male infertility

Summary

Summary: Diminished or absent ability of the male to effect conception.

Top Publications

  1. ncbi The mouse Spo11 gene is required for meiotic chromosome synapsis
    P J Romanienko
    Genetics and Biochemistry Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 20892, Bethesda, MD, USA
    Mol Cell 6:975-87. 2000
  2. ncbi Oxidative stress and male infertility--a clinical perspective
    Kelton Tremellen
    Repromed, 180 Fullarton Road, Dulwich, 5065 Adelaide, South Australia, Australia
    Hum Reprod Update 14:243-58. 2008
  3. ncbi Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
    S M Baker
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
    Nat Genet 13:336-42. 1996
  4. pmc Mitochondria-related male infertility
    Kazuto Nakada
    Graduate School of Life and Environmental Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8572, Japan
    Proc Natl Acad Sci U S A 103:15148-53. 2006
  5. ncbi Men at risk: occupation and male infertility
    Paul Claman
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Ottawa Faculty of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
    Fertil Steril 81:19-26; quiz 57-60. 2004
  6. ncbi Meiotic sex chromosome inactivation
    James M A Turner
    Division of Stem Cell Biology and Developmental Genetics, MRC NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:1823-31. 2007
  7. ncbi miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis
    Wei Deng
    Department of Cell Biology, Duke University Medical Center, P O Box 3709, DUMC, Durham, NC 27710, USA
    Dev Cell 2:819-30. 2002
  8. ncbi Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele
    Ramadan A Saleh
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 80:1431-6. 2003
  9. ncbi The effect of obesity on sperm disorders and male infertility
    Stefan S du Plessis
    Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Nat Rev Urol 7:153-61. 2010
  10. ncbi Oxidative stress & male infertility
    Kartikeya Makker
    Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obsterics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Indian J Med Res 129:357-67. 2009

Research Grants

  1. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
  2. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
  3. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
  4. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    Clinton C MacDonald; Fiscal Year: 2013
  5. Model of the Human Testis for Reproductive Toxicology
    PAUL JACOB TUREK; Fiscal Year: 2011
  6. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
  7. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
  8. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
  9. The XXII nd North American Testis Workshop
    WILLIAM WALLACE WRIGHT; Fiscal Year: 2013
  10. Intratesticular Sex Steroids and Spermatogenesis in Man
    MARA YVONNE ROTH; Fiscal Year: 2013

Detail Information

Publications287 found, 100 shown here

  1. ncbi The mouse Spo11 gene is required for meiotic chromosome synapsis
    P J Romanienko
    Genetics and Biochemistry Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 20892, Bethesda, MD, USA
    Mol Cell 6:975-87. 2000
    ..We speculate that there is an additional role for Spo11, after it generates DSBs, in synapsis...
  2. ncbi Oxidative stress and male infertility--a clinical perspective
    Kelton Tremellen
    Repromed, 180 Fullarton Road, Dulwich, 5065 Adelaide, South Australia, Australia
    Hum Reprod Update 14:243-58. 2008
    ..Finally, the review will outline methods available for diagnosing oxidative stress and the various treatments available...
  3. ncbi Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
    S M Baker
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
    Nat Genet 13:336-42. 1996
    ..We also show that Mlh1 appears to localize to sites of crossing over on meiotic chromosomes. Together these findings suggest that Mlh1 is involved in DNA mismatch repair and meiotic crossing over...
  4. pmc Mitochondria-related male infertility
    Kazuto Nakada
    Graduate School of Life and Environmental Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8572, Japan
    Proc Natl Acad Sci U S A 103:15148-53. 2006
    ..patients with fertility problems, there is a possibility that mitochondrial respiration defects contribute to male infertility. To address this possibility, we used a transmitochondrial mouse model (mito-mice) carrying wild-type mtDNA ..
  5. ncbi Men at risk: occupation and male infertility
    Paul Claman
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Ottawa Faculty of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
    Fertil Steril 81:19-26; quiz 57-60. 2004
    There is accumulating evidence that workplace exposure to toxic substances contributes to male infertility. Men suffering from infertility problems may do well to look at their occupations, where exposure to certain substances may be a ..
  6. ncbi Meiotic sex chromosome inactivation
    James M A Turner
    Division of Stem Cell Biology and Developmental Genetics, MRC NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:1823-31. 2007
    ..Furthermore, failure in MSCI is emerging as an important etiological factor in meiotic sterility...
  7. ncbi miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis
    Wei Deng
    Department of Cell Biology, Duke University Medical Center, P O Box 3709, DUMC, Durham, NC 27710, USA
    Dev Cell 2:819-30. 2002
    ..Whereas MIWI and CREM do not regulate each other's expression, MIWI complexes with mRNAs of ACT and CREM target genes. Hence, MIWI may control spermiogenesis by regulating the stability of these mRNAs...
  8. ncbi Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele
    Ramadan A Saleh
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 80:1431-6. 2003
    ..To examine levels of sperm DNA damage and oxidative stress (OS) in infertile men with varicocele...
  9. ncbi The effect of obesity on sperm disorders and male infertility
    Stefan S du Plessis
    Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Nat Rev Urol 7:153-61. 2010
    ..Several mechanisms might account for the effect of obesity on male infertility, both directly and indirectly, by inducing sleep apnea, alterations in hormonal profiles (reduced inhibin B ..
  10. ncbi Oxidative stress & male infertility
    Kartikeya Makker
    Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obsterics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Indian J Med Res 129:357-67. 2009
    ..Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a ..
  11. ncbi EAU guidelines on male infertility
    G R Dohle
    Department of Urology, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur Urol 48:703-11. 2005
  12. pmc Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'
    Claire L Borg
    Department of Anatomy and Developmental Biology, The School of Biomedical Sciences, Monash University, Clayton 3800, Australia
    Hum Reprod Update 16:205-24. 2010
    ..A breakdown at any of these phases can result in male infertility. The production of mutant mouse models often yields an unexpected male infertility phenotype...
  13. ncbi Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception
    Margarida Fardilha
    Signal Transduction Laboratory, Center for Cell Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Ann N Y Acad Sci 1030:468-78. 2004
    ..alternatively spliced proteins as targets for the development of novel therapeutic strategies for male infertility and contraception is discussed...
  14. pmc Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia
    Guntram Bezold
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Fertil Steril 87:1087-97. 2007
    ..the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers, and ..
  15. pmc Eurycoma longifolia Jack in managing idiopathic male infertility
    Mohd Ismail Bin Mohd Tambi
    Wellmen Clinic, Damai Service Hospital, Kuala Lumpur 52100, Malaysia
    Asian J Androl 12:376-80. 2010
    ..The proprietary extract of Eurycoma longifolia Jack significantly improved the sperm quality in these patients, allowing for 11 (14.7%) spontaneous pregnancies...
