Genomes and Genes
Summary: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.
Publications265 found, 100 shown here
- Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidismMichelle Welsh
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
J Clin Invest 118:1479-90. 2008..Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear...
- Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connectionJorma Toppari
Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
Birth Defects Res A Clin Mol Teratol 88:910-9. 2010Cryptorchidism and hypospadias are common genital birth defects that affect 2-9% and 0.2-1% of male newborns, respectively...
- Maternal reproductive and demographic characteristics as risk factors for hypospadiasSuzan L Carmichael
March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
Paediatr Perinat Epidemiol 21:210-8. 2007This study examined the association of hypospadias risk with several maternal reproductive and demographic characteristics: age, parity, body mass index (BMI), nausea and vomiting of pregnancy (NVP), multiple pregnancy, fertility ..
- Evidence for epigenetic abnormalities of the androgen receptor gene in foreskin from children with hypospadiasA Vottero
Department of Pediatrics, University of Parma, Via Gramsci 14, 43100 Parma, Italy
J Clin Endocrinol Metab 96:E1953-62. 2011b>Hypospadias is a malformation of the penis due to an incomplete development of the male urethra, the exact etiology of which in the majority of cases remains unknown.
- Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspectsN E Skakkebaek
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Hum Reprod 16:972-8. 2001..low and probably declining semen quality; high and possibly increasing frequencies of undescended testis and hypospadias; and an apparently growing demand for assisted reproduction...
- Genital anomalies in boys and the environmentKatharina M Main
University Department of Growth and Reproduction GR, Section 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Best Pract Res Clin Endocrinol Metab 24:279-89. 2010..These disorders are aetiologically linked with congenital cryptorchidism and hypospadias by common factors leading to perinatal disruption of normal testis differentiation, the testicular dysgenesis ..
- Hypospadias in males with intrauterine growth restriction due to placental insufficiency: the placental role in the embryogenesis of male external genitaliaYoav Yinon
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Placenta Clinic, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet A 152:75-83. 2010..the association between early onset intra-uterine growth restriction (IUGR) due to placental insufficiency and hypospadias in males...
- Urethral seam formation and hypospadiasL S Baskin
Department of Urology, University of California School of Medicine, San Francisco, CA 94143 0738, USA
Cell Tissue Res 305:379-87. 2001Knowledge of the formation of the normal male urethra may elucidate the etiology of hypospadias. We describe urethral formation in the mouse, show the similarities and relevance to human urethral development, and introduce the concept of ..
- The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case-control study in rural SicilyP Carbone
Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
Int J Androl 30:3-13. 2007..exposures to potential endocrine disrupting chemicals (EDC) assessed by questionnaire and cryptorchidism and hypospadias in their offspring in the agricultural area of Ragusa...
- Complex segregation analysis of hypospadiasLouise Fredell
Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital CMM 02, SE 171 76 Stockholm, Sweden
Hum Genet 111:231-4. 2002b>Hypospadias, when the urethra opens on the ventral side of the penis, is a common malformation seen in about 3 per 1000 male births...
- Maternal corticosteroid use and hypospadiasSuzan L Carmichael
California Research Division, March of Dimes Foundation, Oakland, CA 94609, USA
J Pediatr 155:39-44, 44.e1. 2009To explore whether women who reported corticosteroid use during pregnancy were more likely to deliver an infant with hypospadias than women who did not.
- Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patientsXian Yang Qin
Health Risk Research Section, Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
PLoS ONE 7:e36711. 2012..basis of the effect of BPA on human reproductive health, a genome-wide screen was performed using human foreskin fibroblast cells (hFFCs) derived from child hypospadias (HS) patients to identify novel targets of low-dose BPA exposure.
- Comparative analysis of tubularized incised plate versus onlay island flap urethroplasty for penoscrotal hypospadiasLuis H P Braga
Division of Urology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Urol 178:1451-6; discussion 1456-7. 2007Despite being the dominant technique for repair of distal hypospadias, application of the tubularized incised plate approach for penoscrotal hypospadias remains controversial...
- Rising hypospadias rates: disproving a mythHarry Fisch
Columbia University College of P and S, The Department of Urology, 219N, New York, NY 10463, USA
J Pediatr Urol 6:37-9. 2010b>Hypospadias is one of the most common congenital abnormalities occurring in males...
- Maternal diet and the risk of hypospadias and cryptorchidism in the offspringFelice Giordano
Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
Paediatr Perinat Epidemiol 22:249-60. 2008..The purpose of this study was to explore the association between hypospadias and cryptorchidism, and the dietary habits of an agricultural population in Italy...
- Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspringKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
Environ Health Perspect 117:1472-6. 2009The etiologies of the male urogenital anomalies cryptorchidism and hypospadias are poorly understood. It has been suggested, however, that in utero hormone levels may be related to risk...
- Correction of hypospadias with a vertical preputial island flap: a 23-year experienceNicolo Scuderi
Department of Plastic and Reconstructive Surgery, University of Rome La Sapienza, Rome, Italy
J Urol 175:1083-7; discussion 1087. 2006We report our experience using the preputial island flap technique (Scuderi procedure) to correct penile hypospadias.
- Molecular epidemiology of hypospadias: review of genetic and environmental risk factorsJeanne M Manson
Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Birth Defects Res A Clin Mol Teratol 67:825-36. 2003b>Hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 125 live male births. It is characterized by altered development of the urethra, foreskin, and ventral surface of the penis...
- Polymorphisms of MAMLD1 gene in hypospadiasN Kalfa
Service d Hormonologie, Hopital Lapeyronie, CHU de Montpellier et UM1, Montpellier, France
J Pediatr Urol 7:585-91. 2011..Almost 10% of patients with both severe and non-severe hypospadias exhibit mutations of MAMLD1...
- Common variants in DGKK are strongly associated with risk of hypospadiasLoes F M van der Zanden
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Nat Genet 43:48-50. 2011b>Hypospadias is a common congenital malformation of the male external genitalia...
