priapism

Summary

Summary: Persistent abnormal erection of the penis, usually without sexual desire, and accompanied by pain and tenderness. It is seen in diseases and injuries of the spinal cord, and may be caused by vesical calculus and certain injuries to the penis. (Dorland, 27th ed)

Top Publications

  1. doi Recurrent priapism related to oxaliplatin infusion
    Antoine Adenis
    J Clin Oncol 26:1016-7. 2008
  2. ncbi Priapism: pathogenesis, epidemiology, and management
    Gregory A Broderick
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    J Sex Med 7:476-500. 2010
  3. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
  4. ncbi Incidence of priapism in the general population
    I A Eland
    Pharmaco-epidemiology Unit, Departments of Internal Medicine and Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Urology 57:970-2. 2001
  5. pmc Refractory priapism associated with ingestion of yohimbe extract
    Amy Myers
    Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Med Toxicol 5:223-5. 2009
  6. ncbi Priapism associated with conventional and atypical antipsychotic medications: a review
    M T Compton
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    J Clin Psychiatry 62:362-6. 2001
  7. pmc Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 6:2494-504. 2009
  8. ncbi The actual incidence of papaverine-induced priapism in patients with erectile dysfunction following penile colour Doppler ultrasonography
    M Kilic
    Department of First Urology, Ataturk Teaching and Research Hospital, Bilkent, Ankara, Turkey
    Andrologia 42:1-4. 2010
  9. ncbi [Stuttering priapism in children with sickle cell anemia in Togo]
    A D Gbadoe
    Service de Pediatrie, hôpital CHU Tokoin, Universite de Lome, BP 8881, Lome, Togo
    Arch Pediatr 14:861-3. 2007
  10. ncbi Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:760-4. 2003

Detail Information

Publications280 found, 100 shown here

  1. doi Recurrent priapism related to oxaliplatin infusion
    Antoine Adenis
    J Clin Oncol 26:1016-7. 2008
  2. ncbi Priapism: pathogenesis, epidemiology, and management
    Gregory A Broderick
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    J Sex Med 7:476-500. 2010
    b>Priapism describes a persistent erection arising from dysfunction of mechanisms regulating penile tumescence, rigidity, and flaccidity...
  3. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..this simple biomarker was associated with a clinical subphenotype of pulmonary hypertension, leg ulceration, priapism, and risk of death in patients with sickle cell disease...
  4. ncbi Incidence of priapism in the general population
    I A Eland
    Pharmaco-epidemiology Unit, Departments of Internal Medicine and Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Urology 57:970-2. 2001
    OBJECTIVES: To assess the incidence of priapism in the general population. METHODS: We conducted a population-based retrospective cohort study within a general practitioners research database...
  5. pmc Refractory priapism associated with ingestion of yohimbe extract
    Amy Myers
    Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Med Toxicol 5:223-5. 2009
    ..In this report, we describe a severe case of intractable priapism associated with the ingestion of yohimbe extract...
  6. ncbi Priapism associated with conventional and atypical antipsychotic medications: a review
    M T Compton
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    J Clin Psychiatry 62:362-6. 2001
    BACKGROUND: Priapism is a prolonged, usually painful, and persistent penile erection not usually associated with sexual stimuli, resulting from a disturbance in the normal regulatory mechanisms that initiate and maintain penile flaccidity...
  7. pmc Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 6:2494-504. 2009
    b>Priapism is a poorly understood disease process with little information on the etiology and pathophysiology of this erectile disorder. One group of patients with a high prevalence of priapism is men with sickle-cell disease.
  8. ncbi The actual incidence of papaverine-induced priapism in patients with erectile dysfunction following penile colour Doppler ultrasonography
    M Kilic
    Department of First Urology, Ataturk Teaching and Research Hospital, Bilkent, Ankara, Turkey
    Andrologia 42:1-4. 2010
    ..concerns about the safety of this method due to the intracorporeal pharmacological injection, which may cause priapism as a complication, resulting in penile fibrosis...
  9. ncbi [Stuttering priapism in children with sickle cell anemia in Togo]
    A D Gbadoe
    Service de Pediatrie, hôpital CHU Tokoin, Universite de Lome, BP 8881, Lome, Togo
    Arch Pediatr 14:861-3. 2007
    To describe clinical aspects and outcome of stuttering priapism (SP) in children with sickle cell anemia.
  10. ncbi Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:760-4. 2003
    ..Effective therapy for ischemic priapism reestablishes corporal venous outflow and arterial inflow and results in increased corporal partial pressure of ..
