hypospadias

Summary

Summary: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.

Top Publications

  1. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
  2. ncbi Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Birth Defects Res A Clin Mol Teratol 88:910-9. 2010
  3. ncbi Maternal reproductive and demographic characteristics as risk factors for hypospadias
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Paediatr Perinat Epidemiol 21:210-8. 2007
  4. ncbi Evidence for epigenetic abnormalities of the androgen receptor gene in foreskin from children with hypospadias
    A Vottero
    Department of Pediatrics, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    J Clin Endocrinol Metab 96:E1953-62. 2011
  5. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
  6. ncbi Genital anomalies in boys and the environment
    Katharina M Main
    University Department of Growth and Reproduction GR, Section 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 24:279-89. 2010
  7. ncbi Hypospadias in males with intrauterine growth restriction due to placental insufficiency: the placental role in the embryogenesis of male external genitalia
    Yoav Yinon
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Placenta Clinic, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 152:75-83. 2010
  8. ncbi Urethral seam formation and hypospadias
    L S Baskin
    Department of Urology, University of California School of Medicine, San Francisco, CA 94143 0738, USA
    Cell Tissue Res 305:379-87. 2001
  9. ncbi The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case-control study in rural Sicily
    P Carbone
    Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
    Int J Androl 30:3-13. 2007
  10. ncbi Complex segregation analysis of hypospadias
    Louise Fredell
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital CMM 02, SE 171 76 Stockholm, Sweden
    Hum Genet 111:231-4. 2002

Detail Information

Publications265 found, 100 shown here

  1. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear...
  2. ncbi Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Birth Defects Res A Clin Mol Teratol 88:910-9. 2010
    Cryptorchidism and hypospadias are common genital birth defects that affect 2-9% and 0.2-1% of male newborns, respectively...
  3. ncbi Maternal reproductive and demographic characteristics as risk factors for hypospadias
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Paediatr Perinat Epidemiol 21:210-8. 2007
    This study examined the association of hypospadias risk with several maternal reproductive and demographic characteristics: age, parity, body mass index (BMI), nausea and vomiting of pregnancy (NVP), multiple pregnancy, fertility ..
  4. ncbi Evidence for epigenetic abnormalities of the androgen receptor gene in foreskin from children with hypospadias
    A Vottero
    Department of Pediatrics, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    J Clin Endocrinol Metab 96:E1953-62. 2011
    b>Hypospadias is a malformation of the penis due to an incomplete development of the male urethra, the exact etiology of which in the majority of cases remains unknown.
  5. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
    ..low and probably declining semen quality; high and possibly increasing frequencies of undescended testis and hypospadias; and an apparently growing demand for assisted reproduction...
  6. ncbi Genital anomalies in boys and the environment
    Katharina M Main
    University Department of Growth and Reproduction GR, Section 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 24:279-89. 2010
    ..These disorders are aetiologically linked with congenital cryptorchidism and hypospadias by common factors leading to perinatal disruption of normal testis differentiation, the testicular dysgenesis ..
  7. ncbi Hypospadias in males with intrauterine growth restriction due to placental insufficiency: the placental role in the embryogenesis of male external genitalia
    Yoav Yinon
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Placenta Clinic, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 152:75-83. 2010
    ..the association between early onset intra-uterine growth restriction (IUGR) due to placental insufficiency and hypospadias in males...
  8. ncbi Urethral seam formation and hypospadias
    L S Baskin
    Department of Urology, University of California School of Medicine, San Francisco, CA 94143 0738, USA
    Cell Tissue Res 305:379-87. 2001
    Knowledge of the formation of the normal male urethra may elucidate the etiology of hypospadias. We describe urethral formation in the mouse, show the similarities and relevance to human urethral development, and introduce the concept of ..
  9. ncbi The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case-control study in rural Sicily
    P Carbone
    Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
    Int J Androl 30:3-13. 2007
    ..exposures to potential endocrine disrupting chemicals (EDC) assessed by questionnaire and cryptorchidism and hypospadias in their offspring in the agricultural area of Ragusa...
  10. ncbi Complex segregation analysis of hypospadias
    Louise Fredell
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital CMM 02, SE 171 76 Stockholm, Sweden
    Hum Genet 111:231-4. 2002
    b>Hypospadias, when the urethra opens on the ventral side of the penis, is a common malformation seen in about 3 per 1000 male births...
  11. pmc Maternal corticosteroid use and hypospadias
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, CA 94609, USA
    J Pediatr 155:39-44, 44.e1. 2009
    To explore whether women who reported corticosteroid use during pregnancy were more likely to deliver an infant with hypospadias than women who did not.
  12. pmc Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients
    Xian Yang Qin
    Health Risk Research Section, Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    PLoS ONE 7:e36711. 2012
    ..basis of the effect of BPA on human reproductive health, a genome-wide screen was performed using human foreskin fibroblast cells (hFFCs) derived from child hypospadias (HS) patients to identify novel targets of low-dose BPA exposure.
  13. ncbi Comparative analysis of tubularized incised plate versus onlay island flap urethroplasty for penoscrotal hypospadias
    Luis H P Braga
    Division of Urology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Urol 178:1451-6; discussion 1456-7. 2007
    Despite being the dominant technique for repair of distal hypospadias, application of the tubularized incised plate approach for penoscrotal hypospadias remains controversial...
  14. ncbi Rising hypospadias rates: disproving a myth
    Harry Fisch
    Columbia University College of P and S, The Department of Urology, 219N, New York, NY 10463, USA
    J Pediatr Urol 6:37-9. 2010
    b>Hypospadias is one of the most common congenital abnormalities occurring in males...
  15. ncbi Maternal diet and the risk of hypospadias and cryptorchidism in the offspring
    Felice Giordano
    Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
    Paediatr Perinat Epidemiol 22:249-60. 2008
    ..The purpose of this study was to explore the association between hypospadias and cryptorchidism, and the dietary habits of an agricultural population in Italy...
  16. pmc Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    Environ Health Perspect 117:1472-6. 2009
    The etiologies of the male urogenital anomalies cryptorchidism and hypospadias are poorly understood. It has been suggested, however, that in utero hormone levels may be related to risk...