- Endocrine disruptors, genital development, and hypospadiasMing Hsien Wang
UCSF Children s Hospital, Department of Urology, University of California, San Francisco, 400 Parnassus Avenue A640, San Francisco, CA 94143, USA
J Androl 29:499-505. 2008b>Hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 125 live male births...
- Mutation analysis of five candidate genes in Chinese patients with hypospadiasYanping Wang
Institute of Basic Medical Sciences, PUMC and CAMS, Beijing, 100005, China
Eur J Hum Genet 12:706-12. 2004b>Hypospadias is the displacement of the urethral meatus from the tip of the glans to the ventral side of the phallus...
- Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadiasXian Yang Qin
Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
J Hum Genet 57:434-41. 2012..RXRB, RXRG, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP3A4, CYP17A1 and CYP19A1) and risk of cryptorchidism (CO) and hypospadias (HS) in 334 Japanese (JPN) males (141 controls, 95 CO and 98 HS) and 187 Italian (ITA) males (129 controls and ..
- Screening for mutations in candidate genes for hypospadiasA Nordenskjold
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Urol Res 27:49-55. 1999b>Hypospadias. a condition with a frontally placed urethral orifice on the penis, is the most common malformation in males. During fetal development several components are necessary for normal male genital development...
- Algorithm for comprehensive approach to hypospadias reoperation using 3 techniquesWarren T Snodgrass
Pediatric Urology Section, Children s Medical Center, Dallas, Texas 75207, USA
J Urol 182:2885-91. 2009We describe comprehensive hypospadias reoperation based on presence or absence of a supple urethral plate using the 3 surgical techniques of transurethral incised plate, 1-stage inlay graft and 2-stage buccal graft.
- Hypospadias and the androgen receptor gene: mutation screening and CAG repeat length analysisK Muroya
Department of Paediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 Japan
Mol Hum Reprod 7:409-13. 2001..on mutation screening and CAG repeat length analysis of the androgen receptor (AR) gene in 21 patients with hypospadias. The urethral meatus was located at the glandular region in six patients (glandular type), at the penile shaft ..
- Pesticides and hypospadias: a meta-analysisCarissa M Rocheleau
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
J Pediatr Urol 5:17-24. 2009To use meta-analytic techniques to synthesize the findings of the current body of published literature regarding the risk of hypospadias resulting from parental exposure to pesticides.
- Hypospadias: risk factor patterns and different phenotypesMarijn M Brouwers
Department of Epidemiology, Biostatistics, and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
BJU Int 105:254-62. 2010To obtain more insight into the origin of hypospadias by exploring a wide range of potential risk factors in a case-referent study in which a distinction was made between different phenotypes.
- Mutational study of the MAMLD1-gene in hypospadiasYougen Chen
Department of Urology, The Second Hospital, Shandong University, Jinan 250033, PR China
Eur J Med Genet 53:122-6. 2010b>Hypospadias, when the urethral opening is situated on the ventral side of the penis, is a common genital malformation in boys and is partly caused by genetic factors...
- Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruptionMichael H Hsieh
Scott Department of Urology, Texas Children s Hospital, Clinical Care Center, Baylor College of Medicine, Suite 660, 6621 Fannin Street, Houston, TX 77030, USA
Curr Urol Rep 9:137-42. 2008Endocrine disruptors, such as environmental compounds with endocrine-altering properties, may cause hypospadias and cryptorchidism in several species, including humans...
- The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiencyBirgit Kohler
Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
Eur J Endocrinol 161:237-42. 2009b>Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found...
- Reproductive dysgenesis in wildlife: a comparative viewThea M Edwards
Department of Zoology, University of Florida, Gainesville, 32611, USA
Int J Androl 29:109-21. 2006..in situ germ cell carcinoma of the testis and overt testicular cancer, reduced semen quality, and hypospadias. In this paper, we review examples of TDS among comparative species...
- Risk factors for hypospadiasMarijn M Brouwers
Department of Epidemiology and Biostatistics 133, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Eur J Pediatr 166:671-8. 2007Despite being one of the most common congenital defects in boys, the etiology of hypospadias remains largely unknown. In this case-referent study, we evaluated a wide spectrum of potential risk factors for hypospadias...
- Polychlorinated biphenyls and risk of testicular germ cell tumorsKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Res 69:1901-9. 2009..006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT...
- What is new in cryptorchidism and hypospadias--a critical review on the testicular dysgenesis hypothesisJorgen Thorup
Department of Pediatric Surgery, Faculty of Health Science, University of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
J Pediatr Surg 45:2074-86. 2010It has been hypothesized that poor semen quality, testis cancer, undescended testis, and hypospadias are symptoms of one underlying entity--the testicular dysgenesis syndrome--leading to increasing male fertility impairment...
- Maternal use of oral contraceptives during early pregnancy and risk of hypospadias in male offspringMette Nørgaard
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
Urology 74:583-7. 2009To examine the association between maternal use of oral contraceptives in early pregnancy and increased prevalence of hypospadias in male offspring.
- Mutations of CXorf6 are associated with a range of severities of hypospadiasNicolas Kalfa
Department of Pediatric Urology, Center for the Study and Treatment of Hypospadias, Children s Medical Center, University of California San Francisco, 400 Parnassus Avenue, A 640, San Francisco, California 94143, USA
Eur J Endocrinol 159:453-8. 2008..complex 46,XY disorders of sexual development (46,XY DSD) including micropenis, bifid scrotum, and penoscrotal hypospadias. The objective of this work was to identify genomic variants of CXorf6 in patients with isolated hypospadias, ..
- Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesisN Jørgensen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Int J Androl 33:298-303. 2010..it suggested that impaired development of foetal testes could lead to increased risks of cryptorchidism, hypospadias, decreased spermatogenesis or testis cancer...
- Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadiasAna Beleza-Meireles
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Eur J Endocrinol 158:729-39. 2008b>Hypospadias is a common inborn error of the genital development, whose complex etiology remains elusive. Defects of the androgen metabolism and activity have been found in a subset of boys with hypospadias...
- Placental insufficiency in early gestation is associated with hypospadiasTakao Fujimoto
Department of Pediatric Surgery, Imperial Gift Foundation, The Aiiku Maternal and Children s Medical Center, Minami Azabu, Minato ku, Tokyo 106 8580, Japan
J Pediatr Surg 43:358-61. 2008The association of growth retardation and hypospadias is well established. Fetal testosterone secretion is under the influence of placental human chorionic gonadotropin during first 14 weeks of gestation...
- Outcome of hypospadias fistula repairK R Shankar
Department of Paediatric Urology, Alder Hey Children s Hospital, Liverpool, UK
BJU Int 89:103-5. 2002Objectives To examine the long-term results of hypospadias fistula repair, the factors involved in recurrence and the outcome in cases where this has occurred...
- Heredity of hypospadias and the significance of low birth weightLouise Fredell
Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
J Urol 167:1423-7. 2002We analyzed a large group of patients with hypospadias regarding familial aggregation, phenotype, twin rate and ethnic origin and assessed the correlation of low birth weight with hypospadias.
- Hypospadias in the neonateLaura A Stokowski
Inova Fairfax Hospital for Children, Neonatal Intensive Care Unit, Falls Church, VA 22042 3300, USA
Adv Neonatal Care 4:206-15. 2004b>Hypospadias is a common developmental disorder of the urogenital tract, occurring in approximately 1 in 125 live male births...
- Outcome of proximal hypospadias repair using three different techniquesEssam E Moursy
Department of Urology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt
J Pediatr Urol 6:45-53. 2010To evaluate the outcome of proximal hypospadias repair using three different techniques.
- Maternal age as a risk factor for hypospadiasH Fisch
Male Reproductive Center, Department of Urology and Babies Hospital, Columbia-Presbyterian Medical Center, Columbia University, American Infertility Association, New York, New York, USA
J Urol 165:934-6. 2001PURPOSE: Hypospadias incidence rates have been widely reported to be increasing. During the last 20 years there has been a significant increase in the number of women who delay childbearing until their mid 30s...
- Aetiology of hypospadias: a systematic review of genes and environmentL F M van der Zanden
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Hum Reprod Update 18:260-83. 2012b>Hypospadias is a common congenital malformation of the male external genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic and multifactorial forms, implicating both genes and environmental factors...
- Expression of estrogen receptor alpha and beta is decreased in hypospadiasLiang Qiao
Division of Pediatric Urology, University of California, San Francisco Children s Hospital, San Francisco, California 94143, USA
J Urol 187:1427-33. 2012Estrogenic endocrine disruptors acting via estrogen receptors α and β have been implicated in the etiology of hypospadias. However, the expression and distribution of estrogen receptors α and β in normal and hypospadiac human ..
- Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadiasTaiji Chen
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing, China
Eur J Hum Genet 15:23-8. 2007b>Hypospadias, one of the most common congenital abnormalities of the male external genitalia with elusive etiology, are caused by a defect in the normal development of the urethra, foreskin and ventral aspect of the penis...
- Critical outcome analysis of staged buccal mucosa graft urethroplasty for prior failed hypospadias repair in childrenBruno Leslie
Division of Urology, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
J Urol 185:1077-82. 2011Although staged buccal mucosa graft urethroplasty is a well accepted technique for salvage urethroplasty, there are few reports on this procedure for redo hypospadias repair in children.
- Urethrocutaneous fistula after hypospadias repair: outcome of three types of closure techniquesKaliyaperumal Muruganandham
Department of Urology, SGPGIMS, Lucknow, UP, India
Pediatr Surg Int 26:305-8. 2010To evaluate the outcomes of three surgical techniques for the closure of urethrocutaneous fistula (UCF) after hypospadias repair.
- Abnormal urine flow in boys with distal hypospadias before and after correctionK P Wolffenbuttel
Departments of Pediatric Urology and Furore, Erasmus University Rotterdam, Sophia Children s Hospital, Dr Molewaterplein 60, 3016 GJ Rotterdam, The Netherlands
J Urol 176:1733-6; discussion 1736-7. 2006We established the urine flow rate and the effect of surgical correction on that rate in patients with hypospadias.
- A nested case-control study of intrauterine exposure to persistent organochlorine pollutants and the risk of hypospadiasAnna Rignell-Hydbom
Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
PLoS ONE 7:e44767. 2012..to endocrine disrupting chemicals have been suggested as a risk factor for male genital abnormalities such as hypospadias. The aim of this case-control study was to investigate the association between fetal exposure to persistent ..
- Association between organic dietary choice during pregnancy and hypospadias in offspring: a study of mothers of 306 boys operated on for hypospadiasJeppe Schultz Christensen
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
J Urol 189:1077-82. 2013The etiology of hypospadias is poorly understood. Exposure to pesticides has been considered a risk factor, although findings are inconsistent...
- Unstented tubularized incised plate urethroplasty combined with foreskin reconstruction for distal hypospadiasMarc David Leclair
Department of Paediatric Urology, Service de Chirurgie Infantile, Hopital Mere Enfant, CHU de Nantes, 44093 Nantes Cedex 01, France
Eur Urol 46:526-30. 2004..We report our experience with unstented TIP repair combined with foreskin reconstruction for distal hypospadias in children.
- HypospadiasAseem R Shukla
Division of Urology, The Children s Hospital of Philadelphia, 3rd Floor, Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
Urol Clin North Am 31:445-60, viii. 2004b>Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position anywhere along the penile shaft,scrotum, or perineum...
