Genomes and Genes
Summary: Diminished or absent ability of the male to effect conception.
Publications287 found, 100 shown here
- The mouse Spo11 gene is required for meiotic chromosome synapsisP J Romanienko
Genetics and Biochemistry Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 20892, Bethesda, MD, USA
Mol Cell 6:975-87. 2000..We speculate that there is an additional role for Spo11, after it generates DSBs, in synapsis...
- Oxidative stress and male infertility--a clinical perspectiveKelton Tremellen
Repromed, 180 Fullarton Road, Dulwich, 5065 Adelaide, South Australia, Australia
Hum Reprod Update 14:243-58. 2008..Finally, the review will outline methods available for diagnosing oxidative stress and the various treatments available...
- Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overS M Baker
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
Nat Genet 13:336-42. 1996..We also show that Mlh1 appears to localize to sites of crossing over on meiotic chromosomes. Together these findings suggest that Mlh1 is involved in DNA mismatch repair and meiotic crossing over...
- Mitochondria-related male infertilityKazuto Nakada
Graduate School of Life and Environmental Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8572, Japan
Proc Natl Acad Sci U S A 103:15148-53. 2006..patients with fertility problems, there is a possibility that mitochondrial respiration defects contribute to male infertility. To address this possibility, we used a transmitochondrial mouse model (mito-mice) carrying wild-type mtDNA ..
- Men at risk: occupation and male infertilityPaul Claman
Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Ottawa Faculty of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
Fertil Steril 81:19-26; quiz 57-60. 2004There is accumulating evidence that workplace exposure to toxic substances contributes to male infertility. Men suffering from infertility problems may do well to look at their occupations, where exposure to certain substances may be a ..
- Meiotic sex chromosome inactivationJames M A Turner
Division of Stem Cell Biology and Developmental Genetics, MRC NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 134:1823-31. 2007..Furthermore, failure in MSCI is emerging as an important etiological factor in meiotic sterility...
- miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesisWei Deng
Department of Cell Biology, Duke University Medical Center, P O Box 3709, DUMC, Durham, NC 27710, USA
Dev Cell 2:819-30. 2002..Whereas MIWI and CREM do not regulate each other's expression, MIWI complexes with mRNAs of ACT and CREM target genes. Hence, MIWI may control spermiogenesis by regulating the stability of these mRNAs...
- Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicoceleRamadan A Saleh
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Fertil Steril 80:1431-6. 2003..To examine levels of sperm DNA damage and oxidative stress (OS) in infertile men with varicocele...
- The effect of obesity on sperm disorders and male infertilityStefan S du Plessis
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
Nat Rev Urol 7:153-61. 2010..Several mechanisms might account for the effect of obesity on male infertility, both directly and indirectly, by inducing sleep apnea, alterations in hormonal profiles (reduced inhibin B ..
- Oxidative stress & male infertilityKartikeya Makker
Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obsterics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Indian J Med Res 129:357-67. 2009..Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a ..
- EAU guidelines on male infertilityG R Dohle
Department of Urology, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Eur Urol 48:703-11. 2005
- Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'Claire L Borg
Department of Anatomy and Developmental Biology, The School of Biomedical Sciences, Monash University, Clayton 3800, Australia
Hum Reprod Update 16:205-24. 2010..A breakdown at any of these phases can result in male infertility. The production of mutant mouse models often yields an unexpected male infertility phenotype...
- Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraceptionMargarida Fardilha
Signal Transduction Laboratory, Center for Cell Biology, University of Aveiro, 3810 193 Aveiro, Portugal
Ann N Y Acad Sci 1030:468-78. 2004..alternatively spliced proteins as targets for the development of novel therapeutic strategies for male infertility and contraception is discussed...
- Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermiaGuntram Bezold
Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Fertil Steril 87:1087-97. 2007..the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers, and ..
- Eurycoma longifolia Jack in managing idiopathic male infertilityMohd Ismail Bin Mohd Tambi
Wellmen Clinic, Damai Service Hospital, Kuala Lumpur 52100, Malaysia
Asian J Androl 12:376-80. 2010..The proprietary extract of Eurycoma longifolia Jack significantly improved the sperm quality in these patients, allowing for 11 (14.7%) spontaneous pregnancies...
- Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertilityJinu Lee
Department of Pharmacology, CHA Stem Cell Institute, School of Medicine, CHA University, Bundang gu, Seongnam si, Kyunggi Do, Korea
J Cell Mol Med 13:1942-51. 2009..A male infertility-associated single nucleotide polymorphism (-9C > T) within the 5' untranslated region (5'UTR) of the ..
- Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approachAshok Agarwal
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
BJU Int 95:503-7. 2005
- Pathophysiology of varicoceles in male infertilityC K Naughton
Center for Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Ohio 44195, USA
Hum Reprod Update 7:473-81. 2001Varicoceles are found in 19 to 41% of infertile men, and is one treatable form of male infertility. The mechanism by which varicoceles cause the variable effect on male infertility and spermatogenesis is still unknown...
- Oxidative stress, DNA damage and the Y chromosomeR J Aitken
School of Biological and Chemical Sciences, Centre for Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 23008, Australia
Reproduction 122:497-506. 2001Recent advances in understanding of male infertility have implicated two major causative factors, oxidative stress and Y chromosome deletions...
- The Y deletion gr/gr and susceptibility to testicular germ cell tumorKatherine L Nathanson
Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Hum Genet 77:1034-43. 2005..In epidemiological studies, male infertility has shown an association with TGCT that is out of proportion with what can be explained by tumor effects...
- Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysisMarcello Cocuzza
Reproductive Research Center, Glickman Urological and Kidney Institute, Department of Obstetrics Gynecology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Int Braz J Urol 33:603-21. 2007..Thus evaluation of seminal ROS levels and extent of sperm DNA damage especially in an infertile male may help develop new therapeutic strategies and improve success of assisted reproductive techniques (ART)...
- CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populationsKumarasamy Thangaraj
Centre for Cellular and Molecular Biology, Hyderabad, India
J Androl 23:815-8. 2002CAG repeat expansion in exon 1 of the androgen receptor (AR) gene has been reported to be associated with male infertility in some but not all populations...
- Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniquesDonald P Evenson
Olson Biochemistry Laboratories, South Dakota State University, Brookings 57006, USA
J Androl 23:25-43. 2002
- Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout miceDerek Paisley
Molecular Medicine Centre, University of Edinburgh, Edinburgh, Scotland
Am J Pathol 164:2279-88. 2004..Therefore we found no evidence that Dpl compensates for the loss of PrP function in mutant mouse lines, but it does have an important anti-oxidant function necessary for sperm integrity and male fertility...
- Human sperm superoxide anion generation and correlation with semen quality in patients with male infertilityTamer M Said
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, OH 44195, USA
Fertil Steril 82:871-7. 2004..generation in infertile men and determine whether sperm quality is correlated with levels of ROS triggered by the exogenous reduced form of beta nicotinamide adenine dinucleotide phosphate (NADPH)...
- The present and future state of hormonal treatment for male infertilityPeter Y Liu
Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, New South Wales, Australia
Hum Reprod Update 9:9-23. 2003..One uncommon but treatable cause of male infertility is gonadotrophin deficiency in which gonadotrophin replacement therapy is highly effective at inducing ..
- Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trialF H Comhaire
Ghent University Hospital, Department of Medical and Urological Andrology, 9k12 IE, De Pintelaan, 185, B 9000, Gent, Belgium
Asian J Androl 7:257-62. 2005To evaluate the treatment of male infertility with a strong natural antioxidant, in addition to conventional treatment.
- Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadismDarius A Paduch
Department of Urology, Weill Medical College of Cornell University, 525 East 68th Street, Box 580, New York, NY 10021, USA
Reprod Biomed Online 10:747-54. 2005..The USP26 gene may be of importance in male reproduction. Mutations in this gene may be associated with male infertility, and may negatively affect testicular function.
- Protamines and male infertilityRafael Oliva
Human Genetics Laboratory, Genetics Unit, Department of Ciències Fisiològiques I, Faculty of Medicine, University of Barcelona and Hospital Clínic, IDIBAPS, Casanova 143, 08036 Barcelona, Spain
Hum Reprod Update 12:417-35. 2006..The present work reviews the articles published to date on the relationship between protamines and infertility...
- Contribution of environmental factors to the risk of male infertilityA Oliva
Unidad de Andrologia, Hospital Italiano Garibaldi, 2000 Rosario, Argentina
Hum Reprod 16:1768-76. 2001..CONCLUSION: We have shown that environmental factors contribute to the severity of infertility, and that this may worsen the effects of pre-existing genetic or medical risk factors...
- Best practice policies for male infertilityIra D Sharlip
Pan Pacific Urology, University of California, California, San Francisco, USA
Fertil Steril 77:873-82. 2002
- Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertilityD J Dix
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Proc Natl Acad Sci U S A 93:3264-8. 1996..These results suggest that HSP70-2 participates in synaptonemal complex function during meiosis in male germ cells and is linked to mechanisms that inhibit apoptosis...
- Expression failure of the Notch signaling system is associated with the pathogenesis of maturation arrest in male infertility patientsTetsuo Hayashi
Fertil Steril 81:697-9. 2004..The receptor or ligand of the Notch signaling system fails to express in the germ cells of maturation arrest patients, indicating that this signaling system is associated with for the pathogenesis of maturation arrest...
- Female subfertilityJohannes L H Evers
Department of Obstetrics and Gynaecology, Research Institute GROW, Academisch Ziekenhuis Maastricht, and Maastricht University, Maastricht, Netherlands
Lancet 360:151-9. 2002..has sufficient exposure to the chance of conception taken place? Are cost-effective, safe, and reliable treatments available for the disorder diagnosed? And, should the couple be referred straightaway for assisted reproduction?..
- Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertilityJie Zhang
Department of Anatomy, Histology and Embryology, Medical College of Xi an Jiaotong University, Xi an 710061, China
Asian J Androl 9:809-14. 2007To study the incidence of single nucleotide polymorphisms in ubiquitin-specific protease 26 (USP26) gene and its involvement in idiopathic male infertility in China.
- Chronic orchitis: a neglected cause of male infertility?H C Schuppe
Centre of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
Andrologia 40:84-91. 2008..inflammatory reactions in the testis should not be neglected as an underlying cause or co-factor of male infertility. However, definitive diagnosis of chronic asymptomatic orchitis still requires testicular biopsy and ..
- Sperm DNA damage: importance in the era of assisted reproductionArmand Zini
Division of Urology, Department of Surgery, McGill University, and St Mary s Hospital, 3830 Lacombe Avenue, Montreal, Quebec, Canada
Curr Opin Urol 16:428-34. 2006..To date, these consequences are still largely unknown...
- Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiencyBingfang Xu
Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
Dev Biol 319:211-22. 2008....
- Male infertility: role of genetic backgroundAlberto Ferlin
University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
Reprod Biomed Online 14:734-45. 2007b>Male infertility represents one of the clearest examples of a complex disease with a substantial genetic basis...
- Origins and consequences of DNA damage in male germ cellsR John Aitken
ARC Centre of Excellence in Biotechnology and Development and Discipline of Biological Sciences, University of Newcastle, NSW 2308, Australia
Reprod Biomed Online 14:727-33. 2007..Ultimately, resolving the precise nature of the DNA lesions present in the spermatozoa of infertile men will be an important step towards uncovering the aetiology of this damage and developing strategies for its clinical management...
- Genetic dissection of mammalian fertility pathwaysMartin M Matzuk
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Nat Cell Biol 4:s41-9. 2002....
- Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertilityS Venkatesh
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
Indian J Med Res 129:127-37. 2009..mtDNA mutations are considered to be the major aetiological factors in a variety of human diseases including male infertility. Identification of novel mutations in mtDNA of infertile patients with supraphysiological levels of ROS are ..
- Sperm preparation for ARTRalf R Henkel
Department of Dermatology and Andrology, Justus Liebig University, Giessen, Gaffkystr, 14, Germany
Reprod Biol Endocrinol 1:108. 2003..The older method, by which the ejaculate is forcefully aspirated through a narrow-gauge needle, should be abandoned as it can severely damage spermatozoa, thus resulting in immotile sperm...