  16. ncbi Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility
    Jinu Lee
    Department of Pharmacology, CHA Stem Cell Institute, School of Medicine, CHA University, Bundang gu, Seongnam si, Kyunggi Do, Korea
    J Cell Mol Med 13:1942-51. 2009
    ..A male infertility-associated single nucleotide polymorphism (-9C > T) within the 5' untranslated region (5'UTR) of the ..
  17. ncbi Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    BJU Int 95:503-7. 2005
  18. ncbi Pathophysiology of varicoceles in male infertility
    C K Naughton
    Center for Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Hum Reprod Update 7:473-81. 2001
    Varicoceles are found in 19 to 41% of infertile men, and is one treatable form of male infertility. The mechanism by which varicoceles cause the variable effect on male infertility and spermatogenesis is still unknown...
  19. ncbi Oxidative stress, DNA damage and the Y chromosome
    R J Aitken
    School of Biological and Chemical Sciences, Centre for Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 23008, Australia
    Reproduction 122:497-506. 2001
    Recent advances in understanding of male infertility have implicated two major causative factors, oxidative stress and Y chromosome deletions...
  20. pmc The Y deletion gr/gr and susceptibility to testicular germ cell tumor
    Katherine L Nathanson
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 77:1034-43. 2005
    ..In epidemiological studies, male infertility has shown an association with TGCT that is out of proportion with what can be explained by tumor effects...
  21. ncbi Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis
    Marcello Cocuzza
    Reproductive Research Center, Glickman Urological and Kidney Institute, Department of Obstetrics Gynecology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Int Braz J Urol 33:603-21. 2007
    ..Thus evaluation of seminal ROS levels and extent of sperm DNA damage especially in an infertile male may help develop new therapeutic strategies and improve success of assisted reproductive techniques (ART)...
  22. ncbi CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations
    Kumarasamy Thangaraj
    Centre for Cellular and Molecular Biology, Hyderabad, India
    J Androl 23:815-8. 2002
    CAG repeat expansion in exon 1 of the androgen receptor (AR) gene has been reported to be associated with male infertility in some but not all populations...
  23. ncbi Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques
    Donald P Evenson
    Olson Biochemistry Laboratories, South Dakota State University, Brookings 57006, USA
    J Androl 23:25-43. 2002
  24. pmc Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice
    Derek Paisley
    Molecular Medicine Centre, University of Edinburgh, Edinburgh, Scotland
    Am J Pathol 164:2279-88. 2004
    ..Therefore we found no evidence that Dpl compensates for the loss of PrP function in mutant mouse lines, but it does have an important anti-oxidant function necessary for sperm integrity and male fertility...
  25. ncbi Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility
    Tamer M Said
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, OH 44195, USA
    Fertil Steril 82:871-7. 2004
    ..generation in infertile men and determine whether sperm quality is correlated with levels of ROS triggered by the exogenous reduced form of beta nicotinamide adenine dinucleotide phosphate (NADPH)...
  26. ncbi The present and future state of hormonal treatment for male infertility
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, New South Wales, Australia
    Hum Reprod Update 9:9-23. 2003
    ..One uncommon but treatable cause of male infertility is gonadotrophin deficiency in which gonadotrophin replacement therapy is highly effective at inducing ..
  27. ncbi Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial
    F H Comhaire
    Ghent University Hospital, Department of Medical and Urological Andrology, 9k12 IE, De Pintelaan, 185, B 9000, Gent, Belgium
    Asian J Androl 7:257-62. 2005
    To evaluate the treatment of male infertility with a strong natural antioxidant, in addition to conventional treatment.
  28. ncbi Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism
    Darius A Paduch
    Department of Urology, Weill Medical College of Cornell University, 525 East 68th Street, Box 580, New York, NY 10021, USA
    Reprod Biomed Online 10:747-54. 2005
    ..The USP26 gene may be of importance in male reproduction. Mutations in this gene may be associated with male infertility, and may negatively affect testicular function.
  29. ncbi Protamines and male infertility
    Rafael Oliva
    Human Genetics Laboratory, Genetics Unit, Department of Ciències Fisiològiques I, Faculty of Medicine, University of Barcelona and Hospital Clínic, IDIBAPS, Casanova 143, 08036 Barcelona, Spain
    Hum Reprod Update 12:417-35. 2006
    ..The present work reviews the articles published to date on the relationship between protamines and infertility...
  30. ncbi Contribution of environmental factors to the risk of male infertility
    A Oliva
    Unidad de Andrologia, Hospital Italiano Garibaldi, 2000 Rosario, Argentina
    Hum Reprod 16:1768-76. 2001
    ..CONCLUSION: We have shown that environmental factors contribute to the severity of infertility, and that this may worsen the effects of pre-existing genetic or medical risk factors...
  31. ncbi Best practice policies for male infertility
    Ira D Sharlip
    Pan Pacific Urology, University of California, California, San Francisco, USA
    Fertil Steril 77:873-82. 2002
  32. pmc Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Proc Natl Acad Sci U S A 93:3264-8. 1996
    ..These results suggest that HSP70-2 participates in synaptonemal complex function during meiosis in male germ cells and is linked to mechanisms that inhibit apoptosis...
  33. ncbi Expression failure of the Notch signaling system is associated with the pathogenesis of maturation arrest in male infertility patients
    Tetsuo Hayashi
    Fertil Steril 81:697-9. 2004
    ..The receptor or ligand of the Notch signaling system fails to express in the germ cells of maturation arrest patients, indicating that this signaling system is associated with for the pathogenesis of maturation arrest...
  34. ncbi Female subfertility
    Johannes L H Evers
    Department of Obstetrics and Gynaecology, Research Institute GROW, Academisch Ziekenhuis Maastricht, and Maastricht University, Maastricht, Netherlands
    Lancet 360:151-9. 2002
    ..has sufficient exposure to the chance of conception taken place? Are cost-effective, safe, and reliable treatments available for the disorder diagnosed? And, should the couple be referred straightaway for assisted reproduction?..
  35. ncbi Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility
    Jie Zhang
    Department of Anatomy, Histology and Embryology, Medical College of Xi an Jiaotong University, Xi an 710061, China
    Asian J Androl 9:809-14. 2007
    To study the incidence of single nucleotide polymorphisms in ubiquitin-specific protease 26 (USP26) gene and its involvement in idiopathic male infertility in China.
  36. ncbi Chronic orchitis: a neglected cause of male infertility?
