Genomes and Genes
polycystic kidney diseases
Summary: Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.
Publications221 found, 100 shown here
- Intraflagellar transportJoel L Rosenbaum
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Nat Rev Mol Cell Biol 3:813-25. 2002..Recent results indicate that defects in IFT might be a primary cause of some human diseases...
- MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisCorey L Williams
Department of Cell Biology, University of Alabama, Birmingham, AL 35294, USA
J Cell Biol 192:1023-41. 2011....
- Polycystic kidney diseasePeter C Harris
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
Annu Rev Med 60:321-37. 2009..Rare, syndromic forms of PKD also include defects of the eye, central nervous system, digits, and/or neural tube and highlight the role of cilia and pathways such as Wnt and Hh in their pathogenesis...
- The primary cilium as the cell's antenna: signaling at a sensory organelleVeena Singla
Program in Developmental and Stem Cell Biology, and Diabetes Center, University of California, San Francisco, CA 94143 0525, USA
Science 313:629-33. 2006....
- Cyclic AMP-mediated cyst expansionDarren P Wallace
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA
Biochim Biophys Acta 1812:1291-300. 2011..This article is part of a Special Issue entitled: Polycystic Kidney Disease...
- Polycystic kidney diseasePatricia D Wilson
Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
N Engl J Med 350:151-64. 2004
- Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney diseasePriyanka Pandey
Department of Medicine, Children s Hospital Boston Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
BMC Syst Biol 5:56. 2011..miRNAs are small, regulatory non-coding RNAs, implicated in a wide spectrum of biological processes. Their expression levels are altered in several diseases including kidney cancer, diabetic nephropathy and PKD...
- Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney diseaseHiroko Togawa
Department of Pediatrics, Wakayama Medical University, Wakayama, Japan
Am J Physiol Renal Physiol 300:F511-20. 2011..Our study clarified the nephron segment-specific cyst profile related to EMT in PCK rats. EMT may play a key role in polycystic kidney disease...
- The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney diseaseJonathan M Shillingford
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
Proc Natl Acad Sci U S A 103:5466-71. 2006..These results indicate that PC1 has an important function in the regulation of the mTOR pathway and that this pathway provides a target for medical therapy of ADPKD...
- Polycystic kidney disease and therapeutic approachesEun Young Park
Department of Biological Science, Sookmyung Women s University, Seoul 140 742, Korea
BMB Rep 44:359-68. 2011..In this review, we will discuss recent approaches to PKD therapy. It provides important information regarding potential targets for PKD...
- A transcriptional network in polycystic kidney diseaseLionel Gresh
Unité Expression Génétique et Maladies CNRS URA 1644, Departement de Biologie du Developpement, Institut Pasteur, Paris, France
EMBO J 23:1657-68. 2004..This may explain the increased proliferation of cystic cells in MODY5 patients carrying autosomal dominant mutations in HNF1beta...
- Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney diseaseYunxia Tao
Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Renal Box C281, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 102:6954-9. 2005....
- A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidneyZhaoxia Sun
MIT, Center for Cancer Research and Biology Department, Building E17 Room 340, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Development 131:4085-93. 2004..Our results also suggest that lesions in genes involved in cilia formation and function are the predominant cause of cystic kidney disease, and that the genes identified here are excellent candidates for novel human PKD genes...
- Putative roles of cilia in polycystic kidney diseasePaul Winyard
UCL Institute of Child Health, London, WC1N 1EH, UK
Biochim Biophys Acta 1812:1256-62. 2011..Understanding how cilia fit into the other aspects of polycystic kidney disease biology is the challenge for the next decade. This article is part of a Special Issue entitled: Polycystic Kidney Disease...
- The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activityUyen Tran
Department of Cell Biology and Anatomy, LSU Health Sciences Center, MEB 6A12, 1901 Perdido Street, New Orleans, LA 70112, USA
Development 137:1107-16. 2010..Based on these data, we propose that the kidney phenotype in Bicc1(-/-) mutant mice is caused by dysregulation of a microRNA-based translational control mechanism...
- Increased expression of secreted frizzled-related protein 4 in polycystic kidneysDaniel Romaker
Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
J Am Soc Nephrol 20:48-56. 2009..Taken together, these observations suggest a potential role for SFRP4 in the pathogenesis of ADPKD...
- Animal models for human polycystic kidney diseaseShizuko Nagao
Education and Research Center of Animal Models for Human Diseases, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
Exp Anim 61:477-88. 2012..Therefore, experimental animal models are indispensable for investigating molecular mechanisms of PKD onset and progression as well as potential therapeutic treatments...
- Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF/Raf/MAPK/ERK signaling pathwayTao Xu
Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Mol Biol Rep 39:7743-53. 2012..CXB can inhibit proliferation, suppress cell cycle progression, and induce apoptosis in ADPKD cyst-lining epithelial cells through the inhibition of the VEGF/VEGFR-2/Raf-1/MAPK/ERK signaling pathway...
