kidney diseases

Summary

Top Publications

  1. ncbi Podocyte biology and response to injury
    Peter Mundel
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 13:3005-15. 2002
  2. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
  3. ncbi National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification
    Andrew S Levey
    Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 139:137-47. 2003
  4. ncbi Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
  5. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  6. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
  7. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  8. ncbi Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes
    A S Levey
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 72:247-59. 2007
  9. ncbi Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    Douglas S Keith
    Division of Nephrology and Hypertension, Oregon Health and Science University, USA
    Arch Intern Med 164:659-63. 2004
  10. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003

Research Grants

Detail Information

Publications294 found, 100 shown here

  1. ncbi Podocyte biology and response to injury
    Peter Mundel
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 13:3005-15. 2002
  2. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
    ..End-stage renal disease substantially increases the risks of death, cardiovascular disease, and use of specialized health care, but the effects of less severe kidney dysfunction on these outcomes are less well defined...
  3. ncbi National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification
    Andrew S Levey
    Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 139:137-47. 2003
    ..Because of the high prevalence of early stages of chronic kidney disease in the general population (approximately 11% of adults), this information is particularly important for general internists and specialists...
  4. ncbi Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
    ..73 m(2) for 3 months or more, irrespective of cause. Kidney damage in many kidney diseases can be ascertained by the presence of albuminuria, defined as albumin-to-creatinine ratio >30 mg/g in two ..
  5. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  6. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ....
  7. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  8. ncbi Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes
    A S Levey
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 72:247-59. 2007
    ..KDIGO will work in collaboration with international and national public health organizations to facilitate implementation of these recommendations...
  9. ncbi Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    Douglas S Keith
    Division of Nephrology and Hypertension, Oregon Health and Science University, USA
    Arch Intern Med 164:659-63. 2004
    ..The purpose of this study was to understand the natural history of chronic kidney disease with regard to progression to renal replacement therapy (transplant or dialysis) and death in a representative patient population...
  10. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  11. ncbi Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction
    Nagesh S Anavekar
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1285-95. 2004
    ..Renal failure is associated with one of the highest risks, but the influence of milder degrees of renal impairment is less well defined...
  12. ncbi Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, 22908, USA
    Kidney Int 75:1145-52. 2009
    ..The UUO model is likely to reveal useful biomarkers of progression of renal disease, as well as new therapies, which are desperately needed to allow intervention before the establishment of irreversible renal injury...
  13. pmc Macrophage diversity in renal injury and repair
    Sharon D Ricardo
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    J Clin Invest 118:3522-30. 2008
    ..Furthermore, parallels with pathological processes in many other organs also exist...
  14. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  15. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
    ..Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values...
  16. ncbi Cisplatin nephrotoxicity: mechanisms and renoprotective strategies
    N Pabla
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, Georgia 30912, USA
    Kidney Int 73:994-1007. 2008
    ..Examination of tumor-bearing animals and identification of novel renoprotective strategies that do not diminish the anticancer efficacy of cisplatin are essential to the development of clinically applicable interventions...
  17. ncbi Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
    ..We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods...
  18. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Hypertension 42:1050-65. 2003
  19. ncbi Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach
    Alexandre Lautrette
    INSERM U426, Hopital Necker Enfants Malades, IFR 94, Universite Paris 5, 149 rue de Sevres, 75015 Paris, France
    Nat Med 11:867-74. 2005
    ..These findings indicate a crucial role for AngII-dependent EGFR transactivation in renal deterioration and identify in TACE inhibitors a new therapeutic strategy for preventing progression of chronic renal diseases...
  20. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
    ..These data imply that TLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury...
  21. ncbi Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Yui Pong Siu
    Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Am J Kidney Dis 47:51-9. 2006
    ....
  22. ncbi Predictors of new-onset kidney disease in a community-based population
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 291:844-50. 2004
    ..Kidney disease is associated with an increased risk for the development of cardiovascular disease and end-stage renal disease; however, risk factors for kidney disease have not been well studied...
  23. ncbi All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan
    Chi Pang Wen
    Center for Health Policy Research and Development, National Health Research Institutes, Zhunan, Taiwan
    Lancet 371:2173-82. 2008
    ..We assessed prevalence and mortality risks for all stages of chronic kidney disease and quantified its attributable mortality in Taiwan...
  24. ncbi Chronic kidney disease: the global challenge
    A Meguid El Nahas
    Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
    Lancet 365:331-40. 2005
    ..Consideration is given to health economics. A global and concerted approach to CKD must be adopted in both more and less developed countries to avoid a major catastrophe...
  25. ncbi TGF-beta signaling in renal disease
    Erwin P Bottinger
    Unified Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine Bronx, New York 10461, USA
    J Am Soc Nephrol 13:2600-10. 2002
    ..a role for the cytokine TGF-beta as key mediator of glomerular and tubulointerstitial pathobiology in chronic kidney diseases, studies of TGF-beta signaling in the kidney have focused on the molecular biology of fibrogenesis...
  26. ncbi Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco 94121, USA
    JAMA 293:1737-45. 2005
    ..Elderly persons with chronic kidney disease have substantial risk for cardiovascular mortality, but the relative importance of traditional and novel risk factors is unknown...
  27. ncbi Obesity-related glomerulopathy: an emerging epidemic
    N Kambham
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Kidney Int 59:1498-509. 2001
    ..The ten-fold increase in incidence over 15 years suggests a newly emerging epidemic. Heightened physician awareness of this entity is needed to ensure accurate diagnosis and appropriate therapy...