  17. ncbi Correction of hypospadias with a vertical preputial island flap: a 23-year experience
    Nicolo Scuderi
    Department of Plastic and Reconstructive Surgery, University of Rome La Sapienza, Rome, Italy
    J Urol 175:1083-7; discussion 1087. 2006
    We report our experience using the preputial island flap technique (Scuderi procedure) to correct penile hypospadias.
  18. ncbi Molecular epidemiology of hypospadias: review of genetic and environmental risk factors
    Jeanne M Manson
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Birth Defects Res A Clin Mol Teratol 67:825-36. 2003
    b>Hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 125 live male births. It is characterized by altered development of the urethra, foreskin, and ventral surface of the penis...
  19. ncbi Polymorphisms of MAMLD1 gene in hypospadias
    N Kalfa
    Service d Hormonologie, Hopital Lapeyronie, CHU de Montpellier et UM1, Montpellier, France
    J Pediatr Urol 7:585-91. 2011
    ..Almost 10% of patients with both severe and non-severe hypospadias exhibit mutations of MAMLD1...
  20. ncbi Common variants in DGKK are strongly associated with risk of hypospadias
    Loes F M van der Zanden
    Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Genet 43:48-50. 2011
    b>Hypospadias is a common congenital malformation of the male external genitalia...
  21. ncbi Endocrine disruptors, genital development, and hypospadias
    Ming Hsien Wang
    UCSF Children s Hospital, Department of Urology, University of California, San Francisco, 400 Parnassus Avenue A640, San Francisco, CA 94143, USA
    J Androl 29:499-505. 2008
    b>Hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 125 live male births...
  22. ncbi Mutation analysis of five candidate genes in Chinese patients with hypospadias
    Yanping Wang
    Institute of Basic Medical Sciences, PUMC and CAMS, Beijing, 100005, China
    Eur J Hum Genet 12:706-12. 2004
    b>Hypospadias is the displacement of the urethral meatus from the tip of the glans to the ventral side of the phallus...
  23. ncbi Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias
    Xian Yang Qin
    Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Hum Genet 57:434-41. 2012
    ..RXRB, RXRG, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP3A4, CYP17A1 and CYP19A1) and risk of cryptorchidism (CO) and hypospadias (HS) in 334 Japanese (JPN) males (141 controls, 95 CO and 98 HS) and 187 Italian (ITA) males (129 controls and ..
  24. ncbi Screening for mutations in candidate genes for hypospadias
    A Nordenskjold
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Urol Res 27:49-55. 1999
    b>Hypospadias. a condition with a frontally placed urethral orifice on the penis, is the most common malformation in males. During fetal development several components are necessary for normal male genital development...
  25. ncbi Algorithm for comprehensive approach to hypospadias reoperation using 3 techniques
    Warren T Snodgrass
    Pediatric Urology Section, Children s Medical Center, Dallas, Texas 75207, USA
    J Urol 182:2885-91. 2009
    We describe comprehensive hypospadias reoperation based on presence or absence of a supple urethral plate using the 3 surgical techniques of transurethral incised plate, 1-stage inlay graft and 2-stage buccal graft.
  26. ncbi Hypospadias and the androgen receptor gene: mutation screening and CAG repeat length analysis
    K Muroya
    Department of Paediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 Japan
    Mol Hum Reprod 7:409-13. 2001
    ..on mutation screening and CAG repeat length analysis of the androgen receptor (AR) gene in 21 patients with hypospadias. The urethral meatus was located at the glandular region in six patients (glandular type), at the penile shaft ..
  27. ncbi Pesticides and hypospadias: a meta-analysis
    Carissa M Rocheleau
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
    J Pediatr Urol 5:17-24. 2009
    To use meta-analytic techniques to synthesize the findings of the current body of published literature regarding the risk of hypospadias resulting from parental exposure to pesticides.
  28. ncbi Hypospadias: risk factor patterns and different phenotypes
    Marijn M Brouwers
    Department of Epidemiology, Biostatistics, and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 105:254-62. 2010
    To obtain more insight into the origin of hypospadias by exploring a wide range of potential risk factors in a case-referent study in which a distinction was made between different phenotypes.
  29. ncbi Mutational study of the MAMLD1-gene in hypospadias
    Yougen Chen
    Department of Urology, The Second Hospital, Shandong University, Jinan 250033, PR China
    Eur J Med Genet 53:122-6. 2010
    b>Hypospadias, when the urethral opening is situated on the ventral side of the penis, is a common genital malformation in boys and is partly caused by genetic factors...
  30. ncbi Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption
    Michael H Hsieh
    Scott Department of Urology, Texas Children s Hospital, Clinical Care Center, Baylor College of Medicine, Suite 660, 6621 Fannin Street, Houston, TX 77030, USA
    Curr Urol Rep 9:137-42. 2008
    Endocrine disruptors, such as environmental compounds with endocrine-altering properties, may cause hypospadias and cryptorchidism in several species, including humans...
  31. pmc The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency
    Birgit Kohler
    Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
    Eur J Endocrinol 161:237-42. 2009
    b>Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found...
  32. ncbi Reproductive dysgenesis in wildlife: a comparative view
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, 32611, USA
    Int J Androl 29:109-21. 2006
    ..in situ germ cell carcinoma of the testis and overt testicular cancer, reduced semen quality, and hypospadias. In this paper, we review examples of TDS among comparative species...
  33. ncbi Risk factors for hypospadias
    Marijn M Brouwers
    Department of Epidemiology and Biostatistics 133, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Pediatr 166:671-8. 2007
    Despite being one of the most common congenital defects in boys, the etiology of hypospadias remains largely unknown. In this case-referent study, we evaluated a wide spectrum of potential risk factors for hypospadias...
  34. pmc Polychlorinated biphenyls and risk of testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Res 69:1901-9. 2009
    ..006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT...
  35. ncbi What is new in cryptorchidism and hypospadias--a critical review on the testicular dysgenesis hypothesis
    Jorgen Thorup
    Department of Pediatric Surgery, Faculty of Health Science, University of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Pediatr Surg 45:2074-86. 2010
    It has been hypothesized that poor semen quality, testis cancer, undescended testis, and hypospadias are symptoms of one underlying entity--the testicular dysgenesis syndrome--leading to increasing male fertility impairment...