- Gene polymorphisms and male infertility--a meta-analysis and literature reviewFrank Tüttelmann
Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
Reprod Biomed Online 15:643-58. 2007Many genetic polymorphisms have been studied extensively to elucidate their role in the pathophysiology of male infertility. This article presents a review of the literature following a thorough search of PubMed, a compilation of meta-..
- Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house miceJeffrey M Good
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Evolution 62:50-65. 2008..These data build on previous studies of speciation in house mice and show that the genetic basis of hybrid male sterility is fairly complex, even at this early stage of divergence...
- The metabolic syndrome and male infertilitySanjay S Kasturi
Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave, Tarry16 703, Chicago, IL 60611, USA
J Androl 29:251-9. 2008..At the end of this manuscript, we propose a new MetS/male infertility paradigm...
- The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in miceDavid H Volle
INSERM U895, Centre Méditerranéen de Médecine Moléculaire, Hôpital L Archet 2, Nice, France
J Clin Invest 119:3752-64. 2009..Together, these data demonstrate that Nr0b2 plays a critical role in the pathophysiological changes induced by DES in the mouse testis...
- Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in miceClaus Rodemer
Universitat Heidelberg, Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
Hum Mol Genet 12:1881-95. 2003..The mutant mice revealed multiple abnormalities, such as male infertility, defects in eye development, cataract and optic nerve hypoplasia, some of which were also observed in RCDP...
- Genetics of human male infertilityJ Poongothai
Computational Engineering and Networking Department, Amrita Viswha Vidyapeetham, Ettimadai, Coimbatore 638107, Tamil Nadu, India
Singapore Med J 50:336-47. 2009..b>Male infertility is a multifactorial syndrome encompassing a wide variety of disorders...
- Spermatogenesis in a man with complete deletion of USP9YAlice Luddi
Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Italy
N Engl J Med 360:881-5. 2009..These results suggest that it may not be necessary to consider USP9Y when screening the Y chromosome of infertile or subfertile men for microdeletions...
- Partial AZFc deletions and duplications: clinical correlates in the Italian populationClaudia Giachini
Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
Hum Genet 124:399-410. 2008....
- Genomic instability in mice lacking histone H2AXArkady Celeste
Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Science 296:922-7. 2002..Thus, H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA...
- Sperm chromatin structure and male fertility: biological and clinical aspectsJ Erenpreiss
University of Lund, Fertility Centre, Malmo University Hospital, Malmo SE 205 02, Sweden
Asian J Androl 8:11-29. 2006..Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed...
- Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSIRobert D Oates
Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Boston, MA 02118, USA
Hum Reprod 17:2813-24. 2002..In this study, we have fully characterized 42 infertile men with a Y chromosome microdeletion strictly confined to the AZFc region, and we report on 18 children conceived through the use of ICSI...
- Oxidative stress and medical antioxidant treatment in male infertilityFrancesco M Lanzafame
Territorial Center of Andrology, AUSL 8, Syracuse, Italy
Reprod Biomed Online 19:638-59. 2009Oxidative stress (OS) has been recognized as one of the most important cause of male infertility. Despite the antioxidant activity of seminal plasma, epididymis and spermatozoa, OS damages sperm function and DNA integrity...
- Seminal tract infections: impact on male fertility and treatment optionsC Keck
Department of Obstetrics and Gynecology at the University, Freiburg, Germany
Hum Reprod Update 4:891-903. 1998Bacterial and viral infections of the genital tract may be important aetiological factors for male infertility. Infectious processes may lead to deterioration of spermatogenesis, impairment of sperm function and/or obstruction of the ..
- Role of antioxidants in the treatment of male infertilityJohn C Kefer
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Int J Urol 16:449-57. 2009b>Male infertility continues to be a clinical challenge of increasing significance...
- Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1Anu Bashamboo
Human Developmental Genetics, Institut Pasteur, 75724 Paris, France
Am J Hum Genet 87:505-12. 2010..To test the hypothesis that mutations in NR5A1 cause male infertility, we sequenced NR5A1 in 315 men with idiopathic spermatogenic failure...
- PICK1 deficiency causes male infertility in mice by disrupting acrosome formationNan Xiao
Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
J Clin Invest 119:802-12. 2009..Our results suggest that PICK1 is involved in vesicle trafficking from the Golgi apparatus to the acrosome and cooperates with other proteins such as GOPC and CK2alpha' in acrosome biogenesis...
- Male infertility and the involvement of the X chromosomeKatrien Stouffs
Department of Embryology and Genetics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
Hum Reprod Update 15:623-37. 2009b>Male infertility is a worldwide problem, keeping many researchers puzzled. Besides environmental factors, much attention is paid to single gene defects...
- Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermiaAnika H D M Dam
Centre for Reproduction, Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Am J Hum Genet 81:813-20. 2007..This is the first example of a nonsyndromic male infertility condition in humans caused by an autosomal gene defect, and it could also mean that the identification of ..
- The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentationJose Luis Fernandez
Sección de Genética y Unidad de Investigación, Hospital Teresa Herrera, Complejo Hospitalario Juan Canalejo, La Coruna, Spain
J Androl 24:59-66. 2003..Therefore, the SCD test could potentially be used as a routine test for the screening of sperm DNA fragmentation in the andrology laboratory...
- Globozoospermia revisitedA H D M Dam
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Hum Reprod Update 13:63-75. 2007Globozoospermia is a rare (incidence <0.1%) but severe disorder in male infertility. Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa lacking an acrosome...
- Role of caspases in male infertilityTamer M Said
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A19 1, Cleveland, OH 44195, USA
Hum Reprod Update 10:39-51. 2004..In this review, we summarize the consequences of caspase activation, aiming to clarify their role in the pathogenesis of male infertility.
- The Y chromosome gr/gr subdeletion is associated with male infertilityM Lynch
Prince Henry s Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Victoria, Australia
Mol Hum Reprod 11:507-12. 2005..A total of 788 men from the Monash Male Infertility (MMI) database with a range of fertility disorders showed similar overall prevalences of AZFc (2...
- Role of sperm chromatin abnormalities and DNA damage in male infertilityA Agarwal
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Hum Reprod Update 9:331-45. 2003..Any form of sperm chromatin abnormalities or DNA damage may result in male infertility. In support of this conclusion, it was reported that in-vivo fecundity decreases progressively when > 30% ..