    H C Schuppe
    Centre of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Andrologia 40:84-91. 2008
    ..inflammatory reactions in the testis should not be neglected as an underlying cause or co-factor of male infertility. However, definitive diagnosis of chronic asymptomatic orchitis still requires testicular biopsy and ..
  37. ncbi Sperm DNA damage: importance in the era of assisted reproduction
    Armand Zini
    Division of Urology, Department of Surgery, McGill University, and St Mary s Hospital, 3830 Lacombe Avenue, Montreal, Quebec, Canada
    Curr Opin Urol 16:428-34. 2006
    ..To date, these consequences are still largely unknown...
  38. pmc Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency
    Bingfang Xu
    Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Dev Biol 319:211-22. 2008
    ....
  39. ncbi Male infertility: role of genetic background
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 14:734-45. 2007
    b>Male infertility represents one of the clearest examples of a complex disease with a substantial genetic basis...
  40. ncbi Origins and consequences of DNA damage in male germ cells
    R John Aitken
    ARC Centre of Excellence in Biotechnology and Development and Discipline of Biological Sciences, University of Newcastle, NSW 2308, Australia
    Reprod Biomed Online 14:727-33. 2007
    ..Ultimately, resolving the precise nature of the DNA lesions present in the spermatozoa of infertile men will be an important step towards uncovering the aetiology of this damage and developing strategies for its clinical management...
  41. ncbi Genetic dissection of mammalian fertility pathways
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 4:s41-9. 2002
    ....
  42. ncbi Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility
    S Venkatesh
    Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 129:127-37. 2009
    ..mtDNA mutations are considered to be the major aetiological factors in a variety of human diseases including male infertility. Identification of novel mutations in mtDNA of infertile patients with supraphysiological levels of ROS are ..
  43. pmc Sperm preparation for ART
    Ralf R Henkel
    Department of Dermatology and Andrology, Justus Liebig University, Giessen, Gaffkystr, 14, Germany
    Reprod Biol Endocrinol 1:108. 2003
    ..The older method, by which the ejaculate is forcefully aspirated through a narrow-gauge needle, should be abandoned as it can severely damage spermatozoa, thus resulting in immotile sperm...
  44. ncbi Gene polymorphisms and male infertility--a meta-analysis and literature review
    Frank Tüttelmann
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Reprod Biomed Online 15:643-58. 2007
    Many genetic polymorphisms have been studied extensively to elucidate their role in the pathophysiology of male infertility. This article presents a review of the literature following a thorough search of PubMed, a compilation of meta-..
  45. pmc Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house mice
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Evolution 62:50-65. 2008
    ..These data build on previous studies of speciation in house mice and show that the genetic basis of hybrid male sterility is fairly complex, even at this early stage of divergence...
  46. ncbi The metabolic syndrome and male infertility
    Sanjay S Kasturi
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave, Tarry16 703, Chicago, IL 60611, USA
    J Androl 29:251-9. 2008
    ..At the end of this manuscript, we propose a new MetS/male infertility paradigm...
  47. pmc The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice
    David H Volle
    INSERM U895, Centre Méditerranéen de Médecine Moléculaire, Hôpital L Archet 2, Nice, France
    J Clin Invest 119:3752-64. 2009
    ..Together, these data demonstrate that Nr0b2 plays a critical role in the pathophysiological changes induced by DES in the mouse testis...
  48. ncbi Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice
    Claus Rodemer
    Universitat Heidelberg, Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    Hum Mol Genet 12:1881-95. 2003
    ..The mutant mice revealed multiple abnormalities, such as male infertility, defects in eye development, cataract and optic nerve hypoplasia, some of which were also observed in RCDP...
  49. ncbi Genetics of human male infertility
    J Poongothai
    Computational Engineering and Networking Department, Amrita Viswha Vidyapeetham, Ettimadai, Coimbatore 638107, Tamil Nadu, India
    Singapore Med J 50:336-47. 2009
    ..b>Male infertility is a multifactorial syndrome encompassing a wide variety of disorders...
  50. ncbi Spermatogenesis in a man with complete deletion of USP9Y
    Alice Luddi
    Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Italy
    N Engl J Med 360:881-5. 2009
    ..These results suggest that it may not be necessary to consider USP9Y when screening the Y chromosome of infertile or subfertile men for microdeletions...
  51. ncbi Partial AZFc deletions and duplications: clinical correlates in the Italian population
    Claudia Giachini
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    Hum Genet 124:399-410. 2008
    ....
  52. ncbi Genomic instability in mice lacking histone H2AX
    Arkady Celeste
    Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Science 296:922-7. 2002
    ..Thus, H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA...
  53. ncbi Sperm chromatin structure and male fertility: biological and clinical aspects
    J Erenpreiss
    University of Lund, Fertility Centre, Malmo University Hospital, Malmo SE 205 02, Sweden
    Asian J Androl 8:11-29. 2006
    ..Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed...
  54. ncbi Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI
    Robert D Oates
    Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Boston, MA 02118, USA
    Hum Reprod 17:2813-24. 2002
    ..In this study, we have fully characterized 42 infertile men with a Y chromosome microdeletion strictly confined to the AZFc region, and we report on 18 children conceived through the use of ICSI...
  55. ncbi Oxidative stress and medical antioxidant treatment in male infertility
    Francesco M Lanzafame
    Territorial Center of Andrology, AUSL 8, Syracuse, Italy
    Reprod Biomed Online 19:638-59. 2009
    Oxidative stress (OS) has been recognized as one of the most important cause of male infertility. Despite the antioxidant activity of seminal plasma, epididymis and spermatozoa, OS damages sperm function and DNA integrity...
  56. ncbi Seminal tract infections: impact on male fertility and treatment options
    C Keck
    Department of Obstetrics and Gynecology at the University, Freiburg, Germany
    Hum Reprod Update 4:891-903. 1998
    Bacterial and viral infections of the genital tract may be important aetiological factors for male infertility. Infectious processes may lead to deterioration of spermatogenesis, impairment of sperm function and/or obstruction of the ..
  57. ncbi Role of antioxidants in the treatment of male infertility
    John C Kefer
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Int J Urol 16:449-57. 2009
    b>Male infertility continues to be a clinical challenge of increasing significance...
  58. pmc Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1
    Anu Bashamboo
    Human Developmental Genetics, Institut Pasteur, 75724 Paris, France
    Am J Hum Genet 87:505-12. 2010
    ..To test the hypothesis that mutations in NR5A1 cause male infertility, we sequenced NR5A1 in 315 men with idiopathic spermatogenic failure...