  11. ncbi Testosterone replacement therapy does not promote priapism in hypogonadal men with sickle cell disease: 12-month safety report
    B F Morrison
    Department of Surgery, University of the West Indies, Mona, Jamaica
    Andrology 1:576-82. 2013
    ..The safety of testosterone replacement therapy (TRT) in SCD in relation to priapism episodes is relatively unknown...
  12. ncbi Pathophysiology of priapism: dysregulatory erection physiology thesis
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
    J Urol 170:26-34. 2003
    While a modest amount of medical literature has been written on the topic of priapism, reports heretofore have focused predominantly on diagnostic and management related aspects of the disorder, providing meager information in regard to ..
  13. ncbi Intracavernous papaverine/phentolamine-induced priapism can be accurately predicted with color Doppler ultrasonography
    Bahgat Metawea
    Andrology and Sexually Transmitted Diseases Department, Cairo University Hospital, Cairo, Egypt
    Urology 66:858-60. 2005
    To determine the value of penile duplex ultrasonography in predicting the occurrence of intracavernous drug-induced ischemic priapism directly after the rigid erection phase.
  14. ncbi Investigation of cavernosal smooth muscle dysfunction in low flow priapism using an in vitro model
    A Muneer
    The St Peter s Andrology Centre, University College London, London, UK
    Int J Impot Res 17:10-8. 2005
    ..acidosis and glucopenia, failure of conventional alpha-adrenergic agonists to produce tumescence in low flow priapism is associated with irreversible smooth muscle cell dysfunction, which is linked to ATP reduction and smooth ..
  15. pmc Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Sex Med 7:3011-22. 2010
    b>Priapism featured with painful prolonged penile erection is dangerous and commonly seen in sickle cell disease (SCD)...
  16. ncbi Priapism associated with olanzapine
    S H Hosseini
    Department of Psychiatry, Behavioral Science and Psychiatric Research Center, Zare Psychiatry Hospital, Mazandaran Medical Sciences University, K M5 Sari Neka High Way, Sari, Mazandaran, Post Cod 48171 19164, Iran
    Pak J Biol Sci 12:198-200. 2009
    b>Priapism is a rare but serious adverse effect of psychotropic drugs where antipsychotic agents were implicated in 15 to 26% of priapism associated with medications...
  17. ncbi The incidence of pharmacologically induced priapism in the diagnostic and therapeutic management of 685 men with erectile dysfunction
    P Perimenis
    Department of Urology, Medical School, University of Patras, Greece
    Urol Int 66:27-9. 2001
    OBJECTIVE: To evaluate the incidence of pharmacologically induced priapism in the diagnostic and therapeutic management of erectile dysfunction...
  18. ncbi Priapism
    Hossein Sadeghi-Nejad
    Division of Ultrasound, Department of Radiology, Case Western Reserve University, University Hospitals, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Radiol Clin North Am 42:427-43. 2004
    b>Priapism is a relatively uncommon condition that may present as a medical emergency associated with significant pain and anxiety in the veno-occlusive or low-flow variant...
  19. ncbi Structural analysis of the corpora cavernosa in patients with ischaemic priapism
    Waldemar S Costa
    State University of Rio de Janeiro, Rio de Janeiro, Brazil
    BJU Int 105:838-41; discussion 841. 2010
    ..Therapy (case series)...
  20. ncbi Testosterone replacement with 1% testosterone gel and priapism: no definite risk relationship
    Arthur L Burnett
    James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 2101, USA
    J Sex Med 10:1151-61. 2013
    ..Although testosterone replacement therapy (TRT) is the preferred treatment for hypogonadism, information for patients using testosterone includes too frequent or prolonged erections as a potential side effect...
  21. ncbi Priapism in sickle-cell disease; incidence, risk factors and complications - an international multicentre study
    A B Adeyoju
    Department of Urology, Royal Bolton Hospital, Bolton, UK
    BJU Int 90:898-902. 2002
    To define the incidence, risk factors and complications of priapism in a large population of patients with sickle-cell anaemia in five centres in the UK and Nigeria, as priapism is common among these patients, but the precise ..
  22. ncbi Priapism: new concepts in the pathophysiology and new treatment strategies
    Trinity J Bivalacqua
    Baltimore, MD 21287, USA
    Curr Urol Rep 7:497-502. 2006
    b>Priapism is defined as prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process, and we have little information on the etiology and pathophysiology of this erectile disorder...
  23. ncbi Stuttering priapism: insights into pathogenesis and management
    Belinda F Morrison
    Department of Surgery, University of the West Indies, Mona, Kingston 7, Jamaica
    Curr Urol Rep 13:268-76. 2012
    b>Priapism is defined as a persistent, painful erection that continues beyond, or is unrelated to, sexual stimulation. It may be categorized as either ischemic (low/absent flow) or nonischemic (high flow)...