- Male infertility in cancer patients: Review of the literatureGert R Dohle
Department of Urology, Erasmus MC, Rotterdam, The Netherlands
Int J Urol 17:327-31. 2010....
- Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertilityM Ollero
Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Hum Reprod 16:1912-21. 2001..damage of membrane phospholipids and DNA in human spermatozoa has been implicated in the pathogenesis of male infertility. In this study, variations in ROS production, DNA structure (as measured by the sperm chromatin structure ..
- HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cellsLi yi Cai
Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa 214 8571, Japan
Reprod Toxicol 27:14-21. 2009..1 thymidine kinase (HSV1-TK)-introduced transgenic rodents and HSV-infected humans were reported to suffer male infertility. The present study aimed to find novel clues to clarify the cause of HSV1-TK-induced male infertility using ..
- Chlamydia trachomatis and male infertility in TunisiaR Gdoura
Laboratory of Bacteriology-Virology, University School of Medicine Sfax, Tunisia
Eur J Contracept Reprod Health Care 6:102-7. 2001..of infertile couples in Tunisia and to assess the relationship between chlamydial infection markers and male infertility. METHODS: Chlamydial DNA in urethral and in semen specimens was determined by using the Cobas Amplicor ..
- Effects of transmission of Y chromosome AZFc deletionsPhilippos C Patsalis
Cyprus Institute of Neurology and Genetics, Cyprus
Lancet 360:1222-4. 2002Deletions of specific regions on the Y chromosome cause male infertility. Recent advances in infertility treatment allow Y chromosome deletions to be transmitted to male offspring with the assumption that there will be no clinical ..
- Chlamydia trachomatis and male infertility: chlamydia-IgA antibodies in seminal plasma are C. trachomatis specific and associated with an inflammatory responseF R Ochsendorf
Zentrum Dermatologie und Venerologie, Klinikum d J W Goethe Universität Frankfurt, Germany
J Eur Acad Dermatol Venereol 12:143-52. 1999There is controversy over the role of asymptomatic genital tract infection by Chlamydia trachomatis, its optimal diagnosis, and its place in the etiology of male infertility.
- Chronic prostatitis and male accessory gland infection--is there an impact on male infertility (diagnosis and therapy)?K Everaert
Department of Urology, Ghent University Hospital, Ghent, Belgium
Andrologia 35:325-30. 2003..was to discuss by means of a review of the literature and own study material the multifactorial aetiology of male infertility, extrapolate this hypothesis to male accessory gland infection (MAGI) and relate it to chronic prostatitis ..
- Cytogenetic abnormalities in 179 cases with male infertility in Western Region of Turkey: report and reviewM Akgul
Faculty of Medicine, Department of Medical Genetics, Ege University, Izmir, Turkey
J Assist Reprod Genet 26:119-22. 2009..In this study we aimed to evaluate the postnatally screened karyotype results in couples who were referred because of primary infertility between 2000 and 2006 in Izmir...
- Selected genetic factors associated with male infertilityTrieu Huynh
Monash Institute of Reproduction and Development, Centre for Early Human Development, Clayton, Victoria, Australia
Hum Reprod Update 8:183-98. 2002..spermatogonia undergo meiosis to become spermatozoa, have identified a number of genetic determinants of male infertility. Indeed, a more comprehensive knowledge of the genetic regulation of spermatogenesis has alleviated the ..
- Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerizationAlexander N Yatsenko
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 15:3411-9. 2006..The genetic etiologies of idiopathic male infertility are unknown, partly due to lack of simple diagnostic techniques...
- The role of heat shock protein 70 (Hsp 70) in male infertility: is it a line of defense against sperm DNA fragmentation?Gül Ozdemirler Erata
Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, Capa, Istanbul, Turkey
Fertil Steril 90:322-7. 2008To clarify the role of heat shock protein 70 (Hsp 70) and its relation with DNA damage in male infertility.
- Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertilityKlaus Dieterich
Centre Hospitalier Universitaire CHU de Grenoble, Département de Génétique et Procréation, Unite Fonctionelle UF de biochimie génétique et moléculaire, F 38700 La Tronche, France
Nat Genet 39:661-5. 2007..We conclude that the absence of AURKC causes male infertility owing to the production of large-headed multiflagellar polyploid spermatozoa.
- Lycopene therapy in idiopathic male infertility--a preliminary reportNarmada P Gupta
Department of Urology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India
Int Urol Nephrol 34:369-72. 2002..of reactive oxygen species (ROS) containing free oxygen radicals has been identified as one of the causes of male infertility. Lycopene is a component of human redox defence mechanism against free radicals...
- Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrityA Zini
Division of Urology, Department of Surgery, St Mary s Hospital, McGill University, 3830 Lacombe Avenue, Montreal, Quebec, H3T 1M5
Hum Reprod 20:1018-21. 2005..The objective of this study was to examine the effect of varicocelectomy on sperm DNA denaturation (DD, an index of sperm DNA damage) in infertile men with a clinical varicocele...
- Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parametersMohammad Reza Safarinejad
J Steroid Biochem Mol Biol 122:193-203. 2010b>Male infertility is a multifactorial condition with a strong genetic component. In the last decade a large number of investigations focused on the identification of gene variants affecting spermatogenesis in human...
- Generation and reproductive phenotypes of mice lacking estrogen receptor betaJ H Krege
Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Proc Natl Acad Sci U S A 95:15677-82. 1998..Future experiments are required to determine the role of ERbeta in bone and cardiovascular homeostasis...
- A rapidly evolving homeobox at the site of a hybrid sterility geneC T Ting
Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
Science 282:1501-4. 1998..Such rapid sequence divergence is driven by positive selection and may contribute to reproductive isolation...
- Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysisAve Kris Lend
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Syst Biol Reprod Med 56:84-90. 2010..In conclusion, we suggest that FSHR haplotypes are not considerable risk factors for spermatogenic failure. The protective nature of G-29-A919-A2039 haplotype cannot be concluded without additional studies...