  36. ncbi Maternal use of oral contraceptives during early pregnancy and risk of hypospadias in male offspring
    Mette Nørgaard
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Urology 74:583-7. 2009
    To examine the association between maternal use of oral contraceptives in early pregnancy and increased prevalence of hypospadias in male offspring.
  37. ncbi Mutations of CXorf6 are associated with a range of severities of hypospadias
    Nicolas Kalfa
    Department of Pediatric Urology, Center for the Study and Treatment of Hypospadias, Children s Medical Center, University of California San Francisco, 400 Parnassus Avenue, A 640, San Francisco, California 94143, USA
    Eur J Endocrinol 159:453-8. 2008
    ..complex 46,XY disorders of sexual development (46,XY DSD) including micropenis, bifid scrotum, and penoscrotal hypospadias. The objective of this work was to identify genomic variants of CXorf6 in patients with isolated hypospadias, ..
  38. ncbi Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:298-303. 2010
    ..it suggested that impaired development of foetal testes could lead to increased risks of cryptorchidism, hypospadias, decreased spermatogenesis or testis cancer...
  39. ncbi Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias
    Ana Beleza-Meireles
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 158:729-39. 2008
    b>Hypospadias is a common inborn error of the genital development, whose complex etiology remains elusive. Defects of the androgen metabolism and activity have been found in a subset of boys with hypospadias...
  40. ncbi Placental insufficiency in early gestation is associated with hypospadias
    Takao Fujimoto
    Department of Pediatric Surgery, Imperial Gift Foundation, The Aiiku Maternal and Children s Medical Center, Minami Azabu, Minato ku, Tokyo 106 8580, Japan
    J Pediatr Surg 43:358-61. 2008
    The association of growth retardation and hypospadias is well established. Fetal testosterone secretion is under the influence of placental human chorionic gonadotropin during first 14 weeks of gestation...
  41. ncbi Outcome of hypospadias fistula repair
    K R Shankar
    Department of Paediatric Urology, Alder Hey Children s Hospital, Liverpool, UK
    BJU Int 89:103-5. 2002
    Objectives To examine the long-term results of hypospadias fistula repair, the factors involved in recurrence and the outcome in cases where this has occurred...
  42. ncbi Heredity of hypospadias and the significance of low birth weight
    Louise Fredell
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Urol 167:1423-7. 2002
    We analyzed a large group of patients with hypospadias regarding familial aggregation, phenotype, twin rate and ethnic origin and assessed the correlation of low birth weight with hypospadias.
  43. ncbi Hypospadias in the neonate
    Laura A Stokowski
    Inova Fairfax Hospital for Children, Neonatal Intensive Care Unit, Falls Church, VA 22042 3300, USA
    Adv Neonatal Care 4:206-15. 2004
    b>Hypospadias is a common developmental disorder of the urogenital tract, occurring in approximately 1 in 125 live male births...
  44. ncbi Outcome of proximal hypospadias repair using three different techniques
    Essam E Moursy
    Department of Urology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt
    J Pediatr Urol 6:45-53. 2010
    To evaluate the outcome of proximal hypospadias repair using three different techniques.
  45. ncbi Maternal age as a risk factor for hypospadias
    H Fisch
    Male Reproductive Center, Department of Urology and Babies Hospital, Columbia-Presbyterian Medical Center, Columbia University, American Infertility Association, New York, New York, USA
    J Urol 165:934-6. 2001
    PURPOSE: Hypospadias incidence rates have been widely reported to be increasing. During the last 20 years there has been a significant increase in the number of women who delay childbearing until their mid 30s...
  46. ncbi Aetiology of hypospadias: a systematic review of genes and environment
    L F M van der Zanden
    Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Hum Reprod Update 18:260-83. 2012
    b>Hypospadias is a common congenital malformation of the male external genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic and multifactorial forms, implicating both genes and environmental factors...
  47. pmc Expression of estrogen receptor alpha and beta is decreased in hypospadias
    Liang Qiao
    Division of Pediatric Urology, University of California, San Francisco Children s Hospital, San Francisco, California 94143, USA
    J Urol 187:1427-33. 2012
    Estrogenic endocrine disruptors acting via estrogen receptors α and β have been implicated in the etiology of hypospadias. However, the expression and distribution of estrogen receptors α and β in normal and hypospadiac human ..
  48. ncbi Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias
    Taiji Chen
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing, China
    Eur J Hum Genet 15:23-8. 2007
    b>Hypospadias, one of the most common congenital abnormalities of the male external genitalia with elusive etiology, are caused by a defect in the normal development of the urethra, foreskin and ventral aspect of the penis...
  49. ncbi Critical outcome analysis of staged buccal mucosa graft urethroplasty for prior failed hypospadias repair in children
    Bruno Leslie
    Division of Urology, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Urol 185:1077-82. 2011
    Although staged buccal mucosa graft urethroplasty is a well accepted technique for salvage urethroplasty, there are few reports on this procedure for redo hypospadias repair in children.
  50. ncbi Urethrocutaneous fistula after hypospadias repair: outcome of three types of closure techniques
    Kaliyaperumal Muruganandham
    Department of Urology, SGPGIMS, Lucknow, UP, India
    Pediatr Surg Int 26:305-8. 2010
    To evaluate the outcomes of three surgical techniques for the closure of urethrocutaneous fistula (UCF) after hypospadias repair.
  51. ncbi Abnormal urine flow in boys with distal hypospadias before and after correction
    K P Wolffenbuttel
    Departments of Pediatric Urology and Furore, Erasmus University Rotterdam, Sophia Children s Hospital, Dr Molewaterplein 60, 3016 GJ Rotterdam, The Netherlands
    J Urol 176:1733-6; discussion 1736-7. 2006
    We established the urine flow rate and the effect of surgical correction on that rate in patients with hypospadias.
  52. pmc A nested case-control study of intrauterine exposure to persistent organochlorine pollutants and the risk of hypospadias
    Anna Rignell-Hydbom
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    PLoS ONE 7:e44767. 2012
    ..to endocrine disrupting chemicals have been suggested as a risk factor for male genital abnormalities such as hypospadias. The aim of this case-control study was to investigate the association between fetal exposure to persistent ..