  24. ncbi In vitro and in vivo animal models in priapism research
    Qiang Dong
    Department of Urology, West China Hospital, Sichuan University, Chengdu, China
    J Sex Med 8:347-59. 2011
    b>Priapism is an enigmatic yet devastating clinical phenomenon. In the last two decades, the use of various animal models to study this disorder has dramatically advanced our understanding of this mysterious disorder.
  25. ncbi Priapism from quetiapine overdose: first report and proposal of mechanism
    V M Pais
    Division of Urology, Department of Surgery, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Urology 58:462. 2001
    We report a case of priapism occurring after an overdose of the newly approved atypical antipsychotic quetiapine...
  26. ncbi Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues
    Yong Chun Jin
    Department of Pharmacology, School of Medicine, Gyeongsang National University Hospital, 90 Chilamdong, Jinju 660 702, South Korea
    J Sex Med 5:1876-82. 2008
    ..The inducible isoform of heme oxygenase (HO)-1 regulates the vascular smooth muscle tone and responds to hypoxia...
  27. ncbi Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case
    David S Finley
    UC Irvine Department of Urology, Orange, CA 92868, USA
    J Sex Med 5:2963-6. 2008
    Stuttering priapism is an uncommon form of recurrent priapism whose etiology if often unknown. To date, there has been one report of a patient with stuttering priapism and glucose-6-phosphate dehydrogenase (G6PD) deficiency...
  28. ncbi TGF-beta1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism
    O Sanli
    Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Int J Impot Res 16:492-7. 2004
    ..role of transforming growth factor beta 1 (TGF-beta1) antibodies (ab) for the prevention of fibrotic effects of priapism in a rat model. In total, 30 adult Sprague-Dawley rats were divided into five groups...
  29. ncbi Cocaine and ephedrine-induced priapism: case reports and investigation of potential adrenergic mechanisms
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:187-92. 2003
    ..We also provide three case reports of patients who developed priapism secondary to using either cocaine or nonprescription weight loss formulations containing ephedrine...
  30. ncbi Priapism and sickle-cell anemia: diagnosis and nonsurgical therapy
    Gregory A Broderick
    Department of Urology, Mayo Clinic, FL 32224, USA
    J Sex Med 9:88-103. 2012
    b>Priapism describes a persistent erection lasting longer than 4 hours. Ischemic priapism and stuttering priapism are phenotypic manifestations of sickle-cell disease (SCD).
  31. ncbi Recurrent priapism during treatment with clozapine, quetiapine and haloperidol
    Hygiea Casiano
    J Psychopharmacol 21:898-9. 2007
    The following is a letter to the editor that represents a case of recurrent priapism. The patient received clozapine, quetiapine and haloperidol and had the adverse reaction of priapism, one episode of which required surgical intervention...
  32. ncbi An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis
    Nihat Uluocak
    Department of Urology, Gaziosmanpasa University, Tokat, Turkey
    Int Urol Nephrol 42:889-95. 2010
    ..study was designed to produce ischemia-reperfusion (I/R) injury in rat corpus cavernosum by inducing 1 h of priapism and investigating the effects of melatonin on the levels of oxidative injury parameters...
  33. ncbi Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism?
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Sex Med 5:237-40. 2008
    Efforts to identify the health risk associations for priapism may reveal pathophysiologic mechanisms for the disorder and suggest a scientifically rational approach for correcting it.
  34. pmc Medical management of ischemic stuttering priapism: a contemporary review of the literature
    Helen R Levey
    The Arthur Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, NY 11010, USA
    Asian J Androl 14:156-63. 2012
    b>Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder...
  35. ncbi Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity
    Frank Andersohn
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    J Clin Psychopharmacol 30:68-71. 2010
    Case reports indicate that antipsychotics can cause priapism, a persistent penile erection possibly leading to erectile dysfunction...
  36. ncbi Report of the American Foundation for Urologic Disease (AFUD) Thought Leader Panel for evaluation and treatment of priapism
    R Berger
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 13:S39-43. 2001
    PURPOSE: Patients with priapism often develop permanent erectile dysfunction and personal sexual distress...
  37. ncbi Priapism
    Regina M du Toit
    Can J Psychiatry 49:868-9. 2004
  38. ncbi 38-year-old man with priapism and a history of paranoid schizophrenia
    Axel Pflueger
    Mayo Graduate School of Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:111-4. 2005
  39. ncbi A prospective diary study of stuttering priapism in adolescents and young men with sickle cell anemia: report of an international randomized control trial--the priapism in sickle cell study
    Ade B Olujohungbe
    University Hospital Aintree, National Health Service Foundation Trust, Liverpool, United Kingdom
    J Androl 32:375-82. 2011
    b>Priapism is defined as a prolonged, persistent, and purposeless penile erection. It is a common (35%) but frequently understated complication in young men and adults with sickle cell disease...