  28. ncbi Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 42:617-22. 2003
  29. ncbi Prevalence of kidney damage in Australian adults: The AusDiab kidney study
    Steven J Chadban
    Department of Nephrology, Monash Medical Centre, USA
    J Am Soc Nephrol 14:S131-8. 2003
    ..Identifying and targeting this section of the population may provide a means to reduce the burden of ESRD...
  30. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    ..With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure...
  31. ncbi Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
    ..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community...
  32. ncbi Relationship of uric acid with progression of kidney disease
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 50:239-47. 2007
    ..Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression...
  33. ncbi Transforming growth factor-beta and Smad signalling in kidney diseases
    Wansheng Wang
    Department of Medicine Nephrology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nephrology (Carlton) 10:48-56. 2005
    ..renal fibrosis in various animal models including rat obstructive kidney, remnant kidney and diabetic kidney diseases. Results from these studies indicate that Smad signalling is a key and final common pathway of renal fibrosis...
  34. ncbi A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
    ..These studies provide direct evidence that uric acid may be a true mediator of renal disease and progression...
  35. ncbi Transcription factor-kappa B (NF-kappa B) and renal disease
    C Guijarro
    , , Madrid, Spain
    Kidney Int 59:415-24. 2001
    ..A better understanding of the mechanisms involved in NF-kappa B regulation and its modulation may provide new tools to improve the treatment of renal diseases with a better sound pathophysiological approach...
  36. pmc Uric acid and incident kidney disease in the community
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    J Am Soc Nephrol 19:1204-11. 2008
    ....
  37. ncbi Inducible rodent models of acquired podocyte diseases
    Jeffrey W Pippin
    Division of Nephrology, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Box 356521, Seattle, WA 98195, USA
    Am J Physiol Renal Physiol 296:F213-29. 2009
    ..Details are given on the model backgrounds, how to induce each model, the interpretations of the data, and the benefits and shortcomings of each. Genetic rodent models of podocyte injury are excluded...
  38. ncbi Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 141:929-37. 2004
    ..However, healthy persons were not included in the development of the MDRD equation...
  39. ncbi Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program
    Gary L Myers
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Clin Chem 52:5-18. 2006
    ..Available resources for standardization of serum creatinine measurement are discussed, and recommendations for measurement improvement are given...
  40. ncbi Vitamin D levels and patient outcome in chronic kidney disease
    Pietro Ravani
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 75:88-95. 2009
    ..Our study shows that plasma 25-hydroxyvitamin D is an independent inverse predictor of disease progression and death in patients with stage 2-5 chronic kidney disease...
  41. pmc Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis
    Gavin Y Oudit
    Rm 68, 150 College St, Heart and Stroke Richard Lewar Centre of Excellence, Fitzgerald Bldg, University of Toronto, Toronto M5S 3E2, Canada
    Am J Pathol 168:1808-20. 2006
    ..These findings have important implications for our understanding of ACE2, the renin-angiotensin system, and gender in renal injury, with ACE2 likely to be an important therapeutic target in kidney disease...
  42. ncbi Kidney function is related to cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 39:55-61. 2008
    ..We investigated this association in a population-based study of elderly persons...
  43. pmc Elevated uric acid increases the risk for kidney disease
    Rudolf P Obermayr
    3rd Medical Department, Donauspital, Sozialmedizinisches Zentrum Ost der Stadt Wien, Langobardenstrasse 122, A 1220 Vienna, Austria EU
    J Am Soc Nephrol 19:2407-13. 2008
    ..In conclusion, elevated levels of uric acid independently increase the risk for new-onset kidney disease...
  44. ncbi Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children
    Anders Grubb
    Department of Clinical Chemistry, Competence Centre for Clinical Research, Department of Nephrology, University Hospital, Lund, Sweden
    Clin Chem 51:1420-31. 2005
    ..73 m(2))(-1). The present study analyzes whether these GFR prediction equations for adults and children might be replaced by simple prediction equations based on plasma concentrations of cystatin C...
  45. ncbi Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease...
  46. ncbi The metabolic syndrome and chronic kidney disease in U.S. adults
    Jing Chen
    Tulane University Schools of Medicine and Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Ann Intern Med 140:167-74. 2004
    ..The metabolic syndrome is a common risk factor for cardiovascular disease...
  47. pmc Systems biology of kidney diseases
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 81:22-39. 2012
    b>Kidney diseases manifest in progressive loss of renal function, which ultimately leads to complete kidney failure. The mechanisms underlying the origins and progression of kidney diseases are not fully understood...
  48. pmc TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29
    Wei Qin
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, NT, Hong Kong, China
    J Am Soc Nephrol 22:1462-74. 2011
    ..In conclusion, miR-29 is a downstream inhibitor of TGF-β/Smad3-mediated fibrosis and may have therapeutic potential for diseases involving fibrosis...
  49. ncbi Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:864-81. 2003
    ..Clinical trials focusing on MICS and its possible causes and consequences are urgently required to improve poor clinical outcome in dialysis patients...
  50. ncbi Wnt signalling in kidney diseases: dual roles in renal injury and repair
    Takahisa Kawakami
    Department of Medicine, and Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    J Pathol 229:221-31. 2013
    ..pathway in nephrogenesis is well established, recent investigations have shown its involvement in many adult kidney diseases, including ischaemic kidney injury, glomerular diseases, diabetic nephropathy, interstitial fibrosis and ..
  51. ncbi Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics
    Leon G Fine
    Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California, USA
    Kidney Int 74:867-72. 2008
    ..The limited success of existing strategies in retarding chronic kidney disease mandates that these new avenues of treatment be explored...