  53. ncbi Association between organic dietary choice during pregnancy and hypospadias in offspring: a study of mothers of 306 boys operated on for hypospadias
    Jeppe Schultz Christensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Urol 189:1077-82. 2013
    The etiology of hypospadias is poorly understood. Exposure to pesticides has been considered a risk factor, although findings are inconsistent...
  54. ncbi Unstented tubularized incised plate urethroplasty combined with foreskin reconstruction for distal hypospadias
    Marc David Leclair
    Department of Paediatric Urology, Service de Chirurgie Infantile, Hopital Mere Enfant, CHU de Nantes, 44093 Nantes Cedex 01, France
    Eur Urol 46:526-30. 2004
    ..We report our experience with unstented TIP repair combined with foreskin reconstruction for distal hypospadias in children.
  55. ncbi Hypospadias
    Aseem R Shukla
    Division of Urology, The Children s Hospital of Philadelphia, 3rd Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Urol Clin North Am 31:445-60, viii. 2004
    b>Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position anywhere along the penile shaft,scrotum, or perineum...
  56. ncbi The use of octyl cyanoacrylate (superglue) in hypospadias repair including its use as a fixator for urethral stents
    Hock Lim Tan
    Prince Court Medical Center, Kuala Lumpur, Malaysia
    J Pediatr Surg 47:2294-7. 2012
    Octyl cyanoacrylate has been used for many years for simple skin closure, but its use in hypospadias repair and as a urethral stent fixator has not been previously reported. We report our experience.
  57. ncbi Genomic variants of ATF3 in patients with hypospadias
    Nicolas Kalfa
    Center for Study and Treatment of Hypospadias, Department of Urology, University of California San Francisco Children s Medical Center, San Francisco, California 94143, USA
    J Urol 180:2183-8; discussion 2188. 2008
    ATF3, an estrogen responsive gene expressed during genital development, could be implicated in the etiology of hypospadias. ATF3 is up-regulated in the foreskin of patients with hypospadias and is implicated in suppression of the cell ..
  58. ncbi Use of buccal mucosa patch graft for recurrent large urethrocutaneous fistula after hypospadias repair
    Andras Kiss
    Department of Urology, Heim Pal Children s Hospital, Budapest, Hungary
    Urol Int 72:329-31; discussion 331. 2004
    To assess the effectiveness of buccal mucosa patch graft in the treatment of recurrent large urethrocutaneous fistula after hypospadias repair.
  59. ncbi The p.G146A and p.P125P polymorphisms in the steroidogenic factor-1 (SF-1) gene do not affect the risk for hypospadias in Caucasians
    T Adamovic
    Department of Women s and Children s Health and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Sex Dev 6:292-7. 2012
    b>Hypospadias is a frequent congenital malformation in boys and is characterized by incomplete fusion of the urethral folds...
  60. ncbi Semen quality, reproductive hormones and fertility of men operated for hypospadias
    C Asklund
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:80-7. 2010
    The testicular function of men previously operated for hypospadias has been sparsely investigated...
  61. ncbi Current concepts in hypospadias surgery
    Yutaro Hayashi
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Int J Urol 15:651-64. 2008
    Anatomical anomalies in hypospadias are an abnormal ventral opening of the urethral meatus, abnormal ventral curvature of the penis and abnormal distribution of the foreskin around the glans with a ventrally deficient hooded foreskin...
  62. ncbi Increasing prevalence of hypospadias associated with various perinatal risk factors in chinese newborns
    Ge Sun
    Neonatal Intensive Care Unit, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Urology 73:1241-5. 2009
    To evaluate the increasing trends of hypospadias and identify some of the perinatal risk factors that might be involved in Chinese newborns.
  63. pmc Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias
    Loes F M van der Zanden
    Department of Epidemiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Urol 188:2354-60. 2012
    b>Hypospadias is a common congenital malformation of the male external genitalia...
  64. ncbi Cryptorchidism and hypospadias in a cohort of 934,538 Danish boys: the role of birth weight, gestational age, body dimensions, and fetal growth
    Morten Søndergaard Jensen
    Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Denmark
    Am J Epidemiol 175:917-25. 2012
    ..and low birth weight are strong predictors of the urogenital anomalies cryptorchidism (undescended testis) and hypospadias. Understanding these associations may lead to important etiologic clues...
  65. ncbi Hypospadias: interactions between environment and genetics
    N Kalfa
    Service d Hormonologie, Hopital Lapeyronie, CHU de Montpellier et UM1, Montpellier, France
    Mol Cell Endocrinol 335:89-95. 2011
    b>Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated...
  66. ncbi Early closure of fistula after hypospadias surgery using N-butyl cyanoacrylate: preliminary results
    Steven P Lapointe
    Hospital of St Justine, Montreal, Canada
    J Urol 168:1751-3. 2002
    We determine the effectiveness of the tissue adhesive n-butyl cyanoacrylate for early repair of fistula after hypospadias surgery in children.
  67. ncbi Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias
    Rodolfo A Rey
    CEDIE, Hospital de Niños R Gutiérrez, Gallo 1330, C1425EFD Buenos Aires, Argentina
    J Clin Endocrinol Metab 90:6035-40. 2005
    Isolated hypospadias may result from impaired testicular function or androgen end-organ defects or, alternatively, from hormone-independent abnormalities of morphogenetic events responsible for urethral seam.
  68. ncbi The island flap technique for hypospadias repair. 1981
    John W Duckett
    J Urol 167:2148-52; discussion 2157-8. 2002
  69. ncbi The efficacy of dihydrotestosterone transdermal gel before primary hypospadias surgery: a prospective, controlled, randomized study
    Cevdet Kaya
    Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
    J Urol 179:684-8. 2008
    We sought to evaluate the efficacy of transdermal dihydrotestosterone treatment based on the results of hypospadias repair in children with primary hypospadias.
  70. pmc Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea: a comparison between industrialized areas of petrochemical estates and a non-industrialized area
    Sae Chul Kim
    Department of Urology, Chung Ang University College of Medicine, Seoul 156 756, Korea
    Asian J Androl 13:715-8. 2011
    This study aimed to represent the recent trends in the nationwide incidence of cryptorchidism and hypospadias in Korea, and to determine whether there is evidence of spatial heterogeneity in the incidence...