  59. pmc PICK1 deficiency causes male infertility in mice by disrupting acrosome formation
    Nan Xiao
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    J Clin Invest 119:802-12. 2009
    ..Our results suggest that PICK1 is involved in vesicle trafficking from the Golgi apparatus to the acrosome and cooperates with other proteins such as GOPC and CK2alpha' in acrosome biogenesis...
  60. ncbi Male infertility and the involvement of the X chromosome
    Katrien Stouffs
    Department of Embryology and Genetics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod Update 15:623-37. 2009
    b>Male infertility is a worldwide problem, keeping many researchers puzzled. Besides environmental factors, much attention is paid to single gene defects...
  61. pmc Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia
    Anika H D M Dam
    Centre for Reproduction, Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Hum Genet 81:813-20. 2007
    ..This is the first example of a nonsyndromic male infertility condition in humans caused by an autosomal gene defect, and it could also mean that the identification of ..
  62. ncbi The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation
    Jose Luis Fernandez
    Sección de Genética y Unidad de Investigación, Hospital Teresa Herrera, Complejo Hospitalario Juan Canalejo, La Coruna, Spain
    J Androl 24:59-66. 2003
    ..Therefore, the SCD test could potentially be used as a routine test for the screening of sperm DNA fragmentation in the andrology laboratory...
  63. ncbi Globozoospermia revisited
    A H D M Dam
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Reprod Update 13:63-75. 2007
    Globozoospermia is a rare (incidence <0.1%) but severe disorder in male infertility. Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa lacking an acrosome...
  64. ncbi Role of caspases in male infertility
    Tamer M Said
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A19 1, Cleveland, OH 44195, USA
    Hum Reprod Update 10:39-51. 2004
    ..In this review, we summarize the consequences of caspase activation, aiming to clarify their role in the pathogenesis of male infertility.
  65. ncbi The Y chromosome gr/gr subdeletion is associated with male infertility
    M Lynch
    Prince Henry s Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Victoria, Australia
    Mol Hum Reprod 11:507-12. 2005
    ..A total of 788 men from the Monash Male Infertility (MMI) database with a range of fertility disorders showed similar overall prevalences of AZFc (2...
  66. ncbi Role of sperm chromatin abnormalities and DNA damage in male infertility
    A Agarwal
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Hum Reprod Update 9:331-45. 2003
    ..Any form of sperm chromatin abnormalities or DNA damage may result in male infertility. In support of this conclusion, it was reported that in-vivo fecundity decreases progressively when > 30% ..
  67. ncbi Male infertility in cancer patients: Review of the literature
    Gert R Dohle
    Department of Urology, Erasmus MC, Rotterdam, The Netherlands
    Int J Urol 17:327-31. 2010
    ....
  68. ncbi Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility
    M Ollero
    Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Hum Reprod 16:1912-21. 2001
    ..damage of membrane phospholipids and DNA in human spermatozoa has been implicated in the pathogenesis of male infertility. In this study, variations in ROS production, DNA structure (as measured by the sperm chromatin structure ..
  69. ncbi HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells
    Li yi Cai
    Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa 214 8571, Japan
    Reprod Toxicol 27:14-21. 2009
    ..1 thymidine kinase (HSV1-TK)-introduced transgenic rodents and HSV-infected humans were reported to suffer male infertility. The present study aimed to find novel clues to clarify the cause of HSV1-TK-induced male infertility using ..
  70. ncbi Chlamydia trachomatis and male infertility in Tunisia
    R Gdoura
    Laboratory of Bacteriology-Virology, University School of Medicine Sfax, Tunisia
    Eur J Contracept Reprod Health Care 6:102-7. 2001
    ..of infertile couples in Tunisia and to assess the relationship between chlamydial infection markers and male infertility. METHODS: Chlamydial DNA in urethral and in semen specimens was determined by using the Cobas Amplicor ..
  71. ncbi Effects of transmission of Y chromosome AZFc deletions
    Philippos C Patsalis
    Cyprus Institute of Neurology and Genetics, Cyprus
    Lancet 360:1222-4. 2002
    Deletions of specific regions on the Y chromosome cause male infertility. Recent advances in infertility treatment allow Y chromosome deletions to be transmitted to male offspring with the assumption that there will be no clinical ..
  72. ncbi Chlamydia trachomatis and male infertility: chlamydia-IgA antibodies in seminal plasma are C. trachomatis specific and associated with an inflammatory response
    F R Ochsendorf
    Zentrum Dermatologie und Venerologie, Klinikum d J W Goethe Universität Frankfurt, Germany
    J Eur Acad Dermatol Venereol 12:143-52. 1999
    There is controversy over the role of asymptomatic genital tract infection by Chlamydia trachomatis, its optimal diagnosis, and its place in the etiology of male infertility.
  73. ncbi Chronic prostatitis and male accessory gland infection--is there an impact on male infertility (diagnosis and therapy)?
    K Everaert
    Department of Urology, Ghent University Hospital, Ghent, Belgium
    Andrologia 35:325-30. 2003
    ..was to discuss by means of a review of the literature and own study material the multifactorial aetiology of male infertility, extrapolate this hypothesis to male accessory gland infection (MAGI) and relate it to chronic prostatitis ..
  74. pmc Cytogenetic abnormalities in 179 cases with male infertility in Western Region of Turkey: report and review
    M Akgul
    Faculty of Medicine, Department of Medical Genetics, Ege University, Izmir, Turkey
    J Assist Reprod Genet 26:119-22. 2009
    ..In this study we aimed to evaluate the postnatally screened karyotype results in couples who were referred because of primary infertility between 2000 and 2006 in Izmir...
  75. ncbi Selected genetic factors associated with male infertility
    Trieu Huynh
    Monash Institute of Reproduction and Development, Centre for Early Human Development, Clayton, Victoria, Australia
    Hum Reprod Update 8:183-98. 2002
    ..spermatogonia undergo meiosis to become spermatozoa, have identified a number of genetic determinants of male infertility. Indeed, a more comprehensive knowledge of the genetic regulation of spermatogenesis has alleviated the ..
  76. ncbi Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization
    Alexander N Yatsenko
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 15:3411-9. 2006
    ..The genetic etiologies of idiopathic male infertility are unknown, partly due to lack of simple diagnostic techniques...
  77. ncbi The role of heat shock protein 70 (Hsp 70) in male infertility: is it a line of defense against sperm DNA fragmentation?
    Gül Ozdemirler Erata
    Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, Capa, Istanbul, Turkey
    Fertil Steril 90:322-7. 2008
    To clarify the role of heat shock protein 70 (Hsp 70) and its relation with DNA damage in male infertility.