  52. ncbi Smad7 as a therapeutic agent for chronic kidney diseases
    Hui Yao Lan
    Department of Medicine, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong
    Front Biosci 13:4984-92. 2008
    ..that gene transfer of Smad7 is able to inhibit renal fibrosis in a number of experimental models of chronic kidney diseases, including obstructive nephropathy, remnant kidney disease, and autoimmune crescentic glomerulonephritis...
  53. ncbi Aquaporins in the kidney: from molecules to medicine
    Søren Nielsen
    The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
    Physiol Rev 82:205-44. 2002
    ..Continued analysis of the aquaporins is providing detailed molecular insight into the fundamental physiology and pathophysiology of water balance and water balance disorders...
  54. pmc Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    Li Yang
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:535-43, 1p following 143. 2010
    ..Hence, epithelial cell cycle arrest at G2/M and its subsequent downstream signaling are hitherto unrecognized therapeutic targets for the prevention of fibrosis and interruption of the accelerated progression of kidney disease...
  55. ncbi Molecular basis of renal fibrosis
    A A Eddy
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, CH 46, 4800 Sand Point Way, NE, Seattle, WA 98105 0371, USA
    Pediatr Nephrol 15:290-301. 2000
    ..During this time the tubules and peritubular capillaries are obliterated. The number of intact nephrons progressively declines resulting in a continuous reduction in glomerular filtration...
  56. ncbi How does proteinuria cause progressive renal damage?
    Mauro Abbate
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    J Am Soc Nephrol 17:2974-84. 2006
    ..Finally, proximal tubular cell receptors for uptake of plasma proteins that are under investigation may provide activation signals on excess tubular protein handling...
  57. ncbi Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury
    Frank Dieterle
    Novartis Institutes for BioMedical Research, Novartis, Basel, Switzerland
    Nat Biotechnol 28:463-9. 2010
    ..The recognition of the qualification of these biomarkers by the EMEA and FDA will significantly enhance renal safety monitoring...
  58. ncbi Leptin and renal disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Am J Kidney Dis 39:1-11. 2002
    ..These findings collectively suggest that the kidney is not only a site of leptin metabolism, but also a target organ for leptin action in pathophysiological states...
  59. pmc Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    J Yang
    Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1465-75. 2001
    ....
  60. ncbi The spectrum of MYH9-associated nephropathy
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 5:1107-13. 2010
    ..polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) have been associated with nondiabetic kidney diseases in African- and European-derived populations...
  61. ncbi Obstructive nephropathy and renal fibrosis
    Saulo Klahr
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110 1092, USA
    Am J Physiol Renal Physiol 283:F861-75. 2002
    ..Some of the findings of the animal model have been compared with observations made in patients with obstructive nephropathy. Most of the evidence suggests that the rodent model of UUO is reflective of human renal disease processes...
  62. ncbi Glomeruli and blood pressure. Less of one, more the other?
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115
    Am J Hypertens 1:335-47. 1988
    ..This may also account for the susceptibility of subsets of Type I and Type II diabetics to develop overt glomerulopathy...
  63. ncbi Intrinsic epithelial cells repair the kidney after injury
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Cell Stem Cell 2:284-91. 2008
    ..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney...
  64. ncbi The burden of kidney disease: improving global outcomes
    Garabed Eknoyan
    Baylor College of Medicine, Houston, Texas 77030, USA
    Kidney Int 66:1310-4. 2004
    ..Its stated mission is "Improve the care and outcomes of kidney disease patients worldwide through promoting coordination, collaboration and integration of initiatives to develop and implement clinical practice guidelines."..
  65. ncbi Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Kidney Dis 50:918-26. 2007
    ....
  66. ncbi Worsening renal function and prognosis in heart failure: systematic review and meta-analysis
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Card Fail 13:599-608. 2007
    ..The present study was designed to establish the proportion of patients with HF that exhibits (WRF) and the associated risk for mortality and hospitalization by conducting a systematic review and meta-analysis...
  67. pmc Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
    Giuseppe Remuzzi
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    J Clin Invest 116:288-96. 2006
    The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem...
  68. ncbi Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  69. ncbi Polyomavirus BK
    Hans H Hirsch
    Division of Infectious Diseases, Department of Internal Medicine, University Hospitals Basel, and Transplantation Virology Laboratory, Institute of Medical Microbiology, University of Basel, Switzerland
    Lancet Infect Dis 3:611-23. 2003
    ..Case series suggest that cidofovir might be effective, especially when combined with reduced immunosuppression...
  70. ncbi N-acetylcysteine and contrast-induced nephropathy in primary angioplasty
    Giancarlo Marenzi
    Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Institute of Cardiology, University of Milan, Milan, Italy
    N Engl J Med 354:2773-82. 2006
    ..We investigated the antioxidant N-acetylcysteine for the prevention of contrast-medium-induced nephropathy in patients undergoing primary angioplasty...
  71. ncbi Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children--a meta-analysis
    Juliana F Roos
    School of Pharmacy, University of Queensland, Brisbane, QLD 4072, Australia
    Clin Biochem 40:383-91. 2007
    ..To perform a systematic review comparing the diagnostic accuracy of CysC with SCr...
  72. ncbi Metabolomics in the study of kidney diseases
    Robert H Weiss
    Division of Nephrology, Department of Internal Medicine, Genome and Biomedical Sciences Building, Room 6312, University of California, Davis, CA 95616, USA
    Nat Rev Nephrol 8:22-33. 2012
    ..Thus, metabolomics holds promise for early diagnosis, increased choice of therapy and the identification of new metabolic pathways that could potentially be targeted in kidney disease...