  40. ncbi Materials in embolotherapy of high-flow priapism: results and long-term follow-up
    Mehmet Halil Oztürk
    Department of Radiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey
    Diagn Interv Radiol 15:215-20. 2009
    To review our experience with embolic materials used in the selective arterial embolization of high-flow priapism and present the results of long-term follow-up.
  41. ncbi New insights into the pathophysiology of sickle cell disease-associated priapism
    Trinity J Bivalacqua
    Department of Urology, Johns Hopkins Medical Institutions, The James Buchanan Brady Urological Institute, Marburg, Baltimore, MD 21287, USA
    J Sex Med 9:79-87. 2012
    b>Priapism is defined as an erectile disorder, in which erection persists uncontrollably without sexual purpose. The precise mechanisms involved in the development of sickle cell disease-associated priapism are ill defined.
  42. ncbi Priapism associated with routine use of quetiapine: case report and review of the literature
    Patrick Davol
    Division of Urology, Department of Surgery, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Urology 66:880. 2005
    We report a case of priapism occurring in a patient taking a standard daily dose of the atypical antipsychotic quetiapine (Seroquel)...
  43. pmc Evaluation and management of priapism: 2009 update
    Yun Ching Huang
    Department of Urology, University of California, San Francisco, CA 94143, USA
    Nat Rev Urol 6:262-71. 2009
    b>Priapism is defined as a persistent penile erection (typically 4 h or longer) that is unrelated to sexual stimulation. Priapism can be classified as either ischemic or nonischemic...
  44. ncbi Corporal "snake" maneuver: corporoglanular shunt surgical modification for ischemic priapism
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
    J Sex Med 6:1171-6. 2009
    Current surgical shunting procedures for major ischemic priapism do not always effectively resolve acute presentations of this disorder.
  45. ncbi Novel technique in the management of low flow priapism
    Steve Y Chung
    Department of Urology, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Urol 170:1952. 2003
  46. ncbi Priapism associated with trazodone in an adolescent with autism
    Deborah L Kem
    J Am Acad Child Adolesc Psychiatry 41:758. 2002
  47. ncbi Follow-up of sickle cell disease patients with priapism treated by hydroxyurea
    Sara T O Saad
    Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sao Paulo, Brazil
    Am J Hematol 77:45-9. 2004
    ..b>Priapism is one of the complications that could be prevented by hydroxyurea, but there are few reports demonstrating the ..
  48. pmc Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue
    N D Kanika
    Department of Urology, Institute of Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Impot Res 22:363-73. 2010
    b>Priapism is a debilitating disease for which there is at present no clinically accepted pharmacological intervention. It has been estimated that priapism lasting more than 24 h in patients is associated with a 44-90% rate of ED...
  49. ncbi Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    Arthur L Burnett
    Johns Hopkins University Urology, Baltimore, MD, USA
    J Sex Med 3:1077-84. 2006
    Recurrent ischemic priapism is an enigmatic erectile disorder in need of improved clinical interventions to avert its known, potentially serious complications.
  50. ncbi Distal cavernosum-glans shunts for ischemic priapism
    Tom F Lue
    Department of Urology, University of California, San Francisco, CA, USA
    J Sex Med 3:749-52. 2006
  51. ncbi T-shaped shunt and intracavernous tunneling for prolonged ischemic priapism
    William O Brant
    Northstar Urology, Vail, Colorado
    J Urol 181:1699-705. 2009
    Conservative management of prolonged ischemic priapism is rarely effective. Interventions include corporal aspiration/irrigation, injection of vasoconstrictive agents or surgical procedures...
  52. ncbi Priapism associated with the switch from oral to injectable risperidone
    Alla Kirshner
    Department of Psychiatry, University of Manitoba, Canada
    J Clin Psychopharmacol 26:626-8. 2006
    b>Priapism is a rare, but serious, side effect of psychotropic medications. Psychotropic medication-induced priapism is believed to be caused by the alpha-adrenergic antagonism of these medications...
  53. ncbi Priapism and quetiapine in an HIV-positive male
    George Harrison
    J Clin Psychopharmacol 26:100-1. 2006
  54. ncbi Changing diagnostic and therapeutic concepts in high-flow priapism
    R Kuefer
    Department of Urology, Faculty of Medicine, University of Ulm, Ulm, Germany
    Int J Impot Res 17:109-13. 2005
    High-flow priapism (HFP) is defined as pathological increased arterial influx into the cavernosal bodies. Since 1960, 202 cases have been published in the literature...