  78. ncbi Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
    Klaus Dieterich
    Centre Hospitalier Universitaire CHU de Grenoble, Département de Génétique et Procréation, Unite Fonctionelle UF de biochimie génétique et moléculaire, F 38700 La Tronche, France
    Nat Genet 39:661-5. 2007
    ..We conclude that the absence of AURKC causes male infertility owing to the production of large-headed multiflagellar polyploid spermatozoa.
  79. ncbi Lycopene therapy in idiopathic male infertility--a preliminary report
    Narmada P Gupta
    Department of Urology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India
    Int Urol Nephrol 34:369-72. 2002
    ..of reactive oxygen species (ROS) containing free oxygen radicals has been identified as one of the causes of male infertility. Lycopene is a component of human redox defence mechanism against free radicals...
  80. ncbi Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity
    A Zini
    Division of Urology, Department of Surgery, St Mary s Hospital, McGill University, 3830 Lacombe Avenue, Montreal, Quebec, H3T 1M5
    Hum Reprod 20:1018-21. 2005
    ..The objective of this study was to examine the effect of varicocelectomy on sperm DNA denaturation (DD, an index of sperm DNA damage) in infertile men with a clinical varicocele...
  81. ncbi Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters
    Mohammad Reza Safarinejad
    J Steroid Biochem Mol Biol 122:193-203. 2010
    b>Male infertility is a multifactorial condition with a strong genetic component. In the last decade a large number of investigations focused on the identification of gene variants affecting spermatogenesis in human...
  82. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..Future experiments are required to determine the role of ERbeta in bone and cardiovascular homeostasis...
  83. ncbi A rapidly evolving homeobox at the site of a hybrid sterility gene
    C T Ting
    Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
    Science 282:1501-4. 1998
    ..Such rapid sequence divergence is driven by positive selection and may contribute to reproductive isolation...
  84. ncbi Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysis
    Ave Kris Lend
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Syst Biol Reprod Med 56:84-90. 2010
    ..In conclusion, we suggest that FSHR haplotypes are not considerable risk factors for spermatogenic failure. The protective nature of G-29-A919-A2039 haplotype cannot be concluded without additional studies...
  85. pmc Sperm chromatin proteomics identifies evolutionarily conserved fertility factors
    Diana S Chu
    Department of Biology, 1600 Holloway Avenue, San Francisco State University, San Francisco, California 94132, USA
    Nature 443:101-5. 2006
    b>Male infertility is a long-standing enigma of significant medical concern...
  86. pmc Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility
    Huili Zheng
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 104:6852-7. 2007
    ..Our study reveals that proper cytoplasm removal is a genetically regulated process requiring the participation of Spem1 and that lack of Spem1 causes sperm deformation and male infertility.
  87. ncbi Cytokine concentrations in seminal plasma from subfertile men are not indicative of the presence of Ureaplasma urealyticum or Mycoplasma hominis in the lower genital tract
    Y Pannekoek
    Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
    J Med Microbiol 49:697-700. 2000
    ..These data strongly indicate that the presence of U. urealyticum or M. hominis in the lower genital tract of subfertile males reflects a silent colonisation rather than infection...
  88. ncbi Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in mice
    Si Tse Jiang
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Hum Mol Genet 17:3368-79. 2008
    ..The possible roles of nephrocystin in the formation and maintenance of Sertoli-spermatid junctions are still under investigation...
  89. ncbi Varicocelectomy reduces reactive oxygen species levels and increases antioxidant activity of seminal plasma from infertile men with varicocele
    T Mostafa
    Department of Andrology, Faculty of Medicine, Cairo University, 14 Wadi El-Neel Street, Mohandesin, Cairo, Egypt
    Int J Androl 24:261-5. 2001
    ..A further significant decrease took place during the following 3 months. It is concluded that varicocelectomy reduces ROS levels and increases antioxidant activity of seminal plasma from infertile men with varicocele...
  90. ncbi Follicle-stimulating hormone-independent functions of primate Sertoli cells: potential implications in the diagnosis and management of male infertility
    Yendrembam Sangeeta Devi
    Division of Cellular Endocrinology, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    J Clin Endocrinol Metab 91:1062-8. 2006
    ..The role of FSH in regulation of lactate and estradiol production by primate Sc is currently unknown...
  91. ncbi Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on spermatogenesis and expression of p53 protein in male infertility
    Koji Shiraishi
    Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Urol 178:1012-7; discussion 1017. 2007
    Oxidative stress is involved in male infertility. However, little is known about how it impairs spermatogenesis...
  92. ncbi Lipid peroxidation and antioxidant enzymes in male infertility
    S P Dandekar
    Department of Biochemistry, Seth G S Medical College, Parel, Mumbai 400 012, India
    J Postgrad Med 48:186-89; discussion 189-90. 2002
    ..The aim was to study lipid peroxidation and antioxidant enzymes such as catalase, glutathione peroxidase and superoxide dismutase (SOD) and to correlate the same, with the 'water test', in male infertility.
  93. pmc Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes
    Fengyun Sun
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:1699-707. 2010
    ..Thus, EIF4G3 is required for HSPA2 translation in spermatocytes, a finding that provides the first genetic evidence for selective translational control of meiotic exit in mammalian spermatocytes...
  94. ncbi Oxidative stress and male infertility: from research bench to clinical practice
    Ramadan A Saleh
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Androl 23:737-52. 2002
  95. ncbi Microsurgical management of male infertility
    Marc Goldstein
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Nat Clin Pract Urol 3:381-91. 2006
    The introduction of microsurgical techniques has revolutionized the treatment of male infertility. As a result of technical advances and innovation over the past 10-15 years, previously infertile couples are now able to conceive naturally ..
  96. pmc Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6
    Rossana Sapiro
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 22:6298-305. 2002
    ..The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia...
  97. pmc Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility
    Atefeh Borghei
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 281:9423-31. 2006
    ..These data strongly suggest that tyrosine sulfation of unidentified substrate(s) play a crucial role in these processes and document for the first time the critical importance of post-translational tyrosine sulfation in male fertility...
  98. ncbi Varicocele is associated with abnormal retention of cytoplasmic droplets by human spermatozoa
    A Zini
    Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Fertil Steril 74:461-4. 2000
    ..To determine whether varicocele is associated with retention of sperm cytoplasmic droplets in infertile men...
  99. ncbi Association of genetic markers within the KIT and KITLG genes with human male infertility
    J J Galan
    Department of Structural Genomics, Neocodex SL, Sevilla, Spain
    Hum Reprod 21:3185-92. 2006
    ..Animal models and functional studies in humans suggest that this signalling pathway plays a role in male infertility.
  100. pmc Histone demethylase JHDM2A is involved in male infertility and obesity
    Yuki Okada
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Androl 31:75-8. 2010
    ..Thus, JHDM2A possesses organ/tissue-specific target genes, and impairment of this molecule cannot be compensated by other JmjC-containing histone demethylases, suggesting the importance of this molecule in vivo...