- The use of octyl cyanoacrylate (superglue) in hypospadias repair including its use as a fixator for urethral stentsHock Lim Tan
Prince Court Medical Center, Kuala Lumpur, Malaysia
J Pediatr Surg 47:2294-7. 2012Octyl cyanoacrylate has been used for many years for simple skin closure, but its use in hypospadias repair and as a urethral stent fixator has not been previously reported. We report our experience.
- Genomic variants of ATF3 in patients with hypospadiasNicolas Kalfa
Center for Study and Treatment of Hypospadias, Department of Urology, University of California San Francisco Children s Medical Center, San Francisco, California 94143, USA
J Urol 180:2183-8; discussion 2188. 2008ATF3, an estrogen responsive gene expressed during genital development, could be implicated in the etiology of hypospadias. ATF3 is up-regulated in the foreskin of patients with hypospadias and is implicated in suppression of the cell ..
- Use of buccal mucosa patch graft for recurrent large urethrocutaneous fistula after hypospadias repairAndras Kiss
Department of Urology, Heim Pal Children s Hospital, Budapest, Hungary
Urol Int 72:329-31; discussion 331. 2004To assess the effectiveness of buccal mucosa patch graft in the treatment of recurrent large urethrocutaneous fistula after hypospadias repair.
- The p.G146A and p.P125P polymorphisms in the steroidogenic factor-1 (SF-1) gene do not affect the risk for hypospadias in CaucasiansT Adamovic
Department of Women s and Children s Health and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Sex Dev 6:292-7. 2012b>Hypospadias is a frequent congenital malformation in boys and is characterized by incomplete fusion of the urethral folds...
- Semen quality, reproductive hormones and fertility of men operated for hypospadiasC Asklund
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Int J Androl 33:80-7. 2010The testicular function of men previously operated for hypospadias has been sparsely investigated...
- Current concepts in hypospadias surgeryYutaro Hayashi
Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Int J Urol 15:651-64. 2008Anatomical anomalies in hypospadias are an abnormal ventral opening of the urethral meatus, abnormal ventral curvature of the penis and abnormal distribution of the foreskin around the glans with a ventrally deficient hooded foreskin...
- Increasing prevalence of hypospadias associated with various perinatal risk factors in chinese newbornsGe Sun
Neonatal Intensive Care Unit, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
Urology 73:1241-5. 2009To evaluate the increasing trends of hypospadias and identify some of the perinatal risk factors that might be involved in Chinese newborns.
- Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadiasLoes F M van der Zanden
Department of Epidemiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Urol 188:2354-60. 2012b>Hypospadias is a common congenital malformation of the male external genitalia...
- Cryptorchidism and hypospadias in a cohort of 934,538 Danish boys: the role of birth weight, gestational age, body dimensions, and fetal growthMorten Søndergaard Jensen
Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Denmark
Am J Epidemiol 175:917-25. 2012..and low birth weight are strong predictors of the urogenital anomalies cryptorchidism (undescended testis) and hypospadias. Understanding these associations may lead to important etiologic clues...
- Hypospadias: interactions between environment and geneticsN Kalfa
Service d Hormonologie, Hopital Lapeyronie, CHU de Montpellier et UM1, Montpellier, France
Mol Cell Endocrinol 335:89-95. 2011b>Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated...
- Early closure of fistula after hypospadias surgery using N-butyl cyanoacrylate: preliminary resultsSteven P Lapointe
Hospital of St Justine, Montreal, Canada
J Urol 168:1751-3. 2002We determine the effectiveness of the tissue adhesive n-butyl cyanoacrylate for early repair of fistula after hypospadias surgery in children.
- Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadiasRodolfo A Rey
CEDIE, Hospital de Niños R Gutiérrez, Gallo 1330, C1425EFD Buenos Aires, Argentina
J Clin Endocrinol Metab 90:6035-40. 2005Isolated hypospadias may result from impaired testicular function or androgen end-organ defects or, alternatively, from hormone-independent abnormalities of morphogenetic events responsible for urethral seam.
- The island flap technique for hypospadias repair. 1981John W Duckett
J Urol 167:2148-52; discussion 2157-8. 2002
- The efficacy of dihydrotestosterone transdermal gel before primary hypospadias surgery: a prospective, controlled, randomized studyCevdet Kaya
Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
J Urol 179:684-8. 2008We sought to evaluate the efficacy of transdermal dihydrotestosterone treatment based on the results of hypospadias repair in children with primary hypospadias.
- Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea: a comparison between industrialized areas of petrochemical estates and a non-industrialized areaSae Chul Kim
Department of Urology, Chung Ang University College of Medicine, Seoul 156 756, Korea
Asian J Androl 13:715-8. 2011This study aimed to represent the recent trends in the nationwide incidence of cryptorchidism and hypospadias in Korea, and to determine whether there is evidence of spatial heterogeneity in the incidence...
- Management of recurrent urethral fistulas after hypospadias repairFrank Richter
Section of Urology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey, USA
Urology 61:448-51. 2003..To report on our experience in the management of recurrent urethrocutaneous fistulas in order to understand the etiology and outcome of secondary repair of the failed fistula closure...
- Introducing the HOPE (Hypospadias Objective Penile Evaluation)-score: a validation study of an objective scoring system for evaluating cosmetic appearance in hypospadias patientsFred van der Toorn
Division Pediatric Urology, Sophia Children s Hospital, Erasmus Medical Center, P O Box 2060, 3000 CB Rotterdam, The Netherlands Electronic address
J Pediatr Urol 9:1006-16. 2013To determine the reliability and internal validity of the Hypospadias Objective Penile Evaluation (HOPE)-score, a newly developed scoring system assessing the cosmetic outcome in hypospadias.
- The effect of intramuscular testosterone enanthate treatment on stretched penile length in prepubertal boys with hypospadiasTomohiro Ishii
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
Urology 76:97-100. 2010To define the responses of stretched penile length (PL) to intramuscular testosterone enanthate (TE) treatment in prepubertal boys with hypospadias.