- Modifier genes play a significant role in the phenotypic expression of PKD1Pamela R Fain
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Kidney Int 67:1256-67. 2005..There are significant familial phenotype differences; but it is not clear if this is due to differences in PKD1 mutations, differences in genetic background, or both...
- Overexpression of innate immune response genes in a model of recessive polycystic kidney diseaseM Mrug
Division of Genetic and Translational Medicine, Department of Medicine, The University of Alabama at Birmingham, 720 20th Street South, Birmingham, AL 35294, USA
Kidney Int 73:63-76. 2008..We also found elevated complement component 3 activation in two other mouse-recessive models and human-recessive PKD. Our results suggest that abnormal complement component 3 activation is a key element of progression in PKD...
- Disruption of a ciliary B9 protein complex causes Meckel syndromeWilliam E Dowdle
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 94158, USA
Am J Hum Genet 89:94-110. 2011..Our data indicate that B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization and that B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes MKS...
- Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cellsTamio Yamaguchi
Kidney Institute, Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, MSN 3018, Kansas City, KS 66160, USA
J Am Soc Nephrol 17:178-87. 2006..Thus, increases in [Ca2+]i are able to restore the normal anti-mitogenic response to cAMP in cells that are derived from two genetically distinct forms of PKD...
- A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formationSorin V Fedeles
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
Nat Genet 43:639-47. 2011....
- Loss of oriented cell division does not initiate cyst formationSaori Nishio
Section of Nephrology, Yale University School of Medicine, P O Box 208029, 333 Cedar Street, New Haven, CT 06520 8029, USA
J Am Soc Nephrol 21:295-302. 2010..In conclusion, loss of oriented cell division is a feature of Pkhd1 mutation and cyst formation, but it is neither sufficient to produce kidney cysts nor required to initiate cyst formation after mutation in Pkd1 or Pkd2...
- Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney diseaseP M Vassilev
Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA
Biochem Biophys Res Commun 282:341-50. 2001..The dysfunction of such mutants may result in defective coupling of PC2 to intracellular Ca(2+) homeostasis associated with the pathogenesis of ADPKD...
- Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney diseaseB D Cowley
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Kidney Int 73:251-3. 2008..Data regarding use of CCBs in human polycystic kidney disease (PKD) are limited and mixed. Thus, it is premature to extrapolate these findings to human PKD...
- A mitotic transcriptional switch in polycystic kidney diseaseFrancisco Verdeguer
Gene Expression, Development and Disease Laboratory, Developmental Biology Department, Institut Pasteur, Paris, France
Nat Med 16:106-10. 2010..This association suggests that HNF-1beta is a bookmarking factor that is necessary for reopening the chromatin of target genes after mitotic silencing...
- Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK ratsCatharina Renken
Department of Pediatrics, University Children s Hospital, Rostock, Rostock, Germany
Nephrol Dial Transplant 26:92-100. 2011..We examined the effects of sirolimus in PCK rats, an orthologous animal model of human ARPKD...
- Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategiesO Ibraghimov-Beskrovnaya
Cell Biology, Genzyme Corporation, 5 Mountain Road, Framingham, MA 01701 9322, USA
Cell Mol Life Sci 65:605-19. 2008b>Polycystic kidney diseases (PKDs) represent a large group of progressive renal disorders characterized by the development of renal cysts leading to end-stage renal disease...
- Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD)Franck Belibi
Division of Renal Diseases and Hypertension, University of Colorado at Denver and Health Sciences Center, Aurora, 80262, USA
Am J Physiol Renal Physiol 300:F1235-43. 2011..The first demonstration of autophagosomes in PKD kidneys is reported. Inhibition of HIF-1α did not have a therapeutic effect...
- bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestineS Kamada
Department of Medical Genetics, Biomedical Research Center, Osaka University Medical School, Yamadaoka, Japan
Cancer Res 55:354-9. 1995..Our bcl-2-/- mice also revealed novel defects in the small intestine, characterized by retarded development, accelerated exfoliation of epithelial cells, and very few mitotic progenitor cells...
- Polycystic kidney disease prevented by transgenic RNA interferenceP Bouillet
Cell Death Differ 12:831-3. 2005
- Molecular genetics of polycystic kidney diseaseJ P Calvet
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, USA
J Nephrol 11:24-34. 1998....
- Increased water intake decreases progression of polycystic kidney disease in the PCK ratShizuko Nagao
Education and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi, Japan
J Am Soc Nephrol 17:2220-7. 2006..It is suggested that limiting serum AVP levels by increased water intake may be beneficial to some patients with PKD...
- Murine congenital polycystic kidney disease: a model for studying development of cystic diseaseG M Preminger
J Urol 127:556-60. 1982
- Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortalityR D Perrone
Divisions of Nephrology and Clinical Care Research, Department of Medicine, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
Am J Kidney Dis 38:777-84. 2001..Mortality secondary to extrarenal complications was substantially lower than that secondary to cardiovascular or cerebrovascular disease...