  73. ncbi Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients
    Hans H Hirsch
    Division of Infectious Diseases, University of Basel, Basel, Switzerland
    N Engl J Med 347:488-96. 2002
    ....
  74. ncbi Renal function as a predictor of outcome in a broad spectrum of patients with heart failure
    Hans L Hillege
    Medical Center Groningen, University of Groningen, The Netherlands
    Circulation 113:671-8. 2006
    ..The aim of this analysis was to evaluate the prognostic importance of renal function in a broader spectrum of patients with CHF...
  75. ncbi The role of vascular endothelial growth factor (VEGF) in renal pathophysiology
    Bieke F Schrijvers
    Renal Unit, Department of Internal Medicine, Gent University Hospital, Gent, Belgium
    Kidney Int 65:2003-17. 2004
    ..In conclusion, VEGF is required for growth and proliferation of glomerular and peritubular endothelial cells. While deleterious in some, it may contribute to recovery in other forms of renal diseases...
  76. ncbi Signaling danger: toll-like receptors and their potential roles in kidney disease
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Klinikum der Universität München Junenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:854-67. 2004
    ..Here the authors provide an overview on the biology of TLR, summarize the present data on their expression in the kidney, and provide an outlook for the potential roles of TLR in kidney disease...
  77. ncbi Prospective study of renal function in HIV-infected pediatric patients receiving tenofovir-containing HAART regimens
    Pere Soler-Palacín
    Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d Hebron University Hospital, Spain
    AIDS 25:171-6. 2011
    ..to describe the impact of tenofovir disoproxil fumarate (TDF) use on renal function in HIV-infected pediatric patients...
  78. ncbi NGAL is an early predictive biomarker of contrast-induced nephropathy in children
    Russel Hirsch
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 22:2089-95. 2007
    ..52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN...
  79. ncbi Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations
    Hans H Hirsch
    Transplantation Virology, Institute for Medical Microbiology and Div Infectious Diseases, Universitatsspital Basel, Switzerland
    Transplantation 79:1277-86. 2005
    ..25-0.33 mg/kg intravenously biweekly) without probenicid should be considered for refractory cases. Retransplantation after renal allograft loss to PVAN remains a treatment option for patients clearing polyomavirus replication...
  80. ncbi Effect of lipid reduction on the progression of renal disease: a meta-analysis
    L F Fried
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 59:260-9. 2001
    ..We examined the effects of antilipemic agents on glomerular filtration rate and proteinuria or albuminuria in patients with renal disease...
  81. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
    ..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
  82. ncbi A differential diagnostic model of diabetic nephropathy and non-diabetic renal diseases
    Jianhui Zhou
    Department of Nephrology, Institute of Nephrology of Chinese PLA, General Hospital of Chinese PLA, Beijing, People s Republic of China
    Nephrol Dial Transplant 23:1940-5. 2008
    ..The clinical differentiation between these two categories is usually not so clear and effective. This study aims to develop a quantified differential diagnostic model...
  83. ncbi Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy
    Miguel Goicoechea
    Antiviral Research Center, University of California, San Diego, 150 W Washington St, Ste 100, San Diego, CA 92103, USA
    J Infect Dis 197:102-8. 2008
    ....
  84. ncbi Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    Pediatr Res 68:91-8. 2010
    ..Here, we review current knowledge regarding the genetic contributions to renal hypoplasia with particular emphasis on the mechanisms that control nephron endowment in humans and mice...
  85. ncbi Non-diabetic renal disease in patients with non-insulin dependent diabetes mellitus
    E Y Lee
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Korea
    Yonsei Med J 40:321-6. 1999
    ..In summary, when there is a short duration of diabetes mellitus, or an absence of retinopathy seen in patients with NIDDM, then renal biopsy in diabetic patients aids in the detection of NDRD...
  86. ncbi Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    Hui Y Lan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 14:1535-48. 2003
    ..TGF-beta-mediated renal fibrosis is regulated positively by Smad2/3, but negatively by Smad7. Target blockade of TGF-beta/Smad signaling by expression of Smad7 may provide a new therapeutic potential for renal fibrosis...
  87. ncbi Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    ..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
  88. ncbi Renal abnormalities and their developmental origin
    Andreas Schedl
    INSERM, U636, F 06108 Nice, France
    Nat Rev Genet 8:791-802. 2007
    ..Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how the kidney develops...
  89. ncbi Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7
    Wansheng Wang
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Alkek N520, Houston, Texas 77030, USA
    J Am Soc Nephrol 16:1371-83. 2005
    ..Smad7-mediated inhibition of NF-kappaB activation via the induction of IkBalpha may be the central mechanism by which latent TGF-beta prevents renal inflammation...
  90. ncbi Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:2295-304. 2005
    ..This suggests protective mechanisms, or naturally occurring inhibitors, of calcification may be important...
  91. pmc Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions
    Giuliano Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstr 3A, 48149 Munster, Germany
    Am J Pathol 176:1169-80. 2010
    ..These findings are very important to establish chemotherapeutical protocols aimed to maximize the antineoplastic effect of cisplatin while reducing the risk of toxicities...
  92. pmc Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury
    K J Kelly
    Medical and Pathology Services, Massachusetts General Hospital, Boston 02114, USA
    J Clin Invest 97:1056-63. 1996
    ..Thus, ICAM-1 is a key mediator of ischemic acute renal failure likely acting via potentiation of neutrophilendothelial interactions...