- Tubularized incised-plate urethroplasty for distal and proximal hypospadiasM Samuel
Department of Paediatric Urology, Great Ormond Street Hospital for Children NHS Trust, Guy s Hospital, and Institute of Child Health, London, UK
BJU Int 92:783-5. 2003To describe the tubularized incised-plate (TIP) urethroplasty for distal and proximal hypospadias.
- Male reproductive disorders in humans and prenatal indicators of estrogen exposure. A review of published epidemiological studiesLone Storgaard
Department of Occupational Medicine, University Hospital of Aarhus, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
Reprod Toxicol 21:4-15. 2006..led to the hypothesis that estrogens during fetal life may cause reduced sperm counts, cryptorchidism, hypospadias and testicular cancer. So far the hypothesis is based on animal studies and reports from the wild life...
- Combined buccal mucosa graft and dorsal penile skin flap for repair of severe hypospadiasMiroslav L Djordjevic
Department of Urology, School of Medicine, University of Belgrade, Belgrade, Serbia
Urology 71:821-5. 2008Urethral reconstruction in severe hypospadias presents a great challenge. We have designed a method of combining a longitudinal dorsal island skin flap and buccal mucosa graft to create a neourethra in most severe hypospadias.
- Water consumption and use, trihalomethane exposure, and the risk of hypospadiasNina Iszatt
Department of Epidemiology and Biostatistics and MRC HPA Centre for Environment and Health, Imperial College London, London, United Kingdom
Pediatrics 127:e389-97. 2011b>Hypospadias is a congenital anomaly that affects up to 70 in 10 000 males. Ingestion of drinking-water-disinfection byproducts such as trihalomethanes (THMs) has been associated with hypospadias in a small sample...
- Long-term outcome of hypospadias surgery: current dilemmasPierre D E Mouriquand
Department of Paediatric Urology, Claude Bernard University Lyon 1, Lyon, France
Curr Opin Urol 21:465-9. 2011To list the main questions and dilemmas raised by hypospadias management and its long-term evaluation.
- Training residents in hypospadias repair: variations of involvementSean M DeLair
Department of Urology, University of California, Davis Children s Hospital, Sacramento, California, USA
J Urol 179:1102-6. 2008b>Hypospadias repair is a complex and seminal procedure that has defined the subspecialty of pediatric urology...
- Prenatal diagnosis of severe hypospadias with two- and three-dimensional sonographyDaniel Cafici
Department of Ultrasound and Prenatal Diagnosis, Clínica Privada Santa Ana, Buenos Aires, Argentina
J Ultrasound Med 21:1423-6. 2002
- Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort studyNicolas Kalfa
Unité d Endocrinologie Gynécologie Pédiatrique, Service de Pediatrie I, Hopital Arnaud de Villeneuve, CHU Montpellier and Université Montpellier, France
Fertil Steril 95:2574-7. 2011..cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
- Classification of prepuce in hypospadias according to morphological abnormalities and their impact on hypospadias repairZoran I Radojicic
University Children s Hospital, Belgrade, Serbia, Yugoslavia
J Urol 172:301-4. 2004..the morphology of the hypospadiac prepuce to develop a classification of different prepuce types in hypospadias. We also assessed the correlation between morphology and vascularization of the prepuce and their impact on ..
- Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadiasFumihiro Sata
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Sex Med 7:2729-38. 2010b>Hypospadias is a common congenital anomaly caused by incomplete fusion of urethral folds. Development of the urethra and external genital system in the male fetus is an androgen-dependent process...
- Circumcised hypospadiasRafael V Pieretti
Department of Pediatric Surgery, Section of Urology, Massachusetts General Hospital for Children, Boston, MA, USA
Pediatr Surg Int 25:53-5. 2009Patients with circumcised hypospadias have been of significant concern over many decades due to the belief that prior circumcision might negatively affect the results of hypospadias' repair...
- Effect of suturing technique and urethral plate characteristics on complication rate following hypospadias repair: a prospective randomized studyOsama Sarhan
Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt
J Urol 182:682-5; discussion 685-6. 2009..We studied the effect of suturing technique and the impact of urethral plate characteristics on the complication rate following tubularized incised plate urethroplasty...
- [Laser hair removal for urethral hair after hypospadias repair]Tomoyuki Kaneko
Department of Urology, Toshiba General Hospital
Nihon Hinyokika Gakkai Zasshi 99:35-8. 2008..About 50 years previously, he had undergone multi-staged urethroplasty for hypospadias. He had also suffered from recurrent urethral calculi managed by urethrolithotomy 5 and 2 years before the ..
- Androgen receptor is overexpressed in boys with severe hypospadias, and ZEB1 regulates androgen receptor expression in human foreskin cellsLiang Qiao
University of California, San Francisco, Department of Urology, USA
Pediatr Res 71:393-8. 2012ZEB1 is overexpressed in patients with severe hypospadias. We examined the interaction between ZEB1 and the androgen receptor (AR) in vitro and the expression of AR in boys with hypospadias.
- Outcomes of one-stage techniques for proximal hypospadias repairS Demirbilek
Department of Pediatric Surgery, Harran University Faculty of Medicine, Sanliurfa, Turkey
Urology 58:267-70. 2001OBJECTIVES: To evaluate the success of three preputial flap techniques in the one-stage correction of proximal hypospadias. METHODS: From 1993 to 1999, 43 children underwent one-stage proximal hypospadias repair using preputial flaps, ..
- Modified tubularized transverse preputial island flap repair for severe proximal hypospadiasRakesh P Patel
Division of Paediatric Urology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
BJU Int 95:901-4. 2005
- Chordee without hypospadias: report of 79 Chinese prepubertal patientsYun Man Tang
Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China
J Androl 28:630-3. 2007A series of Chinese prepubertal patients with congenital chordee without hypospadias is presented and the clinical data described...