- Sperm chromatin proteomics identifies evolutionarily conserved fertility factorsDiana S Chu
Department of Biology, 1600 Holloway Avenue, San Francisco State University, San Francisco, California 94132, USA
Nature 443:101-5. 2006b>Male infertility is a long-standing enigma of significant medical concern...
- Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertilityHuili Zheng
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 104:6852-7. 2007..Our study reveals that proper cytoplasm removal is a genetically regulated process requiring the participation of Spem1 and that lack of Spem1 causes sperm deformation and male infertility.
- Cytokine concentrations in seminal plasma from subfertile men are not indicative of the presence of Ureaplasma urealyticum or Mycoplasma hominis in the lower genital tractY Pannekoek
Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
J Med Microbiol 49:697-700. 2000..These data strongly indicate that the presence of U. urealyticum or M. hominis in the lower genital tract of subfertile males reflects a silent colonisation rather than infection...
- Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in miceSi Tse Jiang
Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
Hum Mol Genet 17:3368-79. 2008..The possible roles of nephrocystin in the formation and maintenance of Sertoli-spermatid junctions are still under investigation...
- Varicocelectomy reduces reactive oxygen species levels and increases antioxidant activity of seminal plasma from infertile men with varicoceleT Mostafa
Department of Andrology, Faculty of Medicine, Cairo University, 14 Wadi El-Neel Street, Mohandesin, Cairo, Egypt
Int J Androl 24:261-5. 2001..A further significant decrease took place during the following 3 months. It is concluded that varicocelectomy reduces ROS levels and increases antioxidant activity of seminal plasma from infertile men with varicocele...
- Follicle-stimulating hormone-independent functions of primate Sertoli cells: potential implications in the diagnosis and management of male infertilityYendrembam Sangeeta Devi
Division of Cellular Endocrinology, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
J Clin Endocrinol Metab 91:1062-8. 2006..The role of FSH in regulation of lactate and estradiol production by primate Sc is currently unknown...
- Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on spermatogenesis and expression of p53 protein in male infertilityKoji Shiraishi
Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan
J Urol 178:1012-7; discussion 1017. 2007Oxidative stress is involved in male infertility. However, little is known about how it impairs spermatogenesis...
- Lipid peroxidation and antioxidant enzymes in male infertilityS P Dandekar
Department of Biochemistry, Seth G S Medical College, Parel, Mumbai 400 012, India
J Postgrad Med 48:186-89; discussion 189-90. 2002..The aim was to study lipid peroxidation and antioxidant enzymes such as catalase, glutathione peroxidase and superoxide dismutase (SOD) and to correlate the same, with the 'water test', in male infertility.
- Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytesFengyun Sun
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Development 137:1699-707. 2010..Thus, EIF4G3 is required for HSPA2 translation in spermatocytes, a finding that provides the first genetic evidence for selective translational control of meiotic exit in mammalian spermatocytes...
- Oxidative stress and male infertility: from research bench to clinical practiceRamadan A Saleh
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
J Androl 23:737-52. 2002
- Microsurgical management of male infertilityMarc Goldstein
Weill Medical College of Cornell University, New York, NY 10021, USA
Nat Clin Pract Urol 3:381-91. 2006The introduction of microsurgical techniques has revolutionized the treatment of male infertility. As a result of technical advances and innovation over the past 10-15 years, previously infertile couples are now able to conceive naturally ..
- Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6Rossana Sapiro
Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 22:6298-305. 2002..The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia...
- Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertilityAtefeh Borghei
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 281:9423-31. 2006..These data strongly suggest that tyrosine sulfation of unidentified substrate(s) play a crucial role in these processes and document for the first time the critical importance of post-translational tyrosine sulfation in male fertility...
- Varicocele is associated with abnormal retention of cytoplasmic droplets by human spermatozoaA Zini
Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Fertil Steril 74:461-4. 2000..To determine whether varicocele is associated with retention of sperm cytoplasmic droplets in infertile men...
- Association of genetic markers within the KIT and KITLG genes with human male infertilityJ J Galan
Department of Structural Genomics, Neocodex SL, Sevilla, Spain
Hum Reprod 21:3185-92. 2006..Animal models and functional studies in humans suggest that this signalling pathway plays a role in male infertility.
- Histone demethylase JHDM2A is involved in male infertility and obesityYuki Okada
Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Androl 31:75-8. 2010..Thus, JHDM2A possesses organ/tissue-specific target genes, and impairment of this molecule cannot be compensated by other JmjC-containing histone demethylases, suggesting the importance of this molecule in vivo...
- Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1A Poplinski
Centre of Reproductive Medicine and Andrology, 48149 Munster, Germany
Int J Androl 33:642-9. 2010..We conclude that idiopathic male infertility is strongly associated with imprinting defects at IGF2/H19 ICR1 and MEST, with aberrant MEST methylation ..
- THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTESKENAN RIFAT OMURTAG; Fiscal Year: 2013..lead to a better understanding the role of environmental toxins in paternal transmission of malformations and male infertility. If successful in completing these aims, we will have elucidated a novel major downstream effect of ..
- Validation of Novel Infertility BiomarkerPETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012..reproductive medicine, namely the lack of reliable, objective methodology for accurate diagnostics of human male infertility. Our goal is to validate the sperm-specific thioredoxin SPTRX3 as a novel biomarker of human sperm quality...
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2013..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility.
- MRNA PROCESSING IN REPRODUCTION AND FERTILIZATIONClinton C MacDonald; Fiscal Year: 2013..We discovered a gene, CSTF2T, that can be a hidden cause of male infertility-hidden, because females missing this gene have normal fertility, while males have severe problems in sperm ..
- Model of the Human Testis for Reproductive ToxicologyPAUL JACOB TUREK; Fiscal Year: 2011..toxins could help protect developing fetuses from unwanted toxic exposures, reduce the incidence of male infertility, potentially lower rates of testis cancer, and create safer drugs for the marketplace...
- Transcriptional Networks Regulating Luminal Environment in the EpididymisAnn Harris; Fiscal Year: 2013..CFTR), a small conductance, cAMP activated chloride ion channel, leads to developmental defects that cause male infertility in humans...
- Phosphorylation Events During Sperm CapacitationPABLO EDUARDO VISCONTI; Fiscal Year: 2013..Accomplishment of these goals will lead to novel insights in clinical diagnosis of male infertility and provide tools for evaluating pharmacological contraceptive targets.