  93. ncbi Mechanisms of disease: Fibroblasts--a new look at an old problem
    Eric G Neilson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    Nat Clin Pract Nephrol 2:101-8. 2006
    ..This review examines these issues and identifies new targets for the treatment of one of the most difficult problems facing clinical nephrology...
  94. ncbi Evidence of tubular hypoxia in the early phase in the remnant kidney model
    Krissanapong Manotham
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:1277-88. 2004
    ..The initial hypoxia in this model was dependent on activation of the renin-angiotensin system and hemodynamic alterations after nephron loss...
  95. ncbi Cystatin C: an improved estimator of glomerular filtration rate?
    Omar F Laterza
    Washington University School of Medicine, Department of Pathology and Immunology, Division of Laboratory Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Clin Chem 48:699-707. 2002
    ..The purpose of this review is to critically review the potential utility of cystatin C (CysC), especially in patient populations in which CysC may have an advantage over routinely used endogenous markers of GFR...
  96. ncbi Glomerular filtration rate estimated by cystatin C among different clinical presentations
    A D Rule
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 69:399-405. 2006
    ..Other factors, possibly inflammation or immunosuppression therapy, affect cystatin C levels. While recognizing this limitation, cystatin C may improve GFR estimates in chronic kidney disease patients...
  97. ncbi Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3
    Fuye Yang
    Department of Medicine and Therapeutic, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Hypertension 54:877-84. 2009
    ..In conclusion, Ang II induces tubular CTGF expression and renal fibrosis via the TGF-beta-dependent and -independent Smad3 signaling pathways, suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy...
  98. ncbi Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland
    Melanie K Haroun
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 14:2934-41. 2003
    ....
  99. ncbi Contrast-induced nephropathy
    Tadhg G Gleeson
    Department of Radiology, Mater Misericordiae University Hospital, Eccles St, Dublin 9, Ireland
    AJR Am J Roentgenol 183:1673-89. 2004
  100. ncbi Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study
    R Mañalich
    National Institute of Nephrology, National Referral Center for Pathology, and González Coro Gynecology Obstetric Hospital, Havana, Cuba
    Kidney Int 58:770-3. 2000
    ..Low nephron number may be an independent risk factor for the development of hypertension. We therefore decided to evaluate the relationship between body weight at birth and the number and size of nephron units...
  101. ncbi Sustained, long-term renal stabilization after 54 months of agalsidase beta therapy in patients with Fabry disease
    Dominique P Germain
    Assistance Publique Hopitaux de Paris, Paris, France
    J Am Soc Nephrol 18:1547-57. 2007
    ..Long-term agalsidase beta therapy stabilizes renal function in patients without renal involvement at baseline, maintains reduction of plasma GL-3, and sustains GL-3 clearance in capillary endothelial cells and multiple renal cell types...

Research Grants74

  1. CHEMOKINE THERAPEUTIC TARGETS FOR KIDNEY DISEASE
    VICKI KELLEY; Fiscal Year: 2004
    DESCRIPTION:An influx of leukocytes is common to progressive kidney diseases. Targeting specific molecules responsible for recruitment of leukocytes into the kidney provides a therapeutic strategy for halting tissue progressive damage...
  2. The Role of Dendritic Cells in Renal Immune Responses
    Karl Nath; Fiscal Year: 2007
    ..Infiltration of the renal parenchyma by inflammatory cells, including lymphocytes, is a common feature of kidney diseases even in the apparent absence of exogenous immune stimuli...
  3. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ..sFlt1 and the elucidation of signaling pathways in GEC has broad implication for the study of proteinuric kidney diseases and may provide new therapeutic targets for treatment of hypertension and proteinuria...
  4. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..Background: Chronic kidney diseases (CKD) take one of the highest tolls on human health...
  5. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..non-canonical Wnt signaling, hedgehog signaling, and cell cycle regulation in the pathogenesis of cystic kidney diseases. In addition, we demonstrated that specific mutated alleles determine the disease phenotype of NPHP-related ..
  6. Mechanisms of tubular atrophy in renal disease
    Jeffrey R Schelling; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Over 26 million people in the U.S. have chronic kidney diseases, most commonly from diabetic glomerular injury...
  7. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..to treat patients with severe forms of kidney injury, 3) development of in vitro models of patient-specific kidney diseases, and 4) the development of kidney-specific efficacy and toxicity screens for potential therapeutics...
  8. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..to test the feasibility of microRNA-based therapeutics as a novel strategy for the treatment of rare cystic kidney diseases. Autosomal recessive cystic kidney diseases include autosomal recessive polycystic kidney disease (ARPKD), ..
  9. FASEB SRC on
    Bradley K Yoder; Fiscal Year: 2013
    ..Senior-Loken Syndrome, Primary Ciliary Dyskinesia, Nephronophthisis, Retinitis Pigmentosa, and Polycystic Kidney Diseases (PKD). PKD itself affects 1 in 1,000 individuals ultimately requiring dialysis and transplantation...
  10. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ..establish myself as an independent investigator in the field of kidney research, focusing on animal models of kidney diseases. The training (K99) phase of this award will be mentored by Dr...
  11. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2013
    ..to test the hypothesis that ADMA mediates the effects of ROS on blood vessels and proximal tubular transport which could lead to new targets for intervention to prevent progressive cardiovascular and kidney diseases.
  12. Financial Risks and Ethnic/Racial Disparities in Live Kidney Donation
    TANJALA PURNELL; Fiscal Year: 2011
    ..research objectives are closely aligned with the National Institute of Diabetes and Digestive and Kidney Diseases end-stage renal disease target focus of improving rates of kidney transplantation and donation, particularly ..