  101. ncbi Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1
    A Poplinski
    Centre of Reproductive Medicine and Andrology, 48149 Munster, Germany
    Int J Androl 33:642-9. 2010
    ..We conclude that idiopathic male infertility is strongly associated with imprinting defects at IGF2/H19 ICR1 and MEST, with aberrant MEST methylation ..

Research Grants78

  1. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..lead to a better understanding the role of environmental toxins in paternal transmission of malformations and male infertility. If successful in completing these aims, we will have elucidated a novel major downstream effect of ..
  2. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..reproductive medicine, namely the lack of reliable, objective methodology for accurate diagnostics of human male infertility. Our goal is to validate the sperm-specific thioredoxin SPTRX3 as a novel biomarker of human sperm quality...
  3. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility.
  4. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    Clinton C MacDonald; Fiscal Year: 2013
    ..We discovered a gene, CSTF2T, that can be a hidden cause of male infertility-hidden, because females missing this gene have normal fertility, while males have severe problems in sperm ..
  5. Model of the Human Testis for Reproductive Toxicology
    PAUL JACOB TUREK; Fiscal Year: 2011
    ..toxins could help protect developing fetuses from unwanted toxic exposures, reduce the incidence of male infertility, potentially lower rates of testis cancer, and create safer drugs for the marketplace...
  6. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
    ..CFTR), a small conductance, cAMP activated chloride ion channel, leads to developmental defects that cause male infertility in humans...
  7. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..Accomplishment of these goals will lead to novel insights in clinical diagnosis of male infertility and provide tools for evaluating pharmacological contraceptive targets.
  8. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
    ..These studies may reveal the etiologies behind unexplained male infertility and lead to advanced diagnostic and therapeutic tools to better address and manage male infertility.
  9. The XXII nd North American Testis Workshop
    WILLIAM WALLACE WRIGHT; Fiscal Year: 2013
    ..this meeting is to promote solutions for two major medical and public health problems: the high incidence of male infertility in the developed world and the lack of a safe and reversible male contraceptive...
  10. Intratesticular Sex Steroids and Spermatogenesis in Man
    MARA YVONNE ROTH; Fiscal Year: 2013
    ..intratesticular hormonal physiology may then help to identify more effective and less invasive treatments for male infertility. The specific aims of this proposal are: 1) to define the minimum intratesticular testosterone concentration ..
  11. Structural Targeting Testis Specific Kinases (TSSK) 1 &2 for Male Contraception
    John C Herr; Fiscal Year: 2013
    ..Deletion of TSSK 1 &2 in mice causes male infertility, with arrest of spermiogenesis occurring during flagellogenesis...
  12. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..that is based on our understanding that germ cell DNA is subject to damage and may be an important factor in male infertility. A rapid, simple analytical method to assess the level of oxidative DNA damage in germ cells will be ..
  13. MOLECULAR BASIS OF MAMMALIAN SPERM MOTILITY
    Jerome F Strauss; Fiscal Year: 2010
    ..This knowledge will provide a molecular framework for understanding sperm motility defects causing male infertility and the function of "9+2" cilia in general...
  14. The MRAD9 Radioresistance Gene
    Howard B Lieberman; Fiscal Year: 2013
    ..impact on a wide array of important issues, including understanding inherent susceptibility to DNA damage, with implications for radiotherapy, as well as the genetic control of sperm development and male infertility.
  15. Role of Cyclin A's in mammalian gametogenesis
    Debra J Wolgemuth; Fiscal Year: 2013
    ..Our findings will enhance our understanding of the control of meiosis as it relates to male infertility, possibly suggest new targets for contraception, and provide critical insight into the unique properties of ..
  16. The Utility of Empiric Medical Treatment of Infertile Oligo-asthenospermic Men
    Peter R Casson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Male infertility is a common and devastating problem, and the prevalence is increasing, much of which is related to obesity...
  17. Regulation of Spermatocyte Transcription by Testis TAFS
    Margaret T Fuller; Fiscal Year: 2013
    ..mutations in the tTAFs cause meiosis I arrest and failure of spermatid differentiation, understanding their regulation and mode of action may illuminate mechanisms underlying the male infertility syndrome meiosis I maturation arrest.
  18. microRNA regulation of spermatogonial stem cell self-renewal and differentiation
    RALPH LAWRENCE BRINSTER; Fiscal Year: 2013
    ..mechanistic insight into the regulation of male fertility and is critical for future therapeutic treatment of male infertility in both animals and humans...
  19. Regulation of Leydig cell function by small noncoding RNAs
    Wei Yan; Fiscal Year: 2013
    ..Future investigation based upon this pilot study may lead to novel diagnostics and treatments for male infertility due to endocrine disorders, and miRNAs may represent a novel class of male contraceptive agents.
  20. Embryonic Development of the Mammalian Epididymis
    Barry T Hinton; Fiscal Year: 2013
    ..microenvironment that allows for sperm maturation and survival, and disruptions to this function lead to male infertility. However, disruptions to epididymal function may also arise as a consequence of abnormal fetal development, ..
  21. Evolutionary and Functional Genetics of Male Reproduction using Wild Mice as a Mo
    Matthew D Dean; Fiscal Year: 2013
    ..There is a high incidence of unexplained male infertility in humans, which can be a clinical sign that precedes many more devastating diseases, including prostate ..
  22. Cyclic AMP Action During Sperm Function
    George L Gerton; Fiscal Year: 2012
    ..When the Sacy gene is ablated by homologous recombination, the result is male infertility. Although spermatogenesis in the testis appears to proceed undisturbed, the morphologically normal sperm are ..
  23. Identification and Characterization of New Genes Required for Cilia Motility
    Jennifer R Panizzi; Fiscal Year: 2010
    ..individuals are estimated to have PCD, which typically manifests as chronic respiratory tract infection, male infertility, often some degree of situs reversal due to lost or impaired cilia motility, and in rare cases, cystic kidney ..
  24. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2013
    ..they transmit their findings to adjacent cells will help define the pathophysiological mechanisms underlying male infertility, and diseases of the lung, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis ..
  25. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2013
    ..AHRR polymorphisms have been linked to male infertility and endometriosis in women, and the AHRR has been proposed to function as a tumor suppressor gene...
  26. Characterization of male germline stem cells in a rhesus model of infertility
    Kyle E Orwig; Fiscal Year: 2012
    ..Responsible development of these ideas in the rhesus model may have implications for treating some cases of male infertility.