- The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-RenewalEric Gustafson; Fiscal Year: 2013..These studies may reveal the etiologies behind unexplained male infertility and lead to advanced diagnostic and therapeutic tools to better address and manage male infertility.
- The XXII nd North American Testis WorkshopWILLIAM WALLACE WRIGHT; Fiscal Year: 2013..this meeting is to promote solutions for two major medical and public health problems: the high incidence of male infertility in the developed world and the lack of a safe and reversible male contraceptive...
- Intratesticular Sex Steroids and Spermatogenesis in ManMARA YVONNE ROTH; Fiscal Year: 2013..intratesticular hormonal physiology may then help to identify more effective and less invasive treatments for male infertility. The specific aims of this proposal are: 1) to define the minimum intratesticular testosterone concentration ..
- Structural Targeting Testis Specific Kinases (TSSK) 1 &2 for Male ContraceptionJohn C Herr; Fiscal Year: 2013..Deletion of TSSK 1 &2 in mice causes male infertility, with arrest of spermiogenesis occurring during flagellogenesis...
- Hormonal and Paracrine Regulation of SpermatogenesisBarry R Zirkin; Fiscal Year: 2010..that is based on our understanding that germ cell DNA is subject to damage and may be an important factor in male infertility. A rapid, simple analytical method to assess the level of oxidative DNA damage in germ cells will be ..
- MOLECULAR BASIS OF MAMMALIAN SPERM MOTILITYJerome F Strauss; Fiscal Year: 2010..This knowledge will provide a molecular framework for understanding sperm motility defects causing male infertility and the function of "9+2" cilia in general...
- The MRAD9 Radioresistance GeneHoward B Lieberman; Fiscal Year: 2013..impact on a wide array of important issues, including understanding inherent susceptibility to DNA damage, with implications for radiotherapy, as well as the genetic control of sperm development and male infertility.
- Role of Cyclin A's in mammalian gametogenesisDebra J Wolgemuth; Fiscal Year: 2013..Our findings will enhance our understanding of the control of meiosis as it relates to male infertility, possibly suggest new targets for contraception, and provide critical insight into the unique properties of ..
- The Utility of Empiric Medical Treatment of Infertile Oligo-asthenospermic MenPeter R Casson; Fiscal Year: 2013DESCRIPTION (provided by applicant): Male infertility is a common and devastating problem, and the prevalence is increasing, much of which is related to obesity...
- Regulation of Spermatocyte Transcription by Testis TAFSMargaret T Fuller; Fiscal Year: 2013..mutations in the tTAFs cause meiosis I arrest and failure of spermatid differentiation, understanding their regulation and mode of action may illuminate mechanisms underlying the male infertility syndrome meiosis I maturation arrest.
- microRNA regulation of spermatogonial stem cell self-renewal and differentiationRALPH LAWRENCE BRINSTER; Fiscal Year: 2013..mechanistic insight into the regulation of male fertility and is critical for future therapeutic treatment of male infertility in both animals and humans...
- Regulation of Leydig cell function by small noncoding RNAsWei Yan; Fiscal Year: 2013..Future investigation based upon this pilot study may lead to novel diagnostics and treatments for male infertility due to endocrine disorders, and miRNAs may represent a novel class of male contraceptive agents.
- Embryonic Development of the Mammalian EpididymisBarry T Hinton; Fiscal Year: 2013..microenvironment that allows for sperm maturation and survival, and disruptions to this function lead to male infertility. However, disruptions to epididymal function may also arise as a consequence of abnormal fetal development, ..
- Evolutionary and Functional Genetics of Male Reproduction using Wild Mice as a MoMatthew D Dean; Fiscal Year: 2013..There is a high incidence of unexplained male infertility in humans, which can be a clinical sign that precedes many more devastating diseases, including prostate ..
- Cyclic AMP Action During Sperm FunctionGeorge L Gerton; Fiscal Year: 2012..When the Sacy gene is ablated by homologous recombination, the result is male infertility. Although spermatogenesis in the testis appears to proceed undisturbed, the morphologically normal sperm are ..
- Identification and Characterization of New Genes Required for Cilia MotilityJennifer R Panizzi; Fiscal Year: 2010..individuals are estimated to have PCD, which typically manifests as chronic respiratory tract infection, male infertility, often some degree of situs reversal due to lost or impaired cilia motility, and in rare cases, cystic kidney ..
- 3-Dimensional modeling of basal cell function in pseudostratified epitheliaSylvie Breton; Fiscal Year: 2013..they transmit their findings to adjacent cells will help define the pathophysiological mechanisms underlying male infertility, and diseases of the lung, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis ..
- AHR signaling in Mammalian and Non-Mammalian ModelsMark E Hahn; Fiscal Year: 2013..AHRR polymorphisms have been linked to male infertility and endometriosis in women, and the AHRR has been proposed to function as a tumor suppressor gene...
- Characterization of male germline stem cells in a rhesus model of infertilityKyle E Orwig; Fiscal Year: 2012..Responsible development of these ideas in the rhesus model may have implications for treating some cases of male infertility.
- Neuroendocrine-modulated epithelial HCO3- transportBruce D Schultz; Fiscal Year: 2013..Diseases of epithelial anion transport such as cystic fibrosis result in male infertility. We established protocols to study ion transport in the intact porcine vas deferens, in freshly isolated ..
- Genetic basis of sperm competition in PeromyscusHeidi S Fisher; Fiscal Year: 2010..traits influenced by sperm competition, thereby expanding our understanding of reproductive biology and male infertility. Relevance: This research is of direct relevance to the mission of NIH because it will identify and ..
- Cyclic Nucleotide-Activated Calcium Channels in SpermDejian Ren; Fiscal Year: 2010..CatSper1-deficient males will be examined in detail and the reason(s) for male infertility will be determined...
- Developing Male Contraceptives by Targeting ANT4Naohiro Terada; Fiscal Year: 2013..Targeted depletion of Ant4 in mice results in male meiotic arrest and subsequent male infertility. Since exogenous inhibition of male meiosis is considered one of the best approaches to develop male ..