- Apico-basal polarity in polycystic kidney disease epitheliaPatricia D Wilson
UCL Medical School, Royal Free Hospital, London, UK
Biochim Biophys Acta 1812:1239-48. 2011..This article is part of a Special Issue entitled: Polycystic Kidney Disease...
- Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneysA Atala
Division of Urology, Children s Hospital, Boston, Massachusetts
Kidney Int 43:1081-5. 1993..The study of these five mutations and their interactions should prove useful for understanding the mechanisms required to maintain the normal integrity of renal tubules...
- What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)?Charles L Edelstein
Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Cell Cycle 4:1550-4. 2005..Thus, there is evidence that both epithelial cell apoptosis and proliferation are dysregulated in ADPKD and may represent a general mechanism for cyst growth...
- Matrix metalloproteinase-2 in a murine model of infantile-type polycystic kidney diseaseC A Rankin
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66160 7400, USA
J Am Soc Nephrol 10:210-7. 1999..MMP-2 was abnormally localized to the interstitium and to foci between cysts, suggesting that MMP-2 may regulate collagen accumulation at those sites, thus allowing cyst enlargement and limiting the severity of interstitial fibrosis...
- Cystic disease of the kidneyPatricia D Wilson
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Annu Rev Pathol 2:341-68. 2007....
- Defective planar cell polarity in polycystic kidney diseaseEvelyne Fischer
Gene Expression and Disease Unit, Centre National de la Recherche Scientifique CNRS FRE 2850, Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Nat Genet 38:21-3. 2006..These results suggest that oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation...
- The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and menJonathan M Lehman
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Dev Dyn 237:1960-71. 2008....
- Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney diseasePriyanka Pandey
Medical Research Center, University Hospital Mannheim, Mannheim, Germany
BMC Genomics 9:624. 2008..Although involvement of certain genes and transcriptional networks in PKD development has been shown, not much is known how they are regulated molecularly...
- Gene profiling of polycystic kidneysGisela Schieren
Renal Division, Department of Internal Medicine, Ruhr University Hospital Bochum at Marienhospital Herne, Freiburg, Germany
Nephrol Dial Transplant 21:1816-24. 2006..Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increased apoptosis and proliferation rates have been implicated in cystogenesis...
- Involvement of hypoxia-inducible transcription factors in polycystic kidney diseaseWanja Michael Bernhardt
Department of Nephrology and Hypertension, Friedrich Alexander University, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Am J Pathol 170:830-42. 2007..In conclusion, HIF accumulation in human and rat PKD seems to be responsible for increased EPO production and pericystic hypervascularity and may have an impact on progression of PKD...
- Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hairD J Veis
Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110
Cell 75:229-40. 1993..The abnormalities in these loss of function mice argue that Bcl-2 is a death repressor molecule functioning in an antioxidant pathway...
- Calcium signaling and polycystin-2Georgia I Anyatonwu
Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Biochem Biophys Res Commun 322:1364-73. 2004..Elucidation of the signaling pathway involved in normal PC1/PC2 function, the functional consequences of PC1/PC2 mutation, and the role of Ca2+ signaling will all help to unravel the molecular mechanisms of cystogenesis in PKD...
- Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney diseaseStephanie J Leuenroth
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 104:4389-94. 2007..We anticipate that small molecule induction of PC2-dependent calcium release is likely to be a valid therapeutic strategy for ADPKD...
- Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunitiesV E Torres
Division of Nephrology and Hypertension, Mayo College of Medicine, Rochester, MN 55905, USA
J Intern Med 261:17-31. 2007..This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation...
- Polycystins: from mechanosensation to gene regulationPatrick Delmas
Laboratoire de Neurophysiologie Cellulaire, CNRS UMR 6150, Faculte de Medecine, IFR Jean Roche, Bd Pierre Dramard, 13916 Marseille Cedex 20, France
Cell 118:145-8. 2004..This review focuses on the pros and cons of their candidacy as mechanically gated channels and on recent findings that have significantly advanced our physiological insight...
- Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathwaysJinsheng Gao
Department of Pharmacology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Lu, Haidian, Beijing, China
Eur J Pharmacol 654:92-9. 2011..These results define that curcumin inhibits renal cyst formation and enlargement and suggest that curcumin might be developed as a candidate drug for polycystic kidney disease...
- The mammalian Nek1 kinase is involved in primary cilium formationOhad Shalom
The Mina and Everard Goodman, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
FEBS Lett 582:1465-70. 2008Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as 'mitotic kinases'...
- Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epitheliumChao Nan Qian
Laboratories of Cancer Genetics and Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49508, USA
J Biol Chem 280:3938-45. 2005..Our results confirm an important role for proper regulation of Wnt/beta-catenin signaling in renal development and provide evidence that dysregulation of the pathway can initiate tumorigenesis in the kidney...
- Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilationBrenda S Magenheimer
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Am Soc Nephrol 17:3424-37. 2006....
- Mouse models of polycystic kidney disease induced by defects of ciliary proteinsJe Yeong Ko
Department of Biological Science, Sookmyung Women s University, Seoul 140 742, Korea
BMB Rep 46:73-9. 2013..In this review, we will describe the general role of cilia in renal epithelial cells, and the relationship between ciliary defects and PKD. We also discuss mouse models of PKD related to ciliary defects based on recent studies...
- Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney diseaseM V Rocco
Department of Medicine, University of Pennsylvania, Philadelphia 19104
Am J Physiol 262:F679-86. 1992....
- MicroRNAs regulate renal tubule maturation through modulation of Pkd1Vishal Patel
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, MC 8856, Dallas, TX 75390, USA
J Am Soc Nephrol 23:1941-8. 2012..In conclusion, miRNAs are essential for the maturation of renal tubules, and Pkd1 is a target of miR-200. These results also suggest that miRNAs may modulate PKD1 gene dosage and play a role in the initiation of cystogenesis...
- Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney diseaseB D Cowley
Department of Medicine, University of Kansas Medical Center, Kansas City 66103
Proc Natl Acad Sci U S A 84:8394-8. 1987The polycystic kidney diseases (PKDs) are a group of disorders characterized by the growth of epithelial cysts from the nephrons and collecting ducts of kidney tubules...
- Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy miceD D Woo
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1689, USA
J Clin Invest 100:1934-40. 1997..Characterization of these novel modifying loci may provide additional insights into the pathogenesis of polycystic kidney diseases.
- Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney diseaseW G Richards
Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
J Clin Invest 101:935-9. 1998..These results suggest that changes in the expression of the EGFR contribute to the formation of cysts in the collecting ducts, and that drugs that target the tyrosine kinase activity of the EGFR may potentially be therapeutic in ARPKD...
- Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney diseaseZlata Novalic
Department of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
J Am Soc Nephrol 23:842-53. 2012..Mechanisms to increase bioavailability or to target mTOR inhibitors more specifically to kidneys, alone or in combination with other compounds, may improve the potential for these therapies in PKD...
- Polycystic kidney disease at end-stage renal disease in the United States: patient characteristics and survivalK C Abbott
Nephrology Service, Walter Reed Army Medical Center, Washington, DC, 20307 5001, USA
Clin Nephrol 57:208-14. 2002..The patient characteristics and mortality associated with autosomal dominant polycystic kidney disease have not been characterized for a national sample of end-stage renal disease (ESRD) patients...
- Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney diseaseS Kuida
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 USA
Genome Res 10:49-54. 2000....
- Milder presentation of recessive polycystic kidney disease requires presence of amino acid substitution mutationsLaszlo Furu
Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
J Am Soc Nephrol 14:2004-14. 2003..The nature of the germline mutations in ARPKD plays a significant role in determining clinical outcome...
- Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse modelsThomas A Natoli
Department of Cell Biology, Genzyme Corporation, Framingham, Massachusetts, USA
Nat Med 16:788-92. 2010..Taken together, our data suggest that inhibition of GlcCer synthesis represents a new and effective treatment option for PKD...
- Meckelin is necessary for photoreceptor intraciliary transport and outer segment morphogenesisGayle B Collin
Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Invest Ophthalmol Vis Sci 53:967-74. 2012..In this study, the retinal morphology and ciliary function in a mouse model for Meckel Syndrome Type 3 (MKS3) throughout the course of photoreceptor development was examined...
- Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney diseaseErin E Olsan
Department of Molecular, Cellular and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 108:18067-72. 2011..Treatment of PKD mice with this drug leads to amelioration of the renal cystic disease similar to genetic STAT6 inactivation. These results suggest STAT6 as a promising drug target for treatment of ADPKD...
- Quantitative trait loci modulate renal cystic disease severity in the mouse bpk modelL M Guay-Woodford
Department of Medicine, University of Alabama at Birmingham, 35294, USA
J Am Soc Nephrol 11:1253-60. 2000..It is hypothesized that the gene encoding the polycystin-binding partner RGS7 is a candidate for the Chr 1 genetic modifier...
- Altered extracellular matrix component gene expression in murine polycystic kidneyI Ebihara
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
Ren Physiol Biochem 18:73-80. 1995..These data suggest that changes in the expression of basement membrane components and interstitial collagens are associated with the development of polycystic kidney disease...
- Expression of matrix metalloproteinase in the fluids of renal cystic lesionsHiroshi Harada
Division of Pathophysiological Science, Department of Pathology Pathophysiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Urol 168:19-22. 2002..We analyzed the expression of matrix metalloproteinase (MMP) in the fluids of benign and malignant renal cystic lesions to clarify matriolytic activities in the cyst...
- Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney diseaseHarold M Aukema
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, R3T 2N2
FASEB J 17:298-300. 2003..The altered levels of these eicosanoid-regulating enzymes has implications for the use of NSAIDS and specific COX inhibitors in individuals with this disorder...
- Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case reportNaoto Kuroda
Department of Pathology, Kochi Medical School, Japan
Int J Surg Pathol 12:171-7. 2004..Immunohistochemically, large esosinophilic inclusions were reactive for vimentin. Although these findings are rare in CDCs, they should be recognized in the pathologic spectrum of CDCs. Int J Surg Pathol 12(2):171-177, 2004..