  13. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Challenge Area - (11) Regenerative Medicine Specific challenge topic - 11-DK-101 Promote regeneration and ..
  14. Regulation of Bone Mineralization in Renal Osteodystrophy
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012
    ..Furthermore, recently, the Kidney Diseases Improving Global Outcomes (KDIGO) recommended the assessment of three areas of bone histology--bone turnover, ..
  15. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    John H Streiff; Fiscal Year: 2010
    ..salt and blood pressure, often in the kidney, are routinely involved in renal hypertensive disorders, chronic kidney diseases with hypertension, and vascular diseases...
  16. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    Erik Schwiebert; Fiscal Year: 2009
    ..salt and blood pressure, often in the kidney, are routinely involved in renal hypertensive disorders, chronic kidney diseases with hypertension, and vascular diseases...
  17. Sphingosine 1 phosphate receptors 1 and 3 as novel targets in transplantation
    Amandeep Bajwa; Fiscal Year: 2013
    ..goal of establishing and funding an independent laboratory focused on cures and treatments for chronic kidney diseases. The results of this research project will be used in the preparation of an independent NIH funded R01 ..
  18. Use of small molecules that stabilize dynamin rings in podocytopathies
    Sanja Sever; Fiscal Year: 2013
    ..In the United States alone, glomerular kidney diseases affect some 20 million people, and this number has roughly doubled in the last two decades...
  19. Genetic analysis of the ciliopathies ARPKD and Meckel syndrome
    Peter C Harris; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the last few years it has become clear that polycystic kidney diseases (PKDs) are ciliopathies, due to mutations in cilia related genes...
  20. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..Nevertheless, several pathological processes appear to be common across progressive kidney diseases of diverse etiologies, including progressive tubulointerstitial fibrosis, tubular atrophy, glomerulosclerosis,..
  21. Role of the complement system in renal disease
    Richard J Quigg; Fiscal Year: 2011
    ..The goal of this work is to understand the root cause of human kidney diseases through the use of animal and cell culture model systems...
  22. FASEB on Biology of Cilia and Flagella
    Bradley K Yoder; Fiscal Year: 2010
    ..Dyskinesia, Joubert Syndrome, Alstrom Syndrome, Retinitis Pigmentosa, Nephronophthisis, and Polycystic Kidney Diseases (PKD) are disorders of the primary cilium...
  23. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2013
    ..establish myself as an independent investigator in the field of kidney research, focusing on animal models of kidney diseases. The training (K99) phase of this award will be mentored by Dr...
  24. STUDIES ON THE STRUCTURE OF BASEMENT MEMBRANES
    BILLY GERALD HUDSON; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Kidney diseases such as diabetic nephropathy, Goodpasture syndrome, and Alport syndrome directly affect the normal ..
  25. Visceral Adipose Tissue as Mediator amid Lifestyle Factors &Cardiometabolic Risk
    KRISTEN GILL HAIRSTON; Fiscal Year: 2013
    ..In response to PA 09-133 (Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases), we propose to explore innovative, longitudinal hypotheses through the use of existing data sets and new ..
  26. Interplay between metabolism and FXR activation in scoparone signaling
    Bingfang Yan; Fiscal Year: 2013
    ..Yin Chin (artemisiae scopariae), a Chinese herb that has been used for thousands of years to treat liver and kidney diseases. Yin Chin preparations have received much attention worldwide lately and are marketed as health supplements ..
  27. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..pulmonary disease, nervous system disorders (multiple sclerosis, Parkinson Disease, spinal cord injury), kidney diseases and more. Current methods for the preservation of MSCs are suboptimal...
  28. Clinical utility of extracellular RNA as marker of kidney disease progression
    Thomas Tuschl; Fiscal Year: 2013
    ..This permits discovery of biomarkers capable of predicting progression across the spectrum of kidney diseases as mechanisms of CKD progression are to a largely independent of CKD etiology...
  29. Alpha actinin 4: its functions and regulation
    Hung Ying Kao; Fiscal Year: 2013
    ..We anticipate that our studies will uncover a previously underappreciated role for ACTN4 that is critical for podocyte functions and may have future therapeutic implications in kidney diseases.
  30. Role of GLIS2 in the Development of Cystic Kidney Disease
    Massimo Attanasio; Fiscal Year: 2013
    ..effectors that are deregulated in Glis2 knockout kidneys has gained even more importance, and is likely to produce further insights in the complex regulatory network that is altered in our model of cystic kidney diseases and fibrosis.
  31. Role of micro RNAs in renin cell differentiation
    ROBERTO ARIEL GOMEZ; Fiscal Year: 2013
    ..Information gained from the proposed studies may help children and adults affected by kidney diseases and hypertension.
  32. RENAL DISEASE
    MARC RANDALL HAMMERMAN; Fiscal Year: 2013
    ..of renal chemistry assays of blood and urine to aid in the analysis of animal models of genetic and acquired kidney diseases;provides equipment and support for analyzing renal development, morphology and histopathology by fluorescence,..
  33. Training Program in Hypertension, Kidney Disease &Cell Biology
    Christie P Thomas; Fiscal Year: 2013
    ..applicant): This application proposes continued funding for an interdisciplinary research training program in kidney diseases, hypertension, and cell biology...
  34. Proteinuria causes progressive kidney disease by impairing autophagy
    Andrea Havasi; Fiscal Year: 2013
    ..and help me make a significant contribution to the depth and breadth of research in the field of proteinuric kidney diseases. I believe that this NIH mentored award will promote my scientific maturity and allow me to transition to a ..