  27. Neuroendocrine-modulated epithelial HCO3- transport
    Bruce D Schultz; Fiscal Year: 2013
    ..Diseases of epithelial anion transport such as cystic fibrosis result in male infertility. We established protocols to study ion transport in the intact porcine vas deferens, in freshly isolated ..
  28. Genetic basis of sperm competition in Peromyscus
    Heidi S Fisher; Fiscal Year: 2010
    ..traits influenced by sperm competition, thereby expanding our understanding of reproductive biology and male infertility. Relevance: This research is of direct relevance to the mission of NIH because it will identify and ..
  29. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010
    ..CatSper1-deficient males will be examined in detail and the reason(s) for male infertility will be determined...
  30. Developing Male Contraceptives by Targeting ANT4
    Naohiro Terada; Fiscal Year: 2013
    ..Targeted depletion of Ant4 in mice results in male meiotic arrest and subsequent male infertility. Since exogenous inhibition of male meiosis is considered one of the best approaches to develop male ..
  31. Do we need Y chromosome for successful reproduction?
    Monika A Ward; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Male infertility affects 5-10% of the population...
  32. Transcriptome-wide Polyadenylation Site Use in Male Germ Cell Transcripts
    BECKY SARTINI; Fiscal Year: 2013
    ..of the molecular regulation of sperm production holds promise in identifying specific underlying causes of male infertility that can lead to more accurate tests, treatments and, in the case of germ-cell specific processes, also ..
  33. Mechanisms of Circadian Rhythmicity in CLOCK-Deficient Mice
    DAVID RAYMOND WEAVER; Fiscal Year: 2013
    ..Infertility affects ~ 10% of couples, with about half of this related to male infertility. Abnormal formation of bone-like substances in tissues that are normally not calcified (arthropathy) ..
  34. Regulation of spermatogenesis by sumoylation
    Margarita Vigodner; Fiscal Year: 2011
    ..proteins (SUMO) at the level of individual targets and corresponding pathways, leading to the better understanding of possible causes of male infertility and development of novel safe contraceptives, thus improving human healthcare.
  35. Functions of the BLM Helicase in Telomere Maintenance
    JOANNA LOUISE GRODEN; Fiscal Year: 2012
    ..known as Bloom's syndrome (BS), is characterized by sun-sensitivity, small stature, immunodeficiency, male infertility, and a tremendous predisposition to cancer of all sites and types...
  36. Reversal of Spermatogonial Arrest in Mice
    Gunapala Shetty; Fiscal Year: 2012
    ..reverse them in experimental animal models could apply to treatment of genetically or environmentally caused male infertility in humans...
  37. Penn Center for Study of Epigenetics in Reproduction
    Marisa S Bartolomei; Fiscal Year: 2013
    ..in Reproduction) will elucidate epigenetic mechanisms that govern male and female reproduction, contribute to male infertility and impact development of human and mouse embryos and extra-embryonic tissues...
  38. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Yolanda R Smith; Fiscal Year: 2013
    ..The University also provided leadership in the evaluation and treatment of male infertility, recruited and mentored a Clinical Research/Reproductive Scientist Training (CREST) scholar to develop a ..
  39. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR-SOLER; Fiscal Year: 2013
    ..of proton secretion in the urogenital tract and lead to better treatments for severe metabolic acidosis and male infertility. V-ATPase activity is likely orchestrated by a number of regulatory mechanisms;direct V-ATPase ..
  40. Regulation of chromosome synapsis in mice
    Peijing Jeremy Wang; Fiscal Year: 2013
    ..Completion of this project will provide insight into the etiology of male infertility and birth defects in humans.
  41. AMERICAN SOCIETY OF ANDROLOGY ANNUAL MEETING
    Dolores J Lamb; Fiscal Year: 2010
    ..involved in male reproduction (with applications in toxicology, contraceptive development, and treatment of male infertility), the endocrine bases for fertility and infertility, including early exposure to anti-androgens in the ..
  42. Transcriptional regulatory networks in spermatogonial stem cells
    BRIAN PETER HERMANN; Fiscal Year: 2013
    ..contributions to the understanding of SSCs and spermatogenesis, and develop new approaches for treating male infertility. Three immediate objectives to promote the transition to independence are addressed by the career development ..
  43. RNA Editing in the Neonatal and Adult Testis
    Elizabeth M Snyder; Fiscal Year: 2013
    ..Previous work has demonstrated that global ablation of a putative RNA editing regulator results in male infertility due to defects in post-meiotic germ cells...
  44. Functions of TEX11 and its associated proteins in mice and humans
    Peijing Jeremy Wang; Fiscal Year: 2013
    ..it is clear that new concepts and innovative approaches are required to evaluate genetic causes of human male infertility. The current application is to investigate the role of TEX11, an X chromosome-encoded factor, in regulating ..
  45. Regulation of Spermatogenesis by X-linked miRNAs
    Wei Yan; Fiscal Year: 2013
    ..and genetic mechanisms by which sperm are produced is critically important for diagnosis and treatment of male infertility, as well as for the development of non-hormonal male-specific contraceptives...
  46. Identification of Tyrosine-Sulfated Proteins in the Male Genital Tract
    Kevin L Moore; Fiscal Year: 2012
    ..The male infertility phenotype is characterized by normal spermatogenesis, but abnormal sperm function...
  47. Minimum Y gene complement necessary for successful ART
    MONIKA WARD; Fiscal Year: 2009
    ..The application also has significance for those utilizing ART to treat male infertility.
  48. The Mechanism of Pericentriolar Material Assembly During Centrosome Biogenesis
    Tomer Avidor-Reiss; Fiscal Year: 2013
    ..Defective centrosome biogenesis causes male infertility, numerous types of cancer, and various developmental disorders...
  49. Genetic Basis of Oligozoospermia in Infertile Males
    Alexander N Yatsenko; Fiscal Year: 2013
    ..long-term objective is to become an independent physician- scientist focused on studying the genetic bases of male infertility that affects the reproductive health of men...
  50. Triplex-based Aptamers to Detect DNA Damage
    Paul S Miller; Fiscal Year: 2010
    ..biological consequences and may be involved in processes that affect human health, including aging and male infertility. Simple methods to detect these lesions could provide useful diagnostic or prognostic tools for evaluating ..
  51. TRANSLATIONAL CONTROL DURING MURINE SPERMATOGENESIS
    Robert E Braun; Fiscal Year: 2010
    ..The knowledge gained from these studies may be useful in the genetic assessment of male infertility in humans, and lead to the development of male contraceptives designed to disrupt essential regulatory steps ..
  52. Role of VEGF in Testis Morphogenesis
    Andrea S Cupp; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In the past 10 years, the incidence of male infertility cases has increased at an alarming rate resulting in development of a new syndrome- Testicular Dysgenesis Syndrome...