  71. ncbi Management of recurrent urethral fistulas after hypospadias repair
    Frank Richter
    Section of Urology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey, USA
    Urology 61:448-51. 2003
    ..To report on our experience in the management of recurrent urethrocutaneous fistulas in order to understand the etiology and outcome of secondary repair of the failed fistula closure...
  72. ncbi Introducing the HOPE (Hypospadias Objective Penile Evaluation)-score: a validation study of an objective scoring system for evaluating cosmetic appearance in hypospadias patients
    Fred van der Toorn
    Division Pediatric Urology, Sophia Children s Hospital, Erasmus Medical Center, P O Box 2060, 3000 CB Rotterdam, The Netherlands Electronic address
    J Pediatr Urol 9:1006-16. 2013
    To determine the reliability and internal validity of the Hypospadias Objective Penile Evaluation (HOPE)-score, a newly developed scoring system assessing the cosmetic outcome in hypospadias.
  73. ncbi The effect of intramuscular testosterone enanthate treatment on stretched penile length in prepubertal boys with hypospadias
    Tomohiro Ishii
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Urology 76:97-100. 2010
    To define the responses of stretched penile length (PL) to intramuscular testosterone enanthate (TE) treatment in prepubertal boys with hypospadias.
  74. ncbi Tubularized incised-plate urethroplasty for distal and proximal hypospadias
    M Samuel
    Department of Paediatric Urology, Great Ormond Street Hospital for Children NHS Trust, Guy s Hospital, and Institute of Child Health, London, UK
    BJU Int 92:783-5. 2003
    To describe the tubularized incised-plate (TIP) urethroplasty for distal and proximal hypospadias.
  75. ncbi Male reproductive disorders in humans and prenatal indicators of estrogen exposure. A review of published epidemiological studies
    Lone Storgaard
    Department of Occupational Medicine, University Hospital of Aarhus, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Reprod Toxicol 21:4-15. 2006
    ..led to the hypothesis that estrogens during fetal life may cause reduced sperm counts, cryptorchidism, hypospadias and testicular cancer. So far the hypothesis is based on animal studies and reports from the wild life...
  76. ncbi Combined buccal mucosa graft and dorsal penile skin flap for repair of severe hypospadias
    Miroslav L Djordjevic
    Department of Urology, School of Medicine, University of Belgrade, Belgrade, Serbia
    Urology 71:821-5. 2008
    Urethral reconstruction in severe hypospadias presents a great challenge. We have designed a method of combining a longitudinal dorsal island skin flap and buccal mucosa graft to create a neourethra in most severe hypospadias.
  77. ncbi Water consumption and use, trihalomethane exposure, and the risk of hypospadias
    Nina Iszatt
    Department of Epidemiology and Biostatistics and MRC HPA Centre for Environment and Health, Imperial College London, London, United Kingdom
    Pediatrics 127:e389-97. 2011
    b>Hypospadias is a congenital anomaly that affects up to 70 in 10 000 males. Ingestion of drinking-water-disinfection byproducts such as trihalomethanes (THMs) has been associated with hypospadias in a small sample...
  78. ncbi Long-term outcome of hypospadias surgery: current dilemmas
    Pierre D E Mouriquand
    Department of Paediatric Urology, Claude Bernard University Lyon 1, Lyon, France
    Curr Opin Urol 21:465-9. 2011
    To list the main questions and dilemmas raised by hypospadias management and its long-term evaluation.
  79. ncbi Training residents in hypospadias repair: variations of involvement
    Sean M DeLair
    Department of Urology, University of California, Davis Children s Hospital, Sacramento, California, USA
    J Urol 179:1102-6. 2008
    b>Hypospadias repair is a complex and seminal procedure that has defined the subspecialty of pediatric urology...
  80. ncbi Prenatal diagnosis of severe hypospadias with two- and three-dimensional sonography
    Daniel Cafici
    Department of Ultrasound and Prenatal Diagnosis, Clínica Privada Santa Ana, Buenos Aires, Argentina
    J Ultrasound Med 21:1423-6. 2002
  81. ncbi Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study
    Nicolas Kalfa
    Unité d Endocrinologie Gynécologie Pédiatrique, Service de Pediatrie I, Hopital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier, France
    Fertil Steril 95:2574-7. 2011
    ..cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
  82. ncbi Classification of prepuce in hypospadias according to morphological abnormalities and their impact on hypospadias repair
    Zoran I Radojicic
    University Children s Hospital, Belgrade, Serbia, Yugoslavia
    J Urol 172:301-4. 2004
    ..the morphology of the hypospadiac prepuce to develop a classification of different prepuce types in hypospadias. We also assessed the correlation between morphology and vascularization of the prepuce and their impact on ..
  83. ncbi Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias
    Fumihiro Sata
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Sex Med 7:2729-38. 2010
    b>Hypospadias is a common congenital anomaly caused by incomplete fusion of urethral folds. Development of the urethra and external genital system in the male fetus is an androgen-dependent process...
  84. ncbi Circumcised hypospadias
    Rafael V Pieretti
    Department of Pediatric Surgery, Section of Urology, Massachusetts General Hospital for Children, Boston, MA, USA
    Pediatr Surg Int 25:53-5. 2009
    Patients with circumcised hypospadias have been of significant concern over many decades due to the belief that prior circumcision might negatively affect the results of hypospadias' repair...
  85. ncbi Effect of suturing technique and urethral plate characteristics on complication rate following hypospadias repair: a prospective randomized study
    Osama Sarhan
    Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    J Urol 182:682-5; discussion 685-6. 2009
    ..We studied the effect of suturing technique and the impact of urethral plate characteristics on the complication rate following tubularized incised plate urethroplasty...
  86. ncbi [Laser hair removal for urethral hair after hypospadias repair]
    Tomoyuki Kaneko
    Department of Urology, Toshiba General Hospital
    Nihon Hinyokika Gakkai Zasshi 99:35-8. 2008
    ..About 50 years previously, he had undergone multi-staged urethroplasty for hypospadias. He had also suffered from recurrent urethral calculi managed by urethrolithotomy 5 and 2 years before the ..