- The 'learning curve' in hypospadias surgeryMark Horowitz
Department of Urology, New York Weill Cornell, New York, NY, USA
BJU Int 97:593-6. 2006To provide an insight into the 'learning curve' of fellowship-trained paediatric urologists associated with hypospadias repair, as hypospadias surgery is one of the most common yet difficult procedures used by the paediatric urologist.
- Use of tubularized incised plate urethroplasty for secondary hypospadias repair or repair in circumcised patientsSeyed A Mousavi
Department of Pediatric Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Int Braz J Urol 34:609-14; discussion 614-6. 2008To retrospectively review our experience of the tubularized incised plate (TIP) urethroplasty in a series of re-operative hypospadias repairs or circumcised children.
- Surgical challenge in patients who underwent failed hypospadias repair: is it time to change?S Perovic
Department of Urology, Clinical Centre Zvezdara, University of Belgrade, Belgrade, Serbia
Urol Int 85:427-35. 2010Our purpose was to evaluate patients who underwent failed hypospadias repair.
- Urinary function after Snodgrass repair of distal hypospadias: comparison with the Mathieu repairMaria Grazia Scarpa
Paediatric Surgery Unit, S Bortolo Hospital, Vicenza, Italy
Pediatr Surg Int 26:519-22. 2010To evaluate urinary function in patients with distal hypospadias undergoing repair by the tubularized incised-plate urethroplasty (TIP or Snodgrass), compare the results with those in patients treated by the Mathieu technique, and show ..
- Analysis of risk factors for glans dehiscence after tubularized incised plate hypospadias repairWarren Snodgrass
Pediatric Urology Section, University of Texas Southwestern Medical Center, Dallas, Texas 75207, USA
J Urol 185:1845-9. 2011We determined the incidence of glans dehiscence and the associated risk factors after tubularized incised plate hypospadias repair.
- Early hypospadias surgery may lead to a better long-term psychosexual outcomeBrendan C Jones
School of Medicine, University of Melbourne, Parkville, Victoria, Australia
J Urol 182:1744-9. 2009We evaluated long-term outcomes in boys treated for hypospadias at Royal Children's Hospital, Melbourne.
- Mutation analysis of NR5A1 encoding steroidogenic factor 1 in 77 patients with 46, XY disorders of sex development (DSD) including hypospadiasSlimane Allali
Universite Paris Descartes, Faculté de médecine and AP HP, Hopital Bicetre, Unité d endocrinologie, Pédiatrique, Le Kremlin Bicetre, France
PLoS ONE 6:e24117. 2011Mutations of the NR5A1 gene encoding steroidogenic factor-1 have been reported in association with a wide spectrum of 46,XY DSD (Disorder of Sex Development) phenotypes including severe forms of hypospadias.
- Correlation analysis of cocoa consumption data with worldwide incidence rates of testicular cancer and hypospadiasFabrizio Giannandrea
Industrial and Environmental Hygiene Unit, Department of Animal and Human Biology, University Sapienza, Rome, Italy
Int J Environ Res Public Health 6:568-78. 2009The underlying reasons for the increasing occurrence of male reproductive diseases (MRD) such as hypospadias, cryptorchidism, and testicular cancer (TC) over the last decades are still unknown...
- Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadiasA Allera
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857, USA
J Clin Endocrinol Metab 80:2697-9. 1995Androgen receptor defects can cause severe hypospadias. To examine the possibility that androgen receptor defects are a common cause of such deficiencies, we have determined the coding sequence of the androgen receptor gene in nine ..
- Familial aggregation of hypospadias: a cohort studyTine H Schnack
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Am J Epidemiol 167:251-6. 2008b>Hypospadias is one of the most common birth defects. However, its etiology remains largely unknown. The authors investigated the contribution of genetic and environmental factors to familial aggregation of hypospadias...
- Surgical management of primary severe hypospadias in children: systematic 20-year reviewMarco Castagnetti
Department of Oncological and Surgical Sciences, University Hospital of Padova, Padua, Italy
J Urol 184:1469-74. 2010We systematically reviewed the literature published during the last 20 years on the treatment of primary proximal hypospadias associated with severe ventral curvature.
- Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: PreclinicYasmin Wadia; Fiscal Year: 2013..transplants doubling donor organ pool;partial nephrectomy for benign and malignant lesions;urethral repair: for hypospadias, urethral stricture, urethral diverticulum, and urethral fistulae and all surgical procedures that currently ..
- AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPTKassim Traore; Fiscal Year: 2013..Exposure to DEHP, a well-known endocrine disruptor, can lead to reproductive health issues including hypospadias, testicular cancer, and poor semen quality...
- Phthalate Exposure and Pregnancy OutcomeT Peter Stein; Fiscal Year: 2010..together with the incidence of birth defects, particularly male urogenital defects including cryptorchidism and hypospadias. All of the necessary samples along with subject data, prospective biological samples and pregnancy outcomes ..
- A Developmental And Molecular Investigation Of How Vitamin E Ameliorates EndocrinKrista McCoy; Fiscal Year: 2013..The most common of these defects, hypospadias, occurs when the urethral tube opens on the ventral side of the penis...
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..of testicular cancer has increased and semen quality has decreased, and the incidences of cryptorchidism and hypospadias appear to have increased in certain regions...
- Directed differentiation of embryonic stem cells for urologic applicationsJames A Bassuk; Fiscal Year: 2010..sclerosis) and (ii) epithelial tubes for reconstruction of the urethra due to trauma, stricture disease or hypospadias (a common birth defect in boys)...
- Phthalates in Drugs and Male Genital MalformationAllen A Mitchell; Fiscal Year: 2012..Prenatal exposure of male rats to DBP and DEHP has been shown to produce cryptorchidism and hypospadias, presumably due to their anti-androgenic activity...