  35. Mechanisms of glomerular disesase progression
    Jeffrey R Schelling; Fiscal Year: 2012
    ..mesangial cell culture models, which can be more easily manipulated, upon completion of this project;we hope to provide new information about the kidney beta-8 integrin, which could lead to new therapies for chronic kidney diseases.
  36. Development of the renin-expressing cell
    Maria L Sequeira Lopez; Fiscal Year: 2010
    ..This work has the potential to open new avenues for the understanding, prevention and treatment of hypertension, birth defects and kidney diseases.
  37. Nano-Antioxidants as a Therapeutic for Preclinical Models of NAFLD
    Robia G Pautler; Fiscal Year: 2013
    ..According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), it is the most common form of chronic liver disease and with the risk factors of obesity, diabetes, ..
  38. The role of DNA damage response signaling in chronic kidney disease
    Rannar Airik; Fiscal Year: 2013
    ..Medical Institute and internationally recognized leader in the fields of human genetics and of pediatric kidney diseases. In March 2013 I will move to the Boston Children's Hospital (BCH)/Harvard Medical School (HMS) with Dr...
  39. A Model for Nephronophthisis in Caenorhabditis elegans
    Maureen M Barr; Fiscal Year: 2013
    ..NPHP and other cystic kidney diseases are associated with defects in cilia...
  40. Three-dimensional Human Kidney Tissue System for Studying Renal Diseases
    Jeannine Coburn; Fiscal Year: 2013
    ..other kidney structures and inflammatory cells to engineer a more complete kidney and more extensively model kidney diseases. Furthermore, the model can be extended to the engineering of other organs further broadening its ..
  41. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2013
    ..HNF-1[unreadable]) and its roles in the regulation of kidney-specific gene expression and cystic kidney diseases. HNF-1[unreadable] is a DNA-binding transcription factor that regulates tissue-specific gene expression in ..
  42. Role of KLF15 in podocyte differentiation
    Sandeep Mallipattu; Fiscal Year: 2012
    Podocyte injury resulting from a loss of podocyte differentiation has been implicated in many kidney diseases such as Focal Segmental Glomerular Sclerosis (FSGS) and HIV Associated Nephropathy (HIVAN)...
  43. Regulation of Genes Encoding Flagellar Proteins in Chlamydomonas reinhardtii
    JASON MITCHELL BROWN; Fiscal Year: 2010
    ..Many disorders, including polycystic kidney diseases and primary ciliary diskinesia, result from loss or malfunction of cilia...
  44. Role of Ca2+/calmodulin kinases in skeletal muscle glucose transport and growth.
    CAROL WITCZAK; Fiscal Year: 2013
    ..e. diabetes), cancer, chronic lung, heart and kidney diseases, and AIDS;and in these disease states skeletal muscle wasting significantly contributes to disease mortality ..
  45. Reducing geographic disparity in transplant access: Clinical and economic impact
    Krista L Lentine; Fiscal Year: 2010
    ..3) To estimate the economic impact of a novel sharing system on costs of care for end-stage liver and kidney diseases. Linkages of clinical data in the OPTN registry will be performed with financial data from Medicare, private ..
  46. Neighborhood Characteristics and Body Mass Index: Selection or Causation?
    Ken Smith; Fiscal Year: 2009
    ..responsive to several goals described in (PA-06-151) "Secondary Analyses in Obesity, Diabetes, Digestive &Kidney Diseases." Using the UPDB for this project is cost-effective because it already links longitudinal data on demographic ..
  47. Multiphoton imaging of the juxtaglomerular apparatus
    Janos Peti-Peterdi; Fiscal Year: 2013
    ..can be used to develop new drugs and therapeutic approaches for the better treatment of cardiovascular and kidney diseases. PUBLIC HEALTH RELEVANCE Hypertension is a major risk factor for cardiovascular diseases, affecting about 25% ..
  48. Microvascular Endothelial Cells in the Pathogenesis of Chronic Kidney Injury
    Ikuyo Yamaguchi; Fiscal Year: 2011
    ..how renal peritubular capillaries contribute to renal fibrosis, the final common pathway of all chronic kidney diseases. The proposed studies will investigate mechanisms that control peritubular capillary permeability, a major ..
  49. Beyond Adiposity: Insulin and Inflammation in Postmenopausal Breast Cancer
    Nomeli Nunez; Fiscal Year: 2009
    ..Dr. Nunez received post-doctoral training at the National Institute of Diabetes and Kidney Diseases and subsequently at the National Cancer Institute, in the prestigious Cancer Prevention Fellowship Program...
  50. Discover and functionally characterize full-penetrance causes of nephrosis/FSGS
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..Chronic kidney diseases (CKD) take one of the highest tolls on human health, and their prevalence has been rising in the last 20 ..
  51. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA'AYAN; Fiscal Year: 2013
    ..While gene expression microarray has been widely applied for the study of kidney diseases, data analytical tools are quite limited...
  52. Novel role of AQP2 in cell migration and kidney tubular injury and repair
    HUA A LU; Fiscal Year: 2013
    ..of AQP2 has been frequently reported in a variety of transgenic animal models and in patients with polycystic kidney diseases with polyuria and coexisting structural and functional defects of the kidney tubules...
  53. Mayo Translational PKD Center (MTPC)
    Vicente E Torres; Fiscal Year: 2013
    ..that include a Center for Translational Science Activities (CTSA) grant (with a NIH Training Grant in Kidney Diseases), and complementary institutional cores that include the Genomics Resource Center, Proteomics Research Center,..