  87. pmc Androgen receptor is overexpressed in boys with severe hypospadias, and ZEB1 regulates androgen receptor expression in human foreskin cells
    Liang Qiao
    University of California, San Francisco, Department of Urology, USA
    Pediatr Res 71:393-8. 2012
    ZEB1 is overexpressed in patients with severe hypospadias. We examined the interaction between ZEB1 and the androgen receptor (AR) in vitro and the expression of AR in boys with hypospadias.
  88. ncbi Outcomes of one-stage techniques for proximal hypospadias repair
    S Demirbilek
    Department of Pediatric Surgery, Harran University Faculty of Medicine, Sanliurfa, Turkey
    Urology 58:267-70. 2001
    OBJECTIVES: To evaluate the success of three preputial flap techniques in the one-stage correction of proximal hypospadias. METHODS: From 1993 to 1999, 43 children underwent one-stage proximal hypospadias repair using preputial flaps, ..
  89. ncbi Modified tubularized transverse preputial island flap repair for severe proximal hypospadias
    Rakesh P Patel
    Division of Paediatric Urology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BJU Int 95:901-4. 2005
  90. ncbi Chordee without hypospadias: report of 79 Chinese prepubertal patients
    Yun Man Tang
    Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China
    J Androl 28:630-3. 2007
    A series of Chinese prepubertal patients with congenital chordee without hypospadias is presented and the clinical data described...
  91. ncbi The 'learning curve' in hypospadias surgery
    Mark Horowitz
    Department of Urology, New York Weill Cornell, New York, NY, USA
    BJU Int 97:593-6. 2006
    To provide an insight into the 'learning curve' of fellowship-trained paediatric urologists associated with hypospadias repair, as hypospadias surgery is one of the most common yet difficult procedures used by the paediatric urologist.
  92. ncbi Use of tubularized incised plate urethroplasty for secondary hypospadias repair or repair in circumcised patients
    Seyed A Mousavi
    Department of Pediatric Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    Int Braz J Urol 34:609-14; discussion 614-6. 2008
    To retrospectively review our experience of the tubularized incised plate (TIP) urethroplasty in a series of re-operative hypospadias repairs or circumcised children.
  93. ncbi Surgical challenge in patients who underwent failed hypospadias repair: is it time to change?
    S Perovic
    Department of Urology, Clinical Centre Zvezdara, University of Belgrade, Belgrade, Serbia
    Urol Int 85:427-35. 2010
    Our purpose was to evaluate patients who underwent failed hypospadias repair.
  94. ncbi Urinary function after Snodgrass repair of distal hypospadias: comparison with the Mathieu repair
    Maria Grazia Scarpa
    Paediatric Surgery Unit, S Bortolo Hospital, Vicenza, Italy
    Pediatr Surg Int 26:519-22. 2010
    To evaluate urinary function in patients with distal hypospadias undergoing repair by the tubularized incised-plate urethroplasty (TIP or Snodgrass), compare the results with those in patients treated by the Mathieu technique, and show ..
  95. ncbi Analysis of risk factors for glans dehiscence after tubularized incised plate hypospadias repair
    Warren Snodgrass
    Pediatric Urology Section, University of Texas Southwestern Medical Center, Dallas, Texas 75207, USA
    J Urol 185:1845-9. 2011
    We determined the incidence of glans dehiscence and the associated risk factors after tubularized incised plate hypospadias repair.
  96. ncbi Early hypospadias surgery may lead to a better long-term psychosexual outcome
    Brendan C Jones
    School of Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Urol 182:1744-9. 2009
    We evaluated long-term outcomes in boys treated for hypospadias at Royal Children's Hospital, Melbourne.
  97. pmc Mutation analysis of NR5A1 encoding steroidogenic factor 1 in 77 patients with 46, XY disorders of sex development (DSD) including hypospadias
    Slimane Allali
    Universite Paris Descartes, Faculté de médecine and AP HP, Hopital Bicetre, Unité d endocrinologie, Pédiatrique, Le Kremlin Bicetre, France
    PLoS ONE 6:e24117. 2011
    Mutations of the NR5A1 gene encoding steroidogenic factor-1 have been reported in association with a wide spectrum of 46,XY DSD (Disorder of Sex Development) phenotypes including severe forms of hypospadias.
  98. pmc Correlation analysis of cocoa consumption data with worldwide incidence rates of testicular cancer and hypospadias
    Fabrizio Giannandrea
    Industrial and Environmental Hygiene Unit, Department of Animal and Human Biology, University Sapienza, Rome, Italy
    Int J Environ Res Public Health 6:568-78. 2009
    The underlying reasons for the increasing occurrence of male reproductive diseases (MRD) such as hypospadias, cryptorchidism, and testicular cancer (TC) over the last decades are still unknown...
  99. ncbi Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias
    A Allera
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857, USA
    J Clin Endocrinol Metab 80:2697-9. 1995
    Androgen receptor defects can cause severe hypospadias. To examine the possibility that androgen receptor defects are a common cause of such deficiencies, we have determined the coding sequence of the androgen receptor gene in nine ..
  100. ncbi Familial aggregation of hypospadias: a cohort study
    Tine H Schnack
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Am J Epidemiol 167:251-6. 2008
    b>Hypospadias is one of the most common birth defects. However, its etiology remains largely unknown. The authors investigated the contribution of genetic and environmental factors to familial aggregation of hypospadias...
  101. ncbi Surgical management of primary severe hypospadias in children: systematic 20-year review
    Marco Castagnetti
    Department of Oncological and Surgical Sciences, University Hospital of Padova, Padua, Italy
    J Urol 184:1469-74. 2010
    We systematically reviewed the literature published during the last 20 years on the treatment of primary proximal hypospadias associated with severe ventral curvature.

Research Grants62

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..transplants doubling donor organ pool;partial nephrectomy for benign and malignant lesions;urethral repair: for hypospadias, urethral stricture, urethral diverticulum, and urethral fistulae and all surgical procedures that currently ..
  2. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..Exposure to DEHP, a well-known endocrine disruptor, can lead to reproductive health issues including hypospadias, testicular cancer, and poor semen quality...