- VEGF receptor inhibition slows the progression of polycystic kidney diseaseY Tao
Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
Kidney Int 72:1358-66. 2007..Our studies show that inhibition of VEGF function may be an important therapeutic option to delay the progression of polycystic kidney disease...
- c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interactionMartin Couillard
Institut de Recherches Cliniques de Montreal, Faculte de Medecine de l Universite de Montreal, Montreal, Quebec, H2W 1R7 Canada
Cancer Res 62:2210-4. 2002..Our study proves that c-myc-induced apoptosis can be independent of the FasL/Fas pathway in vivo and implicates the existence of a novel c-myc-driven apoptotic pathway...
- Genetic analysis of a quantitative trait in a mouse model of polycystic kidney diseaseO A Iakoubova
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 156:S72-7. 1997..This type of effect, which is an example of genetic epistasis, will make the molecular characterization of loci that contribute to complex traits markedly more difficult than the analysis of monogenic disorders...
- Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defectsW Lu
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 10:2385-96. 2001..Our data demonstrate for the first time that loss of polycystin-1 leads to cyst formation and defective skeletogenesis, and indicate that polycystin-1 is critical in both epithelium and chondrocyte development...
- Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotypeTamio Yamaguchi
Department of Biochemistry, The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Biol Chem 279:40419-30. 2004..We conclude that disruption of calcium mobilization in cells that are normally growth-inhibited by cAMP can derepress the B-Raf/ERK pathway, thus converting these cells to a phenotype that is growth-stimulated by cAMP...
- Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitineNikolay O Bukanov
Cell Biology, Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts 01701 9322, USA
Nature 444:949-52. 2006b>Polycystic kidney diseases (PKDs) are primarily characterized by the growth of fluid-filled cysts in renal tubules leading to end-stage renal disease...
- NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomesMoe R Mahjoub
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
J Am Soc Nephrol 16:3485-9. 2005A key feature of the polycystic kidney diseases is aberrant cell proliferation, a consequence of dysfunctional ciliary signaling...
- Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney diseaseFangming Lin
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 100:5286-91. 2003..Most generally, the phenotype of Kif3a mutant mice suggests a role for primary cilia in the maintenance of lumen-forming epithelial differentiation...
- A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegansM M Barr
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
Nature 401:386-9. 1999..PKD-2, the C. elegans homologue of PKD2, is localized to the same neurons as LOV-1, suggesting that they function in the same pathway...
- Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin geneS Saadi-Kheddouci
INSERM U129, ICGM, 24 rue du Faubourg St Jacques, 75014 Paris, France
Oncogene 20:5972-81. 2001....
- Advances in the pathogenesis and treatment of polycystic kidney diseaseVishal Patel
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Curr Opin Nephrol Hypertens 18:99-106. 2009..Mouse models of PKD, especially those with mutations in genes that are orthologous to human disease genes, have provided insights into the pathogenesis of cyst formation and advanced the preclinical testing of new drugs...
- Kidney development and disease in the zebrafishIain A Drummond
Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
J Am Soc Nephrol 16:299-304. 2005..This short review outlines recent progress in applying the zebrafish pronephros to issues of human health and development...
- Calcimimetic inhibits late-stage cyst growth in ADPKDVincent H Gattone
Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA
J Am Soc Nephrol 20:1527-32. 2009..The benefit of R-568 alone suggests calcium-sensing receptor modulation may have additional inhibitory effects on late-stage cyst growth resulting from a direct modulation of intracellular calcium...
- Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1Marcelo J Surpili
Centro de Biologia Molecular Estrutural CEBIME, Laboratorio Nacional de Luz Sincrotron LNLS, Rua Giuseppe Máximo Scolfaro 10 000, CP 6192, 13084 971 Campinas, SP, Brazil
Biochemistry 42:15369-76. 2003..Our results give further support to the previous observation that NEK1 is of functional importance for the etiology of PKD...
- [Polycystic kidney diseases: molecular genetics and counselling]James Lespinasse
Division de génétique médicale, Hopital Sainte Justine, Montreal, Quebec, Canada
Nephrol Ther 2:120-6. 2006..It permits to determine the type of transmission, to describe the course and the major complications of the disease and to explain currents therapeutics possibilities...
- Therapeutic potential of cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors in polycystic kidney diseaseHongyu Li
Department of Physiology and Pharmacology, University of Bristol, School of Medical Sciences, Bristol, UK
BioDrugs 23:203-16. 2009..The demonstration that CFTR inhibitors retard cyst expansion and kidney enlargement in mouse models of ADPKD provides proof of concept for the use of small-molecule CFTR inhibitors in the treatment of ADPKD...
- Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneysMasaya Baba
Urologic Oncology Branch, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Natl Cancer Inst 100:140-54. 2008..BHD encodes folliculin, a protein that may interact with the energy- and nutrient-sensing 5'-AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signaling pathways...
- Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing regionDai Shiba
Department of Anatomy and Developmental Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Cell Sci 122:44-54. 2009....
- Role of primary cilia in the pathogenesis of polycystic kidney diseaseBradley K Yoder
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Am Soc Nephrol 18:1381-8. 2007....
- Wnt signaling in polycystic kidney diseaseThomas Benzing
Renal Division, University Hospital Freiburg, Freiburg, Germany
J Am Soc Nephrol 18:1389-98. 2007..These spatial cues may be needed to position nascent tubules with a defined geometry...
- Polycystic kidney diseasePeter Igarashi
Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
J Am Soc Nephrol 18:1371-3. 2007
- Renal failure causes early death of bcl-2 deficient miceLev M Fedorov
Theodor Boveri Institut für Biowissenschaften, Biozentrum, Bayerische Julius Maximilians Universität, Am Hubland, 97074 Wurzburg, Germany
Mech Ageing Dev 127:600-9. 2006..Such models can be useful to study the influence of bcl-2 or other gene deficiency in individual organs (or tissues) on development and ageing of whole organism...
- Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney diseaseSayu Omori
Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Am Soc Nephrol 17:1604-14. 2006..These results demonstrate that the expression of MAPK is dysregulated in cyst epithelium and that inhibition of ERK slowed the progression of renal disease in pcy mice...
- In vitro cystogenesis: the search for drugs antagonizing cyst developmentOxana Ibraghimov-Beskrovnaya
Genzyme Corporation, 5, Mountain Road, Framingham, MA 01701 9322, Etats Unis
Nephrol Ther 2:S109-14. 2006..We have used in vitro cystogenesis assay for a high throughput screen of small molecule drugs and identified drugs specifically inhibiting cystogenesis but not tubulogenesis in vitro...
- The roles of cilia in developmental disorders and diseaseBrent W Bisgrove
Huntsman Cancer Institute Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
Development 133:4131-43. 2006..Here, we summarize an emerging view that in order to understand some complex developmental pathways and disease etiologies, one must consider the molecular functions performed by cilia...
- Cilia: tuning in to the cell's antennaWallace F Marshall
Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
Curr Biol 16:R604-14. 2006..While these diseases highlight the pivotal roles of cilia in physiology and development, the mechanistic link between cilia, physiology, and disease remains unclear...
- Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specificationMaria Immacolata Ferrante
Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
Nat Genet 38:112-7. 2006....
- Genetics and pathogenesis of polycystic kidney diseasePeter Igarashi
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Am Soc Nephrol 13:2384-98. 2002
- FASEB SRC onBradley K Yoder; Fiscal Year: 2013..ALS), Senior-Loken Syndrome, Primary Ciliary Dyskinesia, Nephronophthisis, Retinitis Pigmentosa, and Polycystic Kidney Diseases (PKD). PKD itself affects 1 in 1,000 individuals ultimately requiring dialysis and transplantation...
- Genetic analysis of the ciliopathies ARPKD and Meckel syndromePeter C Harris; Fiscal Year: 2013DESCRIPTION (provided by applicant): In the last few years it has become clear that polycystic kidney diseases (PKDs) are ciliopathies, due to mutations in cilia related genes...
- FASEB on Biology of Cilia and FlagellaBradley K Yoder; Fiscal Year: 2010..Ciliary Dyskinesia, Joubert Syndrome, Alstrom Syndrome, Retinitis Pigmentosa, Nephronophthisis, and Polycystic Kidney Diseases (PKD) are disorders of the primary cilium...
- Regulation of Genes Encoding Flagellar Proteins in Chlamydomonas reinhardtiiJASON MITCHELL BROWN; Fiscal Year: 2010..Many disorders, including polycystic kidney diseases and primary ciliary diskinesia, result from loss or malfunction of cilia...
- Novel role of AQP2 in cell migration and kidney tubular injury and repairHUA A LU; Fiscal Year: 2013..of AQP2 has been frequently reported in a variety of transgenic animal models and in patients with polycystic kidney diseases with polyuria and coexisting structural and functional defects of the kidney tubules...
- The Role of Bicaudal-C in Polycystic Kidney DiseaseOliver Wessely; Fiscal Year: 2013DESCRIPTION (provided by applicant): Polycystic Kidney Diseases (PKD) are the leading cause of end-stage renal failure and are characterized by the development of renal cysts along the entire length of the nephron...
- A forward genetic screen for PKD pathways in mice using the PiggyBac transposonStefan Somlo; Fiscal Year: 2010..A critical step for promoting deeper scientific understanding of the factors underlying polycystic kidney diseases and for promoting interest in efforts to develop therapies, is to achieve a compelling and precise ..
- FASEB SRC on "Polycystic Kidney Disease, From Bench to Bedside"Dorien J M Peters; Fiscal Year: 2011..b>Polycystic kidney diseases are a group of inherited disorders that result in cyst development in the kidney often resulting in end ..
- Molecular Basis of Polarized ExocytosisWei Guo; Fiscal Year: 2012..of exocytosis, and contribute to our understanding of diseases such as neurological degeneration, polycystic kidney diseases, and cancer...
