathy (Fanconi syndrome) before one year of age and without specific treatment progress to end-stage renal failure by the end of the ..
  4. OCRL and the pathogenesis of Lowe Syndrome and Dent Disease
    Pietro De Camilli; Fiscal Year: 2013
    ..is a severe X-linked disorder characterized by reabsorption defects in the kidney proximal tubule (renal Fanconi syndrome), mental retardation and congenital cataracts...
  5. MECHANISMS OF INHERITED MEMBRANE TRANSPORT DISORDERS
    Stanton Segal; Fiscal Year: 1992
    ..of amino acids and sugar with emphasis on cystinuria as the prototypic inherited transport abnormality, the Fanconi syndrome associated with several inherited metabolic diseases with its global disarray of solute transport systems and ..
  6. EXPERIMENTAL CYSTINE STORAGE MODEL OF FANCONI SYNDROME
    John Foreman; Fiscal Year: 1990
    The Fanconi syndrome, a global renal tubule disorder, is an enigmatic problem which most commonly is associated with cystinosis in pediatrics...
  7. Cd2+, Metallothionein and Transcriptional Control of Na+ Glucose Co-Transporter 1
    DAVID PETERING; Fiscal Year: 2009
    Chronic exposure to Cd2+ in humans causes kidney failure that is characterized as a Fanconi syndrome, in which an array of Na+-dependent nutrient transport processes is inhibited...
  8. MOLECULAR REGULATION OF 1,25(OH)2D PRODUCTION
    Anthony Portale; Fiscal Year: 2002
    ..failure, X-linked hypophosphatemic rickets, autosomal recessive vitamin D dependent rickets Type 1, renal Fanconi syndrome, and with advanced age...
  9. ROLE OF PROTEIN KINASES IN TRANSPORT REGULATION
    Mary Taub; Fiscal Year: 2004
    ..The possible involvement of an inhibitory phosphatase, in regulating the phosphorylation of the Na,K-ATPase will also be examined. ..
  10. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  11. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  12. Topical virucides to prevent oral transmission
    Koen van Rompay; Fiscal Year: 2004
    ..If topical tenofovir administration were effective, then this simple strategy would be highly affordable for developing countries. ..
  13. Brain Structure and Cognition in Cystinosis
    Doris Trauner; Fiscal Year: 2007
    ..The study results may also provide a basis for developing early interventions for children "at risk" for cognitive deficits because of the presence of a genetic disorder. ..
  14. Language Development Following Early Focal Brain Injury
    Doris Trauner; Fiscal Year: 2008
    ..Knowledge gained in this study may form the basis for more effective interventions to help improve neurodevelopmental outcome of children with brain damage in the future. [unreadable] [unreadable]..
  15. Contemporary Diagnosis and Treatment of Vitamin D-Related Disorders
    Marc Drezner; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. Modulation of Electrogenic Sodium Bicarbonate Transport
    Ira Kurtz; Fiscal Year: 2007
    ..Successful completion of this project will enhance our understanding of the mechanisms responsible for regulating H+/base transporters. ..
  17. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..
  18. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  19. Neuro-cognitive Outcome After Early Focal Brain Damage
    Doris Trauner; Fiscal Year: 2007
    ..The findings may further serve as a basis from which to design more effective interventions for children at risk for cognitive dysfunction because of early brain damage. ..
  20. Membrane Transport of NH3 and NH4+
    NAZIH NAKHOUL; Fiscal Year: 2008
    ..These are new properties of NH3/NH4+ transport that will help explain the role of NH3 and NH4+ in acidosis and their effect on transport of other ions a well. ..
  21. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
    ..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
  22. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  23. Isolation of Murine Pancreatic Liver Stem Cells
    Markus Grompe; Fiscal Year: 2004
    ..Monoclonal antibodies useful for FACS sorting of pancreatic cells will be generated. We will apply cell-sorting methods to enrich pancreatic liver stem cells. ..
  24. FASEB Conference: Mechanisms of Liver Growth and Disease
    Markus Grompe; Fiscal Year: 2004
    ..abstract_text> ..
  25. Cell Therapy by In Vivo Fusion
    Markus Grompe; Fiscal Year: 2007
    ..Aim 3 is geared toward enhancing the efficiency of in vivo fusion and thereby increasing the number of bone marrow derived hepatocytes. Fusogenic viral envelope proteins will be used to artificially induce cell fusion. ..