- Do we need Y chromosome for successful reproduction?Monika A Ward; Fiscal Year: 2013DESCRIPTION (provided by applicant): Male infertility affects 5-10% of the population...
- Transcriptome-wide Polyadenylation Site Use in Male Germ Cell TranscriptsBECKY SARTINI; Fiscal Year: 2013..of the molecular regulation of sperm production holds promise in identifying specific underlying causes of male infertility that can lead to more accurate tests, treatments and, in the case of germ-cell specific processes, also ..
- Mechanisms of Circadian Rhythmicity in CLOCK-Deficient MiceDAVID RAYMOND WEAVER; Fiscal Year: 2013..Infertility affects ~ 10% of couples, with about half of this related to male infertility. Abnormal formation of bone-like substances in tissues that are normally not calcified (arthropathy) ..
- Regulation of spermatogenesis by sumoylationMargarita Vigodner; Fiscal Year: 2011..proteins (SUMO) at the level of individual targets and corresponding pathways, leading to the better understanding of possible causes of male infertility and development of novel safe contraceptives, thus improving human healthcare.
- Functions of the BLM Helicase in Telomere MaintenanceJOANNA LOUISE GRODEN; Fiscal Year: 2012..known as Bloom's syndrome (BS), is characterized by sun-sensitivity, small stature, immunodeficiency, male infertility, and a tremendous predisposition to cancer of all sites and types...
- Reversal of Spermatogonial Arrest in MiceGunapala Shetty; Fiscal Year: 2012..reverse them in experimental animal models could apply to treatment of genetically or environmentally caused male infertility in humans...
- Penn Center for Study of Epigenetics in ReproductionMarisa S Bartolomei; Fiscal Year: 2013..in Reproduction) will elucidate epigenetic mechanisms that govern male and female reproduction, contribute to male infertility and impact development of human and mouse embryos and extra-embryonic tissues...
- COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKYolanda R Smith; Fiscal Year: 2013..The University also provided leadership in the evaluation and treatment of male infertility, recruited and mentored a Clinical Research/Reproductive Scientist Training (CREST) scholar to develop a ..
- Mechanisms of Kinase-dependent Regulation of the V-ATPase in KidneyNURIA M PASTOR-SOLER; Fiscal Year: 2013..of proton secretion in the urogenital tract and lead to better treatments for severe metabolic acidosis and male infertility. V-ATPase activity is likely orchestrated by a number of regulatory mechanisms;direct V-ATPase ..
- Regulation of chromosome synapsis in micePeijing Jeremy Wang; Fiscal Year: 2013..Completion of this project will provide insight into the etiology of male infertility and birth defects in humans.
- AMERICAN SOCIETY OF ANDROLOGY ANNUAL MEETINGDolores J Lamb; Fiscal Year: 2010..involved in male reproduction (with applications in toxicology, contraceptive development, and treatment of male infertility), the endocrine bases for fertility and infertility, including early exposure to anti-androgens in the ..
- Transcriptional regulatory networks in spermatogonial stem cellsBRIAN PETER HERMANN; Fiscal Year: 2013..contributions to the understanding of SSCs and spermatogenesis, and develop new approaches for treating male infertility. Three immediate objectives to promote the transition to independence are addressed by the career development ..
- RNA Editing in the Neonatal and Adult TestisElizabeth M Snyder; Fiscal Year: 2013..Previous work has demonstrated that global ablation of a putative RNA editing regulator results in male infertility due to defects in post-meiotic germ cells...
- Functions of TEX11 and its associated proteins in mice and humansPeijing Jeremy Wang; Fiscal Year: 2013..it is clear that new concepts and innovative approaches are required to evaluate genetic causes of human male infertility. The current application is to investigate the role of TEX11, an X chromosome-encoded factor, in regulating ..
- Regulation of Spermatogenesis by X-linked miRNAsWei Yan; Fiscal Year: 2013..and genetic mechanisms by which sperm are produced is critically important for diagnosis and treatment of male infertility, as well as for the development of non-hormonal male-specific contraceptives...
- Identification of Tyrosine-Sulfated Proteins in the Male Genital TractKevin L Moore; Fiscal Year: 2012..The male infertility phenotype is characterized by normal spermatogenesis, but abnormal sperm function...
- Minimum Y gene complement necessary for successful ARTMONIKA WARD; Fiscal Year: 2009..The application also has significance for those utilizing ART to treat male infertility.
- The Mechanism of Pericentriolar Material Assembly During Centrosome BiogenesisTomer Avidor-Reiss; Fiscal Year: 2013..Defective centrosome biogenesis causes male infertility, numerous types of cancer, and various developmental disorders...
- Genetic Basis of Oligozoospermia in Infertile MalesAlexander N Yatsenko; Fiscal Year: 2013..long-term objective is to become an independent physician- scientist focused on studying the genetic bases of male infertility that affects the reproductive health of men...
- Triplex-based Aptamers to Detect DNA DamagePaul S Miller; Fiscal Year: 2010..biological consequences and may be involved in processes that affect human health, including aging and male infertility. Simple methods to detect these lesions could provide useful diagnostic or prognostic tools for evaluating ..
- TRANSLATIONAL CONTROL DURING MURINE SPERMATOGENESISRobert E Braun; Fiscal Year: 2010..The knowledge gained from these studies may be useful in the genetic assessment of male infertility in humans, and lead to the development of male contraceptives designed to disrupt essential regulatory steps ..
- Role of VEGF in Testis MorphogenesisAndrea S Cupp; Fiscal Year: 2010DESCRIPTION (provided by applicant): In the past 10 years, the incidence of male infertility cases has increased at an alarming rate resulting in development of a new syndrome- Testicular Dysgenesis Syndrome...
- Functions of MOV10L1 in piRNA biogenesis and germ cell developmentPeijing Jeremy Wang; Fiscal Year: 2013..These studies will provide insight into etiology, diagnosis, and prevention of human diseases including male infertility and birth defects.
- Male Reproductive Health Research Career Development ProgramPeter R Carroll; Fiscal Year: 2010..these include developmental and stem cell biology and genetics, steroidogenesis, sexual function and health, male infertility, infertility outcomes research using broad and ethnically diverse databases of reproductive age men, ..