- The role of Sprouty genes in development of mammalian external genitaliaOphir D Klein; Fiscal Year: 2012..We have recently found that combined deletion of Spry1 and Spry2 in mice results in hypospadias, a congenital anomaly in which the urethral meatus is abnormally placed along the ventral side of the glans ..
- The role of MID1/MID2 in regulating epithelial adhesionCATHERINE KOTO; Fiscal Year: 2013..loss of function of Midline-1 (MID1), is a disorder characterized by multiple developmental defects, including hypospadias and CLP...
- Genetics and the Environment Associated with Male Reproduction (GEAR)Sheela Sathyanarayana; Fiscal Year: 2012DESCRIPTION (provided by applicant): In specific areas of industrialized nations, the rising incidence of hypospadias and cryptorchidism from 1950- 2000 parallels the production and use of some phthalates, anti-androgenic synthetic ..
- Disorders of Sex Development: Platform for Basic and Translational ResearchERIC J VILAIN; Fiscal Year: 2013..Disorders of sex development (DSD) are phenotypically heterogeneous, ranging from minor genital malformations (hypospadias, cryptorchidism, hypertrophy of the clitoris) to genital ambiguity...
- Genes, environmental exposures, and hypospadiasSuzan L Carmichael; Fiscal Year: 2012b>Hypospadias, a congenital malformation in which the urethral opening is on the ventral side of the penis, is one of the most common congenital malformations...
- Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine DisruptionKim Boekelheide; Fiscal Year: 2013..According to this hypothesis, the observed abnormalities-including malformed external genitalia (hypospadias), undescended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer-result from ..
- Targets of Endocrine Disruptors in External GenitaliaMartin J Cohn; Fiscal Year: 2013..The most common anomaly of the genitourinary system is hypospadias, a malformation of the external genitalia that is characterized by failure of urethral tube closure and ..
- Murine Atlas of Genitourinary DevelopmentMelissa Little; Fiscal Year: 2009..can vary from severe (persistent cloaca, cystic kidney disease, hydronephrosis, diphallia) to more moderate (hypospadias, streak gonads, horseshoe kidney, micropenis, crytorchidism, unilateral renal agenesis)...
- New Players in Urethral Closure;Defining the Role of a Novel Long Noncoding RNAAndrew J Pask; Fiscal Year: 2013DESCRIPTION (provided by applicant): Hypospadias (the abnormal placement of the urethral opening) is one of the most common birth defects in the USA, affecting approximately 1 in every 140 live male births...
- Hypospadias: Morphogenesis of the Proximal UrethraChristine E Larkins; Fiscal Year: 2013DESCRIPTION (provided by applicant): Hypospadias is a congenital defect characterized by an ectopic opening of the urethra on the ventral side of the penis...
- 6th International Symposium on the Biology of Vertebrate Sex DeterminationRichard R Behringer; Fiscal Year: 2012..result in clinically significant abnormalities that include intersexes, common genital abnormalities such as hypospadias, infertility, and pathologies such as cancer...
- 3D imaging and deep sequencing of gene expression in the genital tubercleMartin J Cohn; Fiscal Year: 2013DESCRIPTION (provided by applicant): The most common anomaly of the genitourinary system is hypospadias, a malformation of the external genitalia that is characterized by failure of urethral tube closure and incomplete formation of the ..
- Statistical Methods in Genetic Epidemiology ResearchJinbo Chen; Fiscal Year: 2012..of Pennsylvania on which the PI is collaborating, and the phenotypes include pre-term birth, preeclampsia, hypospadias, and asthma...
- Hypospadias Differentiation and Endocrine DisruptersLaurence Baskin; Fiscal Year: 2013..will also have translational relevance to a variety of disorders of sexual differentiation in humans including hypospadias. For example, abnormalities such as hypospadias might be explained by a disruption in the normal balance ..
- EXTERNAL GENITALIA DEVELOPMENT AND HYPOSPADIASLiang Ma; Fiscal Year: 2013Genital malformation including hypospadias represents the second most common male birth defect after cardiac defect. In the past 40 years, hypospadias incidence has doubled along with other male reproductive problems...
- MOLECULAR EPIDEMIOLOGY OF BIRTH DEFECTSJeanne Manson; Fiscal Year: 2001..The research component describes a case-control study of the Molecular Epidemiology of Hypospadias in which gene by environment interactions are examined to understand risk factors for this birth defect...
- Manufacturing Process for Albumin-ICG Solder & Denatured Albumin ScaffoldYasmin Wadia; Fiscal Year: 2006..17,300 patients on the waiting list); partial nephrectomy for benign lesions (500/year); Urethral repair: for hypospadias, urethral stricture, urethral diverticulum, and urethral fistulae (600/yr) and skin approximation (all surgical ..
- Gene Networks in Peri-pubertal Sertoli Cell InjuryMary L Hixon; Fiscal Year: 2010..studies and registry surveys demonstrate that altered intrauterine growth increases the risks of congenital hypospadias, cryptorchidism and testicular cancer approximately 2- to 3-fold...
- Hypospadias: Interactions of Sex Steroids and Fgfr2Martin Cohn; Fiscal Year: 2006b>Hypospadias is a congenital malformation of the external genitalia that is characterized by a failure of urethral tube closure and incomplete formation of the prepuce and ventral penis...
- FIFTH INTERNATIONAL SYMPOSIUM ON THE BIOLOGY OF VERTEBRATE SEX DETERMINATIONRichard Behringer; Fiscal Year: 2009..result in clinically significant abnormalities that include intersexes, common genital abnormalities such as hypospadias, infertility, and pathologies such as cancer...
- CYTOCHROME P-450XVII GENE STRUCTURE AND REGULATIONH Fevold; Fiscal Year: 1990..type of congenital adrenal hyperplasia, which can result in hypertension, hyperkalemia, sexual infantilism and hypospadias. Therefore, the elucidation of the structural elements responsible for control of this P-450xvii gene is of ..