- Mechanisms of Polycystin and Cilia Function in ADPKDStefan Somlo; Fiscal Year: 2013..Last, First, Middle): Somlo, Stefan Project Summary/Abstract The functional connection between human polycystic kidney diseases and cilia is based in part on the overlap between genes whose mutation results in kidney cyst formation ..
- Center for Polycystic Kidney Disease Research at YaleMichael J Caplan; Fiscal Year: 2013..at Yale is to facilitate translational research that will advance the understanding and treatment of polycystic kidney diseases. The Center will provide investigators both at Yale and across the country with access to highly ..
- CYSTIC DILATATION OF NEPHRONS IN TRANSGENIC INV MICECarrie Phillips; Fiscal Year: 2005..Inherited polycystic kidney diseases (PKD) of childhood include nephronophthisis, autosomal recessive polycystic kidney disease and medullary ..
- Xenopus Bicaudal-C a Model for Polycystic Kidney DiseaseOliver Wessely; Fiscal Year: 2007b>Polycystic Kidney Diseases (PKD) are the leading cause of end-stage renal failure and require extensive treatments, such as dialysis and kidney transplantation...
- Characterization of the Murine pcy MutationDavid Woo; Fiscal Year: 2005b>Polycystic kidney diseases (PKD) are among the leading causes of progressive renal failure in children and adults. Currently, there is no known therapy that can inhibit or retard the progression to renal failure in PKD patients...
- Molecular Genetics and Pathogenesis of ARPKDGuanqing Wu; Fiscal Year: 2004..Taken together, the results of these studies will significantly advance our understanding of the pathogenesis of polycystic kidney diseases and the molecular mechanism of cyst formation and growth.
- MECHANISM OF EGF RECEPTOR MISSORTING IN PKDSanjay Pimplikar; Fiscal Year: 1999..In Polycystic Kidney Diseases, a group of disorders characterized by the progressive formation of renal cysts, several membrane ..
- Molecular networks: programming normal renal development and modeling disease patLisa Guay Woodford; Fiscal Year: 2007..The meeting will be held in Pecs, Hungary from August 27-30, 2007, immediately preceding the 14th IPNA Congress in Budapest, Hungary (August 31- September 4, 2007). [unreadable] [unreadable] [unreadable]..
- Cystin, a lipid raft and cilia-associated protein in PKDLisa Guay Woodford; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- FASEB Conference -PKD Mechanisms and Clinical ImpactLisa Guay Woodford; Fiscal Year: 2005..for the Federation of American Societies of Experimental Biology (FASEB) Summer Research Conference on "Polycystic Kidney Diseases: Molecular Pathways, Pathogenic Mechanisms and Translational Applications" to be held from August 6-11, ..
- Genetics and Pharmacogenetics in FSGS (PPG Project 4)Lisa Guay Woodford; Fiscal Year: 2007..unreadable]..
- Novel Therapeutic Strategies for PKDPatricia Wilson; Fiscal Year: 2007b>Polycystic kidney diseases (PKD) affect greater than or equal too 500,000 patients in the US and > 6 million worldwide, but the only form of "therapy" is renal replacement by dialysis or transplantation...
- Cilial dysfunction and pathogenesis of obesityBradley K Yoder; Fiscal Year: 2010....
- REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSIONPeter Igarashi; Fiscal Year: 2010..abstract_text> ..
- Pathogenesis of wpk-induced Renal and Cerebral DiseaseVincent Gattone; Fiscal Year: 2008..abstract_text> ..
- Pathogenesis of PKD in Mice Lacking Renal CiliaPeter Igarashi; Fiscal Year: 2008....
- Roles of polycystin and calcium in B-Raf signalingDARREN WALLACE; Fiscal Year: 2004..2) Determine the mechanism by which the overexpression of the C-terminal fragment of PC1 in M1 cells, a condition thought to disrupt PC1/PC2 function, alters cAMP-dependent B-Raf signaling. ..
- TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEYBradley Yoder; Fiscal Year: 2003..Overall, results generated from this proposal will give important insight into the biological function of Tg737 and how disruption of the Tg737/polycystin-1 signaling pathway results in the formation of renal cyst. ..
- Transgene Induced HIV-Associated NephropathyVincent Gattone; Fiscal Year: 2004..By studying this HIV-transgenic rat, we should be able to identify additional factors that contribute to the HIV-induced phenotype in GECs and provide new information that will lead to a rational treatment for HIVAN. ..
- Epithelial Cell Linage in the Kidney and Genitourinary TractPeter Igarashi; Fiscal Year: 2007....
- Conserved Mechanisms of CiliogenesisBradley Yoder; Fiscal Year: 2007..abstract_text> ..
- TRANSCRIPTION FACTORS AND RENAL DEVELOPMENTPeter Igarashi; Fiscal Year: 2002..Collectively, these studies should provide fundamental insights into transcriptional regulation of kidney morphogenesis and cystogenesis. ..