- An in vitro system for the study of epithelial bicarbonate secretionJonathan D Kaunitz; Fiscal Year: 2010..cystic fibrosis, can cause severe problems such as lung disease, pancreatitis, intestinal obstruction, and male infertility. Study of the mechanism of bicarbonate secretion has been hampered by the lack of a suitable model other than ..
- Investigations of Mouse Interspecies HybridsJames M McGrath; Fiscal Year: 2013..We have chosen to use Mus musculus: caroli or spretus hybrids and assess them for viability, male infertility and somatic growth/obesity...
- COLORADO REPRODUCTIVE MEDICINE UNITRuben Alvero; Fiscal Year: 2013..A gap in knowledge exists as no clinical trials have been conducted to address treatments for obesity-related male Infertility. Use of aromatase inhibitors in men leads to improvement of compromised sperm parameters and reproductive ..
- EPIGENETIC TRANSGENERATIONAL ENDOCRINE DISRUPTOR ACTIONSMichael K Skinner; Fiscal Year: 2013..reprogramming of the male germline that then induces transgenerational adult onset disease states of male infertility, prostate disease, kidney disease, immune abnormalities and tumor development...
- A Testis Specific Regulatory Subunit of Protein Phosphatase-1Ann O Sperry; Fiscal Year: 2010..of a testis-specific regulatory protein in sperm formation and therefore will advance possible remedies for male infertility as well as new strategies for contraceptive design...
- Understanding genetics of spermatogenic failure by resequencing the sex chromosomeRENEE GEORGE; Fiscal Year: 2013..is extremely complex and a disruption at any stage can result in spermatogenic failure-a leading cause of male infertility tha affects roughly 1 in 100 men worldwide...
- Selective Translational Regulation of Male FertilityMary Ann Handel; Fiscal Year: 2013..The male infertility phenotype of Eif4g3 mutant mice provides compelling evidence for the crucial importance of translational ..
- Epigenetic Defects in Human Spermatozoa: Biomarker of Infertility and Sperm ToxicREBECCA Z contact SOKOL; Fiscal Year: 2010..For most male infertility cases, the etiology is unknown and specific therapy is not available...
- Conferene on the basic cell and molecular biology of cilia and flagella as relateJoel Rosenbaum; Fiscal Year: 2007..together a meeting in which leaders in research on diseases such as PKD, Situs Inversus, Hydrocephalus and male infertility can meet with others researching the biochemistry, structure, and assembly of cilia and flagella...
- Cisplatin and Mechanisms of Long-term Male InfertilityJOHN RICHBURG; Fiscal Year: 2007..unreadable] [unreadable]..
- Aromatase Inhibitor in Males with Adrenal HyperplasiaKyriakie Sarafoglou; Fiscal Year: 2006..CAH patients still manifest the adverse effects (compromised final height, polycystic ovarian disease, male infertility, etc.) of elevated androgens/estrogens...
- New Mouse Mutation Exhibiting Failed FertilizationMary Ann Handel; Fiscal Year: 2006..Understanding causes of male infertility will likely aid in identification of suitable contraceptive targets...
- INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELESusan Benoff; Fiscal Year: 2004DESCRIPTION: Varicocele-associated human male infertility (VAI) represents greater then 20 percent of male infertility in the US. Surgical repair of varicocele restores fertility only 1/3 of time...
- BIOCHEMICAL MARKERS OF SPERM FERTILITYGabor Huszar; Fiscal Year: 1999he central theme of our research is idiopathic or unexplained male infertility which affects about 1.5 million American men. For the present proposal we have identified a fertIle control population...
- PORTABILITY OF BIOCHEMICAL MARKERS OF SPERM MATURITYGabor Huszar; Fiscal Year: 2001..translation and the single sperm DNA comet assay, which highlight sperm DNA fragmentation, a known cause of male infertility and increased rates of pregnancy loss...
- MALE INFERTILITY: SPERM MOTILITY AND AXONEMAL STABILITYREGINA TURNER; Fiscal Year: 2001..In animals, male infertility can be economically devastating when it occurs in a genetically valuable individual...
- CENTROSOME DEFECTS AS CAUSES OF MALE INFERTILITYGerald Schatten; Fiscal Year: 1999..investigates the microtubule organizing capacity of the human sperm centrosome as causes of idiopathic male infertility . Eighteen questions are posed in four specific aims using sperm from fertile and infertile men...
- CELL-CELL INTERACTIONS IN TESTIS DEVELOPMENTMichael Skinner; Fiscal Year: 2007..Abnormal testis development and male infertility may in part be due to inappropriate control of testicular cell growth and differentiation during development...
- ALTERNATIVE MRNA PROCESSING DURING SPERMATOGENESISPETER CHALLONER; Fiscal Year: 1992..in the trans- acting factors involved in alternative pre-MRNA processing in spermatids may be one source of male infertility. In addition, these defects could produce anomalous transcripts from cellular proto-oncogenes, causing the ..
- HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTSSusan Benoff; Fiscal Year: 2005..by current somatic cell apoptosis mechanisms, this prompted our hypothesis that lead exposures produce male infertility by altering calcium homeostatsis, and a related detailed mechanism of lead action...
- ANALYSIS OF THE ROLE OF GCNF IN SPERMATOGENESISAustin Cooney; Fiscal Year: 1999Male idiopathic sterility is the form of male infertility about which least is known because it is due to multiple causes. Generally, affected males display gross or subtle abnormalities in sperm function...
- Role of Cyclic Nucleotides in Sperm FunctionMarco Conti; Fiscal Year: 2009..Ablation of sAC in mice produces complete male infertility and major disruption in sperm motility...
- Role of Y chromosomal genes in male fertilityAlexander I Agoulnik; Fiscal Year: 2010..The most frequent cause of etiopathogenetic male infertility revealed by molecular genetic techniques is a deletion of the Y chromosome...
- PURIFIED TESTIS ANTIGENS AND TESTICULAR AUTOIMMUNITYKenneth Tung; Fiscal Year: 1991..to clarify the pathogenesis of murine EAO as model of organ-specific auto-immune disease, as a cause of male infertility, and as a mew approach to study Sertoli cell biology...