  53. Functions of MOV10L1 in piRNA biogenesis and germ cell development
    Peijing Jeremy Wang; Fiscal Year: 2013
    ..These studies will provide insight into etiology, diagnosis, and prevention of human diseases including male infertility and birth defects.
  54. Male Reproductive Health Research Career Development Program
    Peter R Carroll; Fiscal Year: 2010
    ..these include developmental and stem cell biology and genetics, steroidogenesis, sexual function and health, male infertility, infertility outcomes research using broad and ethnically diverse databases of reproductive age men, ..
  55. An in vitro system for the study of epithelial bicarbonate secretion
    Jonathan D Kaunitz; Fiscal Year: 2010
    ..cystic fibrosis, can cause severe problems such as lung disease, pancreatitis, intestinal obstruction, and male infertility. Study of the mechanism of bicarbonate secretion has been hampered by the lack of a suitable model other than ..
  56. Investigations of Mouse Interspecies Hybrids
    James M McGrath; Fiscal Year: 2013
    ..We have chosen to use Mus musculus: caroli or spretus hybrids and assess them for viability, male infertility and somatic growth/obesity...
  57. COLORADO REPRODUCTIVE MEDICINE UNIT
    Ruben Alvero; Fiscal Year: 2013
    ..A gap in knowledge exists as no clinical trials have been conducted to address treatments for obesity-related male Infertility. Use of aromatase inhibitors in men leads to improvement of compromised sperm parameters and reproductive ..
  58. EPIGENETIC TRANSGENERATIONAL ENDOCRINE DISRUPTOR ACTIONS
    Michael K Skinner; Fiscal Year: 2013
    ..reprogramming of the male germline that then induces transgenerational adult onset disease states of male infertility, prostate disease, kidney disease, immune abnormalities and tumor development...
  59. A Testis Specific Regulatory Subunit of Protein Phosphatase-1
    Ann O Sperry; Fiscal Year: 2010
    ..of a testis-specific regulatory protein in sperm formation and therefore will advance possible remedies for male infertility as well as new strategies for contraceptive design...
  60. Understanding genetics of spermatogenic failure by resequencing the sex chromosome
    RENEE GEORGE; Fiscal Year: 2013
    ..is extremely complex and a disruption at any stage can result in spermatogenic failure-a leading cause of male infertility tha affects roughly 1 in 100 men worldwide...
  61. Selective Translational Regulation of Male Fertility
    Mary Ann Handel; Fiscal Year: 2013
    ..The male infertility phenotype of Eif4g3 mutant mice provides compelling evidence for the crucial importance of translational ..
  62. Epigenetic Defects in Human Spermatozoa: Biomarker of Infertility and Sperm Toxic
    REBECCA Z contact SOKOL; Fiscal Year: 2010
    ..For most male infertility cases, the etiology is unknown and specific therapy is not available...
  63. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
    ..together a meeting in which leaders in research on diseases such as PKD, Situs Inversus, Hydrocephalus and male infertility can meet with others researching the biochemistry, structure, and assembly of cilia and flagella...
  64. Cisplatin and Mechanisms of Long-term Male Infertility
    JOHN RICHBURG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  65. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..CAH patients still manifest the adverse effects (compromised final height, polycystic ovarian disease, male infertility, etc.) of elevated androgens/estrogens...
  66. New Mouse Mutation Exhibiting Failed Fertilization
    Mary Ann Handel; Fiscal Year: 2006
    ..Understanding causes of male infertility will likely aid in identification of suitable contraceptive targets...
  67. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    DESCRIPTION: Varicocele-associated human male infertility (VAI) represents greater then 20 percent of male infertility in the US. Surgical repair of varicocele restores fertility only 1/3 of time...
  68. BIOCHEMICAL MARKERS OF SPERM FERTILITY
    Gabor Huszar; Fiscal Year: 1999
    he central theme of our research is idiopathic or unexplained male infertility which affects about 1.5 million American men. For the present proposal we have identified a fertIle control population...
  69. PORTABILITY OF BIOCHEMICAL MARKERS OF SPERM MATURITY
    Gabor Huszar; Fiscal Year: 2001
    ..translation and the single sperm DNA comet assay, which highlight sperm DNA fragmentation, a known cause of male infertility and increased rates of pregnancy loss...
  70. MALE INFERTILITY: SPERM MOTILITY AND AXONEMAL STABILITY
    REGINA TURNER; Fiscal Year: 2001
    ..In animals, male infertility can be economically devastating when it occurs in a genetically valuable individual...
  71. CENTROSOME DEFECTS AS CAUSES OF MALE INFERTILITY
    Gerald Schatten; Fiscal Year: 1999
    ..investigates the microtubule organizing capacity of the human sperm centrosome as causes of idiopathic male infertility . Eighteen questions are posed in four specific aims using sperm from fertile and infertile men...
  72. CELL-CELL INTERACTIONS IN TESTIS DEVELOPMENT
    Michael Skinner; Fiscal Year: 2007
    ..Abnormal testis development and male infertility may in part be due to inappropriate control of testicular cell growth and differentiation during development...
  73. ALTERNATIVE MRNA PROCESSING DURING SPERMATOGENESIS
    PETER CHALLONER; Fiscal Year: 1992
    ..in the trans- acting factors involved in alternative pre-MRNA processing in spermatids may be one source of male infertility. In addition, these defects could produce anomalous transcripts from cellular proto-oncogenes, causing the ..
  74. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..by current somatic cell apoptosis mechanisms, this prompted our hypothesis that lead exposures produce male infertility by altering calcium homeostatsis, and a related detailed mechanism of lead action...
  75. ANALYSIS OF THE ROLE OF GCNF IN SPERMATOGENESIS
    Austin Cooney; Fiscal Year: 1999
    Male idiopathic sterility is the form of male infertility about which least is known because it is due to multiple causes. Generally, affected males display gross or subtle abnormalities in sperm function...
  76. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2009
    ..Ablation of sAC in mice produces complete male infertility and major disruption in sperm motility...
  77. Role of Y chromosomal genes in male fertility
    Alexander I Agoulnik; Fiscal Year: 2010
    ..The most frequent cause of etiopathogenetic male infertility revealed by molecular genetic techniques is a deletion of the Y chromosome...
  78. PURIFIED TESTIS ANTIGENS AND TESTICULAR AUTOIMMUNITY
    Kenneth Tung; Fiscal Year: 1991
    ..to clarify the pathogenesis of murine EAO as model of organ-specific auto-immune disease, as a cause of male infertility, and as a mew approach to study Sertoli cell biology...