  54. Glucocorticoid Receptor Function in Steroid Resistant Childhood Nephrotic Syndrom
    JORGE A INIGUEZ LLUHI; Fiscal Year: 2010
    ..Syndrome, characterized by massive proteinuria, hypoalbuminemia and edema, is one of the most frequently seen kidney diseases in children...
  55. Identifying urinary biomarkers for early type 2 diabetic nephropathy
    Maryam Afkarian; Fiscal Year: 2013
    ..protein composition and how it is changed in the disease state) has been used to identify markers for several kidney diseases. Dr...
  56. New genes and pathomechanisms of congenital abnormalities of the kidney (CAKUT)
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..Chronic kidney diseases (CKD) take one of the highest tolls on human health, requiring dialysis or kidney transplantation for ..
  57. H3Africa Kidney Disease Research Network
    Akinlolu O Ojo; Fiscal Year: 2013
    ..single gene mutation kidney disorders in affected families, genetic variants of single genes associated with kidney diseases in the populations and genome wide association studies;(3) establish two low-capital intensity, rugged and ..
  58. Characterization of a novel protein required for glomerular podocyte function
    LORI L O'BRIEN; Fiscal Year: 2012
    ..molecules involved in maintaining these attachments, and may lead to novel therapeutic targets for various kidney diseases. These goals directly relate to the mission of the NIH/NIDDK to improve human health through novel research, ..
  59. The Role of Bicaudal-C in Polycystic Kidney Disease
    Oliver Wessely; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycystic Kidney Diseases (PKD) are the leading cause of end-stage renal failure and are characterized by the development of renal cysts along the entire length of the nephron...
  60. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..In 2002, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) stated that 20,000 individuals in the US were supported by PN for intestinal failure and of these, ..
  61. Role of the novel gene fam4b in phosphatidylserine synthesis in podocytes and mai
    HUA A LU; Fiscal Year: 2012
    ..We proposed to examine the underlying mechanism of this gene and understand its contribution to the pathophysiology of "leaky" kidney diseases.
  62. Cell junction proteins in podocyte injury repair
    Jeffrey Simske; Fiscal Year: 2013
    ..during foot process effacement results in proteinuria and contributes to the progression of many chronic kidney diseases such as diabetes and HIV-associated nephropathy...
  63. Training Grant in Academic Nephrology
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2013
    ..bioengineering, nanotechnology, tissue engineering, regenerative biology, and immunological mechanisms in kidney diseases. In addition, there is a large program in clinical and translational transplantation immunology...
  64. GDNF and Ret are critical for glomerular development, maintenance, and protection
    CYNTHIA TSUI; Fiscal Year: 2013
    ..interface, are the predominant cell type affected by diabetic nephropathy and other non-diabetic glomerular kidney diseases. Podocyte loss, either by cell death or detachment, is directly related to the progression of glomerular ..
  65. CYSTIC DILATATION OF NEPHRONS IN TRANSGENIC INV MICE
    Carrie Phillips; Fiscal Year: 2005
    ..Inherited polycystic kidney diseases (PKD) of childhood include nephronophthisis, autosomal recessive polycystic kidney disease and medullary ..
  66. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..Mentored Research Scientist Development Award (K01) from the National institute of Diabetes and Digestive and Kidney Diseases (NIDDK)...
  67. Screening for Inhibitors of the Integrated Stress Response
    David Ron; Fiscal Year: 2007
    ..degradation accounts for lack of enzymes in lysosomal storage diseases or membrane transporters in certain kidney diseases. The protein folding environment in the ER is regulated by signal transduction pathways that together ..
  68. Podocyte Protein Alterations Induced by Glucocorticoids
    Richard Ransom; Fiscal Year: 2005
    Nephrotic syndrome (NS) is one of the most common kidney diseases seen in children...
  69. ROLE OF LEUKOCYTES IN OBSTRUCTIVE NEPHROPATHY
    Saulo Klahr; Fiscal Year: 1992
    ..Cellular infiltration of the renal interstitium is a feature of a number of kidney diseases and may be a prominent histological manifestation in a number of entities leading to chronic renal failure...
  70. Stem Cells in Organ Maintenance and Repair
    Lloyd Cantley; Fiscal Year: 2006
    ..to perform studies that will determine the usefulness of stem cells in treating patients with a variety of kidney diseases. Stem cells have attracted a vast degree of attention and interest in the biomedical research community...
  71. A forward genetic screen for PKD pathways in mice using the PiggyBac transposon
    Stefan Somlo; Fiscal Year: 2010
    ..A critical step for promoting deeper scientific understanding of the factors underlying polycystic kidney diseases and for promoting interest in efforts to develop therapies, is to achieve a compelling and precise definition ..
  72. Ninth International Primary Hyperoxaluria Workshop
    Ross P Holmes; Fiscal Year: 2010
    ..It often has a late diagnosis due to the similarity of symptoms to stone disease and other kidney diseases. There is no known cure apart from a small percentage of individuals who respond completely to pyridoxine ..
  73. MEDICAL THERAPY FOR BPH--DATA COORDINATING CENTER
    PAMELA BURROWS; Fiscal Year: 2001
    ..proposes to work in cooperative agreement with the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK-NIH) to serve as the Data Coordinating Center (DCC) for a proposed multi-center clinical trial of the ..
  74. VITAMIN D--CHEMICAL AND RELATED STUDIES
    WILLIAM OKAMURA; Fiscal Year: 2001
    ..g. their use in treating various cancers (breast, colon and prostate cancers as well as leukemia), bone and kidney diseases (osteoporosis, renal osteodystrophy), skin diseases (psoriasis), neurological disorders (Alzheimer's disease),..