  55. ncbi Management of ischemic priapism with high-dose intracavernosal phenylephrine: from bench to bedside
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 3:918-22. 2006
    Ischemic priapism is associated with cavernosal acidosis, which decreases the efficacy of adrenergic agonists...
  56. ncbi Sickle cell disease status and outcomes of African-American men presenting with priapism
    Nelson Bennett
    Memorial Sloan Kettering Cancer Center Urology, New York, NY, USA
    J Sex Med 5:1244-50. 2008
    b>Priapism is associated with sickle cell disease (SSD); however, few men receive education about this condition, which contributes to attenuated return of functional erections.
  57. ncbi Treatment of recurrent priapism in sickle cell anemia with finasteride: a new approach
    Daibes Rachid-Filho
    Souza Aguiar Municipal Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Urology 74:1054-7. 2009
    To determine whether the use of finasteride controls recurrent priapism in patients with sickle cell anemia.
  58. ncbi [Embolization of the bilateral internal pudendal arteries for intractable priapism in a child with chronic myelogenous leukemia]
    K Murayama
    Department of Pediatrics, Saitama Medical School
    Rinsho Ketsueki 42:1117-21. 2001
    b>Priapism is an uncommon clinical symptom in children with chronic myelogenous leukemia (CML). Here we report a 14-year-old boy with this symptom, which had appeared 4 days prior to hospitalization...
  59. pmc The mechanism of opiorphin-induced experimental priapism in rats involves activation of the polyamine synthetic pathway
    Nirmala Devi Kanika
    Department of Urology and Institute of Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Cell Physiol 297:C916-27. 2009
    ..when added to the drinking water of animals treated with plasmids expressing opiorphins, prevented experimental priapism. We also demonstrate that in sickle cell mice, another model of priapism, there is increased expression of the ..
  60. pmc Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
    Hunter C Champion
    Department of Cardiology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:1661-6. 2005
    The molecular mechanism for priapism is not well characterized...
  61. ncbi The aetiology, pathogenesis and management of priapism
    S R Keoghane
    Department of Urology, Northampton General Hospital, Cliftonville, UK
    BJU Int 90:149-54. 2002
  62. ncbi Priapism associated with atypical antipsychotic medications: a review
    Shabnam Sood
    Department of Psychiatry, Maricopa Integrated Health System, Mesa, Arizona, USA
    Int Clin Psychopharmacol 23:9-17. 2008
    b>Priapism defined as persistent, painful and prolonged penile erection, was previously thought to be associated only with the use of the older, conventional first generation or typical antipsychotic medications as well as some other ..
  63. ncbi Increased cavernosal relaxations in sickle cell mice priapism are associated with alterations in the NO-cGMP signaling pathway
    Mário Angelo Claudino
    Department of Pharmacology, Faculty of Medical Sciences University of Campinas, Campinas, Sao Paulo, Brazil
    J Sex Med 6:2187-96. 2009
    b>Priapism is defined as prolonged and persistent penile erection, unassociated with sexual interest or stimulation, and is one of the many serious complications associated with sickle cell disease (SCD).
  64. pmc Priapism in sickle-cell disease: a hematologist's perspective
    Gregory J Kato
    National Heart, Lung and Blood Institute, National Institutes of Health Sickle Cell Vascular Disease Section, Cardiovascular and Pulmonary Branch, Bethesda, MD 20892 1476, USA
    J Sex Med 9:70-8. 2012
    b>Priapism is a familiar problem to hematologists, well known for its association with sickle-cell disease (SCD)...
  65. ncbi Priapism
    John Pryor
    Institute of Urology, London University, London, UK
    J Sex Med 1:116-20. 2004
    There are three different types of priapism: low-flow, ischemic, anoxic or veno-occlusive priapism; high-flow, arterial or nonischemic priapism; and recurrent or stuttering priapism.
  66. pmc Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin St, MSB 6 200, Houston, TX 77030, USA
    FASEB J 24:740-9. 2010
    b>Priapism is a condition of persistent penile erection in the absence of sexual excitation. Of men with sickle cell disease (SCD), 40% display priapism...
  67. ncbi Priapism in southwestern Nigeria
    T A Badmus
    Department of Surgery, Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
    East Afr Med J 80:518-24. 2003
    To determine the aetiology, pattern of presentation, treatment regimen and outcome of management of priapism in our environment and to compare our findings with previous studies in this country and elsewhere.
  68. ncbi Etilefrine for the prevention of priapism in adult sickle cell disease
    Iheanyi Okpala
    Department of Haematology, St Thomas Hospital, London, UK
    Br J Haematol 118:918-21. 2002
    b>Priapism is a common complication of sickle cell disease (SCD) that could lead to erectile dysfunction and psychosocial problems. Treatment of established fulminant priapism is usually not satisfactory...