- Signaling during mammalian urogenital-anorectal developLinda Baker; Fiscal Year: 2006..For instance, hypospadias, which is due to a failure of the urethral epithelial cells to tubularize, occurs in approximately 1 out of ..
- The role of FoxA1 and FoxA2 in development of the anogenital systemSARA ELIZABETH PATTERSON; Fiscal Year: 2009..These range from hypospadias, a failure in urethral tube closure resulting in ectopic urethral openings, to persistent cloaca, in which a ..
- Cell Signaling and Lineage During Penile DevelopmentMartin Cohn; Fiscal Year: 2009..The most common penile anomaly is hypospadias, which is characterized by failure of urethral tube closure, and is often accompanied by abnormal dorsal-..
- Fetal Origin of Male Reproductive DisordersVassilios Papadopoulos; Fiscal Year: 2009..development during human fetal life can result in testicular dysgenesis, manifested as undescended testis, hypospadias, poor semen quality, and testicular cancer...
- ORGANOCHLORINE PESTICIDES AND MALE GENITAL ANOMALIESRajiv Bhatia; Fiscal Year: 2002..The Investigators propose a nested case-control study of cryptorchidism and hypospadias and in utero exposure to DDT within the Child Health and Development Studies (CHDS) cohort...
- Murine Atlas of Genitourinary Smooth Muscle DevelopmentJAMES LESSARD; Fiscal Year: 2009..e. hypospadias and cryptorchidism) are increasing...
- PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53Kim Boekelheide; Fiscal Year: 2007..According to Skakkebaek, the observed abnormalities-including malformed external genitalia (hypospadias), undesecended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer- result from the ..
- Role of FKBP52 in androgen signaling and hypospadiasWeinian Shou; Fiscal Year: 2009b>Hypospadias is a common birth defect. Although its etiology is unknown, it is generally considered to arise from androgen insensitivity...
- PATHOGENESIS OF PHTHALATE-INDUCED REPRODUCTIVE LESIONSNORMAN BARLOW; Fiscal Year: 2002..These malformations include partially to completely absent epididymides, absent vasa deferentia and hypospadias. In addition, males exposed on GD 12 - 21 have decreased anogenital distances and increased incidence of ..
- Hypospadias and Genital Development CongressLaurence Baskin; Fiscal Year: 2001..investigators who are actively involved in the various disciplines which define the leading edges of hypospadias and genital research...
- Risk Factors for HypospadiasSuzan Carmichael; Fiscal Year: 2009..that interfere with maternal, fetal or placental sex steroid metabolism may be associated with increased hypospadias risk...
- Exogenous Stressors and Birth Defects RisksSuzan Carmichael; Fiscal Year: 2005..This research will enhance scientific understanding of the causes of several common, costly, often deadly birth defects, which will undoubtedly have important implications for their risk assessment and prevention. ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- BIOENGINEERING OF BLADDER TISSUESAnthony Atala; Fiscal Year: 2003..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Insulin Producing Cells from Amniotic Stem Cells for Diabetes TherapyAnthony Atala; Fiscal Year: 2009..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- The Role of Hormone Polymorphisms in Menstrual Function and FertilityCHANLEY SMALL; Fiscal Year: 2008..The proposed pilot study is an efficient use of existing data and biological specimens to explore these relationships among a subset of important genes in reproductive function. [unreadable] [unreadable] [unreadable]..
- Lifestyle Factors and Type 2 Diabetes in Black WomenJulie Palmer; Fiscal Year: 2008..Because the follow-up and data collection are funded by another grant, the proposed large study of modifiable risk factors for type 2 diabetes can be carried out at a relatively modest cost. ..
- UROTHELIAL DIFFENTIATIONLaurence Baskin; Fiscal Year: 2003..Furthermore, we propose that abnormal epithelial-stroma signaling that occurs when intestinal segments are placed in contact with the bladder may lead to cellular changes such as atypia or even cancer. ..
- The World Congress on Chromosome AbnormalitiesJannine Cody; Fiscal Year: 2004..This application seeks funding for the Scientific Sessions of the World Congress on Chromosome Abnormalities, to be held in June of 2004 in San Antonio, Texas. ..
- Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular CellsD N Rao Veeramachaneni; Fiscal Year: 2007..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
- HOXA13 AMINO-TERMINAL FUNCTIONAL DOMAINSJEFFREY INNIS; Fiscal Year: 2004..We will inject these modified ES cells into blastocysts to create chimeric mice, obtain germline transmission of the mutant alleles, and characterize the limb phenotypes associated with these mutations. ..
- Genomics of Human Fetal MorphogenesisJeanne Manson; Fiscal Year: 2004..abstract_text> ..
- AUTOSOMAL MECHANISMS OF TESTIS INDUCTIONVICKI MEYERS WALLEN; Fiscal Year: 2005..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
- Genetic Mechanisms of Vertebrate Caudal Limb Field SpecificationJEFFREY INNIS; Fiscal Year: 2007..Public Health: This work will have broad significance to our understanding of embryonic development as well as the basis for very common human birth defects involving caudal structures and limbs. [unreadable] [unreadable] [unreadable]..
- Fetal Basis of Sexual Dysfunction: Brain DifferentiationD N Rao Veeramachaneni; Fiscal Year: 2007..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
- Identification of Dosage Sensitive Genes on 18qJannine Cody; Fiscal Year: 2007..Furthermore, it will begin to piece together the genotypic components that combine to generate the full phenotype of a child with an 18q deletion. ..
- Bladder Tissue Engineering through NanotechnologyEarl Cheng; Fiscal Year: 2006..This proposed research will provide the first evaluation of a novel tissue engineering nanotechnology for bladder regeneration. [unreadable] [unreadable]..