- High Pressure Freezing and Processing UnitVincent Gattone; Fiscal Year: 2005..The research and physical environment, EM Center personnel and IU School of Medicine institutional support make the IU EM Center an excellent place for the appropriate use of the Leica HPF and Processor System. ..
- MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIAAlan Verkman; Fiscal Year: 2008..Methods will include fluorescence photobleaching recovery, energy transfer and ratio imaging. Also, specific water/solute transporting properties (Pd, c^)of the mammalian aquaporins will be measured. ..
- GENETICS OF AUTOSOMAL DOMINANT POLYCYSTIC LIVER DISEASEStefan Somlo; Fiscal Year: 2010..At the same time, we will improve our understanding of ADPLD as a disease condition and develop insights that will help patients affected by this condition. ..
- High-Content Cell-Based Screening for Modulators of AutophagyXiao Ming Yin; Fiscal Year: 2007..Our long term hope is that the knowledge and the materials developed through this study will be valuable for future clinical applications. [unreadable] [unreadable] [unreadable]..
- Intercellular Signaling in Obstructive NephropathyROBERT CHEVALIER; Fiscal Year: 2005..This will lead to improved outcomes in adulthood. ..
- IMMUNOGENETICS OF TYPE 1 DIABETES IN A BEDOUIN FAMILYPamela Fain; Fiscal Year: 2003....
- Cux-1 and cell cycle regulation in kidney developmentGregory Vanden Heuvel; Fiscal Year: 2009..4. Define the relationship between Cux-1, TLE-4, and Notch signaling during podocyte development and nephrogenesis. These studies will provide novel insights into the mechanisms of cell proliferation during development. ..
- ICAM1 gene inactivation protects against ischemic injuryRobert Montgomery; Fiscal Year: 2006..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
- STEM CELL THERAPY IN ACUTE RENAL FAILUREFangming Lin; Fiscal Year: 2007....
- Role of airway submucosal glands in CF lung diseaseAlan S Verkman; Fiscal Year: 2010..The data will provide a rigorous scientific rationale for use of small-molecules in CF therapy, and establish widely useful assays to prioritize small molecules for clinical development. ..
- Opportunistic Oral HSV-- Mechanisms of ReactivationCraig Miller; Fiscal Year: 2006....
- PATHOPHYSIOLOGY OF THE AGING KIDNEYSharon Anderson; Fiscal Year: 2001..The use of a combined physiological, biochemical, immunohistochemical, and molecular biologic approach should gain insight into this clinically important but understudied problem. ..
- Gene transfer to the kidney using lentiviral vectorsFrank Park; Fiscal Year: 2004..abstract_text> ..
- APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICSAlan Verkman; Fiscal Year: 2001..These studies will address the hypothesis that the membrane skeleton of these cells is a mobile, dynamic structure. ..
- TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICEMartin Zand; Fiscal Year: 2002..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
- A NOVEL F BOX PROTEIN REGULATING MITOSISPeter Jackson; Fiscal Year: 2004..Understanding how SBP5 blocks mitosis and induces apoptosis may provide important insight for creating new cancer chemotherapeutic drugs that act similarly or synergistically with vinca alkaloids and Taxol. ..
- Towards renal regenerationMelissa Little; Fiscal Year: 2004..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..
- EPITHELIAL P2X PURINERGIC RECEPTOR CHANNELSErik Schwiebert; Fiscal Year: 2003..abstract_text> ..
- PHYSIOLOGY AND MOLECULAR BIOLOGY OF LUNG WATER TRANSPORTAlan Verkman; Fiscal Year: 2007..abstract_text> ..
- Centriole Orientation During Left/Right Symmetry Breaking in the MouseWallace Marshall; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Polycystin-1, ATP-induced Ca2+ entry & Cl - conductanceMichael Sutters; Fiscal Year: 2007..The long-term aim of his work is to facilitate the design of new therapeutic strategies to control disease progression through delineation of the mechanism of cyst expansion in ADPKD ..
- Small Molecule Inhibitors of CiliaWallace Marshall; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Multi-photon microscope for the Indiana Center for Biological MicroscopyKenneth Dunn; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICSAlan Verkman; Fiscal Year: 2006..abstract_text> ..
- Bc1-2 Family Proteins in the Ischemic Neuronal InjuryXiao Ming Yin; Fiscal Year: 2006..To characterize the molecular interactions of Bid and Bax in inducing dysfunction of mitochondria isolated from the brain. ..
- Genetic & Clinical Risk for Human SLE NephritisLee Hebert; Fiscal Year: 2007..Lay Summary: This research will lead to earlier diagnosis and treatment of kidney flares in lupus, and more effective use of available medications, resulting in improved clinical outcomes for SLE patients. ..
- Endocytic transport in cultured renal epitheliaKenneth Dunn; Fiscal Year: 2005..abstract_text> ..
- PATHOPHYSIOLOGY OF DIABETIC NEPHROPATHYSharon Anderson; Fiscal Year: 2007..abstract_text> ..