  69. ncbi The incidence and management of priapism in Western Australia: a 16 year audit
    C M Earle
    Keogh Institute for Medical Research, QEII Medical Centre, Nedlands, Western Australia, Australia
    Int J Impot Res 15:272-6. 2003
    The objective of the study was to conduct a retrospective audit of patients who presented with priapism in Western Australia during the years 1985-2000...
  70. ncbi Priapism secondary to hypertriglyceridemia
    Robert E Gerstenbluth
    Department of Urology, University Hospitals of Cleveland, Case Western Reserve University, Ohio, USA
    J Urol 169:1088. 2003
  71. ncbi Priapism and penile gangrene due to thrombotic thrombocytopenic purpura
    Benjamin Kwok
    Nepean Private Hospital, Kingswood NSW
    Urology 75:71-2. 2010
    A 51-year-old man presented with 4 days of idiopathic ischemic priapism. Partial detumescence was achieved with aspiration and injection with intracorporeal adrenaline...
  72. ncbi Management of ischemic priapism by penile prosthesis insertion: prevention of distal erosion
    Emad A Salem
    Urology and Dermatology OEA Departments, Zagazig University, Zagazig, Egypt
    J Urol 183:2300-3. 2010
    Refractory ischemic priapism results in cavernous smooth muscle necrosis, fibrosis and eventual penile shortening...
  73. ncbi Preventive treatment of priapism in sickle cell disease with oral and self-administered intracavernous injection of etilefrine
    R Virag
    Centre d Explorations et de Traitements de l Impuissance, Paris, France
    Urology 47:777-81; discussion 781. 1996
    b>Priapism is a common and currently unsatisfactorily managed complication of sickle cell disease (SCD). In June 1994, 6 SCD patients received a new therapeutic regimen to prevent the occurrence and recurrence of priapism.
  74. ncbi Priapism associated with hemoglobin C trait
    Brent R Gibson
    Department of Surgery, Urology Service, Madigan Army Medical Center, Tacoma, Washington, USA
    J Urol 168:2122. 2002
  75. ncbi Low-flow priapism: risk factors for erectile dysfunction
    M S El-Bahnasawy
    Department of Urology, Mansoura Urology and Nephrology Center, Mansoura, Egypt
    BJU Int 89:285-90. 2002
    To evaluate our policy of managing priapism for the success rate of the treatments, potency afterward, complications, and the risk factors responsible for erectile dysfunction in these patients.
  76. pmc The opiorphin gene (ProL1) and its homologues function in erectile physiology
    Yuehong Tong
    Department of Urology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    BJU Int 102:736-40. 2008
    ....
  77. ncbi Tricorporal priapism in a patient with metastatic esophageal cancer
    Carlos R Estrada
    Department of Urology, Rush Medical College, Chicago, Illinois, USA
    Urology 61:1259. 2003
    Tricorporal priapism refers to priapism involving the corpora cavernosa and spongiosum. It is exceedingly rare and, depending on the etiology, may be difficult or impossible to treat...
  78. ncbi Insights of priapism mechanism and rationale treatment for recurrent priapism
    Jiuhong Yuan
    Department of Urology, University of Texas Health Science Center, Houston, TX 77030, USA
    Asian J Androl 10:88-101. 2008
    b>Priapism is defined as abnormal prolonged penile erection occurring beyond or unrelated to sexual interest...
  79. ncbi Propofol-induced priapism, a case confirmed with rechallenge
    Kimi S Vesta
    Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73190 5040, USA
    Ann Pharmacother 40:980-2. 2006
    To report a case of propofol-induced priapism.
  80. ncbi Priapism: current principles and practice
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Instituitions, Baltimore, MD, USA
    Urol Clin North Am 34:631-42, viii. 2007
    b>Priapism, a pathologic condition of persistent penile erection in the absence of sexual excitation, is a true erectile disorder. Although it may seem to affect only a small population of male individuals, it carries major significance...
  81. ncbi Intermittent priapism in degenerative lumbar spinal stenosis: case report
    Tufan Cansever
    Istanbul University, Neurosurgery Department, Istanbul, Turkey
    Turk Neurosurg 17:260-3. 2007
    ..One of the uncommon symptoms is involuntary intermittent penile erection due to spinal canal stenosis. This symptom is very rare and often forgotten when history is taken...
  82. ncbi Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency
    R A H Abu Sham'a
    Department of Internal Medicine and Cardiology, Makassed Hospital, Jerusalem, Israel
    Int J Lab Hematol 30:339-43. 2008
    b>Priapism is a rare disorder defined as a persistent penile erection that continues hours beyond, or is unrelated to, sexual stimulation...