  3. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..together with the incidence of birth defects, particularly male urogenital defects including cryptorchidism and hypospadias. All of the necessary samples along with subject data, prospective biological samples and pregnancy outcomes ..
  4. A Developmental And Molecular Investigation Of How Vitamin E Ameliorates Endocrin
    Krista McCoy; Fiscal Year: 2013
    ..The most common of these defects, hypospadias, occurs when the urethral tube opens on the ventral side of the penis...
  5. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..of testicular cancer has increased and semen quality has decreased, and the incidences of cryptorchidism and hypospadias appear to have increased in certain regions...
  6. Directed differentiation of embryonic stem cells for urologic applications
    James A Bassuk; Fiscal Year: 2010
    ..sclerosis) and (ii) epithelial tubes for reconstruction of the urethra due to trauma, stricture disease or hypospadias (a common birth defect in boys)...
  7. Phthalates in Drugs and Male Genital Malformation
    Allen A Mitchell; Fiscal Year: 2012
    ..Prenatal exposure of male rats to DBP and DEHP has been shown to produce cryptorchidism and hypospadias, presumably due to their anti-androgenic activity...
  8. The role of Sprouty genes in development of mammalian external genitalia
    Ophir D Klein; Fiscal Year: 2012
    ..We have recently found that combined deletion of Spry1 and Spry2 in mice results in hypospadias, a congenital anomaly in which the urethral meatus is abnormally placed along the ventral side of the glans ..
  9. The role of MID1/MID2 in regulating epithelial adhesion
    CATHERINE KOTO; Fiscal Year: 2013
    ..loss of function of Midline-1 (MID1), is a disorder characterized by multiple developmental defects, including hypospadias and CLP...
  10. Genetics and the Environment Associated with Male Reproduction (GEAR)
    Sheela Sathyanarayana; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In specific areas of industrialized nations, the rising incidence of hypospadias and cryptorchidism from 1950- 2000 parallels the production and use of some phthalates, anti-androgenic synthetic ..
  11. Disorders of Sex Development: Platform for Basic and Translational Research
    ERIC J VILAIN; Fiscal Year: 2013
    ..Disorders of sex development (DSD) are phenotypically heterogeneous, ranging from minor genital malformations (hypospadias, cryptorchidism, hypertrophy of the clitoris) to genital ambiguity...
  12. Genes, environmental exposures, and hypospadias
    Suzan L Carmichael; Fiscal Year: 2012
    b>Hypospadias, a congenital malformation in which the urethral opening is on the ventral side of the penis, is one of the most common congenital malformations...
  13. Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine Disruption
    Kim Boekelheide; Fiscal Year: 2013
    ..According to this hypothesis, the observed abnormalities-including malformed external genitalia (hypospadias), undescended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer-result from ..
  14. Targets of Endocrine Disruptors in External Genitalia
    Martin J Cohn; Fiscal Year: 2013
    ..The most common anomaly of the genitourinary system is hypospadias, a malformation of the external genitalia that is characterized by failure of urethral tube closure and ..
  15. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..can vary from severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
  16. New Players in Urethral Closure;Defining the Role of a Novel Long Noncoding RNA
    Andrew J Pask; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hypospadias (the abnormal placement of the urethral opening) is one of the most common birth defects in the USA, affecting approximately 1 in every 140 live male births...
  17. Hypospadias: Morphogenesis of the Proximal Urethra
    Christine E Larkins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hypospadias is a congenital defect characterized by an ectopic opening of the urethra on the ventral side of the penis...
  18. 6th International Symposium on the Biology of Vertebrate Sex Determination
    Richard R Behringer; Fiscal Year: 2012
    ..result in clinically significant abnormalities that include intersexes, common genital abnormalities such as hypospadias, infertility, and pathologies such as cancer...
  19. 3D imaging and deep sequencing of gene expression in the genital tubercle
    Martin J Cohn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The most common anomaly of the genitourinary system is hypospadias, a malformation of the external genitalia that is characterized by failure of urethral tube closure and incomplete formation of the ..
  20. Statistical Methods in Genetic Epidemiology Research
    Jinbo Chen; Fiscal Year: 2012
    ..of Pennsylvania on which the PI is collaborating, and the phenotypes include pre-term birth, preeclampsia, hypospadias, and asthma...
  21. Hypospadias Differentiation and Endocrine Disrupters
    Laurence Baskin; Fiscal Year: 2013
    ..will also have translational relevance to a variety of disorders of sexual differentiation in humans including hypospadias. For example, abnormalities such as hypospadias might be explained by a disruption in the normal balance ..
  22. EXTERNAL GENITALIA DEVELOPMENT AND HYPOSPADIAS
    Liang Ma; Fiscal Year: 2013
    Genital malformation including hypospadias represents the second most common male birth defect after cardiac defect. In the past 40 years, hypospadias incidence has doubled along with other male reproductive problems...
  23. MOLECULAR EPIDEMIOLOGY OF BIRTH DEFECTS
    Jeanne Manson; Fiscal Year: 2001
    ..The research component describes a case-control study of the Molecular Epidemiology of Hypospadias in which gene by environment interactions are examined to understand risk factors for this birth defect...
  24. Manufacturing Process for Albumin-ICG Solder & Denatured Albumin Scaffold
    Yasmin Wadia; Fiscal Year: 2006
    ..17,300 patients on the waiting list); partial nephrectomy for benign lesions (500/year); Urethral repair: for hypospadias, urethral stricture, urethral diverticulum, and urethral fistulae (600/yr) and skin approximation (all surgical ..
  25. Gene Networks in Peri-pubertal Sertoli Cell Injury
    Mary L Hixon; Fiscal Year: 2010
    ..studies and registry surveys demonstrate that altered intrauterine growth increases the risks of congenital hypospadias, cryptorchidism and testicular cancer approximately 2- to 3-fold...
  26. Hypospadias: Interactions of Sex Steroids and Fgfr2
    Martin Cohn; Fiscal Year: 2006
    b>Hypospadias is a congenital malformation of the external genitalia that is characterized by a failure of urethral tube closure and incomplete formation of the prepuce and ventral penis...