  83. ncbi Successful treatment of propofol-induced priapism with distal glans to corporal cavernosal shunt
    Ennio J Fuentes
    Department of Pediatric Surgery, Complejo Hospitalario de Ourense, Orense, Spain
    Urology 74:113-5. 2009
    We report a case of postoperative pediatric priapism in a boy without a hematologic disorder after a propofol-based general anesthetic...
  84. ncbi The investigation of putative agents, using an in vitro model, to prevent cavernosal smooth muscle dysfunction during low-flow priapism
    Asif Muneer
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    BJU Int 102:988-92. 2008
    ..of putative agents for preventing irreversible smooth muscle dysfunction, using an in vitro model of low-flow priapism (a condition conventionally managed using a combination of corporal blood aspiration and instillation of alpha-..
  85. ncbi Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 67:1043-8. 2006
    Recurrent ischemic priapism describes a disorder of repeated episodes of prolonged penile erection that frequently leads to devastating complications of erectile tissue damage and erectile dysfunction...
  86. ncbi Conservative management of priapism in acute spinal cord injury
    S Alexis Gordon
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Texas 75390 9110, USA
    Urology 65:1195-7. 2005
    To perform a retrospective chart review of priapism as a complication of spinal cord injury and review the management and follow-up...
  87. pmc Hemolysis-associated priapism in sickle cell disease
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, MA, USA
    Blood 106:3264-7. 2005
    b>Priapism, although uncommon in the general population, is one of the many serious complications associated with sickle cell disease (SCD)...
  88. ncbi Tadalafil-associated priapism
    Stephen H King
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    Urology 66:432. 2005
    ..He had no other identified contributing factors for priapism. After confirmation of ischemic priapism and failure of bedside management in the Emergency Department, the ..
  89. ncbi Hematological parameters in sickle cell anemia patients with and without priapism
    Sagir G Ahmed
    Department of Haematology, College of Medical Sciences, Universtiy of Maiduguri, Borneo State, Nigeria
    Ann Saudi Med 26:439-43. 2006
    b>Priapism was associated with certain hematological parameters in sickle cell anemia (SCA) patients in one report but not in another. We studied differences in haematological parameters between SCA patients with and without priapism.
  90. ncbi Priapism in sickle cell disease
    Zora R Rogers
    Division of Pediatric Hematology Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Hematol Oncol Clin North Am 19:917-28, viii. 2005
    b>Priapism, an unwanted painful erection of the penis, is a little discussed but common complication of sickle cell disease...
  91. ncbi Genetic polymorphisms associated with priapism in sickle cell disease
    Laine Elliott
    Department of Medicine, Duke University and VA Medical Centers, Durham, NC 27710, USA
    Br J Haematol 137:262-7. 2007
    b>Priapism occurs in 30-45% of male patients with sickle cell disease (SCD), but the possible influence of genetic risk factors on the incidence of priapism is not well understood...
  92. pmc Medical and surgical management of priapism
    J Cherian
    Department of Urology, Bradford Royal Infirmary, Bradford, UK
    Postgrad Med J 82:89-94. 2006
    b>Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation...
  93. ncbi Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol
    Michael McDonald
    Division of Urology, Wayne State University, Detroit, Michigan 48201, USA
    Int Braz J Urol 30:121-2. 2004
    Low-flow priapism can result in impotence if treatment is delayed, yet patients with recurrent priapism often suffer delay before therapy...
  94. ncbi Posttraumatic nonischemic priapism treated with autologous blood clot embolization
    Furuzan Numan
    Department of Radiology, Division of Interventional Radiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Sex Med 5:173-9. 2008
    High-flow arterial priapism is rare and characterized by a prolonged nonpainful erection. Autologous clot embolization allows complete resolution of the problem in most of the cases.
  95. ncbi [A report of two cases of priapism with metastatic penile tumor]
    Takayuki Hattori
    Department of Urology, Chubu Rosai Hospital, Nagoya, Japan
    Nihon Hinyokika Gakkai Zasshi 93:568-72. 2002
    We report two cases of priapism with metastases to the penis. The first case was a 52-year old man, diagnosed as suffering from gastric cancer by endoscopic biopsy five years previously, but for whom no treatment was performed...
  96. ncbi [Pediatric priapism associated with pulmonary infection]
    H Sibai
    Service de Chirurgie Viscerale Pediatrique, Hôpital d Enfants, CH Ibn Rochd, Casablanca, Maroc
    Ann Urol (Paris) 37:143-5. 2003
    b>Priapism is a rare urologic emergency in pediatric population. It is usually a consequence of sickle cell disease. Leukemia is another important cause of priapism in children...
  97. ncbi Fabry disease and G6PD in three family members with priapism: is the nitric oxide pathway to blame?
    Rebecca Backenroth
    Department of Nephrology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Sex Med 7:1588-91. 2010
    ....
  98. ncbi American Urological Association guideline on the management of priapism
    Drogo K Montague
    J Urol 170:1318-24. 2003
  99. ncbi Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism
    Guiting Lin
    Department of Urology, Knuppe Molecular Urology Laboratory, University of California School of Medicine, San Francisco, CA 94143 1695, USA
    J Urol 170:S15-8; discussion S19. 2003
    We identify whether tachyphylaxis and priapism effects of sildenafil are related to regulation of phosphodiesterase-5 (PDE-5) expression.
  100. ncbi Sildenafil relieves priapism in patients with sickle cell disease
    Eldad S Bialecki
    Am J Med 113:252. 2002
  101. ncbi Malignant priapism secondary to bladder cancer
    Sezgin Guvel
    Departments of Urology and Nephrology, Baskent University Medical School, Adana Clinic and Research Center, Adana, Turkey
    J Androl 24:499-500. 2003

Research Grants20

  1. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..Foundation to study the pathophysiology of endothelial cell dysfunction in sickle cell disease-associated priapism. During my residency and post-doctoral fellowship, I gained invaluable experience in both clinical and basic ..
  2. The Role of Vsca1 in Erectile Function
    Kelvin P Davies; Fiscal Year: 2010
    ..of plasmids expressing Vcsal increased erectile function in ageing rats and higher amounts of plasmid caused priapism, suggesting a direct role of the Vcsal gene in erectile physiology...
  3. Involvement of opiorphins and polyamine synthesis in the development of priapism
    Kelvin P Davies; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Priapism is a disease which affects several thousand men in the US and millions worldwide, for which there is no pharmacological treatment...
  4. Adenosine Signaling, Priapism and Sickle Cell Disease
    Yang Xia; Fiscal Year: 2012
    PROJECT SUMMARY/ABSTRACT Priapism is defined as prolonged penile erection occurring unassociated with sexual interest. 40% of male sickle cell disease (SCD) patients display priapism...
  5. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2010
    ..disease (SCD) is characterized by acute clinical manifestations, including painful crisis, acute chest syndrome, priapism, and stroke, as well as chronic irreversible damage to the heart, lungs, kidneys, eyes, spleen and femoral heads...
  6. Androgen Regulation of Priapism in Sickle Cell Disease
    Arthur Louis Burnett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Priapism is a disorder of non-willful, excessive penile erection recurrences affecting diverse populations...
  7. NOS Regulation in the Penis
    Arthur Louis Burnett; Fiscal Year: 2013
    ..by applicant): Disorders of penile erection, which includes male erectile dysfunction, recurrent ischemic priapism and penile fibrosis, remain vexatious clinical management conditions and are addressed with limited effective ..
  8. EFFECT OF CASTRATION+/-ESTROGEN ON THE CORPUS CAVERNOSUM
    Gregory Broderick; Fiscal Year: 1993
    ..A second important clinical problem involves priapism (prolonged erection)...
  9. 2008 AUA/SBUR Summer Research Conference
    Arthur Burnett; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....
  11. Actions of Immunophilins in Penile Nerve Function
    Arthur Burnett; Fiscal Year: 2007
    ..The experimental work described herein combines molecular biologic, erection physiologic, and morphologic studies. ..
  12. Genome-Wide Association Studies in Sickle Cell Anemia and in Centenarians
    Martin H Steinberg; Fiscal Year: 2010
    ..compare associations with clinical features of HbSS including blood pressure, survival, stroke, osteonecrosis, priapism, leg ulcers and an integrated measure of disease severity and also selected laboratory measurements including ..
  13. Genetic Modulation of Sickle Cell Disease
    Martin H Steinberg; Fiscal Year: 2010
    ....
  14. Determinants of HbF Response to Hydroxyurea
    Martin Steinberg; Fiscal Year: 2005
    ..5 cM resolution. We hope ultimately to discover SNPs, haplotypes or genes that predict or modulate the HbF response to hydroxyurea and better define HbF regulation in sickle cell anemia. ..
  15. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..
  16. REGULATION OF THE ERYTHROPOIETIN GENE
    H Bunn; Fiscal Year: 2003
    ..These studies should provide unique and highly relevant information about common mechanisms of oxygen sensing, signal transduction and gene regulation that enable organisms to adapt to hypoxia. ..
  17. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2005
    ..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
  18. OXYGEN SENSING AND SIGNAL TRANSDUCTION
    H Bunn; Fiscal Year: 2003
    ..abstract_text> ..
  19. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  20. eNOS-Protein Interaction in the Penis
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time, it may suggest a specific eNOS regulatory pathway as a possible new molecular target for treating ED. [unreadable] [unreadable] [unreadable]..