  27. FIFTH INTERNATIONAL SYMPOSIUM ON THE BIOLOGY OF VERTEBRATE SEX DETERMINATION
    Richard Behringer; Fiscal Year: 2009
    ..result in clinically significant abnormalities that include intersexes, common genital abnormalities such as hypospadias, infertility, and pathologies such as cancer...
  28. CYTOCHROME P-450XVII GENE STRUCTURE AND REGULATION
    H Fevold; Fiscal Year: 1990
    ..type of congenital adrenal hyperplasia, which can result in hypertension, hyperkalemia, sexual infantilism and hypospadias. Therefore, the elucidation of the structural elements responsible for control of this P-450xvii gene is of ..
  29. Signaling during mammalian urogenital-anorectal develop
    Linda Baker; Fiscal Year: 2006
    ..For instance, hypospadias, which is due to a failure of the urethral epithelial cells to tubularize, occurs in approximately 1 out of ..
  30. The role of FoxA1 and FoxA2 in development of the anogenital system
    SARA ELIZABETH PATTERSON; Fiscal Year: 2009
    ..These range from hypospadias, a failure in urethral tube closure resulting in ectopic urethral openings, to persistent cloaca, in which a ..
  31. Cell Signaling and Lineage During Penile Development
    Martin Cohn; Fiscal Year: 2009
    ..The most common penile anomaly is hypospadias, which is characterized by failure of urethral tube closure, and is often accompanied by abnormal dorsal-..
  32. Fetal Origin of Male Reproductive Disorders
    Vassilios Papadopoulos; Fiscal Year: 2009
    ..development during human fetal life can result in testicular dysgenesis, manifested as undescended testis, hypospadias, poor semen quality, and testicular cancer...
  33. ORGANOCHLORINE PESTICIDES AND MALE GENITAL ANOMALIES
    Rajiv Bhatia; Fiscal Year: 2002
    ..The Investigators propose a nested case-control study of cryptorchidism and hypospadias and in utero exposure to DDT within the Child Health and Development Studies (CHDS) cohort...
  34. Murine Atlas of Genitourinary Smooth Muscle Development
    JAMES LESSARD; Fiscal Year: 2009
    ..e. hypospadias and cryptorchidism) are increasing...
  35. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..According to Skakkebaek, the observed abnormalities-including malformed external genitalia (hypospadias), undesecended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer- result from the ..
  36. Role of FKBP52 in androgen signaling and hypospadias
    Weinian Shou; Fiscal Year: 2009
    b>Hypospadias is a common birth defect. Although its etiology is unknown, it is generally considered to arise from androgen insensitivity...
  37. PATHOGENESIS OF PHTHALATE-INDUCED REPRODUCTIVE LESIONS
    NORMAN BARLOW; Fiscal Year: 2002
    ..These malformations include partially to completely absent epididymides, absent vasa deferentia and hypospadias. In addition, males exposed on GD 12 - 21 have decreased anogenital distances and increased incidence of ..
  38. Hypospadias and Genital Development Congress
    Laurence Baskin; Fiscal Year: 2001
    ..investigators who are actively involved in the various disciplines which define the leading edges of hypospadias and genital research...
  39. Risk Factors for Hypospadias
    Suzan Carmichael; Fiscal Year: 2009
    ..that interfere with maternal, fetal or placental sex steroid metabolism may be associated with increased hypospadias risk...
  40. Exogenous Stressors and Birth Defects Risks
    Suzan Carmichael; Fiscal Year: 2005
    ..This research will enhance scientific understanding of the causes of several common, costly, often deadly birth defects, which will undoubtedly have important implications for their risk assessment and prevention. ..
  41. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  42. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  43. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  44. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  45. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  46. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  47. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  48. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  49. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  50. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  51. The Role of Hormone Polymorphisms in Menstrual Function and Fertility
    CHANLEY SMALL; Fiscal Year: 2008
    ..The proposed pilot study is an efficient use of existing data and biological specimens to explore these relationships among a subset of important genes in reproductive function. [unreadable] [unreadable] [unreadable]..
  52. Lifestyle Factors and Type 2 Diabetes in Black Women
    Julie Palmer; Fiscal Year: 2008
    ..Because the follow-up and data collection are funded by another grant, the proposed large study of modifiable risk factors for type 2 diabetes can be carried out at a relatively modest cost. ..
  53. UROTHELIAL DIFFENTIATION
    Laurence Baskin; Fiscal Year: 2003
    ..Furthermore, we propose that abnormal epithelial-stroma signaling that occurs when intestinal segments are placed in contact with the bladder may lead to cellular changes such as atypia or even cancer. ..
  54. The World Congress on Chromosome Abnormalities
    Jannine Cody; Fiscal Year: 2004
    ..This application seeks funding for the Scientific Sessions of the World Congress on Chromosome Abnormalities, to be held in June of 2004 in San Antonio, Texas. ..
  55. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
  56. HOXA13 AMINO-TERMINAL FUNCTIONAL DOMAINS
    JEFFREY INNIS; Fiscal Year: 2004
    ..We will inject these modified ES cells into blastocysts to create chimeric mice, obtain germline transmission of the mutant alleles, and characterize the limb phenotypes associated with these mutations. ..
  57. Genomics of Human Fetal Morphogenesis
    Jeanne Manson; Fiscal Year: 2004
    ..abstract_text> ..
  58. AUTOSOMAL MECHANISMS OF TESTIS INDUCTION
    VICKI MEYERS WALLEN; Fiscal Year: 2005
    ..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
  59. Genetic Mechanisms of Vertebrate Caudal Limb Field Specification
    JEFFREY INNIS; Fiscal Year: 2007
    ..Public Health: This work will have broad significance to our understanding of embryonic development as well as the basis for very common human birth defects involving caudal structures and limbs. [unreadable] [unreadable] [unreadable]..
  60. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
  61. Identification of Dosage Sensitive Genes on 18q
    Jannine Cody; Fiscal Year: 2007
    ..Furthermore, it will begin to piece together the genotypic components that combine to generate the full phenotype of a child with an 18q deletion. ..
  62. Bladder Tissue Engineering through Nanotechnology
    Earl Cheng; Fiscal Year: 2006
    ..This proposed research will provide the first evaluation of a novel tissue engineering nanotechnology for bladder regeneration. [unreadable] [unreadable]..